Hub : Genes

Afap1l2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio XM_017588861.2 0.06 0.06 1.5e-03 0.04 0.03 0.04 0.04 9.2e-05 4.5e-04 2.4e-04 1.7e-04
2 LHb mRNA stability Afap1l2 0.48 0.19 2.0e-07 0.32 0.26 0.26 0.26 1.7e-08 6.7e-07 8.0e-07 5.2e-07
3 Adipose mRNA stability Afap1l2 0.03 0.02 5.7e-04 0.02 0.02 0.04 0.03 1.7e-03 1.5e-03 5.6e-05 2.1e-04
4 Brain isoform ratio NM_001305184.1 0.08 0.07 5.8e-03 0.03 0.02 0.02 0.03 5.9e-04 3.3e-03 5.2e-03 1.0e-03
5 IL mRNA stability Afap1l2 0.27 0.16 4.2e-04 0.2 0.12 0.15 0.15 1.1e-05 9.3e-04 2.2e-04 1.7e-04
6 pVTA mRNA stability Afap1l2 0.27 0.12 3.0e-12 0.3 0.28 0.29 0.3 1.7e-13 1.4e-12 6.1e-13 2.8e-13
7 NAcc mRNA stability Afap1l2 0.15 0.07 1.7e-16 0.14 0.13 0.13 0.13 6.7e-16 5.4e-15 1.0e-14 3.4e-15
8 Brain mRNA stability Afap1l2 0.54 0.13 0.0e+00 0.44 0.44 0.42 0.43 2.9e-45 6.7e-45 2.4e-42 6.2e-44
9 OFC mRNA stability Afap1l2 0.61 0.15 1.4e-08 0.36 0.36 0.37 0.36 2.3e-09 2.4e-09 1.1e-09 1.7e-09
10 Brain gene expression Afap1l2 0.21 0.09 0.0e+00 0.15 0.21 0.22 0.22 3.3e-14 3.2e-19 4.5e-20 1.7e-20
11 PL mRNA stability Afap1l2 0.23 0.1 0.0e+00 0.2 0.18 0.18 0.19 4.6e-21 1.8e-19 1.4e-19 7.5e-21
12 NAcc gene expression Afap1l2 0.06 0.04 6.2e-06 0.01 0.05 0.04 0.04 7.8e-03 3.3e-06 1.2e-05 2.8e-05
13 Adipose gene expression Afap1l2 0.04 0.03 9.8e-05 0.03 0.02 0.02 0.02 7.8e-04 1.5e-03 5.1e-03 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density2.33.86.12.12.1-1.6-1.92.01.91.91.92.5-2.51.6-2.40.3
Area under the delay curve0.50.61.50.70.7-1.2-0.60.40.50.40.40.6-1.10.4-1.2-0.9
BMI with tail9.430.436.66.16.1-6.0-5.85.75.65.65.45.5-5.55.2-4.9-4.0
BMI without tail4.08.310.13.13.1-3.2-2.92.92.93.02.82.9-3.22.6-3.0-1.7
Body weight9.539.746.86.76.7-6.8-6.66.56.56.56.36.2-6.36.0-5.5-4.8
Weight adjusted by age8.49.512.43.13.1-3.4-3.23.23.23.33.32.8-2.63.5-2.4-2.7
Bone surface1.32.33.31.81.8-1.4-1.61.61.71.51.51.8-1.51.1-1.5-0.1
Bone volume3.35.77.42.62.6-2.3-2.42.52.52.42.42.7-2.62.0-2.5-0.6
Breakpoint value in progressive ratio session0.20.20.7-0.4-0.40.10.5-0.5-0.4-0.5-0.5-0.2-0.3-0.7-0.50.8
Number of licking bursts0.20.21.10.10.1-0.2-0.20.20.20.20.10.6-0.80.2-1.00.7
Context. condit. distance diff. score2.32.83.8-1.8-1.81.61.9-1.9-1.9-2.0-1.8-1.81.3-1.71.40.6
Locomotion velocity, session 10.10.10.4-0.2-0.20.10.1-0.1-0.1-0.0-0.1-0.20.4-0.10.4-0.7
Locomotion distance, session 10.20.21.50.10.1-0.3-0.30.30.40.30.2-0.20.50.40.7-1.2
Locomotion velocity, session 20.30.42.0-0.1-0.10.30.1-0.1-0.1-0.1-0.1-0.61.2-0.01.4-0.9
Locomotion distance, session 21.01.54.01.31.3-1.2-1.31.31.31.21.10.7-0.41.20.1-2.0
Locomotion velocity, session 30.10.10.8-0.1-0.10.20.2-0.2-0.1-0.10.0-0.40.90.10.8-0.3
Locomotion distance, session 30.50.51.5-0.5-0.50.50.5-0.6-0.5-0.6-0.4-0.91.2-0.41.2-0.8
Stereotopy head waving bouts, day 30.20.30.80.60.6-0.0-0.50.60.50.50.50.7-0.10.3-0.40.9
Stereotopy head waving duration, day 30.20.22.40.20.20.3-0.10.20.10.10.20.5-0.10.1-0.41.6
Locomotion velocity, session 70.20.30.40.60.6-0.6-0.40.40.40.30.50.4-0.60.6-0.4-0.7
Locomotion distance, session 70.10.10.4-0.1-0.10.10.4-0.4-0.4-0.4-0.3-0.4-0.2-0.30.3-0.6
Stereotopy head waving bouts, day 70.10.10.10.40.4-0.1-0.30.30.30.30.30.30.20.3-0.00.1
