Hub : Genes

Ccny

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Ccny	0.12	0.08	5.9e-04	0.02	0.02	0.02	0.02	6.2e-03	4.3e-03	4.2e-03	1.4e-02
2	Adipose	mRNA stability	Ccny	0.02	0.02	9.2e-03	0	0.01	0	0.01	8.1e-02	2.6e-02	9.2e-02	4.2e-02
3	PL	gene expression	Ccny	0.08	0.07	2.2e-05	0.05	0.04	0.05	0.04	6.4e-06	2.9e-05	9.0e-06	2.6e-05
4	NAcc	gene expression	Ccny	0.11	0.07	4.9e-06	0.03	0.03	0.03	0.04	8.3e-06	9.2e-06	7.1e-06	3.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.3	5.2	2.3	-0.1	0.2	-0.3
Area under the delay curve	4.0	6.1	24.2	4.9	-0.3	0.4	-0.4
BMI with tail	0.5	1.8	6.4	-2.5	0.5	-0.6	0.3
BMI without tail	4.9	25.9	100.1	10.0	-1.1	1.2	-1.0
Body weight	1.3	5.6	8.6	1.4	-2.9	2.6	-2.2
Weight adjusted by age	20.3	59.4	234.4	15.3	-0.8	1.4	-0.9
Bone surface	1.7	3.3	4.8	0.9	-1.9	2.0	-2.2
Bone volume	1.4	2.7	3.2	1.8	-1.5	1.6	-1.6
Breakpoint value in progressive ratio session	3.7	6.7	26.3	-5.1	0.2	-0.5	0.3
Number of licking bursts	0.8	2.5	9.7	3.1	0.2	-0.2	0.3
Context. condit. distance diff. score	2.0	2.4	6.8	-2.6	1.1	-1.1	0.8
Locomotion velocity, session 1	1.8	2.1	6.5	-2.5	1.0	-0.8	0.4
Locomotion distance, session 1	5.0	6.3	12.6	3.5	2.1	-2.0	2.1
Locomotion velocity, session 2	0.1	0.1	0.2	0.1	0.2	0.1	-0.5
Locomotion distance, session 2	5.7	8.0	27.0	5.2	1.4	-1.3	1.3
Locomotion velocity, session 3	0.3	0.3	0.6	0.5	0.8	-0.6	0.1
Locomotion distance, session 3	0.6	0.6	2.3	-1.5	0.2	-0.1	-0.4
Stereotopy head waving bouts, day 3	1.6	2.0	2.8	0.5	-1.7	1.6	-1.4
Stereotopy head waving duration, day 3	1.7	2.1	2.6	-1.6	-1.4	1.4	-1.4
Locomotion velocity, session 7	1.1	1.2	3.9	2.0	0.6	-0.6	0.6
Locomotion distance, session 7	0.8	1.0	1.4	0.2	1.2	-1.2	1.0
Stereotopy head waving bouts, day 7	1.3	1.5	2.3	0.4	-1.3	1.4	-1.5
Stereotopy head waving duration, day 7	1.1	1.4	1.9	0.8	-1.2	1.3	-1.4
Locomotion velocity, session 8	2.1	2.6	9.4	-3.1	0.7	-0.5	0.0
Locomotion distance, session 8	1.8	2.6	2.8	1.7	1.7	-1.6	1.5
Degree of sensitization distance	1.4	1.5	4.0	2.0	0.7	-0.8	1.0
Degree of sensitization stereotypy	1.3	1.4	2.1	0.5	-1.3	1.3	-1.4
Conditioned locomotion	3.7	4.4	17.5	-4.2	-0.1	0.0	0.1
Cocaine response after cond. corrected	3.6	5.4	20.7	-4.6	0.5	-0.5	0.4
Cocaine response after cond. not corrected	1.3	1.8	7.3	-2.7	-0.1	0.1	-0.1
Cocaine response before conditioning	5.0	6.0	21.2	4.6	-1.1	1.1	-0.8
Saline control response	0.7	0.9	1.0	1.0	-1.0	1.0	-0.8
Bone: connectivity density	0.3	0.5	1.0	1.0	-0.4	0.5	-0.8
Bone: cortical apparent density	1.3	2.0	7.9	2.8	-0.3	0.2	0.2
Bone: cortical area	0.0	0.1	0.1	0.3	0.3	-0.2	0.2
Bone: cortical porosity	2.6	2.8	5.1	-2.3	-1.4	1.4	-1.5
Bone: cortical porosity	2.0	2.2	4.4	-2.1	-1.3	1.2	-1.2
