Hub : Genes

Clrn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Clrn1	0.12	0.11	5.2e-04	0.05	0.05	0.06	0.05	1.0e-03	9.7e-04	4.0e-04	1.2e-03
2	Brain	gene expression	Clrn1	0.3	0.21	0.0e+00	0.22	0.22	0.23	0.22	1.0e-20	8.2e-20	7.5e-21	1.4e-20
3	PL	gene expression	Clrn1	0.08	0.07	3.2e-08	0.06	0.05	0.04	0.05	9.8e-07	3.3e-06	1.1e-05	4.7e-06
4	pVTA	gene expression	Clrn1	0.4	0.19	0.0e+00	0.35	0.39	0.39	0.38	9.2e-29	2.9e-33	1.7e-33	1.2e-32
5	Eye	gene expression	Clrn1	0.45	0.32	3.8e-04	0.15	0.21	0.14	0.22	3.0e-03	3.9e-04	3.6e-03	2.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.7	1.3	1.8	-0.2	1.1	1.3	1.3	-1.3
Area under the delay curve	3.0	4.7	9.6	-3.1	-2.1	-1.6	-2.1	1.6
BMI with tail	1.9	6.6	10.8	-3.3	-2.4	-2.3	-2.5	2.2
BMI without tail	1.4	7.3	16.2	-4.0	-2.4	-2.1	-2.5	2.0
Body weight	1.5	6.7	7.7	-2.1	-2.6	-2.7	-2.8	2.7
Weight adjusted by age	0.7	2.2	8.1	-2.8	0.4	1.0	0.3	-1.2
Bone surface	0.4	0.7	3.5	-1.9	-0.3	0.0	-0.1	-0.0
Bone volume	0.5	0.9	1.3	-0.4	0.9	1.1	1.1	-1.1
Breakpoint value in progressive ratio session	0.4	0.7	3.3	-1.8	-0.3	0.1	-0.1	0.0
Number of licking bursts	0.2	0.6	3.2	-1.8	-0.0	0.0	-0.0	-0.0
Context. condit. distance diff. score	0.6	0.8	1.1	-0.3	1.0	1.0	0.9	-1.0
Locomotion velocity, session 1	0.3	0.3	0.6	0.8	0.4	0.5	0.5	-0.5
Locomotion distance, session 1	0.8	1.0	4.8	2.2	0.3	-0.3	0.4	0.2
Locomotion velocity, session 2	4.1	4.9	5.8	2.1	2.3	2.1	2.4	-2.1
Locomotion distance, session 2	1.0	1.4	6.7	2.6	0.4	0.1	0.5	-0.1
Locomotion velocity, session 3	0.1	0.1	0.1	-0.4	-0.3	-0.2	-0.3	0.2
Locomotion distance, session 3	0.4	0.4	1.9	-1.4	-0.3	-0.0	-0.4	0.1
Stereotopy head waving bouts, day 3	0.8	1.0	1.5	1.2	1.0	0.8	1.0	-0.8
Stereotopy head waving duration, day 3	0.9	1.1	1.9	1.4	1.0	0.9	1.0	-0.9
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	0.3	0.4	0.3	-0.4
Locomotion distance, session 7	0.1	0.1	0.1	0.3	0.4	0.3	0.3	-0.3
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	-0.1	0.6	0.9	0.7	-0.9
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.3	0.2	0.6	0.4	-0.6
Locomotion velocity, session 8	1.3	1.5	6.8	2.6	-0.1	-0.7	-0.2	0.6
Locomotion distance, session 8	0.4	0.5	2.1	1.5	0.5	0.2	0.5	-0.2
Degree of sensitization distance	0.3	0.3	1.1	1.1	0.3	0.1	0.4	-0.1
Degree of sensitization stereotypy	0.3	0.4	0.6	0.1	0.5	0.8	0.6	-0.8
Conditioned locomotion	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.4	0.3
Cocaine response after cond. corrected	1.4	2.1	3.7	-1.9	-1.3	-1.3	-1.4	1.3
Cocaine response after cond. not corrected	2.1	3.0	7.0	-2.6	-1.5	-1.3	-1.5	1.3
Cocaine response before conditioning	0.4	0.5	0.7	-0.8	0.4	0.8	0.4	-0.8
Saline control response	0.6	0.9	1.2	-0.7	-1.1	-0.9	-1.1	0.9
Bone: connectivity density	0.1	0.1	0.4	-0.6	-0.2	-0.2	-0.1	0.2
Bone: cortical apparent density	3.1	4.9	6.7	0.1	2.4	2.6	2.4	-2.6