Stereotopy head waving duration, day 71.31.52.01.41.4-1.4-1.41.41.41.41.31.2-0.71.1-1.0-0.6
Locomotion velocity, session 82.63.14.2-1.7-1.71.81.8-1.8-1.8-1.8-2.0-1.81.7-2.01.61.2
Locomotion distance, session 81.72.43.7-1.6-1.61.61.6-1.6-1.6-1.6-1.6-1.71.6-1.41.90.2
Degree of sensitization distance0.40.40.6-0.4-0.40.30.7-0.7-0.7-0.7-0.7-0.3-0.7-0.7-0.40.8
Degree of sensitization stereotypy0.10.10.20.30.3-0.4-0.30.30.30.30.30.2-0.10.3-0.2-0.3
Conditioned locomotion0.10.10.4-0.2-0.20.30.1-0.4-0.3-0.4-0.4-0.40.6-0.30.6-0.1
Cocaine response after cond. corrected2.22.45.1-1.5-1.51.31.5-1.4-1.5-1.2-1.1-2.02.2-1.42.3-0.3
Cocaine response after cond. not corrected2.83.15.2-1.8-1.81.71.7-1.7-1.7-1.6-1.4-2.12.3-1.62.30.3
Cocaine response before conditioning0.30.42.2-0.5-0.50.60.5-0.5-0.4-0.6-0.50.1-0.3-0.3-0.41.5
Saline control response0.10.20.40.60.6-0.1-0.60.30.50.30.30.20.60.20.5-0.2
Bone: connectivity density0.20.40.80.70.7-0.2-0.40.50.50.40.40.9-0.90.1-0.80.9
Bone: cortical apparent density0.70.93.7-0.4-0.40.60.4-0.4-0.4-0.5-0.5-1.31.8-0.51.9-0.8
Bone: cortical area11.317.020.44.54.5-4.1-4.44.44.44.34.24.4-4.14.0-3.7-1.8
Bone: cortical porosity0.10.21.20.10.10.2-0.20.20.10.30.20.6-0.30.1-0.51.1
Bone: cortical porosity0.20.21.60.20.20.2-0.20.10.10.20.10.6-0.5-0.0-0.71.2
Bone: cortical thickness5.18.410.73.33.3-2.8-3.23.23.13.13.13.0-2.52.9-2.3-1.2
Bone: cortical thickness1.51.72.31.41.4-1.3-1.51.51.41.41.41.1-0.91.4-0.7-1.2
Bone: cortical tissue density0.91.24.4-0.7-0.70.80.7-0.6-0.7-0.7-0.7-1.52.0-0.72.1-0.7
Condit. Reinf. active minus inactive responses0.10.20.6-0.3-0.30.60.2-0.3-0.2-0.3-0.2-0.10.5-0.10.50.8
Condit. Reinf. active-inactive response ratio0.20.20.9-0.4-0.40.70.3-0.4-0.3-0.3-0.3-0.10.3-0.20.30.9
Condit. Reinf. active responses0.91.11.91.01.0-0.7-1.31.21.31.21.21.4-0.61.2-0.70.1
Condit. Reinf. inactive responses2.73.24.71.81.8-1.5-2.02.12.12.02.02.2-1.41.8-1.4-0.5
Incentive salience index mean0.20.20.7-0.3-0.30.70.2-0.2-0.2-0.3-0.2-0.20.8-0.00.80.5
Condit. Reinf. lever presses0.00.00.20.10.10.1-0.20.20.20.20.20.10.30.20.5-0.1
Condit. Reinf. active minus inactive responses2.63.36.81.61.6-1.3-1.61.71.51.71.82.4-2.22.0-2.60.5
Condit. Reinf. active-inactive response ratio0.80.82.30.50.5-0.6-0.50.80.60.81.01.2-1.21.2-1.50.5
Condit. Reinf. active responses4.35.910.62.42.4-2.2-2.42.32.22.32.43.0-2.92.4-3.3-0.1
Condit. Reinf. inactive responses1.82.23.31.71.7-1.5-1.61.41.51.31.31.7-1.71.1-1.8-0.5
Condit. Reinf. lever presses0.60.82.10.80.8-1.0-0.80.70.70.70.71.1-1.10.6-1.4-0.1
Condit. Reinf. lever reinforcers received2.94.07.51.91.9-1.8-1.91.91.81.92.02.5-2.42.0-2.70.1
Conditioned reinforcement - actives0.40.42.1-0.2-0.20.30.2-0.1-0.2-0.1-0.1-0.81.3-0.41.4-0.8
Conditioned reinforcement - inactives0.20.30.80.50.5-0.6-0.50.50.40.60.60.3-0.40.5-0.2-0.9
Conditioned locomotion0.40.41.9-0.4-0.40.50.3-0.3-0.3-0.3-0.2-0.81.2-0.61.4-0.5
Patch foraging indifference point 0 sec5.58.810.83.23.2-3.3-3.33.13.12.92.83.0-2.62.8-2.7-2.3
Patch foraging indifference point AUC1.21.41.81.21.2-1.1-1.11.31.31.21.31.3-1.30.9-1.3-0.3
Delay disc. indifference point, 0s delay0.20.20.70.70.7-0.8-0.60.30.30.20.20.2-0.40.0-0.3-0.8
Delay disc. indifference point, 16s delay0.10.10.60.10.1-0.6-0.0-0.2-0.0-0.2-0.20.1-0.7-0.2-0.8-0.5