Bone: cortical thickness	0.4	0.6	0.9	-0.0	1.0	-0.9	0.8
Bone: cortical thickness	0.1	0.1	0.2	0.5	-0.0	0.1	-0.3
Bone: cortical tissue density	1.4	2.2	8.6	2.9	-0.4	0.3	0.1
Condit. Reinf. active minus inactive responses	4.2	4.8	13.5	3.7	-1.2	1.3	-1.6
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	-0.3	-0.8	0.7	-1.0
Condit. Reinf. active responses	5.8	7.4	17.2	4.1	-1.9	2.1	-2.2
Condit. Reinf. inactive responses	1.1	1.4	2.0	0.5	-1.3	1.4	-1.3
Incentive salience index mean	4.8	6.2	16.6	4.1	-1.6	1.6	-1.7
Condit. Reinf. lever presses	1.9	2.9	6.6	2.6	-1.4	1.3	-1.1
Condit. Reinf. active minus inactive responses	0.9	1.3	2.2	-1.0	-0.9	1.1	-1.5
Condit. Reinf. active-inactive response ratio	1.0	1.6	5.0	-2.2	-0.4	0.6	-1.1
Condit. Reinf. active responses	1.6	2.2	3.3	0.8	-1.5	1.7	-1.8
Condit. Reinf. inactive responses	2.4	3.5	8.7	3.0	-1.4	1.4	-1.2
Condit. Reinf. lever presses	1.3	1.9	6.4	2.5	0.8	-0.6	0.4
Condit. Reinf. lever reinforcers received	0.9	1.3	1.9	0.5	-1.1	1.3	-1.4
Conditioned reinforcement - actives	3.5	14.1	54.6	-7.4	-0.7	0.8	-0.7
Conditioned reinforcement - inactives	4.7	12.9	50.6	-7.1	0.5	-0.9	0.1
Conditioned locomotion	31.1	46.2	180.9	-13.4	0.9	-1.3	1.2
Patch foraging indifference point 0 sec	0.3	0.8	1.5	0.6	0.8	-0.9	1.2
Patch foraging indifference point AUC	18.2	43.4	173.1	13.2	-0.3	0.5	-0.5
Delay disc. indifference point, 0s delay	1.6	1.9	7.0	2.6	-0.4	0.5	-0.3
Delay disc. indifference point, 16s delay	18.1	25.6	100.6	10.0	-0.5	1.0	-0.7
Delay disc. indifference point, 2s delay	1.8	2.0	7.9	2.8	0.3	-0.0	-0.2
Delay disc. indifference point, 24s delay	16.6	26.5	105.8	10.3	-0.2	0.4	-0.3
Delay disc. indifference point, 4s delay	17.7	18.8	75.1	-8.7	0.1	-0.1	0.2
Delay disc. indifference point, 8s delay	0.4	0.7	1.6	1.3	-0.7	0.5	-0.8
Indifference point function ln k	17.6	53.3	211.1	-14.5	0.8	-1.0	0.6
Indifference point function log k	17.6	53.3	211.1	-14.5	0.8	-1.0	0.6
Patch foraging total patch changes 0 sec	0.3	0.9	1.8	0.1	0.9	-1.0	1.3
Patch foraging total patch changes 12 sec	39.2	52.5	209.6	14.5	0.4	-0.2	0.5
Patch foraging total patch changes 18 sec	2.0	4.7	17.4	4.2	0.5	-0.6	0.9
Patch foraging total patch changes 24 sec	5.0	17.1	68.3	8.3	-0.1	0.3	0.1
Patch foraging total patch changes 6 sec	16.6	28.0	110.2	10.5	0.8	-0.6	0.9
Patch foraging time to switch 0 sec	0.4	1.4	2.2	0.7	-1.4	1.5	-1.0
Patch foraging water rate 0 sec	0.1	0.2	0.3	-0.3	0.5	-0.6	0.4
Patch foraging water rate 12 sec	12.2	49.1	194.4	13.9	0.9	-0.6	0.9
Patch foraging water rate 18 sec	1.7	3.7	13.8	-3.7	-0.6	0.4	-0.8
Patch foraging water rate 24 sec	6.3	8.9	32.0	-5.7	0.9	-1.1	1.3
