Hub : Genes

Eif3m

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Eif3m	0.02	0.02	9.0e-03	0.01	0	0.01	0.01	3.3e-02	9.5e-02	9.3e-03	6.9e-02
2	pVTA	gene expression	Eif3m	0.06	0.07	9.0e-03	0.04	0.02	0.01	0.02	8.9e-03	5.8e-02	1.5e-01	6.5e-02
3	Liver	gene expression	Eif3m	0.04	0.04	5.6e-05	0.03	0.03	0.03	0.03	4.9e-04	4.6e-04	4.1e-04	4.5e-04
4	NAcc	gene expression	Eif3m	0.03	0.03	2.4e-03	0.01	0.02	0.02	0.02	1.1e-02	1.7e-03	2.2e-03	2.1e-03
5	BLA	gene expression	Eif3m	0.11	0.1	5.9e-05	0.06	0.1	0.05	0.09	3.7e-04	5.9e-06	7.7e-04	1.1e-05
6	Brain	gene expression	Eif3m	0.03	0.03	1.4e-03	0.02	0.02	0.02	0.02	2.5e-03	3.2e-03	5.4e-03	5.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.5	0.8	1.2	0.0	1.1	0.8	-1.0	-1.0	1.1
Area under the delay curve	0.5	0.5	1.1	-1.0	-0.5	-0.5	0.6	0.6	-0.9
BMI with tail	0.4	1.3	1.9	1.3	1.1	1.0	-1.0	-1.0	1.4
BMI without tail	0.2	0.5	0.6	0.4	0.8	0.7	-0.8	-0.8	0.8
Body weight	1.1	4.4	5.7	2.4	2.0	2.0	-2.0	-2.0	2.1
Weight adjusted by age	0.1	0.1	0.8	0.9	0.0	0.0	0.0	0.0	-0.4
Bone surface	0.3	0.5	0.7	-0.0	0.8	0.6	-0.7	-0.7	0.8
Bone volume	0.7	1.2	1.8	0.4	1.2	1.0	-1.1	-1.1	1.3
Breakpoint value in progressive ratio session	1.2	1.3	1.6	-1.1	-1.1	-1.3	1.1	1.1	-1.0
Number of licking bursts	0.3	0.4	0.5	0.6	0.6	0.6	-0.7	-0.7	0.7
Context. condit. distance diff. score	4.4	5.3	5.6	2.2	2.4	2.3	-2.3	-2.3	2.3
Locomotion velocity, session 1	1.8	1.9	2.7	-1.6	-1.3	-1.3	1.4	1.4	-1.3
Locomotion distance, session 1	0.2	0.2	0.3	-0.5	-0.4	-0.4	0.5	0.5	-0.4
Locomotion velocity, session 2	0.0	0.0	0.1	0.3	-0.0	0.1	0.0	0.0	0.2
Locomotion distance, session 2	0.0	0.0	0.2	-0.5	0.0	-0.1	0.1	0.1	-0.0
Locomotion velocity, session 3	0.1	0.1	0.1	0.1	0.3	0.3	-0.4	-0.4	0.3
Locomotion distance, session 3	0.0	0.1	0.1	0.2	0.2	0.2	-0.3	-0.3	0.1
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	-0.5	-0.3	-0.3	0.3	0.4	-0.5
Stereotopy head waving duration, day 3	0.2	0.3	0.3	0.4	0.6	0.6	-0.5	-0.5	0.5
Locomotion velocity, session 7	0.1	0.1	0.2	0.5	0.2	0.3	-0.3	-0.3	0.3
Locomotion distance, session 7	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.4	0.4	-0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1	-0.1	-0.2
Stereotopy head waving duration, day 7	0.0	0.0	0.1	-0.3	-0.1	-0.2	0.1	0.2	-0.3
Locomotion velocity, session 8	0.2	0.3	0.5	0.4	0.5	0.5	-0.5	-0.5	0.7
Locomotion distance, session 8	2.6	3.8	4.6	1.5	2.1	2.0	-2.0	-2.0	2.0
Degree of sensitization distance	0.3	0.3	0.4	-0.5	-0.5	-0.6	0.6	0.6	-0.6
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.6	-0.4	-0.5	0.4	0.5	-0.6
Conditioned locomotion	5.4	6.3	6.9	-2.2	-2.6	-2.5	2.6	2.6	-2.6