Delay disc. indifference point, 2s delay0.50.51.0-0.7-0.70.10.7-0.9-0.8-0.9-0.9-1.00.4-0.90.4-0.4
Delay disc. indifference point, 24s delay0.40.42.20.30.3-0.6-0.20.30.30.30.30.7-1.50.3-1.4-0.2
Delay disc. indifference point, 4s delay0.50.51.0-0.6-0.60.20.7-1.0-1.0-1.0-1.0-0.90.1-0.90.1-0.0
Delay disc. indifference point, 8s delay5.86.08.72.62.6-3.0-2.52.42.52.42.42.3-2.32.2-2.4-2.2
Indifference point function ln k0.00.10.3-0.0-0.00.30.0-0.1-0.0-0.1-0.2-0.10.50.30.50.3
Indifference point function log k0.00.10.3-0.0-0.00.30.0-0.1-0.0-0.1-0.2-0.10.50.30.50.3
Patch foraging total patch changes 0 sec5.38.610.63.23.2-3.3-3.23.03.12.92.83.0-2.72.7-2.7-2.2
Patch foraging total patch changes 12 sec1.92.43.61.61.6-1.9-1.71.51.61.31.31.7-1.81.0-1.9-1.0
Patch foraging total patch changes 18 sec5.26.78.72.62.6-2.7-2.62.72.72.62.62.9-2.82.2-2.9-1.0
Patch foraging total patch changes 24 sec4.04.87.12.42.4-2.6-2.32.12.22.12.02.3-2.51.6-2.7-1.0
Patch foraging total patch changes 6 sec7.010.311.83.33.3-3.4-3.43.43.43.23.33.4-3.32.9-3.3-1.9
Patch foraging time to switch 0 sec1.01.52.0-1.3-1.31.01.3-1.4-1.4-1.4-1.3-1.40.9-1.31.00.3
Patch foraging water rate 0 sec1.21.92.81.51.5-1.4-1.71.61.61.51.41.5-0.91.3-1.1-0.5
Patch foraging water rate 12 sec2.74.26.12.22.2-2.0-2.12.12.11.91.92.5-2.31.9-2.3-0.1
Patch foraging water rate 18 sec0.71.01.41.11.1-1.1-1.21.11.01.21.10.8-0.51.1-0.4-1.0
Patch foraging water rate 24 sec1.11.52.11.41.4-1.4-1.41.31.41.21.21.1-0.71.2-0.6-1.2
Patch foraging water rate 6 sec0.71.01.71.31.3-1.2-1.31.11.21.10.90.8-0.30.8-0.4-0.8
Seeking ratio, delayed vs. immediate footshock0.80.91.6-0.8-0.81.21.0-1.0-1.0-1.0-0.8-1.01.1-0.81.30.1
Distance traveled before self-admin1.11.12.4-0.8-0.80.60.8-1.0-1.0-1.1-1.1-1.51.5-1.31.4-0.3
Distance traveled after self-admin0.50.62.3-0.3-0.30.40.3-0.5-0.5-0.6-0.6-1.01.4-0.51.5-0.6
Extensor digitorum longus weight0.62.44.31.81.8-1.6-1.71.41.51.21.21.8-2.11.3-1.9-0.2
Bone: elastic displacement0.30.40.6-0.8-0.80.50.7-0.6-0.8-0.6-0.6-0.60.2-0.70.10.4
Bone: elastic work0.50.61.00.90.9-0.8-0.91.00.90.90.90.5-0.10.7-0.1-0.8
Bone: endosteal estimation1.94.15.02.12.1-2.2-2.12.12.22.02.02.2-2.11.9-1.9-1.5
Bone: endosteal perimeter5.912.313.83.73.7-3.7-3.63.63.73.63.63.4-3.33.4-3.0-2.8
Epididymis fat weight13.732.036.06.06.0-5.9-5.85.75.75.75.75.8-6.05.8-5.1-4.2
Delta time in closed arm before/after self-admin0.50.40.9-0.4-0.40.70.4-0.6-0.5-0.7-0.7-0.70.9-1.00.9-0.3
Delta time in open arm before/after self-admin0.50.51.10.50.5-0.5-0.50.60.60.70.70.9-1.10.8-1.00.3
Diff in mean of infusions in LGA sessions3.13.44.7-2.1-2.11.62.1-2.2-2.1-2.1-2.1-1.50.8-1.80.42.0
Delay discount exponential model param0.50.61.5-0.6-0.61.20.5-0.4-0.4-0.4-0.4-0.61.1-0.51.20.9
Extinction: sum of active levers before priming1.21.21.8-1.3-1.30.91.3-1.3-1.2-1.3-1.3-0.90.4-1.10.10.9
Active lever presses in extinction session 60.50.51.2-0.8-0.80.60.8-0.6-0.6-0.7-0.7-0.50.5-0.7-0.11.1
Bone: final force4.57.39.43.03.0-2.8-3.03.13.02.92.92.7-2.22.5-1.9-1.8
Bone: final moment4.47.18.92.92.9-2.7-2.93.02.92.92.82.6-2.22.5-1.9-1.8
Food consumed during 24 hour testing period1.11.31.9-1.3-1.31.41.2-1.2-1.2-1.2-1.1-0.90.8-1.10.61.4