Patch foraging water rate 6 sec	25.7	37.9	151.1	-12.3	0.2	-0.5	0.3
Seeking ratio, delayed vs. immediate footshock	6.4	9.1	32.3	-5.7	-0.9	1.1	-1.5
Distance traveled before self-admin	16.2	35.3	139.1	11.8	-0.4	1.1	-0.9
Distance traveled after self-admin	29.6	52.1	207.9	14.4	0.4	0.5	0.2
Extensor digitorum longus weight	0.5	1.9	2.4	1.1	-1.4	1.4	-1.6
Bone: elastic displacement	0.3	0.3	1.2	1.1	-0.0	-0.1	0.3
Bone: elastic work	1.2	1.6	3.0	-1.7	1.1	-1.1	0.9
Bone: endosteal estimation	0.9	2.1	2.8	0.6	-1.7	1.7	-1.6
Bone: endosteal perimeter	0.5	1.3	2.0	1.4	-1.1	1.1	-1.0
Epididymis fat weight	16.4	83.0	316.3	17.8	-2.6	2.4	-1.8
Delta time in closed arm before/after self-admin	198.9	186.7	740.6	27.2	-0.9	1.5	-1.8
Delta time in open arm before/after self-admin	18.9	22.3	85.0	-9.2	1.0	-1.3	1.3
Diff in mean of infusions in LGA sessions	0.8	1.5	3.2	-1.8	0.9	-0.5	1.2
Delay discount exponential model param	1.3	1.8	7.0	-2.7	0.3	-0.3	0.3
Extinction: sum of active levers before priming	44.5	67.5	267.9	16.4	-0.6	1.0	-0.9
Active lever presses in extinction session 6	57.2	57.5	230.0	15.2	0.1	0.3	0.1
Bone: final force	1.6	2.6	3.7	1.9	1.5	-1.5	1.4
Bone: final moment	1.4	2.2	4.2	2.0	1.3	-1.2	1.2
Food consumed during 24 hour testing period	4.6	9.2	23.9	4.9	2.2	-2.1	1.9
Glucose	0.1	0.2	0.4	-0.2	0.5	-0.4	0.6
Heart weight	4.9	7.8	30.3	5.5	0.9	-0.4	0.2
Delay discount hyperbolic model param	0.2	0.3	1.0	-1.0	0.1	-0.2	0.3
Intermittent access intake day 1-15 change	1.8	10.1	39.9	6.3	0.6	-0.3	0.3
Intermittent access intake escalation	0.3	1.5	5.3	2.3	0.6	-0.3	0.3
Intermittent access intake escalation 2	26.4	44.4	177.3	-13.3	0.3	-0.3	0.3
Intermitt. access day 1 inactive lever presses	0.8	9.9	18.1	4.3	2.6	-2.8	2.6
Intermitt. access day 15 inactive lever presses	0.3	1.9	5.5	2.3	0.9	-0.9	0.6
Intermitt. access escalation Index	1.9	5.9	23.4	-4.8	0.0	-0.1	0.4
Intermittent access day 1 total infusions	1.1	3.4	13.3	-3.6	0.0	0.0	-0.4
Intermittent access day 15 total infusions	2.4	6.0	23.6	4.9	0.4	0.0	-0.3
Intermittent access terminal intake (last 3 days)	1.3	2.2	8.0	2.8	-0.3	0.4	-0.8
Intermittent access total infusions	4.0	4.7	18.6	-4.3	0.0	0.1	-0.5
Intermittent access day 1 locomotion	9.2	17.0	65.1	8.1	1.2	-1.0	0.6
Intermittent access day 15 total locomotion	14.8	57.2	227.4	15.1	0.9	-0.6	0.2
Intermittent access total locomotion	1.6	1.9	4.8	2.2	1.2	-1.0	0.6
Intermittent access standard deviation	13.1	68.5	272.3	-16.5	0.5	-0.9	0.9
Left kidney weight	0.7	6.0	18.8	-4.3	-1.4	1.1	-1.4
Right kidney weight	4.1	28.8	112.8	-10.6	-1.0	0.7	-1.0
Cocaine induced anxiety	4.8	13.0	51.6	-7.2	-0.5	-0.1	-0.3
Post-drug Anxiety	1.2	1.4	2.7	-0.7	-1.7	1.0	-1.1
