LgA late titration

The total sum of the number of infusions taken in the last hour of days 11-14 of long access

Tags: Behavior · Cocaine

Project: u01_olivier_george_cocaine

4 loci · 4 genes with independent associations · 4 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr3 89562573 90958818 1 1 6.19e-16 1.31e-01 1.27e-46 Serping1
2 chr7 92127461 93066096 1 1 1.81e-15 1.54e-02 1.00e+00 Ndufb9
3 chr8 117463629 118343328 1 1 1.34e-07 6.49e-01 1.00e+00 Mst1
4 chr9 83390749 84777604 1 1 0.00e+00 4.20e-01 1.00e+00 Retreg2

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 439.52 2 2 50 0 1.00e+00 Ndufb9 Retreg2
BMI without tail 19087.12 3 2 50 0 1.00e+00 Ndufb9 Retreg2 Serping1
Body weight 8.94 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Epididymis fat weight 12102.23 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Glucose 226.07 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Heart weight 1027.64 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Left kidney weight 27527.72 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Right kidney weight 13476.76 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Tail length 7231.22 4 1 25 1 5.99e-04 Mst1 Ndufb9 Retreg2 Serping1
Length with tail 501.6 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Length without tail 15751.67 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Liver weight, left 1172.72 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Liver weight, right 31.51 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Parametrial fat weight 181.56 1 1 25 0 1.00e+00 Retreg2
Retroperitoneal fat weight 1985.63 2 2 50 0 1.00e+00 Mst1 Retreg2
Intraocular pressure 5195.51 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Extensor digitorum longus weight 541.05 2 1 25 0 1.00e+00 Mst1 Retreg2
Soleus weight 9.26 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Tibialis anterior weight 580.28 2 1 25 0 1.00e+00 Mst1 Retreg2
Tibia length 265.42 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Number of licking bursts 33715.83 2 1 25 0 1.00e+00 Retreg2 Serping1
Food consumed during 24 hour testing period 17761.06 2 1 25 0 1.00e+00 Mst1 Retreg2
Times rat made contact with spout 41.61 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Mean time between licks in bursts 55817.09 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Mean num. licks in bursts 28377.98 2 1 25 0 1.00e+00 Retreg2 Serping1
Std. dev. time between licks in bursts 14881.26 2 1 25 0 1.00e+00 Mst1 Retreg2
Water consumed over 24 hours 17087.8 2 1 25 0 1.00e+00 Mst1 Retreg2
Patch foraging indifference point 0 sec 19591.07 2 1 25 0 1.00e+00 Mst1 Retreg2
Patch foraging indifference point AUC 16748.54 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Indifference point function ln k 18623.38 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Indifference point function log k 18623.38 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 0 sec 20977.37 2 1 25 0 1.00e+00 Mst1 Retreg2
Patch foraging total patch changes 12 sec 804.18 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 18 sec 13495.16 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 24 sec 24981.36 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 6 sec 2603.49 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging time to switch 0 sec 22171.85 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging water rate 0 sec 30219.01 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Patch foraging water rate 12 sec 35322.91 2 1 25 0 1.00e+00 Mst1 Retreg2
Patch foraging water rate 18 sec 11246.65 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Patch foraging water rate 24 sec 523.92 2 1 25 0 1.00e+00 Mst1 Retreg2
Patch foraging water rate 6 sec 435.09 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Locomotor activity 15.46 2 1 25 0 1.00e+00 Mst1 Ndufb9
