Hub : Genes

Taf4

TATA-box binding protein associated factor 4

chr3:187395632–187461042 (-)

Taf4 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Taf4	0.04	0.03	2.7e-03	0.02	0.02	0.03	0.02	7.8e-03	1.1e-02	1.4e-03	2.4e-03
2	Brain	intron excision ratio	chr3_187422986_187459758	0.03	0.02	1.9e-03	0.03	0.02	0.02	0.02	1.0e-03	4.3e-03	3.4e-03	4.6e-03
3	Adipose	gene expression	Taf4	0.04	0.03	6.3e-06	0.05	0.04	0.03	0.05	6.3e-06	2.1e-05	9.5e-05	7.8e-06
4	Adipose	mRNA stability	Taf4	0.04	0.03	7.9e-05	0.04	0.03	0.03	0.03	5.5e-05	1.5e-04	1.1e-04	1.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.5	-0.4	0.7	-0.4	-0.4
Area under the delay curve	0.0	0.1	0.1	-0.1	-0.3	0.1	-0.2
BMI with tail	0.3	1.0	2.4	1.1	-0.5	0.5	1.6
BMI without tail	1.6	4.8	8.1	1.2	-2.2	2.2	2.8
Body weight	0.4	1.7	4.7	2.2	-0.6	0.5	1.3
Weight adjusted by age	0.4	0.6	0.9	0.9	0.9	-0.7	-0.5
Bone surface	1.6	3.0	4.2	-1.5	1.7	-1.6	-2.0
Bone volume	0.6	1.1	1.3	-1.0	1.1	-1.0	-1.1
Breakpoint value in progressive ratio session	2.2	2.6	8.2	2.9	-0.9	0.8	0.9
Number of licking bursts	1.1	1.8	2.6	-0.7	1.6	-1.5	-1.4
Context. condit. distance diff. score	1.3	1.6	2.3	-1.0	1.5	-1.1	-1.4
Locomotion velocity, session 1	0.2	0.2	0.7	0.2	0.8	-0.2	0.4
Locomotion distance, session 1	0.4	0.5	0.9	-0.5	0.3	0.8	1.0
Locomotion velocity, session 2	0.3	0.3	1.1	1.1	0.3	0.2	0.2
Locomotion distance, session 2	0.9	1.3	2.3	0.8	-0.5	1.4	1.5
Locomotion velocity, session 3	2.6	3.0	4.8	-1.9	2.2	-1.5	-1.2
Locomotion distance, session 3	0.4	0.5	0.8	0.0	-0.6	0.8	0.9
Stereotopy head waving bouts, day 3	2.9	3.4	5.5	-2.4	1.2	-2.0	-1.6
Stereotopy head waving duration, day 3	2.3	2.7	6.1	-2.5	0.8	-1.6	-1.3
Locomotion velocity, session 7	3.9	4.2	7.3	-1.3	2.7	-2.0	-1.9
Locomotion distance, session 7	0.9	1.1	1.6	-0.6	1.3	-1.1	-1.2
Stereotopy head waving bouts, day 7	0.7	0.7	2.1	-1.5	-0.9	0.2	-0.1
Stereotopy head waving duration, day 7	0.7	0.8	2.7	-1.7	0.0	-0.4	-0.7
Locomotion velocity, session 8	0.3	0.4	0.7	-0.8	0.9	-0.4	-0.3
Locomotion distance, session 8	0.2	0.3	0.8	-0.4	0.9	-0.1	-0.2
Degree of sensitization distance	3.3	3.4	4.7	-0.7	2.0	-2.0	-2.2
Degree of sensitization stereotypy	1.4	1.6	3.3	-0.3	-1.8	1.5	0.8
Conditioned locomotion	0.3	0.4	0.7	-0.5	0.4	-0.6	-0.8
Cocaine response after cond. corrected	0.4	0.4	1.2	-0.4	-1.1	0.6	-0.1
Cocaine response after cond. not corrected	0.2	0.2	0.4	-0.6	-0.5	0.0	-0.6
Cocaine response before conditioning	1.4	1.7	2.7	-0.1	1.6	-1.6	-1.3
