Hub : Genes

Preb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Preb 0.07 0.04 1.2e-07 0.07 0.06 0.07 0.06 9.4e-07 1.1e-06 9.0e-07 1.8e-06
2 Liver intron excision ratio chr6_25420313_25420487 0.03 0.03 2.6e-03 0.02 0.02 0.02 0.02 2.1e-03 2.0e-03 3.2e-03 2.3e-03
3 Liver intron excision ratio chr6_25420567_25420675 0.03 0.03 1.9e-03 0.02 0.02 0.02 0.02 1.3e-03 1.4e-03 1.9e-03 1.6e-03
4 Liver mRNA stability Preb 0.08 0.07 5.7e-08 0.07 0.07 0.07 0.07 2.3e-08 3.3e-08 2.6e-08 3.1e-08
5 BLA gene expression Preb 0.14 0.09 6.5e-08 0.13 0.12 0.13 0.13 1.7e-07 3.7e-07 2.6e-07 3.1e-07
6 PL gene expression Preb 0.08 0.05 8.7e-11 0.09 0.1 0.09 0.09 1.0e-09 7.5e-11 3.5e-10 3.8e-10
7 PL intron excision ratio chr6_25421678_25421932 0.04 0.04 5.4e-04 0.04 0.03 0.03 0.04 6.3e-05 2.3e-04 1.3e-04 4.6e-05
8 BLA intron excision ratio chr6_25421678_25421932 0.09 0.07 1.1e-04 0.08 0.06 0.07 0.07 6.6e-05 3.3e-04 1.9e-04 1.5e-04
9 PL mRNA stability Preb 0.08 0.07 2.1e-06 0.06 0.03 0.03 0.05 3.2e-07 3.2e-04 2.3e-04 2.3e-06
10 NAcc gene expression Preb 0.04 0.04 7.6e-05 0.03 0.03 0.02 0.03 3.7e-04 9.9e-05 2.6e-03 2.4e-04
11 Brain mRNA stability Preb 0.04 0.04 2.9e-03 0.02 0.01 0.02 0.01 4.8e-03 2.2e-02 9.0e-03 1.7e-02
12 BLA mRNA stability Preb 0.05 0.05 5.5e-03 0.03 0.03 0.01 0.03 6.1e-03 7.1e-03 5.6e-02 9.3e-03
13 OFC gene expression Preb 0.24 0.2 4.5e-04 0.08 0.06 0.06 0.06 6.5e-03 1.3e-02 1.7e-02 1.3e-02
14 NAcc intron excision ratio chr6_25421358_25421519 0.02 0.02 8.8e-03 0 0 0 0 7.2e-02 8.9e-02 1.9e-01 1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density4.98.110.4-2.92.93.03.0-3.02.9-3.23.23.22.92.02.4-2.0-2.6
Area under the delay curve0.10.10.20.1-0.1-0.1-0.1-0.1-0.10.3-0.3-0.3-0.1-0.3-0.50.40.2
BMI with tail0.82.67.71.5-1.3-0.9-0.91.2-1.01.6-1.6-1.6-0.9-2.8-2.22.61.1
BMI without tail0.20.51.10.8-0.5-0.5-0.50.4-0.50.8-0.8-0.8-0.5-0.9-0.91.10.4
Body weight1.98.011.53.1-2.9-2.7-2.72.5-2.72.6-2.6-2.6-2.6-3.4-3.33.22.6
Weight adjusted by age0.10.10.2-0.20.1-0.1-0.1-0.20.10.1-0.2-0.20.20.20.5-0.5-0.3
Bone surface2.54.46.3-2.12.12.32.3-2.32.2-2.52.52.52.20.61.6-1.4-1.7
Bone volume2.74.66.9-2.22.22.32.3-2.32.2-2.62.62.62.11.31.6-1.2-1.8
Breakpoint value in progressive ratio session1.21.32.2-0.91.11.01.0-1.41.1-1.51.51.51.10.50.9-0.9-1.1
Number of licking bursts0.10.11.50.0-0.10.20.2-0.20.2-0.00.10.10.1-1.2-0.20.40.3
Context. condit. distance diff. score0.00.00.30.0-0.0-0.1-0.10.1-0.1-0.10.10.1-0.20.6-0.0-0.30.2
Locomotion velocity, session 10.20.21.90.1-0.20.00.00.10.00.4-0.4-0.40.0-1.4-0.80.50.2
Locomotion distance, session 11.51.92.8-1.51.41.71.7-1.51.6-1.31.31.31.50.11.2-1.3-1.1
Locomotion velocity, session 20.20.20.50.5-0.5-0.5-0.50.5-0.50.5-0.5-0.5-0.6-0.3-0.40.30.7
Locomotion distance, session 20.00.00.2-0.10.00.10.1-0.10.10.0-0.0-0.00.1-0.50.1-0.2-0.0
Locomotion velocity, session 30.81.02.1-1.00.90.90.9-0.70.9-0.80.80.81.00.81.3-1.5-1.3
Locomotion distance, session 30.80.91.3-1.00.91.11.1-0.91.1-0.80.80.81.10.10.9-1.0-1.0
Stereotopy head waving bouts, day 32.02.34.4-1.51.61.51.5-1.51.5-1.31.21.21.52.11.4-1.5-1.8
Stereotopy head waving duration, day 30.20.21.2-0.40.50.30.3-0.50.4-0.20.20.20.41.10.4-0.5-0.7
Locomotion velocity, session 71.11.21.8-1.11.11.21.2-1.11.2-1.31.31.31.20.50.7-0.5-1.1
Locomotion distance, session 70.10.21.0-0.20.20.40.4-0.40.4-0.50.50.50.4-1.0-0.10.3-0.1
