Hub : Traits

LgA PC1 addiction-like behavior

First PC for all traits from long access

Tags: Behavior · Cocaine

Project: u01_olivier_george_cocaine

5 loci · 5 genes with independent associations · 6 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr2	144588926	145970994	1	1	6.20e-09	3.61e-02	1.00e+00	Clrn1
2	chr3	89562573	90958818	1	1	5.56e-10	8.59e-03	1.18e-13	Serping1
3	chr3	186761232	188108974	1	1	1.15e-08	2.49e-03	3.72e-02	Taf4
4	chr7	92127461	93066096	1	1	1.72e-23	1.73e-02	1.00e+00	Ndufb9
5	chr9	83390749	84777604	2	1	0.00e+00	3.76e-01	1.00e+00	Retreg2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	294.06	3	2	40	0	1.00e+00	Clrn1 Ndufb9 Retreg2
BMI without tail	11457.68	4	2	40	1	1.50e-06	Clrn1 Ndufb9 Retreg2 Serping1
Body weight	8.77	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Epididymis fat weight	12098.28	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Glucose	273.97	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Heart weight	1027.64	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Serping1
Left kidney weight	18355.52	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Right kidney weight	13472.97	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Tail length	9645.98	2	1	20	0	1.00e+00	Retreg2 Serping1
Length with tail	499.12	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Length without tail	15749.56	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Liver weight, left	1747.19	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Liver weight, right	26.54	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Parametrial fat weight	181.56	1	1	20	0	1.00e+00	Retreg2
Retroperitoneal fat weight	1315.5	2	1	20	0	1.00e+00	Clrn1 Retreg2
Intraocular pressure	5196.88	1	1	20	0	1.00e+00	Retreg2
Extensor digitorum longus weight	1077.67	1	1	20	0	1.00e+00	Retreg2
Soleus weight	12.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Tibialis anterior weight	1158.38	1	1	20	0	1.00e+00	Retreg2
Tibia length	385.43	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Number of licking bursts	22481.66	2	1	20	0	1.00e+00	Retreg2 Serping1
Food consumed during 24 hour testing period	17758.05	1	1	20	0	1.00e+00	Retreg2
Times rat made contact with spout	41.61	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean time between licks in bursts	37213.79	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Mean num. licks in bursts	18923.26	2	1	20	0	1.00e+00	Retreg2 Serping1
Std. dev. time between licks in bursts	29750.31	1	1	20	0	1.00e+00	Retreg2
Water consumed over 24 hours	11394.82	2	1	20	0	1.00e+00	Clrn1 Retreg2
Patch foraging indifference point 0 sec	39171.5	1	1	20	0	1.00e+00	Retreg2
Patch foraging indifference point AUC	12540.67	3	1	20	-1	4.10e-06	Clrn1 Ndufb9 Retreg2
Indifference point function ln k	13930.82	3	2	40	1	3.16e-05	Clrn1 Ndufb9 Retreg2
Indifference point function log k	13930.82	3	2	40	1	3.16e-05	Clrn1 Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	41947.04	1	1	20	0	1.00e+00	Retreg2
Patch foraging total patch changes 12 sec	1174.88	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	13490.44	3	1	20	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	24967.63	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	3903.01	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging time to switch 0 sec	22175.26	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 0 sec	20149.67	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	35328.83	1	1	20	0	1.00e+00	Retreg2
Patch foraging water rate 18 sec	11246.17	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 24 sec	1033.47	1	1	20	0	1.00e+00	Retreg2
Patch foraging water rate 6 sec	435.09	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Locomotor testing distance	9230.7	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Locomotor testing rearing	21144.27	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Light reinforcement 1	16585.84	3	1	20	-1	2.24e-05	Retreg2 Serping1 Taf4
Light reinforcement 2	12251.59	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time number correct	21167.41	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time mean minus median	29996.4	3	1	20	1	3.06e-04	Clrn1 Ndufb9 Retreg2
