Hub : Traits

ShA early titration

The total sum of the number of infusions taken in the last hour of days 1-3 of short access

Tags: Behavior · Cocaine

Project: u01_olivier_george_cocaine

4 loci · 4 genes with independent associations · 4 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr7	92127461	93066096	1	1	3.75e-10	5.98e-01	1.0e+00	Ndufb9
2	chr8	117463629	118343328	1	1	3.43e-09	2.88e-01	1.0e+00	Mst1
3	chr9	83390749	84777604	1	1	0.00e+00	8.89e-02	1.0e+00	Retreg2
4	chr17	61510864	62906219	1	1	5.75e-22	1.80e-01	2.3e-02	Ccny

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	439.52	2	2	50	0	1.00e+00	Ndufb9 Retreg2
BMI without tail	19087.71	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Body weight	8.94	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Epididymis fat weight	9080.51	4	3	75	-1	5.44e-04	Ccny Mst1 Ndufb9 Retreg2
Glucose	226.07	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Heart weight	1536.76	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Left kidney weight	18352.54	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Right kidney weight	10109.45	4	4	100	1	1.94e-03	Ccny Mst1 Ndufb9 Retreg2
Tail length	9640.98	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Length with tail	501.6	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
Length without tail	11815.62	4	2	50	1	1.79e-03	Ccny Mst1 Ndufb9 Retreg2
Liver weight, left	880.75	4	2	50	1	6.83e-04	Ccny Mst1 Ndufb9 Retreg2
Liver weight, right	31.51	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Parametrial fat weight	181.56	1	1	25	0	1.00e+00	Retreg2
Retroperitoneal fat weight	1985.63	2	2	50	0	1.00e+00	Mst1 Retreg2
Intraocular pressure	5195.51	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Extensor digitorum longus weight	541.05	2	1	25	0	1.00e+00	Mst1 Retreg2
Soleus weight	9.26	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Tibialis anterior weight	580.28	2	1	25	0	1.00e+00	Mst1 Retreg2
Tibia length	265.42	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Number of licking bursts	67424.86	1	1	25	0	1.00e+00	Retreg2
Food consumed during 24 hour testing period	11843.69	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Times rat made contact with spout	41.61	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Mean time between licks in bursts	55817.09	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Mean num. licks in bursts	56750.08	1	1	25	0	1.00e+00	Retreg2
Std. dev. time between licks in bursts	14881.26	2	1	25	0	1.00e+00	Mst1 Retreg2
Water consumed over 24 hours	11394.32	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging indifference point 0 sec	19591.07	2	1	25	0	1.00e+00	Mst1 Retreg2
Patch foraging indifference point AUC	12566.41	4	3	75	1	1.92e-03	Ccny Mst1 Ndufb9 Retreg2
Indifference point function ln k	13972.7	4	4	100	-1	1.20e-03	Ccny Mst1 Ndufb9 Retreg2
Indifference point function log k	13972.7	4	4	100	-1	1.20e-03	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 0 sec	20977.37	2	1	25	0	1.00e+00	Mst1 Retreg2
Patch foraging total patch changes 12 sec	612.51	4	4	100	-1	4.52e-03	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 18 sec	10122.69	4	2	50	-1	3.12e-03	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 24 sec	18737.98	4	3	75	-1	4.01e-03	Ccny Mst1 Ndufb9 Retreg2
Patch foraging total patch changes 6 sec	1956.8	4	2	50	-1	2.02e-03	Ccny Mst1 Ndufb9 Retreg2
Patch foraging time to switch 0 sec	22171.85	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 0 sec	30219.01	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Patch foraging water rate 12 sec	23555.93	3	2	50	0	1.00e+00	Ccny Mst1 Retreg2
Patch foraging water rate 18 sec	11246.65	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Patch foraging water rate 24 sec	523.92	2	1	25	0	1.00e+00	Mst1 Retreg2
Patch foraging water rate 6 sec	297.7	3	3	75	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotor activity	16.04	3	1	25	0	1.00e+00	Ccny Mst1 Ndufb9
