Hub : Genes

Babam2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver isoform ratio XM_006239802.4 0.51 0.43 0.0e+00 0.24 0.25 0.25 0.25 9.9e-27 1.3e-27 2.7e-27 2.6e-27
2 Adipose intron excision ratio chr6_30463558_30467289 0.36 0.3 0.0e+00 0.22 0.22 0.22 0.22 5.7e-24 1.5e-24 4.3e-24 3.2e-24
3 RMTg isoform ratio XM_006239802.4 0.23 0.15 1.3e-05 0.11 0.12 0.1 0.1 7.0e-04 5.2e-04 1.5e-03 1.7e-03
4 Liver isoform ratio NM_199270.2 0.09 0.08 2.2e-08 0.07 0.07 0.07 0.07 1.9e-08 1.8e-08 5.5e-08 5.7e-08
5 Adipose intron excision ratio chr6_30463558_30463859 0.18 0.15 6.7e-16 0.14 0.14 0.14 0.14 5.0e-15 1.6e-15 8.2e-15 3.4e-15
6 Brain gene expression Babam2 0.04 0.03 5.5e-04 0.03 0.03 0.03 0.03 1.6e-03 7.1e-04 1.5e-03 1.2e-03
7 Liver intron excision ratio chr6_30377017_30434771 0.62 0.24 0.0e+00 0.46 0.47 0.48 0.47 2.2e-56 1.2e-58 1.3e-59 7.0e-58
8 Liver intron excision ratio chr6_30377017_30429869 0.64 0.24 0.0e+00 0.46 0.48 0.48 0.47 2.8e-57 1.3e-59 1.1e-60 7.0e-59
9 Liver intron excision ratio chr6_30463558_30467289 0.36 0.26 0.0e+00 0.25 0.25 0.25 0.25 2.7e-27 6.3e-28 4.7e-28 1.2e-27
10 PL gene expression Babam2 0.09 0.07 3.7e-09 0.08 0.08 0.05 0.08 3.7e-09 5.1e-09 8.0e-06 3.1e-09
11 Liver intron excision ratio chr6_30463932_30467289 0.24 0.17 0.0e+00 0.19 0.19 0.19 0.19 5.1e-21 5.3e-21 4.8e-21 6.0e-21
12 Adipose isoform ratio XM_006239802.4 0.18 0.15 1.3e-15 0.13 0.14 0.13 0.14 1.1e-14 4.5e-15 1.1e-14 4.2e-15
13 Liver intron excision ratio chr6_30463558_30463859 0.28 0.22 0.0e+00 0.2 0.2 0.21 0.2 1.8e-21 2.2e-22 2.0e-22 4.3e-22
14 pVTA gene expression Babam2 0.05 0.06 2.0e-03 0.03 0.02 0.02 0.03 1.2e-03 8.6e-03 7.0e-03 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density5.29.010.13.0-3.03.0-3.03.03.0-3.13.1-3.12.92.92.93.22.9
Area under the delay curve0.70.91.70.7-0.70.8-0.80.80.9-0.90.9-0.91.31.11.11.00.7
BMI with tail0.20.70.8-0.90.9-0.90.9-0.9-0.90.8-0.80.8-0.9-0.8-0.7-0.8-0.8
BMI without tail0.72.12.6-1.51.4-1.41.4-1.4-1.41.4-1.41.4-1.6-1.5-1.3-1.5-1.6
Body weight1.98.39.0-3.03.0-3.02.9-2.9-2.92.9-2.92.9-2.9-2.8-2.7-2.8-2.7
Weight adjusted by age0.00.00.00.00.0-0.00.0-0.0-0.10.0-0.00.0-0.2-0.2-0.2-0.00.1
Bone surface2.75.05.82.3-2.22.2-2.22.22.2-2.42.4-2.32.12.12.12.42.1
Bone volume2.95.26.22.3-2.32.3-2.22.22.2-2.42.4-2.42.12.12.12.52.2
Breakpoint value in progressive ratio session1.01.31.81.1-1.01.0-1.01.01.0-1.31.3-1.30.91.21.21.41.1
Number of licking bursts0.20.20.40.4-0.40.4-0.40.40.5-0.50.5-0.50.60.50.50.60.4
Context. condit. distance diff. score0.00.00.00.0-0.00.0-0.00.00.00.0-0.00.00.0-0.00.0-0.1-0.1
Locomotion velocity, session 10.10.10.5-0.10.2-0.20.2-0.2-0.20.1-0.10.2-0.4-0.3-0.3-0.3-0.7
Locomotion distance, session 12.02.52.71.6-1.61.6-1.61.61.6-1.61.6-1.61.51.61.61.51.4
Locomotion velocity, session 20.20.20.3-0.40.4-0.40.4-0.4-0.40.5-0.50.5-0.4-0.4-0.4-0.5-0.5
Locomotion distance, session 20.00.00.10.0-0.0-0.00.0-0.0-0.00.1-0.10.1-0.2-0.1-0.1-0.2-0.3
Locomotion velocity, session 30.50.50.70.8-0.80.8-0.80.70.7-0.80.8-0.80.70.70.70.70.4
Locomotion distance, session 30.80.80.90.9-0.90.9-0.90.90.9-0.90.9-0.90.90.90.90.80.9
Stereotopy head waving bouts, day 31.61.92.01.4-1.41.4-1.41.41.4-1.41.4-1.41.31.41.31.41.3
Stereotopy head waving duration, day 30.10.10.10.3-0.30.3-0.30.30.3-0.30.3-0.30.20.30.20.30.2
Locomotion velocity, session 70.91.01.51.0-1.01.0-1.01.01.0-1.21.2-1.10.80.90.81.20.8
