Hub : Genes

Babam2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_006239802.4 0.51 0.43 0.0e+00 0.24 0.25 0.25 0.25 9.9e-27 1.3e-27 2.8e-27 2.7e-27
2 Adipose intron excision ratio chr6_30463558_30467289 0.36 0.3 0.0e+00 0.22 0.22 0.22 0.22 5.7e-24 1.5e-24 4.6e-24 3.1e-24
3 RMTg isoform ratio XM_006239802.4 0.23 0.15 1.3e-05 0.11 0.12 0.1 0.09 7.0e-04 5.2e-04 1.5e-03 1.9e-03
4 Liver isoform ratio NM_199270.2 0.09 0.08 2.2e-08 0.07 0.07 0.07 0.07 1.9e-08 1.8e-08 5.5e-08 5.5e-08
5 Adipose intron excision ratio chr6_30463558_30463859 0.18 0.15 6.7e-16 0.14 0.14 0.14 0.14 5.0e-15 1.6e-15 8.0e-15 3.5e-15
6 Brain gene expression Babam2 0.04 0.03 5.5e-04 0.03 0.03 0.03 0.03 1.6e-03 7.1e-04 1.5e-03 1.3e-03
7 Liver intron excision ratio chr6_30377017_30434771 0.62 0.24 0.0e+00 0.46 0.47 0.48 0.47 2.2e-56 1.2e-58 1.3e-59 7.1e-58
8 Liver intron excision ratio chr6_30377017_30429869 0.64 0.24 0.0e+00 0.46 0.48 0.48 0.47 2.8e-57 1.3e-59 1.1e-60 7.0e-59
9 Liver intron excision ratio chr6_30463558_30467289 0.36 0.26 0.0e+00 0.25 0.25 0.25 0.25 2.7e-27 6.3e-28 4.7e-28 1.2e-27
10 PL gene expression Babam2 0.09 0.07 3.7e-09 0.08 0.08 0.05 0.08 3.7e-09 5.1e-09 7.8e-06 3.0e-09
11 Liver intron excision ratio chr6_30463932_30467289 0.24 0.17 0.0e+00 0.19 0.19 0.19 0.19 5.1e-21 5.3e-21 4.8e-21 6.2e-21
12 Adipose isoform ratio XM_006239802.4 0.18 0.15 1.3e-15 0.13 0.14 0.13 0.14 1.1e-14 4.5e-15 1.1e-14 4.0e-15
13 Liver intron excision ratio chr6_30463558_30463859 0.28 0.22 0.0e+00 0.2 0.2 0.21 0.2 1.8e-21 2.2e-22 2.0e-22 4.2e-22
14 pVTA gene expression Babam2 0.05 0.06 2.0e-03 0.03 0.02 0.02 0.03 1.2e-03 8.6e-03 7.0e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density4.99.010.13.0-3.03.0-3.03.03.03.1-3.13.12.9-2.92.9-3.2-2.9
Area under the delay curve0.60.91.70.7-0.70.8-0.80.80.90.9-0.90.91.3-1.11.1-1.0-0.7
BMI with tail0.20.70.8-0.90.9-0.90.9-0.9-0.9-0.80.8-0.8-0.90.8-0.70.80.8
BMI without tail0.42.12.6-1.51.4-1.41.4-1.4-1.4-1.41.4-1.4-1.61.5-1.31.51.6
Body weight1.98.39.0-3.03.0-3.02.9-2.9-2.9-2.92.9-2.9-2.92.8-2.72.82.7
Weight adjusted by age0.00.00.00.00.0-0.00.0-0.0-0.1-0.00.0-0.0-0.20.2-0.20.0-0.1
Bone surface2.55.05.82.3-2.22.2-2.22.22.22.4-2.42.32.1-2.12.1-2.4-2.1
Bone volume2.65.26.22.3-2.32.3-2.22.22.22.4-2.42.42.1-2.12.1-2.5-2.2
Breakpoint value in progressive ratio session0.71.31.81.1-1.01.0-1.01.01.01.3-1.31.30.9-1.21.2-1.4-1.1
Number of licking bursts0.10.20.40.4-0.40.4-0.40.40.50.5-0.50.50.6-0.50.5-0.6-0.4
Context. condit. distance diff. score0.00.00.00.0-0.00.0-0.00.00.0-0.00.0-0.00.00.00.00.10.1
Locomotion velocity, session 10.10.10.5-0.10.2-0.20.2-0.2-0.2-0.10.1-0.2-0.40.3-0.30.30.7
Locomotion distance, session 11.92.52.71.6-1.61.6-1.61.61.61.6-1.61.61.5-1.61.6-1.5-1.4
Locomotion velocity, session 20.20.20.3-0.40.4-0.40.4-0.4-0.4-0.50.5-0.5-0.40.4-0.40.50.5
Locomotion distance, session 20.00.00.10.0-0.0-0.00.0-0.0-0.0-0.10.1-0.1-0.20.1-0.10.20.3
Locomotion velocity, session 30.50.50.70.8-0.80.8-0.80.70.70.8-0.80.80.7-0.70.7-0.7-0.4
Locomotion distance, session 30.70.80.90.9-0.90.9-0.90.90.90.9-0.90.90.9-0.90.9-0.8-0.9
Stereotopy head waving bouts, day 31.61.92.01.4-1.41.4-1.41.41.41.4-1.41.41.3-1.41.3-1.4-1.3
Stereotopy head waving duration, day 30.10.10.10.3-0.30.3-0.30.30.30.3-0.30.30.2-0.30.2-0.3-0.2
Locomotion velocity, session 70.91.01.51.0-1.01.0-1.01.01.01.2-1.21.10.8-0.90.8-1.2-0.8