Locomotor testing distance	6934.02	4	3	75	0.99	8.29e-03	Ccny Mst1 Ndufb9 Retreg2
Locomotor testing rearing	21145.02	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Light reinforcement 1	22114.5	3	2	50	0	1.00e+00	Ccny Mst1 Retreg2
Light reinforcement 2	9210.73	4	3	75	1	9.62e-04	Ccny Mst1 Ndufb9 Retreg2
Reaction time number correct	21165.65	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean minus median	39986.09	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time mean minus median AUC	41341.25	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time num false alarms	7685.9	2	1	25	0	1.00e+00	Mst1 Retreg2
Reaction time num false alarms AUC	11677.34	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Reaction time trials correct on left	21165.65	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials on left	20303.42	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time mean	29724.21	1	1	25	0	1.00e+00	Retreg2
Reaction time mean AUC	38768	1	1	25	0	1.00e+00	Retreg2
Median of all reaction times	7893.84	1	1	25	0	1.00e+00	Retreg2
Reaction time omissions	2792.39	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time false alarm rate	76.38	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time premature initiation rate	9733.76	1	1	25	0	1.00e+00	Retreg2
Reaction time premature initiations	53743.58	1	1	25	0	1.00e+00	Retreg2
Std. dev. reaction times	20293.6	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Reaction time trials completed	20303.42	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Reaction time trials AUC	20718.27	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Social response proportion	4397.95	2	1	25	0	1.00e+00	Mst1 Retreg2
Social responses	323.05	4	1	25	1	1.45e-03	Ccny Mst1 Ndufb9 Retreg2
Social time	5828.31	2	1	25	0	1.00e+00	Mst1 Retreg2
Conditioned locomotion	1400.08	1	1	25	0	1.00e+00	Retreg2
Cocaine response after cond. corrected	19128.47	1	1	25	0	1.00e+00	Retreg2
Cocaine response after cond. not corrected	18571.31	1	1	25	0	1.00e+00	Retreg2
Cocaine response before conditioning	655.41	1	1	25	0	1.00e+00	Retreg2
Saline control response	1639.18	2	2	50	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active minus inactive responses	7271.32	2	2	50	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. active-inactive response ratio	14360.59	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Condit. Reinf. active responses	1165.18	2	2	50	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. inactive responses	5466.41	2	2	50	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	1311.07	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. lever reinforcers received	243.91	2	1	25	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever latency	1278.33	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry latency	6738.25	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. change in total contacts	19909.31	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Pavlov. Cond. index score	6407.33	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	8109.24	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	2689.72	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. magazine entry number	2097.69	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	17558.57	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	5938.34	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	641.31	2	2	50	0	1.00e+00	Mst1 Retreg2
Conditioned reinforcement - actives	33617.26	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Conditioned reinforcement - inactives	16265.43	4	3	75	-0.99	6.22e-03	Ccny Mst1 Ndufb9 Retreg2
Conditioned locomotion	2608.24	4	2	50	-1	2.54e-03	Ccny Mst1 Ndufb9 Retreg2
Intermittent access intake day 1-15 change	42631.78	3	2	50	0	1.00e+00	Ccny Mst1 Retreg2