Baseline Anxiety	17.0	28.5	113.3	10.6	-0.5	0.5	-0.2
Tail length	5.9	31.6	82.9	9.1	-4.1	4.0	-3.3
Length with tail	3.6	16.1	24.0	1.9	-4.9	4.7	-3.8
Length without tail	5.8	30.4	109.1	-10.4	-2.4	2.0	-1.7
Times rat made contact with spout	0.2	0.2	0.6	-0.8	0.3	-0.2	0.2
Lifetime Intake	11.2	13.9	55.5	-7.4	-0.0	0.1	-0.5
Liver weight, left	4.6	7.9	28.7	-5.4	-1.0	1.0	-0.8
Liver weight, right	1.7	3.0	11.9	-3.5	0.1	-0.0	0.1
Locomotor activity	14.8	23.2	90.2	9.5	1.0	-0.9	0.9
Locomotor testing distance	27.1	66.6	266.1	16.3	0.5	-0.2	0.3
Locomotor testing rearing	0.0	0.0	0.1	-0.1	0.2	-0.1	0.1
Locomotion in novel chamber	5.2	7.0	27.7	-5.3	0.6	-0.2	0.1
Locomotion in novel chamber post-restriction	1.7	5.3	20.9	-4.6	0.4	-0.2	-0.2
Fecal boli incidents, locomotor time 1	2.1	5.6	22.0	-4.7	0.2	-0.1	-0.4
Change in fecal boli incidents, locomotor task	40.7	43.2	170.8	13.1	0.8	-0.5	1.0
Time >=10cm from walls, locomotor time 1	13.8	17.2	68.6	8.3	-0.0	0.1	-0.2
Bouts of movement, locomotor time 1	24.7	32.0	121.9	-11.0	-1.7	1.2	-1.3
Total resting periods, locomotor time 1	18.8	21.7	81.7	-9.0	-1.5	1.1	-1.2
Rest time, locomotor task time 1	4.3	6.9	24.5	4.9	-1.0	1.0	-1.1
Distance moved, locomotor task time 1	5.3	15.0	56.6	-7.5	1.1	-0.9	1.2
Vertical activity count, locomotor time 1	0.0	0.2	0.3	-0.5	0.6	-0.4	0.4
Time >=10cm from walls, locomotor time 2	1.5	4.4	12.9	3.6	1.1	-1.4	1.2
Bouts of movement, locomotor time 2	8.8	29.1	103.1	-10.2	-2.4	1.8	-2.0
Total resting periods, locomotor time 2	6.6	26.8	93.7	-9.7	-2.5	1.9	-2.0
Rest time, locomotor task time 2	6.7	11.3	39.2	6.3	-1.4	1.6	-1.2
Distance moved, locomotor task time 2	42.1	55.9	220.2	-14.8	0.9	-1.2	1.1
Vertical activity count, locomotor time 2	15.6	36.4	144.9	-12.0	0.3	-0.7	-0.0
Light reinforcement 1	24.2	109.7	435.9	-20.9	0.6	-1.2	1.1
Light reinforcement 2	35.8	80.8	321.5	-17.9	0.7	-1.0	0.4
Bone: marrow area	0.9	2.3	3.0	0.8	-1.7	1.7	-1.6
Bone: maximum diameter	0.5	1.1	1.3	0.8	-1.1	1.1	-1.2
Bone: maximum force	0.6	1.2	1.8	0.3	1.3	-1.3	1.1
Bone: maximum moment	0.4	0.8	1.2	0.4	1.1	-1.1	0.9
Mean time between licks in bursts	0.9	5.3	14.3	3.8	-1.6	1.5	-1.5
Mean num. licks in bursts	1.2	3.3	12.9	-3.6	-0.2	0.2	-0.3
Cd content in liver	2.3	2.6	3.9	0.4	1.8	-1.8	2.0
Co content in liver	1.4	1.6	2.2	0.1	1.4	-1.5	1.5
Cu content in liver	1.4	1.7	2.1	1.0	-1.5	1.4	-1.3
Fe content in liver	2.2	2.7	3.7	0.8	-1.9	1.9	-1.7
K content in liver	1.9	1.9	2.1	1.4	-1.5	1.4	-1.2
Mg content in liver	2.3	2.5	3.2	0.9	-1.8	1.8	-1.7
Mn content in liver	2.9	3.3	4.7	0.1	-2.0	2.1	-2.2
Na content in liver	0.4	0.4	1.6	1.3	-0.1	0.1	0.1
Rb content in liver	0.3	0.4	0.5	-0.1	-0.7	0.7	-0.7
