Hub : Genes

Ndufb9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Ndufb9	0.33	0.2	2.7e-03	0.01	0.01	0.01	0.01	3.4e-02	1.1e-02	8.5e-03	1.6e-02
2	Brain	gene expression	Ndufb9	0.03	0.03	1.8e-03	0.02	0.02	0.02	0.02	5.8e-03	8.7e-03	6.5e-03	1.2e-02
3	Brain	intron excision ratio	chr7_92370606_92373029	0.03	0.03	4.7e-03	0.02	0.02	0.01	0.01	6.2e-03	1.1e-02	3.8e-02	1.6e-02
4	pVTA	intron excision ratio	chr7_92370606_92373029	0.06	0.07	1.1e-04	0.05	0.05	0.04	0.06	9.4e-05	4.3e-05	2.0e-04	3.1e-05
5	Brain	mRNA stability	Ndufb9	0.06	0.06	1.3e-05	0.05	0.05	0.06	0.05	3.7e-05	1.5e-05	7.0e-06	2.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.4	4.2	17.5	4.2	-0.9	-0.9	-0.9	0.9
Area under the delay curve	0.5	0.6	2.0	1.4	0.5	0.5	0.5	-0.5
BMI with tail	5.7	19.5	42.0	6.5	-3.8	-3.8	-3.7	3.7
BMI without tail	3.7	11.3	46.8	6.8	-1.6	-1.6	-1.5	1.5
Body weight	4.3	18.7	60.7	7.8	-2.9	-2.9	-2.8	2.8
Weight adjusted by age	10.7	16.2	77.8	8.8	-0.9	-0.9	-0.8	0.9
Bone surface	0.6	1.1	5.0	2.2	0.3	0.3	0.3	-0.3
Bone volume	0.4	0.7	2.3	1.5	0.5	0.5	0.5	-0.5
Breakpoint value in progressive ratio session	1.3	1.5	2.3	-1.5	1.2	1.2	1.2	-1.2
Number of licking bursts	1.0	1.7	1.9	-1.0	1.4	1.4	1.4	-1.4
Context. condit. distance diff. score	0.6	0.8	1.5	-1.2	-0.8	-0.8	-0.8	0.8
Locomotion velocity, session 1	3.2	3.5	16.9	-4.1	-0.3	-0.3	-0.3	0.3
Locomotion distance, session 1	0.1	0.2	0.5	0.7	-0.3	-0.3	-0.3	0.3
Locomotion velocity, session 2	0.8	1.0	1.2	-0.2	-1.1	-1.1	-1.1	1.1
Locomotion distance, session 2	0.2	0.2	0.8	0.9	-0.3	-0.3	-0.3	0.3
Locomotion velocity, session 3	0.6	0.7	0.7	-0.7	0.8	0.8	0.8	-0.8
Locomotion distance, session 3	0.4	0.5	0.7	-0.8	0.6	0.6	0.6	-0.6
Stereotopy head waving bouts, day 3	1.7	2.0	3.7	1.9	-1.2	-1.2	-1.2	1.2
Stereotopy head waving duration, day 3	1.0	1.1	5.2	2.3	-0.4	-0.4	-0.4	0.4
Locomotion velocity, session 7	1.1	1.2	1.4	0.7	1.2	1.2	1.2	-1.2
Locomotion distance, session 7	6.1	7.7	17.6	-4.2	2.3	2.3	2.3	-2.3
Stereotopy head waving bouts, day 7	10.0	11.3	55.2	7.4	-0.6	-0.6	-0.6	0.6
Stereotopy head waving duration, day 7	9.4	11.3	56.3	7.5	-0.0	-0.0	-0.0	0.0
Locomotion velocity, session 8	1.1	1.4	1.7	0.3	-1.3	-1.3	-1.3	1.3
Locomotion distance, session 8	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	-0.1
Degree of sensitization distance	1.1	1.2	1.4	-0.5	1.2	1.2	1.2	-1.2
Degree of sensitization stereotypy	3.4	3.6	17.7	4.2	0.4	0.4	0.4	-0.4
Conditioned locomotion	3.0	3.5	4.0	-1.2	2.0	2.0	2.0	-2.0