Intermittent access intake escalation	63041.23	2	2	50	0	1.00e+00	Mst1 Retreg2
Intermittent access intake escalation 2	12071.47	3	2	50	0	1.00e+00	Ccny Mst1 Retreg2
Intermitt. access day 1 inactive lever presses	45173.91	4	2	50	-1	3.04e-03	Ccny Mst1 Ndufb9 Retreg2
Intermitt. access day 15 inactive lever presses	61868.22	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Intermitt. access escalation Index	31137.19	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Intermittent access day 1 total infusions	33063.01	2	1	25	0	1.00e+00	Mst1 Retreg2
Intermittent access day 15 total infusions	48731.91	1	1	25	0	1.00e+00	Retreg2
Intermittent access terminal intake (last 3 days)	24800.59	1	1	25	0	1.00e+00	Retreg2
Intermittent access total infusions	93.49	2	1	25	0	1.00e+00	Ccny Retreg2
Intermittent access day 1 locomotion	17487.55	2	1	25	0	1.00e+00	Ccny Retreg2
Intermittent access day 15 total locomotion	42786.58	2	2	50	0	1.00e+00	Ccny Retreg2
Intermittent access total locomotion	45.91	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Intermittent access standard deviation	38004.24	3	3	75	0	1.00e+00	Ccny Mst1 Retreg2
Cocaine induced anxiety	23063.21	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Post-drug Anxiety	1595.89	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Baseline Anxiety	11242.19	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Lifetime Intake	834.23	2	1	25	0	1.00e+00	Ccny Retreg2
Incentive Sensitization - Responses	23798.01	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Incentive Sensitization - Breakpoint	18436.14	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 active lever presses	10671	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 breakpoint	10109.49	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 1 inactive lever presses	20756.82	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
Progressive ratio test 2 active lever presses	5096.01	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 breakpoint	2856.35	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio test 2 inactive lever presses	18130.29	4	1	25	-1	2.58e-03	Ccny Mst1 Ndufb9 Retreg2
Total sessions with >9 infusions	678.23	3	3	75	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 1 total inactive lever presses	9884.94	4	3	75	1	4.48e-03	Ccny Mst1 Ndufb9 Retreg2
Short access day 10 total inactive lever presses	46316.52	3	3	75	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 1 total infusions	12825.11	3	2	50	0	1.00e+00	Ccny Mst1 Retreg2
Short access day 10 total infusions	7585.44	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
Short access total infusions	4403.04	2	2	50	0	1.00e+00	Ccny Retreg2
Short access day 1 locomotion	6216.13	4	2	50	-1	4.75e-03	Ccny Mst1 Ndufb9 Retreg2
Short access day 10 total locomotion	44094.34	2	1	25	0	1.00e+00	Mst1 Retreg2
Short access total locomotion	6239.96	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Compulsive drug intake	6234.79	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
One hour access (0.3 mA shock)	781.33	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
One hour access (shock baseline)	54988.81	1	1	25	0	1.00e+00	Retreg2
Number of responses in last shaping day	4550.18	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Context. condit. distance diff. score	212.47	1	1	25	0	1.00e+00	Retreg2
Locomotion velocity, session 1	1769.63	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Locomotion distance, session 1	516.6	2	1	25	0	1.00e+00	Ccny Retreg2
Locomotion velocity, session 2	1110.36	2	2	50	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 2	174.93	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Locomotion velocity, session 3	507.49	1	1	25	0	1.00e+00	Retreg2
Locomotion distance, session 3	4009.46	1	1	25	0	1.00e+00	Retreg2
Stereotopy head waving bouts, day 3	691.91	2	1	25	0	1.00e+00	Mst1 Retreg2