Locomotor testing distance 9234.88 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Locomotor testing rearing 21145.02 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Light reinforcement 1 22106.16 3 1 25 0 1.00e+00 Mst1 Retreg2 Serping1
Light reinforcement 2 12266.98 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Reaction time number correct 31744.5 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Reaction time mean minus median 39986.09 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Reaction time mean minus median AUC 41341.25 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Reaction time num false alarms 7685.9 2 1 25 0 1.00e+00 Mst1 Retreg2
Reaction time num false alarms AUC 17513.8 2 1 25 0 1.00e+00 Mst1 Retreg2
Reaction time trials correct on left 31744.5 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Reaction time trials on left 30449.82 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Reaction time mean 29724.21 1 1 25 0 1.00e+00 Retreg2
Reaction time mean AUC 38768 1 1 25 0 1.00e+00 Retreg2
Median of all reaction times 7893.84 1 1 25 0 1.00e+00 Retreg2
Reaction time omissions 2792.39 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Reaction time false alarm rate 76.38 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Reaction time premature initiation rate 9733.76 1 1 25 0 1.00e+00 Retreg2
Reaction time premature initiations 53743.58 1 1 25 0 1.00e+00 Retreg2
Std. dev. reaction times 20293.6 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Reaction time trials completed 30449.82 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Reaction time trials AUC 31071.82 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Social response proportion 2933.92 3 1 25 0 1.00e+00 Mst1 Retreg2 Serping1
Social responses 324.9 4 1 25 -1 2.45e-03 Mst1 Ndufb9 Retreg2 Serping1
Social time 3887.4 3 1 25 0 1.00e+00 Mst1 Retreg2 Serping1
Conditioned locomotion 1400.08 1 1 25 0 1.00e+00 Retreg2
Cocaine response after cond. corrected 19128.47 1 1 25 0 1.00e+00 Retreg2
Cocaine response after cond. not corrected 18571.31 1 1 25 0 1.00e+00 Retreg2
Cocaine response before conditioning 655.41 1 1 25 0 1.00e+00 Retreg2
Saline control response 1639.18 2 2 50 0 1.00e+00 Mst1 Retreg2
Condit. Reinf. active minus inactive responses 7271.32 2 2 50 0 1.00e+00 Mst1 Retreg2
Condit. Reinf. active-inactive response ratio 14360.59 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Condit. Reinf. active responses 1165.18 2 2 50 0 1.00e+00 Mst1 Retreg2
Condit. Reinf. inactive responses 5466.41 2 2 50 0 1.00e+00 Mst1 Retreg2
Condit. Reinf. lever presses 1311.07 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received 243.91 2 1 25 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. lever latency 1278.33 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. magazine entry latency 6738.25 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. change in total contacts 19909.31 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Pavlov. Cond. index score 6407.33 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. latency score 8109.24 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. lever contacts 2689.72 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. magazine entry number 2097.69 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries 17558.57 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff. 5938.34 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. response bias 641.31 2 2 50 0 1.00e+00 Mst1 Retreg2
Conditioned reinforcement - actives 50420.83 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Conditioned reinforcement - inactives 21684.99 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Conditioned locomotion 3472.27 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Intermittent access intake day 1-15 change 63945.95 2 2 50 0 1.00e+00 Mst1 Retreg2