Saline control response	0.3	0.3	0.6	0.7	0.8	0.2	0.5
Bone: connectivity density	0.4	0.7	1.1	-0.3	1.1	-0.9	-0.9
Bone: cortical apparent density	0.6	0.8	1.3	1.0	-0.5	1.1	0.8
Bone: cortical area	1.1	1.7	2.5	0.4	-1.5	1.6	1.3
Bone: cortical porosity	0.6	0.6	2.0	-1.4	-0.4	-0.0	-0.5
Bone: cortical porosity	0.5	0.6	2.1	-1.4	-0.4	-0.1	-0.4
Bone: cortical thickness	3.2	5.2	7.5	1.5	-2.3	2.7	2.5
Bone: cortical thickness	4.5	5.3	8.0	1.1	-2.7	2.8	2.3
Bone: cortical tissue density	0.4	0.6	0.9	0.9	-0.4	1.0	0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.3	-0.5	0.7	0.4
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.1	0.7	-0.6	1.0	0.6
Condit. Reinf. active responses	0.3	0.4	0.7	0.8	-0.4	0.6	0.6
Condit. Reinf. inactive responses	0.2	0.3	0.4	0.6	-0.5	0.3	0.6
Incentive salience index mean	1.2	1.5	2.0	1.1	-1.0	1.4	1.4
Condit. Reinf. lever presses	2.0	2.7	3.7	1.5	-1.4	1.8	1.9
Condit. Reinf. active minus inactive responses	0.4	0.5	1.8	1.3	0.0	-0.1	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.0	1.0	-0.7	0.6	0.9
Condit. Reinf. active responses	0.3	0.4	1.2	1.1	-0.4	0.1	0.5
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1
Condit. Reinf. lever presses	0.7	0.9	2.1	1.4	-0.7	0.6	0.8
Condit. Reinf. lever reinforcers received	0.4	0.6	1.3	1.1	-0.6	0.4	0.7
Conditioned reinforcement - actives	0.8	1.3	2.9	1.0	-1.7	1.0	0.7
Conditioned reinforcement - inactives	2.7	4.0	7.6	2.2	-2.7	1.5	1.2
Conditioned locomotion	0.8	1.0	2.0	0.4	-1.4	1.2	0.7
Patch foraging indifference point 0 sec	0.2	0.4	1.5	-0.5	1.2	-0.0	-0.0
Patch foraging indifference point AUC	0.5	0.7	1.9	1.4	-0.7	-0.1	0.3
Delay disc. indifference point, 0s delay	0.7	0.8	1.8	-1.1	-1.3	0.4	0.3
Delay disc. indifference point, 16s delay	0.3	0.3	1.1	1.1	-0.4	0.3	0.1
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.0	-0.2	-0.1	0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	0.3	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.6	0.6	1.2	-0.6	-1.1	0.8	0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.7	-0.8	-0.1	0.1	-0.4
Indifference point function ln k	0.1	0.1	0.2	-0.5	-0.1	0.4	0.2
Indifference point function log k	0.1	0.1	0.2	-0.5	-0.1	0.4	0.2
Patch foraging total patch changes 0 sec	0.4	0.7	2.0	-0.7	1.4	-0.4	-0.4
Patch foraging total patch changes 12 sec	0.4	0.6	2.3	1.5	-0.2	-0.1	0.2
Patch foraging total patch changes 18 sec	0.2	0.4	1.3	0.2	1.1	-0.3	-0.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.3	0.4	0.6	-0.0	-0.0
