Hub : Genes

Afap1l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Afap1l2 0.03 0.02 4.9e-04 0.03 0.02 0.03 0.02 6.3e-04 1.0e-03 4.5e-04 1.1e-03
2 NAcc mRNA stability Afap1l2 0.16 0.07 0.0e+00 0.15 0.16 0.15 0.16 9.5e-22 8.6e-23 1.3e-22 1.9e-23
3 IC mRNA stability Afap1l2 0.13 0.07 2.8e-05 0.1 0.11 0.11 0.1 5.9e-05 2.9e-05 3.3e-05 3.6e-05
4 Brain mRNA stability Afap1l2 0.57 0.13 0.0e+00 0.45 0.44 0.44 0.45 8.2e-46 6.1e-45 1.6e-45 3.8e-46
5 LHb mRNA stability Afap1l2 0.5 0.19 2.0e-07 0.32 0.26 0.18 0.28 2.4e-08 8.2e-07 5.2e-05 2.8e-07
6 Brain gene expression Afap1l2 0.2 0.09 0.0e+00 0.1 0.2 0.21 0.21 1.5e-09 1.4e-18 1.9e-19 2.3e-19
7 pVTA mRNA stability Afap1l2 0.25 0.11 0.0e+00 0.28 0.28 0.28 0.29 3.3e-22 4.5e-23 1.0e-22 2.8e-23
8 PL mRNA stability Afap1l2 0.2 0.09 0.0e+00 0.18 0.17 0.19 0.19 9.8e-20 3.3e-18 3.5e-20 4.1e-20
9 IC intron excision ratio chr1_265989926_265993160 0.07 0.05 5.2e-03 0.03 0.03 0.01 0.06 2.0e-02 3.0e-02 1.0e-01 2.4e-03
10 OFC mRNA stability Afap1l2 0.65 0.14 1.8e-09 0.35 0.4 0.36 0.38 4.7e-09 2.0e-10 2.3e-09 7.5e-10
11 IL mRNA stability Afap1l2 0.27 0.16 3.8e-04 0.16 0.12 0.11 0.13 1.3e-04 7.8e-04 1.4e-03 6.3e-04
12 NAcc gene expression Afap1l2 0.09 0.05 8.4e-11 0.02 0.07 0.06 0.06 8.8e-04 1.1e-10 2.4e-09 1.7e-09
13 IC isoform ratio XM_063282801.1 0.06 0.04 9.6e-03 0.03 0.03 0.01 -0 1.6e-02 3.1e-02 7.7e-02 6.2e-01
14 Liver mRNA stability Afap1l2 0.02 0.02 9.1e-03 0.01 0.01 0 0.01 1.0e-02 4.9e-02 7.6e-02 3.3e-02
15 Adipose gene expression Afap1l2 0.04 0.03 8.5e-05 0.03 0.02 0.03 0.02 2.7e-04 9.5e-04 4.4e-04 8.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.73.15.9-1.9-2.0-1.9-1.91.92.4-1.71.9-1.4-2.41.6-2.3-0.30.30.3
Area under the delay curve0.40.62.3-0.6-0.8-1.0-0.50.61.1-0.60.4-0.4-0.60.5-1.50.8-0.1-0.6
BMI with tail8.730.239.0-6.2-6.1-6.1-5.86.05.8-6.05.8-5.8-5.15.6-5.14.24.0-4.2
BMI without tail3.217.323.3-4.8-4.6-4.6-4.54.64.0-4.64.1-4.4-3.74.1-3.63.63.4-3.6
Body weight8.436.645.8-6.7-6.7-6.8-6.66.56.7-6.56.5-6.2-6.36.1-6.04.13.8-4.1
Weight adjusted by age3.610.514.7-3.5-3.5-3.4-3.63.62.6-3.73.8-3.8-2.53.8-2.12.72.7-2.7
Bone surface0.71.42.8-1.5-1.4-1.3-1.31.61.7-1.21.1-0.9-1.41.0-1.5-0.00.60.0
Bone volume2.24.46.6-2.4-2.4-2.3-2.32.52.6-2.22.2-1.9-2.42.0-2.40.71.1-0.7
Breakpoint value in progressive ratio session0.10.21.1-0.3-0.5-0.6-0.30.30.8-0.30.30.0-0.50.2-1.1-0.1-0.30.1
Number of licking bursts0.10.31.3-0.0-0.2-0.4-0.10.10.9-0.10.40.1-0.80.1-1.1-0.5-0.80.5
Context. condit. distance diff. score2.12.63.41.81.81.61.8-1.8-1.61.9-1.81.81.6-1.81.2-0.8-1.10.8
Locomotion velocity, session 10.10.10.40.10.20.30.2-0.0-0.60.1-0.20.00.4-0.10.60.30.2-0.3
Locomotion distance, session 10.20.30.9-0.4-0.1-0.1-0.30.2-0.8-0.30.1-0.60.50.20.80.61.0-0.6
Locomotion velocity, session 20.50.62.90.00.50.60.1-0.2-1.30.3-0.5-0.21.0-0.21.70.81.2-0.8
Locomotion distance, session 21.11.54.0-1.5-0.9-0.8-1.11.40.1-1.20.9-1.6-0.11.10.31.62.0-1.6
Locomotion velocity, session 30.20.31.4-0.00.40.20.1-0.1-1.20.2-0.1-0.40.50.11.00.20.9-0.2
Locomotion distance, session 30.40.51.80.10.70.50.4-0.2-1.30.4-0.6-0.11.0-0.31.30.60.9-0.6
Stereotopy head waving bouts, day 30.20.30.6-0.8-0.5-0.3-0.50.80.3-0.50.4-0.4-0.70.4-0.2-0.60.40.6
Stereotopy head waving duration, day 30.20.31.2-0.3-0.2-0.2-0.30.40.4-0.20.3-0.1-0.70.2-0.4-1.1-0.31.1
Locomotion velocity, session 70.30.40.5-0.7-0.5-0.7-0.60.70.6-0.70.5-0.6-0.40.7-0.50.60.7-0.6
Locomotion distance, session 70.10.10.30.00.20.20.30.00.00.1-0.20.10.5-0.10.30.40.5-0.5