Glucose4.77.18.42.82.8-2.6-2.92.82.82.82.82.8-2.72.7-2.4-1.4
Heart weight2.94.25.22.12.1-2.3-2.22.12.12.12.21.8-1.82.2-1.5-1.9
Delay discount hyperbolic model param0.30.30.9-0.4-0.40.90.3-0.2-0.2-0.2-0.2-0.30.9-0.20.90.9
Intermittent access intake day 1-15 change1.71.72.51.41.4-1.6-1.31.31.21.31.31.1-1.21.2-1.4-0.8
Intermittent access intake escalation1.81.82.61.51.5-1.6-1.31.41.31.51.50.8-0.81.4-0.8-1.6
Intermittent access intake escalation 20.50.51.60.80.8-0.9-0.70.70.60.80.80.2-0.10.7-0.0-1.3
Intermitt. access day 1 inactive lever presses2.12.23.61.51.5-1.7-1.41.41.31.41.41.6-1.91.3-1.9-0.6
Intermitt. access day 15 inactive lever presses0.00.00.20.00.0-0.3-0.10.1-0.00.20.3-0.0-0.30.4-0.3-0.2
Intermitt. access escalation Index0.60.50.7-0.6-0.60.70.7-0.8-0.7-0.7-0.8-0.90.7-0.80.7-0.2
Intermittent access day 1 total infusions0.10.10.50.30.3-0.5-0.40.20.20.20.20.10.00.10.1-0.7
Intermittent access day 15 total infusions0.40.41.60.70.7-1.0-0.60.50.50.50.60.1-0.10.4-0.1-1.3
Intermittent access terminal intake (last 3 days)0.20.20.90.50.5-0.8-0.50.40.40.40.4-0.00.10.20.0-1.0
Intermittent access total infusions0.80.92.21.01.0-1.2-1.00.90.91.01.00.4-0.20.8-0.1-1.5
Intermittent access day 1 locomotion0.20.20.9-0.1-0.1-0.30.0-0.1-0.1-0.1-0.1-0.70.7-0.50.9-1.0
Intermittent access day 15 total locomotion2.52.74.21.71.7-2.1-1.71.81.71.81.91.5-1.41.5-1.6-1.0
Intermittent access total locomotion0.60.72.70.70.7-1.1-0.80.90.80.91.00.00.30.50.4-1.6
Intermittent access standard deviation0.60.61.20.90.9-1.0-0.80.50.50.50.60.7-1.10.6-1.0-0.6
Left kidney weight1.44.016.31.91.9-2.0-2.12.02.01.92.00.7-0.01.80.7-4.0
Right kidney weight5.114.327.64.04.0-4.0-4.24.04.14.04.02.7-2.13.8-0.9-5.3
Cocaine induced anxiety7.58.711.0-3.1-3.13.33.0-2.9-3.0-2.9-3.0-3.03.0-3.03.01.8
Post-drug Anxiety2.02.23.1-1.5-1.51.81.5-1.4-1.4-1.4-1.7-1.51.6-1.41.51.2
Baseline Anxiety7.27.79.02.92.9-2.9-2.72.82.92.72.73.0-3.02.9-3.0-1.2
Tail length0.10.20.70.30.3-0.3-0.40.40.40.60.50.6-0.70.3-0.80.2
Length with tail1.86.68.02.52.5-2.7-2.72.82.72.82.82.6-2.42.6-2.0-2.2
Length without tail5.111.113.33.43.4-3.4-3.63.63.63.53.63.3-2.93.5-2.3-2.8
Times rat made contact with spout0.00.00.20.10.1-0.2-0.10.20.10.20.3-0.10.20.20.2-0.4
Lifetime Intake0.91.02.51.11.1-1.2-1.11.01.01.01.10.5-0.30.9-0.0-1.6
Liver weight, left3.15.05.82.42.4-2.4-2.32.22.32.22.32.3-2.42.1-2.4-1.4
Liver weight, right6.410.612.43.53.5-3.5-3.43.23.33.33.43.1-3.23.1-2.9-2.9
Locomotor activity1.32.03.01.71.7-1.5-1.71.61.71.41.41.3-0.71.4-0.7-1.4
Locomotor testing distance1.52.43.51.81.8-1.6-1.91.81.91.61.61.2-0.31.6-0.2-1.8
Locomotor testing rearing0.40.61.80.80.8-0.8-0.90.70.90.50.70.4-0.10.8-0.1-1.3
Locomotion in novel chamber0.60.72.0-0.9-0.90.80.8-0.6-0.6-0.6-0.6-1.21.1-0.51.4-0.3
Locomotion in novel chamber post-restriction0.70.93.6-0.6-0.61.00.6-0.4-0.4-0.5-0.5-0.91.9-0.51.9-0.4
Fecal boli incidents, locomotor time 12.62.93.81.91.9-1.5-1.81.71.71.81.81.9-1.82.0-1.4-0.7
Change in fecal boli incidents, locomotor task4.94.66.7-2.6-2.62.52.5-2.3-2.3-2.2-2.1-2.01.5-2.01.31.7
Time >=10cm from walls, locomotor time 12.82.84.4-1.8-1.82.01.8-1.6-1.6-1.5-1.5-1.31.7-1.71.22.1
Bouts of movement, locomotor time 11.21.31.91.21.2-1.3-1.11.21.21.21.11.2-1.31.0-1.4-0.4