Cocaine response after cond. corrected	0.7	0.9	4.3	2.1	-0.0	-0.0	0.0	0.0
Cocaine response after cond. not corrected	0.7	0.8	3.5	1.9	-0.4	-0.4	-0.4	0.4
Cocaine response before conditioning	0.8	1.0	1.2	-0.3	-1.1	-1.1	-1.1	1.1
Saline control response	0.1	0.2	0.8	-0.9	-0.2	-0.2	-0.2	0.2
Bone: connectivity density	3.5	5.4	25.2	5.0	-0.7	-0.7	-0.7	0.7
Bone: cortical apparent density	3.9	5.3	11.4	-3.4	2.0	2.0	2.0	-2.0
Bone: cortical area	1.2	1.8	9.0	3.0	0.1	0.1	0.1	-0.1
Bone: cortical porosity	2.8	3.1	11.5	3.4	-1.0	-1.0	-1.0	1.0
Bone: cortical porosity	2.4	2.6	8.6	2.9	-1.1	-1.1	-1.1	1.1
Bone: cortical thickness	1.8	2.9	13.0	3.6	-0.6	-0.6	-0.6	0.6
Bone: cortical thickness	2.3	2.7	13.2	3.6	-0.2	-0.2	-0.2	0.2
Bone: cortical tissue density	4.2	5.7	12.7	-3.6	2.0	2.0	2.0	-2.0
Condit. Reinf. active minus inactive responses	0.3	0.4	0.4	-0.6	-0.6	-0.6	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	2.7	1.7	-0.5	-0.5	-0.5	0.5
Condit. Reinf. active responses	0.8	1.0	2.9	-1.7	-0.8	-0.8	-0.8	0.8
Condit. Reinf. inactive responses	2.9	3.6	16.7	-4.1	-0.6	-0.6	-0.6	0.6
Incentive salience index mean	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.3	0.3
Condit. Reinf. lever presses	0.2	0.2	0.9	1.0	0.2	0.2	0.2	-0.2
Condit. Reinf. active minus inactive responses	1.9	2.5	4.8	2.2	-1.4	-1.4	-1.4	1.4
Condit. Reinf. active-inactive response ratio	1.6	1.8	8.5	2.9	-0.4	-0.4	-0.4	0.4
Condit. Reinf. active responses	1.9	2.7	2.7	1.6	-1.6	-1.6	-1.6	1.6
Condit. Reinf. inactive responses	1.1	1.4	3.5	-1.9	-0.9	-0.9	-0.9	0.9
Condit. Reinf. lever presses	2.2	3.1	9.0	3.0	-1.3	-1.3	-1.3	1.3
Condit. Reinf. lever reinforcers received	1.7	2.4	3.7	1.9	-1.4	-1.4	-1.4	1.4
Conditioned reinforcement - actives	9.5	16.2	79.5	8.9	-0.6	-0.6	-0.6	0.6
Conditioned reinforcement - inactives	9.4	13.8	65.2	8.1	1.0	1.0	1.0	-1.0
Conditioned locomotion	14.4	18.7	92.5	9.6	-0.5	-0.5	-0.5	0.5
Patch foraging indifference point 0 sec	0.9	1.6	4.4	2.1	-0.9	-0.9	-1.0	1.0
Patch foraging indifference point AUC	3.4	4.9	23.8	-4.9	0.5	0.5	0.5	-0.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	0.9	0.1	0.1	0.1	-0.1
Delay disc. indifference point, 16s delay	2.0	2.2	2.2	-1.4	1.5	1.5	1.5	-1.5
Delay disc. indifference point, 2s delay	1.1	1.2	2.3	1.5	-1.0	-1.0	-0.9	1.0
Delay disc. indifference point, 24s delay	0.2	0.3	1.2	1.1	0.2	0.2	0.2	-0.2
Delay disc. indifference point, 4s delay	3.3	3.4	16.1	4.0	-0.5	-0.5	-0.5	0.5
Delay disc. indifference point, 8s delay	0.5	0.6	0.6	-0.8	0.8	0.8	0.8	-0.8