Patch foraging total patch changes 6 sec	0.2	0.3	0.6	-0.2	-0.2	0.6	0.8
Patch foraging time to switch 0 sec	0.3	0.5	1.8	-1.3	0.1	0.1	-0.6
Patch foraging water rate 0 sec	0.1	0.2	0.5	0.4	-0.1	0.3	0.7
Patch foraging water rate 12 sec	0.3	0.7	1.2	0.3	-1.1	1.0	0.8
Patch foraging water rate 18 sec	0.1	0.2	0.4	0.6	-0.1	0.5	0.3
Patch foraging water rate 24 sec	0.6	0.8	3.1	1.8	0.1	0.2	0.1
Patch foraging water rate 6 sec	0.7	1.0	1.9	0.2	-1.4	1.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2
Distance traveled before self-admin	2.5	3.3	6.9	2.6	-1.4	1.2	1.7
Distance traveled after self-admin	1.0	1.2	3.7	1.9	-0.0	0.4	0.9
Extensor digitorum longus weight	0.1	0.3	0.5	0.7	-0.3	0.4	0.7
Bone: elastic displacement	1.0	1.2	2.4	0.7	-1.5	1.3	0.4
Bone: elastic work	2.2	2.9	4.5	1.0	-2.1	2.1	1.3
Bone: endosteal estimation	1.6	3.5	4.0	-1.9	1.5	-2.0	-2.0
Bone: endosteal perimeter	0.4	0.8	1.2	-1.0	0.5	-1.1	-0.9
Epididymis fat weight	0.1	0.2	0.5	0.2	0.7	-0.6	0.0
Delta time in closed arm before/after self-admin	1.1	1.0	2.0	0.1	1.4	-1.0	-1.0
Delta time in open arm before/after self-admin	1.5	1.5	2.4	-1.6	-1.3	1.0	1.0
Diff in mean of infusions in LGA sessions	0.9	1.1	4.1	2.0	0.4	-0.1	-0.2
Delay discount exponential model param	0.0	0.0	0.1	0.2	0.2	-0.1	0.2
Extinction: sum of active levers before priming	1.3	1.4	3.2	1.8	-1.1	0.7	0.8
Active lever presses in extinction session 6	2.3	2.3	8.6	2.9	-0.5	0.5	0.2
Bone: final force	0.2	0.3	0.6	-0.3	-0.7	0.8	0.3
Bone: final moment	0.5	0.8	1.4	-0.1	-1.1	1.2	0.8
Food consumed during 24 hour testing period	0.0	0.0	0.2	0.4	-0.1	-0.1	0.0
Glucose	2.0	3.1	4.9	1.1	-1.4	2.2	2.0
Heart weight	1.9	3.0	4.4	-0.4	2.1	-1.8	-2.0
Delay discount hyperbolic model param	0.1	0.1	0.1	0.2	0.4	-0.2	0.1
Intermittent access intake day 1-15 change	0.4	0.8	1.2	0.9	-1.1	0.6	0.9
Intermittent access intake escalation	0.7	1.4	1.9	1.3	-1.4	0.8	1.1
Intermittent access intake escalation 2	0.4	0.5	0.8	0.9	-0.6	0.5	0.8
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.2	1.1	1.0	-0.7	-0.7
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.2	0.3	-0.5	0.5	0.4
Intermitt. access escalation Index	0.5	0.7	1.1	0.4	0.9	-1.0	-0.9
Intermittent access day 1 total infusions	0.7	1.1	2.5	1.6	-1.1	0.8	0.5
Intermittent access day 15 total infusions	1.0	1.5	3.2	1.8	-1.3	0.6	0.7
Intermittent access terminal intake (last 3 days)	0.8	1.0	1.8	1.3	-1.1	0.8	0.7
Intermittent access total infusions	0.4	0.4	1.5	0.3	-1.2	0.3	0.2