Total resting periods, locomotor time 11.01.11.31.11.1-1.1-1.01.11.21.11.01.1-1.00.9-1.0-0.5
Rest time, locomotor task time 10.80.91.31.01.0-0.9-1.01.11.11.11.00.5-0.20.90.2-1.2
Distance moved, locomotor task time 10.50.61.2-0.9-0.90.50.8-0.9-0.8-0.9-0.9-0.50.2-0.5-0.31.1
Vertical activity count, locomotor time 12.02.12.6-1.6-1.61.41.5-1.6-1.5-1.6-1.6-1.41.4-1.30.81.5
Time >=10cm from walls, locomotor time 20.10.11.0-0.2-0.20.40.2-0.2-0.1-0.2-0.20.30.1-0.5-0.41.0
Bouts of movement, locomotor time 22.22.34.4-1.4-1.41.11.5-1.8-1.6-1.7-1.8-1.71.4-2.11.20.8
Total resting periods, locomotor time 21.41.53.1-1.1-1.10.71.2-1.4-1.3-1.4-1.5-1.51.1-1.80.90.5
Rest time, locomotor task time 20.20.20.80.40.4-0.6-0.40.40.50.30.30.1-0.20.4-0.1-0.9
Distance moved, locomotor task time 20.30.30.70.60.6-0.5-0.60.50.50.50.50.8-0.70.5-0.80.4
Vertical activity count, locomotor time 20.30.40.70.70.7-0.3-0.80.60.60.70.60.8-0.50.4-0.50.4
Light reinforcement 11.83.23.9-1.8-1.81.81.7-1.9-1.7-2.0-1.9-1.61.8-1.81.51.7
Light reinforcement 22.73.64.5-1.9-1.92.01.8-1.9-1.9-1.9-1.9-2.02.0-2.12.01.3
Bone: marrow area2.04.25.22.12.1-2.2-2.22.12.32.02.02.2-2.11.9-1.9-1.5
Bone: maximum diameter9.116.820.14.44.4-4.0-4.34.24.34.24.24.5-4.34.0-4.1-1.7
Bone: maximum force3.86.58.52.82.8-2.5-2.92.92.92.72.72.6-2.12.4-1.8-1.5
Bone: maximum moment3.66.17.82.72.7-2.4-2.82.82.72.72.72.6-2.12.4-1.8-1.4
Mean time between licks in bursts0.10.20.8-0.4-0.40.60.5-0.3-0.5-0.3-0.40.1-0.3-0.2-0.30.9
Mean num. licks in bursts0.30.31.70.30.3-0.1-0.20.20.20.30.4-0.40.80.31.1-1.3
Cd content in liver2.42.63.4-1.7-1.71.81.6-1.7-1.7-1.7-1.6-1.41.5-1.61.21.6
Co content in liver0.10.10.70.20.2-0.1-0.30.30.40.30.20.00.50.30.6-0.8
Cu content in liver0.20.30.50.40.4-0.6-0.70.60.70.50.50.3-0.00.50.0-0.7
Fe content in liver0.10.10.40.10.10.1-0.30.40.30.10.20.5-0.00.3-0.20.6
K content in liver0.20.20.4-0.4-0.40.30.4-0.4-0.4-0.6-0.6-0.40.2-0.50.4-0.0
Mg content in liver0.10.10.2-0.1-0.1-0.00.2-0.2-0.3-0.4-0.3-0.1-0.2-0.3-0.20.1
Mn content in liver1.21.42.1-1.1-1.11.01.1-1.3-1.2-1.4-1.5-1.41.1-1.51.10.3
Na content in liver0.20.20.4-0.3-0.30.10.3-0.5-0.4-0.6-0.6-0.2-0.1-0.6-0.20.6
Rb content in liver1.62.02.6-1.5-1.51.31.5-1.6-1.5-1.6-1.6-1.30.9-1.60.71.1
Se content in liver0.10.10.60.10.1-0.1-0.30.10.20.0-0.10.3-0.0-0.0-0.30.7
Sr content in liver2.42.24.0-1.3-1.31.21.3-1.5-1.4-1.5-1.5-1.81.9-1.52.00.1
Zn content in liver1.92.13.1-1.3-1.31.21.4-1.5-1.4-1.5-1.5-1.81.7-1.61.70.3
Bone: minimum diameter4.17.69.43.03.0-2.8-3.02.83.02.72.73.1-2.92.5-2.8-1.1
Time in familiar zone, hab. session 10.10.10.20.30.3-0.0-0.20.10.10.10.20.1-0.00.50.2-0.4
Time in novel zone, hab. session 10.30.31.10.40.4-0.6-0.40.50.40.50.40.6-0.90.2-1.10.3
Total zone transitions, hab. session 11.11.63.51.31.3-1.5-1.31.31.41.31.20.7-0.51.3-0.3-1.9
Total locomotion distance, hab. session 10.40.50.8-0.9-0.90.90.8-0.8-0.7-0.8-0.8-0.60.8-0.50.50.6
Locomotion velocity, hab. session 10.70.91.2-1.1-1.11.11.0-1.0-1.0-1.1-1.0-0.91.0-0.70.80.7
Time in familiar zone, hab. session 21.11.13.90.60.6-0.9-0.70.70.70.80.81.3-2.01.1-2.00.2
Time in novel zone, hab. session 20.30.31.80.10.10.2-0.10.10.10.00.0-0.51.2-0.21.4-0.6
Total zone transitions, hab. session 21.52.03.91.61.6-1.7-1.41.31.41.31.31.0-1.01.6-0.7-2.0