Intermittent access intake escalation 63041.23 2 2 50 0 1.00e+00 Mst1 Retreg2
Intermittent access intake escalation 2 18091.79 2 1 25 0 1.00e+00 Mst1 Retreg2
Intermitt. access day 1 inactive lever presses 60230.5 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses 61868.22 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Intermitt. access escalation Index 31137.19 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Intermittent access day 1 total infusions 33063.01 2 1 25 0 1.00e+00 Mst1 Retreg2
Intermittent access day 15 total infusions 48731.91 1 1 25 0 1.00e+00 Retreg2
Intermittent access terminal intake (last 3 days) 24800.59 1 1 25 0 1.00e+00 Retreg2
Intermittent access total infusions 181.04 1 1 25 0 1.00e+00 Retreg2
Intermittent access day 1 locomotion 34964.22 1 1 25 0 1.00e+00 Retreg2
Intermittent access day 15 total locomotion 85548.8 1 1 25 0 1.00e+00 Retreg2
Intermittent access total locomotion 45.91 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Intermittent access standard deviation 56995.61 2 2 50 0 1.00e+00 Mst1 Retreg2
Cocaine induced anxiety 34589.88 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Post-drug Anxiety 1595.89 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Baseline Anxiety 16852.64 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Lifetime Intake 1655.49 1 1 25 0 1.00e+00 Retreg2
Incentive Sensitization - Responses 35692.61 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Incentive Sensitization - Breakpoint 27649.77 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Progressive ratio test 1 active lever presses 15996.07 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Progressive ratio test 1 breakpoint 15154.62 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses 20756.82 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Progressive ratio test 2 active lever presses 7635.38 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Progressive ratio test 2 breakpoint 4274.2 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Progressive ratio test 2 inactive lever presses 24171.65 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Total sessions with >9 infusions 1005.82 2 2 50 0 1.00e+00 Mst1 Retreg2
Short access day 1 total inactive lever presses 13176.84 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Short access day 10 total inactive lever presses 69453.48 2 2 50 0 1.00e+00 Mst1 Retreg2
Short access day 1 total infusions 19198 2 1 25 0 1.00e+00 Mst1 Retreg2
Short access day 10 total infusions 7585.44 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Short access total infusions 8778.92 1 1 25 0 1.00e+00 Retreg2
Short access day 1 locomotion 8283.6 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Short access day 10 total locomotion 44094.34 2 1 25 0 1.00e+00 Mst1 Retreg2
Short access total locomotion 6239.96 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Compulsive drug intake 6234.79 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
One hour access (0.3 mA shock) 1167.82 2 1 25 0 1.00e+00 Ndufb9 Retreg2
One hour access (shock baseline) 54988.81 1 1 25 0 1.00e+00 Retreg2
Number of responses in last shaping day 6812.98 2 1 25 0 1.00e+00 Mst1 Retreg2
Context. condit. distance diff. score 212.47 1 1 25 0 1.00e+00 Retreg2
Locomotion velocity, session 1 1769.63 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Locomotion distance, session 1 1024.77 1 1 25 0 1.00e+00 Retreg2
Locomotion velocity, session 2 1110.36 2 2 50 0 1.00e+00 Mst1 Retreg2
Locomotion distance, session 2 258.11 2 1 25 0 1.00e+00 Mst1 Retreg2
Locomotion velocity, session 3 507.49 1 1 25 0 1.00e+00 Retreg2
Locomotion distance, session 3 4009.46 1 1 25 0 1.00e+00 Retreg2
Stereotopy head waving bouts, day 3 691.91 2 1 25 0 1.00e+00 Mst1 Retreg2
