Hub : Traits

ShA early average infusions

Mean number of infusions over days 1-3 of short access

Tags: Behavior · Cocaine

Project: u01_olivier_george_cocaine

5 loci · 5 genes with independent associations · 5 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	106304569	107278380	1	1	1.57e-07	1.14e-03	2.56e-10	Tsg101
2	chr7	92127461	93066096	1	1	1.35e-11	6.47e-01	1.00e+00	Ndufb9
3	chr8	117463629	118343328	1	1	1.93e-10	1.56e-01	1.00e+00	Mst1
4	chr9	83390749	84777604	1	1	0.00e+00	4.56e-01	1.00e+00	Retreg2
5	chr17	61510864	62906219	1	1	7.87e-14	4.02e-02	1.25e-02	Ccny

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	439.52	2	2	40	0	1.00e+00	Ndufb9 Retreg2
BMI without tail	14316.61	4	2	40	-1	1.70e-04	Ccny Ndufb9 Retreg2 Tsg101
Body weight	7.09	4	2	40	-0.22	7.79e-01	Mst1 Ndufb9 Retreg2 Tsg101
Epididymis fat weight	9080.51	4	3	60	-1	5.64e-04	Ccny Mst1 Ndufb9 Retreg2
Glucose	226.07	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Heart weight	1536.76	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Left kidney weight	18352.54	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Right kidney weight	10109.45	4	4	80	1	4.74e-04	Ccny Mst1 Ndufb9 Retreg2
Tail length	14460.63	2	1	20	0	1.00e+00	Mst1 Retreg2
Length with tail	501.6	3	3	60	0	1.00e+00	Mst1 Ndufb9 Retreg2
Length without tail	11815.62	4	2	40	1	2.80e-04	Ccny Mst1 Ndufb9 Retreg2
Liver weight, left	880.75	4	2	40	1	4.71e-03	Ccny Mst1 Ndufb9 Retreg2
Liver weight, right	31.51	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Parametrial fat weight	181.56	1	1	20	0	1.00e+00	Retreg2
Retroperitoneal fat weight	1985.63	2	2	40	0	1.00e+00	Mst1 Retreg2
Intraocular pressure	10386.52	1	1	20	0	1.00e+00	Retreg2
Extensor digitorum longus weight	541.05	2	1	20	0	1.00e+00	Mst1 Retreg2
Soleus weight	9.26	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Tibialis anterior weight	580.28	2	1	20	0	1.00e+00	Mst1 Retreg2
Tibia length	265.42	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Number of licking bursts	67424.86	1	1	20	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	11843.69	3	1	20	0	1.00e+00	Ccny Mst1 Retreg2
Times rat made contact with spout	41.61	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean time between licks in bursts	55817.09	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean num. licks in bursts	56750.08	1	1	20	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	14881.26	2	1	20	0	1.00e+00	Mst1 Retreg2
Water consumed over 24 hours	11394.32	3	1	20	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging indifference point 0 sec	19591.07	2	1	20	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	12566.41	4	3	60	1	2.24e-04	Ccny Mst1 Ndufb9 Retreg2
Indifference point function ln k	13972.7	4	4	80	-1	3.08e-04	Ccny Mst1 Ndufb9 Retreg2
Indifference point function log k	13972.7	4	4	80	-1	3.08e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	20977.37	2	1	20	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	612.51	4	4	80	-1	5.29e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	10122.69	4	2	40	-1	9.93e-05	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	18737.98	4	3	60	-1	3.08e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	1956.8	4	2	40	-1	1.65e-04	Ccny Mst1 Ndufb9 Retreg2
Patch foraging time to switch 0 sec	22171.85	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 0 sec	30219.01	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	23555.93	3	2	40	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging water rate 18 sec	11246.65	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 24 sec	523.92	2	1	20	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	225.66	4	3	60	0.97	2.75e-02	Ccny Ndufb9 Retreg2 Tsg101
Locomotor activity	22	2	1	20	0	1.00e+00	Ccny Mst1
Locomotor testing distance	6934.02	4	3	60	1	2.01e-03	Ccny Mst1 Ndufb9 Retreg2
Locomotor testing rearing	21145.02	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Light reinforcement 1	22114.5	3	2	40	0	1.00e+00	Ccny Mst1 Retreg2
Light reinforcement 2	9210.73	4	3	60	1	1.57e-03	Ccny Mst1 Ndufb9 Retreg2