Reaction time mean minus median AUC	31009.11	3	2	40	1	4.17e-04	Clrn1 Ndufb9 Retreg2
Reaction time num false alarms	15357.42	1	1	20	0	1.00e+00	Retreg2
Reaction time num false alarms AUC	17511.01	1	1	20	0	1.00e+00	Retreg2
Reaction time trials correct on left	21167.41	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time trials on left	20304.09	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time mean	9918.61	2	2	40	0	1.00e+00	Clrn1 Retreg2
Reaction time mean AUC	12933.5	2	2	40	0	1.00e+00	Clrn1 Retreg2
Median of all reaction times	2639.46	2	1	20	0	1.00e+00	Clrn1 Retreg2
Reaction time omissions	2792.53	3	1	20	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Reaction time false alarm rate	108.16	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Reaction time premature initiation rate	9733.76	1	1	20	0	1.00e+00	Retreg2
Reaction time premature initiations	26876.79	1	1	20	0	1.00e+00	Retreg2
Std. dev. reaction times	15225.4	3	1	20	1	4.38e-04	Clrn1 Ndufb9 Retreg2
Reaction time trials completed	20304.09	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Reaction time trials AUC	20718.6	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Social response proportion	8777.03	1	1	20	0	1.00e+00	Retreg2
Social responses	428.13	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Serping1
Social time	5827.82	2	1	20	0	1.00e+00	Retreg2 Serping1
Conditioned locomotion	1400.08	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	9573.48	1	1	20	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	9294.65	1	1	20	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	20	0	1.00e+00	Retreg2
Saline control response	3160.68	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active minus inactive responses	14521.56	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	9577.12	3	1	20	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Condit. Reinf. active responses	2302.04	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	10889.7	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	1935.17	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	469.54	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	2531.81	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry latency	13282.18	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	13274.44	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	12744.53	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	16150.81	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	5331.08	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. magazine entry number	4012.39	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	17498.16	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever-magazine prob. diff.	11800.43	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	1164.95	1	1	20	0	1.00e+00	Retreg2
Conditioned reinforcement - actives	33618.78	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Conditioned reinforcement - inactives	21642.11	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Conditioned locomotion	5202.57	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Intermittent access intake day 1-15 change	63945.98	1	1	20	0	1.00e+00	Retreg2
Intermittent access intake escalation	63041.97	1	1	20	0	1.00e+00	Retreg2
Intermittent access intake escalation 2	36175.43	1	1	20	0	1.00e+00	Retreg2
Intermitt. access day 1 inactive lever presses	60216.77	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses	41255.98	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access escalation Index	23332.43	3	1	20	-1	5.03e-04	Clrn1 Ndufb9 Retreg2
Intermittent access day 1 total infusions	33065.11	1	1	20	0	1.00e+00	Retreg2
Intermittent access day 15 total infusions	24368.74	1	1	20	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	24800.59	1	1	20	0	1.00e+00	Retreg2
Intermittent access total infusions	93.95	2	1	20	0	1.00e+00	Clrn1 Retreg2
Intermittent access day 1 locomotion	17486.48	1	1	20	0	1.00e+00	Retreg2
Intermittent access day 15 total locomotion	42779.17	1	1	20	0	1.00e+00	Retreg2
Intermittent access total locomotion	64.05	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Intermittent access standard deviation	56990.22	1	1	20	0	1.00e+00	Retreg2
