Tsg101

tumor susceptibility 101

chr1:106549035–106578859 (-)

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_008759341.4	0.04	0.03	7.3e-04	0.03	0.03	0.03	0.03	1.1e-03	1.2e-03	4.2e-04	1.5e-03
2	Brain	isoform ratio	XM_039105117.2	0.13	0.1	6.5e-03	0	0.01	0	-0	1.2e-01	5.7e-02	1.9e-01	4.0e-01
3	Brain	intron excision ratio	chr1_106551503_106565507	0.04	0.03	1.2e-04	0.02	0.04	0.03	0.01	3.4e-03	1.5e-04	8.8e-04	2.6e-02
4	Liver	gene expression	Tsg101	0.06	0.06	1.3e-04	0.03	0.02	0.02	0.03	4.6e-04	1.6e-03	1.8e-03	6.2e-04
5	LHb	intron excision ratio	chr1_106551503_106565507	0.14	0.11	4.1e-03	0.05	0.03	0.07	0.06	2.3e-02	6.2e-02	9.4e-03	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.7	1.1	3.4	1.9	-1.3	0.5	-0.0	0.4
Area under the delay curve	0.9	1.0	3.9	-2.0	0.9	-0.3	0.0	-0.5
BMI with tail	0.5	1.6	2.8	1.2	-1.7	1.2	-1.0	1.0
BMI without tail	1.1	3.5	10.1	3.2	-2.3	1.0	-0.7	0.8
Body weight	0.6	2.7	6.7	2.6	-2.5	0.6	-0.0	0.6
Weight adjusted by age	2.6	4.0	7.3	-0.2	-1.4	2.5	-2.1	2.7
Bone surface	0.9	1.6	4.5	2.1	-1.4	-0.5	1.0	-0.6
Bone volume	0.7	1.3	3.6	1.9	-1.1	-0.5	1.0	-0.6
Breakpoint value in progressive ratio session	1.1	1.3	4.9	2.2	-1.1	0.0	0.4	0.4
Number of licking bursts	0.1	0.1	0.2	0.3	0.0	-0.4	0.4	-0.4
Context. condit. distance diff. score	0.4	0.5	1.9	0.8	-1.4	0.3	0.2	0.2
Locomotion velocity, session 1	0.4	0.4	1.4	0.7	-1.2	0.4	-0.1	0.2
Locomotion distance, session 1	1.4	1.8	2.9	0.1	-1.3	1.7	-1.6	1.3
Locomotion velocity, session 2	0.2	0.2	0.7	-0.8	-0.2	-0.2	0.3	-0.4
Locomotion distance, session 2	0.1	0.1	0.5	0.3	-0.7	0.2	-0.0	-0.1
Locomotion velocity, session 3	0.2	0.3	0.4	-0.4	0.1	-0.6	0.6	-0.6
Locomotion distance, session 3	0.5	0.6	1.2	-0.0	0.3	-1.0	1.1	-0.8
Stereotopy head waving bouts, day 3	0.5	0.5	1.0	-0.3	1.0	0.5	-1.0	0.7
Stereotopy head waving duration, day 3	0.8	0.9	1.5	-0.8	1.2	0.7	-1.2	0.8
Locomotion velocity, session 7	1.5	1.7	3.4	0.6	-0.8	-1.3	1.9	-1.5
Locomotion distance, session 7	1.1	1.4	3.1	0.3	-0.7	-1.2	1.8	-1.4
Stereotopy head waving bouts, day 7	1.0	1.1	3.5	-1.2	1.9	-0.6	0.1	-0.2
Stereotopy head waving duration, day 7	1.1	1.4	4.2	-1.5	2.0	-0.1	-0.5	0.2
Locomotion velocity, session 8	1.9	2.2	3.9	1.0	-2.0	1.6	-1.3	1.4
Locomotion distance, session 8	2.2	3.2	6.2	1.6	-2.5	1.8	-1.3	1.6
Degree of sensitization distance	0.6	0.6	1.6	0.8	-1.3	0.7	-0.4	0.5
Degree of sensitization stereotypy	1.0	1.1	3.5	-1.1	1.9	-0.7	0.2	-0.3
Conditioned locomotion	0.6	0.7	1.3	0.5	-1.1	-0.6	1.1	-0.6
Cocaine response after cond. corrected	0.3	0.3	0.6	-0.3	-0.0	0.7	-0.7	0.7
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.5	0.2	0.6	-0.7	0.5
Cocaine response before conditioning	0.0	0.0	0.1	-0.1	0.0	-0.1	0.1	-0.2