Intermittent access day 1 locomotion	0.3	0.4	1.0	1.0	-0.3	0.6	0.3
Intermittent access day 15 total locomotion	0.1	0.2	0.4	-0.0	-0.7	0.4	0.0
Intermittent access total locomotion	0.1	0.1	0.2	0.2	-0.5	0.4	0.0
Intermittent access standard deviation	0.2	0.3	1.4	-0.1	-1.2	-0.1	0.0
Left kidney weight	0.2	0.9	2.5	1.6	-0.2	0.4	0.8
Right kidney weight	0.2	1.1	1.4	1.1	1.1	-1.2	-0.7
Cocaine induced anxiety	0.4	0.6	2.1	1.4	-0.1	0.1	0.4
Post-drug Anxiety	0.1	0.1	0.3	0.6	0.2	0.0	-0.0
Baseline Anxiety	1.2	1.3	4.5	-2.1	0.6	-0.2	-0.7
Tail length	0.6	2.5	2.7	1.6	-1.5	1.7	1.6
Length with tail	0.4	1.6	4.7	2.2	-0.6	0.8	0.8
Length without tail	0.2	0.8	2.1	1.4	0.8	-0.4	-0.2
LgA early post infusion interval	0.4	0.5	0.7	0.5	-0.8	0.7	0.9
LgA late post infusion interval	0.8	1.0	1.8	1.3	-0.4	1.0	0.9
LgA early loading	1.5	2.8	5.9	-2.4	1.5	-1.0	-1.4
LgA late loading	2.0	4.6	15.4	-3.9	0.4	-1.1	-1.3
LgA early average infusions	6.7	8.3	16.8	-4.1	2.2	-2.1	-2.7
LgA late average infusions	4.4	6.2	19.7	-4.4	0.8	-1.4	-1.6
LgA early timeout	1.6	1.7	3.8	-1.9	0.7	-1.0	-1.2
LgA late timeout	0.5	0.6	2.3	-1.5	-0.0	-0.3	-0.4
LgA early titration	4.8	6.7	16.3	-4.0	2.1	-1.5	-2.0
LgA late titration	3.4	5.1	11.6	-3.4	1.4	-1.7	-1.9
LgA total infusion	10.0	13.9	29.8	-5.5	2.8	-2.9	-3.1
Times rat made contact with spout	2.4	2.8	3.7	1.1	-1.8	1.9	1.7
Lifetime Intake	0.5	0.7	2.2	0.4	-1.5	0.5	0.3
Liver weight, left	0.8	1.3	1.7	0.6	-1.3	1.2	1.3
Liver weight, right	0.8	1.4	2.9	0.9	-0.9	1.1	1.7
Locomotor activity	0.5	0.7	2.6	-1.6	0.2	-0.3	-0.4
Locomotor testing distance	0.5	0.9	1.5	-1.2	-0.7	1.0	0.9
Locomotor testing rearing	0.7	1.4	3.4	0.5	-0.6	1.3	1.8
Locomotion in novel chamber	1.5	1.9	3.4	0.7	-1.4	1.8	1.3
Locomotion in novel chamber post-restriction	0.2	0.4	0.6	0.0	-0.6	0.8	0.8
Fecal boli incidents, locomotor time 1	1.5	2.2	3.8	0.6	1.2	-1.8	-1.9
Change in fecal boli incidents, locomotor task	1.1	1.1	2.6	-1.6	-0.5	0.9	0.8
Time >=10cm from walls, locomotor time 1	1.7	1.8	4.1	2.0	-0.9	1.2	0.9
Bouts of movement, locomotor time 1	0.5	0.6	1.0	-0.1	0.6	-0.9	-1.0
Total resting periods, locomotor time 1	0.6	0.7	1.1	0.3	0.8	-0.9	-1.1
Rest time, locomotor task time 1	0.3	0.4	0.7	-0.7	-0.0	-0.6	-0.9
Distance moved, locomotor task time 1	0.3	0.5	1.8	-1.3	0.2	-0.0	0.1
Vertical activity count, locomotor time 1	0.8	1.8	3.9	-2.0	1.4	-0.9	-0.9
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.1	1.1	1.0	-0.5	-0.6
Bouts of movement, locomotor time 2	0.7	1.2	3.9	-2.0	-0.7	0.6	0.1