Locomotion distance, session 70.00.00.10.1-0.10.1-0.10.10.10.3-0.30.2-0.10.1-0.1-0.30.1
Stereotopy head waving bouts, day 70.00.00.10.2-0.20.1-0.20.20.20.0-0.00.10.2-0.20.20.0-0.3
Stereotopy head waving duration, day 70.20.30.50.6-0.60.6-0.60.60.60.4-0.40.40.6-0.60.6-0.3-0.7
Locomotion velocity, session 80.00.00.10.2-0.20.2-0.20.20.20.2-0.20.1-0.10.0-0.0-0.00.3
Locomotion distance, session 80.20.30.40.7-0.60.6-0.60.60.60.6-0.60.60.5-0.60.6-0.5-0.3
Degree of sensitization distance0.80.81.1-0.90.9-0.90.9-0.9-1.0-0.80.8-0.8-1.01.0-1.00.71.1
Degree of sensitization stereotypy0.10.10.3-0.40.4-0.40.4-0.4-0.3-0.50.5-0.5-0.30.3-0.30.50.1
Conditioned locomotion3.13.74.11.9-1.91.9-1.91.91.91.8-1.91.92.0-1.91.9-1.8-2.0
Cocaine response after cond. corrected1.01.41.71.1-1.11.1-1.11.21.21.2-1.21.21.3-1.31.3-1.2-1.1
Cocaine response after cond. not corrected2.02.83.11.6-1.61.6-1.61.61.61.7-1.71.71.7-1.81.8-1.7-1.6
Cocaine response before conditioning1.01.21.41.2-1.21.2-1.21.21.11.2-1.21.11.0-1.01.0-1.1-1.0
Saline control response0.40.50.60.8-0.80.8-0.80.80.80.7-0.70.70.7-0.70.7-0.6-0.7
Bone: connectivity density4.97.98.72.8-2.82.8-2.82.82.82.9-2.92.92.7-2.82.7-2.9-2.7
Bone: cortical apparent density0.61.01.40.9-1.01.0-1.01.01.01.0-1.01.01.1-1.01.0-1.0-1.2
Bone: cortical area0.81.42.11.1-1.11.1-1.11.11.11.3-1.31.31.1-1.01.0-1.5-1.2
Bone: cortical porosity0.80.91.11.0-1.01.0-1.01.01.00.8-0.80.81.0-0.90.9-0.7-0.7
Bone: cortical porosity0.91.01.21.0-1.11.1-1.11.11.11.0-1.01.01.0-1.01.0-0.9-0.8
Bone: cortical thickness0.00.00.10.2-0.20.1-0.10.10.10.2-0.20.20.2-0.10.1-0.3-0.2
Bone: cortical thickness1.51.92.01.4-1.41.4-1.41.41.41.4-1.41.41.4-1.31.3-1.4-1.2
Bone: cortical tissue density0.50.71.00.8-0.80.8-0.80.80.80.8-0.80.81.0-0.90.9-0.9-1.0
Condit. Reinf. active minus inactive responses0.30.40.5-0.70.7-0.70.7-0.7-0.7-0.50.5-0.5-0.60.6-0.60.40.5
Condit. Reinf. active-inactive response ratio0.40.40.6-0.80.8-0.80.8-0.8-0.7-0.60.6-0.6-0.60.6-0.60.40.5
Condit. Reinf. active responses0.40.50.80.6-0.60.6-0.60.60.60.8-0.70.80.7-0.70.7-0.9-0.7
Condit. Reinf. inactive responses1.82.32.41.6-1.51.5-1.51.51.51.5-1.51.61.5-1.61.5-1.5-1.4
Incentive salience index mean0.10.10.40.3-0.20.2-0.30.30.30.5-0.50.50.3-0.30.3-0.6-0.4
Condit. Reinf. lever presses1.01.41.81.2-1.11.1-1.11.11.11.3-1.31.31.2-1.21.2-1.3-1.2
Condit. Reinf. active minus inactive responses3.04.65.12.2-2.22.2-2.22.22.22.1-2.12.12.1-2.22.2-2.1-2.3
Condit. Reinf. active-inactive response ratio0.71.11.31.1-1.11.0-1.11.11.10.9-1.01.01.0-1.11.1-0.9-1.1
Condit. Reinf. active responses3.04.44.92.1-2.12.0-2.02.12.02.1-2.12.12.0-2.02.1-2.2-2.2
Condit. Reinf. inactive responses1.62.33.41.4-1.41.4-1.41.41.41.7-1.71.71.4-1.41.4-1.9-1.5
Condit. Reinf. lever presses2.13.03.31.7-1.71.7-1.71.71.71.7-1.71.71.7-1.81.8-1.8-1.8
Condit. Reinf. lever reinforcers received2.73.84.32.0-1.91.9-1.91.91.92.0-2.02.01.8-1.91.9-2.1-2.1
Conditioned reinforcement - actives0.10.30.50.6-0.70.7-0.70.70.60.4-0.40.40.3-0.40.4-0.2-0.6
Conditioned reinforcement - inactives1.23.33.92.0-1.91.9-1.91.91.91.8-1.81.81.7-1.71.7-1.7-1.8
Conditioned locomotion0.40.51.4-0.60.5-0.50.5-0.5-0.6-0.60.6-0.7-0.91.0-0.90.81.2
Patch foraging indifference point 0 sec0.20.60.7-0.80.8-0.80.8-0.8-0.8-0.60.6-0.7-0.70.8-0.80.40.6
Patch foraging indifference point AUC0.61.41.81.3-1.31.3-1.31.31.31.2-1.21.11.2-1.11.1-1.0-1.0