Locomotion distance, session 70.00.00.10.1-0.10.1-0.10.10.1-0.30.3-0.2-0.1-0.1-0.10.3-0.1
Stereotopy head waving bouts, day 70.00.00.10.2-0.20.1-0.20.20.2-0.00.0-0.10.20.20.2-0.00.3
Stereotopy head waving duration, day 70.20.30.50.6-0.60.6-0.60.60.6-0.40.4-0.40.60.60.60.30.7
Locomotion velocity, session 80.00.00.10.2-0.20.2-0.20.20.2-0.20.2-0.1-0.1-0.0-0.00.0-0.3
Locomotion distance, session 80.20.30.40.7-0.60.6-0.60.60.6-0.60.6-0.60.50.60.60.50.3
Degree of sensitization distance0.80.81.1-0.90.9-0.90.9-0.9-1.00.8-0.80.8-1.0-1.0-1.0-0.7-1.1
Degree of sensitization stereotypy0.10.10.3-0.40.4-0.40.4-0.4-0.30.5-0.50.5-0.3-0.3-0.3-0.5-0.1
Conditioned locomotion3.23.74.11.9-1.91.9-1.91.91.9-1.81.9-1.92.01.91.91.82.0
Cocaine response after cond. corrected1.21.41.71.1-1.11.1-1.11.21.2-1.21.2-1.21.31.31.31.21.1
Cocaine response after cond. not corrected2.42.83.11.6-1.61.6-1.61.61.6-1.71.7-1.71.71.81.81.71.6
Cocaine response before conditioning1.01.21.41.2-1.21.2-1.21.21.1-1.21.2-1.11.01.01.01.11.0
Saline control response0.40.50.60.8-0.80.8-0.80.80.8-0.70.7-0.70.70.70.70.60.7
Bone: connectivity density5.07.98.72.8-2.82.8-2.82.82.8-2.92.9-2.92.72.82.72.92.7
Bone: cortical apparent density0.71.01.40.9-1.01.0-1.01.01.0-1.01.0-1.01.11.01.01.01.2
Bone: cortical area0.91.42.11.1-1.11.1-1.11.11.1-1.31.3-1.31.11.01.01.51.2
Bone: cortical porosity0.80.91.11.0-1.01.0-1.01.01.0-0.80.8-0.81.00.90.90.70.7
Bone: cortical porosity0.91.01.21.0-1.11.1-1.11.11.1-1.01.0-1.01.01.01.00.90.8
Bone: cortical thickness0.00.00.10.2-0.20.1-0.10.10.1-0.20.2-0.20.20.10.10.30.2
Bone: cortical thickness1.61.92.01.4-1.41.4-1.41.41.4-1.41.4-1.41.41.31.31.41.2
Bone: cortical tissue density0.50.71.00.8-0.80.8-0.80.80.8-0.80.8-0.81.00.90.90.91.0
Condit. Reinf. active minus inactive responses0.30.40.5-0.70.7-0.70.7-0.7-0.70.5-0.50.5-0.6-0.6-0.6-0.4-0.5
Condit. Reinf. active-inactive response ratio0.40.40.6-0.80.8-0.80.8-0.8-0.70.6-0.60.6-0.6-0.6-0.6-0.4-0.5
Condit. Reinf. active responses0.40.50.80.6-0.60.6-0.60.60.6-0.80.7-0.80.70.70.70.90.7
Condit. Reinf. inactive responses1.92.32.41.6-1.51.5-1.51.51.5-1.51.5-1.61.51.61.51.51.4
Incentive salience index mean0.10.10.40.3-0.20.2-0.30.30.3-0.50.5-0.50.30.30.30.60.4
Condit. Reinf. lever presses1.01.41.81.2-1.11.1-1.11.11.1-1.31.3-1.31.21.21.21.31.2
Condit. Reinf. active minus inactive responses3.64.65.12.2-2.22.2-2.22.22.2-2.12.1-2.12.12.22.22.12.3
Condit. Reinf. active-inactive response ratio0.91.11.31.1-1.11.0-1.11.11.1-0.91.0-1.01.01.11.10.91.1
Condit. Reinf. active responses3.14.44.92.1-2.12.0-2.02.12.0-2.12.1-2.12.02.02.12.22.2
Condit. Reinf. inactive responses1.82.33.41.4-1.41.4-1.41.41.4-1.71.7-1.71.41.41.41.91.5
Condit. Reinf. lever presses2.23.03.31.7-1.71.7-1.71.71.7-1.71.7-1.71.71.81.81.81.8
Condit. Reinf. lever reinforcers received2.73.84.32.0-1.91.9-1.91.91.9-2.02.0-2.01.81.91.92.12.1
Conditioned reinforcement - actives0.20.30.50.6-0.70.7-0.70.70.6-0.40.4-0.40.30.40.40.20.6
Conditioned reinforcement - inactives2.23.33.92.0-1.91.9-1.91.91.9-1.81.8-1.81.71.71.71.71.8
Conditioned locomotion0.40.51.4-0.60.5-0.50.5-0.5-0.60.6-0.60.7-0.9-1.0-0.9-0.8-1.2
Patch foraging indifference point 0 sec0.30.60.7-0.80.8-0.80.8-0.8-0.80.6-0.60.7-0.7-0.8-0.8-0.4-0.6
Patch foraging indifference point AUC1.01.41.81.3-1.31.3-1.31.31.3-1.21.2-1.11.21.11.11.01.0