Stereotopy head waving bouts, day 70.10.10.3-0.4-0.2-0.1-0.20.3-0.1-0.3-0.1-0.1-0.00.10.10.50.4-0.4
Stereotopy head waving duration, day 70.81.01.6-1.2-1.3-1.1-1.21.20.8-1.20.9-0.9-1.00.9-0.90.70.6-0.6
Locomotion velocity, session 82.73.24.51.81.92.02.0-1.7-1.92.0-2.12.01.8-2.11.5-1.3-1.11.2
Locomotion distance, session 81.72.53.91.51.81.81.6-1.7-2.01.8-1.81.31.9-1.62.0-0.6-0.40.6
Degree of sensitization distance0.40.41.20.60.20.40.7-0.50.70.4-0.41.0-0.0-0.6-0.7-0.8-1.10.7
Degree of sensitization stereotypy0.00.00.1-0.3-0.3-0.2-0.20.20.1-0.30.0-0.1-0.20.1-0.20.40.1-0.3
Conditioned locomotion0.10.10.40.30.30.40.3-0.2-0.40.2-0.20.10.5-0.10.6-0.00.2-0.0
Cocaine response after cond. corrected1.52.25.51.11.51.71.3-1.1-2.21.3-1.91.12.3-1.42.40.40.5-0.3
Cocaine response after cond. not corrected1.82.75.61.41.81.91.6-1.4-2.21.5-2.11.42.2-1.72.4-0.10.10.1
Cocaine response before conditioning0.40.51.90.50.40.30.4-0.50.50.4-0.10.6-0.5-0.4-0.4-1.4-1.21.3
Saline control response0.20.21.40.00.20.40.0-0.1-0.60.0-0.4-0.00.5-0.21.20.20.7-0.3
Bone: connectivity density0.20.41.0-0.6-0.5-0.4-0.40.61.0-0.30.4-0.1-0.70.2-0.9-1.0-0.21.0
Bone: cortical apparent density0.91.55.50.61.21.10.8-0.8-1.90.9-1.10.22.0-0.72.40.71.0-0.8
Bone: cortical area8.814.319.8-4.5-4.2-4.1-4.24.44.1-4.24.0-3.9-4.13.9-3.31.82.8-1.8
Bone: cortical porosity0.20.21.30.40.20.40.2-0.30.10.3-0.20.4-0.1-0.20.1-1.1-0.51.1
Bone: cortical porosity0.40.41.90.0-0.2-0.0-0.20.10.70.00.30.2-0.70.1-0.6-1.4-0.61.4
Bone: cortical thickness4.57.510.9-3.3-2.9-2.9-3.13.32.7-3.02.9-3.1-2.73.0-1.81.42.5-1.4
Bone: cortical thickness1.82.23.3-1.8-1.5-1.5-1.61.81.3-1.71.5-1.8-1.11.7-0.61.21.8-1.2
Bone: cortical tissue density1.11.86.00.91.41.31.1-1.0-2.11.1-1.30.42.1-0.92.40.60.8-0.6
Condit. Reinf. active minus inactive responses0.10.20.40.30.50.50.1-0.4-0.30.50.1-0.20.20.10.6-0.6-0.10.6
Condit. Reinf. active-inactive response ratio0.20.20.50.50.50.40.2-0.7-0.20.50.10.00.0-0.00.4-0.7-0.50.7
Condit. Reinf. active responses0.70.91.9-1.1-0.8-0.8-1.41.00.7-0.81.4-1.4-1.21.3-0.30.10.8-0.1
Condit. Reinf. inactive responses2.02.64.3-2.0-1.7-1.5-2.02.11.4-1.71.8-1.8-1.91.7-1.00.61.4-0.7
Incentive salience index mean0.20.21.10.30.60.60.1-0.4-0.50.50.0-0.20.40.11.1-0.40.20.4
Condit. Reinf. lever presses0.10.10.6-0.00.30.3-0.2-0.0-0.20.20.2-0.40.30.30.80.10.5-0.0
Condit. Reinf. active minus inactive responses2.13.37.1-1.7-1.8-2.0-1.91.72.3-1.82.2-1.6-2.71.9-2.4-0.20.20.2
Condit. Reinf. active-inactive response ratio0.60.92.1-0.7-1.0-1.0-1.00.71.2-0.81.3-0.8-1.51.1-1.4-0.2-0.20.3
Condit. Reinf. active responses3.85.510.0-2.4-2.4-2.7-2.52.33.0-2.42.7-2.2-3.22.3-3.00.20.6-0.2
Condit. Reinf. inactive responses1.21.83.4-1.5-1.4-1.6-1.41.51.8-1.41.4-1.3-1.81.1-1.80.20.5-0.3
Condit. Reinf. lever presses0.71.02.3-0.9-1.1-1.2-0.90.91.3-1.01.1-0.9-1.30.8-1.50.30.0-0.3
Condit. Reinf. lever reinforcers received2.83.97.4-1.9-2.0-2.3-2.11.92.5-2.02.4-1.9-2.72.0-2.50.10.4-0.1
Conditioned reinforcement - actives0.10.51.9-0.5-0.1-0.0-0.30.4-0.7-0.2-0.2-0.50.50.11.01.11.4-1.1
Conditioned reinforcement - inactives0.20.60.9-0.9-0.9-0.9-0.90.70.8-0.80.7-0.9-0.60.8-0.50.80.5-0.9
Conditioned locomotion0.30.51.6-0.40.00.1-0.30.3-1.1-0.2-0.2-0.60.70.21.21.11.3-1.1
Patch foraging indifference point 0 sec2.67.28.8-2.8-3.0-2.8-2.92.82.7-3.02.8-2.7-2.52.7-2.32.61.8-2.6
Patch foraging indifference point AUC0.20.41.0-0.6-0.9-0.8-0.70.80.8-0.80.5-0.2-0.90.4-1.00.10.0-0.2
Delay disc. indifference point, 0s delay0.20.20.7-0.6-0.4-0.5-0.30.50.5-0.40.0-0.4-0.00.2-0.40.80.3-0.8