Indifference point function ln k	12.3	21.5	100.4	10.0	-1.3	-1.3	-1.4	1.3
Indifference point function log k	12.3	21.5	100.4	10.0	-1.3	-1.3	-1.4	1.3
Patch foraging total patch changes 0 sec	0.4	0.7	2.1	1.5	-0.6	-0.6	-0.6	0.6
Patch foraging total patch changes 12 sec	10.1	13.0	60.6	-7.8	1.1	1.1	1.1	-1.1
Patch foraging total patch changes 18 sec	2.5	3.9	18.7	-4.3	-0.4	-0.4	-0.4	0.4
Patch foraging total patch changes 24 sec	19.1	32.7	162.8	-12.8	0.4	0.4	0.5	-0.5
Patch foraging total patch changes 6 sec	3.8	5.8	28.8	-5.4	0.3	0.3	0.3	-0.3
Patch foraging time to switch 0 sec	4.3	8.8	42.3	-6.5	0.7	0.7	0.7	-0.7
Patch foraging water rate 0 sec	3.1	6.5	24.5	4.9	-1.4	-1.4	-1.4	1.4
Patch foraging water rate 12 sec	0.3	0.6	1.2	-1.1	-0.6	-0.6	-0.7	0.6
Patch foraging water rate 18 sec	1.7	2.6	8.4	2.9	-1.0	-1.0	-1.1	1.0
Patch foraging water rate 24 sec	0.2	0.2	0.4	0.0	-0.5	-0.5	-0.6	0.6
Patch foraging water rate 6 sec	7.2	10.6	47.1	6.9	-1.2	-1.2	-1.3	1.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	-0.6	0.4	0.4	0.2	-0.4
Distance traveled before self-admin	2.0	2.6	12.4	3.5	0.4	0.4	0.5	-0.4
Distance traveled after self-admin	1.1	1.4	6.2	-2.5	-0.4	-0.4	-0.4	0.4
Extensor digitorum longus weight	2.3	9.2	11.3	-1.0	-3.4	-3.4	-3.4	3.3
Bone: elastic displacement	3.0	3.4	4.2	0.5	-2.1	-2.1	-2.1	2.1
Bone: elastic work	1.8	2.4	3.0	0.0	-1.7	-1.7	-1.7	1.7
Bone: endosteal estimation	2.1	4.6	15.5	-3.9	1.4	1.4	1.4	-1.4
Bone: endosteal perimeter	0.3	0.6	0.7	0.5	0.8	0.8	0.8	-0.8
Epididymis fat weight	1.4	4.7	23.3	4.8	0.3	0.3	0.3	-0.3
Delta time in closed arm before/after self-admin	2.1	1.9	7.9	-2.8	-0.7	-0.7	-0.6	0.7
Delta time in open arm before/after self-admin	1.9	1.9	5.2	2.3	1.0	1.0	1.0	-1.0
Diff in mean of infusions in LGA sessions	1.3	1.6	8.0	2.8	-0.2	-0.2	-0.2	0.2
Delay discount exponential model param	0.6	0.6	2.5	-1.6	-0.4	-0.4	-0.4	0.4
Extinction: sum of active levers before priming	9.0	9.9	43.9	-6.6	1.2	1.2	1.1	-1.2
Active lever presses in extinction session 6	1.5	1.5	3.9	2.0	1.0	1.0	1.0	-1.0
Bone: final force	1.0	1.6	3.0	1.7	-1.1	-1.1	-1.1	1.1
Bone: final moment	0.4	0.6	0.9	0.9	-0.8	-0.8	-0.8	0.8
Food consumed during 24 hour testing period	0.3	0.4	0.6	-0.8	-0.6	-0.6	-0.6	0.6
Glucose	2.9	4.5	9.7	3.1	1.8	1.8	1.8	-1.7
Heart weight	1.9	2.9	12.2	3.5	-0.8	-0.8	-0.7	0.8
Delay discount hyperbolic model param	0.4	0.5	2.2	-1.5	-0.2	-0.2	-0.2	0.1
Intermittent access intake day 1-15 change	0.4	0.8	1.0	-0.3	1.0	1.0	0.9	-1.0