Cocaine induced anxiety	23066.22	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Post-drug Anxiety	2390.18	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Baseline Anxiety	16852.64	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Lifetime Intake	831.22	2	1	20	0	1.00e+00	Clrn1 Retreg2
Incentive Sensitization - Responses	23802.44	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Incentive Sensitization - Breakpoint	18439.14	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Progressive ratio test 1 active lever presses	8001.66	3	1	20	1	2.91e-04	Clrn1 Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	7580.78	3	1	20	1	3.79e-04	Clrn1 Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	20749.71	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	5092.33	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Progressive ratio test 2 breakpoint	8542.35	1	1	20	0	1.00e+00	Retreg2
Progressive ratio test 2 inactive lever presses	24174.12	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total sessions with >9 infusions	1959.63	1	1	20	0	1.00e+00	Retreg2
Short access day 1 total inactive lever presses	9862.76	3	2	40	-1	1.15e-03	Clrn1 Ndufb9 Retreg2
Short access day 10 total inactive lever presses	46292.14	2	1	20	0	1.00e+00	Clrn1 Retreg2
Short access day 1 total infusions	12801.18	2	1	20	0	1.00e+00	Clrn1 Retreg2
Short access day 10 total infusions	7575.7	3	2	40	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Short access total infusions	4392.25	2	1	20	0	1.00e+00	Clrn1 Retreg2
Short access day 1 locomotion	12422.14	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Short access day 10 total locomotion	44097.22	1	1	20	0	1.00e+00	Retreg2
Short access total locomotion	9343.18	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Compulsive drug intake	9346.2	2	1	20	0	1.00e+00	Ndufb9 Retreg2
One hour access (0.3 mA shock)	1167.82	2	1	20	0	1.00e+00	Ndufb9 Retreg2
One hour access (shock baseline)	18334.7	2	1	20	0	1.00e+00	Clrn1 Retreg2
Number of responses in last shaping day	4545.12	2	1	20	0	1.00e+00	Clrn1 Retreg2
Context. condit. distance diff. score	212.47	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 1	1769.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	1024.77	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 2	2158.08	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 2	508.11	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 3	507.49	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	1361.96	1	1	20	0	1.00e+00	Retreg2
Stereotopy head waving duration, day 3	2872.44	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, session 7	292.79	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 7	435.3	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	1279.33	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	1081.37	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	409.23	1	1	20	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization distance	3670.85	1	1	20	0	1.00e+00	Retreg2
Degree of sensitization stereotypy	1029.63	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	2347.53	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Incentive salience index mean	3540.72	1	1	20	0	1.00e+00	Retreg2
Condit. Reinf. lever presses	5282.33	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 1	5589.03	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 1	9232.79	1	1	20	0	1.00e+00	Retreg2
Total zone transitions, hab. session 1	221.7	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	20	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	5880.03	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, hab. session 2	6311.49	1	1	20	0	1.00e+00	Retreg2
Total zone transitions, hab. session 2	25.73	3	1	20	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Total locomotion distance, hab. session 2	22.17	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	20	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	15339.58	1	1	20	0	1.00e+00	Retreg2
Novelty place preference	14927.56	1	1	20	0	1.00e+00	Retreg2
Time in novel zone, NPP test	10685.62	1	1	20	0	1.00e+00	Retreg2