Delay disc. indifference point, 0s delay1.71.92.3-1.51.5-1.41.4-1.4-1.41.5-1.51.4-1.0-1.2-1.2-1.4-1.4
Delay disc. indifference point, 16s delay0.80.81.40.7-0.70.8-0.80.80.8-0.90.9-1.01.21.11.11.10.8
Delay disc. indifference point, 2s delay0.10.10.5-0.30.3-0.30.3-0.3-0.30.3-0.30.3-0.2-0.3-0.3-0.4-0.7
Delay disc. indifference point, 24s delay3.64.05.71.7-1.71.7-1.81.81.9-1.91.9-2.02.42.32.32.22.2
Delay disc. indifference point, 4s delay0.00.00.10.2-0.20.2-0.20.20.2-0.10.1-0.10.30.20.20.10.3
Delay disc. indifference point, 8s delay0.50.61.30.5-0.50.6-0.60.60.7-0.70.7-0.81.20.91.00.80.6
Indifference point function ln k0.00.00.0-0.10.1-0.00.1-0.1-0.10.1-0.10.1-0.1-0.1-0.1-0.2-0.1
Indifference point function log k0.00.00.0-0.10.1-0.00.1-0.1-0.10.1-0.10.1-0.1-0.1-0.1-0.2-0.1
Patch foraging total patch changes 0 sec0.30.50.6-0.70.8-0.80.8-0.8-0.80.5-0.50.6-0.7-0.8-0.8-0.4-0.6
Patch foraging total patch changes 12 sec0.91.21.4-1.21.1-1.11.1-1.1-1.11.1-1.11.1-1.0-1.2-1.2-1.0-1.1
Patch foraging total patch changes 18 sec0.10.20.3-0.40.4-0.40.4-0.4-0.40.4-0.40.4-0.5-0.5-0.5-0.4-0.5
Patch foraging total patch changes 24 sec1.01.82.1-1.31.3-1.31.3-1.3-1.31.3-1.31.3-1.3-1.4-1.4-1.3-1.4
Patch foraging total patch changes 6 sec0.10.10.2-0.40.4-0.40.4-0.4-0.40.4-0.40.4-0.3-0.4-0.5-0.3-0.2
Patch foraging time to switch 0 sec0.00.10.20.0-0.00.1-0.10.10.1-0.20.2-0.30.30.30.30.40.4
Patch foraging water rate 0 sec0.00.10.2-0.10.1-0.20.2-0.2-0.20.3-0.30.3-0.4-0.3-0.4-0.4-0.4
Patch foraging water rate 12 sec1.22.52.7-1.61.5-1.61.6-1.6-1.61.6-1.61.6-1.6-1.5-1.6-1.6-1.4
Patch foraging water rate 18 sec0.61.01.1-1.01.0-1.01.0-1.0-1.01.1-1.11.1-0.8-1.0-1.0-1.1-1.0
Patch foraging water rate 24 sec2.02.93.4-1.81.7-1.81.8-1.7-1.71.7-1.71.7-1.7-1.7-1.6-1.6-1.5
Patch foraging water rate 6 sec1.42.02.3-1.41.4-1.41.4-1.4-1.41.5-1.51.5-1.5-1.4-1.4-1.5-1.2
Seeking ratio, delayed vs. immediate footshock0.50.61.9-0.60.5-0.50.5-0.5-0.60.7-0.70.8-0.7-0.8-0.7-1.0-1.4
Distance traveled before self-admin0.00.00.1-0.0-0.00.0-0.00.10.10.1-0.10.00.00.10.1-0.00.4
Distance traveled after self-admin1.61.92.2-1.41.4-1.41.4-1.4-1.41.4-1.41.4-1.5-1.3-1.4-1.3-1.1
Extensor digitorum longus weight4.718.619.24.3-4.34.3-4.34.34.3-4.44.4-4.44.34.34.34.44.2
Bone: elastic displacement0.60.70.90.9-0.90.9-0.90.90.9-0.70.8-0.80.90.90.90.70.9
Bone: elastic work1.21.52.11.2-1.21.2-1.21.21.2-1.21.2-1.21.21.21.21.31.4
Bone: endosteal estimation0.71.62.21.2-1.21.2-1.21.21.2-1.41.4-1.41.11.11.11.51.2
Bone: endosteal perimeter0.40.81.30.8-0.80.8-0.80.80.8-1.01.0-1.00.80.80.81.11.0
Epididymis fat weight16.355.858.5-7.77.6-7.67.6-7.6-7.67.5-7.57.4-7.4-7.4-7.4-7.2-7.1
Delta time in closed arm before/after self-admin0.00.00.20.2-0.10.1-0.10.10.1-0.20.2-0.20.30.20.10.30.4
Delta time in open arm before/after self-admin0.20.20.30.3-0.40.4-0.40.40.4-0.50.5-0.40.40.40.50.50.3
Diff in mean of infusions in LGA sessions0.00.00.1-0.1-0.10.0-0.00.00.0-0.00.00.0-0.3-0.1-0.00.0-0.1
Delay discount exponential model param1.41.52.6-1.01.0-1.11.1-1.1-1.21.2-1.21.3-1.6-1.4-1.4-1.3-1.0
Extinction: sum of active levers before priming0.70.71.10.8-0.80.8-0.80.80.8-0.90.9-0.91.01.01.00.90.5
Active lever presses in extinction session 60.10.10.20.4-0.40.4-0.40.40.3-0.40.4-0.40.10.20.20.40.1
Bone: final force0.20.30.60.4-0.40.4-0.40.40.4-0.70.7-0.60.40.40.40.80.4
Bone: final moment0.20.40.80.5-0.50.5-0.50.50.5-0.80.8-0.70.50.50.50.90.4
