Hub : Genes

Smim26

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative polyA NM_001106520.1 0.18 0.08 6.7e-08 0.12 0.08 0.14 0.12 5.3e-06 2.7e-04 1.4e-06 7.5e-06
2 Liver gene expression Smim26 0.08 0.05 6.0e-06 0.04 0.03 0.03 0.03 2.4e-05 2.7e-04 3.2e-04 1.7e-04
3 pVTA alternative polyA XM_006235125.4 0.17 0.08 2.6e-07 0.1 0.07 0.12 0.1 4.2e-05 7.8e-04 7.7e-06 3.0e-05
4 PL alternative polyA NM_001106520.1 0.16 0.06 0.0e+00 0.22 0.19 0.22 0.22 5.2e-24 1.8e-20 9.0e-24 5.9e-24
5 PL alternative polyA XM_006235125.4 0.15 0.06 0.0e+00 0.21 0.19 0.22 0.22 4.1e-23 3.3e-20 2.3e-23 1.2e-23
6 BLA alternative polyA XM_006235125.4 0.13 0.07 1.3e-05 0.07 0.07 0.06 0.07 1.2e-04 1.7e-04 5.8e-04 1.2e-04
7 Brain gene expression Smim26 0.05 0.03 8.8e-04 0.04 0.04 0.04 0.04 9.6e-05 1.6e-04 1.7e-04 4.6e-05
8 Brain alternative polyA NM_001106520.1 0.23 0.09 0.0e+00 0.24 0.19 0.21 0.22 4.7e-22 2.5e-17 1.7e-19 1.9e-20
9 Brain alternative polyA XM_006235125.4 0.23 0.09 0.0e+00 0.24 0.19 0.21 0.22 5.6e-22 3.2e-17 2.9e-19 2.1e-20
10 NAcc alternative polyA XM_006235125.4 0.16 0.07 0.0e+00 0.2 0.16 0.16 0.19 4.0e-22 1.1e-17 1.1e-18 4.5e-21
11 NAcc alternative polyA NM_001106520.1 0.16 0.07 0.0e+00 0.2 0.16 0.17 0.19 1.6e-22 6.7e-18 1.0e-19 2.2e-21
12 PL gene expression Smim26 0.02 0.02 9.6e-03 0.02 0.02 0.01 0.01 9.1e-04 3.9e-03 8.5e-03 5.9e-02
13 LHb alternative polyA NM_001106520.1 0.37 0.17 4.2e-05 0.18 0.1 0.14 0.15 4.6e-05 2.3e-03 4.2e-04 1.8e-04
14 LHb alternative polyA XM_006235125.4 0.38 0.18 3.0e-05 0.18 0.1 0.14 0.16 5.0e-05 1.8e-03 3.4e-04 1.0e-04
15 OFC alternative polyA NM_001106520.1 0.3 0.14 1.6e-05 0.24 0.19 0.21 0.12 2.3e-06 3.1e-05 8.6e-06 1.0e-03
16 OFC alternative polyA XM_006235125.4 0.29 0.14 3.9e-05 0.22 0.18 0.2 0.13 7.3e-06 3.6e-05 1.5e-05 6.6e-04
17 RMTg intron excision ratio chr3_131990452_131991296 0.34 0.2 2.2e-03 0.01 0 -0.01 -0 1.5e-01 2.4e-01 7.7e-01 4.4e-01
18 IL alternative polyA XM_006235125.4 0.31 0.19 3.6e-04 0.1 0.11 0.08 0.09 2.5e-03 1.2e-03 6.6e-03 3.3e-03
19 IL alternative polyA NM_001106520.1 0.32 0.2 2.6e-04 0.1 0.12 0.07 0.1 1.8e-03 9.1e-04 8.6e-03 2.3e-03
20 BLA alternative polyA NM_001106520.1 0.13 0.07 1.2e-05 0.07 0.07 0.06 0.07 1.2e-04 8.6e-05 4.3e-04 7.7e-05
21 RMTg intron excision ratio chr3_131977504_131977978 0.2 0.1 3.2e-04 0.04 0.04 0 0.03 4.0e-02 2.9e-02 2.4e-01 5.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.30.46.80.00.0-0.20.30.3-0.4-0.40.3-0.3-0.20.10.30.6-0.60.5-0.50.20.5-0.52.6-0.4
Area under the delay curve0.70.74.41.40.9-1.40.40.4-0.4-0.60.4-0.4-0.30.10.60.5-0.50.7-0.72.1-0.20.2-1.41.0
BMI with tail5.517.927.2-4.5-5.24.4-5.0-5.04.84.4-4.74.74.9-5.1-4.8-3.63.6-4.14.1-0.8-4.04.01.12.7
BMI without tail3.87.915.6-3.4-4.03.6-3.3-3.33.13.0-2.92.93.1-3.2-2.9-2.62.6-2.72.7-1.3-2.22.20.61.1
Body weight5.322.241.5-5.2-6.45.1-5.8-5.85.64.9-5.55.55.5-5.6-5.0-3.43.4-3.73.7-2.3-4.14.12.72.0
Weight adjusted by age0.60.75.60.4-0.3-0.50.10.1-0.2-0.50.1-0.1-0.20.20.61.0-1.01.2-1.2-0.90.7-0.62.4-1.0
Bone surface0.40.74.0-1.3-0.71.2-0.4-0.40.50.7-0.50.50.6-0.5-0.7-0.90.9-1.11.1-0.3-0.40.42.0-0.1
Bone volume0.20.46.8-0.5-0.50.40.10.1-0.0-0.0-0.00.00.1-0.00.10.2-0.20.1-0.1-0.60.3-0.32.6-0.7
Breakpoint value in progressive ratio session0.50.51.3-1.0-0.71.1-0.5-0.50.50.7-0.50.50.5-0.6-0.5-1.01.0-1.01.0-0.6-0.50.5-1.10.1
Number of licking bursts0.20.20.80.5-0.2-0.5-0.4-0.40.4-0.1-0.30.30.3-0.30.10.7-0.70.6-0.60.8-0.10.1-0.90.6
Context. condit. distance diff. score0.00.00.20.2-0.3-0.1-0.0-0.00.1-0.1-0.10.10.2-0.1-0.1-0.00.00.1-0.1-0.40.3-0.30.4-0.3
Locomotion velocity, session 10.80.92.00.21.2-0.11.41.4-1.4-0.81.4-1.4-1.41.40.9-0.20.2-0.20.2-0.10.8-0.8-0.0-1.0
Locomotion distance, session 13.03.86.82.22.6-2.22.22.2-2.2-2.02.3-2.3-2.22.32.21.7-1.71.7-1.70.51.6-1.6-1.1-1.2
Locomotion velocity, session 20.91.14.31.12.1-1.11.21.2-1.3-0.81.3-1.3-1.31.31.20.2-0.20.5-0.51.40.3-0.3-0.60.0
Locomotion distance, session 24.56.38.52.42.4-2.32.82.8-2.9-2.62.9-2.9-2.92.82.92.4-2.42.4-2.4-0.52.7-2.70.3-2.4
Locomotion velocity, session 32.22.53.91.92.0-1.91.81.8-1.9-1.81.8-1.8-1.81.81.71.4-1.41.4-1.40.91.3-1.3-0.6-0.7
Locomotion distance, session 30.80.91.91.31.2-1.40.90.9-1.0-1.10.9-0.9-0.80.90.90.8-0.80.9-0.91.20.6-0.6-0.4-0.1
Stereotopy head waving bouts, day 30.10.10.8-0.5-0.10.50.00.0-0.10.10.1-0.1-0.00.0-0.1-0.20.2-0.30.3-0.9-0.00.00.5-0.3