Saline control response	2.4	3.2	7.6	-1.0	2.8	-1.9	1.2	-1.6
Bone: connectivity density	1.2	1.9	4.0	2.0	-1.8	1.0	-0.6	1.0
Bone: cortical apparent density	0.9	1.2	1.7	-0.5	1.2	-1.3	1.1	-1.2
Bone: cortical area	2.3	3.5	7.0	-2.1	2.7	-1.7	1.2	-1.3
Bone: cortical porosity	0.0	0.0	0.1	-0.2	-0.2	0.0	0.1	0.2
Bone: cortical porosity	0.0	0.1	0.1	-0.3	-0.3	0.1	-0.1	0.3
Bone: cortical thickness	2.7	4.5	14.6	-2.7	3.8	-0.6	-0.3	0.1
Bone: cortical thickness	1.4	1.7	5.4	-0.9	2.3	0.3	-1.1	0.9
Bone: cortical tissue density	0.8	1.0	1.6	-0.3	0.9	-1.2	1.1	-1.2
Condit. Reinf. active minus inactive responses	0.6	0.7	2.7	0.6	-1.6	0.4	0.1	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.4	-0.1	0.6	-0.6	0.7
Condit. Reinf. active responses	1.3	1.6	5.3	1.4	-2.3	0.5	0.2	0.5
Condit. Reinf. inactive responses	1.3	1.5	3.4	1.8	-1.9	-0.2	0.9	-0.2
Incentive salience index mean	1.2	1.5	4.8	1.2	-2.2	0.9	-0.2	0.7
Condit. Reinf. lever presses	0.9	1.2	3.0	1.7	-1.7	0.5	-0.1	0.5
Condit. Reinf. active minus inactive responses	2.7	3.5	4.4	-2.1	2.1	-1.9	1.5	-1.7
Condit. Reinf. active-inactive response ratio	0.8	1.0	1.4	-0.7	1.2	-1.2	1.0	-0.8
Condit. Reinf. active responses	3.1	4.4	5.1	-1.9	2.1	-2.3	2.0	-2.2
Condit. Reinf. inactive responses	0.9	1.2	2.2	-0.9	0.7	-1.1	1.0	-1.5
Condit. Reinf. lever presses	2.0	2.7	3.1	-1.7	1.6	-1.7	1.5	-1.8
Condit. Reinf. lever reinforcers received	3.4	4.7	5.6	-2.1	1.9	-2.3	2.1	-2.4
Conditioned reinforcement - actives	2.3	3.9	10.0	3.2	-2.5	1.2	-0.6	1.3
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.2	-0.6	-0.2	0.5	-0.4
Conditioned locomotion	0.2	0.3	0.7	0.1	-0.1	0.7	-0.7	0.8
Patch foraging indifference point 0 sec	2.0	3.6	5.5	0.1	2.0	-2.3	1.9	-2.2
Patch foraging indifference point AUC	0.8	1.2	2.5	0.4	-1.6	-0.7	1.4	-0.9
Delay disc. indifference point, 0s delay	0.5	0.5	0.8	-0.8	0.5	-0.8	0.6	-0.9
Delay disc. indifference point, 16s delay	0.3	0.4	0.7	-0.2	-0.8	0.8	-0.7	0.3
Delay disc. indifference point, 2s delay	1.2	1.4	5.4	-2.3	1.2	-0.3	-0.1	-0.3
Delay disc. indifference point, 24s delay	2.3	2.5	10.0	-3.2	1.6	-0.2	-0.3	-0.2
Delay disc. indifference point, 4s delay	0.5	0.5	0.9	-0.2	0.2	-0.9	0.8	-0.9
Delay disc. indifference point, 8s delay	1.1	1.3	5.1	-2.3	1.1	-0.3	-0.0	-0.4
Indifference point function ln k	1.2	2.2	6.5	-2.0	2.6	-0.5	-0.4	-0.3
Indifference point function log k	1.2	2.2	6.5	-2.0	2.6	-0.5	-0.4	-0.3
Patch foraging total patch changes 0 sec	2.2	4.1	5.9	-0.6	2.3	-2.4	1.9	-2.3
Patch foraging total patch changes 12 sec	0.9	1.2	2.2	0.0	0.0	-1.3	1.4	-1.5
Patch foraging total patch changes 18 sec	2.0	3.0	4.4	1.9	-1.6	-1.4	2.1	-1.5
Patch foraging total patch changes 24 sec	1.0	1.6	3.4	1.8	-1.4	-0.7	1.3	-0.9