Delay disc. indifference point, 0s delay1.71.92.3-1.51.5-1.41.4-1.4-1.4-1.51.5-1.4-1.01.2-1.21.41.4
Delay disc. indifference point, 16s delay0.60.81.40.7-0.70.8-0.80.80.80.9-0.91.01.2-1.11.1-1.1-0.8
Delay disc. indifference point, 2s delay0.10.10.5-0.30.3-0.30.3-0.3-0.3-0.30.3-0.3-0.20.3-0.30.40.7
Delay disc. indifference point, 24s delay2.54.05.71.7-1.71.7-1.81.81.91.9-1.92.02.4-2.32.3-2.2-2.2
Delay disc. indifference point, 4s delay0.00.00.10.2-0.20.2-0.20.20.20.1-0.10.10.3-0.20.2-0.1-0.3
Delay disc. indifference point, 8s delay0.30.61.30.5-0.50.6-0.60.60.70.7-0.70.81.2-0.91.0-0.8-0.6
Indifference point function ln k0.00.00.0-0.10.1-0.00.1-0.1-0.1-0.10.1-0.1-0.10.1-0.10.20.1
Indifference point function log k0.00.00.0-0.10.1-0.00.1-0.1-0.1-0.10.1-0.1-0.10.1-0.10.20.1
Patch foraging total patch changes 0 sec0.20.50.6-0.70.8-0.80.8-0.8-0.8-0.50.5-0.6-0.70.8-0.80.40.6
Patch foraging total patch changes 12 sec0.91.21.4-1.21.1-1.11.1-1.1-1.1-1.11.1-1.1-1.01.2-1.21.01.1
Patch foraging total patch changes 18 sec0.10.20.3-0.40.4-0.40.4-0.4-0.4-0.40.4-0.4-0.50.5-0.50.40.5
Patch foraging total patch changes 24 sec0.51.82.1-1.31.3-1.31.3-1.3-1.3-1.31.3-1.3-1.31.4-1.41.31.4
Patch foraging total patch changes 6 sec0.10.10.2-0.40.4-0.40.4-0.4-0.4-0.40.4-0.4-0.30.4-0.50.30.2
Patch foraging time to switch 0 sec0.00.10.20.0-0.00.1-0.10.10.10.2-0.20.30.3-0.30.3-0.4-0.4
Patch foraging water rate 0 sec0.00.10.2-0.10.1-0.20.2-0.2-0.2-0.30.3-0.3-0.40.3-0.40.40.4
Patch foraging water rate 12 sec0.62.52.7-1.61.5-1.61.6-1.6-1.6-1.61.6-1.6-1.61.5-1.61.61.4
Patch foraging water rate 18 sec0.41.01.1-1.01.0-1.01.0-1.0-1.0-1.11.1-1.1-0.81.0-1.01.11.0
Patch foraging water rate 24 sec2.02.93.4-1.81.7-1.81.8-1.7-1.7-1.71.7-1.7-1.71.7-1.61.61.5
Patch foraging water rate 6 sec1.42.02.3-1.41.4-1.41.4-1.4-1.4-1.51.5-1.5-1.51.4-1.41.51.2
Seeking ratio, delayed vs. immediate footshock0.40.61.9-0.60.5-0.50.5-0.5-0.6-0.70.7-0.8-0.70.8-0.71.01.4
Distance traveled before self-admin0.00.00.1-0.0-0.00.0-0.00.10.1-0.10.1-0.00.0-0.10.10.0-0.4
Distance traveled after self-admin1.11.92.2-1.41.4-1.41.4-1.4-1.4-1.41.4-1.4-1.51.3-1.41.31.1
Extensor digitorum longus weight4.718.619.24.3-4.34.3-4.34.34.34.4-4.44.44.3-4.34.3-4.4-4.2
Bone: elastic displacement0.60.70.90.9-0.90.9-0.90.90.90.7-0.80.80.9-0.90.9-0.7-0.9
Bone: elastic work1.21.52.11.2-1.21.2-1.21.21.21.2-1.21.21.2-1.21.2-1.3-1.4
Bone: endosteal estimation0.61.62.21.2-1.21.2-1.21.21.21.4-1.41.41.1-1.11.1-1.5-1.2
Bone: endosteal perimeter0.30.81.30.8-0.80.8-0.80.80.81.0-1.01.00.8-0.80.8-1.1-1.0
Epididymis fat weight11.155.858.5-7.77.6-7.67.6-7.6-7.6-7.57.5-7.4-7.47.4-7.47.27.1
Delta time in closed arm before/after self-admin0.00.00.20.2-0.10.1-0.10.10.10.2-0.20.20.3-0.20.1-0.3-0.4
Delta time in open arm before/after self-admin0.10.20.30.3-0.40.4-0.40.40.40.5-0.50.40.4-0.40.5-0.5-0.3
Diff in mean of infusions in LGA sessions0.00.00.1-0.1-0.10.0-0.00.00.00.0-0.0-0.0-0.30.1-0.0-0.00.1
Delay discount exponential model param1.11.52.6-1.01.0-1.11.1-1.1-1.2-1.21.2-1.3-1.61.4-1.41.31.0
Extinction: sum of active levers before priming0.50.71.10.8-0.80.8-0.80.80.80.9-0.90.91.0-1.01.0-0.9-0.5
Active lever presses in extinction session 60.10.10.20.4-0.40.4-0.40.40.30.4-0.40.40.1-0.20.2-0.4-0.1
Bone: final force0.20.30.60.4-0.40.4-0.40.40.40.7-0.70.60.4-0.40.4-0.8-0.4
Bone: final moment0.20.40.80.5-0.50.5-0.50.50.50.8-0.80.70.5-0.50.5-0.9-0.4