Stereotopy head waving bouts, day 70.10.10.30.1-0.1-0.1-0.10.2-0.20.6-0.6-0.6-0.20.6-0.1-0.00.1
Stereotopy head waving duration, day 70.40.51.7-0.70.70.60.6-0.70.6-0.40.40.40.61.30.7-1.1-0.8
Locomotion velocity, session 80.40.40.7-0.60.60.50.5-0.80.5-0.70.70.70.50.80.6-0.9-0.4
Locomotion distance, session 80.30.50.7-0.70.70.80.8-0.80.7-0.70.70.70.60.80.5-0.8-0.3
Degree of sensitization distance0.80.91.51.0-0.9-0.9-0.90.7-0.90.7-0.7-0.7-0.9-1.1-1.01.21.1
Degree of sensitization stereotypy0.30.30.60.4-0.5-0.5-0.50.5-0.50.8-0.8-0.8-0.5-0.0-0.40.20.5
Conditioned locomotion3.44.05.9-2.02.01.91.9-2.01.9-1.91.91.91.82.32.1-2.4-2.1
Cocaine response after cond. corrected0.50.50.9-0.80.91.01.0-0.90.9-0.70.70.70.90.3-0.10.2-0.4
Cocaine response after cond. not corrected1.21.42.1-1.31.31.41.4-1.31.3-1.21.21.21.30.90.5-0.5-0.9
Cocaine response before conditioning1.72.04.4-1.41.31.21.2-1.11.2-1.21.11.11.21.92.0-2.1-1.4
Saline control response0.91.12.0-1.11.01.01.0-1.11.0-1.01.11.10.91.01.1-1.4-0.9
Bone: connectivity density4.67.29.2-2.72.72.92.9-2.82.8-3.03.03.02.81.22.4-2.2-2.5
Bone: cortical apparent density0.30.51.3-0.70.60.60.6-0.60.6-0.70.70.70.60.11.1-0.9-0.5
Bone: cortical area0.30.51.1-0.60.50.70.7-0.70.7-1.01.11.10.7-0.50.2-0.1-0.2
Bone: cortical porosity2.12.34.8-1.41.41.21.2-1.41.3-1.61.61.61.22.21.5-1.8-1.5
Bone: cortical porosity1.71.83.7-1.31.31.21.2-1.21.2-1.51.51.51.11.91.1-1.4-1.3
Bone: cortical thickness0.10.10.50.2-0.3-0.1-0.10.2-0.2-0.10.10.1-0.3-0.6-0.50.50.7
Bone: cortical thickness1.41.62.0-1.31.31.41.4-1.31.4-1.41.41.41.30.71.2-1.1-0.9
Bone: cortical tissue density0.30.31.0-0.60.50.50.5-0.50.5-0.50.60.60.5-0.11.0-0.8-0.4
Condit. Reinf. active minus inactive responses0.91.02.31.0-1.0-0.9-0.91.0-0.81.0-1.0-1.0-0.8-1.5-1.21.10.9
Condit. Reinf. active-inactive response ratio0.80.91.81.0-1.0-1.0-1.01.0-0.90.9-0.9-0.9-0.8-1.4-0.90.90.7
Condit. Reinf. active responses0.10.10.1-0.30.30.40.4-0.30.4-0.10.10.10.4-0.3-0.30.2-0.2
Condit. Reinf. inactive responses1.21.52.1-1.41.41.51.5-1.41.4-1.01.01.01.31.10.7-0.8-1.1
Incentive salience index mean0.00.10.40.0-0.00.10.10.00.1-0.00.00.00.1-0.6-0.50.50.0
Condit. Reinf. lever presses0.30.40.6-0.70.80.80.8-0.70.7-0.70.70.70.70.70.1-0.0-0.6
Condit. Reinf. active minus inactive responses3.74.66.0-2.32.22.12.1-2.22.2-1.81.81.82.32.02.5-2.4-2.4
Condit. Reinf. active-inactive response ratio0.90.91.8-1.11.01.01.0-0.91.0-0.50.50.51.01.10.9-1.3-1.1
Condit. Reinf. active responses3.14.35.7-2.12.12.02.0-2.12.1-1.91.81.82.22.02.4-2.1-2.3
Condit. Reinf. inactive responses1.72.12.8-1.41.41.41.4-1.51.5-1.61.61.61.51.31.7-1.0-1.5
Condit. Reinf. lever presses2.12.85.0-1.81.61.61.6-1.71.6-1.31.31.31.61.92.0-2.2-1.6
Condit. Reinf. lever reinforcers received2.73.95.6-2.02.01.91.9-2.02.0-1.71.71.72.11.92.4-2.0-2.3
Conditioned reinforcement - actives2.02.03.4-1.11.41.21.2-1.41.2-1.51.51.51.11.81.6-1.6-1.4
Conditioned reinforcement - inactives3.23.65.4-2.32.01.81.8-1.81.9-1.81.81.81.91.71.9-2.0-1.8
Conditioned locomotion0.91.14.1-0.50.80.30.3-1.10.5-0.80.80.80.52.01.5-1.6-1.2
Patch foraging indifference point 0 sec0.30.51.30.8-0.8-0.8-0.80.7-0.70.3-0.3-0.3-0.6-1.1-1.00.80.8
Patch foraging indifference point AUC2.42.84.1-1.51.71.91.9-1.71.9-2.02.02.01.9-0.01.0-0.9-1.5
Delay disc. indifference point, 0s delay4.14.56.12.1-2.0-1.9-1.91.9-2.12.2-2.2-2.2-2.1-1.7-2.52.42.4