Patch foraging total patch changes 6 sec	0.6	1.0	1.7	-0.0	0.5	-1.3	1.2	-1.3
Patch foraging time to switch 0 sec	1.1	2.3	3.0	1.7	-1.7	1.5	-1.3	1.2
Patch foraging water rate 0 sec	1.1	2.3	4.0	-1.8	2.0	-1.4	1.2	-0.8
Patch foraging water rate 12 sec	0.6	1.2	2.8	-1.6	1.7	-0.6	0.1	-0.4
Patch foraging water rate 18 sec	0.8	1.3	5.0	-2.2	1.2	-0.0	-0.3	-0.1
Patch foraging water rate 24 sec	0.7	1.0	3.3	-1.8	1.2	0.2	-0.4	0.4
Patch foraging water rate 6 sec	4.2	6.1	13.9	-3.7	3.1	-1.7	1.3	-1.6
Seeking ratio, delayed vs. immediate footshock	5.5	6.7	25.7	-5.1	2.6	-0.7	0.1	-0.8
Distance traveled before self-admin	0.3	0.4	0.8	0.5	-0.9	-0.3	0.5	-0.8
Distance traveled after self-admin	1.6	1.9	4.2	2.0	-1.3	1.3	-1.0	1.0
Extensor digitorum longus weight	0.8	3.1	4.7	1.8	-1.0	1.8	-1.7	2.2
Bone: elastic displacement	0.4	0.5	0.7	-0.0	-0.8	0.8	-0.6	0.8
Bone: elastic work	0.6	0.7	1.3	-0.0	-1.1	1.0	-0.6	1.0
Bone: endosteal estimation	1.5	3.2	5.4	1.4	-2.3	-1.1	2.1	-1.8
Bone: endosteal perimeter	1.4	2.9	4.6	1.2	-1.8	-1.3	2.1	-1.9
Epididymis fat weight	0.8	2.6	5.1	2.3	-1.2	1.5	-1.4	1.6
Delta time in closed arm before/after self-admin	2.1	2.0	6.2	2.5	-1.3	-0.6	1.1	-0.6
Delta time in open arm before/after self-admin	4.9	4.9	17.4	-4.2	2.2	-0.9	0.2	-1.0
Diff in mean of infusions in LGA sessions	0.4	0.5	1.3	-1.0	1.1	-0.0	-0.4	0.2
Delay discount exponential model param	0.9	1.0	3.9	2.0	-0.9	0.3	-0.0	0.5
Extinction: sum of active levers before priming	0.6	0.6	1.5	-1.2	1.2	-0.1	-0.4	0.0
Active lever presses in extinction session 6	2.3	2.3	7.7	1.5	-2.8	1.2	-0.3	0.5
Bone: final force	0.1	0.2	0.8	-0.9	0.3	0.2	-0.2	0.2
Bone: final moment	0.1	0.1	0.5	-0.7	0.0	0.0	0.1	0.0
Food consumed during 24 hour testing period	0.5	0.7	1.4	0.0	-0.7	-0.7	1.1	-1.2
Glucose	2.3	3.6	10.9	-2.3	3.3	-1.1	0.3	-0.5
Heart weight	0.1	0.1	0.3	0.2	-0.5	0.2	-0.0	0.5
Delay discount hyperbolic model param	1.0	1.1	4.2	2.1	-1.1	0.3	0.1	0.4
Intermittent access intake day 1-15 change	1.3	2.6	9.7	3.1	-1.7	-0.2	0.8	0.1
Intermittent access intake escalation	1.2	2.5	9.2	3.0	-1.6	-0.3	0.9	0.1
Intermittent access intake escalation 2	1.5	1.7	8.1	2.9	-0.1	-0.0	0.0	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.2	-0.1	-0.3	-0.5	0.5	-1.1
Intermitt. access day 15 inactive lever presses	1.6	3.3	5.7	1.3	-0.0	-2.1	2.4	-2.2
Intermitt. access escalation Index	2.8	3.9	11.4	3.4	-1.9	1.2	-0.6	1.7
Intermittent access day 1 total infusions	1.0	1.6	4.8	2.2	-1.2	-0.6	1.0	-0.4
Intermittent access day 15 total infusions	1.8	2.7	8.9	3.0	-1.5	-0.8	1.3	-0.4
Intermittent access terminal intake (last 3 days)	1.5	2.0	7.1	2.7	-0.1	-1.1	1.1	-0.6