Delay disc. indifference point, 16s delay0.10.21.3-0.1-0.4-0.5-0.10.20.8-0.20.10.1-0.30.1-1.20.4-0.4-0.3
Delay disc. indifference point, 2s delay0.50.61.20.80.80.50.9-0.9-0.50.8-1.10.81.1-0.90.20.3-0.6-0.3
Delay disc. indifference point, 24s delay0.30.52.6-0.1-0.6-0.7-0.30.21.4-0.30.40.0-1.00.3-1.60.0-0.80.1
Delay disc. indifference point, 4s delay0.20.20.50.50.50.20.7-0.60.10.5-0.60.50.6-0.6-0.30.0-0.6-0.1
Delay disc. indifference point, 8s delay3.35.57.8-2.5-2.7-2.8-2.52.52.3-2.62.3-2.4-2.12.4-2.52.11.4-2.0
Indifference point function ln k0.00.10.30.10.30.30.1-0.3-0.10.30.2-0.30.10.20.5-0.2-0.10.4
Indifference point function log k0.00.10.30.10.30.30.1-0.3-0.10.30.2-0.30.10.20.5-0.2-0.10.4
Patch foraging total patch changes 0 sec2.47.18.9-2.8-3.0-2.9-2.82.82.7-3.02.7-2.6-2.52.6-2.42.51.7-2.6
Patch foraging total patch changes 12 sec1.41.93.2-1.5-1.6-1.6-1.31.61.7-1.61.1-0.9-1.40.9-1.81.10.7-1.2
Patch foraging total patch changes 18 sec2.45.67.9-2.5-2.8-2.7-2.52.62.7-2.72.4-2.0-2.82.2-2.81.31.1-1.4
Patch foraging total patch changes 24 sec1.13.66.0-2.0-2.4-2.3-1.92.12.2-2.21.7-1.4-2.01.5-2.51.30.8-1.4
Patch foraging total patch changes 6 sec5.08.410.9-3.2-3.3-3.3-3.23.23.0-3.33.0-2.8-3.02.8-2.92.11.9-2.2
Patch foraging time to switch 0 sec0.31.22.01.21.31.11.4-1.3-1.21.2-1.31.11.4-1.30.9-0.2-0.50.3
Patch foraging water rate 0 sec0.41.72.4-1.5-1.4-1.3-1.51.51.4-1.51.4-1.3-1.41.4-1.10.70.8-0.7
Patch foraging water rate 12 sec0.83.15.1-1.9-2.0-1.9-1.92.02.3-1.91.9-1.5-2.21.8-2.10.30.7-0.4
Patch foraging water rate 18 sec0.51.01.6-1.2-1.1-0.9-1.11.10.4-1.21.0-1.3-0.61.2-0.11.01.3-0.9
Patch foraging water rate 24 sec1.01.42.2-1.4-1.2-1.1-1.21.30.8-1.41.2-1.4-0.71.3-0.51.21.5-1.3
Patch foraging water rate 6 sec0.71.02.2-1.4-1.1-0.9-0.91.40.5-1.30.8-1.0-0.50.9-0.40.91.5-1.0
Seeking ratio, delayed vs. immediate footshock0.81.12.81.11.31.41.0-1.1-1.41.2-1.10.61.2-0.71.7-0.3-0.20.4
Distance traveled before self-admin0.71.64.10.81.41.21.1-1.0-1.81.1-1.50.62.0-1.22.00.40.6-0.3
Distance traveled after self-admin0.61.03.40.40.90.90.7-0.5-1.50.6-0.90.21.6-0.61.80.81.0-0.8
Extensor digitorum longus weight0.41.53.5-1.2-1.2-1.3-1.01.31.9-1.21.4-1.0-1.51.1-1.8-0.20.30.1
Bone: elastic displacement0.20.20.80.90.30.20.5-0.7-0.30.4-0.40.50.1-0.40.0-0.2-0.70.2
Bone: elastic work0.50.61.9-0.8-0.6-0.7-0.80.9-0.1-0.80.6-1.0-0.30.90.21.01.4-1.0
Bone: endosteal estimation1.22.93.8-1.9-1.9-1.9-1.81.91.8-1.91.8-1.5-1.91.7-1.91.21.0-1.1
Bone: endosteal perimeter4.410.813.7-3.7-3.7-3.7-3.63.63.1-3.63.4-3.4-3.13.3-2.92.72.6-2.7
Epididymis fat weight7.337.057.2-6.6-6.7-6.7-6.66.57.6-6.46.6-5.9-6.96.0-6.73.43.1-3.4
Delta time in closed arm before/after self-admin0.30.31.00.10.50.50.3-0.1-0.50.4-0.60.10.6-0.41.00.60.6-0.6
Delta time in open arm before/after self-admin1.01.22.3-0.8-1.2-1.2-1.00.91.3-1.21.5-0.7-1.41.2-1.5-0.2-0.20.2
Diff in mean of infusions in LGA sessions0.71.32.51.31.00.91.3-1.3-0.81.3-1.11.50.8-1.10.0-1.2-1.61.0
Delay discount exponential model param0.40.52.20.50.81.00.5-0.5-1.10.6-0.40.40.6-0.51.5-0.80.10.6
Extinction: sum of active levers before priming0.40.51.60.80.60.40.9-0.8-0.00.8-0.71.00.4-0.9-0.4-0.6-1.30.6
Active lever presses in extinction session 60.10.10.3-0.0-0.0-0.3-0.1-0.0-0.10.1-0.20.1-0.2-0.1-0.4-0.5-0.20.5
Bone: final force3.55.78.8-2.9-2.6-2.4-2.73.02.1-2.72.3-2.5-2.12.5-1.41.82.6-1.8
Bone: final moment3.45.48.1-2.8-2.5-2.4-2.62.82.1-2.62.3-2.4-2.12.4-1.51.72.4-1.7
Food consumed during 24 hour testing period0.40.81.40.91.10.91.0-0.9-0.51.2-0.80.80.5-1.00.7-1.1-0.81.2