Stereotopy head waving duration, day 3	1446.08	2	1	25	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, session 7	210.64	2	2	50	0	1.00e+00	Mst1 Retreg2
Locomotion distance, session 7	342.68	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Stereotopy head waving bouts, day 7	1279.33	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Stereotopy head waving duration, day 7	1081.37	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Locomotion velocity, session 8	409.23	1	1	25	0	1.00e+00	Retreg2
Locomotion distance, session 8	147.88	1	1	25	0	1.00e+00	Retreg2
Degree of sensitization distance	1889.61	2	2	50	0	1.00e+00	Mst1 Retreg2
Degree of sensitization stereotypy	690.43	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Condit. Reinf. active minus inactive responses	957.65	1	1	25	0	1.00e+00	Retreg2
Condit. Reinf. active-inactive response ratio	242.03	1	1	25	0	1.00e+00	Retreg2
Condit. Reinf. active responses	2765.7	1	1	25	0	1.00e+00	Retreg2
Condit. Reinf. inactive responses	1569.87	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Incentive salience index mean	1780.77	2	1	25	0	1.00e+00	Mst1 Retreg2
Condit. Reinf. lever presses	2666.81	2	2	50	0	1.00e+00	Mst1 Retreg2
Time in familiar zone, hab. session 1	5593.23	2	1	25	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 1	4629.95	2	2	50	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 1	221.7	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, hab. session 1	394.1	1	1	25	0	1.00e+00	Retreg2
Locomotion velocity, hab. session 1	266.96	1	1	25	0	1.00e+00	Retreg2
Time in familiar zone, hab. session 2	2966.16	2	2	50	0	1.00e+00	Mst1 Retreg2
Time in novel zone, hab. session 2	3208.33	2	2	50	0	1.00e+00	Mst1 Retreg2
Total zone transitions, hab. session 2	28.15	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Total locomotion distance, hab. session 2	14.23	2	1	25	0	1.00e+00	Mst1 Retreg2
Locomotion velocity, hab. session 2	31.27	1	1	25	0	1.00e+00	Retreg2
Novel to familiar place preference ratio	5121.06	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Novelty place preference	7474.7	2	1	25	0	1.00e+00	Mst1 Retreg2
Time in novel zone, NPP test	5350.34	2	1	25	0	1.00e+00	Mst1 Retreg2
Total zone transitions, NPP test	980.79	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Total locomotion distance, NPP test	1687.31	1	1	25	0	1.00e+00	Retreg2
Locomotion velocity, NPP test	479.14	2	1	25	0	1.00e+00	Ccny Retreg2
Pavlov. Cond. lever latency	186.46	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. change in total contacts	522.83	2	1	25	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. index score	214.07	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. latency score	224.45	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. lever contacts	252.4	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. magazine entry number	250.94	2	1	25	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. intertrial magazine entries	60.1	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Pavlov. Cond. lever-magazine prob. diff.	223.77	2	2	50	0	1.00e+00	Mst1 Retreg2
Pavlov. Cond. response bias	303.26	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: apparent density	2735.95	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Bone surface	3109.3	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone volume	4317.38	2	1	25	0	1.00e+00	Mst1 Retreg2
Bone: connectivity density	564.06	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical apparent density	6014.36	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical area	1559.21	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	150.35	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical porosity	560.57	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Bone: cortical thickness	157.6	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical thickness	996.09	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: cortical tissue density	4339.01	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: elastic displacement	7604.03	1	1	25	0	1.00e+00	Retreg2