Stereotopy head waving duration, day 30.10.20.5-0.7-0.40.7-0.1-0.10.20.3-0.20.20.2-0.2-0.3-0.50.5-0.50.5-0.7-0.20.20.6-0.1
Locomotion velocity, session 71.31.42.41.61.0-1.61.21.2-1.1-1.21.1-1.1-1.11.01.31.3-1.31.6-1.6-0.51.0-1.0-0.1-1.3
Locomotion distance, session 70.60.81.81.00.2-1.00.60.6-0.6-0.90.6-0.6-0.50.51.01.3-1.31.3-1.3-1.10.7-0.70.0-1.3
Stereotopy head waving bouts, day 70.10.10.2-0.2-0.50.2-0.3-0.30.30.3-0.30.30.4-0.3-0.3-0.30.3-0.10.1-0.0-0.10.10.3-0.0
Stereotopy head waving duration, day 70.00.10.50.20.3-0.20.30.3-0.3-0.00.2-0.2-0.20.20.1-0.10.10.0-0.00.70.2-0.2-0.00.2
Locomotion velocity, session 81.01.22.20.91.2-0.71.31.3-1.5-1.11.4-1.4-1.41.51.00.3-0.30.5-0.5-0.81.2-1.2-0.6-1.3
Locomotion distance, session 82.53.64.62.11.8-2.02.02.0-2.0-2.12.0-2.0-2.02.12.11.8-1.81.9-1.9-0.72.1-2.1-0.1-1.9
Degree of sensitization distance0.30.33.6-0.3-0.80.4-0.3-0.30.40.2-0.30.30.3-0.30.10.3-0.30.3-0.3-1.90.1-0.10.4-1.1
Degree of sensitization stereotypy0.30.40.6-0.4-0.80.4-0.7-0.70.70.7-0.70.70.8-0.8-0.6-0.60.6-0.40.40.5-0.50.40.20.5
Conditioned locomotion0.60.71.70.50.3-0.40.90.9-0.9-1.10.9-0.9-0.90.90.70.3-0.30.6-0.6-0.81.0-1.01.3-1.3
Cocaine response after cond. corrected2.22.54.51.81.0-1.81.61.6-1.3-1.51.3-1.3-1.41.41.92.1-2.12.1-2.1-0.81.5-1.5-0.5-1.6
Cocaine response after cond. not corrected3.94.37.82.31.4-2.32.02.0-1.8-2.01.7-1.7-1.81.82.42.8-2.82.8-2.8-0.72.0-2.00.7-1.9
Cocaine response before conditioning0.40.45.00.20.4-0.40.30.3-0.4-0.50.5-0.5-0.40.40.40.6-0.60.7-0.70.40.4-0.42.2-0.3
Saline control response0.81.07.3-1.2-1.21.3-0.3-0.30.00.3-0.00.00.0-0.00.0-0.10.1-0.10.1-2.70.6-0.72.1-1.8
Bone: connectivity density0.20.22.6-0.00.5-0.00.50.5-0.5-0.40.5-0.5-0.40.30.1-0.10.1-0.10.10.60.3-0.31.6-0.2
Bone: cortical apparent density0.20.21.2-0.00.5-0.1-0.1-0.10.1-0.0-0.10.10.2-0.3-0.5-0.40.4-0.60.61.1-0.50.5-0.41.0
Bone: cortical area0.30.51.3-0.8-0.30.7-0.8-0.80.60.6-0.60.60.6-0.6-0.8-0.60.6-0.90.9-0.0-0.80.81.10.6
Bone: cortical porosity0.70.71.7-1.2-0.51.3-0.7-0.70.61.0-0.50.50.6-0.5-0.8-1.11.1-1.31.3-0.1-0.70.7-0.90.7
Bone: cortical porosity0.80.91.8-1.2-0.71.3-0.9-0.90.81.0-0.70.70.8-0.7-1.0-1.21.2-1.31.3-0.2-0.90.8-0.40.8
Bone: cortical thickness0.81.32.8-1.10.11.0-0.9-0.90.70.8-0.80.80.7-0.8-1.4-1.51.5-1.71.71.2-1.31.30.41.6
Bone: cortical thickness0.50.62.21.11.5-1.20.70.7-0.7-1.10.7-0.7-0.70.70.60.6-0.60.5-0.51.20.2-0.20.20.3
Bone: cortical tissue density0.10.20.8-0.10.4-0.0-0.1-0.10.10.0-0.20.20.2-0.3-0.5-0.40.4-0.50.50.9-0.40.4-0.30.9
Condit. Reinf. active minus inactive responses0.30.31.00.4-0.3-0.50.20.2-0.1-0.20.1-0.10.0-0.00.41.0-1.01.0-1.00.00.6-0.60.8-0.3
Condit. Reinf. active-inactive response ratio0.30.41.20.6-0.3-0.60.30.3-0.2-0.30.1-0.1-0.0-0.00.51.1-1.11.1-1.10.10.6-0.60.6-0.3
Condit. Reinf. active responses0.20.30.90.50.0-0.60.30.3-0.2-0.30.2-0.2-0.20.20.50.9-0.90.9-0.90.20.5-0.50.8-0.2
Condit. Reinf. inactive responses0.00.00.2-0.10.30.1-0.0-0.0-0.10.00.2-0.2-0.10.2-0.0-0.30.3-0.20.2-0.3-0.10.1-0.4-0.2
Incentive salience index mean0.30.31.50.70.6-0.80.30.3-0.2-0.20.2-0.2-0.20.20.50.9-0.90.9-0.91.20.2-0.20.40.4
Condit. Reinf. lever presses0.40.55.20.30.7-0.6-0.3-0.30.40.4-0.40.40.4-0.4-0.10.2-0.20.2-0.22.3-0.80.8-0.21.5
Condit. Reinf. active minus inactive responses0.91.12.8-1.5-1.41.5-0.8-0.80.81.0-0.80.80.9-0.9-1.0-1.11.1-1.01.0-1.2-0.50.51.7-0.3
Condit. Reinf. active-inactive response ratio0.90.92.2-1.4-1.51.5-0.9-0.91.01.3-1.11.11.0-1.0-0.8-0.80.8-0.80.8-0.5-0.50.50.80.0
Condit. Reinf. active responses0.81.22.0-1.3-0.91.2-0.9-0.91.01.0-1.01.01.0-1.0-1.3-1.41.4-1.41.4-0.1-1.01.01.10.6
Condit. Reinf. inactive responses0.50.61.3-0.30.30.2-0.5-0.50.50.2-0.40.40.4-0.5-1.0-1.11.1-1.11.10.9-1.11.10.11.1
Condit. Reinf. lever presses2.53.56.4-2.5-2.42.5-1.9-1.91.92.1-1.91.91.8-1.8-2.0-1.91.9-1.81.8-0.8-1.21.22.10.5
Condit. Reinf. lever reinforcers received1.11.62.6-1.6-1.21.6-1.1-1.11.11.3-1.11.11.1-1.1-1.5-1.61.6-1.61.6-0.3-1.11.11.00.6
Conditioned reinforcement - actives1.61.63.30.70.7-0.61.31.3-1.2-0.91.2-1.2-1.21.21.41.5-1.51.4-1.4-1.51.6-1.60.2-1.8
Conditioned reinforcement - inactives2.73.15.31.30.7-1.21.81.8-1.7-1.71.6-1.6-1.51.51.72.3-2.32.1-2.1-1.92.0-2.0-0.4-2.3
Conditioned locomotion0.20.20.80.20.6-0.20.90.9-0.7-0.20.6-0.6-0.50.40.40.3-0.3-0.10.10.50.5-0.5-0.5-0.1
Patch foraging indifference point 0 sec1.11.85.20.9-0.0-0.81.31.3-1.0-1.30.9-0.9-0.91.01.01.5-1.51.4-1.4-2.21.6-1.61.3-2.3