Total locomotion distance, hab. session 20.00.00.10.00.0-0.00.1-0.1-0.1-0.1-0.1-0.00.10.30.0-0.3
Locomotion velocity, hab. session 20.00.00.1-0.1-0.10.10.2-0.3-0.2-0.2-0.3-0.20.20.10.2-0.3
Novel to familiar place preference ratio0.10.10.70.20.20.1-0.20.20.20.10.30.6-0.5-0.0-0.50.8
Novelty place preference0.10.10.50.30.30.1-0.30.30.30.20.30.6-0.50.1-0.40.7
Time in novel zone, NPP test0.50.51.00.60.6-0.3-0.60.60.60.50.71.0-1.00.4-0.90.6
Total zone transitions, NPP test0.40.53.00.70.7-0.9-0.50.50.50.50.40.2-0.50.5-0.2-1.7
Total locomotion distance, NPP test0.10.10.3-0.4-0.40.30.5-0.4-0.4-0.4-0.5-0.30.4-0.30.2-0.2
Locomotion velocity, NPP test0.50.71.0-0.8-0.80.80.9-0.9-0.9-0.9-0.9-0.91.0-0.70.9-0.1
Intraocular pressure5.17.18.52.72.7-2.6-2.72.72.72.82.82.9-2.92.8-2.9-0.7
Delta distance traveled before/after self-admin0.10.10.70.20.2-0.3-0.30.30.30.30.30.20.00.50.1-0.9
Delta ambulatory time before/after self-admin0.10.10.30.20.2-0.3-0.30.40.40.40.40.4-0.30.5-0.3-0.4
Parametrial fat weight9.618.725.44.24.2-4.5-4.34.34.34.34.54.7-5.04.3-4.8-1.9
Pavlov. Cond. lever latency0.10.10.5-0.2-0.2-0.10.0-0.00.0-0.0-0.00.2-0.40.1-0.70.2
Pavlov. Cond. magazine entry latency0.00.00.1-0.1-0.10.30.3-0.2-0.3-0.2-0.2-0.2-0.10.00.2-0.2
Pavlov. Cond. change in total contacts0.00.00.10.30.3-0.1-0.10.00.10.10.0-0.0-0.00.00.2-0.2
Pavlov. Cond. index score0.00.00.10.30.3-0.1-0.10.20.10.20.20.1-0.30.30.1-0.3
Pavlov. Cond. latency score0.00.10.10.40.4-0.2-0.20.20.20.20.20.1-0.20.30.1-0.4
Pavlov. Cond. lever contacts0.00.00.10.30.3-0.2-0.20.20.20.20.30.1-0.10.10.1-0.1
Pavlov. Cond. magazine entry number0.30.40.7-0.7-0.70.40.6-0.6-0.6-0.6-0.7-0.60.7-0.80.30.4
Pavlov. Cond. intertrial magazine entries0.30.30.60.40.4-0.3-0.70.80.80.70.80.70.20.6-0.10.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.20.30.3-0.1-0.10.10.10.10.10.1-0.40.2-0.0-0.1
Pavlov. Cond. response bias0.00.00.10.20.20.0-0.10.20.10.20.20.0-0.10.30.2-0.2
Pavlov. Cond. lever latency0.50.61.5-0.8-0.80.80.8-0.7-0.7-0.8-0.7-1.01.0-0.41.20.0
Pavlov. Cond. magazine entry latency0.30.31.00.50.5-0.7-0.50.30.40.40.50.6-1.00.6-1.0-0.1
Pavlov. Cond. change in total contacts1.01.32.41.21.2-1.0-1.11.01.01.11.11.4-1.41.0-1.5-0.1
Pavlov. Cond. index score1.01.32.01.21.2-1.2-1.21.11.11.11.11.3-1.31.0-1.4-0.3
Pavlov. Cond. latency score0.91.11.81.01.0-1.1-1.11.01.01.01.01.2-1.30.9-1.4-0.2
Pavlov. Cond. lever contacts0.40.60.90.90.9-0.9-0.80.80.70.80.70.9-0.70.5-0.9-0.4
Pavlov. Cond. magazine entry number0.20.30.9-0.4-0.40.60.4-0.3-0.3-0.4-0.5-0.50.9-0.50.90.2
Pavlov. Cond. intertrial magazine entries0.00.00.20.10.1-0.3-0.1-0.10.0-0.1-0.00.1-0.50.1-0.5-0.1
Pavlov. Cond. lever-magazine prob. diff.1.01.21.61.11.1-1.1-1.11.11.11.11.11.2-1.21.0-1.3-0.4
Pavlov. Cond. response bias0.60.81.50.90.9-1.0-0.90.80.80.90.81.0-1.10.7-1.2-0.3
Time in closed arm before self-admin0.10.10.3-0.2-0.2-0.10.3-0.3-0.3-0.2-0.2-0.60.2-0.30.2-0.2
Time in closed arm after self-admin1.21.22.4-0.9-0.90.91.0-1.1-1.1-1.1-1.1-1.41.2-1.61.3-0.3
Time in open arm before self-admin2.22.43.7-1.5-1.51.91.5-1.5-1.5-1.6-1.6-1.11.3-1.80.91.9
Time in open arm after self-admin0.20.32.2-0.4-0.40.60.3-0.2-0.2-0.1-0.10.3-0.1-0.0-0.31.5