Bone: elastic work	195.81	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: endosteal estimation	2975.35	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: endosteal perimeter	5936.33	2	1	25	0	1.00e+00	Mst1 Retreg2
Bone: final force	840.18	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: final moment	146.88	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: marrow area	3148.45	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum diameter	2046.98	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: maximum force	4390.32	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: maximum moment	2024.32	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: minimum diameter	2061.38	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: periosteal estimation	4919.52	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: periosteal perimeter	5722.93	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: post-yield work	6843.13	2	1	25	0	1.00e+00	Mst1 Retreg2
Bone: stiffness	4554.23	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: tissue strength	2995.95	1	1	25	0	1.00e+00	Retreg2
Bone: trabecular number	5387.39	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Bone: trabecular spacing	2669.39	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
Bone: trabecular thickness	4257.4	2	2	50	0	1.00e+00	Mst1 Retreg2
Bone: trabecular tissue density	4866.8	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
LgA early post infusion interval	17807.67	3	3	75	0	1.00e+00	Ccny Ndufb9 Retreg2
LgA late post infusion interval	11653.15	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
LgA early loading	54570.01	2	1	25	0	1.00e+00	Ndufb9 Retreg2
LgA late loading	46428.54	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
LgA early average infusions	9746.6	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
LgA late average infusions	31550.62	2	2	50	0	1.00e+00	Ndufb9 Retreg2
LgA early timeout	12057.77	1	1	25	0	1.00e+00	Retreg2
LgA late timeout	19618.34	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
LgA early titration	31242.14	2	2	50	0	1.00e+00	Ndufb9 Retreg2
LgA late titration	22568.78	3	3	75	0	1.00e+00	Mst1 Ndufb9 Retreg2
LgA total infusion	13538.04	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
LgA PC1 addiction-like behavior	52579.61	2	2	50	0	1.00e+00	Ndufb9 Retreg2
ShA PR total presses	11213.89	2	1	25	0	1.00e+00	Ndufb9 Retreg2
LgA PR total presses	3281.01	2	2	50	0	1.00e+00	Ccny Retreg2
ShA early post infusion interval	8072.47	1	1	25	0	1.00e+00	Retreg2
ShA late post infusion interval	86.39	4	1	25	0.89	1.06e-01	Ccny Mst1 Ndufb9 Retreg2
ShA early loading	57.13	4	2	50	0.98	1.76e-02	Ccny Mst1 Ndufb9 Retreg2
ShA late loading	28379.36	2	1	25	0	1.00e+00	Ndufb9 Retreg2
ShA early average infusions	4887.59	4	4	100	1	2.15e-03	Ccny Mst1 Ndufb9 Retreg2
ShA late average infusions	4442.59	2	1	25	0	1.00e+00	Ndufb9 Retreg2
ShA early timeout	156.31	4	2	50	0.98	2.33e-02	Ccny Mst1 Ndufb9 Retreg2
ShA late timeout	9217.96	2	1	25	0	1.00e+00	Mst1 Retreg2
ShA late titration	3826.49	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
ShA total infusions	18638.92	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Shock compulsivity	58902.44	2	2	50	0	1.00e+00	Ccny Retreg2
Total infusions	9598.69	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Breakpoint value in progressive ratio session	18809.48	2	1	25	0	1.00e+00	Mst1 Retreg2
Distance traveled before self-admin	12640.31	4	1	25	-1	1.04e-03	Ccny Mst1 Ndufb9 Retreg2
Distance traveled after self-admin	16247.09	2	2	50	0	1.00e+00	Ccny Retreg2
Delta time in closed arm before/after self-admin	98.8	4	2	50	-0.89	1.14e-01	Ccny Mst1 Ndufb9 Retreg2