Delay disc. indifference point, 16s delay0.10.10.1-0.30.20.30.3-0.30.30.1-0.1-0.10.30.10.2-0.2-0.3
Delay disc. indifference point, 2s delay0.40.40.70.6-0.6-0.5-0.50.5-0.60.8-0.8-0.8-0.6-0.4-0.80.70.8
Delay disc. indifference point, 24s delay0.70.71.3-0.80.90.80.8-1.00.7-0.60.60.60.71.11.0-0.9-0.6
Delay disc. indifference point, 4s delay0.10.10.40.1-0.00.10.1-0.00.00.3-0.3-0.3-0.0-0.6-0.60.60.2
Delay disc. indifference point, 8s delay0.00.00.10.00.00.00.0-0.30.0-0.10.10.1-0.00.1-0.20.10.0
Indifference point function ln k0.10.21.9-0.00.0-0.2-0.2-0.0-0.20.2-0.2-0.2-0.31.40.2-0.40.2
Indifference point function log k0.10.21.9-0.00.0-0.2-0.2-0.0-0.20.2-0.2-0.2-0.31.40.2-0.40.2
Patch foraging total patch changes 0 sec0.30.51.40.7-0.7-0.7-0.70.6-0.60.2-0.1-0.1-0.5-1.2-1.00.90.8
Patch foraging total patch changes 12 sec0.70.91.91.0-1.0-0.9-0.91.1-0.90.5-0.5-0.5-0.9-1.4-1.11.11.0
Patch foraging total patch changes 18 sec0.20.21.60.2-0.10.00.00.00.1-0.40.40.40.1-1.3-0.40.60.3
Patch foraging total patch changes 24 sec0.60.81.40.9-0.9-0.9-0.90.9-0.80.7-0.7-0.7-0.8-1.2-0.80.91.1
Patch foraging total patch changes 6 sec0.10.21.80.3-0.3-0.1-0.10.2-0.0-0.00.00.00.1-1.3-0.70.70.3
Patch foraging time to switch 0 sec0.10.20.60.1-0.2-0.3-0.30.3-0.10.7-0.8-0.8-0.1-0.40.20.00.0
Patch foraging water rate 0 sec0.20.31.2-0.10.20.20.2-0.50.1-0.80.80.80.01.10.2-0.4-0.2
Patch foraging water rate 12 sec1.11.72.91.4-1.5-1.6-1.61.4-1.61.3-1.2-1.2-1.7-0.2-0.30.41.2
Patch foraging water rate 18 sec0.50.71.20.7-0.7-1.0-1.00.9-1.00.8-0.8-0.8-1.11.1-0.1-0.00.7
Patch foraging water rate 24 sec1.52.13.31.8-1.7-1.8-1.81.5-1.81.2-1.2-1.2-1.8-0.6-0.91.01.3
Patch foraging water rate 6 sec1.01.42.51.3-1.3-1.3-1.31.4-1.51.2-1.2-1.2-1.60.0-0.40.51.4
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.00.10.00.0-0.00.1-0.20.20.20.10.10.0-0.0-0.2
Distance traveled before self-admin0.10.10.7-0.10.10.20.2-0.1-0.00.3-0.3-0.3-0.10.80.2-0.20.2
Distance traveled after self-admin1.11.21.91.1-1.0-0.7-0.71.1-1.01.3-1.3-1.3-1.1-0.7-1.31.31.4
Extensor digitorum longus weight4.316.918.3-4.24.24.24.2-4.24.2-4.34.34.34.23.24.0-3.9-4.0
Bone: elastic displacement0.91.11.9-1.01.00.80.8-0.90.8-1.21.21.20.91.41.0-1.1-1.0
Bone: elastic work0.91.21.5-1.11.11.11.1-1.11.1-1.21.21.21.10.80.9-0.9-1.1
Bone: endosteal estimation0.40.91.5-0.90.91.01.0-1.11.0-1.21.21.21.1-0.30.7-0.5-0.7
Bone: endosteal perimeter0.10.30.6-0.40.50.60.6-0.70.6-0.80.80.80.6-0.40.20.0-0.3
Epididymis fat weight13.230.836.66.1-5.9-5.9-5.95.4-5.75.0-5.0-5.0-5.6-5.4-5.75.55.3
Delta time in closed arm before/after self-admin0.20.11.20.3-0.3-0.1-0.10.1-0.10.0-0.0-0.0-0.1-1.1-0.40.50.5
Delta time in open arm before/after self-admin0.30.30.9-0.60.60.50.5-0.50.6-0.50.50.50.70.30.6-0.5-1.0
Diff in mean of infusions in LGA sessions0.30.30.9-0.40.50.50.5-0.70.5-0.90.90.90.5-0.00.2-0.2-0.5
Delay discount exponential model param0.00.00.10.2-0.2-0.2-0.20.4-0.20.0-0.0-0.0-0.20.00.2-0.10.1
Extinction: sum of active levers before priming0.30.30.4-0.60.50.60.6-0.60.6-0.60.60.60.6-0.20.6-0.5-0.6
Active lever presses in extinction session 60.70.71.1-0.60.80.60.6-1.00.7-1.01.01.00.80.80.9-0.9-0.9
Bone: final force0.20.30.8-0.30.40.50.5-0.70.5-0.80.90.90.4-0.50.3-0.2-0.2
Bone: final moment0.20.40.9-0.40.40.50.5-0.70.5-0.90.90.90.5-0.50.3-0.2-0.3
Food consumed during 24 hour testing period0.10.20.4-0.50.40.60.6-0.60.5-0.30.30.30.5-0.0-0.1-0.2-0.2