Intermittent access total infusions	1.2	1.4	3.3	1.8	-0.3	-1.1	1.2	-0.8
Intermittent access day 1 locomotion	0.8	1.0	1.6	0.5	-1.2	-0.8	1.3	-1.0
Intermittent access day 15 total locomotion	0.3	0.6	1.3	-0.3	0.3	0.7	-1.1	1.0
Intermittent access total locomotion	0.0	0.1	0.1	0.1	0.1	0.1	-0.3	0.4
Intermittent access standard deviation	0.8	1.6	7.2	2.7	-0.7	-0.4	0.4	-0.3
Left kidney weight	0.3	1.5	2.9	1.7	-1.5	-0.6	1.3	-0.4
Right kidney weight	0.2	0.7	1.7	0.3	-0.8	-0.9	1.3	-0.7
Cocaine induced anxiety	0.5	0.7	1.3	-0.9	0.1	-0.7	0.9	-1.2
Post-drug Anxiety	0.1	0.2	0.5	0.7	-0.3	0.0	0.1	-0.3
Baseline Anxiety	1.9	2.2	3.8	1.1	-0.1	1.7	-1.9	1.8
Tail length	0.4	1.7	2.5	1.6	-1.0	-1.2	1.5	-1.2
Length with tail	0.3	1.2	3.2	1.8	-1.5	-0.2	0.8	-0.2
Length without tail	0.1	0.3	0.6	0.4	-0.8	0.5	-0.3	0.7
LgA early post infusion interval	1.8	2.4	8.5	-2.9	1.7	0.1	-0.6	0.2
LgA late post infusion interval	1.1	1.3	6.3	2.5	-0.2	0.1	-0.3	0.1
LgA early loading	1.9	3.5	8.2	2.9	-2.0	-1.1	1.9	-0.9
LgA late loading	0.2	0.5	1.0	-1.0	0.2	0.6	-0.8	0.8
LgA early average infusions	2.1	2.7	8.3	2.9	-1.8	-0.6	1.1	-0.2
LgA late average infusions	0.2	0.3	0.6	-0.8	0.7	-0.6	0.2	-0.3
LgA early timeout	2.3	2.5	5.2	2.3	-1.5	-1.1	1.7	-1.0
LgA late timeout	0.3	0.4	1.4	1.2	0.5	-0.2	-0.2	-0.1
LgA early titration	2.2	3.1	8.8	3.0	-1.8	-0.9	1.5	-0.7
LgA late titration	3.8	5.7	10.4	-3.2	1.9	-2.2	1.9	-2.5
LgA total infusion	0.8	1.2	4.4	2.1	-1.0	-0.3	0.6	0.1
Times rat made contact with spout	0.3	0.3	1.0	0.6	-1.0	0.5	-0.2	0.3
Lifetime Intake	1.6	1.9	5.3	2.3	-1.0	-1.0	1.4	-0.7
Liver weight, left	0.4	0.6	2.9	-1.7	0.3	-0.0	0.1	0.1
Liver weight, right	0.2	0.3	0.5	-0.4	0.4	-0.6	0.6	-0.7
Locomotor activity	0.4	0.6	2.6	1.6	-0.3	0.1	-0.2	0.4
Locomotor testing distance	0.5	0.9	3.8	1.9	-1.0	0.1	-0.1	0.1
Locomotor testing rearing	0.4	0.9	1.2	0.9	-0.5	-1.0	1.1	-1.0
Locomotion in novel chamber	0.6	0.8	1.9	1.4	-1.0	0.5	-0.6	0.6
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	0.4	0.1	-0.2	0.3	-0.3
Fecal boli incidents, locomotor time 1	2.6	3.8	5.8	0.1	2.4	-2.4	2.0	-1.9
Change in fecal boli incidents, locomotor task	2.0	2.0	9.3	-3.1	0.7	-0.2	-0.5	-0.1
Time >=10cm from walls, locomotor time 1	1.3	1.4	2.3	-1.5	1.0	-1.2	1.3	-0.8
Bouts of movement, locomotor time 1	1.3	1.4	6.3	0.1	2.5	-0.9	0.0	-0.4
Total resting periods, locomotor time 1	1.5	1.6	7.2	0.4	2.7	-0.8	-0.2	-0.2
Rest time, locomotor task time 1	1.5	1.9	6.8	-1.0	2.6	-1.1	0.0	-0.8
Distance moved, locomotor task time 1	2.0	3.1	5.1	0.1	-2.1	2.2	-1.7	1.7
Vertical activity count, locomotor time 1	0.5	1.3	5.7	0.3	-2.4	0.7	0.2	0.1
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.7	-0.8	-0.6	-0.2	0.6	-0.3