Food consumed during 24 hour testing period0.10.20.20.5-0.50.5-0.50.50.50.5-0.50.40.5-0.40.4-0.4-0.4
Glucose0.30.50.7-0.70.7-0.70.7-0.7-0.7-0.70.7-0.7-0.80.8-0.80.70.7
Heart weight3.04.85.4-2.12.2-2.22.2-2.2-2.2-2.22.2-2.2-2.32.3-2.32.12.2
Delay discount hyperbolic model param0.71.01.8-0.80.8-0.90.9-0.9-0.9-1.01.0-1.0-1.31.1-1.11.10.7
Intermittent access intake day 1-15 change0.00.10.3-0.30.2-0.20.2-0.2-0.3-0.30.3-0.4-0.50.5-0.50.40.5
Intermittent access intake escalation0.10.30.5-0.50.4-0.40.4-0.4-0.5-0.50.5-0.6-0.70.6-0.70.60.7
Intermittent access intake escalation 20.20.31.2-0.40.3-0.40.4-0.4-0.5-0.40.4-0.5-0.80.7-0.80.61.1
Intermitt. access day 1 inactive lever presses0.10.91.31.1-1.01.0-1.01.00.90.9-0.90.90.7-0.80.7-0.9-0.9
Intermitt. access day 15 inactive lever presses0.84.66.22.5-2.42.4-2.32.32.22.1-2.12.01.9-1.81.8-1.8-2.0
Intermitt. access escalation Index0.20.50.7-0.70.6-0.60.6-0.7-0.7-0.60.6-0.7-0.70.9-0.80.70.7
Intermittent access day 1 total infusions1.44.14.82.2-2.12.1-2.12.12.12.0-2.02.02.0-1.91.9-1.9-2.0
Intermittent access day 15 total infusions0.41.01.31.1-1.11.1-1.11.11.11.0-1.01.00.9-0.90.8-0.9-0.8
Intermittent access terminal intake (last 3 days)0.91.62.01.4-1.41.4-1.41.31.31.3-1.31.31.1-1.11.1-1.2-1.1
Intermittent access total infusions1.31.51.81.3-1.31.3-1.31.31.31.2-1.21.21.2-1.21.2-1.1-1.3
Intermittent access day 1 locomotion1.22.22.41.5-1.51.5-1.51.51.51.5-1.51.51.5-1.51.5-1.5-1.4
Intermittent access day 15 total locomotion0.00.00.10.2-0.30.2-0.20.20.20.2-0.10.10.0-0.10.0-0.00.1
Intermittent access total locomotion0.00.00.10.2-0.30.3-0.30.30.30.2-0.20.20.2-0.20.2-0.10.0
Intermittent access standard deviation0.20.91.11.0-1.01.0-1.01.01.01.0-1.01.00.8-0.90.8-0.9-0.8
Left kidney weight0.00.00.0-0.10.1-0.20.1-0.1-0.1-0.10.1-0.1-0.20.0-0.10.00.1
Right kidney weight0.10.81.1-1.01.1-1.01.0-1.0-1.0-1.00.9-0.9-0.70.7-0.70.80.8
Cocaine induced anxiety0.10.20.20.4-0.40.4-0.40.40.40.5-0.50.40.2-0.30.2-0.5-0.2
Post-drug Anxiety1.11.21.4-1.11.1-1.11.1-1.1-1.1-1.21.2-1.2-1.11.1-1.11.10.6
Baseline Anxiety1.83.13.7-1.81.8-1.81.8-1.8-1.8-1.91.9-1.9-1.61.6-1.61.81.2
Tail length0.42.32.7-1.51.4-1.51.5-1.5-1.5-1.51.5-1.5-1.71.5-1.51.51.4
Length with tail1.98.69.1-3.03.0-3.03.0-3.0-3.0-3.03.0-3.0-2.92.9-2.92.92.7
Length without tail0.41.92.1-1.41.5-1.41.4-1.4-1.4-1.41.4-1.4-1.21.4-1.41.31.2
Times rat made contact with spout2.73.13.41.7-1.71.7-1.71.71.71.8-1.81.81.8-1.81.8-1.9-1.8
Lifetime Intake1.21.51.91.4-1.31.3-1.31.31.31.2-1.21.21.1-1.21.1-1.1-1.2
Liver weight, left3.56.16.5-2.42.5-2.52.5-2.5-2.5-2.42.4-2.4-2.62.5-2.52.32.4
Liver weight, right10.017.518.0-4.24.2-4.24.2-4.2-4.2-4.14.1-4.1-4.24.2-4.24.04.2
Locomotor activity0.00.00.1-0.30.3-0.30.3-0.3-0.2-0.20.2-0.10.00.1-0.00.00.2
Locomotor testing distance0.20.60.80.6-0.60.7-0.70.70.70.8-0.80.80.9-0.80.9-0.8-0.6
Locomotor testing rearing0.20.81.00.8-0.90.9-0.90.90.91.0-1.01.00.8-0.90.9-1.0-0.8
Locomotion in novel chamber0.40.50.7-0.80.8-0.80.8-0.8-0.8-0.60.6-0.7-0.80.8-0.80.50.6
Locomotion in novel chamber post-restriction1.23.84.6-2.22.1-2.12.1-2.0-2.0-1.91.9-1.9-1.91.8-1.81.81.8
Fecal boli incidents, locomotor time 10.10.40.80.5-0.60.7-0.70.70.70.4-0.40.50.9-0.60.7-0.4-0.8
Change in fecal boli incidents, locomotor task3.74.04.3-1.92.1-2.12.1-2.1-2.1-2.02.0-1.9-2.01.9-2.01.91.9
Time >=10cm from walls, locomotor time 10.00.00.20.10.00.0-0.00.00.1-0.00.00.10.5-0.30.3-0.1-0.3