Delta time in open arm before/after self-admin	5049.67	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Diff in mean of infusions in LGA sessions	12226.72	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Extinction: sum of active levers before priming	7131.77	4	4	100	-1	2.91e-03	Ccny Mst1 Ndufb9 Retreg2
Active lever presses in extinction session 6	272.24	3	3	75	0	1.00e+00	Ccny Mst1 Retreg2
Delta distance traveled before/after self-admin	996.98	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Delta ambulatory time before/after self-admin	10288.96	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Time in closed arm before self-admin	8974	3	2	50	0	1.00e+00	Ccny Mst1 Retreg2
Time in closed arm after self-admin	1570.76	3	3	75	0	1.00e+00	Ccny Mst1 Retreg2
Time in open arm before self-admin	2213.9	4	3	75	0.98	1.55e-02	Ccny Mst1 Ndufb9 Retreg2
Time in open arm after self-admin	152.24	4	3	75	-0.84	1.63e-01	Ccny Mst1 Ndufb9 Retreg2
Sum of active levers in priming session hrs 5-6	496.26	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Time to tail flick, vehicle, before self-admin	3376.29	4	3	75	-1	5.56e-04	Ccny Mst1 Ndufb9 Retreg2
Time to tail flick, vehicle, after self-admin	14057.72	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Time to tail flick, test, before self-admin	2731.5	3	2	50	0	1.00e+00	Mst1 Ndufb9 Retreg2
Time to tail flick, test, after self-admin	377.49	4	2	50	-0.97	3.21e-02	Ccny Mst1 Ndufb9 Retreg2
Delta time to tail flick, vehicle, before/after SA	3305.45	3	3	75	0	1.00e+00	Ccny Mst1 Retreg2
Delta time to tail flick, test, before/after SA	5236.1	3	1	25	0	1.00e+00	Mst1 Ndufb9 Retreg2
Ambulatory time before self-admin	39445.74	2	1	25	0	1.00e+00	Ccny Retreg2
Ambulatory time after self-admin	8880.01	3	1	25	0	1.00e+00	Ccny Mst1 Retreg2
Total heroin consumption	134.58	2	2	50	0	1.00e+00	Ccny Retreg2
Area under the delay curve	24791.27	1	1	25	0	1.00e+00	Retreg2
Delay disc. indifference point, 0s delay	2159.25	1	1	25	0	1.00e+00	Retreg2
Delay disc. indifference point, 16s delay	10986.22	2	1	25	0	1.00e+00	Ccny Retreg2
Delay disc. indifference point, 2s delay	155.27	1	1	25	0	1.00e+00	Retreg2
Delay disc. indifference point, 24s delay	16227.16	2	1	25	0	1.00e+00	Ccny Retreg2
Delay disc. indifference point, 4s delay	162.94	4	1	25	1	2.29e-03	Ccny Mst1 Ndufb9 Retreg2
Delay disc. indifference point, 8s delay	33362.4	1	1	25	0	1.00e+00	Retreg2
Delay discount exponential model param	16922.54	1	1	25	0	1.00e+00	Retreg2
Delay discount hyperbolic model param	12277.65	1	1	25	0	1.00e+00	Retreg2
Fecal boli incidents, locomotor time 1	61202.36	1	1	25	0	1.00e+00	Retreg2
Change in fecal boli incidents, locomotor task	1914.03	3	3	75	0	1.00e+00	Ccny Ndufb9 Retreg2
Time >=10cm from walls, locomotor time 1	4342.59	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Bouts of movement, locomotor time 1	3607.99	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Total resting periods, locomotor time 1	1407.78	2	1	25	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 1	11183.83	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 1	22964.53	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Vertical activity count, locomotor time 1	142354.07	1	1	25	0	1.00e+00	Retreg2
Time >=10cm from walls, locomotor time 2	35582.77	2	1	25	0	1.00e+00	Ccny Retreg2
Bouts of movement, locomotor time 2	41025.7	2	2	50	0	1.00e+00	Ccny Retreg2
Total resting periods, locomotor time 2	49531.53	2	2	50	0	1.00e+00	Ccny Retreg2
Rest time, locomotor task time 2	12756.26	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Distance moved, locomotor task time 2	2835.6	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Vertical activity count, locomotor time 2	26786.04	2	1	25	0	1.00e+00	Ccny Retreg2
Weight adjusted by age	23619.48	3	3	75	0	1.00e+00	Ccny Ndufb9 Retreg2
Seeking ratio, delayed vs. immediate footshock	6729.38	2	1	25	0	1.00e+00	Ccny Retreg2