Bone: cortical area	0.1	0.2	0.5	-0.7	0.0	0.4	0.0	-0.4
Bone: cortical porosity	0.3	0.3	0.9	1.0	-0.2	-0.5	-0.2	0.5
Bone: cortical porosity	0.4	0.4	0.5	-0.3	-0.6	-0.7	-0.7	0.7
Bone: cortical thickness	1.0	1.6	2.1	1.0	1.2	1.5	1.2	-1.5
Bone: cortical thickness	0.2	0.2	0.9	1.0	-0.1	-0.1	-0.2	0.1
Bone: cortical tissue density	2.7	4.3	5.8	-0.1	2.2	2.4	2.2	-2.4
Condit. Reinf. active minus inactive responses	5.3	6.0	8.9	-0.7	-2.4	-2.9	-2.5	3.0
Condit. Reinf. active-inactive response ratio	4.9	5.2	8.3	0.0	-2.2	-2.8	-2.2	2.9
Condit. Reinf. active responses	7.1	9.2	12.5	-1.1	-3.1	-3.5	-3.1	3.5
Condit. Reinf. inactive responses	1.8	2.3	2.9	-1.0	-1.7	-1.6	-1.7	1.6
Incentive salience index mean	2.4	3.1	4.7	-0.5	-1.7	-2.1	-1.8	2.2
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.1	-0.0	-0.3	-0.2	0.3
Condit. Reinf. active minus inactive responses	1.6	2.4	3.5	-1.9	-1.6	-1.4	-1.5	1.4
Condit. Reinf. active-inactive response ratio	2.7	4.3	12.0	-3.5	-1.8	-1.4	-1.6	1.4
Condit. Reinf. active responses	0.2	0.3	0.5	-0.1	-0.7	-0.5	-0.6	0.5
Condit. Reinf. inactive responses	1.1	1.7	6.6	2.6	0.8	0.6	0.7	-0.6
Condit. Reinf. lever presses	2.2	3.2	4.2	0.1	-2.0	-2.0	-1.9	2.0
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	0.1	-0.6	-0.4	-0.6	0.4
Conditioned reinforcement - actives	0.5	2.0	5.5	2.3	1.3	0.7	1.2	-0.9
Conditioned reinforcement - inactives	0.2	0.5	0.9	1.0	-0.3	-0.7	-0.4	0.8
Conditioned locomotion	0.5	0.8	1.6	1.3	1.0	0.5	0.9	-0.6
Patch foraging indifference point 0 sec	0.1	0.3	0.8	-0.5	0.2	0.9	0.3	-0.7
Patch foraging indifference point AUC	0.8	1.9	9.4	3.1	0.2	-0.2	0.3	0.3
Delay disc. indifference point, 0s delay	1.5	1.7	1.9	-1.3	-1.4	-1.2	-1.4	1.2
Delay disc. indifference point, 16s delay	4.2	6.0	6.5	-2.5	-2.5	-2.4	-2.6	2.3
Delay disc. indifference point, 2s delay	1.0	1.1	1.4	-1.2	-1.0	-1.1	-1.0	1.0
Delay disc. indifference point, 24s delay	1.3	2.0	3.3	-1.8	-1.4	-1.2	-1.4	1.2
Delay disc. indifference point, 4s delay	1.4	1.4	4.2	-2.0	-1.0	-0.7	-0.9	0.7
Delay disc. indifference point, 8s delay	1.2	2.0	4.7	-2.2	-1.4	-0.9	-1.4	0.9
Indifference point function ln k	1.5	4.7	19.6	-4.4	-1.2	-0.7	-1.2	0.7
Indifference point function log k	1.5	4.7	19.6	-4.4	-1.2	-0.7	-1.2	0.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.5	-0.1	0.5	0.0	-0.4
Patch foraging total patch changes 12 sec	1.5	2.0	5.0	2.2	1.2	1.1	1.2	-1.1
Patch foraging total patch changes 18 sec	0.8	1.8	7.8	2.8	0.5	0.5	0.7	-0.4
Patch foraging total patch changes 24 sec	0.2	0.7	1.3	1.1	0.6	0.9	0.7	-0.8
Patch foraging total patch changes 6 sec	0.2	0.3	0.7	0.4	-0.1	0.9	0.3	-0.7
Patch foraging time to switch 0 sec	0.4	1.4	2.2	0.3	1.2	1.4	1.2	-1.5
Patch foraging water rate 0 sec	0.3	1.0	1.2	-0.9	-1.1	-1.0	-1.1	1.0
Patch foraging water rate 12 sec	0.3	1.4	2.6	-1.6	0.9	1.1	0.7	-1.3
Patch foraging water rate 18 sec	0.6	1.4	6.7	-2.6	-0.3	-0.0	-0.4	0.1