Bouts of movement, locomotor time 12.22.83.51.5-1.61.7-1.71.71.71.6-1.61.61.9-1.71.8-1.6-1.7
Total resting periods, locomotor time 12.52.93.61.6-1.71.7-1.71.71.71.6-1.61.61.9-1.71.8-1.7-1.8
Rest time, locomotor task time 10.10.10.2-0.30.3-0.30.3-0.3-0.3-0.30.3-0.3-0.20.3-0.30.30.4
Distance moved, locomotor task time 10.30.81.0-0.91.0-1.01.0-1.0-1.0-0.80.8-0.8-0.90.9-1.00.70.8
Vertical activity count, locomotor time 10.00.30.4-0.40.6-0.60.6-0.6-0.6-0.50.5-0.5-0.60.4-0.50.40.2
Time >=10cm from walls, locomotor time 20.00.10.10.3-0.30.3-0.30.30.30.3-0.30.20.3-0.20.2-0.20.1
Bouts of movement, locomotor time 20.00.00.1-0.20.1-0.10.1-0.1-0.1-0.30.3-0.30.00.1-0.00.30.0
Total resting periods, locomotor time 20.00.00.10.1-0.10.2-0.10.10.1-0.00.0-0.00.2-0.10.10.1-0.2
Rest time, locomotor task time 21.11.82.11.3-1.41.4-1.41.41.41.3-1.31.31.4-1.41.4-1.3-1.1
Distance moved, locomotor task time 21.11.41.8-1.11.2-1.31.2-1.3-1.3-1.01.0-1.1-1.31.3-1.30.91.1
Vertical activity count, locomotor time 20.41.01.3-0.91.0-1.01.0-1.0-1.0-1.01.0-1.0-1.11.1-1.10.90.7
Light reinforcement 11.88.19.32.8-2.82.8-2.82.82.82.9-2.92.92.9-2.72.7-3.0-2.9
Light reinforcement 22.14.85.22.3-2.22.3-2.22.22.22.2-2.22.22.2-2.12.1-2.2-2.1
Bone: marrow area0.61.62.21.2-1.21.2-1.21.21.21.4-1.41.41.1-1.11.1-1.5-1.2
Bone: maximum diameter1.42.73.81.6-1.61.6-1.61.61.61.8-1.81.81.5-1.51.5-1.9-1.7
Bone: maximum force0.20.30.70.5-0.50.5-0.50.50.50.7-0.70.70.5-0.50.5-0.9-0.5
Bone: maximum moment0.30.51.00.7-0.60.6-0.60.60.60.9-0.90.80.6-0.60.6-1.0-0.6
Mean time between licks in bursts0.63.63.8-1.91.9-1.91.9-1.9-1.9-1.91.9-1.9-1.91.9-1.91.91.8
Mean num. licks in bursts0.00.10.30.4-0.40.3-0.30.30.30.3-0.30.30.3-0.30.3-0.3-0.5
Cd content in liver0.00.00.10.1-0.10.1-0.10.10.10.1-0.10.10.2-0.20.2-0.1-0.2
Co content in liver6.77.98.12.8-2.82.8-2.82.82.82.8-2.82.82.8-2.82.8-2.8-2.8
Cu content in liver0.10.10.10.3-0.30.3-0.30.30.30.3-0.30.30.4-0.30.4-0.3-0.2
Fe content in liver0.50.60.70.8-0.80.8-0.80.80.80.8-0.80.80.8-0.70.7-0.8-0.7
K content in liver0.50.40.60.7-0.70.7-0.70.70.70.8-0.80.70.5-0.60.6-0.7-0.4
Mg content in liver0.60.60.80.8-0.80.8-0.80.80.80.9-0.90.90.7-0.80.7-0.9-0.6
Mn content in liver0.00.00.10.2-0.20.2-0.20.20.20.3-0.30.20.1-0.10.2-0.20.1
Na content in liver0.30.40.40.6-0.70.7-0.70.60.60.6-0.60.60.6-0.50.5-0.6-0.4
Rb content in liver0.00.00.10.2-0.10.2-0.20.20.20.2-0.20.20.2-0.20.2-0.2-0.2
Se content in liver0.30.40.5-0.60.5-0.50.6-0.6-0.6-0.50.5-0.6-0.70.7-0.70.50.7
Sr content in liver0.10.10.1-0.30.3-0.30.3-0.3-0.3-0.20.2-0.2-0.20.2-0.20.20.3
Zn content in liver0.80.91.0-0.91.0-1.01.0-1.0-1.0-0.90.9-0.9-1.01.0-1.00.90.9
Bone: minimum diameter0.00.00.1-0.20.2-0.20.2-0.2-0.20.1-0.10.0-0.30.3-0.2-0.30.0
Time in familiar zone, hab. session 10.70.70.9-0.90.9-0.80.9-0.9-0.9-0.80.9-0.9-0.80.9-1.00.80.7
Time in novel zone, hab. session 10.70.70.9-0.90.9-0.90.9-0.9-0.9-0.80.8-0.8-0.90.8-0.80.91.0
Total zone transitions, hab. session 10.10.20.20.4-0.40.4-0.40.40.40.5-0.50.50.3-0.40.4-0.5-0.4
Total locomotion distance, hab. session 10.10.20.20.4-0.40.4-0.40.40.40.4-0.40.40.3-0.30.4-0.4-0.4
Locomotion velocity, hab. session 11.11.51.61.2-1.31.3-1.21.31.21.3-1.31.31.1-1.21.2-1.3-1.2
Time in familiar zone, hab. session 20.00.00.10.0-0.0-0.00.0-0.0-0.00.1-0.10.1-0.20.1-0.1-0.10.3
Time in novel zone, hab. session 20.30.40.5-0.70.7-0.60.6-0.6-0.6-0.70.7-0.6-0.40.5-0.50.60.4