Glucose1.82.94.1-2.0-2.0-1.9-2.02.01.6-1.91.8-1.8-1.91.9-1.30.91.3-0.9
Heart weight2.54.05.5-2.3-2.3-2.2-2.32.32.4-2.22.3-2.0-2.12.2-2.00.81.0-0.8
Delay discount hyperbolic model param0.30.31.60.40.60.80.3-0.3-0.90.4-0.30.30.3-0.31.2-0.70.10.6
Intermittent access intake day 1-15 change0.31.63.4-1.4-1.2-1.5-1.31.20.7-1.31.0-1.7-0.51.2-0.51.91.1-1.8
Intermittent access intake escalation0.21.32.3-1.2-1.1-1.4-1.21.00.8-1.11.0-1.5-0.71.1-0.71.40.7-1.4
Intermittent access intake escalation 20.50.92.1-1.0-0.8-0.9-0.90.80.2-0.90.7-1.3-0.10.9-0.01.51.1-1.4
Intermitt. access day 1 inactive lever presses0.22.25.2-1.4-1.7-1.7-1.51.42.3-1.51.7-1.2-1.91.4-2.20.2-0.2-0.2
Intermitt. access day 15 inactive lever presses0.00.20.7-0.2-0.5-0.6-0.50.20.9-0.50.6-0.5-0.40.6-0.60.1-0.2-0.2
Intermitt. access escalation Index0.10.30.50.50.60.50.6-0.5-0.60.6-0.70.50.4-0.70.4-0.4-0.30.6
Intermittent access day 1 total infusions0.20.51.3-0.8-0.6-0.5-0.60.80.2-0.70.4-0.6-0.10.6-0.00.91.1-1.0
Intermittent access day 15 total infusions0.20.51.7-0.8-0.6-0.8-0.70.70.2-0.70.2-0.8-0.00.5-0.21.30.8-1.3
Intermittent access terminal intake (last 3 days)0.10.20.9-0.5-0.4-0.5-0.30.4-0.0-0.4-0.0-0.40.20.1-0.00.90.7-0.9
Intermittent access total infusions1.21.52.6-1.5-1.2-1.2-1.31.30.6-1.30.9-1.4-0.51.2-0.31.51.6-1.4
Intermittent access day 1 locomotion0.30.52.0-0.6-0.4-0.4-0.50.6-0.2-0.6-0.1-0.40.50.30.31.41.3-1.4
Intermittent access day 15 total locomotion0.83.15.4-2.0-2.1-2.3-2.01.81.7-2.11.6-1.8-1.61.7-1.91.31.0-1.3
Intermittent access total locomotion1.31.53.6-1.4-1.1-1.2-1.31.20.2-1.30.7-1.3-0.11.10.11.91.8-1.8
Intermittent access standard deviation0.21.22.6-1.1-1.2-1.3-1.01.01.2-1.10.9-1.0-0.60.9-1.11.50.5-1.6
Left kidney weight0.64.58.5-2.4-2.1-2.0-2.02.21.3-2.21.8-2.2-1.12.2-0.92.92.4-2.9
Right kidney weight1.611.217.2-3.7-3.3-3.3-3.53.52.1-3.63.0-3.9-2.03.5-1.34.13.9-4.0
Cocaine induced anxiety2.77.39.43.02.93.03.0-3.0-2.82.9-3.12.82.9-2.82.6-1.4-1.71.4
Post-drug Anxiety1.31.52.51.41.21.11.4-1.3-0.71.3-1.11.40.7-1.30.4-1.6-1.41.4
Baseline Anxiety2.44.06.9-2.0-2.1-2.3-2.02.12.5-2.02.4-1.9-2.62.0-2.6-0.10.60.0
Tail length0.10.30.6-0.5-0.6-0.7-0.60.40.6-0.50.6-0.4-0.80.4-0.70.20.0-0.2
Length with tail0.94.06.2-2.0-2.2-2.2-2.31.92.4-2.02.3-2.0-2.52.1-2.11.00.8-0.9
Length without tail1.910.016.4-3.2-3.3-3.5-3.43.24.0-3.13.8-3.2-4.03.4-3.41.11.3-1.1
Times rat made contact with spout0.10.10.2-0.2-0.1-0.2-0.20.1-0.0-0.10.1-0.40.10.20.20.40.5-0.4
Lifetime Intake1.31.73.0-1.6-1.3-1.2-1.41.40.6-1.41.0-1.5-0.51.3-0.21.51.7-1.5
Liver weight, left3.25.47.5-2.7-2.6-2.7-2.42.62.7-2.62.1-2.1-2.22.0-2.51.81.6-1.9
Liver weight, right4.17.110.1-3.1-2.7-2.6-2.82.91.8-2.82.4-3.0-1.52.8-1.23.23.0-3.2
Locomotor activity1.11.72.6-1.5-1.3-1.3-1.51.40.8-1.41.2-1.6-0.91.3-0.41.41.6-1.4
Locomotor testing distance0.92.25.7-1.8-1.2-1.2-1.51.60.3-1.51.0-1.9-0.41.40.22.02.4-2.0
Locomotor testing rearing0.20.82.5-0.9-0.5-0.7-0.70.80.1-0.80.5-1.1-0.20.70.21.51.6-1.5
Locomotion in novel chamber0.81.03.60.71.01.10.7-0.7-1.40.8-1.20.41.5-1.01.90.30.7-0.3
Locomotion in novel chamber post-restriction0.41.14.30.71.21.30.8-0.7-1.70.9-1.00.61.4-0.72.10.10.6-0.1
Fecal boli incidents, locomotor time 10.92.23.1-1.7-1.6-1.4-1.81.61.5-1.61.6-1.7-1.61.8-0.81.01.1-1.0
Change in fecal boli incidents, locomotor task4.14.46.72.62.32.22.3-2.6-1.92.5-2.02.21.8-2.31.4-1.6-1.81.6
Time >=10cm from walls, locomotor time 12.22.84.81.81.81.81.8-1.5-1.71.8-1.41.71.1-1.61.2-2.1-1.22.2
Bouts of movement, locomotor time 11.11.52.6-1.3-1.5-1.4-1.21.21.4-1.31.0-1.0-1.31.1-1.60.90.4-0.9