Glucose0.20.30.40.5-0.5-0.5-0.50.6-0.50.6-0.6-0.6-0.5-0.6-0.50.50.3
Heart weight8.211.715.23.4-3.5-3.4-3.43.9-3.63.7-3.7-3.7-3.6-2.5-2.82.73.7
Delay discount hyperbolic model param0.00.00.20.2-0.2-0.3-0.30.4-0.30.0-0.0-0.0-0.20.10.2-0.20.1
Intermittent access intake day 1-15 change0.30.31.0-0.40.60.80.8-0.50.5-0.20.20.20.31.00.7-0.6-0.2
Intermittent access intake escalation0.10.10.4-0.10.30.50.5-0.30.20.1-0.1-0.10.10.60.4-0.30.1
Intermittent access intake escalation 20.20.20.60.2-0.20.10.10.5-0.20.8-0.8-0.8-0.3-0.4-0.40.50.6
Intermitt. access day 1 inactive lever presses0.30.30.7-0.80.50.30.3-0.40.4-0.80.80.80.50.30.7-0.6-0.4
Intermitt. access day 15 inactive lever presses9.09.911.9-3.43.33.33.3-3.13.4-3.33.33.33.51.92.7-2.7-3.1
Intermitt. access escalation Index0.60.52.50.4-0.4-0.0-0.00.4-0.10.8-0.8-0.8-0.1-1.6-1.01.10.5
Intermittent access day 1 total infusions5.56.38.0-2.82.62.42.4-2.42.5-2.52.52.52.52.52.5-2.5-2.6
Intermittent access day 15 total infusions2.73.03.8-1.91.91.91.9-1.61.8-1.51.51.51.72.01.8-1.8-1.5
Intermittent access terminal intake (last 3 days)2.42.63.7-1.81.71.71.7-1.51.6-1.31.31.31.51.91.8-1.8-1.4
Intermittent access total infusions2.62.94.5-1.81.71.51.5-1.71.5-1.61.61.61.52.11.9-2.0-1.6
Intermittent access day 1 locomotion2.32.43.1-1.81.61.51.5-1.51.5-1.61.61.61.51.31.6-1.6-1.6
Intermittent access day 15 total locomotion0.80.91.2-1.11.00.90.9-1.01.0-0.80.80.81.00.71.1-1.0-0.9
Intermittent access total locomotion0.50.51.0-0.80.70.50.5-0.80.6-0.70.70.70.60.71.0-1.0-0.8
Intermittent access standard deviation0.40.40.7-0.70.50.40.4-0.50.5-0.80.80.80.50.60.8-0.8-0.5
Left kidney weight0.00.10.7-0.1-0.1-0.2-0.20.2-0.3-0.00.00.0-0.30.80.3-0.50.4
Right kidney weight1.02.94.21.6-1.9-1.9-1.91.9-2.01.7-1.7-1.7-2.0-0.9-1.21.02.0
Cocaine induced anxiety0.50.50.8-0.80.70.90.9-0.70.8-0.90.90.90.8-0.10.5-0.4-0.6
Post-drug Anxiety1.11.22.40.9-0.9-0.7-0.71.1-0.81.1-1.1-1.1-0.9-1.5-1.41.41.3
Baseline Anxiety2.12.33.21.5-1.4-1.4-1.41.5-1.41.8-1.8-1.8-1.4-0.8-1.61.51.4
Tail length0.10.20.40.6-0.4-0.5-0.50.2-0.50.1-0.0-0.0-0.60.4-0.1-0.10.3
Length with tail1.14.15.92.4-2.3-2.3-2.32.0-2.41.6-1.6-1.6-2.4-1.3-1.71.42.2
Length without tail0.61.31.81.2-1.3-1.2-1.21.3-1.30.8-0.8-0.8-1.3-1.1-1.20.81.4
Times rat made contact with spout1.92.23.8-1.41.41.51.5-1.61.4-1.92.02.01.41.31.1-0.9-1.1
Lifetime Intake3.74.25.2-2.12.11.81.8-2.11.9-2.02.02.01.92.32.2-2.3-2.0
Liver weight, left1.52.33.61.5-1.5-1.4-1.41.3-1.41.5-1.5-1.5-1.5-1.5-1.91.91.6
Liver weight, right8.914.816.23.9-3.9-3.8-3.83.9-3.84.0-4.0-4.0-3.9-3.6-3.73.84.0
Locomotor activity0.60.93.30.9-0.8-0.8-0.80.6-0.70.7-0.7-0.7-0.7-1.8-1.21.31.0
Locomotor testing distance0.10.10.9-0.10.10.20.2-0.20.3-0.20.20.20.4-1.0-0.00.1-0.2
Locomotor testing rearing0.71.12.0-0.81.00.90.9-1.31.1-1.01.01.01.20.21.1-1.0-1.4
Locomotion in novel chamber0.60.81.61.3-1.0-1.1-1.11.0-1.00.6-0.6-0.6-1.0-0.7-0.80.70.5
Locomotion in novel chamber post-restriction2.42.95.51.8-1.8-2.0-2.01.6-1.61.5-1.5-1.5-1.5-2.4-1.41.61.3
Fecal boli incidents, locomotor time 10.50.51.7-0.70.60.60.6-0.40.5-0.80.80.80.41.30.8-0.9-0.6
Change in fecal boli incidents, locomotor task4.74.46.32.2-2.2-2.2-2.21.9-2.11.8-1.8-1.8-2.1-2.2-2.52.42.2
Time >=10cm from walls, locomotor time 10.10.10.20.3-0.3-0.4-0.40.1-0.40.1-0.1-0.1-0.40.2-0.1-0.00.1
Bouts of movement, locomotor time 12.22.43.1-1.61.51.61.6-1.81.7-1.51.51.51.71.41.6-1.5-1.3