Food consumed during 24 hour testing period0.20.20.20.5-0.50.5-0.50.50.5-0.50.5-0.40.50.40.40.40.4
Glucose0.30.50.7-0.70.7-0.70.7-0.7-0.70.7-0.70.7-0.8-0.8-0.8-0.7-0.7
Heart weight3.14.85.4-2.12.2-2.22.2-2.2-2.22.2-2.22.2-2.3-2.3-2.3-2.1-2.2
Delay discount hyperbolic model param0.91.01.8-0.80.8-0.90.9-0.9-0.91.0-1.01.0-1.3-1.1-1.1-1.1-0.7
Intermittent access intake day 1-15 change0.10.10.3-0.30.2-0.20.2-0.2-0.30.3-0.30.4-0.5-0.5-0.5-0.4-0.5
Intermittent access intake escalation0.10.30.5-0.50.4-0.40.4-0.4-0.50.5-0.50.6-0.7-0.6-0.7-0.6-0.7
Intermittent access intake escalation 20.30.31.2-0.40.3-0.40.4-0.4-0.50.4-0.40.5-0.8-0.7-0.8-0.6-1.1
Intermitt. access day 1 inactive lever presses0.20.91.31.1-1.01.0-1.01.00.9-0.90.9-0.90.70.80.70.90.9
Intermitt. access day 15 inactive lever presses2.24.66.22.5-2.42.4-2.32.32.2-2.12.1-2.01.91.81.81.82.0
Intermitt. access escalation Index0.30.50.7-0.70.6-0.60.6-0.7-0.70.6-0.60.7-0.7-0.9-0.8-0.7-0.7
Intermittent access day 1 total infusions2.64.14.82.2-2.12.1-2.12.12.1-2.02.0-2.02.01.91.91.92.0
Intermittent access day 15 total infusions0.71.01.31.1-1.11.1-1.11.11.1-1.01.0-1.00.90.90.80.90.8
Intermittent access terminal intake (last 3 days)1.21.62.01.4-1.41.4-1.41.31.3-1.31.3-1.31.11.11.11.21.1
Intermittent access total infusions1.31.51.81.3-1.31.3-1.31.31.3-1.21.2-1.21.21.21.21.11.3
Intermittent access day 1 locomotion1.82.22.41.5-1.51.5-1.51.51.5-1.51.5-1.51.51.51.51.51.4
Intermittent access day 15 total locomotion0.00.00.10.2-0.30.2-0.20.20.2-0.10.1-0.10.00.10.00.0-0.1
Intermittent access total locomotion0.00.00.10.2-0.30.3-0.30.30.3-0.20.2-0.20.20.20.20.1-0.0
Intermittent access standard deviation0.40.91.11.0-1.01.0-1.01.01.0-1.01.0-1.00.80.90.80.90.8
Left kidney weight0.00.00.0-0.10.1-0.20.1-0.1-0.10.1-0.10.1-0.2-0.0-0.1-0.0-0.1
Right kidney weight0.20.81.1-1.01.1-1.01.0-1.0-1.00.9-0.90.9-0.7-0.7-0.7-0.8-0.8
Cocaine induced anxiety0.10.20.20.4-0.40.4-0.40.40.4-0.50.5-0.40.20.30.20.50.2
Post-drug Anxiety1.11.21.4-1.11.1-1.11.1-1.1-1.11.2-1.21.2-1.1-1.1-1.1-1.1-0.6
Baseline Anxiety2.73.13.7-1.81.8-1.81.8-1.8-1.81.9-1.91.9-1.6-1.6-1.6-1.8-1.2
Tail length0.62.32.7-1.51.4-1.51.5-1.5-1.51.5-1.51.5-1.7-1.5-1.5-1.5-1.4
Length with tail2.08.69.1-3.03.0-3.03.0-3.0-3.03.0-3.03.0-2.9-2.9-2.9-2.9-2.7
Length without tail0.61.92.1-1.41.5-1.41.4-1.4-1.41.4-1.41.4-1.2-1.4-1.4-1.3-1.2
Times rat made contact with spout2.73.13.41.7-1.71.7-1.71.71.7-1.81.8-1.81.81.81.81.91.8
Lifetime Intake1.21.51.91.4-1.31.3-1.31.31.3-1.21.2-1.21.11.21.11.11.2
Liver weight, left3.76.16.5-2.42.5-2.52.5-2.5-2.52.4-2.42.4-2.6-2.5-2.5-2.3-2.4
Liver weight, right10.017.518.0-4.24.2-4.24.2-4.2-4.24.1-4.14.1-4.2-4.2-4.2-4.0-4.2
Locomotor activity0.00.00.1-0.30.3-0.30.3-0.3-0.20.2-0.20.10.0-0.1-0.0-0.0-0.2
Locomotor testing distance0.30.60.80.6-0.60.7-0.70.70.7-0.80.8-0.80.90.80.90.80.6
Locomotor testing rearing0.40.81.00.8-0.90.9-0.90.90.9-1.01.0-1.00.80.90.91.00.8
Locomotion in novel chamber0.40.50.7-0.80.8-0.80.8-0.8-0.80.6-0.60.7-0.8-0.8-0.8-0.5-0.6
Locomotion in novel chamber post-restriction2.33.84.6-2.22.1-2.12.1-2.0-2.01.9-1.91.9-1.9-1.8-1.8-1.8-1.8
Fecal boli incidents, locomotor time 10.30.40.80.5-0.60.7-0.70.70.7-0.40.4-0.50.90.60.70.40.8
Change in fecal boli incidents, locomotor task4.04.04.3-1.92.1-2.12.1-2.1-2.12.0-2.01.9-2.0-1.9-2.0-1.9-1.9
Time >=10cm from walls, locomotor time 10.00.00.20.10.00.0-0.00.00.10.0-0.0-0.10.50.30.30.10.3