Stereotopy head waving duration, day 3 1446.08 2 1 25 0 1.00e+00 Mst1 Retreg2
Locomotion velocity, session 7 210.64 2 2 50 0 1.00e+00 Mst1 Retreg2
Locomotion distance, session 7 258.34 4 2 50 0.95 4.74e-02 Mst1 Ndufb9 Retreg2 Serping1
Stereotopy head waving bouts, day 7 1279.33 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Stereotopy head waving duration, day 7 1081.37 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Locomotion velocity, session 8 409.23 1 1 25 0 1.00e+00 Retreg2
Locomotion distance, session 8 147.88 1 1 25 0 1.00e+00 Retreg2
Degree of sensitization distance 1889.61 2 2 50 0 1.00e+00 Mst1 Retreg2
Degree of sensitization stereotypy 690.43 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses 957.65 1 1 25 0 1.00e+00 Retreg2
Condit. Reinf. active-inactive response ratio 242.03 1 1 25 0 1.00e+00 Retreg2
Condit. Reinf. active responses 2765.7 1 1 25 0 1.00e+00 Retreg2
Condit. Reinf. inactive responses 1569.87 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Incentive salience index mean 1780.77 2 1 25 0 1.00e+00 Mst1 Retreg2
Condit. Reinf. lever presses 2666.81 2 2 50 0 1.00e+00 Mst1 Retreg2
Time in familiar zone, hab. session 1 5593.23 2 1 25 0 1.00e+00 Mst1 Retreg2
Time in novel zone, hab. session 1 4629.95 2 2 50 0 1.00e+00 Mst1 Retreg2
Total zone transitions, hab. session 1 221.7 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Total locomotion distance, hab. session 1 394.1 1 1 25 0 1.00e+00 Retreg2
Locomotion velocity, hab. session 1 266.96 1 1 25 0 1.00e+00 Retreg2
Time in familiar zone, hab. session 2 2966.16 2 2 50 0 1.00e+00 Mst1 Retreg2
Time in novel zone, hab. session 2 3208.33 2 2 50 0 1.00e+00 Mst1 Retreg2
Total zone transitions, hab. session 2 28.15 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Total locomotion distance, hab. session 2 14.23 2 1 25 0 1.00e+00 Mst1 Retreg2
Locomotion velocity, hab. session 2 31.27 1 1 25 0 1.00e+00 Retreg2
Novel to familiar place preference ratio 7678.6 2 1 25 0 1.00e+00 Mst1 Retreg2
Novelty place preference 7474.7 2 1 25 0 1.00e+00 Mst1 Retreg2
Time in novel zone, NPP test 5350.34 2 1 25 0 1.00e+00 Mst1 Retreg2
Total zone transitions, NPP test 980.79 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Total locomotion distance, NPP test 1687.31 1 1 25 0 1.00e+00 Retreg2
Locomotion velocity, NPP test 953.07 1 1 25 0 1.00e+00 Retreg2
Pavlov. Cond. lever latency 186.46 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Pavlov. Cond. change in total contacts 522.83 2 1 25 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. index score 214.07 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. latency score 224.45 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. lever contacts 252.4 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Pavlov. Cond. magazine entry number 250.94 2 1 25 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries 60.1 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff. 223.77 2 2 50 0 1.00e+00 Mst1 Retreg2
Pavlov. Cond. response bias 303.26 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: apparent density 2735.95 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Bone surface 3109.3 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone volume 4317.38 2 1 25 0 1.00e+00 Mst1 Retreg2
Bone: connectivity density 564.06 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: cortical apparent density 6014.36 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Bone: cortical area 1559.21 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: cortical porosity 150.35 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: cortical porosity 560.57 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Bone: cortical thickness 157.6 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: cortical thickness 996.09 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: cortical tissue density 4339.01 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: elastic displacement 7604.03 1 1 25 0 1.00e+00 Retreg2