Cocaine response after cond. corrected	3.7	4.2	4.7	-2.0	-2.2	-2.0	2.1	2.1	-1.9
Cocaine response after cond. not corrected	1.0	1.1	1.3	-1.1	-1.1	-1.0	1.1	1.1	-0.9
Cocaine response before conditioning	5.8	7.0	7.7	2.3	2.8	2.7	-2.8	-2.8	2.5
Saline control response	0.1	0.1	0.3	0.6	0.2	0.4	-0.3	-0.3	0.3
Bone: connectivity density	0.6	0.9	1.3	-0.0	1.1	0.9	-1.0	-1.0	1.1
Bone: cortical apparent density	0.0	0.0	0.1	-0.1	0.2	0.0	-0.1	-0.1	0.0
Bone: cortical area	0.6	0.9	2.0	1.4	0.7	0.9	-0.9	-0.9	1.0
Bone: cortical porosity	0.6	0.7	0.9	-0.5	-1.0	-0.9	0.9	0.9	-0.9
Bone: cortical porosity	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.4	0.4	-0.4
Bone: cortical thickness	0.0	0.0	0.1	0.3	0.1	0.1	-0.2	-0.2	0.2
Bone: cortical thickness	1.2	1.4	1.6	-1.2	-1.2	-1.1	1.2	1.2	-1.3
Bone: cortical tissue density	0.0	0.0	0.1	-0.1	0.3	0.1	-0.1	-0.1	0.1
Condit. Reinf. active minus inactive responses	2.3	2.5	2.8	1.3	1.7	1.6	-1.7	-1.7	1.6
Condit. Reinf. active-inactive response ratio	6.5	7.0	7.6	2.2	2.8	2.7	-2.7	-2.7	2.7
Condit. Reinf. active responses	0.3	0.4	0.6	0.3	0.6	0.6	-0.7	-0.7	0.7
Condit. Reinf. inactive responses	2.2	2.7	2.9	-1.6	-1.7	-1.7	1.7	1.7	-1.4
Incentive salience index mean	1.4	1.7	1.9	1.0	1.4	1.4	-1.4	-1.4	1.3
Condit. Reinf. lever presses	0.4	0.5	0.6	0.6	0.8	0.8	-0.8	-0.8	0.7
Condit. Reinf. active minus inactive responses	2.4	2.9	3.5	1.9	1.6	1.7	-1.7	-1.7	1.7
Condit. Reinf. active-inactive response ratio	5.8	6.1	7.0	2.6	2.3	2.5	-2.4	-2.4	2.5
Condit. Reinf. active responses	1.5	2.1	2.5	1.6	1.4	1.5	-1.4	-1.4	1.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0	0.1
Condit. Reinf. lever presses	1.6	2.2	2.6	1.4	1.5	1.4	-1.4	-1.4	1.6
Condit. Reinf. lever reinforcers received	1.6	2.3	2.4	1.6	1.5	1.5	-1.5	-1.5	1.5
Conditioned reinforcement - actives	7.6	7.6	9.1	3.0	2.9	2.9	-2.9	-2.8	2.0
Conditioned reinforcement - inactives	15.3	17.2	20.0	4.2	4.5	4.2	-4.2	-4.2	3.5
Conditioned locomotion	5.3	6.4	7.2	2.7	2.7	2.5	-2.5	-2.5	2.4
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.3	-0.1	0.0	-0.0	-0.0	0.3
Patch foraging indifference point AUC	1.4	1.6	3.3	-1.8	-0.9	-1.2	1.2	1.2	-1.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.1	0.2	0.2	-0.2	-0.2	0.4
Delay disc. indifference point, 16s delay	1.0	1.0	2.2	-1.5	-0.8	-0.8	0.8	0.8	-1.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.0	0.5	0.4	-0.4	-0.4	0.5
Delay disc. indifference point, 24s delay	0.8	0.8	1.7	-1.0	-0.7	-0.7	0.7	0.7	-1.3
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	-0.8	-0.5	-0.6	0.6	0.6	-0.8
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	-0.3	0.0	-0.0	0.1	0.1	-0.4