Bouts of movement, locomotor time 12.52.83.51.5-1.61.7-1.71.71.7-1.61.6-1.61.91.71.81.61.7
Total resting periods, locomotor time 12.62.93.61.6-1.71.7-1.71.71.7-1.61.6-1.61.91.71.81.71.8
Rest time, locomotor task time 10.10.10.2-0.30.3-0.30.3-0.3-0.30.3-0.30.3-0.2-0.3-0.3-0.3-0.4
Distance moved, locomotor task time 10.50.81.0-0.91.0-1.01.0-1.0-1.00.8-0.80.8-0.9-0.9-1.0-0.7-0.8
Vertical activity count, locomotor time 10.10.30.4-0.40.6-0.60.6-0.6-0.60.5-0.50.5-0.6-0.4-0.5-0.4-0.2
Time >=10cm from walls, locomotor time 20.00.10.10.3-0.30.3-0.30.30.3-0.30.3-0.20.30.20.20.2-0.1
Bouts of movement, locomotor time 20.00.00.1-0.20.1-0.10.1-0.1-0.10.3-0.30.30.0-0.1-0.0-0.3-0.0
Total resting periods, locomotor time 20.00.00.10.1-0.10.2-0.10.10.10.0-0.00.00.20.10.1-0.10.2
Rest time, locomotor task time 21.41.82.11.3-1.41.4-1.41.41.4-1.31.3-1.31.41.41.41.31.1
Distance moved, locomotor task time 21.21.41.8-1.11.2-1.31.2-1.3-1.31.0-1.01.1-1.3-1.3-1.3-0.9-1.1
Vertical activity count, locomotor time 20.71.01.3-0.91.0-1.01.0-1.0-1.01.0-1.01.0-1.1-1.1-1.1-0.9-0.7
Light reinforcement 13.38.19.32.8-2.82.8-2.82.82.8-2.92.9-2.92.92.72.73.02.9
Light reinforcement 23.14.85.22.3-2.22.3-2.22.22.2-2.22.2-2.22.22.12.12.22.1
Bone: marrow area0.71.62.21.2-1.21.2-1.21.21.2-1.41.4-1.41.11.11.11.51.2
Bone: maximum diameter1.52.73.81.6-1.61.6-1.61.61.6-1.81.8-1.81.51.51.51.91.7
Bone: maximum force0.20.30.70.5-0.50.5-0.50.50.5-0.70.7-0.70.50.50.50.90.5
Bone: maximum moment0.30.51.00.7-0.60.6-0.60.60.6-0.90.9-0.80.60.60.61.00.6
Mean time between licks in bursts1.53.63.8-1.91.9-1.91.9-1.9-1.91.9-1.91.9-1.9-1.9-1.9-1.9-1.8
Mean num. licks in bursts0.10.10.30.4-0.40.3-0.30.30.3-0.30.3-0.30.30.30.30.30.5
Cd content in liver0.00.00.10.1-0.10.1-0.10.10.1-0.10.1-0.10.20.20.20.10.2
Co content in liver6.87.98.12.8-2.82.8-2.82.82.8-2.82.8-2.82.82.82.82.82.8
Cu content in liver0.10.10.10.3-0.30.3-0.30.30.3-0.30.3-0.30.40.30.40.30.2
Fe content in liver0.50.60.70.8-0.80.8-0.80.80.8-0.80.8-0.80.80.70.70.80.7
K content in liver0.50.40.60.7-0.70.7-0.70.70.7-0.80.8-0.70.50.60.60.70.4
Mg content in liver0.60.60.80.8-0.80.8-0.80.80.8-0.90.9-0.90.70.80.70.90.6
Mn content in liver0.00.00.10.2-0.20.2-0.20.20.2-0.30.3-0.20.10.10.20.2-0.1
Na content in liver0.30.40.40.6-0.70.7-0.70.60.6-0.60.6-0.60.60.50.50.60.4
Rb content in liver0.00.00.10.2-0.10.2-0.20.20.2-0.20.2-0.20.20.20.20.20.2
Se content in liver0.30.40.5-0.60.5-0.50.6-0.6-0.60.5-0.50.6-0.7-0.7-0.7-0.5-0.7
Sr content in liver0.10.10.1-0.30.3-0.30.3-0.3-0.30.2-0.20.2-0.2-0.2-0.2-0.2-0.3
Zn content in liver0.80.91.0-0.91.0-1.01.0-1.0-1.00.9-0.90.9-1.0-1.0-1.0-0.9-0.9
Bone: minimum diameter0.00.00.1-0.20.2-0.20.2-0.2-0.2-0.10.1-0.0-0.3-0.3-0.20.3-0.0
Time in familiar zone, hab. session 10.70.70.9-0.90.9-0.80.9-0.9-0.90.8-0.90.9-0.8-0.9-1.0-0.8-0.7
Time in novel zone, hab. session 10.70.70.9-0.90.9-0.90.9-0.9-0.90.8-0.80.8-0.9-0.8-0.8-0.9-1.0
Total zone transitions, hab. session 10.10.20.20.4-0.40.4-0.40.40.4-0.50.5-0.50.30.40.40.50.4
Total locomotion distance, hab. session 10.10.20.20.4-0.40.4-0.40.40.4-0.40.4-0.40.30.30.40.40.4
Locomotion velocity, hab. session 11.11.51.61.2-1.31.3-1.21.31.2-1.31.3-1.31.11.21.21.31.2
Time in familiar zone, hab. session 20.00.00.10.0-0.0-0.00.0-0.0-0.0-0.10.1-0.1-0.2-0.1-0.10.1-0.3
Time in novel zone, hab. session 20.40.40.5-0.70.7-0.60.6-0.6-0.60.7-0.70.6-0.4-0.5-0.5-0.6-0.4