Intermittent access intake escalation	0.2	0.5	0.6	0.5	0.8	0.8	0.7	-0.8
Intermittent access intake escalation 2	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.1
Intermitt. access day 1 inactive lever presses	1.2	4.7	23.3	4.8	0.2	0.2	0.2	-0.2
Intermitt. access day 15 inactive lever presses	25.6	52.5	262.4	16.2	0.1	0.1	-0.0	-0.0
Intermitt. access escalation Index	1.9	2.8	13.5	3.7	-0.2	-0.2	-0.2	0.3
Intermittent access day 1 total infusions	0.8	1.3	1.8	-0.2	1.3	1.3	1.3	-1.3
Intermittent access day 15 total infusions	1.5	2.2	3.3	-1.8	1.4	1.4	1.4	-1.4
Intermittent access terminal intake (last 3 days)	2.1	2.7	3.4	-0.1	1.8	1.8	1.8	-1.8
Intermittent access total infusions	1.7	2.0	2.6	0.1	1.6	1.6	1.6	-1.6
Intermittent access day 1 locomotion	0.1	0.2	0.4	0.6	0.3	0.3	0.4	-0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.3	0.2	0.5	0.5	0.5	-0.5
Intermittent access total locomotion	2.4	2.8	14.1	3.7	0.1	0.1	0.0	-0.1
Intermittent access standard deviation	1.5	3.1	5.3	2.3	1.6	1.6	1.5	-1.6
Left kidney weight	2.3	10.7	43.4	6.6	-1.6	-1.6	-1.6	1.6
Right kidney weight	3.1	14.1	60.6	7.8	-1.6	-1.6	-1.6	1.6
Cocaine induced anxiety	17.9	25.5	117.0	-10.8	1.6	1.6	1.6	-1.7
Post-drug Anxiety	7.5	8.1	28.7	-5.4	1.7	1.7	1.7	-1.7
Baseline Anxiety	39.8	46.1	230.6	15.2	0.2	0.2	0.3	-0.1
Tail length	0.9	3.7	6.6	2.6	1.7	1.7	1.7	-1.8
Length with tail	1.8	7.9	39.2	6.3	0.3	0.3	0.4	-0.4
Length without tail	1.9	6.1	24.3	4.9	-1.3	-1.3	-1.2	1.3
Times rat made contact with spout	3.4	3.8	13.3	-3.6	1.2	1.2	1.2	-1.2
Lifetime Intake	1.7	2.0	2.4	0.9	1.5	1.5	1.5	-1.5
Liver weight, left	1.7	2.8	11.8	-3.4	-0.8	-0.8	-0.7	0.8
Liver weight, right	2.6	4.5	9.4	3.1	-1.8	-1.8	-1.8	1.8
Locomotor activity	2.2	3.5	6.4	2.5	-1.7	-1.7	-1.7	1.6
Locomotor testing distance	3.0	5.5	24.8	5.0	-0.8	-0.8	-0.8	0.8
Locomotor testing rearing	1.0	2.0	9.5	3.1	-0.4	-0.4	-0.4	0.4
Locomotion in novel chamber	18.6	23.8	106.4	10.3	-1.8	-1.8	-1.7	1.8
Locomotion in novel chamber post-restriction	1.5	2.5	12.2	-3.5	-0.1	-0.1	-0.1	0.1
Fecal boli incidents, locomotor time 1	2.8	4.1	4.5	-1.7	2.1	2.1	2.1	-2.1
Change in fecal boli incidents, locomotor task	5.9	5.8	28.6	-5.3	-0.4	-0.4	-0.4	0.4
Time >=10cm from walls, locomotor time 1	1.4	1.5	7.4	-2.7	-0.1	-0.1	-0.2	0.1
Bouts of movement, locomotor time 1	4.9	5.6	6.6	2.6	2.3	2.3	2.3	-2.3
Total resting periods, locomotor time 1	3.6	4.0	4.5	1.5	2.1	2.1	2.1	-2.1
Rest time, locomotor task time 1	7.4	9.2	22.5	4.7	2.4	2.4	2.5	-2.4
Distance moved, locomotor task time 1	14.1	21.1	98.6	-9.9	-1.3	-1.3	-1.3	1.3