Indifference point function ln k	0.7	1.0	2.6	1.6	0.5	0.9	-0.9	-0.9	0.7
Indifference point function log k	0.7	1.0	2.6	1.6	0.5	0.9	-0.9	-0.9	0.7
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.2	-0.1	0.0	-0.0	-0.0	0.3
Patch foraging total patch changes 12 sec	0.5	0.7	1.6	0.4	0.9	0.7	-0.7	-0.7	1.2
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.5	0.0	-0.1	0.1	0.1	0.3
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	-0.3	0.0	-0.2	0.1	0.1	0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.1	0.1	0.4
Patch foraging time to switch 0 sec	0.5	0.8	1.0	1.0	0.8	0.9	-0.9	-0.9	1.0
Patch foraging water rate 0 sec	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.1	0.1	-0.0
Patch foraging water rate 12 sec	0.1	0.1	0.2	-0.2	-0.4	-0.2	0.2	0.2	-0.4
Patch foraging water rate 18 sec	0.4	0.5	0.7	0.8	0.8	0.7	-0.7	-0.7	0.6
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.2	0.1	0.2	-0.2	-0.2	0.3
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.1	0.4	0.4	-0.5	-0.4	0.1
Distance traveled before self-admin	0.4	0.4	1.5	1.2	0.5	0.5	-0.5	-0.5	0.4
Distance traveled after self-admin	1.2	1.3	2.7	1.7	1.0	1.0	-1.0	-1.0	1.1
Extensor digitorum longus weight	0.1	0.5	0.9	-0.4	-0.9	-0.8	0.8	0.8	-0.4
Bone: elastic displacement	0.7	0.8	1.1	-1.1	-0.7	-1.0	0.9	0.9	-0.9
Bone: elastic work	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0	0.0	0.0
Bone: endosteal estimation	0.0	0.1	0.1	0.3	-0.4	-0.3	0.3	0.3	-0.2
Bone: endosteal perimeter	0.3	0.7	1.8	1.4	0.5	0.7	-0.7	-0.7	0.7
Epididymis fat weight	1.5	3.6	3.9	1.8	2.0	1.9	-1.9	-1.9	1.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	-0.0	0.1
Delta time in open arm before/after self-admin	1.6	1.5	1.8	-1.3	-1.2	-1.2	1.2	1.2	-1.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.1	0.2	0.0	-0.1	-0.1	0.3
Delay discount exponential model param	0.6	0.6	1.3	1.1	0.6	0.6	-0.6	-0.6	1.0
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.1	0.0
Active lever presses in extinction session 6	0.6	0.6	0.8	0.9	0.8	0.8	-0.8	-0.8	0.6
Bone: final force	0.2	0.3	0.5	0.6	0.3	0.4	-0.4	-0.5	0.7
Bone: final moment	0.1	0.1	0.2	0.3	0.1	0.2	-0.2	-0.2	0.5
Food consumed during 24 hour testing period	3.8	4.5	4.9	2.1	2.0	2.2	-2.1	-2.1	2.2
Glucose	1.0	1.5	1.7	1.2	1.2	1.2	-1.3	-1.3	1.3
Heart weight	0.4	0.6	1.2	-1.1	-0.6	-0.8	0.7	0.7	-0.6
Delay discount hyperbolic model param	0.4	0.4	0.9	1.0	0.4	0.5	-0.5	-0.5	0.8
Intermittent access intake day 1-15 change	1.1	1.1	1.7	0.9	1.0	1.0	-1.0	-1.0	1.3
Intermittent access intake escalation	1.3	1.2	2.3	1.0	1.0	1.1	-1.0	-1.0	1.5
Intermittent access intake escalation 2	1.5	1.5	3.3	1.0	1.0	1.1	-1.1	-1.1	1.8