Total zone transitions, hab. session 20.20.20.30.5-0.50.5-0.50.50.5-0.50.5-0.50.40.50.50.50.4
Total locomotion distance, hab. session 20.20.30.30.6-0.60.6-0.60.60.6-0.50.5-0.50.50.60.60.40.5
Locomotion velocity, hab. session 20.50.60.70.8-0.80.8-0.80.80.8-0.70.7-0.70.80.80.90.70.8
Novel to familiar place preference ratio0.70.71.0-0.90.9-0.90.9-0.9-0.91.0-1.00.9-0.6-0.7-0.8-0.9-0.5
Novelty place preference1.21.31.7-1.21.2-1.21.2-1.2-1.11.3-1.31.2-0.9-1.0-1.1-1.2-0.8
Time in novel zone, NPP test1.51.62.0-1.31.3-1.31.3-1.3-1.31.4-1.41.4-1.1-1.2-1.2-1.3-1.0
Total zone transitions, NPP test1.52.22.41.5-1.51.5-1.51.51.5-1.51.5-1.51.41.51.51.41.2
Total locomotion distance, NPP test1.92.62.81.7-1.71.7-1.71.71.7-1.61.6-1.61.51.61.61.51.6
Locomotion velocity, NPP test3.44.85.02.2-2.22.2-2.22.22.2-2.12.1-2.22.12.22.22.12.2
Intraocular pressure4.15.86.7-2.52.6-2.62.6-2.6-2.52.4-2.42.3-2.3-2.3-2.3-2.2-2.2
Delta distance traveled before/after self-admin2.12.22.7-1.41.5-1.51.5-1.5-1.51.4-1.41.4-1.6-1.6-1.6-1.4-1.6
Delta ambulatory time before/after self-admin0.20.30.6-0.40.5-0.50.5-0.5-0.50.3-0.30.4-0.6-0.6-0.6-0.4-0.8
Parametrial fat weight10.624.925.5-5.05.0-5.05.0-5.0-5.05.0-5.05.0-4.9-5.0-5.0-4.9-4.9
Pavlov. Cond. lever latency1.92.42.6-1.61.6-1.61.6-1.6-1.61.6-1.61.6-1.6-1.5-1.5-1.6-1.4
Pavlov. Cond. magazine entry latency0.10.10.10.4-0.30.3-0.30.30.3-0.30.3-0.30.30.30.30.20.2
Pavlov. Cond. change in total contacts0.10.10.10.3-0.20.3-0.20.20.3-0.20.2-0.30.30.20.20.30.2
Pavlov. Cond. index score0.81.01.21.1-1.01.0-1.01.01.0-1.01.0-1.01.01.00.91.00.9
Pavlov. Cond. latency score0.81.01.11.1-1.01.0-1.01.01.0-1.01.0-1.01.00.90.91.00.8
Pavlov. Cond. lever contacts1.31.61.71.3-1.31.3-1.31.31.3-1.31.3-1.31.31.21.21.31.2
Pavlov. Cond. magazine entry number0.50.60.7-0.80.8-0.80.8-0.8-0.80.8-0.80.8-0.7-0.7-0.7-0.7-0.6
Pavlov. Cond. intertrial magazine entries1.61.92.51.3-1.31.3-1.31.31.3-1.51.5-1.51.41.41.41.61.3
Pavlov. Cond. lever-magazine prob. diff.1.72.02.21.5-1.41.4-1.41.41.4-1.41.4-1.41.51.41.41.41.4
Pavlov. Cond. response bias1.41.71.91.4-1.31.3-1.31.31.3-1.31.3-1.31.31.31.31.31.3
Pavlov. Cond. lever latency1.52.12.5-1.41.4-1.41.4-1.4-1.41.4-1.41.4-1.4-1.4-1.4-1.4-1.6
Pavlov. Cond. magazine entry latency0.10.10.10.4-0.40.4-0.40.40.3-0.40.4-0.30.20.20.20.30.3
Pavlov. Cond. change in total contacts0.61.01.61.0-1.01.0-1.01.01.0-0.90.9-0.91.01.11.10.91.3
Pavlov. Cond. index score0.91.31.61.1-1.21.2-1.21.11.1-1.11.1-1.11.11.11.11.11.2
Pavlov. Cond. latency score0.91.21.41.1-1.11.1-1.11.11.1-1.01.0-1.01.01.01.01.01.2
Pavlov. Cond. lever contacts1.11.62.11.2-1.21.2-1.21.21.2-1.21.2-1.21.21.31.31.31.5
Pavlov. Cond. magazine entry number0.10.10.2-0.30.4-0.40.4-0.4-0.30.4-0.40.4-0.2-0.2-0.3-0.4-0.4
Pavlov. Cond. intertrial magazine entries2.94.44.9-2.22.2-2.22.2-2.2-2.22.0-2.02.0-2.1-2.0-2.0-1.9-2.0
Pavlov. Cond. lever-magazine prob. diff.0.60.81.00.9-0.90.9-0.90.90.9-0.90.9-0.90.80.80.80.91.0
Pavlov. Cond. response bias1.82.43.01.5-1.51.5-1.51.51.5-1.51.5-1.61.51.51.51.61.7
Time in closed arm before self-admin1.11.42.2-1.21.1-1.21.2-1.2-1.21.0-1.11.1-1.4-1.3-1.2-1.1-1.5
Time in closed arm after self-admin1.61.82.2-1.41.3-1.41.4-1.3-1.41.2-1.21.2-1.3-1.4-1.4-1.2-1.5
Time in open arm before self-admin0.30.30.80.5-0.50.5-0.50.50.5-0.40.4-0.50.60.70.60.50.9
Time in open arm after self-admin1.92.02.31.4-1.41.4-1.41.41.4-1.41.4-1.41.51.41.51.41.4