Bone: periosteal estimation6.613.616.04.04.0-3.8-3.93.94.03.83.83.9-3.63.5-3.3-2.0
Bone: periosteal perimeter13.222.025.45.05.0-4.9-4.94.94.94.94.94.7-4.54.6-4.1-3.3
Bone: post-yield work0.10.11.10.00.00.3-0.1-0.10.1-0.2-0.20.3-0.3-0.1-0.21.0
Progressive ratio test 1 active lever presses0.30.30.70.50.5-0.7-0.70.60.60.60.60.10.30.60.2-0.8
Progressive ratio test 1 breakpoint0.20.20.30.40.4-0.6-0.60.50.50.40.50.20.40.40.2-0.4
Progressive ratio test 1 inactive lever presses0.30.30.5-0.6-0.60.50.6-0.6-0.6-0.6-0.5-0.70.6-0.40.5-0.0
Progressive ratio test 2 active lever presses1.82.03.41.51.5-1.8-1.41.51.41.61.60.8-0.71.3-0.6-1.7
Progressive ratio test 2 breakpoint1.71.93.41.51.5-1.8-1.41.51.41.61.60.8-0.71.2-0.7-1.7
Progressive ratio test 2 inactive lever presses0.60.71.10.80.8-1.0-0.70.80.70.91.00.6-1.00.9-0.8-0.7
Incentive Sensitization - Responses1.92.03.21.51.5-1.8-1.31.51.31.51.51.0-1.31.2-1.1-1.5
Incentive Sensitization - Breakpoint2.12.13.41.61.6-1.8-1.41.51.41.61.61.1-1.41.2-1.3-1.4
Sum of active levers in priming session hrs 5-62.72.64.0-1.9-1.91.71.9-1.6-1.6-1.7-1.6-1.31.2-1.40.72.0
Progressive ratio0.91.01.7-0.9-0.91.31.0-1.0-1.0-1.0-1.1-0.71.0-1.10.61.3
Food seeking constrained by brief footshock1.41.72.8-1.4-1.41.21.5-1.5-1.4-1.6-1.7-1.10.3-1.40.01.3
Seeking ratio, punishment vs. effort0.10.10.5-0.2-0.2-0.30.1-0.1-0.1-0.2-0.2-0.3-0.40.1-0.1-0.7
Retroperitoneal fat weight13.143.050.56.96.9-7.1-6.86.66.76.66.76.5-6.86.3-5.9-5.2
Reaction time number correct0.91.31.91.31.3-1.3-1.21.11.11.01.01.1-1.41.0-1.2-0.3
Reaction time mean minus median0.50.61.10.70.7-0.9-0.50.80.71.10.90.5-0.40.9-0.6-1.0
Reaction time mean minus median AUC0.30.42.30.50.5-0.7-0.30.60.50.80.7-0.00.10.70.0-1.5
Reaction time num false alarms0.10.10.60.20.2-0.1-0.20.10.30.10.10.1-0.0-0.10.2-0.8
Reaction time num false alarms AUC0.10.11.00.20.2-0.2-0.20.30.40.20.3-0.00.1-0.00.3-1.0
Reaction time trials correct on left0.91.31.91.31.3-1.3-1.21.11.11.01.01.1-1.41.0-1.2-0.3
Reaction time trials on left1.01.42.11.31.3-1.3-1.21.21.21.11.11.2-1.51.1-1.3-0.4
Reaction time mean0.40.61.80.70.7-0.9-0.50.90.80.80.80.4-0.40.9-0.4-1.3
Reaction time mean AUC0.10.21.00.20.2-0.5-0.10.40.40.40.40.0-0.10.5-0.1-1.0
Median of all reaction times0.40.51.90.60.6-0.8-0.50.80.80.70.60.3-0.30.8-0.1-1.4
Reaction time omissions0.40.61.00.50.5-0.7-0.40.90.71.01.00.6-0.90.9-0.8-1.0
Reaction time false alarm rate0.20.20.5-0.4-0.40.50.4-0.4-0.3-0.3-0.3-0.50.7-0.60.7-0.5
Reaction time premature initiation rate0.40.52.10.50.5-0.6-0.60.60.70.70.80.20.31.00.6-1.5
Reaction time premature initiations1.11.62.71.21.2-1.3-1.31.31.31.41.50.9-0.51.7-0.2-1.6
Std. dev. reaction times1.82.63.81.61.6-1.8-1.41.71.61.81.81.3-1.31.8-1.2-2.0
Reaction time trials completed1.01.42.11.31.3-1.3-1.21.21.21.11.11.2-1.51.1-1.3-0.4
Reaction time trials AUC1.11.62.31.41.4-1.4-1.31.31.21.21.21.2-1.51.1-1.3-0.5
Run reversals in cocaine runway, females1.21.21.91.01.0-0.9-1.11.31.31.31.40.9-0.71.3-0.3-1.1
Run reversals in cocaine runway, males3.23.14.0-1.9-1.91.72.0-1.9-1.9-2.0-2.0-1.71.4-1.71.11.4
Latency to leave start box in cocaine runway1.01.12.0-1.2-1.20.81.2-1.4-1.4-1.3-1.2-1.00.8-0.80.20.5
Latency to leave start box in cocaine runway, F1.41.52.3-1.3-1.31.11.4-1.5-1.5-1.5-1.4-1.11.1-1.00.40.9