Vertical activity count, locomotor time 1	1.4	3.4	3.9	-1.5	-1.9	-1.9	-2.0	1.9
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.4	-0.6	0.6	0.6	0.5	-0.6
Bouts of movement, locomotor time 2	1.6	2.6	4.8	-2.2	1.4	1.4	1.4	-1.4
Total resting periods, locomotor time 2	1.2	2.1	2.4	-1.6	1.4	1.4	1.4	-1.4
Rest time, locomotor task time 2	3.0	3.8	12.0	3.5	1.3	1.3	1.3	-1.3
Distance moved, locomotor task time 2	1.6	1.9	6.5	-2.6	-0.8	-0.8	-0.8	0.8
Vertical activity count, locomotor time 2	1.0	1.3	1.4	1.1	-1.2	-1.2	-1.1	1.2
Light reinforcement 1	0.0	0.0	0.1	-0.3	0.0	0.0	0.1	-0.0
Light reinforcement 2	1.5	2.3	7.4	2.7	1.0	1.0	1.0	-1.0
Bone: marrow area	2.1	4.6	16.3	-4.0	1.3	1.3	1.3	-1.3
Bone: maximum diameter	1.4	2.7	10.7	3.3	0.8	0.8	0.8	-0.8
Bone: maximum force	0.3	0.6	2.2	-1.5	-0.5	-0.5	-0.5	0.5
Bone: maximum moment	0.8	1.3	6.6	-2.6	-0.0	-0.0	-0.0	0.0
Mean time between licks in bursts	1.1	2.7	9.4	-3.1	1.0	1.0	1.0	-1.0
Mean num. licks in bursts	0.4	0.6	1.7	-1.3	-0.6	-0.6	-0.6	0.6
Cd content in liver	3.7	4.1	6.0	2.4	-1.9	-1.9	-1.9	1.9
Co content in liver	0.7	0.8	1.3	-1.1	-0.8	-0.8	-0.8	0.7
Cu content in liver	3.3	3.9	19.3	4.4	-0.3	-0.3	-0.3	0.3
Fe content in liver	0.4	0.5	2.2	-1.5	0.2	0.2	0.2	-0.2
K content in liver	1.0	1.0	1.3	0.4	1.1	1.1	1.1	-1.1
Mg content in liver	1.4	1.4	3.1	-1.8	1.0	1.0	1.0	-1.1
Mn content in liver	13.1	14.5	72.2	-8.5	-0.3	-0.3	-0.3	0.2
Na content in liver	2.1	2.3	10.0	-3.2	0.6	0.6	0.6	-0.6
Rb content in liver	11.5	13.4	63.1	-7.9	0.9	0.9	0.9	-1.1
Se content in liver	1.9	2.3	10.2	3.2	-0.5	-0.5	-0.5	0.6
Sr content in liver	0.3	0.3	0.3	0.5	-0.5	-0.5	-0.5	0.5
Zn content in liver	6.2	6.9	32.6	5.7	-0.7	-0.7	-0.7	0.7
Bone: minimum diameter	1.1	2.0	2.4	0.6	1.5	1.5	1.5	-1.5
Time in familiar zone, hab. session 1	0.7	0.7	3.3	-1.8	-0.2	-0.2	-0.2	0.2
Time in novel zone, hab. session 1	0.6	0.6	0.6	-0.7	0.7	0.7	0.7	-0.7
Total zone transitions, hab. session 1	5.0	7.0	19.1	4.4	-2.0	-2.0	-2.0	2.0
Total locomotion distance, hab. session 1	3.2	4.6	5.0	2.2	-2.1	-2.1	-2.1	2.1
Locomotion velocity, hab. session 1	2.1	3.0	4.8	2.2	-1.6	-1.6	-1.6	1.6
Time in familiar zone, hab. session 2	1.1	1.2	1.5	-0.5	1.2	1.2	1.2	-1.2
Time in novel zone, hab. session 2	0.8	0.8	1.0	-0.4	-1.0	-1.0	-1.0	1.0
Total zone transitions, hab. session 2	1.6	2.1	9.5	3.1	-0.5	-0.5	-0.5	0.5
Total locomotion distance, hab. session 2	0.5	0.7	1.3	1.1	-0.7	-0.7	-0.7	0.7
Locomotion velocity, hab. session 2	0.4	0.6	1.6	1.3	-0.6	-0.6	-0.6	0.6