Total zone transitions, NPP test	980.79	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	1687.31	1	1	20	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	953.07	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever latency	491.79	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. change in total contacts	1037.76	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. index score	384.43	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. latency score	404.63	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. lever contacts	344.19	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	491.61	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. intertrial magazine entries	69.21	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	418.89	1	1	20	0	1.00e+00	Retreg2
Pavlov. Cond. response bias	583.93	1	1	20	0	1.00e+00	Retreg2
Bone: apparent density	2735.95	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone surface	6197.68	1	1	20	0	1.00e+00	Retreg2
Bone volume	8624.75	1	1	20	0	1.00e+00	Retreg2
Bone: connectivity density	841.82	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical apparent density	6014.36	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical area	2293.91	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical porosity	221.79	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical porosity	560.57	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	191.17	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	1464.97	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical tissue density	6505.97	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: elastic displacement	2539.18	2	1	20	0	1.00e+00	Clrn1 Retreg2
Bone: elastic work	184.45	2	1	20	0	1.00e+00	Clrn1 Retreg2
Bone: endosteal estimation	2974.59	3	1	20	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Bone: endosteal perimeter	11863.6	1	1	20	0	1.00e+00	Retreg2
Bone: final force	1600.36	1	1	20	0	1.00e+00	Retreg2
Bone: final moment	219.15	1	1	20	0	1.00e+00	Retreg2
Bone: marrow area	3147.04	3	1	20	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Bone: maximum diameter	3037.24	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Bone: maximum force	8697.09	1	1	20	0	1.00e+00	Retreg2
Bone: maximum moment	5989.29	1	1	20	0	1.00e+00	Retreg2
Bone: minimum diameter	4100.86	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal estimation	9791.57	1	1	20	0	1.00e+00	Retreg2
Bone: periosteal perimeter	11400.25	1	1	20	0	1.00e+00	Retreg2
Bone: post-yield work	13672.98	1	1	20	0	1.00e+00	Retreg2
Bone: stiffness	9032.86	1	1	20	0	1.00e+00	Retreg2
Bone: tissue strength	2995.95	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular number	5387.39	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular spacing	3988.39	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular thickness	8476.26	1	1	20	0	1.00e+00	Retreg2
Bone: trabecular tissue density	7288.68	2	2	40	0	1.00e+00	Ndufb9 Retreg2
LgA early post infusion interval	13355.48	3	2	40	-1	4.64e-05	Clrn1 Ndufb9 Retreg2
LgA late post infusion interval	8743.16	4	2	40	-1	5.60e-06	Clrn1 Ndufb9 Retreg2 Serping1
LgA early loading	21839.16	4	2	40	1	7.82e-07	Clrn1 Ndufb9 Retreg2 Serping1
LgA late loading	23221.63	5	2	40	1	4.20e-09	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
LgA early average infusions	4877.24	5	1	20	1	8.38e-09	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
LgA late average infusions	10525.33	5	3	60	1	4.52e-10	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
LgA early timeout	6034.29	2	1	20	0	1.00e+00	Clrn1 Retreg2
LgA late timeout	19623.28	2	1	20	0	1.00e+00	Ndufb9 Retreg2
LgA early titration	15627.26	3	2	40	1	3.96e-05	Ndufb9 Retreg2 Taf4
LgA late titration	13550.72	4	3	60	1	4.23e-07	Ndufb9 Retreg2 Serping1 Taf4
LgA total infusion	6778.08	5	4	80	1	3.07e-08	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
ShA PR total presses	5617.71	4	2	40	1	4.88e-04	Clrn1 Ndufb9 Retreg2 Taf4
LgA PR total presses	2171.4	3	1	20	0	1.00e+00	Clrn1 Retreg2 Serping1
ShA early post infusion interval	2698.31	3	1	20	0	1.00e+00	Clrn1 Retreg2 Serping1
ShA late post infusion interval	160.61	2	1	20	0	1.00e+00	Ndufb9 Retreg2
ShA early loading	64.7	3	2	40	0	1.00e+00	Clrn1 Ndufb9 Retreg2
ShA late loading	9468.73	5	1	20	1	1.84e-09	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