Intermitt. access day 1 inactive lever presses	3.5	3.8	4.6	2.2	2.1	1.9	-1.9	-1.9	1.7
Intermitt. access day 15 inactive lever presses	4.6	5.1	6.5	2.3	2.5	2.3	-2.4	-2.3	1.5
Intermitt. access escalation Index	0.3	0.3	0.4	-0.5	-0.7	-0.5	0.6	0.6	-0.2
Intermittent access day 1 total infusions	2.9	3.4	4.2	2.0	2.0	1.9	-1.9	-1.9	1.1
Intermittent access day 15 total infusions	5.1	5.7	6.2	2.4	2.5	2.4	-2.4	-2.4	2.2
Intermittent access terminal intake (last 3 days)	5.2	5.7	7.5	2.7	2.4	2.3	-2.3	-2.3	2.2
Intermittent access total infusions	4.9	5.5	6.2	2.3	2.5	2.4	-2.4	-2.4	2.0
Intermittent access day 1 locomotion	2.5	2.6	3.4	1.8	1.7	1.7	-1.6	-1.6	0.8
Intermittent access day 15 total locomotion	1.2	1.3	2.2	1.5	1.2	1.1	-1.1	-1.1	0.8
Intermittent access total locomotion	3.2	3.6	4.4	2.1	2.0	2.0	-1.9	-1.9	1.3
Intermittent access standard deviation	2.8	3.0	3.8	1.6	1.7	1.7	-1.7	-1.7	1.9
Left kidney weight	1.0	2.8	3.3	1.6	1.8	1.7	-1.7	-1.7	1.6
Right kidney weight	1.0	2.7	3.4	1.8	1.6	1.7	-1.6	-1.6	1.6
Cocaine induced anxiety	2.7	3.1	3.3	1.8	1.7	1.8	-1.7	-1.8	1.8
Post-drug Anxiety	0.5	0.6	1.0	1.0	0.7	0.8	-0.7	-0.7	0.6
Baseline Anxiety	5.2	5.5	5.9	-2.4	-2.4	-2.4	2.4	2.4	-2.0
Tail length	0.1	0.2	0.3	0.4	0.5	0.5	-0.6	-0.6	0.2
Length with tail	0.4	1.6	2.0	1.4	1.3	1.3	-1.3	-1.3	1.1
Length without tail	1.0	2.2	3.1	1.8	1.4	1.4	-1.3	-1.4	1.6
Times rat made contact with spout	0.3	0.4	0.5	0.6	0.6	0.6	-0.6	-0.6	0.7
Lifetime Intake	4.6	5.2	6.0	2.3	2.4	2.4	-2.3	-2.3	2.0
Liver weight, left	0.7	1.2	1.5	1.2	1.1	1.1	-1.1	-1.1	0.8
Liver weight, right	2.7	4.4	5.5	2.4	2.0	2.1	-2.1	-2.1	2.0
Locomotor activity	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	0.1	0.1
Locomotor testing distance	1.4	2.3	2.4	1.5	1.4	1.6	-1.5	-1.5	1.5
Locomotor testing rearing	0.5	0.8	1.0	0.5	0.9	1.0	-0.9	-0.9	1.0
Locomotion in novel chamber	0.4	0.5	0.7	0.8	0.7	0.7	-0.7	-0.7	0.4
Locomotion in novel chamber post-restriction	1.7	2.0	3.0	-1.7	-1.4	-1.5	1.4	1.4	-1.0
Fecal boli incidents, locomotor time 1	6.8	7.5	8.6	-2.7	-2.9	-2.8	2.8	2.8	-2.4
Change in fecal boli incidents, locomotor task	2.0	1.9	2.1	1.5	1.4	1.4	-1.4	-1.4	1.1
Time >=10cm from walls, locomotor time 1	1.4	1.4	2.7	-1.7	-1.0	-1.1	1.0	1.0	-1.1
Bouts of movement, locomotor time 1	0.2	0.2	0.9	-0.9	-0.2	-0.2	0.2	0.2	-0.2
Total resting periods, locomotor time 1	0.4	0.4	1.3	-1.1	-0.5	-0.4	0.5	0.5	-0.4
Rest time, locomotor task time 1	2.7	2.9	3.4	-1.8	-1.9	-1.7	1.7	1.7	-1.4
Distance moved, locomotor task time 1	2.6	2.8	3.3	1.8	1.8	1.6	-1.7	-1.7	1.5
Vertical activity count, locomotor time 1	0.6	0.7	1.0	1.0	0.9	0.7	-0.8	-0.8	0.6