Novel to familiar place preference ratio	0.3	0.3	0.4	-0.0	-0.6	-0.6	-0.6	0.6
Novelty place preference	0.7	0.7	0.7	-0.8	-0.9	-0.9	-0.9	0.9
Time in novel zone, NPP test	0.6	0.6	0.7	-0.8	-0.8	-0.8	-0.8	0.8
Total zone transitions, NPP test	5.9	8.5	37.5	6.1	-1.1	-1.1	-1.1	1.1
Total locomotion distance, NPP test	1.4	1.9	2.0	1.3	-1.4	-1.4	-1.4	1.4
Locomotion velocity, NPP test	1.2	1.7	1.8	1.2	-1.3	-1.3	-1.3	1.3
Intraocular pressure	1.0	1.4	6.5	2.5	-0.3	-0.3	-0.3	0.3
Delta distance traveled before/after self-admin	6.4	6.8	32.6	-5.7	-0.6	-0.6	-0.6	0.6
Delta ambulatory time before/after self-admin	1.9	2.4	11.3	-3.4	-0.4	-0.4	-0.4	0.4
Parametrial fat weight	0.5	1.1	1.2	1.0	-1.0	-1.0	-1.1	1.0
Pavlov. Cond. lever latency	3.9	4.9	6.8	-2.6	-2.1	-2.1	-2.1	2.1
Pavlov. Cond. magazine entry latency	1.8	2.3	2.6	-1.1	1.6	1.6	1.6	-1.6
Pavlov. Cond. change in total contacts	2.1	2.2	4.6	2.1	1.3	1.3	1.3	-1.3
Pavlov. Cond. index score	3.3	4.2	5.2	-0.3	2.3	2.3	2.3	-2.3
Pavlov. Cond. latency score	3.5	4.4	5.4	0.9	2.3	2.3	2.3	-2.3
Pavlov. Cond. lever contacts	5.1	6.1	13.5	3.7	2.1	2.1	2.1	-2.1
Pavlov. Cond. magazine entry number	1.2	1.5	1.7	0.7	-1.3	-1.3	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	5.4	6.4	17.8	-4.2	-1.9	-1.9	-1.9	1.9
Pavlov. Cond. lever-magazine prob. diff.	3.2	3.9	4.8	-0.4	2.2	2.2	2.2	-2.2
Pavlov. Cond. response bias	1.9	2.4	2.6	1.3	1.6	1.6	1.6	-1.6
Pavlov. Cond. lever latency	0.2	0.3	1.3	-1.1	0.2	0.2	0.2	-0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	1.3	-1.1	-0.4	-0.4	-0.4	0.4
Pavlov. Cond. change in total contacts	1.8	2.9	10.8	3.3	-0.9	-0.9	-0.9	0.9
Pavlov. Cond. index score	0.2	0.3	1.2	1.1	-0.2	-0.2	-0.2	0.2
Pavlov. Cond. latency score	0.4	0.6	1.4	1.2	-0.6	-0.6	-0.6	0.6
Pavlov. Cond. lever contacts	0.2	0.3	1.4	1.2	0.1	0.1	0.1	-0.1
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	-1.0	0.5	0.5	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.4	-0.5	0.6	0.6	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.5	1.2	-0.1	-0.1	-0.1	0.1
Pavlov. Cond. response bias	0.1	0.1	0.4	0.6	0.1	0.1	0.1	-0.1
Time in closed arm before self-admin	0.9	1.1	5.4	2.3	0.2	0.2	0.1	-0.2
Time in closed arm after self-admin	0.4	0.5	0.6	0.0	0.8	0.8	0.7	-0.8
Time in open arm before self-admin	15.6	17.0	75.8	8.7	-1.5	-1.5	-1.5	1.5
Time in open arm after self-admin	9.2	10.1	49.0	7.0	-0.6	-0.6	-0.6	0.6
Bone: periosteal estimation	0.8	1.6	1.9	-1.4	1.2	1.2	1.2	-1.2
Bone: periosteal perimeter	1.1	1.9	3.7	1.9	1.2	1.2	1.2	-1.2