Latency to leave start box in cocaine runway, M0.20.21.20.20.2-0.7-0.30.20.20.30.3-0.0-0.30.4-0.3-1.1
Std. dev. time between licks in bursts0.10.10.2-0.3-0.30.40.3-0.3-0.2-0.3-0.40.10.2-0.30.10.5
Total sessions with >9 infusions5.66.29.12.72.7-2.6-2.82.72.62.62.71.9-1.22.7-0.6-3.0
Short access day 1 total inactive lever presses0.30.30.6-0.7-0.70.70.6-0.6-0.8-0.6-0.4-0.60.4-0.50.30.1
Short access day 10 total inactive lever presses1.01.21.61.11.1-1.1-1.11.01.01.01.01.1-1.21.3-1.1-0.8
Short access day 1 total infusions0.30.32.10.40.4-0.4-0.40.30.20.30.3-0.20.40.30.7-1.4
Short access day 10 total infusions0.20.20.80.20.2-0.3-0.40.10.20.10.1-0.30.70.00.7-0.9
Short access total infusions0.40.41.80.60.6-0.7-0.70.60.50.50.60.10.30.50.5-1.4
Short access day 1 locomotion0.40.41.80.60.6-1.0-0.60.50.40.50.60.10.10.4-0.0-1.3
Short access day 10 total locomotion0.40.41.00.70.7-1.0-0.80.70.70.60.60.3-0.30.3-0.1-0.9
Short access total locomotion1.01.14.41.01.0-1.4-1.11.00.90.91.00.10.30.60.6-2.1
One hour access (0.3 mA shock)0.50.61.00.80.8-1.0-0.70.60.60.70.70.6-1.00.7-1.0-0.7
Compulsive drug intake0.30.30.6-0.6-0.60.80.6-0.7-0.7-0.7-0.7-0.2-0.1-0.3-0.10.5
One hour access (shock baseline)1.51.82.81.51.5-1.7-1.41.41.41.41.50.9-0.81.3-0.6-1.6
Social response proportion1.61.74.21.41.4-1.4-1.41.51.41.41.50.7-0.21.40.1-2.0
Social responses5.46.98.32.72.7-2.9-2.72.82.72.82.72.5-2.42.9-2.2-2.0
Social time1.41.83.71.41.4-1.5-1.41.41.31.61.40.8-0.71.3-0.4-1.9
Soleus weight3.610.417.33.53.5-3.7-3.33.33.33.23.12.5-2.83.1-1.9-4.2
Bone: stiffness2.74.35.82.42.4-1.9-2.32.32.42.22.12.1-1.62.1-1.2-1.4
Tibialis anterior weight0.41.52.61.31.3-1.3-1.41.21.31.11.01.4-1.60.9-1.3-0.2
Time to tail flick, vehicle, before self-admin2.62.63.91.41.4-1.4-1.51.71.62.02.01.7-1.91.7-1.8-0.5
Time to tail flick, vehicle, after self-admin0.40.40.70.80.8-0.6-0.90.70.70.70.70.70.00.5-0.30.2
Time to tail flick, test, before self-admin0.70.73.30.70.7-0.5-0.60.60.80.80.80.00.60.91.0-1.8
Time to tail flick, test, after self-admin3.03.14.01.81.8-1.7-1.91.91.92.02.01.9-1.71.7-1.7-0.4
Delta time to tail flick, vehicle, before/after SA0.00.00.20.20.2-0.1-0.1-0.1-0.0-0.3-0.30.00.5-0.20.10.3
Delta time to tail flick, test, before/after SA3.53.24.91.81.8-1.5-1.91.91.81.81.82.2-2.11.5-2.20.3
Tibia length1.43.95.02.22.2-2.2-2.22.22.12.22.21.6-1.12.1-1.0-2.0
Ambulatory time before self-admin0.20.20.6-0.0-0.00.10.2-0.3-0.3-0.4-0.4-0.70.6-0.40.8-0.4
Ambulatory time after self-admin0.50.61.7-0.4-0.40.40.5-0.6-0.6-0.6-0.6-1.11.3-0.61.3-0.4
Bone: tissue strength0.30.30.6-0.6-0.60.50.6-0.6-0.7-0.6-0.6-0.50.2-0.60.00.8
Total heroin consumption0.60.71.80.80.8-1.0-0.70.80.80.80.81.0-1.00.7-1.30.1
Bone: trabecular number1.01.63.21.31.3-0.9-1.11.21.21.11.11.6-1.80.8-1.70.7
Bone: trabecular spacing0.20.30.5-0.7-0.70.50.7-0.7-0.7-0.6-0.5-0.50.2-0.30.10.3
Bone: trabecular thickness5.86.98.02.72.7-2.8-2.82.82.72.62.62.8-2.82.5-2.8-1.1
Bone: trabecular tissue density0.50.72.10.90.9-0.8-0.90.90.90.90.80.4-0.00.80.1-1.5
Water consumed over 24 hours0.00.10.3-0.0-0.00.00.00.00.0-0.0-0.0-0.30.5-0.10.5-0.4
Number of responses in last shaping day0.10.10.80.00.0-0.1-0.10.00.00.00.1-0.30.40.40.6-0.9