Reaction time number correct	21165.65	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean minus median	39986.09	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time mean minus median AUC	41341.25	3	3	60	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time num false alarms	7685.9	2	1	20	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	11677.34	3	1	20	0	1.00e+00	Ccny Mst1 Retreg2
Reaction time trials correct on left	21165.65	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials on left	20303.42	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean	29724.21	1	1	20	0	1.00e+00	Retreg2
Reaction time mean AUC	38768	1	1	20	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	20	0	1.00e+00	Retreg2
Reaction time omissions	2792.39	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time false alarm rate	76.38	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time premature initiation rate	9733.76	1	1	20	0	1.00e+00	Retreg2
Reaction time premature initiations	53743.58	1	1	20	0	1.00e+00	Retreg2
Std. dev. reaction times	20293.6	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time trials completed	20303.42	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials AUC	20718.27	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Social response proportion	4397.95	2	1	20	0	1.00e+00	Mst1 Retreg2
Social responses	323.05	4	1	20	1	7.32e-04	Ccny Mst1 Ndufb9 Retreg2
Social time	5828.31	2	1	20	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	1400.08	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	20	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	20	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	40	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	7271.32	2	2	40	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	14360.59	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	1165.18	2	2	40	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	5466.41	2	2	40	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1311.07	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	243.91	2	1	20	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	1278.33	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	19909.31	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	6407.33	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	17558.57	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	40	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	25214.4	4	2	40	-1	1.98e-04	Ccny Ndufb9 Retreg2 Tsg101
Conditioned reinforcement - inactives	16265.43	4	3	60	-1	2.20e-03	Ccny Mst1 Ndufb9 Retreg2
Conditioned locomotion	2608.24	4	2	40	-1	1.08e-03	Ccny Mst1 Ndufb9 Retreg2
Intermittent access intake day 1-15 change	31975.02	4	2	40	-1	6.10e-05	Ccny Mst1 Retreg2 Tsg101
Intermittent access intake escalation	42028.98	3	2	40	0	1.00e+00	Mst1 Retreg2 Tsg101
Intermittent access intake escalation 2	9055.39	4	2	40	-1	3.12e-04	Ccny Mst1 Retreg2 Tsg101
Intermitt. access day 1 inactive lever presses	45173.91	4	2	40	-1	2.94e-04	Ccny Mst1 Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses	61868.22	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access escalation Index	23354.91	4	2	40	1	2.24e-04	Mst1 Ndufb9 Retreg2 Tsg101
Intermittent access day 1 total infusions	33063.01	2	1	20	0	1.00e+00	Mst1 Retreg2
Intermittent access day 15 total infusions	24368.95	2	1	20	0	1.00e+00	Retreg2 Tsg101
Intermittent access terminal intake (last 3 days)	12403.01	2	1	20	0	1.00e+00	Retreg2 Tsg101
Intermittent access total infusions	93.49	2	1	20	0	1.00e+00	Ccny Retreg2
Intermittent access day 1 locomotion	17487.55	2	1	20	0	1.00e+00	Ccny Retreg2
Intermittent access day 15 total locomotion	42786.58	2	2	40	0	1.00e+00	Ccny Retreg2
Intermittent access total locomotion	45.91	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Intermittent access standard deviation	28504.05	4	3	60	-1	4.52e-04	Ccny Mst1 Retreg2 Tsg101
Cocaine induced anxiety	23063.21	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Post-drug Anxiety	1595.89	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Baseline Anxiety	11242.19	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Lifetime Intake	834.23	2	1	20	0	1.00e+00	Ccny Retreg2