Locomotion in novel chamber	1330.8	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Locomotion in novel chamber post-restriction	21811.49	3	1	25	0	1.00e+00	Ccny Ndufb9 Retreg2
Progressive ratio	22651.13	3	3	75	0	1.00e+00	Ccny Ndufb9 Retreg2
Food seeking constrained by brief footshock	941.83	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Seeking ratio, punishment vs. effort	13770.59	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Run reversals in cocaine runway, females	9406.04	1	1	25	0	1.00e+00	Retreg2
Run reversals in cocaine runway, males	3884.61	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway	8153.9	2	1	25	0	1.00e+00	Ccny Retreg2
Latency to leave start box in cocaine runway, F	3596.44	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Latency to leave start box in cocaine runway, M	593.09	3	2	50	0	1.00e+00	Ccny Ndufb9 Retreg2
Co content in liver	1133.25	1	1	25	0	1.00e+00	Retreg2
Cu content in liver	28.08	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Fe content in liver	1344.53	1	1	25	0	1.00e+00	Retreg2
K content in liver	1519.62	1	1	25	0	1.00e+00	Retreg2
Mg content in liver	6026.97	1	1	25	0	1.00e+00	Retreg2
Mn content in liver	537.3	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Na content in liver	2013.84	2	1	25	0	1.00e+00	Ndufb9 Retreg2
Rb content in liver	71.08	2	2	50	0	1.00e+00	Ndufb9 Retreg2
Se content in liver	8.63	1	0	0	0	1.00e+00	Ndufb9
Zn content in liver	1887.46	2	2	50	0	1.00e+00	Ndufb9 Retreg2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.13
Adipose	alternative TSS	0	0	1.1
Adipose	gene expression	0	0	1.12
Adipose	isoform ratio	0	0	1.1
Adipose	intron excision ratio	0	0	0.99
Adipose	mRNA stability	1	0	1.08
BLA	alternative polyA	0	0	1.15
BLA	alternative TSS	0	0	1.04
BLA	gene expression	0	0	1.11
BLA	isoform ratio	0	0	1.05
BLA	intron excision ratio	0	0	1.05
BLA	mRNA stability	0	0	1.09
Brain	alternative polyA	0	0	1.14
Brain	alternative TSS	0	0	1.09
Brain	gene expression	0	0	1.12
Brain	isoform ratio	0	0	1.11
Brain	intron excision ratio	0	0	1.03
Brain	mRNA stability	0	0	1.12
Eye	alternative polyA	0	0	1.25
Eye	alternative TSS	0	0	1
Eye	gene expression	0	0	1.01
Eye	isoform ratio	0	0	1.06
Eye	intron excision ratio	0	0	1.01
Eye	mRNA stability	0	0	0.99
IC	alternative polyA	0	0	1.11
IC	alternative TSS	0	0	1.12
IC	gene expression	0	0	1.15
IC	isoform ratio	0	0	1.11
IC	intron excision ratio	0	0	1.03
IC	mRNA stability	0	0	1.12
IL	alternative polyA	0	0	1.08
IL	alternative TSS	0	0	1.06
IL	gene expression	0	0	1.13
IL	isoform ratio	0	0	1.13
IL	intron excision ratio	0	0	0.95
IL	mRNA stability	0	0	1.09
LHb	alternative polyA	0	0	1.12
LHb	alternative TSS	0	0	1.07
LHb	gene expression	0	0	1.08
LHb	isoform ratio	0	0	1.08
LHb	intron excision ratio	0	0	1.04
LHb	mRNA stability	0	0	1.09
Liver	alternative polyA	0	0	1.14
Liver	alternative TSS	0	0	1.07
Liver	gene expression	0	0	1.13
Liver	isoform ratio	1	0	1.11
Liver	intron excision ratio	0	0	1.1
Liver	mRNA stability	0	0	1.12
NAcc	alternative polyA	1	0	1.56
NAcc	alternative TSS	0	0	1.09
NAcc	gene expression	0	0	1.14
NAcc	isoform ratio	0	0	1.13
NAcc	intron excision ratio	0	0	1.07
NAcc	mRNA stability	0	0	1.12
OFC	alternative polyA	0	0	1.22
OFC	alternative TSS	0	0	1.04
OFC	gene expression	0	0	1.12
OFC	isoform ratio	0	0	1.17
OFC	intron excision ratio	0	0	1.04
OFC	mRNA stability	0	0	1.09
PL	alternative polyA	0	0	1.15
PL	alternative TSS	0	0	1.09
PL	gene expression	0	0	1.14
PL	isoform ratio	0	0	1.1
PL	intron excision ratio	0	0	1.07
PL	mRNA stability	0	0	1.15
pVTA	alternative polyA	0	0	1.18
pVTA	alternative TSS	0	0	1.12
pVTA	gene expression	1	0	1.13
pVTA	isoform ratio	0	0	1.11
pVTA	intron excision ratio	0	0	1.03
pVTA	mRNA stability	0	0	1.13
RMTg	alternative polyA	0	0	1.06
RMTg	alternative TSS	0	0	1.15
RMTg	gene expression	0	0	1.1
RMTg	isoform ratio	0	0	1.13
RMTg	intron excision ratio	0	0	1.04
RMTg	mRNA stability	0	0	1.1