Bone: elastic work 195.81 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: endosteal estimation 2975.35 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: endosteal perimeter 5936.33 2 1 25 0 1.00e+00 Mst1 Retreg2
Bone: final force 840.18 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: final moment 146.88 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: marrow area 3148.45 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: maximum diameter 2046.98 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: maximum force 4390.32 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: maximum moment 2024.32 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: minimum diameter 2061.38 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: periosteal estimation 4919.52 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: periosteal perimeter 5722.93 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: post-yield work 6843.13 2 1 25 0 1.00e+00 Mst1 Retreg2
Bone: stiffness 4554.23 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: tissue strength 2995.95 1 1 25 0 1.00e+00 Retreg2
Bone: trabecular number 5387.39 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Bone: trabecular spacing 2669.39 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Bone: trabecular thickness 4257.4 2 2 50 0 1.00e+00 Mst1 Retreg2
Bone: trabecular tissue density 4866.8 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
LgA early post infusion interval 26695.82 2 2 50 0 1.00e+00 Ndufb9 Retreg2
LgA late post infusion interval 8742.62 4 2 50 -1 5.44e-05 Mst1 Ndufb9 Retreg2 Serping1
LgA early loading 36383 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
LgA late loading 46429.27 3 2 50 0 1.00e+00 Ndufb9 Retreg2 Serping1
LgA early average infusions 9744.24 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
LgA late average infusions 21040.08 3 3 75 0 1.00e+00 Ndufb9 Retreg2 Serping1
LgA early timeout 6032.01 2 1 25 0 1.00e+00 Retreg2 Serping1
LgA late timeout 19618.34 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
LgA early titration 31242.14 2 2 50 0 1.00e+00 Ndufb9 Retreg2
LgA total infusion 13541.76 3 3 75 0 1.00e+00 Ndufb9 Retreg2 Serping1
LgA PC1 addiction-like behavior 35059.63 3 3 75 0 1.00e+00 Ndufb9 Retreg2 Serping1
ShA PR total presses 11213.89 2 1 25 0 1.00e+00 Ndufb9 Retreg2
LgA PR total presses 3251.76 2 1 25 0 1.00e+00 Retreg2 Serping1
ShA early post infusion interval 4040.41 2 1 25 0 1.00e+00 Retreg2 Serping1
ShA late post infusion interval 112.64 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
ShA early loading 69.67 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
ShA late loading 18923.33 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
ShA early average infusions 4877.65 4 3 75 -1 6.57e-04 Mst1 Ndufb9 Retreg2 Serping1
ShA late average infusions 2964.4 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
ShA early timeout 156.3 4 2 50 -0.99 7.38e-03 Mst1 Ndufb9 Retreg2 Serping1
ShA late timeout 9217.96 2 1 25 0 1.00e+00 Mst1 Retreg2
ShA early titration 378.85 4 3 75 -1 1.03e-03 Mst1 Ndufb9 Retreg2 Serping1
ShA late titration 3825.48 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
ShA total infusions 12428.56 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Shock compulsivity 58893.87 2 2 50 0 1.00e+00 Retreg2 Serping1
Total infusions 9603.49 3 3 75 0 1.00e+00 Ndufb9 Retreg2 Serping1
Breakpoint value in progressive ratio session 18809.48 2 1 25 0 1.00e+00 Mst1 Retreg2
Distance traveled before self-admin 12640.81 4 1 25 1 1.61e-03 Mst1 Ndufb9 Retreg2 Serping1
Distance traveled after self-admin 32464.08 1 1 25 0 1.00e+00 Retreg2