Bouts of movement, locomotor time 2	0.3	0.4	1.7	-0.4	1.3	-0.5	0.2	0.1
Total resting periods, locomotor time 2	0.4	0.8	2.5	-1.0	1.6	-0.5	0.3	-0.1
Rest time, locomotor task time 2	2.0	2.5	11.1	-3.3	1.0	-0.0	-0.5	-0.1
Distance moved, locomotor task time 2	6.3	7.5	20.8	4.6	-3.6	1.6	-0.5	0.9
Vertical activity count, locomotor time 2	3.2	4.4	11.0	3.3	-3.1	0.1	0.9	-0.6
Light reinforcement 1	0.0	0.1	0.2	0.5	0.3	-0.2	0.2	0.2
Light reinforcement 2	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.2	-0.4
Bone: marrow area	1.4	3.1	5.9	1.5	-2.4	-1.0	2.0	-1.7
Bone: maximum diameter	1.3	2.4	3.0	-1.3	1.5	-1.7	1.5	-1.6
Bone: maximum force	0.2	0.3	0.9	-1.0	0.6	-0.1	0.0	0.0
Bone: maximum moment	0.1	0.2	0.5	-0.7	0.2	-0.2	0.4	-0.2
Mean time between licks in bursts	0.2	0.5	1.0	0.1	0.5	0.8	-1.0	0.8
Mean num. licks in bursts	0.2	0.3	0.6	0.4	-0.8	0.7	-0.5	0.5
Cd content in liver	0.8	0.9	1.8	0.0	0.2	-1.2	1.4	-1.1
Co content in liver	0.3	0.3	0.7	0.1	-0.3	-0.6	0.7	-0.8
Cu content in liver	0.0	0.0	0.1	-0.2	0.3	0.0	-0.2	-0.1
Fe content in liver	0.2	0.2	0.3	0.5	-0.1	0.5	-0.5	0.4
K content in liver	0.1	0.1	0.5	0.3	-0.7	-0.0	0.2	-0.2
Mg content in liver	0.1	0.1	0.4	0.4	-0.6	0.1	0.1	-0.2
Mn content in liver	0.6	0.7	2.2	-1.5	0.9	-0.4	0.2	-0.5
Na content in liver	0.1	0.1	0.6	-0.8	-0.0	-0.0	-0.0	-0.2
Rb content in liver	0.4	0.4	1.6	1.3	-0.8	0.2	-0.1	0.0
Se content in liver	0.1	0.1	0.2	-0.2	-0.2	0.4	-0.4	0.2
Sr content in liver	0.1	0.0	0.1	0.2	0.1	-0.2	0.3	-0.2
Zn content in liver	0.4	0.5	1.0	0.7	-1.0	0.6	-0.5	0.5
Bone: minimum diameter	0.6	1.0	1.8	-0.5	0.5	-1.2	1.3	-1.2
Time in familiar zone, hab. session 1	1.1	1.1	2.0	1.4	-0.2	-1.0	1.2	-0.9
Time in novel zone, hab. session 1	0.6	0.6	1.0	-0.3	-0.4	1.0	-0.9	0.9
Total zone transitions, hab. session 1	0.3	0.4	0.7	-0.4	-0.3	0.8	-0.8	0.6
Total locomotion distance, hab. session 1	0.2	0.2	0.9	-0.2	-0.9	0.4	-0.2	0.2
Locomotion velocity, hab. session 1	0.4	0.6	0.8	-0.6	-0.8	0.9	-0.8	0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.5	-0.0	0.0	-0.1	-0.2
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.7	0.3	0.3	-0.3	0.6
Total zone transitions, hab. session 2	0.2	0.3	0.6	0.7	-0.8	0.5	-0.2	0.3
Total locomotion distance, hab. session 2	0.5	0.6	0.8	0.5	-0.8	0.9	-0.8	0.9
Locomotion velocity, hab. session 2	0.3	0.5	0.7	0.6	-0.8	0.7	-0.6	0.7
Novel to familiar place preference ratio	0.3	0.3	0.5	-0.2	0.2	-0.6	0.6	-0.7
Novelty place preference	0.2	0.3	0.5	-0.1	0.1	-0.6	0.6	-0.7
Time in novel zone, NPP test	0.3	0.3	0.6	0.1	-0.2	-0.6	0.8	-0.7
Total zone transitions, NPP test	0.5	0.7	1.4	-0.2	0.1	1.1	-1.2	1.1
Total locomotion distance, NPP test	1.4	1.8	3.5	-0.6	0.2	1.6	-1.9	1.6