Incentive Sensitization - Responses	23798.01	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Incentive Sensitization - Breakpoint	18436.14	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 active lever presses	10671	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	10109.49	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	20756.82	3	3	60	0	1.00e+00	Mst1 Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	5096.01	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 breakpoint	2856.35	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 inactive lever presses	14505.59	5	1	20	-1	5.63e-07	Ccny Mst1 Ndufb9 Retreg2 Tsg101
Total sessions with >9 infusions	678.23	3	3	60	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 1 total inactive lever presses	9884.94	4	3	60	1	1.91e-03	Ccny Mst1 Ndufb9 Retreg2
Short access day 10 total inactive lever presses	34738.22	4	3	60	-1	7.86e-04	Ccny Mst1 Retreg2 Tsg101
Short access day 1 total infusions	12825.11	3	2	40	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 10 total infusions	7585.44	3	3	60	0	1.00e+00	Mst1 Ndufb9 Retreg2
Short access total infusions	2937.55	3	2	40	0	1.00e+00	Ccny Retreg2 Tsg101
Short access day 1 locomotion	6216.13	4	2	40	-1	1.34e-03	Ccny Mst1 Ndufb9 Retreg2
Short access day 10 total locomotion	44094.34	2	1	20	0	1.00e+00	Mst1 Retreg2
Short access total locomotion	6239.96	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Compulsive drug intake	6234.79	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
One hour access (0.3 mA shock)	781.33	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
One hour access (shock baseline)	54988.81	1	1	20	0	1.00e+00	Retreg2
Number of responses in last shaping day	4550.18	3	1	20	0	1.00e+00	Ccny Mst1 Retreg2
Context. condit. distance diff. score	212.47	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 1	1769.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	516.6	2	1	20	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 2	1110.36	2	2	40	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	174.93	3	1	20	0	1.00e+00	Ccny Mst1 Retreg2
Locomotion velocity, session 3	507.49	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	20	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	20	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	40	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	342.68	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	1279.33	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	1081.37	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	409.23	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	40	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	690.43	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	1569.87	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Incentive salience index mean	1780.77	2	1	20	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	2666.81	2	2	40	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	5593.23	2	1	20	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	40	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	221.7	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	2966.16	2	2	40	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	40	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	28.15	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Total locomotion distance, hab. session 2	14.23	2	1	20	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	20	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	7678.6	2	1	20	0	1.00e+00	Mst1 Retreg2