ShA early average infusions	6492.02	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Serping1
ShA late average infusions	1787.19	5	2	40	1	8.06e-05	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
ShA early timeout	182.64	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Serping1
ShA late timeout	9223.88	2	1	20	0	1.00e+00	Clrn1 Retreg2
ShA early titration	494.61	3	2	40	0	1.00e+00	Ndufb9 Retreg2 Serping1
ShA late titration	2300.79	5	1	20	1	1.74e-05	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
ShA total infusions	6220.83	5	2	40	1	2.18e-08	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
Shock compulsivity	39270.93	2	2	40	0	1.00e+00	Retreg2 Serping1
Total infusions	4809.28	5	3	60	1	2.81e-07	Clrn1 Ndufb9 Retreg2 Serping1 Taf4
Breakpoint value in progressive ratio session	12539.65	2	1	20	0	1.00e+00	Retreg2 Taf4
Distance traveled before self-admin	10114.93	4	1	20	1	9.60e-06	Clrn1 Ndufb9 Retreg2 Serping1
Distance traveled after self-admin	32464.08	1	1	20	0	1.00e+00	Retreg2
Delta time in closed arm before/after self-admin	126.6	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Delta time in open arm before/after self-admin	7571.82	1	1	20	0	1.00e+00	Retreg2
Diff in mean of infusions in LGA sessions	12222.37	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Extinction: sum of active levers before priming	14206.81	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Active lever presses in extinction session 6	373.78	2	1	20	0	1.00e+00	Retreg2 Taf4
Delta distance traveled before/after self-admin	748.2	3	2	40	-0.99	9.09e-03	Ndufb9 Retreg2 Serping1
Delta ambulatory time before/after self-admin	7726.43	3	2	40	-1	5.77e-04	Ndufb9 Retreg2 Serping1
Time in closed arm before self-admin	13438.92	2	1	20	0	1.00e+00	Retreg2 Serping1
Time in closed arm after self-admin	4591.18	1	1	20	0	1.00e+00	Retreg2
Time in open arm before self-admin	1769.53	4	2	40	-1	1.91e-04	Clrn1 Ndufb9 Retreg2 Serping1
Time in open arm after self-admin	261.21	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	253.01	4	1	20	0.97	2.67e-02	Ndufb9 Retreg2 Serping1 Taf4
Time to tail flick, vehicle, before self-admin	6687.6	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin	8458.37	4	2	40	1	1.64e-04	Ndufb9 Retreg2 Serping1 Taf4
Time to tail flick, test, before self-admin	4093.6	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Time to tail flick, test, after self-admin	739.72	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	3287.68	2	2	40	0	1.00e+00	Retreg2 Serping1
Delta time to tail flick, test, before/after SA	7848.65	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Ambulatory time before self-admin	19730.39	3	2	40	1	9.14e-04	Retreg2 Serping1 Taf4
Ambulatory time after self-admin	26614.91	1	1	20	0	1.00e+00	Retreg2
Total heroin consumption	86.03	3	1	20	0	1.00e+00	Clrn1 Retreg2 Taf4
Area under the delay curve	8269.89	2	1	20	0	1.00e+00	Clrn1 Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	21959.9	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	32437.06	1	1	20	0	1.00e+00	Retreg2
Delay disc. indifference point, 4s delay	315.77	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	16687.74	1	1	20	0	1.00e+00	Retreg2
Delay discount exponential model param	5646	2	1	20	0	1.00e+00	Clrn1 Retreg2
Delay discount hyperbolic model param	4097.91	2	1	20	0	1.00e+00	Clrn1 Retreg2
Fecal boli incidents, locomotor time 1	30605.7	1	1	20	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	2849.45	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	3257.7	3	1	20	-1	1.18e-04	Ndufb9 Retreg2 Serping1
Bouts of movement, locomotor time 1	10785.17	1	1	20	0	1.00e+00	Retreg2
Total resting periods, locomotor time 1	2793.59	1	1	20	0	1.00e+00	Retreg2
Rest time, locomotor task time 1	7459.87	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Serping1
Distance moved, locomotor task time 1	17230.24	3	3	60	-1	2.20e-05	Ndufb9 Retreg2 Serping1
Vertical activity count, locomotor time 1	47464.33	2	2	40	0	1.00e+00	Retreg2 Serping1
Time >=10cm from walls, locomotor time 2	23725.12	2	1	20	0	1.00e+00	Retreg2 Serping1
Bouts of movement, locomotor time 2	27350.17	2	1	20	0	1.00e+00	Retreg2 Serping1
Total resting periods, locomotor time 2	33022.39	2	1	20	0	1.00e+00	Retreg2 Serping1