Patch foraging indifference point AUC0.30.31.20.60.8-0.50.60.6-0.6-0.50.6-0.6-0.40.50.50.1-0.10.1-0.11.00.3-0.3-1.10.2
Delay disc. indifference point, 0s delay0.70.81.9-0.5-0.70.5-0.7-0.70.81.0-0.90.91.0-1.2-0.7-0.70.7-0.50.51.3-1.11.1-1.21.4
Delay disc. indifference point, 16s delay1.41.43.01.71.7-1.71.01.0-1.1-1.21.1-1.1-0.91.01.41.0-1.01.2-1.21.50.6-0.6-0.90.2
Delay disc. indifference point, 2s delay0.91.02.8-0.1-0.60.0-0.9-0.91.01.0-1.11.11.1-1.2-0.6-0.40.4-0.20.21.7-1.21.2-1.41.6
Delay disc. indifference point, 24s delay4.03.89.33.02.3-3.01.71.7-1.7-2.21.9-1.9-1.81.62.02.1-2.12.1-2.11.71.0-1.0-1.8-0.0
Delay disc. indifference point, 4s delay0.40.41.70.7-0.1-0.6-0.6-0.60.60.1-0.40.40.4-0.6-0.10.3-0.30.3-0.31.2-0.70.8-1.31.0
Delay disc. indifference point, 8s delay1.01.02.61.61.4-1.41.01.0-1.1-1.01.0-1.0-1.00.80.90.4-0.40.5-0.51.60.5-0.5-1.60.4
Indifference point function ln k0.50.72.60.30.1-0.40.70.7-0.5-0.60.6-0.6-0.50.50.51.0-1.00.8-0.8-1.60.8-0.81.6-1.4
Indifference point function log k0.50.72.60.30.1-0.40.70.7-0.5-0.60.6-0.6-0.50.50.51.0-1.00.8-0.8-1.60.8-0.81.6-1.4
Patch foraging total patch changes 0 sec1.11.94.91.00.2-0.91.41.4-1.1-1.41.1-1.1-1.11.21.11.5-1.51.3-1.3-1.91.7-1.71.3-2.2
Patch foraging total patch changes 12 sec0.10.20.4-0.0-0.60.1-0.5-0.50.50.2-0.60.60.7-0.6-0.5-0.20.2-0.30.3-0.2-0.40.4-0.50.1
Patch foraging total patch changes 18 sec1.21.62.51.40.7-1.31.31.3-1.2-1.61.3-1.3-1.21.21.21.5-1.51.2-1.2-0.91.6-1.50.1-1.5
Patch foraging total patch changes 24 sec0.10.20.40.30.1-0.30.20.2-0.3-0.40.3-0.3-0.20.40.50.7-0.70.4-0.4-0.10.5-0.50.4-0.5
Patch foraging total patch changes 6 sec0.40.61.51.0-0.1-1.00.60.6-0.4-0.80.4-0.4-0.30.40.71.2-1.21.1-1.1-0.50.9-0.90.5-1.0
Patch foraging time to switch 0 sec1.52.33.9-1.3-1.31.4-2.0-2.01.81.7-1.81.81.5-1.6-1.7-1.31.3-1.21.2-0.1-1.71.7-1.21.4
Patch foraging water rate 0 sec1.72.84.61.91.7-1.92.12.1-2.0-1.91.8-1.8-1.61.71.81.6-1.61.4-1.40.51.7-1.70.5-1.1
Patch foraging water rate 12 sec2.23.46.62.42.4-2.62.02.0-2.0-2.21.9-1.9-1.71.72.02.0-2.01.8-1.81.51.4-1.30.8-0.5
Patch foraging water rate 18 sec9.212.418.24.33.6-4.33.63.6-3.8-3.93.6-3.6-3.73.64.13.8-3.83.8-3.80.03.2-3.2-0.5-2.6
Patch foraging water rate 24 sec4.05.68.42.91.7-2.82.52.5-2.5-2.62.3-2.3-2.32.22.82.5-2.52.6-2.6-0.42.5-2.5-0.9-2.1
Patch foraging water rate 6 sec3.95.78.22.72.7-2.82.62.6-2.7-2.92.7-2.7-2.62.62.72.4-2.42.2-2.20.52.2-2.20.3-1.5
Seeking ratio, delayed vs. immediate footshock0.20.30.8-0.8-0.40.9-0.1-0.10.50.6-0.40.40.2-0.2-0.4-0.40.4-0.60.6-0.8-0.40.4-0.90.0
Distance traveled before self-admin0.40.41.5-0.2-0.30.2-0.6-0.60.60.7-0.70.70.6-0.6-0.4-0.50.5-0.30.30.2-0.90.9-1.20.7
Distance traveled after self-admin0.70.84.2-0.00.10.1-0.2-0.20.30.4-0.40.40.4-0.3-0.8-1.21.2-1.11.11.8-0.60.7-2.11.5
Extensor digitorum longus weight0.10.31.2-0.7-0.90.7-0.4-0.40.50.5-0.40.40.5-0.4-0.2-0.10.1-0.20.2-1.1-0.10.11.0-0.4
Bone: elastic displacement0.91.02.4-0.9-0.11.0-0.7-0.70.80.9-0.70.70.8-0.8-1.0-1.51.5-1.41.40.7-1.31.3-1.21.0
Bone: elastic work2.93.84.6-2.1-1.52.1-2.1-2.12.12.1-2.02.02.1-2.1-2.2-2.12.1-2.12.10.6-2.12.1-0.41.7
Bone: endosteal estimation0.81.75.5-1.4-2.31.4-1.4-1.41.41.3-1.31.31.3-1.1-0.50.2-0.20.1-0.1-2.2-0.20.22.4-1.0
Bone: endosteal perimeter0.30.74.1-0.4-1.20.5-0.1-0.10.10.1-0.10.10.1-0.00.40.7-0.70.6-0.6-2.00.7-0.71.8-1.5
Epididymis fat weight3.68.314.4-3.2-3.83.1-3.6-3.63.63.1-3.33.33.3-3.3-3.0-2.22.2-2.22.2-1.4-2.62.61.41.2
Delta time in closed arm before/after self-admin0.20.20.40.60.2-0.50.60.6-0.5-0.50.4-0.4-0.30.20.20.6-0.60.4-0.4-0.40.6-0.6-0.1-0.6
Delta time in open arm before/after self-admin1.41.42.5-1.5-1.61.4-1.3-1.31.41.5-1.51.51.3-1.3-1.2-1.01.0-1.01.0-0.1-1.01.00.40.7
Diff in mean of infusions in LGA sessions0.20.22.10.50.5-0.60.20.2-0.00.1-0.00.0-0.10.10.40.4-0.40.4-0.40.9-0.20.2-1.50.5
Delay discount exponential model param0.90.94.2-1.6-1.11.6-0.5-0.50.50.8-0.60.60.5-0.3-0.8-0.70.7-0.80.8-2.00.0-0.11.4-0.9
Extinction: sum of active levers before priming0.20.20.80.20.0-0.10.40.4-0.5-0.30.5-0.5-0.30.30.50.4-0.40.4-0.4-0.90.6-0.6-0.8-0.8
Active lever presses in extinction session 60.80.83.6-1.3-1.31.4-0.5-0.50.40.7-0.50.50.6-0.6-0.7-1.01.0-0.90.9-1.9-0.30.2-0.1-0.6
Bone: final force0.40.61.3-0.7-0.90.7-1.1-1.10.90.8-1.01.00.9-0.9-0.8-0.20.2-0.50.5-0.0-0.80.81.00.6