Total zone transitions, hab. session 20.20.20.30.5-0.50.5-0.50.50.50.5-0.50.50.4-0.50.5-0.5-0.4
Total locomotion distance, hab. session 20.20.30.30.6-0.60.6-0.60.60.60.5-0.50.50.5-0.60.6-0.4-0.5
Locomotion velocity, hab. session 20.50.60.70.8-0.80.8-0.80.80.80.7-0.70.70.8-0.80.9-0.7-0.8
Novel to familiar place preference ratio0.60.71.0-0.90.9-0.90.9-0.9-0.9-1.01.0-0.9-0.60.7-0.80.90.5
Novelty place preference1.01.31.7-1.21.2-1.21.2-1.2-1.1-1.31.3-1.2-0.91.0-1.11.20.8
Time in novel zone, NPP test1.41.62.0-1.31.3-1.31.3-1.3-1.3-1.41.4-1.4-1.11.2-1.21.31.0
Total zone transitions, NPP test1.52.22.41.5-1.51.5-1.51.51.51.5-1.51.51.4-1.51.5-1.4-1.2
Total locomotion distance, NPP test1.92.62.81.7-1.71.7-1.71.71.71.6-1.61.61.5-1.61.6-1.5-1.6
Locomotion velocity, NPP test3.44.85.02.2-2.22.2-2.22.22.22.1-2.12.22.1-2.22.2-2.1-2.2
Intraocular pressure3.65.86.7-2.52.6-2.62.6-2.6-2.5-2.42.4-2.3-2.32.3-2.32.22.2
Delta distance traveled before/after self-admin2.02.22.7-1.41.5-1.51.5-1.5-1.5-1.41.4-1.4-1.61.6-1.61.41.6
Delta ambulatory time before/after self-admin0.10.30.6-0.40.5-0.50.5-0.5-0.5-0.30.3-0.4-0.60.6-0.60.40.8
Parametrial fat weight10.624.925.5-5.05.0-5.05.0-5.0-5.0-5.05.0-5.0-4.95.0-5.04.94.9
Pavlov. Cond. lever latency1.92.42.6-1.61.6-1.61.6-1.6-1.6-1.61.6-1.6-1.61.5-1.51.61.4
Pavlov. Cond. magazine entry latency0.10.10.10.4-0.30.3-0.30.30.30.3-0.30.30.3-0.30.3-0.2-0.2
Pavlov. Cond. change in total contacts0.10.10.10.3-0.20.3-0.20.20.30.2-0.20.30.3-0.20.2-0.3-0.2
Pavlov. Cond. index score0.81.01.21.1-1.01.0-1.01.01.01.0-1.01.01.0-1.00.9-1.0-0.9
Pavlov. Cond. latency score0.81.01.11.1-1.01.0-1.01.01.01.0-1.01.01.0-0.90.9-1.0-0.8
Pavlov. Cond. lever contacts1.31.61.71.3-1.31.3-1.31.31.31.3-1.31.31.3-1.21.2-1.3-1.2
Pavlov. Cond. magazine entry number0.50.60.7-0.80.8-0.80.8-0.8-0.8-0.80.8-0.8-0.70.7-0.70.70.6
Pavlov. Cond. intertrial magazine entries1.61.92.51.3-1.31.3-1.31.31.31.5-1.51.51.4-1.41.4-1.6-1.3
Pavlov. Cond. lever-magazine prob. diff.1.62.02.21.5-1.41.4-1.41.41.41.4-1.41.41.5-1.41.4-1.4-1.4
Pavlov. Cond. response bias1.41.71.91.4-1.31.3-1.31.31.31.3-1.31.31.3-1.31.3-1.3-1.3
Pavlov. Cond. lever latency1.52.12.5-1.41.4-1.41.4-1.4-1.4-1.41.4-1.4-1.41.4-1.41.41.6
Pavlov. Cond. magazine entry latency0.10.10.10.4-0.40.4-0.40.40.30.4-0.40.30.2-0.20.2-0.3-0.3
Pavlov. Cond. change in total contacts0.41.01.61.0-1.01.0-1.01.01.00.9-0.90.91.0-1.11.1-0.9-1.3
Pavlov. Cond. index score0.81.31.61.1-1.21.2-1.21.11.11.1-1.11.11.1-1.11.1-1.1-1.2
Pavlov. Cond. latency score0.71.21.41.1-1.11.1-1.11.11.11.0-1.01.01.0-1.01.0-1.0-1.2
Pavlov. Cond. lever contacts1.11.62.11.2-1.21.2-1.21.21.21.2-1.21.21.2-1.31.3-1.3-1.5
Pavlov. Cond. magazine entry number0.10.10.2-0.30.4-0.40.4-0.4-0.3-0.40.4-0.4-0.20.2-0.30.40.4
Pavlov. Cond. intertrial magazine entries2.04.44.9-2.22.2-2.22.2-2.2-2.2-2.02.0-2.0-2.12.0-2.01.92.0
Pavlov. Cond. lever-magazine prob. diff.0.50.81.00.9-0.90.9-0.90.90.90.9-0.90.90.8-0.80.8-0.9-1.0
Pavlov. Cond. response bias1.82.43.01.5-1.51.5-1.51.51.51.5-1.51.61.5-1.51.5-1.6-1.7
Time in closed arm before self-admin0.81.42.2-1.21.1-1.21.2-1.2-1.2-1.01.1-1.1-1.41.3-1.21.11.5
Time in closed arm after self-admin1.51.82.2-1.41.3-1.41.4-1.3-1.4-1.21.2-1.2-1.31.4-1.41.21.5
Time in open arm before self-admin0.30.30.80.5-0.50.5-0.50.50.50.4-0.40.50.6-0.70.6-0.5-0.9
Time in open arm after self-admin1.82.02.31.4-1.41.4-1.41.41.41.4-1.41.41.5-1.41.5-1.4-1.4