Time >=10cm from walls, locomotor time 2	2.4	2.6	2.8	1.5	1.6	1.7	-1.7	-1.7	1.4
Bouts of movement, locomotor time 2	1.7	1.8	2.3	1.1	1.5	1.4	-1.4	-1.4	1.2
Total resting periods, locomotor time 2	1.6	1.7	2.2	1.0	1.5	1.4	-1.4	-1.4	1.2
Rest time, locomotor task time 2	3.5	4.0	5.1	-2.3	-2.0	-1.9	2.0	2.0	-1.9
Distance moved, locomotor task time 2	2.9	3.4	4.3	2.1	1.7	1.7	-1.8	-1.8	1.9
Vertical activity count, locomotor time 2	4.0	4.4	6.9	2.6	1.9	1.9	-1.9	-1.9	2.1
Light reinforcement 1	0.1	0.2	0.4	0.6	0.3	0.3	-0.3	-0.3	0.6
Light reinforcement 2	0.6	0.8	1.0	-0.8	-0.9	-1.0	1.0	1.0	-0.8
Bone: marrow area	0.0	0.1	0.2	0.3	-0.4	-0.3	0.3	0.3	-0.2
Bone: maximum diameter	0.3	0.6	1.7	1.3	0.5	0.7	-0.6	-0.6	0.7
Bone: maximum force	0.4	0.7	1.1	1.1	0.6	0.7	-0.8	-0.8	1.0
Bone: maximum moment	0.2	0.3	0.5	0.7	0.4	0.4	-0.5	-0.5	0.7
Mean time between licks in bursts	0.2	0.3	0.5	-0.7	-0.5	-0.5	0.5	0.5	-0.4
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	0.2	-0.2
Cd content in liver	0.2	0.2	0.3	0.4	0.3	0.4	-0.4	-0.4	0.6
Co content in liver	1.8	2.1	2.8	-1.7	-1.3	-1.4	1.3	1.3	-1.5
Cu content in liver	1.1	1.3	1.7	-0.9	-1.3	-1.1	1.2	1.2	-1.1
Fe content in liver	0.2	0.2	0.2	-0.4	-0.5	-0.5	0.5	0.5	-0.3
K content in liver	0.7	0.7	0.9	-0.7	-0.8	-0.8	0.8	0.8	-0.9
Mg content in liver	0.7	0.7	0.9	-0.7	-0.9	-0.8	0.8	0.8	-0.9
Mn content in liver	1.5	1.7	2.0	-1.4	-1.2	-1.3	1.2	1.2	-1.4
Na content in liver	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	-0.5	0.1
Rb content in liver	1.1	1.3	1.6	-1.3	-1.2	-1.2	1.1	1.1	-1.0
Se content in liver	3.6	4.4	5.0	-1.9	-2.1	-2.1	2.1	2.1	-2.2
Sr content in liver	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.1
Zn content in liver	1.5	1.6	1.8	-1.3	-1.3	-1.3	1.3	1.3	-1.3
Bone: minimum diameter	1.4	2.6	4.1	2.0	1.4	1.5	-1.5	-1.5	1.7
Time in familiar zone, hab. session 1	1.2	1.2	1.5	-1.1	-1.1	-1.0	1.1	1.1	-1.2
Time in novel zone, hab. session 1	2.1	2.0	2.2	1.4	1.4	1.3	-1.4	-1.4	1.5
Total zone transitions, hab. session 1	1.8	2.5	3.0	1.3	1.7	1.6	-1.7	-1.7	1.5
Total locomotion distance, hab. session 1	0.4	0.6	0.7	0.7	0.8	0.7	-0.8	-0.8	0.6
Locomotion velocity, hab. session 1	0.3	0.4	0.4	0.5	0.7	0.6	-0.7	-0.7	0.6
Time in familiar zone, hab. session 2	0.2	0.3	0.4	-0.5	-0.5	-0.4	0.5	0.5	-0.6
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.5	0.4	0.4	-0.4	-0.4	0.6
Total zone transitions, hab. session 2	0.4	0.5	0.7	0.5	0.8	0.8	-0.8	-0.8	0.7
Total locomotion distance, hab. session 2	0.4	0.6	0.7	-0.8	-0.8	-0.7	0.7	0.7	-0.8
Locomotion velocity, hab. session 2	0.3	0.4	0.5	-0.7	-0.7	-0.6	0.6	0.6	-0.7