Total resting periods, locomotor time 11.01.11.6-1.2-1.3-1.2-1.11.11.1-1.20.9-0.9-1.01.0-1.20.90.5-0.9
Rest time, locomotor task time 10.71.02.7-1.1-1.0-0.7-0.91.10.4-1.10.5-1.0-0.20.80.11.61.6-1.5
Distance moved, locomotor task time 10.20.62.10.90.70.40.7-0.8-0.40.7-0.40.60.1-0.5-0.3-1.4-1.31.3
Vertical activity count, locomotor time 10.32.03.11.51.51.31.5-1.4-1.51.5-1.31.41.0-1.30.7-1.8-1.41.6
Time >=10cm from walls, locomotor time 20.10.21.10.20.20.20.2-0.0-0.00.3-0.10.5-0.5-0.3-0.4-1.0-0.71.0
Bouts of movement, locomotor time 20.72.33.91.61.51.51.9-1.5-1.41.5-2.01.91.7-1.80.9-0.8-1.10.8
Total resting periods, locomotor time 20.31.32.71.21.11.11.6-1.2-1.11.1-1.61.51.4-1.50.5-0.5-0.70.4
Rest time, locomotor task time 20.20.41.7-0.6-0.5-0.5-0.30.50.2-0.60.0-0.50.00.2-0.21.30.8-1.2
Distance moved, locomotor task time 20.20.30.6-0.6-0.5-0.5-0.50.60.5-0.50.5-0.4-0.70.4-0.8-0.7-0.30.6
Vertical activity count, locomotor time 20.10.20.4-0.6-0.5-0.3-0.60.70.4-0.40.4-0.4-0.70.3-0.3-0.60.00.6
Light reinforcement 10.73.44.32.12.02.02.0-2.1-1.91.9-1.71.81.7-1.71.4-1.8-1.41.9
Light reinforcement 21.84.15.42.02.22.32.1-1.9-2.32.1-2.32.12.2-2.22.1-1.5-1.01.6
Bone: marrow area1.23.03.8-1.9-2.0-1.9-1.81.91.8-1.91.8-1.5-1.91.7-1.91.21.0-1.2
Bone: maximum diameter7.214.518.9-4.4-4.2-4.2-4.24.34.3-4.14.1-3.8-4.33.8-3.81.82.5-1.8
Bone: maximum force2.24.36.8-2.6-2.2-2.1-2.42.61.8-2.32.1-2.2-1.92.2-1.31.32.2-1.3
Bone: maximum moment2.03.95.8-2.4-2.1-2.0-2.32.41.8-2.22.0-2.1-1.92.1-1.31.11.9-1.1
Mean time between licks in bursts0.00.31.10.40.30.30.5-0.40.30.50.00.3-0.3-0.2-0.3-1.1-0.81.1
Mean num. licks in bursts0.20.62.2-0.4-0.00.0-0.30.2-0.8-0.3-0.0-0.70.70.31.31.01.5-1.1
Cd content in liver1.11.24.10.81.21.30.9-0.8-1.80.9-1.20.71.5-0.82.00.10.3-0.1
Co content in liver0.30.42.2-0.0-0.00.2-0.20.0-0.4-0.1-0.1-0.20.50.30.91.50.7-1.5
Cu content in liver0.10.10.40.20.30.30.2-0.2-0.30.2-0.50.30.6-0.30.50.40.2-0.4
Fe content in liver0.81.02.7-0.8-1.0-1.0-0.90.91.6-0.71.1-0.5-1.60.9-1.6-0.4-0.30.4
K content in liver0.30.30.50.50.40.50.6-0.5-0.50.4-0.60.50.7-0.50.50.5-0.0-0.5
Mg content in liver0.50.61.30.80.70.71.0-0.7-0.70.7-1.11.00.9-1.00.40.3-0.4-0.3
Mn content in liver0.91.01.81.01.01.01.3-1.0-0.91.0-1.31.21.2-1.20.6-0.0-0.60.0
Na content in liver0.40.40.80.90.50.50.8-0.9-0.50.6-0.80.90.7-0.70.1-0.0-0.80.0
Rb content in liver2.22.64.71.91.71.51.9-1.7-0.91.7-1.92.21.1-1.90.5-1.4-1.71.4
Se content in liver0.70.81.41.00.80.81.0-0.9-1.00.9-0.91.20.6-0.90.3-0.9-0.90.9
Sr content in liver2.21.94.11.21.51.61.4-1.2-1.91.2-1.61.12.0-1.31.90.1-0.3-0.1
Zn content in liver1.01.12.50.91.01.21.1-0.9-1.20.9-1.61.11.6-1.21.20.3-0.2-0.3
Bone: minimum diameter3.26.19.2-2.9-2.8-2.7-2.62.93.0-2.72.5-2.2-2.82.3-2.71.11.4-1.0
Time in familiar zone, hab. session 10.10.10.2-0.1-0.0-0.0-0.20.0-0.0-0.10.3-0.50.00.40.40.30.3-0.4
Time in novel zone, hab. session 10.30.31.4-0.5-0.7-0.7-0.40.50.8-0.50.4-0.1-0.80.2-1.2-0.2-0.30.2
Total zone transitions, hab. session 11.01.42.7-1.5-1.2-1.2-1.31.40.3-1.30.9-1.4-0.41.1-0.31.21.6-1.3
Total locomotion distance, hab. session 10.40.51.00.70.80.70.7-0.7-0.70.8-0.60.60.5-0.60.5-1.0-0.61.0
Locomotion velocity, hab. session 10.60.81.20.91.00.91.0-1.0-1.01.0-0.80.80.8-0.80.8-1.1-0.71.0
Time in familiar zone, hab. session 21.31.54.7-0.7-1.1-1.4-1.10.71.9-0.91.5-0.9-1.71.2-2.2-0.0-0.70.1
Time in novel zone, hab. session 20.50.52.7-0.10.30.70.20.0-1.20.2-0.6-0.11.0-0.21.60.41.3-0.4
Total zone transitions, hab. session 21.41.82.8-1.6-1.4-1.4-1.41.40.7-1.61.3-1.7-0.61.5-0.61.51.6-1.5