Bone: periosteal estimation1.12.73.81.6-1.61.6-1.61.61.51.8-1.81.81.5-1.51.5-2.0-1.7
Bone: periosteal perimeter0.61.21.91.0-1.01.0-1.01.01.01.2-1.21.21.0-1.01.0-1.4-1.2
Bone: post-yield work0.71.21.41.0-1.11.1-1.11.11.11.2-1.11.11.1-1.01.0-1.2-1.0
Progressive ratio test 1 active lever presses0.61.11.31.1-1.11.1-1.11.11.11.1-1.01.11.0-1.01.0-1.0-1.0
Progressive ratio test 1 breakpoint0.71.21.41.2-1.11.1-1.11.11.11.1-1.11.11.1-1.11.1-1.1-1.1
Progressive ratio test 1 inactive lever presses0.71.92.61.6-1.61.6-1.51.51.51.2-1.21.21.2-1.31.2-1.0-1.4
Progressive ratio test 2 active lever presses0.00.00.00.1-0.10.1-0.10.00.00.0-0.00.0-0.20.1-0.1-0.0-0.1
Progressive ratio test 2 breakpoint0.00.00.10.00.0-0.00.0-0.0-0.1-0.00.0-0.1-0.20.2-0.20.00.0
Progressive ratio test 2 inactive lever presses0.10.40.70.8-0.80.8-0.80.70.70.6-0.60.60.3-0.40.3-0.5-0.6
Incentive Sensitization - Responses0.00.00.1-0.0-0.00.0-0.00.0-0.00.0-0.0-0.0-0.30.1-0.2-0.1-0.1
Incentive Sensitization - Breakpoint0.00.10.2-0.20.1-0.10.1-0.2-0.2-0.10.1-0.2-0.50.3-0.40.10.1
Sum of active levers in priming session hrs 5-61.21.11.41.0-1.01.0-1.01.01.01.1-1.11.21.0-1.11.0-1.2-0.9
Progressive ratio0.10.41.0-0.30.5-0.60.6-0.6-0.6-0.60.6-0.6-1.00.8-0.90.70.6
Food seeking constrained by brief footshock1.51.92.61.6-1.61.6-1.61.61.51.2-1.21.21.4-1.31.2-1.0-1.2
Seeking ratio, punishment vs. effort0.40.91.60.8-0.91.0-1.01.01.00.8-0.80.81.3-1.11.1-0.8-1.0
Retroperitoneal fat weight20.893.096.1-9.79.8-9.89.8-9.8-9.8-9.69.6-9.6-9.59.7-9.79.39.4
Reaction time number correct0.31.01.11.0-1.01.0-1.01.01.01.0-1.01.00.9-1.01.1-1.0-1.0
Reaction time mean minus median0.00.10.2-0.20.2-0.10.1-0.2-0.1-0.30.3-0.3-0.00.2-0.20.40.3
Reaction time mean minus median AUC0.00.10.3-0.30.3-0.30.3-0.3-0.3-0.40.4-0.4-0.10.3-0.30.50.4
Reaction time num false alarms0.10.20.60.4-0.30.3-0.30.40.40.4-0.40.50.6-0.50.5-0.6-0.7
Reaction time num false alarms AUC0.20.40.80.5-0.40.5-0.50.50.50.6-0.60.60.7-0.60.6-0.8-0.9
Reaction time trials correct on left0.31.01.11.0-1.01.0-1.01.01.01.0-1.01.00.9-1.01.1-1.0-1.0
Reaction time trials on left0.31.11.21.1-1.11.0-1.01.11.01.0-1.11.00.9-1.01.1-1.0-1.0
Reaction time mean0.81.81.8-1.31.3-1.31.3-1.3-1.3-1.31.3-1.3-1.31.3-1.31.31.4
Reaction time mean AUC0.61.41.5-1.21.2-1.21.2-1.2-1.2-1.21.2-1.2-1.21.2-1.21.11.2
Median of all reaction times1.11.82.0-1.31.4-1.41.4-1.4-1.4-1.31.3-1.3-1.41.4-1.41.21.3
Reaction time omissions0.00.10.10.2-0.30.3-0.30.30.30.3-0.30.30.2-0.20.3-0.3-0.2
Reaction time false alarm rate0.00.00.1-0.00.1-0.10.1-0.1-0.00.1-0.10.10.2-0.10.1-0.3-0.3
Reaction time premature initiation rate0.20.20.5-0.50.5-0.40.4-0.4-0.4-0.70.6-0.6-0.10.4-0.40.70.5
Reaction time premature initiations0.00.00.10.1-0.10.2-0.20.20.2-0.10.1-0.00.4-0.20.20.2-0.0
Std. dev. reaction times0.20.70.8-0.80.8-0.80.8-0.8-0.8-0.80.8-0.9-0.80.9-0.80.90.9
Reaction time trials completed0.31.11.21.1-1.11.0-1.01.11.01.0-1.11.00.9-1.01.1-1.0-1.0
Reaction time trials AUC0.41.31.41.2-1.21.1-1.11.11.11.2-1.21.21.0-1.11.2-1.1-1.1
Run reversals in cocaine runway, females0.00.00.1-0.10.1-0.10.1-0.1-0.0-0.30.3-0.30.1-0.00.10.3-0.3
Run reversals in cocaine runway, males0.30.31.10.5-0.40.4-0.50.50.50.3-0.30.40.7-0.70.7-0.4-1.0
Latency to leave start box in cocaine runway0.20.30.40.5-0.60.6-0.60.60.60.6-0.60.60.5-0.50.5-0.5-0.1
Latency to leave start box in cocaine runway, F0.30.40.60.5-0.60.6-0.60.60.60.7-0.70.70.6-0.60.6-0.8-0.7