Patch foraging water rate 24 sec	0.3	0.5	0.7	-0.1	0.8	0.8	0.7	-0.8
Patch foraging water rate 6 sec	0.5	0.8	2.9	-1.7	-0.6	-0.2	-0.7	0.1
Seeking ratio, delayed vs. immediate footshock	1.0	1.5	2.8	-0.4	0.7	1.7	1.2	-1.6
Distance traveled before self-admin	0.9	2.0	9.5	3.1	0.1	-0.4	0.2	0.5
Distance traveled after self-admin	0.4	0.7	2.2	1.5	-0.3	-0.7	-0.3	0.8
Extensor digitorum longus weight	1.7	6.9	7.3	-2.5	-2.7	-2.6	-2.7	2.6
Bone: elastic displacement	1.2	1.6	7.5	2.7	0.4	0.1	0.3	-0.1
Bone: elastic work	1.8	2.3	9.5	3.1	0.8	0.6	0.8	-0.6
Bone: endosteal estimation	1.4	3.4	7.7	-2.8	-1.7	-1.4	-1.6	1.4
Bone: endosteal perimeter	0.6	1.4	1.8	-1.4	-1.1	-1.2	-1.0	1.2
Epididymis fat weight	0.2	1.0	1.3	0.7	-1.0	-1.1	-0.9	1.1
Delta time in closed arm before/after self-admin	0.4	0.3	1.0	1.0	0.6	0.3	0.4	-0.3
Delta time in open arm before/after self-admin	1.2	1.4	6.4	2.5	0.5	0.2	0.7	-0.1
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.1	0.5
Delay discount exponential model param	2.9	3.9	8.3	2.9	1.9	1.5	1.9	-1.5
Extinction: sum of active levers before priming	0.7	1.1	1.7	-1.3	-1.0	-0.9	-1.0	0.9
Active lever presses in extinction session 6	0.4	0.4	0.8	-0.9	-0.8	-0.1	-0.7	0.3
Bone: final force	0.2	0.3	0.6	-0.8	0.3	0.7	0.3	-0.7
Bone: final moment	0.2	0.3	0.6	-0.8	0.3	0.7	0.3	-0.7
Food consumed during 24 hour testing period	1.0	2.0	6.6	-2.6	-1.2	-0.6	-1.2	0.6
Glucose	2.6	4.1	5.8	-0.8	-2.0	-2.4	-2.1	2.4
Heart weight	0.0	0.1	0.3	0.5	-0.1	-0.0	-0.1	-0.0
Delay discount hyperbolic model param	3.3	4.2	8.8	3.0	1.9	1.6	1.9	-1.6
Intermittent access intake day 1-15 change	0.2	1.0	4.4	2.1	0.5	0.3	0.5	0.1
Intermittent access intake escalation	0.2	1.1	5.0	2.2	0.5	0.3	0.5	0.1
Intermittent access intake escalation 2	0.5	0.9	4.2	2.1	0.0	-0.2	0.0	0.5
Intermitt. access day 1 inactive lever presses	0.1	1.6	2.0	-1.0	-1.1	-1.4	-1.2	1.4
Intermitt. access day 15 inactive lever presses	0.2	1.0	3.1	1.8	-0.1	-0.9	-0.2	1.0
Intermitt. access escalation Index	1.2	3.7	16.8	4.1	0.8	0.5	0.9	-0.2
Intermittent access day 1 total infusions	0.1	0.4	1.5	1.2	0.4	-0.1	0.3	0.0
Intermittent access day 15 total infusions	0.6	1.5	6.7	2.6	0.5	-0.1	0.5	0.3
Intermittent access terminal intake (last 3 days)	0.8	1.4	6.2	2.5	0.3	-0.3	0.2	0.6
Intermittent access total infusions	1.6	1.9	8.5	2.9	0.8	0.2	0.8	-0.0
Intermittent access day 1 locomotion	0.2	0.3	0.9	0.9	-0.1	-0.6	-0.0	0.5
Intermittent access day 15 total locomotion	0.2	0.7	1.3	-0.1	-0.8	-1.0	-0.8	1.1
Intermittent access total locomotion	0.2	0.2	0.5	0.7	-0.1	-0.6	-0.0	0.5
Intermittent access standard deviation	0.1	0.4	0.6	-0.6	0.8	0.4	0.8	-0.4
Left kidney weight	0.0	0.2	0.5	0.7	0.1	0.4	0.1	-0.5
Right kidney weight	0.2	1.7	5.8	2.4	0.7	0.9	0.6	-0.9
Cocaine induced anxiety	0.2	0.5	1.4	1.2	-0.3	-0.8	-0.2	0.6
Post-drug Anxiety	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2	-0.0