Bone: final moment0.30.51.2-0.7-0.80.7-1.0-1.00.90.7-0.90.90.8-0.8-0.7-0.20.2-0.50.5-0.1-0.70.71.10.4
Food consumed during 24 hour testing period0.10.10.50.3-0.1-0.4-0.7-0.70.2-0.0-0.00.00.1-0.10.20.6-0.60.6-0.6-0.2-0.20.2-0.1-0.0
Glucose0.40.62.8-1.0-1.30.9-0.6-0.60.30.6-0.50.50.6-0.7-0.5-0.10.1-0.00.0-1.7-0.0-0.01.5-0.9
Heart weight1.31.83.5-1.6-1.91.6-1.7-1.71.61.5-1.61.61.5-1.3-1.3-1.11.1-1.21.2-0.9-1.01.00.40.4
Delay discount hyperbolic model param0.60.73.9-1.4-0.81.4-0.3-0.30.20.5-0.30.30.3-0.1-0.6-0.60.6-0.70.7-2.00.2-0.21.4-1.0
Intermittent access intake day 1-15 change0.60.63.4-1.2-1.01.2-0.2-0.20.50.8-0.50.50.6-0.6-0.5-0.10.1-0.40.4-1.8-0.00.00.9-0.8
Intermittent access intake escalation0.40.32.9-0.8-0.80.80.00.00.20.5-0.30.30.3-0.4-0.20.4-0.40.0-0.0-1.70.2-0.20.6-0.9
Intermittent access intake escalation 20.50.53.0-1.0-1.41.0-0.3-0.30.50.7-0.50.50.6-0.8-0.50.5-0.50.1-0.1-1.70.1-0.10.5-0.8
Intermitt. access day 1 inactive lever presses0.40.44.60.20.2-0.40.10.1-0.1-0.20.1-0.1-0.00.00.21.2-1.20.6-0.6-0.40.3-0.32.2-0.5
Intermitt. access day 15 inactive lever presses0.80.97.9-0.6-1.20.60.10.10.20.1-0.20.20.3-0.3-0.30.8-0.80.6-0.6-2.80.4-0.41.9-1.7
Intermitt. access escalation Index2.01.76.5-2.0-1.42.0-0.9-0.90.81.0-0.70.70.7-0.7-1.2-1.91.9-1.51.5-1.1-0.60.52.5-0.1
Intermittent access day 1 total infusions0.20.20.8-0.6-0.10.6-0.3-0.30.20.3-0.20.20.4-0.4-0.3-0.90.9-0.80.8-0.1-0.50.5-0.10.2
Intermittent access day 15 total infusions0.40.52.4-1.1-0.81.1-0.3-0.30.40.6-0.40.40.6-0.8-0.5-0.40.4-0.70.7-1.6-0.30.30.6-0.5
Intermittent access terminal intake (last 3 days)0.70.71.8-1.3-0.71.3-0.6-0.60.60.9-0.60.60.8-1.0-0.7-0.90.9-1.11.1-1.3-0.70.70.5-0.2
Intermittent access total infusions0.50.61.4-1.2-0.81.2-0.5-0.50.50.8-0.50.50.7-0.7-0.6-0.90.9-1.01.0-1.1-0.40.40.1-0.2
Intermittent access day 1 locomotion0.60.71.7-0.80.30.7-0.4-0.40.30.6-0.30.30.5-0.5-0.5-1.31.3-1.31.31.1-0.90.90.01.1
Intermittent access day 15 total locomotion0.30.31.6-1.0-0.60.9-0.2-0.20.20.5-0.30.30.7-0.6-0.3-0.30.3-0.40.4-0.2-0.20.11.3-0.0
Intermittent access total locomotion0.20.20.6-0.60.20.5-0.1-0.10.10.4-0.20.20.5-0.4-0.2-0.60.6-0.80.80.7-0.50.5-0.10.7
Intermittent access standard deviation0.40.41.4-0.0-0.1-0.00.80.8-0.5-0.10.4-0.4-0.40.30.30.9-0.90.5-0.5-1.20.7-0.7-0.7-1.0
Left kidney weight0.82.34.3-2.1-1.92.0-1.8-1.81.81.7-1.61.61.7-1.4-1.5-1.41.4-1.11.1-1.1-1.21.21.40.5
Right kidney weight0.71.93.4-1.7-1.71.7-1.8-1.81.81.6-1.61.61.5-1.2-1.3-1.11.1-0.80.8-1.4-1.11.10.90.3
Cocaine induced anxiety0.60.71.30.60.7-0.51.01.0-0.9-1.01.0-1.0-1.01.00.60.2-0.20.4-0.4-1.10.9-0.9-0.2-1.1
Post-drug Anxiety0.50.62.6-0.5-1.30.6-0.8-0.80.90.7-0.90.90.7-0.7-0.6-0.50.5-0.30.3-1.6-0.30.30.1-0.5
Baseline Anxiety1.92.15.6-1.6-2.41.6-1.7-1.71.71.8-1.91.91.7-1.6-1.4-0.80.8-1.01.0-0.8-1.01.00.50.4
Tail length0.10.43.2-0.7-1.20.9-0.6-0.60.60.4-0.50.50.4-0.40.00.0-0.00.2-0.2-1.80.0-0.10.4-1.0
Length with tail0.62.35.7-1.9-2.41.9-1.8-1.81.81.5-1.71.71.5-1.4-1.1-0.70.7-0.70.7-2.0-0.80.82.3-0.4
Length without tail0.81.84.2-1.5-1.61.4-1.6-1.61.51.4-1.61.61.4-1.4-1.4-0.80.8-1.01.0-0.8-1.01.02.10.4
Times rat made contact with spout2.52.95.2-2.3-2.02.3-1.9-1.91.81.9-1.61.61.7-1.7-1.8-1.81.8-1.61.6-0.6-1.51.50.90.7
Lifetime Intake0.30.31.0-0.8-0.70.9-0.3-0.30.30.5-0.30.30.5-0.5-0.3-0.60.6-0.70.7-1.0-0.10.1-0.3-0.3
Liver weight, left0.10.11.0-0.2-0.30.1-0.1-0.10.30.1-0.20.20.4-0.3-0.10.1-0.10.0-0.0-0.3-0.20.21.0-0.1
Liver weight, right0.00.00.10.30.2-0.4-0.1-0.10.1-0.1-0.10.10.1-0.00.10.2-0.20.3-0.3-0.2-0.20.2-0.10.0
Locomotor activity0.20.30.6-0.6-0.70.7-0.6-0.60.40.5-0.40.40.5-0.5-0.5-0.70.7-0.50.5-0.0-0.30.3-0.70.3
Locomotor testing distance0.00.10.30.00.20.00.20.2-0.5-0.20.5-0.5-0.30.30.2-0.10.1-0.10.10.20.3-0.3-0.6-0.1
Locomotor testing rearing0.10.20.6-0.5-0.80.6-0.5-0.50.30.5-0.20.20.4-0.4-0.5-0.60.6-0.60.60.20.1-0.1-0.80.2
Locomotion in novel chamber1.62.03.30.90.6-0.81.61.6-1.5-1.61.5-1.5-1.51.61.41.2-1.21.2-1.2-1.11.8-1.81.5-1.8
Locomotion in novel chamber post-restriction1.72.12.81.71.3-1.71.51.5-1.7-1.61.6-1.6-1.71.61.71.4-1.41.2-1.20.41.6-1.60.7-1.0
Fecal boli incidents, locomotor time 12.42.74.11.81.2-1.61.41.4-1.6-1.71.6-1.6-1.71.72.01.8-1.82.0-2.0-1.01.7-1.7-0.6-1.7
Change in fecal boli incidents, locomotor task0.30.31.0-0.40.20.40.00.00.2-0.00.2-0.2-0.00.0-0.6-0.90.9-1.01.00.4-0.10.11.00.2