Locomotion velocity, NPP test	1.7	2.4	4.6	-0.8	0.4	1.8	-2.1	1.8
Intraocular pressure	2.0	2.9	4.7	0.3	0.9	-2.2	2.1	-2.0
Delta distance traveled before/after self-admin	2.4	2.5	6.4	2.5	-1.0	1.3	-1.1	1.5
Delta ambulatory time before/after self-admin	1.6	2.0	3.3	1.8	-1.0	1.4	-1.2	1.5
Parametrial fat weight	1.0	2.4	4.5	0.1	0.6	1.6	-2.1	2.1
Pavlov. Cond. lever latency	0.2	0.3	0.9	-1.0	0.3	-0.1	-0.1	-0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.1	0.5	-0.3	0.2	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.2	0.5	-0.3	0.2	-0.0
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	0.4	-0.4	0.4	-0.2
Pavlov. Cond. latency score	0.2	0.2	0.4	0.6	0.3	-0.5	0.5	-0.2
Pavlov. Cond. lever contacts	0.2	0.3	1.1	1.1	-0.2	0.1	-0.1	0.5
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.4	-0.3	-0.0	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.3	0.2	-1.1	0.0	0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	0.4	-0.3	0.2	-0.0
Pavlov. Cond. response bias	0.2	0.2	0.4	0.6	-0.0	0.5	-0.5	0.6
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	-0.8	0.4	-0.3	0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.5	0.1	0.7	-0.9	0.6
Pavlov. Cond. change in total contacts	0.3	0.5	0.9	-0.5	-0.1	-0.7	0.9	-0.9
Pavlov. Cond. index score	0.1	0.1	0.3	-0.5	0.3	-0.0	-0.0	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.3	0.2	-0.2	0.1
Pavlov. Cond. lever contacts	0.4	0.6	1.3	-0.9	1.2	-0.5	0.4	-0.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.0	0.6	-0.5	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	0.5	0.5	-0.5	0.5	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.5	0.3	-0.0	-0.0	-0.1
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.9	0.7	-0.5	0.4	-0.7
LgA PC1 addiction-like behavior	0.7	1.4	4.7	2.2	-1.3	-0.2	0.6	-0.2
Time in closed arm before self-admin	0.8	1.1	3.3	1.8	-0.5	0.7	-0.6	0.9
Time in closed arm after self-admin	3.3	3.6	16.0	4.0	-1.0	-0.4	0.9	0.1
Time in open arm before self-admin	1.2	1.3	3.0	1.2	-1.7	1.1	-0.7	0.8
Time in open arm after self-admin	5.3	5.9	26.2	-5.1	0.9	0.7	-1.4	-0.0
Bone: periosteal estimation	0.9	1.9	3.6	-0.4	0.1	-1.6	1.9	-1.8
Bone: periosteal perimeter	1.0	1.8	2.7	-0.5	0.9	-1.6	1.6	-1.6
Bone: post-yield work	0.4	0.5	0.8	0.1	0.7	-0.9	0.7	-0.9
Progressive ratio test 1 active lever presses	0.7	0.9	1.6	0.5	-1.0	-0.8	1.3	-0.9
Progressive ratio test 1 breakpoint	0.6	0.7	1.4	0.1	-0.7	-0.8	1.2	-0.9
Progressive ratio test 1 inactive lever presses	1.4	2.0	3.4	0.7	-1.7	-1.1	1.9	-1.3
Progressive ratio test 2 active lever presses	1.1	1.3	2.9	1.7	-0.7	-1.0	1.3	-0.9
Progressive ratio test 2 breakpoint	1.2	1.4	2.7	1.6	-0.7	-1.0	1.4	-0.9
Progressive ratio test 2 inactive lever presses	2.2	3.5	11.1	3.3	-2.2	-0.5	1.1	-0.3