Novelty place preference	7474.7	2	1	20	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	5350.34	2	1	20	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	980.79	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	1687.31	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	479.14	2	1	20	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever latency	186.46	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. change in total contacts	522.83	2	1	20	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. index score	214.07	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	224.45	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	252.4	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	250.94	2	1	20	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	60.1	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	223.77	2	2	40	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	303.26	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: apparent density	2735.95	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone surface	3109.3	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone volume	4317.38	2	1	20	0	1.00e+00	Mst1 Retreg2
Bone: connectivity density	564.06	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical apparent density	6014.36	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical area	1559.21	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	150.35	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	560.57	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	119.31	4	2	40	0.85	1.48e-01	Mst1 Ndufb9 Retreg2 Tsg101
Bone: cortical thickness	996.09	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical tissue density	4339.01	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: elastic displacement	7604.03	1	1	20	0	1.00e+00	Retreg2
Bone: elastic work	195.81	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	2975.35	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: endosteal perimeter	5936.33	2	1	20	0	1.00e+00	Mst1 Retreg2
Bone: final force	840.18	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: final moment	146.88	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	3148.45	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum diameter	2046.98	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum force	4390.32	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	2024.32	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: minimum diameter	2061.38	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	4919.52	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: periosteal perimeter	5722.93	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: post-yield work	6843.13	2	1	20	0	1.00e+00	Mst1 Retreg2
Bone: stiffness	4554.23	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	2995.95	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular number	5387.39	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular spacing	2669.39	3	3	60	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: trabecular thickness	4257.4	2	2	40	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	4866.8	3	3	60	0	1.00e+00	Mst1 Ndufb9 Retreg2
LgA early post infusion interval	13357.35	4	3	60	1	8.91e-04	Ccny Ndufb9 Retreg2 Tsg101
LgA late post infusion interval	11653.15	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
LgA early loading	36381.47	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Tsg101
LgA late loading	46428.54	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
LgA early average infusions	7311.62	4	1	20	-1	1.69e-04	Ccny Ndufb9 Retreg2 Tsg101
LgA late average infusions	31550.62	2	2	40	0	1.00e+00	Ndufb9 Retreg2
LgA early timeout	12057.77	1	1	20	0	1.00e+00	Retreg2
LgA late timeout	29424.99	2	1	20	0	1.00e+00	Ndufb9 Retreg2
LgA early titration	20830.18	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Tsg101
LgA late titration	16928.3	4	3	60	-1	8.70e-04	Mst1 Ndufb9 Retreg2 Tsg101
LgA total infusion	13538.04	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
LgA PC1 addiction-like behavior	52579.61	2	2	40	0	1.00e+00	Ndufb9 Retreg2
ShA PR total presses	11213.89	2	1	20	0	1.00e+00	Ndufb9 Retreg2
LgA PR total presses	3281.01	2	2	40	0	1.00e+00	Ccny Retreg2
ShA early post infusion interval	4052.33	2	2	40	0	1.00e+00	Retreg2 Tsg101
ShA late post infusion interval	74.52	5	1	20	0.88	4.92e-02	Ccny Mst1 Ndufb9 Retreg2 Tsg101
ShA early loading	51.13	5	3	60	0.99	1.03e-03	Ccny Mst1 Ndufb9 Retreg2 Tsg101
ShA late loading	18923.13	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Tsg101
ShA late average infusions	2964.91	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Tsg101