Time >=10cm from walls, locomotor time 10.40.40.70.80.5-0.80.60.6-0.5-0.70.6-0.6-0.60.60.50.7-0.70.7-0.7-0.00.8-0.80.5-0.6
Bouts of movement, locomotor time 12.52.74.61.81.4-1.81.51.5-1.5-1.71.7-1.7-1.71.52.11.9-1.92.1-2.1-0.41.4-1.4-1.1-1.3
Total resting periods, locomotor time 13.33.66.12.01.8-2.01.81.8-1.8-1.92.0-2.0-2.11.92.52.1-2.12.3-2.3-0.71.7-1.7-0.9-1.6
Rest time, locomotor task time 11.51.63.91.20.6-1.20.90.9-0.8-1.11.1-1.1-1.00.91.71.8-1.82.0-2.0-0.91.2-1.2-0.5-1.3
Distance moved, locomotor task time 10.60.64.50.41.2-0.50.10.1-0.10.1-0.10.1-0.10.2-0.4-0.60.6-0.70.72.1-0.90.9-1.01.6
Vertical activity count, locomotor time 10.70.81.1-0.6-0.50.5-1.0-1.00.91.0-1.11.10.7-0.7-0.9-0.70.7-0.90.90.8-1.01.00.91.0
Time >=10cm from walls, locomotor time 21.11.12.4-1.3-1.51.3-1.1-1.11.21.3-1.21.21.2-1.2-1.1-0.90.9-0.80.8-0.6-0.80.80.70.3
Bouts of movement, locomotor time 20.40.52.0-0.7-0.30.8-0.4-0.40.20.7-0.40.40.3-0.3-0.5-1.11.1-1.01.00.2-0.60.6-1.40.6
Total resting periods, locomotor time 20.40.41.6-0.7-0.40.8-0.3-0.30.20.6-0.40.40.2-0.3-0.5-1.01.0-0.90.9-0.1-0.50.5-1.20.4
Rest time, locomotor task time 20.30.31.80.70.2-0.60.50.5-0.3-0.70.6-0.6-0.50.30.50.3-0.30.5-0.5-0.70.3-0.3-1.3-0.5
Distance moved, locomotor task time 20.20.21.50.40.8-0.40.50.5-0.6-0.10.3-0.3-0.20.30.30.5-0.50.4-0.41.2-0.00.0-0.60.6
Vertical activity count, locomotor time 20.20.21.1-0.4-0.00.3-0.4-0.40.20.7-0.50.50.4-0.3-0.4-0.10.1-0.20.21.1-0.40.40.50.8
Light reinforcement 10.61.12.40.7-0.1-0.60.70.7-1.0-0.80.7-0.7-0.70.71.21.5-1.51.4-1.4-1.31.3-1.30.4-1.6
Light reinforcement 20.81.13.6-0.30.20.51.11.1-1.2-0.81.2-1.2-1.31.31.0-0.10.10.3-0.3-1.91.4-1.40.3-1.8
Bone: marrow area0.81.65.7-1.4-2.31.4-1.3-1.31.31.3-1.31.31.3-1.1-0.50.2-0.20.1-0.1-2.2-0.20.22.4-1.0
Bone: maximum diameter0.40.74.0-0.8-1.40.8-0.8-0.80.70.6-0.80.80.7-0.7-0.40.3-0.30.1-0.1-1.6-0.20.22.0-0.7
Bone: maximum force0.20.41.7-0.6-0.80.5-0.9-0.90.70.5-0.70.70.6-0.6-0.50.2-0.2-0.10.1-0.6-0.30.31.30.1
Bone: maximum moment0.20.41.7-0.6-0.70.5-0.9-0.90.70.5-0.70.70.6-0.6-0.50.1-0.1-0.10.1-0.4-0.40.41.30.2
Mean time between licks in bursts0.30.40.70.60.5-0.60.70.7-0.7-0.80.7-0.7-0.70.60.50.3-0.30.3-0.30.20.8-0.80.6-0.3
Mean num. licks in bursts0.91.12.7-1.6-0.81.6-0.7-0.70.61.0-0.60.60.6-0.7-1.0-1.51.5-1.31.3-1.1-0.70.71.5-0.3
Cd content in liver0.60.61.20.1-1.1-0.2-1.0-1.01.10.7-1.11.11.1-1.1-0.40.6-0.60.8-0.80.6-0.60.6-0.30.7
Co content in liver0.30.31.70.80.9-0.80.60.6-0.6-0.50.5-0.5-0.50.40.60.4-0.40.5-0.51.30.2-0.2-0.20.2
Cu content in liver0.60.71.41.20.6-1.10.70.7-0.8-0.90.8-0.8-0.80.60.90.9-0.91.0-1.0-0.40.7-0.7-1.2-0.7
Fe content in liver0.30.41.0-0.8-1.00.8-0.6-0.60.60.8-0.70.70.7-0.8-0.7-0.20.2-0.40.4-0.4-0.20.2-0.40.2
K content in liver0.90.96.00.81.8-0.90.50.5-0.4-0.30.4-0.4-0.40.40.1-0.20.2-0.40.42.4-0.50.5-2.11.4
Mg content in liver0.50.52.5-0.20.50.1-0.0-0.00.30.4-0.40.40.4-0.4-0.6-0.70.7-0.80.81.6-0.70.8-0.91.3
Mn content in liver1.51.73.31.01.3-0.91.81.8-1.6-1.61.6-1.6-1.61.71.30.6-0.60.6-0.6-0.11.5-1.40.8-1.3
Na content in liver1.92.04.8-1.00.11.0-0.8-0.80.91.3-0.90.90.9-1.1-1.6-1.91.9-1.91.92.2-1.41.4-1.32.1
Rb content in liver0.30.41.40.9-0.0-1.0-0.4-0.40.4-0.1-0.50.50.5-0.6-0.20.7-0.70.5-0.50.8-0.40.4-1.20.8
Se content in liver0.30.41.40.20.3-0.2-0.6-0.60.60.3-0.50.50.5-0.5-0.4-0.40.4-0.30.31.2-1.01.0-0.91.1
Sr content in liver0.80.81.10.70.7-0.70.80.8-0.9-1.01.1-1.1-1.11.11.00.8-0.80.8-0.8-0.50.9-0.90.8-0.9
Zn content in liver0.10.10.60.30.6-0.30.00.0-0.1-0.10.3-0.3-0.30.30.2-0.00.0-0.00.00.8-0.00.0-0.30.4
Bone: minimum diameter0.50.93.1-1.2-1.01.2-1.0-1.00.90.9-0.90.90.8-0.8-1.0-0.80.8-1.01.0-0.7-0.60.61.80.1
Time in familiar zone, hab. session 10.80.71.7-0.4-0.40.2-0.9-0.90.91.0-1.01.01.0-1.0-0.7-0.40.4-0.40.41.3-1.11.10.71.3
Time in novel zone, hab. session 10.30.21.5-0.3-0.40.50.30.3-0.3-0.30.4-0.4-0.30.30.2-0.10.10.1-0.1-1.20.7-0.7-0.4-1.0
Total zone transitions, hab. session 10.60.82.30.81.5-0.81.01.0-1.1-0.81.2-1.2-1.11.21.10.7-0.70.8-0.80.50.4-0.5-0.8-0.4
Total locomotion distance, hab. session 11.21.73.71.31.9-1.31.41.4-1.7-1.21.6-1.6-1.51.61.41.0-1.01.0-1.00.10.8-0.8-1.4-0.6
Locomotion velocity, hab. session 11.42.04.61.62.2-1.61.61.6-1.8-1.41.7-1.7-1.71.71.51.1-1.11.1-1.10.40.9-0.9-1.1-0.6
Time in familiar zone, hab. session 20.20.20.5-0.10.50.10.50.5-0.5-0.30.7-0.7-0.70.70.4-0.00.0-0.00.0-0.60.7-0.70.4-0.5