Total locomotion distance, hab. session 20.00.00.1-0.20.0-0.10.0-0.0-0.1-0.10.2-0.30.10.20.10.00.2-0.0
Locomotion velocity, hab. session 20.00.00.1-0.00.10.00.2-0.1-0.30.0-0.0-0.10.3-0.10.20.00.2-0.1
Novel to familiar place preference ratio0.10.20.9-0.1-0.10.1-0.20.20.3-0.00.10.2-0.6-0.1-0.3-0.9-0.40.9
Novelty place preference0.10.10.6-0.3-0.20.0-0.30.30.3-0.10.20.1-0.70.0-0.2-0.7-0.20.7
Time in novel zone, NPP test0.30.41.2-0.6-0.5-0.4-0.60.60.8-0.50.6-0.2-1.10.4-0.8-0.7-0.20.7
Total zone transitions, NPP test0.30.41.1-0.9-0.6-0.6-0.50.70.2-0.70.3-0.70.10.4-0.21.10.9-1.1
Total locomotion distance, NPP test0.10.10.20.20.40.30.4-0.3-0.40.4-0.30.30.4-0.40.2-0.3-0.30.2
Locomotion velocity, NPP test0.40.61.00.60.90.80.9-0.7-1.00.8-0.80.70.9-0.80.8-0.3-0.30.3
Intraocular pressure4.16.69.7-2.7-2.8-2.9-3.02.72.8-2.73.1-2.8-2.82.9-2.51.11.5-1.1
Delta distance traveled before/after self-admin0.10.10.7-0.1-0.2-0.2-0.00.1-0.1-0.20.0-0.10.10.1-0.00.80.3-0.9
Delta ambulatory time before/after self-admin0.10.10.4-0.2-0.4-0.5-0.20.20.3-0.30.2-0.1-0.40.2-0.60.4-0.1-0.5
Parametrial fat weight12.730.040.7-5.9-6.2-6.2-6.05.76.4-5.96.2-5.4-6.05.8-6.03.02.5-3.0
Pavlov. Cond. lever latency0.10.10.60.1-0.2-0.3-0.0-0.00.4-0.10.10.1-0.5-0.1-0.7-0.1-0.70.1
Pavlov. Cond. magazine entry latency0.00.00.10.00.20.1-0.0-0.20.20.10.3-0.30.10.20.2-0.20.00.3
Pavlov. Cond. change in total contacts0.00.00.3-0.3-0.00.0-0.10.20.0-0.10.0-0.30.20.10.20.20.5-0.1
Pavlov. Cond. index score0.10.10.4-0.4-0.1-0.1-0.30.30.2-0.20.4-0.5-0.00.40.10.20.6-0.1
Pavlov. Cond. latency score0.10.10.5-0.4-0.1-0.1-0.30.30.1-0.30.3-0.50.00.40.20.30.7-0.2
Pavlov. Cond. lever contacts0.00.10.3-0.2-0.1-0.0-0.20.2-0.1-0.10.1-0.30.10.30.30.20.6-0.2
Pavlov. Cond. magazine entry number0.50.61.40.90.50.70.9-0.7-0.70.7-1.01.20.5-1.00.2-0.3-0.90.2
Pavlov. Cond. intertrial magazine entries0.20.20.6-0.6-0.4-0.3-0.80.50.1-0.30.6-0.6-0.60.60.1-0.00.40.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.2-0.3-0.0-0.1-0.30.20.3-0.10.3-0.4-0.10.30.1-0.00.40.1
Pavlov. Cond. response bias0.00.10.2-0.20.10.0-0.20.10.1-0.10.3-0.50.10.30.3-0.10.50.2
Pavlov. Cond. lever latency0.40.51.40.60.90.80.7-0.5-1.10.7-0.80.51.1-0.41.2-0.00.30.1
Pavlov. Cond. magazine entry latency0.30.41.5-0.4-0.7-0.9-0.60.30.8-0.50.7-0.5-0.80.4-1.20.0-0.20.0
Pavlov. Cond. change in total contacts0.51.12.5-0.9-1.2-1.3-1.20.81.4-1.01.3-1.0-1.60.9-1.4-0.0-0.00.0
Pavlov. Cond. index score0.71.12.1-0.9-1.2-1.3-1.20.81.3-1.11.3-1.0-1.41.0-1.40.20.0-0.2
Pavlov. Cond. latency score0.61.02.0-0.8-1.2-1.2-1.10.81.3-1.01.2-1.0-1.40.9-1.40.2-0.1-0.2
Pavlov. Cond. lever contacts0.30.40.7-0.6-0.9-0.8-0.70.60.8-0.70.7-0.6-0.80.5-0.80.40.0-0.4
Pavlov. Cond. magazine entry number0.30.31.30.40.60.80.5-0.3-0.80.5-0.70.50.8-0.41.1-0.20.20.1
Pavlov. Cond. intertrial magazine entries0.00.00.2-0.2-0.0-0.3-0.00.20.5-0.20.00.0-0.10.1-0.40.00.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.71.11.8-1.0-1.2-1.3-1.20.91.3-1.11.3-1.1-1.31.0-1.30.40.2-0.4
Pavlov. Cond. response bias0.50.71.6-0.8-1.0-1.0-0.90.71.1-0.81.0-0.8-1.20.7-1.30.1-0.0-0.1
Time in closed arm before self-admin0.20.30.60.80.50.50.7-0.7-0.50.5-0.80.70.7-0.70.3-0.3-0.40.3
Time in closed arm after self-admin1.51.73.31.31.31.41.5-1.2-1.41.3-1.81.41.7-1.51.60.3-0.2-0.3
Time in open arm before self-admin1.31.52.41.11.41.41.2-1.2-1.01.5-1.41.30.8-1.50.8-1.3-1.01.3
Time in open arm after self-admin0.60.71.7-0.7-0.8-0.7-0.90.80.9-0.91.3-0.7-1.11.1-0.8-0.50.20.4