Bone: post-yield work	1.5	2.2	3.1	-1.8	1.4	1.4	1.4	-1.4
Progressive ratio test 1 active lever presses	3.6	4.4	15.8	4.0	1.3	1.3	1.2	-1.2
Progressive ratio test 1 breakpoint	4.6	5.6	20.9	4.6	1.4	1.4	1.3	-1.3
Progressive ratio test 1 inactive lever presses	5.9	8.5	42.7	6.5	0.0	0.0	-0.1	0.0
Progressive ratio test 2 active lever presses	1.8	2.1	8.2	2.9	0.7	0.7	0.8	-0.7
Progressive ratio test 2 breakpoint	1.5	1.7	6.9	2.6	0.6	0.6	0.7	-0.6
Progressive ratio test 2 inactive lever presses	1.5	2.4	8.3	2.9	1.0	1.0	0.9	-1.0
Incentive Sensitization - Responses	7.5	10.5	52.6	7.3	0.1	0.1	0.1	-0.1
Incentive Sensitization - Breakpoint	5.2	6.8	33.5	5.8	0.3	0.3	0.3	-0.3
Sum of active levers in priming session hrs 5-6	2.9	2.7	12.9	-3.6	-0.4	-0.4	-0.4	0.4
Progressive ratio	9.1	14.3	71.1	-8.4	-0.2	-0.2	-0.2	0.2
Food seeking constrained by brief footshock	1.8	2.2	10.2	3.2	0.5	0.5	0.5	-0.5
Seeking ratio, punishment vs. effort	4.9	7.0	34.5	5.9	0.4	0.4	0.3	-0.4
Retroperitoneal fat weight	1.6	6.8	7.7	1.9	-2.7	-2.7	-2.8	2.8
Reaction time number correct	3.6	6.9	33.1	5.8	0.7	0.7	0.6	-0.5
Reaction time mean minus median	1.0	2.5	10.7	-3.3	0.6	0.6	0.7	-0.6
Reaction time mean minus median AUC	3.2	8.1	39.0	-6.2	0.7	0.7	0.7	-0.6
Reaction time num false alarms	0.6	0.8	1.0	-1.0	0.9	0.9	0.8	-1.0
Reaction time num false alarms AUC	0.5	0.8	1.2	0.3	1.0	1.0	0.9	-1.1
Reaction time trials correct on left	3.6	6.9	33.1	5.8	0.7	0.7	0.6	-0.5
Reaction time trials on left	3.4	6.4	30.3	5.5	0.7	0.7	0.6	-0.5
Reaction time mean	0.3	0.5	2.2	-1.5	0.2	0.2	0.2	-0.2
Reaction time mean AUC	0.6	1.0	4.4	-2.1	0.3	0.3	0.4	-0.3
Median of all reaction times	0.2	0.3	0.6	-0.8	0.4	0.4	0.4	-0.4
Reaction time omissions	2.0	2.9	10.6	-3.3	1.0	1.0	1.0	-1.0
Reaction time false alarm rate	1.2	1.7	7.9	-2.8	0.3	0.3	0.3	-0.4
Reaction time premature initiation rate	4.2	5.8	7.5	-0.4	-2.7	-2.7	-2.7	2.6
Reaction time premature initiations	2.1	3.7	6.2	2.5	-1.7	-1.7	-1.8	1.7
Std. dev. reaction times	1.1	2.0	9.7	-3.1	-0.2	-0.2	-0.2	0.3
Reaction time trials completed	3.4	6.4	30.3	5.5	0.7	0.7	0.6	-0.5
Reaction time trials AUC	2.8	5.4	24.8	5.0	0.8	0.8	0.7	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.8	-0.9	-0.2	-0.2	-0.1	0.2
Run reversals in cocaine runway, males	20.9	21.0	105.1	10.2	-0.1	-0.1	-0.2	0.1
Latency to leave start box in cocaine runway	3.4	3.8	4.7	-1.1	2.1	2.1	2.2	-2.1
Latency to leave start box in cocaine runway, F	8.1	9.3	29.7	-5.4	2.0	2.0	2.1	-2.0
