Best TWAS P=2.230785e-07 · Best GWAS P=4.314014e-08 conditioned to 0.6041079
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liver | Nptxr | gene expression | ENSRNOG00000016156 | 0.11 | 0.06 | lasso | 23 | 0.08 | 5.2e-09 | -4.7 | -5.1 | 2.9e-07 | 0.70 | 0.47 | 0.52 | TRUE |
| 2 | PL2 | Apobec3 | alternative TSS | ENSRNOT00000105852 | 0.07 | 0.06 | top1 | 1 | 0.06 | 4.5e-04 | -5.2 | 5.2 | 2.2e-07 | -0.92 | 0.06 | 0.24 | TRUE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.