Time in novel zone, hab. session 20.50.51.5-0.6-1.20.6-0.8-0.80.80.7-1.01.01.0-1.1-0.6-0.30.3-0.20.2-0.2-0.60.60.20.2
Total zone transitions, hab. session 20.30.41.40.00.2-0.00.50.5-0.5-0.30.6-0.6-0.60.70.70.6-0.60.4-0.4-0.80.7-0.71.2-1.0
Total locomotion distance, hab. session 21.31.74.00.40.7-0.31.41.4-1.4-1.01.4-1.4-1.51.51.40.9-0.90.7-0.7-1.61.8-1.81.4-2.0
Locomotion velocity, hab. session 21.62.13.60.71.2-0.71.71.7-1.7-1.31.7-1.7-1.81.81.61.0-1.00.9-0.9-1.21.8-1.91.3-1.9
Novel to familiar place preference ratio0.10.20.50.0-0.6-0.0-0.3-0.30.30.1-0.40.40.4-0.40.10.7-0.70.5-0.5-0.30.1-0.1-0.2-0.1
Novelty place preference0.20.20.5-0.0-0.6-0.0-0.4-0.40.40.2-0.50.50.5-0.5-0.00.7-0.70.5-0.5-0.00.00.0-0.10.2
Time in novel zone, NPP test0.30.31.1-0.4-1.10.3-0.7-0.70.70.5-0.70.70.8-0.7-0.20.5-0.50.3-0.3-0.3-0.10.1-0.10.1
Total zone transitions, NPP test0.60.81.30.91.1-0.81.01.0-1.0-0.91.1-1.1-1.11.11.10.8-0.81.0-1.00.10.8-0.8-0.1-0.7
Total locomotion distance, NPP test1.92.63.51.21.3-1.21.81.8-1.8-1.61.9-1.9-1.81.81.81.4-1.41.5-1.5-0.91.8-1.80.9-1.9
Locomotion velocity, NPP test2.13.04.11.51.7-1.51.91.9-2.0-1.82.0-2.0-2.02.01.91.5-1.51.6-1.6-0.61.9-1.91.0-1.8
Intraocular pressure3.14.37.12.41.4-2.41.71.7-1.7-2.31.9-1.9-1.92.02.52.6-2.62.7-2.7-0.92.1-2.10.7-2.2
Delta distance traveled before/after self-admin0.70.85.5-0.1-0.20.2-0.4-0.40.40.3-0.50.50.6-0.6-1.0-1.11.1-1.21.22.3-0.50.5-0.71.5
Delta ambulatory time before/after self-admin0.30.43.40.1-0.10.0-0.1-0.10.1-0.0-0.20.20.3-0.3-0.6-0.60.6-0.70.71.8-0.00.1-0.91.0
Parametrial fat weight9.718.928.9-5.3-4.95.4-4.6-4.64.74.8-4.64.64.6-4.6-4.6-4.64.6-4.54.5-1.2-4.04.01.12.2
Pavlov. Cond. lever latency0.81.08.5-1.4-1.61.6-0.4-0.40.30.4-0.20.20.2-0.3-0.5-0.80.8-0.80.8-2.90.3-0.30.4-1.3
Pavlov. Cond. magazine entry latency0.40.52.8-0.20.10.1-0.5-0.50.50.5-0.50.50.6-0.6-0.9-0.60.6-0.70.71.7-0.80.8-0.51.4
Pavlov. Cond. change in total contacts1.21.39.51.81.6-2.00.30.3-0.3-0.70.3-0.3-0.30.30.50.9-0.90.9-0.93.1-0.20.2-0.71.5
Pavlov. Cond. index score0.70.89.00.61.0-0.8-0.2-0.20.30.2-0.30.30.3-0.3-0.4-0.10.1-0.10.13.0-0.90.9-0.81.9
Pavlov. Cond. latency score0.70.99.81.11.3-1.30.20.2-0.1-0.20.0-0.0-0.00.10.10.3-0.30.3-0.33.1-0.50.5-0.61.7
Pavlov. Cond. lever contacts0.50.66.60.81.0-1.0-0.1-0.10.20.1-0.30.30.3-0.20.10.3-0.30.4-0.42.6-0.70.7-0.41.4
Pavlov. Cond. magazine entry number0.70.93.10.10.1-0.00.90.9-0.9-0.70.9-0.9-0.90.91.00.5-0.50.6-0.6-1.81.1-1.11.0-1.6
Pavlov. Cond. intertrial magazine entries2.32.87.30.70.2-0.61.61.6-1.6-1.51.5-1.5-1.61.61.61.4-1.41.4-1.4-2.72.2-2.21.8-2.7
Pavlov. Cond. lever-magazine prob. diff.0.81.09.80.50.9-0.7-0.4-0.40.40.4-0.50.50.5-0.5-0.6-0.20.2-0.30.33.1-1.11.1-0.82.1
Pavlov. Cond. response bias0.60.85.20.30.4-0.5-0.7-0.70.70.5-0.80.80.8-0.7-0.6-0.10.1-0.10.12.3-1.11.1-0.61.7
Pavlov. Cond. lever latency3.54.78.02.42.8-2.32.82.8-2.6-2.42.5-2.5-2.52.52.21.6-1.61.5-1.50.72.0-1.9-1.7-1.0
Pavlov. Cond. magazine entry latency1.21.36.6-1.5-1.81.6-1.0-1.00.80.8-0.70.70.7-0.7-0.5-0.30.3-0.40.4-2.5-0.0-0.02.6-1.1
Pavlov. Cond. change in total contacts4.66.48.8-3.0-2.82.9-2.8-2.82.82.9-2.82.82.8-2.6-2.7-2.52.5-2.42.4-0.5-2.32.31.51.4
Pavlov. Cond. index score3.54.58.9-2.6-3.02.6-2.6-2.62.42.4-2.42.42.4-2.3-2.1-1.61.6-1.51.5-1.4-1.61.62.00.5
Pavlov. Cond. latency score2.73.46.4-2.2-2.52.2-2.3-2.32.12.0-2.12.12.1-2.0-1.8-1.41.4-1.31.3-1.1-1.51.41.80.6
Pavlov. Cond. lever contacts2.83.86.6-2.2-2.62.2-2.6-2.62.42.2-2.32.32.3-2.2-2.0-1.41.4-1.31.3-0.7-1.71.71.50.9
Pavlov. Cond. magazine entry number2.12.55.22.12.3-2.11.81.8-1.6-1.71.6-1.6-1.61.51.41.1-1.11.0-1.02.01.0-1.0-2.00.2
Pavlov. Cond. intertrial magazine entries0.70.93.01.31.3-1.40.90.9-0.8-1.00.8-0.8-0.90.80.90.8-0.80.7-0.71.70.6-0.5-0.20.3
Pavlov. Cond. lever-magazine prob. diff.4.15.28.7-2.8-3.02.7-2.8-2.82.52.6-2.52.52.6-2.5-2.4-1.91.9-1.81.8-1.2-1.91.91.90.9
Pavlov. Cond. response bias2.63.57.2-2.3-2.72.3-2.4-2.42.12.0-2.02.02.0-1.9-1.8-1.31.3-1.21.2-1.7-1.31.32.10.2
Time in closed arm before self-admin0.40.51.30.40.5-0.40.60.6-0.5-0.70.7-0.7-0.80.90.50.6-0.60.7-0.7-1.10.6-0.60.5-1.0
Time in closed arm after self-admin1.31.32.70.90.8-0.81.31.3-1.2-1.11.2-1.2-1.21.20.81.0-1.01.0-1.0-1.51.2-1.30.4-1.6
Time in open arm before self-admin1.11.22.9-1.0-0.41.0-0.7-0.70.70.9-0.70.70.8-0.9-1.0-1.71.7-1.61.61.4-0.90.9-0.51.3