Total resting periods, locomotor time 12.62.83.5-1.71.71.81.8-1.91.8-1.61.61.61.81.61.6-1.6-1.4
Rest time, locomotor task time 10.20.21.3-0.40.30.20.2-0.30.3-0.40.40.40.31.10.3-0.5-0.2
Distance moved, locomotor task time 11.61.72.91.2-1.2-1.1-1.11.2-1.21.7-1.7-1.7-1.3-1.4-1.21.20.9
Vertical activity count, locomotor time 10.90.91.50.8-0.8-0.7-0.70.8-0.81.2-1.2-1.2-0.9-1.0-1.01.00.7
Time >=10cm from walls, locomotor time 20.30.31.0-0.40.50.30.3-0.80.4-0.70.70.70.31.00.5-0.7-0.4
Bouts of movement, locomotor time 20.10.10.60.3-0.4-0.3-0.30.2-0.30.4-0.4-0.4-0.3-0.10.20.20.7
Total resting periods, locomotor time 20.00.00.2-0.0-0.10.10.1-0.10.10.1-0.1-0.10.00.10.4-0.10.5
Rest time, locomotor task time 21.11.21.8-1.31.21.31.3-1.11.3-0.90.90.91.31.20.8-1.0-0.7
Distance moved, locomotor task time 20.81.01.31.1-0.9-1.1-1.10.8-1.11.1-1.1-1.1-1.1-0.9-1.00.90.5
Vertical activity count, locomotor time 20.30.30.60.7-0.6-0.7-0.70.3-0.70.4-0.4-0.4-0.7-0.1-0.60.40.3
Light reinforcement 13.25.88.6-2.72.62.92.9-2.42.8-2.32.32.32.91.21.6-1.6-2.4
Light reinforcement 22.83.75.8-2.42.22.42.4-1.82.3-1.51.51.52.21.41.5-1.5-1.9
Bone: marrow area0.40.91.5-0.90.91.01.0-1.21.1-1.21.21.21.1-0.20.7-0.5-0.8
Bone: maximum diameter0.81.42.3-1.11.11.31.3-1.31.3-1.51.51.51.3-0.30.7-0.5-0.9
Bone: maximum force0.10.10.4-0.10.10.20.2-0.30.2-0.50.60.60.2-0.60.00.1-0.1
Bone: maximum moment0.10.20.4-0.20.20.30.3-0.40.3-0.60.70.70.3-0.50.10.0-0.2
Mean time between licks in bursts2.63.75.11.9-2.0-1.9-1.92.0-1.91.9-1.9-1.9-2.0-1.8-1.91.72.3
Mean num. licks in bursts0.40.52.5-0.60.60.40.4-0.50.4-0.80.80.80.41.60.3-0.5-0.5
Cd content in liver0.10.10.70.0-0.00.10.1-0.10.10.1-0.1-0.10.1-0.8-0.40.20.1
Co content in liver5.15.97.4-2.62.52.62.6-2.52.4-2.32.32.32.32.72.1-2.6-2.2
Cu content in liver0.00.00.1-0.20.20.20.2-0.30.2-0.10.10.10.2-0.20.1-0.2-0.2
Fe content in liver0.00.00.20.00.0-0.1-0.10.00.0-0.10.00.00.1-0.50.4-0.1-0.2
K content in liver0.50.52.90.4-0.4-0.1-0.10.2-0.10.7-0.7-0.7-0.1-1.7-0.91.10.7
Mg content in liver0.70.74.00.6-0.6-0.3-0.30.4-0.30.4-0.4-0.4-0.3-2.0-1.21.40.8
Mn content in liver0.60.61.0-0.80.70.80.8-0.80.9-0.80.80.81.0-0.20.8-0.7-0.8
Na content in liver0.40.40.9-0.70.80.80.8-0.70.7-0.40.40.40.71.00.2-0.1-0.4
Rb content in liver0.10.11.50.2-0.2-0.1-0.10.0-0.00.1-0.1-0.10.1-1.2-0.30.50.1
Se content in liver0.40.42.90.6-0.6-0.6-0.60.3-0.40.5-0.5-0.5-0.4-1.7-0.30.30.6
Sr content in liver0.40.31.10.4-0.4-0.3-0.30.4-0.40.7-0.7-0.7-0.5-0.0-1.00.70.6
Zn content in liver1.31.52.51.3-1.3-1.2-1.20.9-1.21.1-1.1-1.1-1.2-1.6-1.31.21.3
Bone: minimum diameter0.20.32.00.4-0.5-0.3-0.30.1-0.3-0.30.40.4-0.2-1.4-0.70.70.6
Time in familiar zone, hab. session 10.80.72.20.8-0.8-0.8-0.80.7-0.70.6-0.6-0.6-0.7-1.5-1.10.80.9
Time in novel zone, hab. session 10.40.40.80.7-0.7-0.9-0.90.8-0.80.7-0.7-0.7-0.70.10.00.20.2
Total zone transitions, hab. session 10.10.10.2-0.30.30.40.4-0.40.3-0.30.30.30.30.20.4-0.4-0.2
Total locomotion distance, hab. session 10.20.31.6-0.50.50.50.5-0.70.4-0.30.40.40.41.30.4-0.4-0.5
Locomotion velocity, hab. session 10.91.33.1-1.31.21.31.3-1.31.1-0.90.90.91.11.71.0-0.9-1.0
Time in familiar zone, hab. session 20.00.00.3-0.00.10.20.2-0.10.2-0.20.20.20.2-0.5-0.00.00.2
Time in novel zone, hab. session 20.50.50.70.7-0.7-0.9-0.90.8-0.80.8-0.8-0.8-0.8-0.3-0.50.40.4