Delta time in closed arm before/after self-admin 87.3 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Delta time in open arm before/after self-admin 7570.03 2 1 25 0 1.00e+00 Mst1 Retreg2
Diff in mean of infusions in LGA sessions 12226.72 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Extinction: sum of active levers before priming 9494.42 3 3 75 0 1.00e+00 Mst1 Ndufb9 Retreg2
Active lever presses in extinction session 6 384.74 2 2 50 0 1.00e+00 Mst1 Retreg2
Delta distance traveled before/after self-admin 995.12 3 2 50 0 1.00e+00 Ndufb9 Retreg2 Serping1
Delta ambulatory time before/after self-admin 10295.46 3 2 50 0 1.00e+00 Ndufb9 Retreg2 Serping1
Time in closed arm before self-admin 8975.53 3 2 50 0 1.00e+00 Mst1 Retreg2 Serping1
Time in closed arm after self-admin 2326.29 2 2 50 0 1.00e+00 Mst1 Retreg2
Time in open arm before self-admin 2211.03 4 2 50 -0.99 9.67e-03 Mst1 Ndufb9 Retreg2 Serping1
Time in open arm after self-admin 151.54 4 3 75 0.88 1.24e-01 Mst1 Ndufb9 Retreg2 Serping1
Sum of active levers in priming session hrs 5-6 333.45 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Time to tail flick, vehicle, before self-admin 4467.99 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin 14086.87 3 2 50 0 1.00e+00 Ndufb9 Retreg2 Serping1
Time to tail flick, test, before self-admin 2731.5 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Time to tail flick, test, after self-admin 495.28 3 2 50 0 1.00e+00 Mst1 Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA 3297.22 3 3 75 0 1.00e+00 Mst1 Retreg2 Serping1
Delta time to tail flick, test, before/after SA 5236.1 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Ambulatory time before self-admin 39450.17 2 2 50 0 1.00e+00 Retreg2 Serping1
Ambulatory time after self-admin 13311.39 2 1 25 0 1.00e+00 Mst1 Retreg2
Total heroin consumption 240.55 1 1 25 0 1.00e+00 Retreg2
Area under the delay curve 24791.27 1 1 25 0 1.00e+00 Retreg2
Delay disc. indifference point, 0s delay 2159.25 1 1 25 0 1.00e+00 Retreg2
Delay disc. indifference point, 16s delay 21959.9 1 1 25 0 1.00e+00 Retreg2
Delay disc. indifference point, 2s delay 155.27 1 1 25 0 1.00e+00 Retreg2
Delay disc. indifference point, 24s delay 32437.06 1 1 25 0 1.00e+00 Retreg2
Delay disc. indifference point, 4s delay 212.93 3 1 25 0 1.00e+00 Mst1 Ndufb9 Retreg2
Delay disc. indifference point, 8s delay 33362.4 1 1 25 0 1.00e+00 Retreg2
Delay discount exponential model param 16922.54 1 1 25 0 1.00e+00 Retreg2
Delay discount hyperbolic model param 12277.65 1 1 25 0 1.00e+00 Retreg2
Fecal boli incidents, locomotor time 1 61202.36 1 1 25 0 1.00e+00 Retreg2
Change in fecal boli incidents, locomotor task 2849.45 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1 4341.13 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Bouts of movement, locomotor time 1 5395.51 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Total resting periods, locomotor time 1 2793.59 1 1 25 0 1.00e+00 Retreg2
Rest time, locomotor task time 1 7459.87 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Distance moved, locomotor task time 1 22969.35 3 3 75 0 1.00e+00 Ndufb9 Retreg2 Serping1
Vertical activity count, locomotor time 1 71183.11 2 2 50 0 1.00e+00 Retreg2 Serping1
Time >=10cm from walls, locomotor time 2 35584.15 2 1 25 0 1.00e+00 Retreg2 Serping1
Bouts of movement, locomotor time 2 41018.4 2 1 25 0 1.00e+00 Retreg2 Serping1
Total resting periods, locomotor time 2 49525.05 2 1 25 0 1.00e+00 Retreg2 Serping1
Rest time, locomotor task time 2 12756.26 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Distance moved, locomotor task time 2 2829.67 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Vertical activity count, locomotor time 2 26782.26 2 1 25 0 1.00e+00 Retreg2 Serping1
Weight adjusted by age 35416.78 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock 13445.31 1 1 25 0 1.00e+00 Retreg2