ShA PR total presses	0.5	0.6	1.4	1.2	-1.1	0.3	-0.1	0.5
Incentive Sensitization - Responses	0.8	1.2	2.0	1.4	0.1	-1.2	1.4	-0.8
Incentive Sensitization - Breakpoint	0.9	1.2	2.1	1.3	0.1	-1.2	1.4	-0.9
LgA PR total presses	1.6	1.7	2.7	-0.1	-1.1	1.5	-1.6	1.5
Sum of active levers in priming session hrs 5-6	1.0	1.0	4.0	2.0	-0.8	0.2	0.1	0.4
Progressive ratio	1.5	2.3	6.5	2.6	-2.2	0.4	0.3	0.3
Food seeking constrained by brief footshock	2.2	2.6	10.6	3.3	-1.1	0.5	-0.7	0.8
Seeking ratio, punishment vs. effort	0.3	0.5	1.8	-0.0	1.3	-0.6	0.1	-0.3
Retroperitoneal fat weight	0.4	1.7	3.3	0.5	-0.1	1.5	-1.6	1.8
Reaction time number correct	3.8	7.3	12.8	-0.2	-2.4	3.6	-3.0	3.0
Reaction time mean minus median	0.2	0.4	0.7	0.1	0.6	-0.8	0.8	-0.6
Reaction time mean minus median AUC	0.2	0.5	0.8	-0.2	0.6	-0.9	0.9	-0.6
Reaction time num false alarms	0.8	1.1	2.1	1.5	-0.9	-0.7	1.1	-0.9
Reaction time num false alarms AUC	0.7	1.0	1.6	1.3	-1.0	-0.7	1.1	-0.8
Reaction time trials correct on left	3.8	7.3	12.8	-0.2	-2.4	3.6	-3.0	3.0
Reaction time trials on left	3.9	7.3	12.6	-0.0	-2.5	3.6	-2.9	3.0
Reaction time mean	2.3	3.6	4.9	-1.4	1.3	-2.2	2.2	-2.1
Reaction time mean AUC	2.0	3.2	4.4	-1.3	1.2	-2.1	2.0	-2.0
Median of all reaction times	3.1	4.4	6.1	-1.6	1.3	-2.5	2.4	-2.4
Reaction time omissions	0.6	0.8	3.0	1.7	-0.1	-0.7	0.6	-0.5
Reaction time false alarm rate	2.4	3.3	5.5	1.1	0.4	-2.3	2.4	-2.1
Reaction time premature initiation rate	0.3	0.4	0.7	0.7	-0.2	-0.7	0.7	-0.8
Reaction time premature initiations	0.6	1.0	2.7	0.7	-1.6	1.1	-0.7	0.7
Std. dev. reaction times	1.5	2.7	4.2	-0.4	1.3	-2.1	2.0	-1.8
Reaction time trials completed	3.9	7.3	12.6	-0.0	-2.5	3.6	-2.9	3.0
Reaction time trials AUC	3.8	7.3	12.6	-0.1	-2.5	3.6	-2.9	3.0
Run reversals in cocaine runway, females	1.0	1.0	3.8	-1.9	0.0	-0.5	0.9	-0.7
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.3	-0.4	0.6	-0.6	0.4
Latency to leave start box in cocaine runway	0.4	0.4	1.8	-1.3	-0.4	-0.0	0.2	0.0
Latency to leave start box in cocaine runway, F	0.5	0.6	1.2	-1.1	-0.8	-0.3	0.8	-0.4
Latency to leave start box in cocaine runway, M	0.2	0.1	0.3	-0.4	0.2	0.3	-0.5	0.4
Std. dev. time between licks in bursts	2.5	3.4	7.5	-2.1	2.7	-1.6	1.1	-1.3
Total sessions with >9 infusions	1.1	1.4	2.8	1.7	-1.5	-0.4	1.2	-0.5
Short access day 1 total inactive lever presses	1.8	2.4	3.0	-1.7	0.8	-1.7	1.7	-1.5
Short access day 10 total inactive lever presses	1.1	2.7	8.1	-2.8	1.8	-0.9	0.2	-1.1
Short access day 1 total infusions	0.9	1.2	2.8	1.7	-1.1	-0.5	1.2	-0.3
Short access day 10 total infusions	1.2	1.6	3.8	2.0	-0.7	-1.0	1.4	-0.8
Short access total infusions	2.1	2.6	8.4	2.9	-1.7	-0.5	1.3	-0.1