Bone: periosteal estimation1.32.73.81.6-1.61.6-1.61.61.5-1.81.8-1.81.51.51.52.01.7
Bone: periosteal perimeter0.71.21.91.0-1.01.0-1.01.01.0-1.21.2-1.21.01.01.01.41.2
Bone: post-yield work0.81.21.41.0-1.11.1-1.11.11.1-1.21.1-1.11.11.01.01.21.0
Progressive ratio test 1 active lever presses0.91.11.31.1-1.11.1-1.11.11.1-1.11.0-1.11.01.01.01.01.0
Progressive ratio test 1 breakpoint1.01.21.41.2-1.11.1-1.11.11.1-1.11.1-1.11.11.11.11.11.1
Progressive ratio test 1 inactive lever presses1.31.92.61.6-1.61.6-1.51.51.5-1.21.2-1.21.21.31.21.01.4
Progressive ratio test 2 active lever presses0.00.00.00.1-0.10.1-0.10.00.0-0.00.0-0.0-0.2-0.1-0.10.00.1
Progressive ratio test 2 breakpoint0.00.00.10.00.0-0.00.0-0.0-0.10.0-0.00.1-0.2-0.2-0.2-0.0-0.0
Progressive ratio test 2 inactive lever presses0.20.40.70.8-0.80.8-0.80.70.7-0.60.6-0.60.30.40.30.50.6
Incentive Sensitization - Responses0.00.00.1-0.0-0.00.0-0.00.0-0.0-0.00.00.0-0.3-0.1-0.20.10.1
Incentive Sensitization - Breakpoint0.00.10.2-0.20.1-0.10.1-0.2-0.20.1-0.10.2-0.5-0.3-0.4-0.1-0.1
Sum of active levers in priming session hrs 5-61.21.11.41.0-1.01.0-1.01.01.0-1.11.1-1.21.01.11.01.20.9
Progressive ratio0.30.41.0-0.30.5-0.60.6-0.6-0.60.6-0.60.6-1.0-0.8-0.9-0.7-0.6
Food seeking constrained by brief footshock1.61.92.61.6-1.61.6-1.61.61.5-1.21.2-1.21.41.31.21.01.2
Seeking ratio, punishment vs. effort0.60.91.60.8-0.91.0-1.01.01.0-0.80.8-0.81.31.11.10.81.0
Retroperitoneal fat weight21.893.096.1-9.79.8-9.89.8-9.8-9.89.6-9.69.6-9.5-9.7-9.7-9.3-9.4
Reaction time number correct0.51.01.11.0-1.01.0-1.01.01.0-1.01.0-1.00.91.01.11.01.0
Reaction time mean minus median0.00.10.2-0.20.2-0.10.1-0.2-0.10.3-0.30.3-0.0-0.2-0.2-0.4-0.3
Reaction time mean minus median AUC0.10.10.3-0.30.3-0.30.3-0.3-0.30.4-0.40.4-0.1-0.3-0.3-0.5-0.4
Reaction time num false alarms0.20.20.60.4-0.30.3-0.30.40.4-0.40.4-0.50.60.50.50.60.7
Reaction time num false alarms AUC0.20.40.80.5-0.40.5-0.50.50.5-0.60.6-0.60.70.60.60.80.9
Reaction time trials correct on left0.51.01.11.0-1.01.0-1.01.01.0-1.01.0-1.00.91.01.11.01.0
Reaction time trials on left0.61.11.21.1-1.11.0-1.01.11.0-1.01.1-1.00.91.01.11.01.0
Reaction time mean1.11.81.8-1.31.3-1.31.3-1.3-1.31.3-1.31.3-1.3-1.3-1.3-1.3-1.4
Reaction time mean AUC0.91.41.5-1.21.2-1.21.2-1.2-1.21.2-1.21.2-1.2-1.2-1.2-1.1-1.2
Median of all reaction times1.31.82.0-1.31.4-1.41.4-1.4-1.41.3-1.31.3-1.4-1.4-1.4-1.2-1.3
Reaction time omissions0.00.10.10.2-0.30.3-0.30.30.3-0.30.3-0.30.20.20.30.30.2
Reaction time false alarm rate0.00.00.1-0.00.1-0.10.1-0.1-0.0-0.10.1-0.10.20.10.10.30.3
Reaction time premature initiation rate0.20.20.5-0.50.5-0.40.4-0.4-0.40.7-0.60.6-0.1-0.4-0.4-0.7-0.5
Reaction time premature initiations0.00.00.10.1-0.10.2-0.20.20.20.1-0.10.00.40.20.2-0.20.0
Std. dev. reaction times0.40.70.8-0.80.8-0.80.8-0.8-0.80.8-0.80.9-0.8-0.9-0.8-0.9-0.9
Reaction time trials completed0.61.11.21.1-1.11.0-1.01.11.0-1.01.1-1.00.91.01.11.01.0
Reaction time trials AUC0.71.31.41.2-1.21.1-1.11.11.1-1.21.2-1.21.01.11.21.11.1
Run reversals in cocaine runway, females0.00.00.1-0.10.1-0.10.1-0.1-0.00.3-0.30.30.10.00.1-0.30.3
Run reversals in cocaine runway, males0.30.31.10.5-0.40.4-0.50.50.5-0.30.3-0.40.70.70.70.41.0
Latency to leave start box in cocaine runway0.30.30.40.5-0.60.6-0.60.60.6-0.60.6-0.60.50.50.50.50.1
Latency to leave start box in cocaine runway, F0.30.40.60.5-0.60.6-0.60.60.6-0.70.7-0.70.60.60.60.80.7