Locomotion in novel chamber 1993.33 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Locomotion in novel chamber post-restriction 32715.18 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Progressive ratio 22647.13 3 2 50 0 1.00e+00 Ndufb9 Retreg2 Serping1
Food seeking constrained by brief footshock 941.83 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Seeking ratio, punishment vs. effort 20653.58 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Run reversals in cocaine runway, females 4708.93 2 1 25 0 1.00e+00 Retreg2 Serping1
Run reversals in cocaine runway, males 3884.61 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Latency to leave start box in cocaine runway 16290.75 1 1 25 0 1.00e+00 Retreg2
Latency to leave start box in cocaine runway, F 3596.44 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M 582.2 3 1 25 0 1.00e+00 Ndufb9 Retreg2 Serping1
Co content in liver 1133.25 1 1 25 0 1.00e+00 Retreg2
Cu content in liver 28.08 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Fe content in liver 1344.53 1 1 25 0 1.00e+00 Retreg2
K content in liver 1519.62 1 1 25 0 1.00e+00 Retreg2
Mg content in liver 6026.97 1 1 25 0 1.00e+00 Retreg2
Mn content in liver 537.3 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Na content in liver 2013.84 2 1 25 0 1.00e+00 Ndufb9 Retreg2
Rb content in liver 71.08 2 2 50 0 1.00e+00 Ndufb9 Retreg2
Se content in liver 8.63 1 0 0 0 1.00e+00 Ndufb9
Zn content in liver 1887.46 2 2 50 0 1.00e+00 Ndufb9 Retreg2

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.06
Adipose alternative TSS 0 0 1.01
Adipose gene expression 0 0 1.09
Adipose isoform ratio 0 0 1.07
Adipose intron excision ratio 0 0 1.11
Adipose mRNA stability 2 0 1.09
BLA alternative polyA 0 0 1.1
BLA alternative TSS 0 0 1.22
BLA gene expression 0 0 1.12
BLA isoform ratio 0 0 1.12
BLA intron excision ratio 0 0 1.04
BLA mRNA stability 0 0 1.1
Brain alternative polyA 0 0 1.09
Brain alternative TSS 0 0 1.15
Brain gene expression 0 0 1.1
Brain isoform ratio 0 0 1.11
Brain intron excision ratio 0 0 1.08
Brain mRNA stability 0 0 1.15
Eye alternative polyA 0 0 1.06
Eye alternative TSS 0 0 1.11
Eye gene expression 0 0 1.05
Eye isoform ratio 0 0 1.06
Eye intron excision ratio 0 0 1.07
Eye mRNA stability 0 0 1.08
IC alternative polyA 0 0 1.06
IC alternative TSS 0 0 1.1
IC gene expression 0 0 1.15
IC isoform ratio 0 0 1.1
IC intron excision ratio 0 0 1.17
IC mRNA stability 0 0 1.18
IL alternative polyA 0 0 1.11
IL alternative TSS 0 0 1.12
IL gene expression 0 0 1.13
IL isoform ratio 0 0 1.12
IL intron excision ratio 0 0 0.96
IL mRNA stability 0 0 1.13
LHb alternative polyA 0 0 1.11
LHb alternative TSS 0 0 1.22
LHb gene expression 0 0 1.15
LHb isoform ratio 0 0 1.11
LHb intron excision ratio 0 0 1.04
LHb mRNA stability 0 0 1.13
Liver alternative polyA 0 0 1.03
Liver alternative TSS 0 0 1.06
Liver gene expression 0 0 1.07
Liver isoform ratio 1 0 1.05
Liver intron excision ratio 0 0 1.07
Liver mRNA stability 0 0 1.02
NAcc alternative polyA 1 0 30.09
NAcc alternative TSS 0 0 1.19
NAcc gene expression 0 0 1.13
NAcc isoform ratio 0 0 1.13
NAcc intron excision ratio 0 0 1.17
NAcc mRNA stability 0 0 1.16
OFC alternative polyA 0 0 1.05
OFC alternative TSS 0 0 1.25
OFC gene expression 0 0 1.13
OFC isoform ratio 0 0 1.11
OFC intron excision ratio 0 0 1.03
OFC mRNA stability 0 0 1.21
PL alternative polyA 0 0 1.1
PL alternative TSS 0 0 1.14
PL gene expression 0 0 1.14
PL isoform ratio 0 0 1.11
PL intron excision ratio 0 0 1.11
PL mRNA stability 0 0 1.13
pVTA alternative polyA 0 0 1.08
pVTA alternative TSS 0 0 1.17
pVTA gene expression 0 0 1.13
pVTA isoform ratio 0 0 1.09
pVTA intron excision ratio 0 0 1.15
pVTA mRNA stability 0 0 1.16
RMTg alternative polyA 0 0 1.05
RMTg alternative TSS 0 0 1.28
RMTg gene expression 0 0 1.12
RMTg isoform ratio 0 0 1.21
RMTg intron excision ratio 0 0 1.26
RMTg mRNA stability 0 0 1.04