Rest time, locomotor task time 2	8506.4	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 2	8477.87	1	1	20	0	1.00e+00	Retreg2
Vertical activity count, locomotor time 2	26782.26	2	1	20	0	1.00e+00	Retreg2 Serping1
Weight adjusted by age	17711.2	3	2	40	1	4.35e-05	Clrn1 Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock	13445.31	1	1	20	0	1.00e+00	Retreg2
Locomotion in novel chamber	1332.19	3	2	40	0	1.00e+00	Clrn1 Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	21812.77	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Progressive ratio	16986.92	3	2	40	-1	3.00e-05	Ndufb9 Retreg2 Serping1
Food seeking constrained by brief footshock	941.83	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Seeking ratio, punishment vs. effort	20653.58	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Run reversals in cocaine runway, females	4708.93	2	1	20	0	1.00e+00	Retreg2 Serping1
Run reversals in cocaine runway, males	3884.61	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway	16290.75	1	1	20	0	1.00e+00	Retreg2
Latency to leave start box in cocaine runway, F	3596.44	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	582.2	3	1	20	0	1.00e+00	Ndufb9 Retreg2 Serping1
Co content in liver	1133.25	1	1	20	0	1.00e+00	Retreg2
Cu content in liver	28.08	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Fe content in liver	1344.53	1	1	20	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	20	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	20	0	1.00e+00	Retreg2
Mn content in liver	537.3	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Na content in liver	2013.84	2	1	20	0	1.00e+00	Ndufb9 Retreg2
Rb content in liver	71.08	2	2	40	0	1.00e+00	Ndufb9 Retreg2
Se content in liver	8.63	1	0	0	0	1.00e+00	Ndufb9
Zn content in liver	1887.46	2	2	40	0	1.00e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.16
Adipose	alternative TSS	0	0	1.12
Adipose	gene expression	0	0	1.15
Adipose	isoform ratio	0	0	1.15
Adipose	intron excision ratio	0	0	1.17
Adipose	mRNA stability	2	0	1.17
BLA	alternative polyA	0	0	1.16
BLA	alternative TSS	0	0	1.24
BLA	gene expression	1	0	1.16
BLA	isoform ratio	0	0	1.15
BLA	intron excision ratio	0	0	1.1
BLA	mRNA stability	0	0	1.12
Brain	alternative polyA	0	0	1.19
Brain	alternative TSS	0	0	1.22
Brain	gene expression	1	0	1.15
Brain	isoform ratio	0	0	1.21
Brain	intron excision ratio	0	0	1.12
Brain	mRNA stability	0	0	1.17
Eye	alternative polyA	0	0	1.25
Eye	alternative TSS	0	0	1.13
Eye	gene expression	0	0	1.09
Eye	isoform ratio	0	0	1.11
Eye	intron excision ratio	0	0	1
Eye	mRNA stability	0	0	1.08
IC	alternative polyA	0	0	1.22
IC	alternative TSS	0	0	1.17
IC	gene expression	0	0	1.15
IC	isoform ratio	0	0	1.17
IC	intron excision ratio	0	0	1.1
IC	mRNA stability	0	0	1.13
IL	alternative polyA	0	0	1.17
IL	alternative TSS	0	0	1.15
IL	gene expression	0	0	1.15
IL	isoform ratio	0	0	1.21
IL	intron excision ratio	0	0	1.01
IL	mRNA stability	0	0	1.17
LHb	alternative polyA	0	0	1.16
LHb	alternative TSS	0	0	1.22
LHb	gene expression	0	0	1.16
LHb	isoform ratio	0	0	1.18
LHb	intron excision ratio	0	0	1.02
LHb	mRNA stability	0	0	1.19
Liver	alternative polyA	0	0	1.16
Liver	alternative TSS	0	0	1.14
Liver	gene expression	0	0	1.13
Liver	isoform ratio	0	0	1.09
Liver	intron excision ratio	0	0	1.07
Liver	mRNA stability	0	0	1.07
NAcc	alternative polyA	2	0.1	59.63
NAcc	alternative TSS	0	0	1.24
NAcc	gene expression	0	0	1.14
NAcc	isoform ratio	0	0	1.23
NAcc	intron excision ratio	0	0	1.14
NAcc	mRNA stability	0	0	1.18
OFC	alternative polyA	0	0	1.16
OFC	alternative TSS	0	0	1.2
OFC	gene expression	0	0	1.13
OFC	isoform ratio	0	0	1.26
OFC	intron excision ratio	0	0	1.08
OFC	mRNA stability	0	0	1.16
PL	alternative polyA	0	0	1.18
PL	alternative TSS	0	0	1.19
PL	gene expression	0	0	1.16
PL	isoform ratio	0	0	1.17
PL	intron excision ratio	0	0	1.13
PL	mRNA stability	0	0	1.16
pVTA	alternative polyA	0	0	1.26
pVTA	alternative TSS	0	0	1.25
pVTA	gene expression	0	0	1.14
pVTA	isoform ratio	0	0	1.2
pVTA	intron excision ratio	0	0	1.14
pVTA	mRNA stability	0	0	1.17
RMTg	alternative polyA	0	0	1.03
RMTg	alternative TSS	0	0	1.29
RMTg	gene expression	0	0	1.09
RMTg	isoform ratio	0	0	1.16
RMTg	intron excision ratio	0	0	1.14
RMTg	mRNA stability	0	0	1.17