Total resting periods, locomotor time 2	1.1	1.9	5.2	-2.3	-1.1	1.0	0.5
Rest time, locomotor task time 2	1.4	1.8	5.2	-0.7	-2.3	1.0	0.6
Distance moved, locomotor task time 2	2.0	2.3	5.2	-0.6	2.3	-1.6	-1.1
Vertical activity count, locomotor time 2	2.2	3.1	6.9	-0.8	2.6	-1.7	-1.4
Light reinforcement 1	3.2	7.9	18.6	4.3	-2.0	2.2	1.9
Light reinforcement 2	0.9	1.4	5.3	2.3	-0.6	0.1	-0.2
Bone: marrow area	1.6	3.5	4.1	-1.9	1.6	-2.0	-2.0
Bone: maximum diameter	0.0	0.1	0.2	-0.2	-0.5	0.0	0.1
Bone: maximum force	0.3	0.6	1.8	-1.3	0.4	-0.3	-0.6
Bone: maximum moment	0.2	0.3	1.2	-1.1	-0.1	0.2	-0.1
Mean time between licks in bursts	0.3	0.8	1.4	-0.1	0.8	-1.2	-1.1
Mean num. licks in bursts	3.8	6.0	8.5	1.0	-2.9	2.8	2.6
Cd content in liver	0.1	0.1	0.2	-0.4	0.1	-0.4	-0.5
Co content in liver	0.3	0.4	1.3	-1.1	-0.2	-0.0	-0.4
Cu content in liver	1.8	2.2	3.4	0.9	-1.4	1.8	1.6
Fe content in liver	2.7	3.3	3.9	-1.7	2.0	-2.0	-1.7
K content in liver	0.8	0.8	2.0	-1.4	0.6	-0.8	-0.3
Mg content in liver	0.6	0.6	0.9	-0.9	0.6	-0.9	-0.6
Mn content in liver	1.4	1.6	1.9	-1.2	1.1	-1.3	-1.4
Na content in liver	1.7	1.9	2.3	-1.5	1.5	-1.2	-1.3
Rb content in liver	0.1	0.2	0.4	-0.2	-0.4	-0.2	-0.6
Se content in liver	1.1	1.3	1.6	-0.9	1.1	-1.3	-1.2
Sr content in liver	0.9	0.8	1.1	-0.0	-1.0	1.1	0.9
Zn content in liver	0.0	0.0	0.1	0.2	0.0	0.1	0.0
Bone: minimum diameter	0.1	0.3	0.7	-0.8	-0.0	-0.2	-0.5
Time in familiar zone, hab. session 1	1.0	1.0	3.1	1.8	-0.7	0.5	0.3
Time in novel zone, hab. session 1	0.5	0.5	1.3	-1.1	0.8	-0.4	-0.1
Total zone transitions, hab. session 1	1.8	2.5	4.4	-1.1	-0.7	2.0	2.1
Total locomotion distance, hab. session 1	1.0	1.4	2.3	-1.0	-0.7	1.4	1.5
Locomotion velocity, hab. session 1	0.9	1.2	1.9	-0.9	-0.7	1.3	1.4
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.1
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.3	0.0	-0.0	-0.3
Total zone transitions, hab. session 2	0.5	0.6	0.9	-1.0	-0.2	0.8	0.9
Total locomotion distance, hab. session 2	0.7	0.9	1.2	-0.8	-0.9	1.1	1.0
Locomotion velocity, hab. session 2	0.7	0.9	1.3	-0.6	-0.9	1.2	1.1
Novel to familiar place preference ratio	0.1	0.2	0.3	0.5	-0.6	0.3	0.1
Novelty place preference	0.1	0.2	0.4	0.4	-0.6	0.2	0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.2	-0.4	0.2	0.1
Total zone transitions, NPP test	1.3	1.9	3.4	0.1	-1.0	1.8	1.8
Total locomotion distance, NPP test	1.3	1.8	3.2	0.1	-1.3	1.8	1.5
Locomotion velocity, NPP test	1.2	1.7	2.9	0.3	-1.3	1.7	1.5