Novel to familiar place preference ratio	3.7	3.8	4.2	2.1	1.8	2.0	-1.9	-1.9	2.0
Novelty place preference	4.0	4.0	4.5	2.1	1.9	2.0	-2.0	-2.0	2.1
Time in novel zone, NPP test	3.2	3.3	3.7	1.8	1.7	1.9	-1.8	-1.8	1.9
Total zone transitions, NPP test	1.8	2.6	3.1	-1.8	-1.5	-1.6	1.6	1.6	-1.7
Total locomotion distance, NPP test	2.4	3.2	3.7	-1.9	-1.7	-1.7	1.7	1.7	-1.9
Locomotion velocity, NPP test	2.0	2.8	3.2	-1.8	-1.6	-1.6	1.6	1.6	-1.8
Intraocular pressure	0.4	0.5	1.7	-1.3	-0.5	-0.6	0.6	0.6	-0.5
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.2	0.1	0.2	-0.1	-0.1	-0.0
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	0.3	0.4	0.5	-0.4	-0.4	0.6
Parametrial fat weight	0.2	0.4	0.6	0.7	0.6	0.7	-0.5	-0.5	0.8
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.3	-0.7	-0.6	0.7	0.6	-0.2
Pavlov. Cond. magazine entry latency	1.0	1.3	1.5	0.9	1.2	1.1	-1.2	-1.2	1.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.2	0.2	-0.3
Pavlov. Cond. index score	0.1	0.1	0.2	0.1	0.5	0.4	-0.4	-0.4	0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	0.2	0.5	0.5	-0.5	-0.5	0.3
Pavlov. Cond. lever contacts	0.1	0.2	0.2	0.3	0.5	0.5	-0.5	-0.5	0.1
Pavlov. Cond. magazine entry number	1.2	1.4	1.7	-0.9	-1.3	-1.2	1.3	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	0.6	0.2	0.3	-0.2	-0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	0.3	0.2	-0.2	-0.2	0.1
Pavlov. Cond. response bias	0.4	0.5	0.7	0.4	0.8	0.7	-0.8	-0.8	0.7
Pavlov. Cond. lever latency	1.9	2.5	3.0	-1.2	-1.7	-1.6	1.6	1.6	-1.7
Pavlov. Cond. magazine entry latency	1.2	1.3	1.5	1.0	1.2	1.1	-1.2	-1.2	1.2
Pavlov. Cond. change in total contacts	0.3	0.5	0.6	0.5	0.8	0.7	-0.7	-0.7	0.7
Pavlov. Cond. index score	1.8	2.4	2.8	1.3	1.7	1.5	-1.6	-1.6	1.6
Pavlov. Cond. latency score	1.7	2.1	2.5	1.2	1.6	1.5	-1.5	-1.5	1.5
Pavlov. Cond. lever contacts	2.6	3.6	4.1	1.5	2.0	1.9	-1.9	-1.9	2.0
Pavlov. Cond. magazine entry number	0.9	1.1	1.4	-1.0	-1.1	-1.0	1.1	1.1	-1.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	0.1	0.2	-0.2	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	2.5	1.2	1.6	1.4	-1.5	-1.5	1.6
Pavlov. Cond. response bias	2.7	3.7	4.4	1.7	2.0	1.9	-1.9	-1.9	2.1
Time in closed arm before self-admin	3.8	4.3	4.9	1.8	2.2	2.2	-2.2	-2.1	1.9
Time in closed arm after self-admin	3.3	3.4	4.1	1.6	1.8	1.9	-1.8	-1.8	2.0
Time in open arm before self-admin	3.4	3.6	4.0	-2.0	-1.9	-2.0	1.9	1.8	-1.9
Time in open arm after self-admin	7.3	8.1	10.7	-2.3	-2.9	-2.8	2.8	2.8	-3.3
Bone: periosteal estimation	0.1	0.2	0.7	0.8	0.1	0.2	-0.2	-0.2	0.4
Bone: periosteal perimeter	0.7	1.1	2.7	1.6	0.7	1.0	-0.9	-0.9	1.0
Bone: post-yield work	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	0.1	0.0