Bone: periosteal estimation4.611.015.2-3.9-3.7-3.6-3.73.93.5-3.73.5-3.3-3.53.4-3.01.92.4-1.9
Bone: periosteal perimeter10.119.825.7-5.1-4.9-4.9-4.95.14.5-4.94.6-4.6-4.44.6-3.93.13.5-3.1
Bone: post-yield work0.20.41.60.30.50.50.5-0.30.20.6-0.40.70.1-0.6-0.1-1.2-0.91.3
Progressive ratio test 1 active lever presses0.61.02.4-1.2-0.9-1.0-1.11.10.2-1.10.6-1.1-0.20.9-0.11.41.6-1.4
Progressive ratio test 1 breakpoint0.61.12.7-1.3-0.9-1.0-1.11.20.2-1.20.6-1.1-0.10.9-0.01.41.7-1.4
Progressive ratio test 1 inactive lever presses0.00.10.2-0.4-0.3-0.5-0.50.30.2-0.30.3-0.4-0.20.4-0.20.40.3-0.3
Progressive ratio test 2 active lever presses1.31.82.7-1.6-1.5-1.7-1.51.40.8-1.51.1-1.5-0.81.3-0.91.41.3-1.3
Progressive ratio test 2 breakpoint1.51.92.9-1.6-1.6-1.7-1.61.40.9-1.61.2-1.5-0.91.3-1.01.41.3-1.3
Progressive ratio test 2 inactive lever presses0.72.13.1-1.6-1.6-1.6-1.81.51.7-1.51.5-1.5-1.41.6-1.20.90.8-0.9
Incentive Sensitization - Responses0.41.22.0-1.2-1.3-1.4-1.21.11.2-1.21.0-1.1-1.11.0-1.20.80.5-0.7
Incentive Sensitization - Breakpoint0.51.11.9-1.1-1.2-1.4-1.21.01.1-1.11.0-1.0-1.10.9-1.20.60.3-0.5
Sum of active levers in priming session hrs 5-60.20.20.50.60.40.40.4-0.5-0.50.4-0.30.60.3-0.30.1-0.7-0.60.7
Progressive ratio0.30.81.20.90.90.71.0-0.9-0.90.9-0.90.90.5-0.90.3-1.1-0.90.9
Food seeking constrained by brief footshock1.31.63.51.41.20.71.5-1.5-0.41.4-1.31.40.5-1.6-0.5-1.4-1.91.3
Seeking ratio, punishment vs. effort0.00.10.50.0-0.1-0.2-0.0-0.10.3-0.00.1-0.20.1-0.1-0.20.70.1-0.5
Retroperitoneal fat weight10.747.971.4-7.4-7.7-7.8-7.57.38.4-7.27.7-6.7-7.67.0-7.83.93.1-3.9
Reaction time number correct0.41.21.9-1.3-1.3-1.4-1.11.21.4-1.31.1-1.0-1.21.1-1.40.30.7-0.3
Reaction time mean minus median0.10.91.5-1.0-0.9-1.1-0.90.90.5-1.01.0-1.2-0.51.1-0.51.01.1-0.9
Reaction time mean minus median AUC0.10.82.5-0.8-0.6-0.8-0.60.7-0.1-0.80.6-1.10.10.80.11.61.4-1.5
Reaction time num false alarms0.10.10.4-0.3-0.00.1-0.10.3-0.2-0.0-0.1-0.10.2-0.10.20.70.5-0.6
Reaction time num false alarms AUC0.10.20.9-0.4-0.2-0.0-0.20.4-0.3-0.2-0.0-0.20.20.10.30.90.7-0.8
Reaction time trials correct on left0.41.21.9-1.3-1.3-1.4-1.11.21.4-1.31.1-1.0-1.21.1-1.40.30.7-0.3
Reaction time trials on left0.41.42.1-1.3-1.4-1.4-1.21.21.4-1.41.1-1.1-1.21.1-1.40.40.7-0.4
Reaction time mean0.40.92.0-1.0-0.8-0.9-0.80.80.5-0.90.9-1.2-0.21.0-0.21.41.2-1.4
Reaction time mean AUC0.20.41.3-0.6-0.4-0.4-0.30.40.2-0.50.5-0.70.10.60.11.10.9-1.1
Median of all reaction times0.40.72.1-0.8-0.6-0.6-0.60.70.3-0.70.7-1.0-0.00.80.01.41.1-1.4
Reaction time omissions0.40.61.1-0.6-1.0-1.0-0.80.60.9-0.90.9-0.7-0.80.8-1.00.70.2-0.7
Reaction time false alarm rate0.20.30.60.30.50.70.4-0.2-0.80.5-0.50.40.7-0.50.80.50.1-0.4
Reaction time premature initiation rate0.40.71.9-0.6-0.3-0.2-0.60.6-0.4-0.70.7-1.10.41.00.81.21.4-1.1
Reaction time premature initiations0.61.73.4-1.4-1.1-1.1-1.41.30.4-1.51.4-1.8-0.41.70.01.41.9-1.3
Std. dev. reaction times0.93.14.5-1.9-1.8-1.9-1.81.81.3-1.91.8-2.1-1.21.9-1.11.91.8-1.9
Reaction time trials completed0.41.42.1-1.3-1.4-1.4-1.21.21.4-1.41.1-1.1-1.21.1-1.40.40.7-0.4
Reaction time trials AUC0.41.52.2-1.4-1.4-1.5-1.31.31.5-1.41.2-1.2-1.31.2-1.40.40.8-0.5
Run reversals in cocaine runway, females1.41.62.5-1.3-1.2-1.1-1.51.20.7-1.31.4-1.6-0.71.5-0.11.41.4-1.4
Run reversals in cocaine runway, males2.22.43.31.81.61.51.7-1.8-1.21.5-1.71.71.2-1.80.7-1.3-1.71.4
Latency to leave start box in cocaine runway1.11.52.91.51.20.91.4-1.5-1.11.3-1.41.40.9-1.70.1-0.6-1.50.5
Latency to leave start box in cocaine runway, F1.82.33.81.81.61.31.7-1.7-1.31.6-1.81.71.0-2.00.4-1.2-1.71.2