Time in open arm after self-admin3.94.38.0-2.2-1.42.2-1.8-1.81.82.1-1.91.91.9-1.9-2.1-2.82.8-2.72.71.4-2.02.0-0.72.2
Bone: periosteal estimation0.61.25.4-1.4-1.61.3-1.2-1.21.11.1-1.11.11.1-0.9-0.7-0.30.3-0.50.5-1.5-0.50.52.3-0.4
Bone: periosteal perimeter0.20.32.0-0.8-0.80.8-0.3-0.30.20.3-0.20.20.2-0.1-0.1-0.10.1-0.30.3-1.10.1-0.11.4-0.6
Bone: post-yield work0.10.21.0-0.0-0.2-0.00.10.1-0.1-0.00.1-0.1-0.10.10.30.8-0.80.6-0.6-1.00.4-0.50.3-0.6
Progressive ratio test 1 active lever presses0.40.40.8-0.8-0.20.9-0.6-0.60.50.6-0.40.40.7-0.6-0.4-0.90.9-0.90.9-0.1-0.60.6-0.80.4
Progressive ratio test 1 breakpoint0.80.81.2-1.0-0.31.1-0.9-0.90.80.8-0.80.81.1-0.9-0.7-1.11.1-1.11.10.0-0.90.9-0.90.7
Progressive ratio test 1 inactive lever presses0.40.42.3-0.1-0.60.10.30.3-0.1-0.20.2-0.20.1-0.00.50.9-0.90.8-0.8-1.50.6-0.71.0-1.2
Progressive ratio test 2 active lever presses0.10.10.5-0.4-0.30.3-0.2-0.20.30.3-0.20.20.4-0.5-0.1-0.10.10.0-0.0-0.4-0.20.20.7-0.1
Progressive ratio test 2 breakpoint0.10.10.3-0.5-0.40.5-0.2-0.20.30.3-0.30.30.5-0.6-0.2-0.40.4-0.30.3-0.3-0.40.40.50.1
Progressive ratio test 2 inactive lever presses0.60.74.3-0.8-1.30.90.20.2-0.00.10.1-0.10.1-0.20.20.3-0.30.2-0.2-2.10.6-0.61.9-1.4
Incentive Sensitization - Responses0.30.34.3-0.3-0.60.30.30.3-0.2-0.10.2-0.2-0.2-0.00.20.1-0.10.2-0.2-0.60.4-0.42.1-0.6
Incentive Sensitization - Breakpoint0.30.34.6-0.5-0.70.50.20.2-0.10.00.1-0.1-0.0-0.20.0-0.20.20.0-0.0-0.70.3-0.32.2-0.6
Sum of active levers in priming session hrs 5-61.41.43.31.21.1-1.11.21.2-1.2-1.11.2-1.2-1.11.11.41.0-1.01.1-1.1-0.91.1-1.1-1.8-1.2
Progressive ratio1.92.23.31.71.4-1.51.41.4-1.6-1.61.7-1.7-1.81.81.61.1-1.11.2-1.2-0.51.7-1.7-0.7-1.5
Food seeking constrained by brief footshock0.60.83.60.71.8-0.70.70.7-0.7-0.40.8-0.8-0.70.70.5-0.20.2-0.30.31.9-0.10.1-1.81.0
Seeking ratio, punishment vs. effort2.43.05.3-1.8-0.91.6-1.5-1.51.61.9-1.71.71.8-1.9-1.8-1.71.7-1.81.81.6-2.12.1-0.42.3
Retroperitoneal fat weight9.531.144.6-6.2-6.56.1-6.7-6.76.66.2-6.46.46.3-6.1-5.8-5.05.0-4.94.9-1.3-5.35.32.43.3
Reaction time number correct2.63.75.62.10.9-1.91.91.9-2.0-2.21.9-1.9-1.92.02.12.1-2.12.1-2.1-0.92.4-2.4-1.0-1.9
Reaction time mean minus median2.02.64.2-1.9-2.11.9-1.9-1.91.81.9-1.81.81.7-1.7-1.7-1.61.6-1.61.6-1.0-1.21.21.00.5
Reaction time mean minus median AUC1.41.94.3-1.6-2.11.6-1.6-1.61.61.6-1.61.61.5-1.4-1.4-1.21.2-1.21.2-1.0-0.80.80.90.1
Reaction time num false alarms1.82.53.81.81.9-1.81.91.9-1.9-1.91.9-1.9-1.81.81.51.4-1.41.2-1.20.21.3-1.3-0.3-1.1
Reaction time num false alarms AUC1.52.13.11.71.7-1.71.81.8-1.7-1.71.7-1.7-1.71.61.31.4-1.41.1-1.10.31.1-1.1-0.6-0.9
Reaction time trials correct on left2.63.75.62.10.9-1.91.91.9-2.0-2.21.9-1.9-1.92.02.12.1-2.12.1-2.1-0.92.4-2.4-1.0-1.9
Reaction time trials on left2.63.75.72.00.8-1.91.81.8-2.0-2.11.8-1.8-1.91.92.12.1-2.12.1-2.1-0.92.4-2.4-0.8-2.0
Reaction time mean2.94.06.6-2.5-2.62.4-2.4-2.42.22.4-2.22.22.2-2.1-2.0-1.81.8-1.61.6-1.1-1.71.61.50.6
Reaction time mean AUC2.63.55.4-2.3-2.22.3-2.1-2.12.02.2-2.02.01.9-1.9-1.9-1.91.9-1.81.8-0.8-1.61.61.50.7
Median of all reaction times2.43.35.5-2.3-2.32.2-2.2-2.22.02.2-2.02.02.0-2.0-1.8-1.61.6-1.41.4-0.9-1.61.61.40.6
Reaction time omissions0.60.82.2-1.0-1.51.1-1.0-1.01.00.9-1.01.00.9-0.8-0.7-0.50.5-0.70.7-0.7-0.20.21.5-0.1
Reaction time false alarm rate0.20.31.20.51.1-0.60.80.8-0.6-0.60.8-0.8-0.70.60.30.4-0.40.1-0.10.40.1-0.10.2-0.1
Reaction time premature initiation rate0.10.20.40.40.0-0.30.10.1-0.4-0.40.4-0.4-0.40.10.50.5-0.50.6-0.6-0.50.3-0.2-0.1-0.6
Reaction time premature initiations1.31.92.71.50.6-1.41.11.1-1.4-1.61.4-1.4-1.41.21.61.6-1.61.6-1.6-0.91.4-1.4-0.8-1.6
Std. dev. reaction times2.33.24.8-2.1-2.22.0-2.1-2.12.02.1-2.02.01.9-1.8-1.7-1.61.6-1.51.5-1.0-1.41.41.90.5
Reaction time trials completed2.63.75.72.00.8-1.91.81.8-2.0-2.11.8-1.8-1.91.92.12.1-2.12.1-2.1-0.92.4-2.4-0.8-2.0
Reaction time trials AUC2.94.26.62.10.8-1.91.91.9-2.1-2.21.9-1.9-2.02.02.22.4-2.42.3-2.3-1.32.6-2.6-0.6-2.3
Run reversals in cocaine runway, females2.12.03.1-1.7-1.81.7-1.4-1.41.51.6-1.41.41.3-1.7-1.6-1.61.6-1.61.60.1-1.11.10.80.9
Run reversals in cocaine runway, males2.92.84.2-1.1-1.11.0-2.0-2.01.81.6-1.81.81.7-1.8-2.1-1.51.5-1.81.81.1-2.02.0-0.51.9
Latency to leave start box in cocaine runway0.80.91.70.20.6-0.11.21.2-1.2-1.01.3-1.3-1.21.30.6-0.20.2-0.10.1-1.01.2-1.20.8-1.3