Intraocular pressure	0.5	0.7	2.4	1.5	-0.7	0.2	-0.2
Delta distance traveled before/after self-admin	0.5	0.5	1.1	-0.7	1.1	-0.4	-0.5
Delta ambulatory time before/after self-admin	0.4	0.5	1.0	-0.3	1.0	-0.6	-0.7
Parametrial fat weight	0.6	1.4	2.4	-0.1	1.5	-1.2	-1.4
Pavlov. Cond. lever latency	0.3	0.3	0.5	-0.7	0.5	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.3	0.3	0.7	-0.0	-0.7	0.4	0.8
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.7	0.0	0.3	0.5
Pavlov. Cond. index score	0.5	0.6	1.0	0.4	-0.8	0.7	1.0
Pavlov. Cond. latency score	0.6	0.8	1.3	0.6	-0.9	0.8	1.1
Pavlov. Cond. lever contacts	0.4	0.4	0.7	0.8	-0.4	0.6	0.8
Pavlov. Cond. magazine entry number	0.7	0.8	2.0	-0.1	0.7	-0.9	-1.4
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.6	-0.9	0.6	-1.3	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	0.5	-0.8	0.7	0.9
Pavlov. Cond. response bias	0.1	0.2	0.5	0.1	-0.2	0.4	0.7
Pavlov. Cond. lever latency	0.8	1.1	2.1	-1.5	1.0	-0.7	-0.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.7	0.3	-0.3	-0.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.9	0.9	-0.3	0.1	0.3
Pavlov. Cond. index score	0.4	0.6	1.7	1.3	-0.5	0.3	0.5
Pavlov. Cond. latency score	0.4	0.5	1.5	1.2	-0.4	0.3	0.5
Pavlov. Cond. lever contacts	0.7	0.9	1.7	1.3	-0.7	0.7	0.9
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	-1.1	0.7	-0.6	-0.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.0	-0.5	-0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.9	1.4	-0.5	0.4	0.6
Pavlov. Cond. response bias	0.9	1.2	2.1	1.4	-1.0	0.8	1.1
LgA PC1 addiction-like behavior	7.1	13.8	32.6	-5.7	2.6	-2.6	-3.0
Time in closed arm before self-admin	1.3	1.7	3.7	0.7	-1.9	1.0	1.2
Time in closed arm after self-admin	0.7	0.8	2.2	0.8	-1.5	0.4	0.2
Time in open arm before self-admin	1.3	1.4	2.5	1.3	1.6	-0.8	-1.0
Time in open arm after self-admin	0.7	0.8	2.7	-1.7	0.7	-0.0	0.2
Bone: periosteal estimation	0.1	0.3	0.7	-0.9	0.0	-0.3	-0.5
Bone: periosteal perimeter	0.2	0.3	0.5	-0.6	0.4	-0.7	-0.5
Bone: post-yield work	2.6	3.8	5.3	-1.7	1.7	-2.3	-2.0
Progressive ratio test 1 active lever presses	1.0	1.3	2.6	0.4	-1.6	1.1	1.1
Progressive ratio test 1 breakpoint	1.1	1.3	2.6	0.4	-1.6	1.1	1.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.5	-0.1	-0.7	0.1	0.1
Progressive ratio test 2 active lever presses	0.3	0.4	1.0	0.4	-1.0	0.3	0.4
Progressive ratio test 2 breakpoint	0.4	0.4	1.1	0.5	-1.0	0.4	0.5
Progressive ratio test 2 inactive lever presses	0.6	1.0	1.9	1.1	-1.4	0.6	0.6