ShA early timeout	132.52	5	3	60	0.99	1.79e-03	Ccny Mst1 Ndufb9 Retreg2 Tsg101
ShA late timeout	6149.51	3	1	20	0	1.00e+00	Mst1 Retreg2 Tsg101
ShA early titration	320.18	5	4	80	1	2.34e-04	Ccny Mst1 Ndufb9 Retreg2 Tsg101
ShA late titration	3826.49	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
ShA total infusions	12431.66	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Tsg101
Shock compulsivity	58902.44	2	2	40	0	1.00e+00	Ccny Retreg2
Total infusions	7200.41	4	2	40	-1	4.37e-04	Ccny Ndufb9 Retreg2 Tsg101
Breakpoint value in progressive ratio session	18809.48	2	1	20	0	1.00e+00	Mst1 Retreg2
Distance traveled before self-admin	12640.31	4	1	20	-1	2.27e-04	Ccny Mst1 Ndufb9 Retreg2
Distance traveled after self-admin	16247.09	2	2	40	0	1.00e+00	Ccny Retreg2
Delta time in closed arm before/after self-admin	98.8	4	2	40	-0.86	1.44e-01	Ccny Mst1 Ndufb9 Retreg2
Delta time in open arm before/after self-admin	3791.66	4	1	20	-1	1.88e-03	Ccny Mst1 Retreg2 Tsg101
Diff in mean of infusions in LGA sessions	12226.72	3	2	40	0	1.00e+00	Mst1 Ndufb9 Retreg2
Extinction: sum of active levers before priming	7131.77	4	4	80	-1	1.09e-04	Ccny Mst1 Ndufb9 Retreg2
Active lever presses in extinction session 6	272.24	3	3	60	0	1.00e+00	Ccny Mst1 Retreg2
Delta distance traveled before/after self-admin	996.98	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	10288.96	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Time in closed arm before self-admin	8974	3	2	40	0	1.00e+00	Ccny Mst1 Retreg2
Time in closed arm after self-admin	1181.81	4	3	60	-0.98	1.76e-02	Ccny Mst1 Retreg2 Tsg101
Time in open arm before self-admin	2213.9	4	3	60	0.99	8.47e-03	Ccny Mst1 Ndufb9 Retreg2
Time in open arm after self-admin	126.56	5	3	60	-0.85	6.56e-02	Ccny Mst1 Ndufb9 Retreg2 Tsg101
Sum of active levers in priming session hrs 5-6	496.26	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Time to tail flick, vehicle, before self-admin	3376.29	4	3	60	-1	9.05e-04	Ccny Mst1 Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin	14057.72	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Time to tail flick, test, before self-admin	2050.84	4	2	40	1	4.54e-03	Mst1 Ndufb9 Retreg2 Tsg101
Time to tail flick, test, after self-admin	377.49	4	2	40	-0.95	4.69e-02	Ccny Mst1 Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	3305.45	3	3	60	0	1.00e+00	Ccny Mst1 Retreg2
Delta time to tail flick, test, before/after SA	5236.1	3	1	20	0	1.00e+00	Mst1 Ndufb9 Retreg2
Ambulatory time before self-admin	39445.74	2	1	20	0	1.00e+00	Ccny Retreg2
Ambulatory time after self-admin	8880.01	3	1	20	0	1.00e+00	Ccny Mst1 Retreg2
Total heroin consumption	134.58	2	2	40	0	1.00e+00	Ccny Retreg2
Area under the delay curve	24791.27	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	10986.22	2	1	20	0	1.00e+00	Ccny Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	10821.07	3	1	20	0	1.00e+00	Ccny Retreg2 Tsg101
Delay disc. indifference point, 4s delay	162.94	4	1	20	1	5.63e-04	Ccny Mst1 Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	20	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	20	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	20	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	20	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	1437.89	4	3	60	-1	2.95e-04	Ccny Ndufb9 Retreg2 Tsg101
Time >=10cm from walls, locomotor time 1	4342.59	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Bouts of movement, locomotor time 1	3607.99	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Total resting periods, locomotor time 1	1407.78	2	1	20	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 1	11183.83	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 1	22964.53	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Vertical activity count, locomotor time 1	142354.07	1	1	20	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	35582.77	2	1	20	0	1.00e+00	Ccny Retreg2
Bouts of movement, locomotor time 2	41025.7	2	2	40	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 2	49531.53	2	2	40	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 2	8507.09	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Tsg101