Progressive ratio test 1 active lever presses	2.5	2.7	3.2	1.6	1.8	1.7	-1.7	-1.7	1.1
Progressive ratio test 1 breakpoint	2.3	2.4	2.8	1.6	1.7	1.6	-1.6	-1.6	1.0
Progressive ratio test 1 inactive lever presses	3.4	3.7	4.6	1.9	2.2	2.0	-2.0	-2.0	1.3
Progressive ratio test 2 active lever presses	3.6	3.9	4.4	2.0	2.1	2.0	-2.0	-2.0	1.6
Progressive ratio test 2 breakpoint	4.3	4.9	5.4	2.3	2.3	2.3	-2.3	-2.3	1.7
Progressive ratio test 2 inactive lever presses	7.8	9.0	10.5	3.2	3.2	3.1	-3.0	-3.0	2.4
Incentive Sensitization - Responses	1.6	1.6	2.2	1.5	1.3	1.3	-1.3	-1.3	0.9
Incentive Sensitization - Breakpoint	1.4	1.4	2.1	1.4	1.2	1.2	-1.2	-1.2	0.9
Sum of active levers in priming session hrs 5-6	1.5	1.4	2.6	-0.8	-1.2	-1.1	1.1	1.1	-1.6
Progressive ratio	0.3	0.3	0.4	0.6	0.5	0.6	-0.6	-0.6	-0.1
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.3	0.4	0.5	-0.5	-0.5	0.3
Seeking ratio, punishment vs. effort	0.3	0.3	0.5	-0.6	-0.7	-0.6	0.6	0.6	0.0
Retroperitoneal fat weight	15.9	52.2	53.3	7.3	7.2	7.3	-7.2	-7.2	7.1
Reaction time number correct	0.3	0.4	0.7	-0.4	-0.8	-0.6	0.6	0.6	-0.6
Reaction time mean minus median	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.3	0.3	-0.2
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	0.3	-0.2
Reaction time num false alarms	1.9	2.6	3.0	-1.2	-1.7	-1.7	1.7	1.7	-1.6
Reaction time num false alarms AUC	3.1	4.2	4.7	-1.6	-2.2	-2.1	2.1	2.1	-2.2
Reaction time trials correct on left	0.3	0.4	0.7	-0.4	-0.8	-0.6	0.6	0.6	-0.6
Reaction time trials on left	0.3	0.5	0.8	-0.5	-0.9	-0.7	0.6	0.6	-0.7
Reaction time mean	0.2	0.2	0.6	0.2	0.5	0.4	-0.4	-0.4	0.8
Reaction time mean AUC	0.3	0.4	0.8	0.3	0.7	0.5	-0.5	-0.5	0.9
Median of all reaction times	0.4	0.6	1.3	0.5	0.8	0.7	-0.7	-0.7	1.1
Reaction time omissions	0.3	0.4	0.8	-0.9	-0.4	-0.7	0.6	0.6	-0.4
Reaction time false alarm rate	2.3	3.1	3.5	-1.4	-1.8	-1.8	1.9	1.9	-1.8
Reaction time premature initiation rate	0.0	0.1	0.2	0.4	-0.1	0.1	0.0	-0.0	0.3
Reaction time premature initiations	0.1	0.1	0.4	0.1	-0.6	-0.3	0.4	0.3	-0.2
Std. dev. reaction times	0.0	0.0	0.0	0.0	0.0	-0.2	0.1	0.1	0.1
Reaction time trials completed	0.3	0.5	0.8	-0.5	-0.9	-0.7	0.6	0.6	-0.7
Reaction time trials AUC	0.2	0.2	0.5	-0.3	-0.7	-0.5	0.4	0.4	-0.5
Run reversals in cocaine runway, females	1.5	1.5	2.1	0.5	1.4	1.4	-1.3	-1.3	0.9
Run reversals in cocaine runway, males	0.1	0.1	0.5	-0.7	-0.2	-0.3	0.2	0.2	-0.2
Latency to leave start box in cocaine runway	0.6	0.6	1.4	-0.1	-0.9	-0.7	0.7	0.7	-1.2
Latency to leave start box in cocaine runway, F	0.7	0.8	1.5	-0.1	-1.1	-0.8	0.8	0.8	-1.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.0	0.1	-0.0	-0.0	-0.3