Total zone transitions, hab. session 20.10.10.3-0.30.20.30.3-0.40.3-0.30.30.30.3-0.50.2-0.4-0.0
Total locomotion distance, hab. session 20.20.30.5-0.50.40.50.5-0.60.5-0.70.70.70.5-0.20.3-0.4-0.2
Locomotion velocity, hab. session 20.40.50.8-0.70.60.80.8-0.80.8-0.90.90.90.70.00.5-0.5-0.4
Novel to familiar place preference ratio1.31.42.21.0-1.1-1.1-1.11.2-1.11.5-1.5-1.5-1.2-0.2-1.11.11.1
Novelty place preference1.91.92.81.3-1.4-1.4-1.41.4-1.41.7-1.7-1.7-1.4-0.5-1.31.21.3
Time in novel zone, NPP test2.12.13.11.4-1.5-1.5-1.51.5-1.51.7-1.8-1.8-1.5-0.5-1.31.21.4
Total zone transitions, NPP test1.31.82.5-1.41.41.51.5-1.41.4-1.11.11.11.40.71.5-1.6-1.3
Total locomotion distance, NPP test1.82.53.1-1.71.71.71.7-1.71.7-1.41.41.41.71.21.6-1.6-1.8
Locomotion velocity, NPP test2.94.14.9-2.12.12.22.2-2.22.2-1.91.91.92.11.52.0-1.9-2.1
Intraocular pressure6.08.410.03.1-3.0-2.9-2.92.9-2.92.6-2.6-2.6-2.9-3.2-2.93.03.1
Delta distance traveled before/after self-admin1.51.62.41.3-1.2-1.1-1.11.3-1.11.3-1.3-1.3-1.1-1.6-1.51.51.3
Delta ambulatory time before/after self-admin0.30.40.80.6-0.5-0.3-0.30.5-0.40.6-0.6-0.6-0.4-0.8-0.90.90.7
Parametrial fat weight5.911.513.53.5-3.5-3.2-3.23.5-3.33.3-3.2-3.2-3.3-3.4-3.73.53.7
Pavlov. Cond. lever latency1.72.13.11.5-1.4-1.6-1.61.5-1.51.8-1.8-1.8-1.5-0.5-1.21.01.3
Pavlov. Cond. magazine entry latency0.00.10.1-0.20.10.20.2-0.20.2-0.30.30.30.2-0.30.3-0.3-0.1
Pavlov. Cond. change in total contacts0.00.00.1-0.20.10.20.2-0.10.2-0.30.30.30.20.00.1-0.1-0.1
Pavlov. Cond. index score0.70.91.3-0.90.91.11.1-0.91.0-1.11.21.21.00.00.7-0.6-0.6
Pavlov. Cond. latency score0.70.91.4-0.90.91.11.1-0.91.0-1.21.21.21.0-0.20.7-0.6-0.6
Pavlov. Cond. lever contacts1.01.11.7-1.11.01.21.2-1.11.1-1.31.31.31.10.50.9-0.8-0.9
Pavlov. Cond. magazine entry number0.50.60.80.8-0.7-0.8-0.80.7-0.80.9-0.9-0.9-0.8-0.0-0.60.60.6
Pavlov. Cond. intertrial magazine entries1.11.32.2-1.21.21.11.1-1.11.1-1.11.11.11.11.51.0-0.9-1.2
Pavlov. Cond. lever-magazine prob. diff.1.51.82.4-1.41.31.51.5-1.41.4-1.51.51.51.40.61.2-1.2-1.1
Pavlov. Cond. response bias1.51.82.1-1.41.31.41.4-1.31.4-1.41.41.41.31.01.3-1.3-1.3
Pavlov. Cond. lever latency1.62.22.81.6-1.5-1.5-1.51.7-1.51.1-1.1-1.1-1.5-1.6-1.41.61.6
Pavlov. Cond. magazine entry latency0.30.40.7-0.70.60.70.7-0.70.7-0.30.20.20.70.20.7-0.8-0.4
Pavlov. Cond. change in total contacts0.60.81.3-1.00.90.90.9-1.10.9-0.80.80.80.90.81.0-1.1-0.8
Pavlov. Cond. index score1.11.42.0-1.31.21.31.3-1.41.2-0.90.90.91.21.11.4-1.4-1.1
Pavlov. Cond. latency score1.21.42.2-1.31.21.31.3-1.41.2-0.90.90.91.21.11.4-1.5-1.1
Pavlov. Cond. lever contacts0.81.01.5-1.11.01.11.1-1.21.0-0.80.80.81.01.11.1-1.2-0.9
Pavlov. Cond. magazine entry number0.10.10.30.5-0.4-0.5-0.50.5-0.50.2-0.2-0.2-0.4-0.1-0.40.50.1
Pavlov. Cond. intertrial magazine entries3.44.45.12.3-2.2-2.3-2.32.2-2.22.0-2.0-2.0-2.1-1.9-1.92.02.0
Pavlov. Cond. lever-magazine prob. diff.0.81.01.5-1.11.01.11.1-1.21.1-0.80.80.81.00.81.2-1.2-0.9
Pavlov. Cond. response bias1.41.92.5-1.61.51.51.5-1.61.5-1.11.01.01.41.31.4-1.4-1.3
Time in closed arm before self-admin0.30.40.80.8-0.7-0.9-0.90.4-0.70.2-0.2-0.2-0.7-0.5-0.40.40.8
Time in closed arm after self-admin1.11.11.91.4-1.2-1.4-1.40.9-1.20.6-0.6-0.6-1.2-1.2-0.80.81.2
Time in open arm before self-admin0.10.10.2-0.1-0.10.20.20.4-0.10.4-0.4-0.4-0.1-0.1-0.20.20.2
Time in open arm after self-admin1.41.52.6-1.61.41.61.6-1.01.5-0.90.90.91.40.61.0-0.9-1.3