Distance moved, locomotor task time 2	2839.58	3	2	40	0	1.00e+00	Ccny Retreg2 Tsg101
Vertical activity count, locomotor time 2	17860.02	3	1	20	0	1.00e+00	Ccny Retreg2 Tsg101
Weight adjusted by age	23619.48	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock	4493.27	3	1	20	0	1.00e+00	Ccny Retreg2 Tsg101
Locomotion in novel chamber	1330.8	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	21811.49	3	1	20	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio	22651.13	3	3	60	0	1.00e+00	Ccny Ndufb9 Retreg2
Food seeking constrained by brief footshock	630.78	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Tsg101
Seeking ratio, punishment vs. effort	13770.59	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	20	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	3884.61	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway	8153.9	2	1	20	0	1.00e+00	Ccny Retreg2
Latency to leave start box in cocaine runway, F	3596.44	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	593.09	3	2	40	0	1.00e+00	Ccny Ndufb9 Retreg2
Co content in liver	1133.25	1	1	20	0	1.00e+00	Retreg2
Cu content in liver	28.08	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Fe content in liver	1344.53	1	1	20	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	20	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	20	0	1.00e+00	Retreg2
Mn content in liver	537.3	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Na content in liver	2013.84	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Rb content in liver	71.08	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Se content in liver	8.63	1	0	0	0	1.00e+00	Ndufb9
Zn content in liver	1887.46	2	2	40	0	1.00e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.12
Adipose	alternative TSS	0	0	1.11
Adipose	gene expression	0	0	1.09
Adipose	isoform ratio	0	0	1.1
Adipose	intron excision ratio	0	0	0.98
Adipose	mRNA stability	1	0	1.08
BLA	alternative polyA	0	0	1.11
BLA	alternative TSS	0	0	1.05
BLA	gene expression	0	0	1.09
BLA	isoform ratio	0	0	1.02
BLA	intron excision ratio	0	0	1.02
BLA	mRNA stability	0	0	1.09
Brain	alternative polyA	0	0	1.12
Brain	alternative TSS	0	0	1.07
Brain	gene expression	0	0	1.1
Brain	isoform ratio	1	0	1.1
Brain	intron excision ratio	0	0	1.04
Brain	mRNA stability	0	0	1.1
Eye	alternative polyA	0	0	1.23
Eye	alternative TSS	0	0	0.94
Eye	gene expression	0	0	0.99
Eye	isoform ratio	0	0	1.1
Eye	intron excision ratio	0	0	0.99
Eye	mRNA stability	0	0	1.14
IC	alternative polyA	0	0	1.07
IC	alternative TSS	0	0	1.06
IC	gene expression	0	0	1.14
IC	isoform ratio	0	0	1.11
IC	intron excision ratio	0	0	1.05
IC	mRNA stability	0	0	1.13
IL	alternative polyA	0	0	0.97
IL	alternative TSS	0	0	1.02
IL	gene expression	0	0	1.1
IL	isoform ratio	0	0	1.06
IL	intron excision ratio	0	0	0.93
IL	mRNA stability	0	0	1.07
LHb	alternative polyA	0	0	1.11
LHb	alternative TSS	0	0	1.12
LHb	gene expression	0	0	1.05
LHb	isoform ratio	0	0	1.1
LHb	intron excision ratio	0	0	1.04
LHb	mRNA stability	0	0	1.14
Liver	alternative polyA	0	0	1.12
Liver	alternative TSS	0	0	1.09
Liver	gene expression	0	0	1.11
Liver	isoform ratio	1	0	1.1
Liver	intron excision ratio	0	0	1.13
Liver	mRNA stability	0	0	1.08
NAcc	alternative polyA	1	0	7.55
NAcc	alternative TSS	0	0	1.04
NAcc	gene expression	0	0	1.12
NAcc	isoform ratio	0	0	1.13
NAcc	intron excision ratio	0	0	1.05
NAcc	mRNA stability	0	0	1.1
OFC	alternative polyA	0	0	1.16
OFC	alternative TSS	0	0	1
OFC	gene expression	0	0	1.11
OFC	isoform ratio	0	0	1.09
OFC	intron excision ratio	0	0	1
OFC	mRNA stability	0	0	1.1
PL	alternative polyA	0	0	1.13
PL	alternative TSS	0	0	1.06
PL	gene expression	0	0	1.1
PL	isoform ratio	0	0	1.08
PL	intron excision ratio	0	0	1.02
PL	mRNA stability	0	0	1.13
pVTA	alternative polyA	0	0	1.15
pVTA	alternative TSS	0	0	1.12
pVTA	gene expression	1	0	1.12
pVTA	isoform ratio	0	0	1.11
pVTA	intron excision ratio	0	0	1.04
pVTA	mRNA stability	0	0	1.14
RMTg	alternative polyA	0	0	1.01
RMTg	alternative TSS	0	0	1.28
RMTg	gene expression	0	0	1.08
RMTg	isoform ratio	0	0	0.99
RMTg	intron excision ratio	0	0	0.93
RMTg	mRNA stability	0	0	1.13