Std. dev. time between licks in bursts	0.6	0.7	1.0	0.6	0.8	0.9	-0.9	-0.9	1.0
Total sessions with >9 infusions	2.4	2.6	3.0	1.7	1.6	1.7	-1.7	-1.6	1.3
Short access day 1 total inactive lever presses	1.2	1.4	1.8	1.4	1.3	1.1	-1.1	-1.1	1.0
Short access day 10 total inactive lever presses	0.6	0.6	1.1	1.0	0.8	0.7	-0.7	-0.7	0.7
Short access day 1 total infusions	5.9	6.3	7.2	2.3	2.7	2.6	-2.5	-2.5	2.4
Short access day 10 total infusions	1.7	1.9	2.3	1.2	1.5	1.4	-1.4	-1.4	1.2
Short access total infusions	2.6	2.9	3.4	1.7	1.8	1.8	-1.7	-1.7	1.5
Short access day 1 locomotion	0.5	0.5	0.7	0.5	0.7	0.8	-0.8	-0.8	0.8
Short access day 10 total locomotion	2.1	2.4	3.8	1.9	1.5	1.6	-1.5	-1.5	0.9
Short access total locomotion	1.4	1.4	2.2	1.5	1.2	1.2	-1.2	-1.2	0.9
One hour access (0.3 mA shock)	3.9	4.5	4.8	2.2	2.2	2.1	-2.1	-2.1	1.9
Compulsive drug intake	2.3	2.3	2.9	-1.7	-1.6	-1.6	1.6	1.6	-1.1
One hour access (shock baseline)	6.3	7.3	7.9	2.6	2.8	2.8	-2.8	-2.8	2.4
Social response proportion	5.0	5.4	8.2	-2.9	-2.2	-2.3	2.2	2.2	-2.2
Social responses	0.8	1.0	2.4	-1.6	-0.8	-0.9	0.9	0.9	-0.7
Social time	7.7	10.1	13.5	-3.7	-3.0	-3.1	3.1	3.1	-3.0
Soleus weight	0.4	1.2	1.9	-1.4	-1.1	-1.0	1.0	1.1	-1.0
Bone: stiffness	0.9	1.4	2.3	1.5	0.9	1.1	-1.1	-1.1	1.4
Tibialis anterior weight	1.6	5.5	5.9	-2.4	-2.4	-2.4	2.4	2.4	-2.0
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.6	0.4	0.6	0.6	-0.6	-0.6	0.8
Time to tail flick, vehicle, after self-admin	3.9	4.1	4.5	2.1	2.0	2.0	-2.0	-2.0	2.0
Time to tail flick, test, before self-admin	0.3	0.3	0.5	0.7	0.6	0.6	-0.6	-0.6	0.4
Time to tail flick, test, after self-admin	1.2	1.2	1.7	1.3	1.1	1.1	-1.1	-1.1	1.0
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.0	1.4	1.3	1.2	-1.3	-1.3	1.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.1	-0.4	-0.3	0.4	0.4	-0.2
Tibia length	0.1	0.2	0.4	-0.4	-0.6	-0.6	0.5	0.5	-0.3
Ambulatory time before self-admin	0.3	0.4	1.0	1.0	0.4	0.4	-0.5	-0.5	0.5
Ambulatory time after self-admin	1.7	1.8	3.1	1.8	1.3	1.3	-1.3	-1.3	1.0
Bone: tissue strength	0.6	0.6	0.7	-0.8	-0.7	-0.9	0.7	0.7	-0.6
Total heroin consumption	0.5	0.5	0.8	-0.5	-0.8	-0.8	0.7	0.7	-0.9
Bone: trabecular number	0.5	0.8	1.2	-0.0	1.1	0.8	-1.0	-0.9	1.0
Bone: trabecular spacing	0.2	0.2	1.0	1.0	0.0	0.3	-0.1	-0.1	0.2
Bone: trabecular thickness	0.2	0.2	0.4	-0.2	0.5	0.3	-0.4	-0.4	0.6
Bone: trabecular tissue density	0.6	0.9	1.1	-0.9	-0.9	-0.9	1.0	1.0	-1.1
Water consumed over 24 hours	0.5	0.6	0.8	0.3	0.8	0.7	-0.8	-0.8	0.9
Number of responses in last shaping day	1.9	2.0	2.7	1.1	1.5	1.6	-1.6	-1.5	1.1