Bone: periosteal estimation0.61.22.3-1.01.01.21.2-1.21.2-1.51.51.51.2-0.20.7-0.5-0.7
Bone: periosteal perimeter0.20.30.7-0.50.40.60.6-0.60.6-0.80.80.80.5-0.40.1-0.1-0.2
Bone: post-yield work0.60.81.4-0.80.90.80.8-0.90.8-1.21.21.20.71.10.8-0.9-0.7
Progressive ratio test 1 active lever presses2.22.32.8-1.61.51.11.1-1.51.3-1.61.61.61.41.61.6-1.7-1.6
Progressive ratio test 1 breakpoint1.92.02.5-1.51.41.11.1-1.41.2-1.61.61.61.31.41.5-1.6-1.5
Progressive ratio test 1 inactive lever presses5.66.17.5-2.52.42.12.1-2.42.3-2.62.62.62.32.52.7-2.7-2.6
Progressive ratio test 2 active lever presses0.20.20.9-0.50.40.30.3-0.50.3-0.10.10.10.31.00.6-0.7-0.4
Progressive ratio test 2 breakpoint0.30.31.3-0.60.50.30.3-0.60.3-0.20.20.20.31.10.7-0.8-0.5
Progressive ratio test 2 inactive lever presses2.73.24.0-2.01.81.71.7-1.71.8-1.71.71.71.81.71.9-1.9-1.8
Incentive Sensitization - Responses0.20.20.60.1-0.1-0.1-0.10.2-0.20.8-0.8-0.8-0.30.2-0.20.10.3
Incentive Sensitization - Breakpoint0.30.31.10.2-0.3-0.2-0.20.4-0.41.0-1.0-1.0-0.40.1-0.40.30.5
Sum of active levers in priming session hrs 5-60.50.50.9-0.80.70.90.9-0.60.9-0.50.50.51.0-0.50.2-0.1-0.5
Progressive ratio0.20.20.5-0.30.3-0.0-0.0-0.50.3-0.70.70.70.30.30.5-0.5-0.5
Food seeking constrained by brief footshock5.77.09.5-2.42.52.22.2-2.42.3-2.82.82.82.23.03.1-3.1-2.9
Seeking ratio, punishment vs. effort0.40.50.9-0.70.70.90.9-0.50.7-0.50.50.50.60.90.8-0.8-0.7
Retroperitoneal fat weight20.467.175.08.4-8.7-8.5-8.58.2-8.27.9-7.9-7.9-8.0-8.4-8.08.18.0
Reaction time number correct0.50.71.0-0.80.80.90.9-0.80.9-1.01.01.00.80.80.7-0.7-0.7
Reaction time mean minus median0.00.10.40.00.0-0.1-0.1-0.1-0.1-0.30.30.3-0.00.60.1-0.2-0.2
Reaction time mean minus median AUC0.00.00.10.3-0.2-0.3-0.30.3-0.30.0-0.0-0.0-0.30.2-0.20.20.0
Reaction time num false alarms0.20.22.7-0.1-0.10.20.20.00.20.2-0.2-0.20.3-1.6-0.50.60.1
Reaction time num false alarms AUC0.20.32.6-0.1-0.10.30.3-0.10.30.1-0.1-0.10.4-1.6-0.60.70.2
Reaction time trials correct on left0.50.71.0-0.80.80.90.9-0.80.9-1.01.01.00.80.80.7-0.7-0.7
Reaction time trials on left0.60.81.1-0.90.91.01.0-0.80.9-1.01.01.00.90.80.7-0.7-0.8
Reaction time mean1.01.32.11.2-1.2-1.3-1.31.3-1.41.1-1.1-1.1-1.50.0-0.80.81.3
Reaction time mean AUC0.81.11.81.1-1.1-1.2-1.21.3-1.31.0-1.0-1.0-1.30.1-0.80.81.1
Median of all reaction times1.21.62.41.3-1.3-1.3-1.31.5-1.51.3-1.3-1.3-1.5-0.1-0.90.91.5
Reaction time omissions0.10.10.3-0.20.30.30.3-0.30.3-0.40.40.40.4-0.5-0.50.5-0.2
Reaction time false alarm rate0.40.53.40.3-0.5-0.3-0.30.4-0.20.6-0.6-0.6-0.1-1.8-0.91.00.5
Reaction time premature initiation rate0.30.40.60.5-0.5-0.6-0.60.5-0.50.8-0.8-0.8-0.5-0.4-0.30.40.8
Reaction time premature initiations0.00.00.1-0.0-0.0-0.0-0.00.0-0.00.2-0.2-0.2-0.0-0.00.1-0.00.3
Std. dev. reaction times0.20.30.50.6-0.6-0.7-0.70.5-0.70.3-0.3-0.3-0.70.1-0.30.30.5
Reaction time trials completed0.60.81.1-0.90.91.01.0-0.80.9-1.01.01.00.90.80.7-0.7-0.8
Reaction time trials AUC0.71.01.2-1.01.01.11.1-0.91.0-1.11.11.11.00.90.9-0.9-0.9
Run reversals in cocaine runway, females0.20.20.50.2-0.3-0.4-0.40.5-0.50.4-0.4-0.4-0.60.7-0.0-0.10.4
Run reversals in cocaine runway, males0.30.21.2-0.50.30.20.2-0.20.2-0.40.40.40.21.10.6-0.7-0.6
Latency to leave start box in cocaine runway0.60.61.2-0.70.91.01.0-0.80.8-0.60.60.60.71.10.6-0.7-0.9
Latency to leave start box in cocaine runway, F0.40.50.9-0.80.81.01.0-0.70.8-0.40.40.40.80.50.5-0.5-0.8