Latency to leave start box in cocaine runway, M	4.2	3.9	16.9	4.1	0.8	0.8	0.9	-0.8
Std. dev. time between licks in bursts	0.9	1.2	3.3	-1.8	-0.8	-0.8	-0.8	0.8
Total sessions with >9 infusions	1.1	1.3	1.5	1.2	1.2	1.2	1.1	-1.1
Short access day 1 total inactive lever presses	6.7	8.8	40.3	6.3	1.0	1.0	0.8	-0.9
Short access day 10 total inactive lever presses	0.0	0.1	0.3	-0.6	0.1	0.1	-0.1	-0.1
Short access day 1 total infusions	0.3	0.5	0.6	0.5	0.7	0.7	0.6	-0.7
Short access day 10 total infusions	6.0	7.7	29.5	5.4	1.5	1.5	1.5	-1.5
Short access total infusions	1.3	1.7	2.7	1.7	1.2	1.2	1.1	-1.2
Short access day 1 locomotion	8.2	10.2	50.9	7.1	-0.1	-0.1	-0.2	0.2
Short access day 10 total locomotion	0.3	0.6	0.7	-0.3	0.8	0.8	0.8	-0.9
Short access total locomotion	1.8	2.1	10.2	3.2	-0.3	-0.3	-0.3	0.3
One hour access (0.3 mA shock)	1.4	1.6	7.5	2.7	-0.4	-0.4	-0.4	0.4
Compulsive drug intake	4.6	5.4	15.0	-3.9	-1.7	-1.7	-1.8	1.7
One hour access (shock baseline)	1.0	1.5	4.6	2.2	0.8	0.8	0.9	-0.8
Social response proportion	4.2	4.7	5.2	-1.8	-2.3	-2.3	-2.2	2.3
Social responses	6.8	8.8	9.2	-2.8	-3.0	-3.0	-2.9	3.0
Social time	2.6	3.6	4.0	-2.0	-1.9	-1.9	-1.9	1.9
Soleus weight	1.6	4.8	13.4	-3.7	-1.6	-1.6	-1.6	1.6
Bone: stiffness	0.4	0.6	2.7	1.6	0.2	0.2	0.2	-0.2
Tibialis anterior weight	2.6	8.8	10.6	1.3	-3.2	-3.2	-3.2	3.3
Time to tail flick, vehicle, before self-admin	2.3	2.3	10.7	-3.3	-0.5	-0.5	-0.5	0.5
Time to tail flick, vehicle, after self-admin	4.0	5.3	25.6	-5.1	0.5	0.5	0.5	-0.5
Time to tail flick, test, before self-admin	9.9	10.3	49.3	7.0	0.7	0.7	0.6	-0.7
Time to tail flick, test, after self-admin	16.2	16.8	83.3	9.1	0.4	0.4	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.9	-1.0	0.1	0.1	0.1	-0.1
Delta time to tail flick, test, before/after SA	3.1	3.2	13.1	3.6	-0.8	-0.8	-0.8	0.8
Tibia length	1.3	3.6	9.7	3.1	-1.4	-1.4	-1.4	1.5
Ambulatory time before self-admin	0.1	0.1	0.1	-0.1	0.3	0.3	0.4	-0.3
Ambulatory time after self-admin	0.6	0.6	1.2	-1.1	-0.7	-0.7	-0.7	0.7
Bone: tissue strength	0.2	0.2	0.9	1.0	-0.1	-0.1	-0.1	0.1
Total heroin consumption	1.5	1.7	3.2	-1.8	1.2	1.2	1.2	-1.2
Bone: trabecular number	7.8	12.8	57.8	7.6	-1.3	-1.3	-1.3	1.3
Bone: trabecular spacing	5.9	7.8	32.7	-5.7	1.3	1.3	1.3	-1.3
Bone: trabecular thickness	0.9	1.1	1.9	1.4	-0.9	-0.9	-0.9	0.9
Bone: trabecular tissue density	5.2	7.7	33.6	-5.8	1.1	1.1	1.1	-1.1
Water consumed over 24 hours	0.6	0.8	3.7	-1.9	-0.3	-0.3	-0.3	0.3
Number of responses in last shaping day	1.5	1.6	4.4	2.1	1.0	1.0	1.0	-1.0