Latency to leave start box in cocaine runway, M0.10.10.70.2-0.2-0.30.1-0.20.0-0.10.00.00.1-0.2-0.60.8-0.4-0.8
Std. dev. time between licks in bursts0.10.20.50.50.40.60.6-0.4-0.20.6-0.20.60.1-0.30.2-0.7-0.60.7
Total sessions with >9 infusions3.34.16.3-2.5-2.1-2.0-2.32.41.1-2.21.9-2.4-1.32.2-0.72.02.3-2.1
Short access day 1 total inactive lever presses0.20.51.40.70.60.30.5-0.70.00.8-0.60.8-0.2-0.7-0.2-0.9-1.20.9
Short access day 10 total inactive lever presses0.00.30.6-0.5-0.5-0.6-0.50.30.6-0.60.6-0.8-0.40.6-0.40.60.1-0.5
Short access day 1 total infusions0.20.41.5-0.7-0.4-0.3-0.50.6-0.2-0.50.1-0.70.20.40.41.11.2-1.2
Short access day 10 total infusions0.30.52.2-0.7-0.3-0.2-0.50.5-0.7-0.50.1-0.70.40.40.81.11.5-1.2
Short access total infusions0.71.03.2-1.2-0.8-0.7-1.01.1-0.2-0.90.6-1.2-0.11.00.51.41.8-1.3
Short access day 1 locomotion0.50.83.1-1.0-0.8-1.0-0.70.90.1-0.80.3-0.8-0.10.6-0.41.70.9-1.8
Short access day 10 total locomotion0.52.14.2-1.7-1.5-1.4-1.51.60.8-1.71.1-1.5-0.51.4-0.41.91.6-2.0
Short access total locomotion1.72.55.6-1.9-1.5-1.4-1.61.80.3-1.71.0-1.6-0.21.4-0.12.42.1-2.3
One hour access (0.3 mA shock)0.60.71.6-0.9-0.9-1.2-0.80.71.1-0.80.8-0.8-1.00.7-1.30.70.1-0.6
Compulsive drug intake0.30.41.80.70.40.30.6-0.70.40.6-0.30.7-0.2-0.6-0.7-0.8-1.30.9
One hour access (shock baseline)0.51.22.3-1.3-1.0-1.1-1.11.10.5-1.20.8-1.3-0.41.0-0.21.51.5-1.4
Social response proportion1.62.04.6-1.5-1.3-1.1-1.61.40.1-1.41.1-1.8-0.21.50.32.02.1-1.8
Social responses4.96.58.6-2.8-2.9-2.9-2.92.62.2-2.92.8-2.9-2.32.8-2.12.01.9-1.8
Social time1.21.93.9-1.5-1.5-1.4-1.51.30.5-1.41.0-1.6-0.61.2-0.42.01.6-1.8
Soleus weight3.49.913.9-3.6-3.1-3.1-3.13.42.4-3.42.9-3.6-1.83.2-1.73.73.6-3.7
Bone: stiffness1.83.25.4-2.3-1.9-1.7-1.92.31.5-2.01.7-2.0-1.51.9-0.91.32.1-1.2
Tibialis anterior weight0.31.02.2-0.9-1.2-1.0-0.91.11.5-1.11.0-0.6-1.20.9-1.4-0.00.4-0.0
Time to tail flick, vehicle, before self-admin0.40.51.2-0.7-0.9-0.9-1.10.60.8-0.80.7-0.7-1.00.7-0.60.00.3-0.0
Time to tail flick, vehicle, after self-admin0.20.31.10.40.50.30.5-0.4-0.20.6-0.70.70.1-0.6-0.1-1.0-0.70.7
Time to tail flick, test, before self-admin1.11.24.2-0.30.00.10.00.3-1.4-0.3-0.1-0.71.30.61.52.01.7-2.1
Time to tail flick, test, after self-admin1.21.21.9-1.2-1.3-1.2-1.31.41.1-1.31.2-1.0-1.31.2-1.1-0.20.60.2
Delta time to tail flick, vehicle, before/after SA0.20.20.70.10.1-0.10.3-0.00.30.2-0.00.4-0.2-0.1-0.8-0.6-0.80.5
Delta time to tail flick, test, before/after SA1.31.73.6-1.3-1.4-1.2-1.61.41.7-1.31.3-1.1-1.91.1-1.4-0.70.20.7
Tibia length1.33.75.3-2.1-2.0-2.0-2.22.01.0-2.21.9-2.3-1.22.1-0.82.02.2-2.1
Ambulatory time before self-admin0.20.52.0-0.00.50.40.2-0.1-1.00.2-0.5-0.21.2-0.31.40.81.1-0.6
Ambulatory time after self-admin0.30.51.60.20.40.40.3-0.3-1.20.2-0.6-0.11.2-0.31.20.91.0-0.9
Bone: tissue strength0.30.30.60.70.50.40.7-0.7-0.20.7-0.60.70.3-0.70.0-0.5-0.80.5
Total heroin consumption1.11.32.7-1.1-1.3-1.5-1.21.21.1-1.21.3-1.0-1.31.2-1.70.20.3-0.2
Bone: trabecular number0.71.43.8-1.0-1.2-1.1-1.11.21.9-0.91.2-0.6-1.70.8-1.8-0.8-0.30.8
Bone: trabecular spacing0.10.20.40.60.50.40.5-0.7-0.30.5-0.50.50.3-0.50.2-0.2-0.50.2
Bone: trabecular thickness4.56.38.3-2.8-2.8-2.8-2.62.92.9-2.72.7-2.4-2.82.5-2.81.31.3-1.3
Bone: trabecular tissue density0.50.82.4-1.0-0.6-0.5-0.70.9-0.1-0.80.6-1.1-0.20.80.41.51.5-1.5
Water consumed over 24 hours0.10.20.5-0.4-0.3-0.3-0.40.40.1-0.40.3-0.6-0.00.40.30.60.7-0.5
Number of responses in last shaping day0.30.42.0-0.4-0.3-0.2-0.40.4-0.2-0.40.2-0.60.50.50.71.41.0-1.2