Latency to leave start box in cocaine runway, M1.11.12.6-0.71.00.80.8-0.90.9-1.11.11.10.81.61.1-1.2-1.2
Std. dev. time between licks in bursts0.40.41.60.5-0.4-0.2-0.20.2-0.20.5-0.5-0.5-0.3-1.3-0.81.30.8
Total sessions with >9 infusions3.43.85.2-1.81.81.31.3-2.01.6-2.12.12.11.72.22.2-2.3-2.1
Short access day 1 total inactive lever presses4.75.27.9-2.82.52.42.4-2.32.5-2.02.02.02.51.82.3-2.2-2.2
Short access day 10 total inactive lever presses1.01.11.9-1.41.11.11.1-1.01.2-0.90.90.91.30.31.0-0.9-1.2
Short access day 1 total infusions6.06.48.0-2.52.52.22.2-2.62.4-2.82.82.82.52.22.6-2.6-2.7
Short access day 10 total infusions4.34.86.0-2.32.32.02.0-2.22.1-2.22.22.22.12.42.3-2.3-2.1
Short access total infusions3.74.25.0-2.02.01.71.7-2.11.9-2.22.22.21.92.22.2-2.2-2.1
Short access day 1 locomotion8.59.111.3-2.92.92.62.6-3.02.8-3.23.23.22.83.13.4-3.4-3.1
Short access day 10 total locomotion1.01.11.8-1.21.00.90.9-0.91.0-0.90.90.90.91.31.3-1.3-1.0
Short access total locomotion1.01.12.4-1.11.00.70.7-0.90.8-1.01.01.00.81.51.3-1.4-1.0
One hour access (0.3 mA shock)1.82.22.5-1.51.61.61.6-1.61.5-1.51.51.51.51.21.4-1.4-1.3
Compulsive drug intake1.11.14.11.0-0.9-0.7-0.70.9-0.70.6-0.6-0.6-0.7-2.0-1.51.61.0
One hour access (shock baseline)2.42.85.3-1.61.71.41.4-1.81.4-1.41.41.41.42.32.0-2.1-1.6
Social response proportion0.30.31.00.6-0.4-0.5-0.50.3-0.60.1-0.1-0.1-0.60.5-1.00.80.4
Social responses0.10.10.60.3-0.2-0.2-0.2-0.1-0.2-0.10.10.1-0.2-0.2-0.80.60.4
Social time0.10.20.40.5-0.4-0.5-0.50.2-0.50.1-0.1-0.1-0.60.4-0.60.40.4
Soleus weight4.011.715.0-3.43.43.53.5-3.43.4-3.93.93.93.33.02.9-2.9-3.1
Bone: stiffness0.00.10.60.2-0.2-0.0-0.0-0.0-0.1-0.00.00.0-0.1-0.8-0.20.20.1
Tibialis anterior weight3.210.912.7-3.43.43.63.6-3.43.6-3.13.13.13.62.33.2-3.2-3.4
Time to tail flick, vehicle, before self-admin1.91.92.71.6-1.6-1.7-1.71.5-1.61.3-1.3-1.3-1.6-0.9-1.01.01.2
Time to tail flick, vehicle, after self-admin3.63.95.42.2-2.2-2.3-2.31.7-2.11.6-1.6-1.6-2.1-1.8-1.91.91.8
Time to tail flick, test, before self-admin0.60.60.9-0.80.80.70.7-0.70.7-0.70.70.70.70.90.9-0.9-0.8
Time to tail flick, test, after self-admin0.10.10.50.1-0.2-0.4-0.40.2-0.4-0.10.10.1-0.40.70.0-0.20.2
Delta time to tail flick, vehicle, before/after SA0.10.10.30.2-0.2-0.2-0.2-0.1-0.0-0.10.10.10.0-0.5-0.50.50.1
Delta time to tail flick, test, before/after SA0.40.41.2-0.60.60.60.6-0.50.5-0.70.70.70.41.10.5-0.6-0.5
Tibia length2.26.26.62.6-2.5-2.5-2.52.5-2.52.5-2.5-2.5-2.6-2.2-2.42.42.5
Ambulatory time before self-admin0.10.10.6-0.30.30.40.4-0.20.20.2-0.3-0.30.20.80.4-0.5-0.0
Ambulatory time after self-admin0.70.81.40.8-0.7-0.5-0.50.9-0.81.2-1.2-1.2-0.8-0.4-0.90.91.1
Bone: tissue strength0.90.91.30.9-1.0-1.0-1.01.0-1.10.8-0.8-0.8-1.1-0.4-1.10.70.9
Total heroin consumption2.52.93.5-1.71.71.91.9-1.81.8-1.81.81.81.80.91.6-1.5-1.6
Bone: trabecular number3.75.87.8-2.52.52.62.6-2.52.5-2.82.82.82.51.71.9-1.5-2.2
Bone: trabecular spacing3.74.87.62.1-2.1-2.2-2.22.4-2.22.7-2.8-2.8-2.2-1.1-1.91.51.8
Bone: trabecular thickness0.91.11.8-1.01.01.01.0-1.31.0-1.31.31.31.00.80.8-0.4-1.0
Bone: trabecular tissue density0.30.51.5-0.70.60.50.5-0.60.5-0.40.40.40.50.71.2-1.1-0.8
Water consumed over 24 hours1.21.42.2-1.21.21.51.5-1.51.4-1.41.41.41.30.20.4-0.3-0.7
Number of responses in last shaping day1.01.02.3-0.70.90.70.7-1.00.7-1.21.21.20.71.51.0-1.1-0.9