ShA PR total presses	9.9	11.4	21.8	-4.7	3.0	-2.7	-2.7
Incentive Sensitization - Responses	0.1	0.1	0.3	-0.1	0.0	-0.6	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.0	0.2	-0.7	-0.5
LgA PR total presses	1.5	1.6	3.7	-1.9	0.9	-1.0	-0.8
Sum of active levers in priming session hrs 5-6	3.7	3.4	10.9	3.3	-0.9	1.2	0.8
Progressive ratio	0.5	0.7	1.1	0.7	-1.1	0.8	0.8
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.3	-0.3	-0.2	0.2
Seeking ratio, punishment vs. effort	0.5	0.7	0.9	-0.7	0.7	-1.0	-0.9
Retroperitoneal fat weight	0.2	0.9	2.6	1.6	0.1	0.6	0.7
Reaction time number correct	5.0	9.6	14.1	1.3	-3.4	3.8	3.3
Reaction time mean minus median	0.8	1.9	3.1	-0.7	1.2	-1.8	-1.6
Reaction time mean minus median AUC	0.3	0.8	1.7	-0.4	0.5	-1.3	-1.0
Reaction time num false alarms	0.6	0.9	2.0	-0.4	1.4	-1.0	-0.7
Reaction time num false alarms AUC	0.2	0.3	0.9	-0.0	0.9	-0.5	-0.4
Reaction time trials correct on left	5.0	9.6	14.1	1.3	-3.4	3.8	3.3
Reaction time trials on left	5.3	10.0	14.7	1.3	-3.5	3.8	3.4
Reaction time mean	5.7	9.0	14.4	-1.3	2.8	-3.8	-3.5
Reaction time mean AUC	4.6	7.4	11.4	-1.5	2.4	-3.4	-3.2
Median of all reaction times	8.0	11.4	17.5	-1.7	3.2	-4.2	-3.9
Reaction time omissions	0.1	0.1	0.5	0.7	-0.3	-0.1	0.1
Reaction time false alarm rate	3.5	4.8	7.6	-0.7	2.8	-2.5	-2.2
Reaction time premature initiation rate	0.1	0.1	0.2	-0.4	0.4	-0.0	-0.4
Reaction time premature initiations	1.0	1.9	3.4	0.2	-1.5	1.8	1.3
Std. dev. reaction times	1.0	1.8	3.0	-0.6	1.1	-1.7	-1.6
Reaction time trials completed	5.3	10.0	14.7	1.3	-3.5	3.8	3.4
Reaction time trials AUC	5.3	10.1	14.7	1.3	-3.5	3.8	3.4
Run reversals in cocaine runway, females	0.4	0.4	1.3	0.5	-1.2	0.0	-0.1
Run reversals in cocaine runway, males	0.3	0.3	0.9	0.3	-0.3	-0.3	-0.9
Latency to leave start box in cocaine runway	0.6	0.7	2.0	-0.7	-1.4	0.4	0.2
Latency to leave start box in cocaine runway, F	0.4	0.4	0.7	-0.7	-0.0	-0.7	-0.8
Latency to leave start box in cocaine runway, M	2.3	2.2	4.9	-0.0	-2.2	1.4	1.4
Std. dev. time between licks in bursts	0.6	0.8	1.7	0.1	1.3	-1.1	-0.5
Total sessions with >9 infusions	0.8	0.9	2.2	0.6	-1.5	1.0	0.5
Short access day 1 total inactive lever presses	0.9	1.2	1.4	1.1	-1.2	1.2	0.8
Short access day 10 total inactive lever presses	0.4	1.1	2.9	1.7	0.9	-0.5	-0.5
Short access day 1 total infusions	2.3	3.1	5.7	1.1	-2.4	2.0	1.3
Short access day 10 total infusions	0.7	0.9	2.1	0.8	-1.4	0.9	0.5
Short access total infusions	1.1	1.4	3.6	0.8	-1.9	1.0	0.6