Latency to leave start box in cocaine runway, M0.20.21.2-0.20.1-0.20.2-0.2-0.20.3-0.30.4-0.4-0.4-0.4-0.6-1.1
Std. dev. time between licks in bursts0.10.10.1-0.30.2-0.30.3-0.3-0.30.2-0.20.2-0.4-0.3-0.3-0.2-0.3
Total sessions with >9 infusions0.10.10.20.5-0.40.4-0.40.40.4-0.40.4-0.30.40.30.30.30.3
Short access day 1 total inactive lever presses5.37.08.42.9-2.92.9-2.82.82.8-2.52.5-2.52.52.52.52.22.6
Short access day 10 total inactive lever presses1.63.94.62.1-2.02.0-2.02.02.0-1.91.9-1.91.91.91.91.82.0
Short access day 1 total infusions1.41.92.51.5-1.61.5-1.51.51.5-1.31.3-1.31.31.11.11.11.3
Short access day 10 total infusions1.51.92.21.5-1.41.4-1.41.41.4-1.31.3-1.31.41.41.31.21.4
Short access total infusions0.30.30.50.7-0.70.7-0.70.70.6-0.60.6-0.50.50.50.40.40.5
Short access day 1 locomotion1.21.41.81.3-1.31.3-1.31.31.3-1.21.2-1.11.21.11.11.01.0
Short access day 10 total locomotion0.91.61.81.3-1.31.3-1.31.31.3-1.31.3-1.31.31.21.31.21.1
Short access total locomotion0.00.00.00.1-0.10.1-0.10.10.1-0.10.1-0.10.10.00.00.0-0.2
One hour access (0.3 mA shock)0.40.50.80.9-0.80.8-0.80.70.7-0.80.8-0.70.50.60.50.60.3
Compulsive drug intake0.10.20.3-0.40.5-0.40.4-0.4-0.40.6-0.50.4-0.1-0.2-0.2-0.50.1
One hour access (shock baseline)0.71.01.31.1-1.11.1-1.11.11.1-1.11.1-1.10.80.90.91.00.6
Social response proportion0.50.60.9-0.70.8-0.80.8-0.8-0.80.7-0.70.7-0.8-0.8-0.9-0.7-0.9
Social responses0.20.20.4-0.50.4-0.40.4-0.4-0.50.4-0.40.4-0.6-0.6-0.6-0.3-0.4
Social time1.31.72.3-1.21.1-1.21.2-1.2-1.21.3-1.31.3-1.4-1.5-1.5-1.4-1.5
Soleus weight5.416.016.84.0-4.04.0-4.04.04.0-4.04.0-4.04.14.14.14.03.8
Bone: stiffness0.00.00.20.1-0.20.2-0.20.20.1-0.30.3-0.30.10.10.10.40.2
Tibialis anterior weight4.214.115.13.8-3.73.7-3.73.73.7-3.93.9-3.83.83.73.73.93.6
Time to tail flick, vehicle, before self-admin1.71.72.1-1.31.3-1.31.3-1.3-1.31.4-1.41.4-1.2-1.3-1.3-1.4-1.1
Time to tail flick, vehicle, after self-admin3.85.05.5-2.32.3-2.22.2-2.2-2.22.3-2.32.3-2.2-2.2-2.1-2.3-2.1
Time to tail flick, test, before self-admin0.10.10.20.2-0.20.2-0.20.20.2-0.20.2-0.20.30.30.30.20.5
Time to tail flick, test, after self-admin0.10.10.20.2-0.30.3-0.20.30.3-0.40.4-0.40.30.30.20.4-0.0
Delta time to tail flick, vehicle, before/after SA0.00.00.2-0.20.2-0.20.2-0.2-0.20.0-0.10.1-0.2-0.2-0.2-0.0-0.4
Delta time to tail flick, test, before/after SA1.61.61.91.3-1.31.3-1.31.31.3-1.41.4-1.31.31.21.21.40.9
Tibia length2.97.99.3-2.82.8-2.92.9-2.9-2.92.7-2.72.7-3.0-3.0-3.0-2.6-2.6
Ambulatory time before self-admin0.00.00.20.1-0.20.2-0.20.20.2-0.10.1-0.10.10.20.30.10.5
Ambulatory time after self-admin1.11.21.6-1.11.1-1.11.1-1.1-1.21.1-1.11.1-1.3-1.1-1.1-1.1-0.9
Bone: tissue strength0.50.50.6-0.80.8-0.80.8-0.8-0.80.7-0.70.6-0.6-0.6-0.6-0.5-0.6
Total heroin consumption3.74.45.22.1-2.12.0-2.02.02.0-2.32.3-2.21.82.12.22.31.7
Bone: trabecular number4.06.67.02.6-2.62.6-2.52.52.5-2.62.6-2.62.52.52.52.72.6
Bone: trabecular spacing2.73.63.9-2.02.0-1.91.9-1.9-1.92.0-2.01.9-1.7-1.7-1.7-2.0-1.8
Bone: trabecular thickness0.81.01.61.0-1.01.0-0.90.90.9-1.21.2-1.10.90.90.81.31.0
Bone: trabecular tissue density0.20.30.40.6-0.60.6-0.60.60.6-0.50.5-0.50.60.50.50.50.5
Water consumed over 24 hours0.81.11.31.0-1.01.0-1.01.01.0-1.11.1-1.11.01.01.01.20.9
Number of responses in last shaping day0.10.10.2-0.20.2-0.20.2-0.2-0.20.4-0.40.4-0.4-0.5-0.5-0.5-0.0