Latency to leave start box in cocaine runway, F0.50.52.60.2-0.2-0.10.40.4-0.6-0.60.7-0.7-0.80.70.30.4-0.40.4-0.4-1.60.9-0.90.5-1.4
Latency to leave start box in cocaine runway, M0.80.82.2-0.41.10.41.01.0-0.9-0.50.9-0.9-0.70.90.1-1.51.5-1.11.10.70.2-0.21.10.2
Std. dev. time between licks in bursts0.81.01.51.21.0-1.21.01.0-1.0-1.21.0-1.0-0.90.91.01.1-1.11.1-1.10.90.9-0.90.6-0.4
Total sessions with >9 infusions0.80.91.8-1.1-1.11.1-1.0-1.01.01.0-0.90.91.0-1.0-0.7-1.01.0-1.31.3-0.1-0.70.7-0.00.5
Short access day 1 total inactive lever presses2.12.36.00.8-0.2-0.71.51.5-1.4-1.21.4-1.4-1.31.11.31.7-1.71.7-1.7-2.22.1-2.10.8-2.4
Short access day 10 total inactive lever presses0.40.42.4-0.4-1.00.4-0.0-0.00.30.3-0.40.40.3-0.3-0.20.7-0.70.6-0.6-1.10.6-0.61.6-0.9
Short access day 1 total infusions0.70.71.40.70.2-0.50.80.8-0.9-0.70.9-0.9-0.80.91.00.6-0.60.7-0.7-1.01.1-1.2-0.9-1.2
Short access day 10 total infusions0.20.21.2-0.4-0.30.5-0.2-0.20.20.3-0.10.10.3-0.3-0.2-0.40.4-0.60.6-0.5-0.00.0-1.1-0.2
Short access total infusions0.40.40.9-0.8-0.90.9-0.5-0.50.50.6-0.40.40.6-0.6-0.5-1.01.0-0.90.9-0.4-0.20.2-0.80.0
Short access day 1 locomotion0.50.51.1-0.9-1.01.0-0.2-0.20.60.8-0.60.60.8-0.7-0.7-1.01.0-1.01.00.0-0.20.2-0.40.3
Short access day 10 total locomotion0.40.40.90.70.9-0.80.60.6-0.6-0.50.5-0.5-0.40.51.00.9-0.90.9-0.90.40.4-0.4-0.3-0.2
Short access total locomotion0.60.61.7-0.50.00.5-0.3-0.30.40.6-0.40.40.6-0.6-0.5-1.21.2-1.31.31.3-0.60.6-0.81.1
One hour access (0.3 mA shock)0.20.30.4-0.00.50.00.70.7-0.6-0.30.6-0.6-0.40.40.60.5-0.50.4-0.4-0.40.6-0.7-0.0-0.6
Compulsive drug intake1.11.11.60.71.0-0.71.11.1-1.0-0.91.1-1.1-1.21.31.10.9-0.91.1-1.1-0.21.3-1.31.2-1.0
One hour access (shock baseline)0.30.41.0-0.8-0.70.7-0.6-0.60.60.6-0.70.70.9-1.0-0.7-0.20.2-0.50.5-0.2-0.60.6-0.30.4
Social response proportion4.34.66.9-2.5-2.22.6-1.9-1.92.22.4-2.22.22.3-2.2-2.4-2.62.6-2.62.60.3-1.91.9-0.11.4
Social responses0.10.20.6-0.1-0.40.1-0.4-0.40.40.3-0.50.50.5-0.5-0.4-0.30.3-0.20.20.3-0.40.4-0.80.3
Social time0.91.21.8-1.0-1.01.1-1.3-1.31.11.1-1.11.11.1-1.1-1.3-1.31.3-1.21.20.6-1.01.0-0.71.1
Soleus weight0.10.22.2-0.2-0.50.1-0.3-0.30.20.1-0.10.10.2-0.20.10.4-0.40.6-0.6-0.60.2-0.21.5-0.4
Bone: stiffness0.20.33.6-0.1-0.40.1-0.3-0.3-0.0-0.1-0.10.1-0.00.00.10.6-0.60.3-0.3-1.00.4-0.41.9-0.5
Tibialis anterior weight0.72.44.6-1.8-2.21.8-1.8-1.82.01.8-1.81.81.9-1.8-1.4-0.90.9-0.90.9-0.4-1.31.31.50.8
Time to tail flick, vehicle, before self-admin1.21.27.6-1.5-1.51.6-0.5-0.50.50.7-0.50.50.4-0.4-0.5-0.70.7-0.80.8-2.80.1-0.12.1-1.3
Time to tail flick, vehicle, after self-admin0.90.92.51.51.2-1.60.50.5-0.6-1.00.7-0.7-0.70.70.81.4-1.41.5-1.5-0.30.2-0.2-0.3-0.5
Time to tail flick, test, before self-admin0.20.20.70.40.6-0.40.30.3-0.3-0.20.3-0.3-0.30.30.90.6-0.60.6-0.6-0.40.2-0.2-0.4-0.4
Time to tail flick, test, after self-admin2.42.56.50.80.2-0.81.21.2-1.2-1.31.2-1.2-1.21.21.32.0-2.01.9-1.9-2.51.9-1.91.2-2.5
Delta time to tail flick, vehicle, before/after SA2.52.46.22.41.7-2.51.01.0-1.0-1.61.1-1.1-1.01.01.42.3-2.32.4-2.40.90.7-0.6-0.7-0.2
Delta time to tail flick, test, before/after SA1.00.92.70.3-0.0-0.30.70.7-0.7-0.80.8-0.8-0.80.80.51.1-1.10.9-0.9-1.31.2-1.31.6-1.5
Tibia length2.05.57.2-2.6-2.32.6-2.7-2.72.62.6-2.52.52.5-2.6-2.4-2.32.3-2.52.5-0.5-2.52.50.21.3
Ambulatory time before self-admin0.40.41.0-0.5-0.50.5-0.7-0.70.80.8-0.80.80.7-0.7-0.5-0.50.5-0.40.4-0.1-0.90.9-1.00.6
Ambulatory time after self-admin0.60.75.00.20.1-0.2-0.3-0.30.30.3-0.40.40.3-0.3-0.6-0.80.8-0.70.72.0-0.50.5-2.21.4
Bone: tissue strength1.51.42.2-1.4-1.21.3-1.4-1.41.31.5-1.31.31.4-1.4-1.1-1.11.1-1.01.00.5-1.21.20.21.0
Total heroin consumption1.01.23.10.30.2-0.21.31.3-1.3-0.91.3-1.3-1.21.11.20.3-0.30.4-0.4-1.61.5-1.50.7-1.8
Bone: trabecular number0.20.43.40.20.7-0.30.50.5-0.6-0.60.6-0.6-0.50.40.40.2-0.20.2-0.20.80.4-0.41.9-0.2
Bone: trabecular spacing1.31.73.5-0.9-1.10.9-1.6-1.61.41.3-1.51.51.5-1.5-1.4-1.11.1-1.11.1-0.5-1.51.5-1.91.0
Bone: trabecular thickness0.10.11.70.00.3-0.10.30.3-0.3-0.20.2-0.2-0.20.20.30.2-0.20.3-0.30.40.2-0.21.3-0.1
Bone: trabecular tissue density0.91.32.4-1.0-0.60.9-1.4-1.41.31.3-1.31.31.2-1.2-1.2-0.80.8-1.11.10.9-1.21.30.21.5
Water consumed over 24 hours0.20.32.3-0.4-0.50.4-0.0-0.0-0.1-0.00.2-0.2-0.20.10.20.4-0.40.4-0.4-1.50.5-0.50.9-1.1
Number of responses in last shaping day0.90.92.50.8-0.1-0.90.50.5-0.6-0.60.6-0.6-0.50.60.91.5-1.51.6-1.6-1.31.0-1.0-0.1-1.3