Se content in liver	3.1	3.7	4.9	0.8	-2.2	2.2	-2.1
Sr content in liver	0.1	0.1	0.3	-0.5	0.2	-0.1	-0.0
Zn content in liver	0.6	0.7	0.9	0.6	-0.9	0.9	-0.8
Bone: minimum diameter	0.1	0.1	0.6	0.8	-0.1	0.1	0.1
Time in familiar zone, hab. session 1	1.0	1.1	1.6	-0.3	-1.1	1.3	-1.2
Time in novel zone, hab. session 1	1.2	1.4	1.8	-1.3	1.1	-1.2	1.1
Total zone transitions, hab. session 1	2.9	4.0	4.6	2.1	2.0	-2.0	1.9
Total locomotion distance, hab. session 1	2.9	4.2	16.6	4.1	-0.0	-0.0	0.2
Locomotion velocity, hab. session 1	2.9	4.1	16.5	4.1	-0.1	0.0	0.2
Time in familiar zone, hab. session 2	0.4	0.5	0.8	-0.3	0.9	-0.8	0.7
Time in novel zone, hab. session 2	0.1	0.1	0.4	0.6	-0.1	0.1	-0.2
Total zone transitions, hab. session 2	2.4	3.1	5.2	2.3	1.5	-1.5	1.6
Total locomotion distance, hab. session 2	2.1	2.7	9.2	3.0	-0.9	0.8	-0.5
Locomotion velocity, hab. session 2	3.0	4.0	13.8	3.7	-1.0	0.9	-0.6
Novel to familiar place preference ratio	2.9	3.8	14.3	3.8	0.4	-0.4	0.7
Novelty place preference	2.0	2.5	9.6	3.1	0.3	-0.3	0.6
Time in novel zone, NPP test	1.4	1.7	6.6	2.6	0.2	-0.3	0.5
Total zone transitions, NPP test	1.1	1.6	5.2	2.3	0.6	-0.6	0.7
Total locomotion distance, NPP test	5.4	7.5	27.4	5.2	-1.1	1.0	-0.7
Locomotion velocity, NPP test	5.9	8.4	31.8	5.6	-0.9	0.8	-0.5
Intraocular pressure	0.7	1.2	2.7	0.4	1.0	-0.9	1.7
Delta distance traveled before/after self-admin	38.9	42.8	166.0	-12.9	1.2	-1.2	1.5
Delta ambulatory time before/after self-admin	18.3	31.6	120.9	-11.0	1.2	-1.1	1.7
Parametrial fat weight	2.3	5.5	18.4	4.3	-1.3	1.0	-1.0
Pavlov. Cond. lever latency	1.8	2.2	3.0	0.4	1.7	-1.7	1.7
Pavlov. Cond. magazine entry latency	3.3	4.3	10.3	3.2	-1.7	1.6	-1.2
Pavlov. Cond. change in total contacts	4.3	4.7	8.3	2.9	-2.0	1.9	-1.6
Pavlov. Cond. index score	1.5	1.9	2.3	1.2	-1.5	1.4	-1.3
Pavlov. Cond. latency score	2.0	2.5	2.9	1.5	-1.7	1.6	-1.5
Pavlov. Cond. lever contacts	1.4	1.6	2.3	-0.4	-1.5	1.5	-1.4
Pavlov. Cond. magazine entry number	3.5	4.4	13.8	-3.7	1.3	-1.2	0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.5	-0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	2.0	1.4	-1.4	1.3	-1.1
Pavlov. Cond. response bias	1.7	2.1	3.2	1.8	-1.5	1.4	-1.1
Pavlov. Cond. lever latency	1.1	1.5	4.1	-2.0	-1.0	0.8	-0.5
Pavlov. Cond. magazine entry latency	2.5	3.6	13.4	3.7	0.5	-0.5	0.6
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.6	0.4	-0.4	0.5
Pavlov. Cond. index score	2.2	3.5	13.7	3.7	0.4	-0.3	0.2
Pavlov. Cond. latency score	2.2	3.6	14.1	3.8	0.4	-0.2	0.2
Pavlov. Cond. lever contacts	0.8	1.2	1.8	1.1	1.3	-1.2	0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.5	-0.5	0.5	-0.7