Latency to leave start box in cocaine runway, M0.20.21.2-0.20.1-0.20.2-0.2-0.2-0.30.3-0.4-0.40.4-0.40.61.1
Std. dev. time between licks in bursts0.00.10.1-0.30.2-0.30.3-0.3-0.3-0.20.2-0.2-0.40.3-0.30.20.3
Total sessions with >9 infusions0.10.10.20.5-0.40.4-0.40.40.40.4-0.40.30.4-0.30.3-0.3-0.3
Short access day 1 total inactive lever presses3.57.08.42.9-2.92.9-2.82.82.82.5-2.52.52.5-2.52.5-2.2-2.6
Short access day 10 total inactive lever presses0.63.94.62.1-2.02.0-2.02.02.01.9-1.91.91.9-1.91.9-1.8-2.0
Short access day 1 total infusions1.01.92.51.5-1.61.5-1.51.51.51.3-1.31.31.3-1.11.1-1.1-1.3
Short access day 10 total infusions1.11.92.21.5-1.41.4-1.41.41.41.3-1.31.31.4-1.41.3-1.2-1.4
Short access total infusions0.20.30.50.7-0.70.7-0.70.70.60.6-0.60.50.5-0.50.4-0.4-0.5
Short access day 1 locomotion0.91.41.81.3-1.31.3-1.31.31.31.2-1.21.11.2-1.11.1-1.0-1.0
Short access day 10 total locomotion0.41.61.81.3-1.31.3-1.31.31.31.3-1.31.31.3-1.21.3-1.2-1.1
Short access total locomotion0.00.00.00.1-0.10.1-0.10.10.10.1-0.10.10.1-0.00.0-0.00.2
One hour access (0.3 mA shock)0.40.50.80.9-0.80.8-0.80.70.70.8-0.80.70.5-0.60.5-0.6-0.3
Compulsive drug intake0.10.20.3-0.40.5-0.40.4-0.4-0.4-0.60.5-0.4-0.10.2-0.20.5-0.1
One hour access (shock baseline)0.41.01.31.1-1.11.1-1.11.11.11.1-1.11.10.8-0.90.9-1.0-0.6
Social response proportion0.50.60.9-0.70.8-0.80.8-0.8-0.8-0.70.7-0.7-0.80.8-0.90.70.9
Social responses0.20.20.4-0.50.4-0.40.4-0.4-0.5-0.40.4-0.4-0.60.6-0.60.30.4
Social time1.11.72.3-1.21.1-1.21.2-1.2-1.2-1.31.3-1.3-1.41.5-1.51.41.5
Soleus weight5.416.016.84.0-4.04.0-4.04.04.04.0-4.04.04.1-4.14.1-4.0-3.8
Bone: stiffness0.00.00.20.1-0.20.2-0.20.20.10.3-0.30.30.1-0.10.1-0.4-0.2
Tibialis anterior weight4.114.115.13.8-3.73.7-3.73.73.73.9-3.93.83.8-3.73.7-3.9-3.6
Time to tail flick, vehicle, before self-admin1.41.72.1-1.31.3-1.31.3-1.3-1.3-1.41.4-1.4-1.21.3-1.31.41.1
Time to tail flick, vehicle, after self-admin2.55.05.5-2.32.3-2.22.2-2.2-2.2-2.32.3-2.3-2.22.2-2.12.32.1
Time to tail flick, test, before self-admin0.10.10.20.2-0.20.2-0.20.20.20.2-0.20.20.3-0.30.3-0.2-0.5
Time to tail flick, test, after self-admin0.10.10.20.2-0.30.3-0.20.30.30.4-0.40.40.3-0.30.2-0.40.0
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.20.2-0.20.2-0.2-0.2-0.00.1-0.1-0.20.2-0.10.00.4
Delta time to tail flick, test, before/after SA1.31.61.91.3-1.31.3-1.31.31.31.4-1.41.31.3-1.21.2-1.4-0.9
Tibia length2.87.99.3-2.82.8-2.92.9-2.9-2.9-2.72.7-2.7-3.03.0-3.02.62.6
Ambulatory time before self-admin0.00.00.20.1-0.20.2-0.20.20.20.1-0.10.10.1-0.20.3-0.1-0.5
Ambulatory time after self-admin0.81.21.6-1.11.1-1.11.1-1.1-1.2-1.11.1-1.1-1.31.1-1.11.10.9
Bone: tissue strength0.50.50.6-0.80.8-0.80.8-0.8-0.8-0.70.7-0.6-0.60.6-0.60.50.6
Total heroin consumption3.74.45.22.1-2.12.0-2.02.02.02.3-2.32.21.8-2.12.2-2.3-1.7
Bone: trabecular number3.56.67.02.6-2.62.6-2.52.52.52.6-2.62.62.5-2.52.5-2.7-2.6
Bone: trabecular spacing2.43.63.9-2.02.0-1.91.9-1.9-1.9-2.02.0-1.9-1.71.7-1.72.01.8
Bone: trabecular thickness0.71.01.61.0-1.01.0-0.90.90.91.2-1.21.10.9-0.90.8-1.3-1.0
Bone: trabecular tissue density0.20.30.40.6-0.60.6-0.60.60.60.5-0.50.50.6-0.50.5-0.5-0.5
Water consumed over 24 hours0.51.11.31.0-1.01.0-1.01.01.01.1-1.11.11.0-1.01.0-1.2-0.9
Number of responses in last shaping day0.10.10.2-0.20.2-0.20.2-0.2-0.2-0.40.4-0.4-0.40.5-0.50.50.0