ShA early post infusion interval	12.0	11.3	30.3	-5.5	3.4	-2.5	1.8	-2.1
ShA late post infusion interval	7.7	7.7	27.0	-5.2	3.1	-0.5	-0.5	-1.0
ShA early loading	10.0	10.1	27.4	5.2	-3.2	2.2	-1.6	2.3
ShA late loading	3.5	4.7	14.4	3.8	-2.3	1.0	-0.8	1.5
Short access day 1 locomotion	0.8	1.0	2.7	1.7	-1.3	-0.2	0.7	-0.5
Short access day 10 total locomotion	0.2	0.3	0.6	0.4	-0.8	0.5	-0.5	0.3
Short access total locomotion	0.1	0.1	0.3	0.2	-0.6	-0.0	0.2	-0.2
ShA early average infusions	9.0	10.6	27.5	5.2	-3.4	2.3	-1.8	2.3
ShA late average infusions	3.1	3.2	9.9	3.2	-2.3	0.4	0.1	0.7
ShA early timeout	10.9	11.1	38.3	6.2	-3.5	1.5	-0.9	1.5
ShA late timeout	4.3	4.6	13.6	3.7	-2.7	-0.5	1.4	-0.4
ShA early titration	6.2	6.8	19.0	4.4	-3.2	1.5	-0.8	1.4
ShA late titration	0.8	0.9	2.9	1.7	-1.1	-0.0	0.1	0.3
ShA total infusions	5.2	6.4	21.0	4.6	-2.9	0.9	-0.5	1.3
One hour access (0.3 mA shock)	1.7	1.9	5.5	2.3	-2.0	0.2	0.3	0.2
Shock compulsivity	0.1	0.2	1.0	1.0	-0.1	0.0	-0.2	0.5
Compulsive drug intake	1.4	1.7	5.4	1.5	-2.3	0.5	0.4	0.6
One hour access (shock baseline)	0.4	0.6	2.6	1.6	-0.7	-0.1	0.2	-0.2
Social response proportion	0.8	0.9	1.4	0.9	0.6	-1.2	1.1	-0.7
Social responses	0.9	1.2	4.8	2.2	-0.7	-0.2	0.6	0.1
Social time	0.2	0.3	0.7	0.3	0.4	-0.8	0.6	-0.6
Soleus weight	0.8	2.4	3.4	1.3	-0.6	1.8	-1.9	1.8
Bone: stiffness	0.6	1.0	2.5	-1.4	1.6	0.3	-0.7	0.5
Tibialis anterior weight	0.4	1.2	2.3	1.1	-0.3	1.1	-1.2	1.5
Time to tail flick, vehicle, before self-admin	1.1	1.2	2.6	-0.7	0.8	1.0	-1.6	1.0
Time to tail flick, vehicle, after self-admin	0.5	0.6	2.9	1.7	-0.1	-0.3	0.2	0.0
Time to tail flick, test, before self-admin	4.1	4.2	9.5	-3.0	3.1	-1.2	0.4	-0.8
Time to tail flick, test, after self-admin	1.9	2.0	2.9	-1.3	1.7	0.9	-1.6	1.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.3	1.2	-0.8	-0.0	0.3	0.2
Delta time to tail flick, test, before/after SA	3.3	3.4	5.2	1.6	-2.3	2.0	-1.5	1.7
Tibia length	0.6	1.6	3.8	1.5	-2.0	-0.4	1.0	-0.7
Ambulatory time before self-admin	0.5	0.8	2.0	-0.3	-0.4	-0.8	1.0	-1.4
Ambulatory time after self-admin	1.2	1.4	3.7	1.7	-1.9	0.7	-0.1	0.3
Bone: tissue strength	0.5	0.5	0.7	-0.4	-0.6	0.8	-0.7	0.8
Total heroin consumption	0.7	0.8	4.0	2.0	-0.3	-0.1	0.2	0.1
Total infusions	1.5	1.9	7.2	2.7	-1.4	0.1	0.2	0.5
Bone: trabecular number	0.7	1.2	4.0	2.0	-1.3	0.3	0.1	0.2
Bone: trabecular spacing	0.1	0.1	0.6	-0.8	0.2	-0.0	0.0	-0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.5	-0.2	-0.1	0.3	0.1
Bone: trabecular tissue density	2.0	3.0	5.2	-0.5	1.0	-2.2	2.3	-1.9
Water consumed over 24 hours	0.2	0.2	0.5	0.5	-0.7	0.5	-0.3	0.3
Number of responses in last shaping day	1.3	1.5	6.2	0.8	-2.5	0.7	0.1	0.1