Pavlov. Cond. intertrial magazine entries	0.6	1.4	4.9	-2.2	-0.3	0.3	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.2	8.8	3.0	0.3	-0.2	0.2
Pavlov. Cond. response bias	2.0	2.7	6.3	2.5	1.4	-1.3	1.0
Time in closed arm before self-admin	13.2	22.9	82.4	-9.1	1.6	-1.4	2.1
Time in closed arm after self-admin	82.9	94.1	375.2	19.4	-0.0	1.1	-0.1
Time in open arm before self-admin	36.2	44.1	174.4	13.2	-0.7	0.9	-1.0
Time in open arm after self-admin	17.7	19.5	77.1	-8.8	0.2	-0.9	0.1
Bone: periosteal estimation	0.5	1.3	1.7	0.5	-1.2	1.3	-1.3
Bone: periosteal perimeter	0.2	0.4	0.5	0.2	-0.7	0.7	-0.7
Bone: post-yield work	0.0	0.1	0.3	0.5	0.2	-0.1	-0.0
Progressive ratio test 1 active lever presses	15.0	26.4	105.4	-10.3	-0.1	0.1	-0.5
Progressive ratio test 1 breakpoint	14.0	24.0	96.0	-9.8	-0.0	0.0	-0.4
Progressive ratio test 1 inactive lever presses	3.5	9.1	32.7	-5.7	1.1	-1.4	0.8
Progressive ratio test 2 active lever presses	11.9	16.8	62.9	-7.9	-1.2	0.9	-1.4
Progressive ratio test 2 breakpoint	16.7	21.4	82.0	-9.1	-1.1	0.8	-1.3
Progressive ratio test 2 inactive lever presses	4.2	13.4	53.7	-7.3	0.0	-0.3	-0.1
Incentive Sensitization - Responses	4.4	12.2	43.6	-6.6	-1.5	1.1	-1.2
Incentive Sensitization - Breakpoint	5.0	11.3	40.9	-6.4	-1.4	1.0	-1.2
Sum of active levers in priming session hrs 5-6	1.3	1.2	1.9	1.2	0.9	-1.4	0.9
Progressive ratio	13.9	40.9	162.4	-12.7	0.6	-0.8	0.3
Food seeking constrained by brief footshock	1.9	2.4	4.1	-1.5	-2.0	1.4	-1.1
Seeking ratio, punishment vs. effort	4.7	10.5	35.5	6.0	-1.8	1.5	-0.9
Retroperitoneal fat weight	0.3	1.5	2.8	1.3	-1.7	1.0	-0.7
Reaction time number correct	7.7	27.1	107.2	-10.4	0.5	-0.8	0.6
Reaction time mean minus median	0.7	4.6	17.9	-4.2	-0.5	0.3	0.4
Reaction time mean minus median AUC	0.1	0.5	1.3	1.1	-0.6	0.5	-0.1
Reaction time num false alarms	10.7	18.2	66.3	-8.1	1.5	-1.6	1.3
Reaction time num false alarms AUC	9.2	21.2	79.1	-8.9	1.3	-1.5	1.3
Reaction time trials correct on left	7.7	27.1	107.2	-10.4	0.5	-0.8	0.6
Reaction time trials on left	10.1	34.2	135.5	-11.6	0.5	-0.8	0.6
Reaction time mean	1.8	3.9	9.6	-3.1	1.1	-1.4	1.7
Reaction time mean AUC	2.1	5.0	17.0	-4.1	0.6	-1.0	1.3
Median of all reaction times	2.0	3.1	3.5	-1.8	1.5	-1.8	1.9
Reaction time omissions	0.8	1.3	4.2	-2.0	-0.8	0.4	-0.5
Reaction time false alarm rate	0.8	1.1	2.7	-1.6	0.8	-0.8	0.7
Reaction time premature initiation rate	2.8	4.3	13.3	3.7	-1.3	1.3	-0.8
Reaction time premature initiations	1.5	4.6	17.3	-4.2	-0.8	0.6	-0.4
Std. dev. reaction times	0.6	2.0	6.3	-2.5	0.2	-0.5	1.1
Reaction time trials completed	10.1	34.2	135.5	-11.6	0.5	-0.8	0.6
Reaction time trials AUC	10.6	36.9	145.9	-12.1	0.6	-0.9	0.7
Run reversals in cocaine runway, females	7.4	8.3	25.1	5.0	-1.7	1.6	-1.6