ShA early post infusion interval	1.2	1.1	1.7	-0.6	-1.3	0.9	1.3
ShA late post infusion interval	0.6	0.6	1.6	1.3	0.1	0.5	0.8
ShA early loading	0.2	0.2	0.7	-0.8	-0.3	0.2	0.0
ShA late loading	6.2	8.3	11.6	-3.4	2.6	-2.6	-2.8
Short access day 1 locomotion	1.0	1.2	1.8	0.9	-0.9	1.3	1.2
Short access day 10 total locomotion	0.1	0.1	0.2	-0.4	0.5	-0.1	0.1
Short access total locomotion	0.1	0.1	0.3	-0.0	-0.3	0.5	0.2
ShA early average infusions	2.0	2.4	3.1	-1.2	1.8	-1.6	-1.5
ShA late average infusions	8.3	8.6	12.9	-3.6	2.6	-2.6	-2.8
ShA early timeout	1.0	1.1	1.4	-1.1	1.2	-0.9	-1.0
ShA late timeout	6.5	7.0	9.3	-1.9	3.1	-2.7	-2.7
ShA early titration	0.5	0.5	1.3	0.3	1.1	-0.7	-0.5
ShA late titration	5.2	5.5	7.5	-2.7	2.2	-2.2	-2.2
ShA total infusions	6.1	7.5	10.7	-3.3	2.6	-2.4	-2.5
One hour access (0.3 mA shock)	0.4	0.4	1.0	-0.4	-1.0	-0.0	0.7
Shock compulsivity	0.2	0.3	1.1	0.3	1.1	0.1	0.4
Compulsive drug intake	1.1	1.3	2.4	-0.3	1.3	-1.5	-1.0
One hour access (shock baseline)	1.2	1.9	3.6	-0.2	-1.9	1.4	1.4
Social response proportion	2.7	3.0	4.3	1.5	-1.7	1.7	2.1
Social responses	1.1	1.4	2.4	1.5	0.2	1.2	1.4
Social time	0.6	0.9	2.8	1.7	0.8	-0.1	-0.3
Soleus weight	0.0	0.0	0.0	0.0	0.2	-0.2	0.2
Bone: stiffness	0.3	0.5	1.6	-1.3	0.5	-0.3	-0.1
Tibialis anterior weight	0.3	0.9	1.3	0.5	-1.1	0.9	1.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	-0.8	-0.6	0.4	-0.2
Time to tail flick, vehicle, after self-admin	1.6	2.2	7.5	2.7	0.8	0.5	0.5
Time to tail flick, test, before self-admin	0.9	0.9	3.0	-1.7	0.9	-0.2	-0.2
Time to tail flick, test, after self-admin	0.4	0.4	1.3	0.4	1.1	-0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	4.1	2.0	0.6	0.3	0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.2	0.6	-0.3	-0.0
Tibia length	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1
Ambulatory time before self-admin	3.0	4.5	7.2	2.7	-1.8	1.6	2.3
Ambulatory time after self-admin	1.5	1.7	4.6	2.1	-0.4	0.6	1.3
Bone: tissue strength	0.1	0.1	0.3	-0.0	-0.2	-0.1	0.5
Total heroin consumption	2.4	2.9	7.9	2.8	-1.1	1.3	0.9
Total infusions	10.0	13.0	26.7	-5.2	2.8	-2.8	-3.1
Bone: trabecular number	0.1	0.1	0.4	-0.2	0.6	-0.2	0.1
Bone: trabecular spacing	0.5	0.7	1.8	0.3	-1.4	0.6	0.6
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	0.4	-0.3	-0.1
Bone: trabecular tissue density	0.0	0.0	0.1	-0.1	0.3	0.3	0.0
Water consumed over 24 hours	0.4	0.6	1.1	0.3	-0.8	1.1	0.8
Number of responses in last shaping day	1.3	1.5	5.6	-2.4	-0.5	0.1	0.1