Run reversals in cocaine runway, males	5.7	6.3	25.1	-5.0	0.1	-0.3	0.3
Latency to leave start box in cocaine runway	14.9	20.5	81.6	-9.0	-0.0	-0.5	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.4	-0.3	-0.1	-0.5
Latency to leave start box in cocaine runway, M	53.0	50.6	200.8	-14.2	0.6	-1.0	0.2
Std. dev. time between licks in bursts	0.5	1.0	1.6	-0.6	-1.3	1.1	-1.0
Total sessions with >9 infusions	22.8	28.3	112.8	-10.6	0.5	-0.4	0.2
Short access day 1 total inactive lever presses	5.0	10.0	29.6	5.4	1.9	-2.0	1.6
Short access day 10 total inactive lever presses	27.1	186.6	739.0	-27.2	0.9	-1.8	1.9
Short access day 1 total infusions	63.2	125.1	500.3	-22.4	-0.2	0.0	-0.2
Short access day 10 total infusions	1.8	2.9	11.5	-3.4	0.3	-0.2	-0.1
Short access total infusions	26.7	37.8	150.7	-12.3	-0.3	0.3	-0.5
Short access day 1 locomotion	13.7	22.8	89.4	-9.5	0.8	-0.8	0.6
Short access day 10 total locomotion	2.9	11.7	43.2	-6.6	1.0	-1.1	1.2
Short access total locomotion	1.6	2.5	6.6	2.6	1.2	-1.1	0.8
One hour access (0.3 mA shock)	12.3	14.6	56.8	-7.5	0.6	-0.8	0.7
Compulsive drug intake	3.5	5.1	13.7	3.7	-1.5	1.7	-1.3
One hour access (shock baseline)	2.3	5.9	21.3	4.6	0.9	-1.0	0.7
Social response proportion	0.9	1.1	4.4	-2.1	-0.1	-0.0	-0.1
Social responses	7.7	10.1	40.4	6.4	-0.1	0.2	-0.1
Social time	2.0	3.1	7.5	-2.7	1.5	-1.4	1.0
Soleus weight	0.7	2.1	7.7	-2.8	0.5	-0.5	0.4
Bone: stiffness	0.8	1.4	3.6	1.9	0.8	-0.8	0.9
Tibialis anterior weight	0.1	0.5	0.8	-0.2	0.9	-0.8	0.6
Time to tail flick, vehicle, before self-admin	132.6	163.3	648.8	25.5	-0.7	1.8	-0.8
Time to tail flick, vehicle, after self-admin	8.0	16.3	63.6	-8.0	-0.5	0.9	-0.6
Time to tail flick, test, before self-admin	5.2	5.9	20.7	4.6	-1.0	1.4	-0.2
Time to tail flick, test, after self-admin	42.5	44.9	169.1	13.0	-1.8	2.3	-1.5
Delta time to tail flick, vehicle, before/after SA	91.9	98.2	390.3	-19.8	0.9	-1.2	0.7
Delta time to tail flick, test, before/after SA	4.1	5.1	19.0	4.4	-0.6	0.4	-1.0
Tibia length	1.3	3.7	4.3	1.4	-2.0	2.1	-2.1
Ambulatory time before self-admin	16.5	50.2	199.7	14.1	-0.1	0.9	-0.5
Ambulatory time after self-admin	19.2	30.7	122.2	11.1	0.3	0.6	0.1
Bone: tissue strength	0.9	1.0	1.5	0.2	1.1	-1.1	1.2
Total heroin consumption	33.4	39.3	156.4	12.5	0.6	-0.2	0.6
Bone: trabecular number	0.0	0.0	0.1	0.3	0.0	0.1	-0.2
Bone: trabecular spacing	0.1	0.2	0.5	0.7	0.2	-0.3	0.5
Bone: trabecular thickness	1.2	1.6	5.3	2.3	-0.7	0.7	-0.6
Bone: trabecular tissue density	4.8	8.4	32.4	-5.7	0.3	-0.6	0.8
Water consumed over 24 hours	3.6	7.0	25.9	5.1	0.9	-0.9	0.9
Number of responses in last shaping day	31.3	40.5	161.4	12.7	0.7	-0.2	0.1