Baseline Anxiety	0.5	0.9	1.4	-0.7	0.9	1.2	0.9	-1.1
Tail length	0.1	0.6	1.0	-0.6	-1.0	-0.6	-1.0	0.7
Length with tail	0.3	1.1	1.6	-0.1	-1.1	-1.2	-1.2	1.3
Length without tail	0.2	1.3	2.2	0.1	-0.9	-1.5	-1.1	1.5
Times rat made contact with spout	0.1	0.1	0.1	0.2	0.3	0.3	0.4	-0.3
Lifetime Intake	1.8	2.3	8.8	3.0	1.1	0.5	1.0	-0.4
Liver weight, left	0.1	0.1	0.2	-0.4	0.3	0.3	0.4	-0.5
Liver weight, right	1.5	2.7	5.3	2.3	1.6	1.3	1.5	-1.3
Locomotor activity	1.2	1.8	2.4	-0.4	-1.5	-1.5	-1.5	1.5
Locomotor testing distance	2.9	7.0	9.0	-0.6	-3.0	-3.0	-2.8	3.0
Locomotor testing rearing	0.3	1.0	1.1	1.0	-0.9	-1.0	-0.9	1.1
Locomotion in novel chamber	2.4	3.2	13.9	3.7	1.0	0.3	1.0	-0.3
Locomotion in novel chamber post-restriction	0.2	0.6	0.7	0.7	0.8	0.9	0.8	-0.9
Fecal boli incidents, locomotor time 1	0.9	2.5	6.6	2.6	-0.7	-1.5	-0.8	1.5
Change in fecal boli incidents, locomotor task	1.0	1.1	3.2	-1.8	0.4	0.9	0.4	-1.0
Time >=10cm from walls, locomotor time 1	0.7	0.9	1.4	-1.2	0.8	1.0	0.6	-1.0
Bouts of movement, locomotor time 1	1.6	2.0	3.8	2.0	1.2	1.4	1.0	-1.4
Total resting periods, locomotor time 1	2.8	3.2	3.8	1.9	1.7	1.9	1.5	-1.9
Rest time, locomotor task time 1	1.7	2.8	3.9	0.5	1.8	2.0	1.7	-2.0
Distance moved, locomotor task time 1	0.4	1.2	1.7	-0.5	-1.0	-1.3	-1.1	1.3
Vertical activity count, locomotor time 1	0.1	0.4	0.6	-0.1	-0.6	-0.8	-0.6	0.7
Time >=10cm from walls, locomotor time 2	0.6	1.7	2.3	1.5	1.3	1.3	1.3	-1.2
Bouts of movement, locomotor time 2	0.8	2.7	4.9	0.1	1.4	2.2	1.4	-2.2
Total resting periods, locomotor time 2	0.6	2.4	4.4	0.2	1.2	2.1	1.3	-2.1
Rest time, locomotor task time 2	0.8	1.3	2.2	-1.5	0.6	1.3	0.8	-1.3
Distance moved, locomotor task time 2	0.1	0.2	0.5	0.7	-0.2	-0.3	-0.3	0.3
Vertical activity count, locomotor time 2	0.4	1.0	2.8	1.7	0.8	0.7	0.8	-0.6
Light reinforcement 1	0.7	3.1	3.7	-1.4	-1.8	-1.9	-1.8	1.9
Light reinforcement 2	0.3	0.7	2.7	-1.6	-0.5	-0.4	-0.4	0.3
Bone: marrow area	1.3	3.1	7.9	-2.8	-1.5	-1.3	-1.4	1.3
Bone: maximum diameter	0.2	0.4	1.9	-1.4	-0.0	0.3	0.0	-0.3
Bone: maximum force	0.1	0.2	0.9	-0.9	-0.4	-0.1	-0.4	0.1
Bone: maximum moment	0.1	0.2	1.0	-1.0	-0.3	-0.0	-0.3	0.0
Mean time between licks in bursts	0.6	3.6	5.0	0.7	-1.9	-2.2	-2.0	2.2
Mean num. licks in bursts	0.1	0.3	1.3	1.1	0.1	0.2	0.1	-0.2
Cd content in liver	0.6	0.7	0.8	0.8	0.8	0.8	0.9	-0.8
Co content in liver	1.7	2.0	4.4	-2.1	-1.5	-0.9	-1.4	0.9
Cu content in liver	1.0	1.2	1.5	-1.2	-1.2	-1.0	-1.2	1.0
Fe content in liver	0.0	0.1	0.2	0.5	0.1	0.1	0.1	-0.1
K content in liver	0.7	0.7	2.4	-1.5	0.4	0.7	0.4	-0.7
Mg content in liver	0.9	0.9	4.2	-2.0	-0.5	-0.2	-0.5	0.2
Mn content in liver	0.9	1.0	4.9	-2.2	-0.2	0.1	-0.2	-0.1
Na content in liver	0.1	0.1	0.3	-0.0	0.3	0.5	0.2	-0.5
Rb content in liver	3.6	4.2	5.1	-1.7	-2.2	-2.0	-2.3	2.0
Se content in liver	0.1	0.1	0.2	0.5	0.2	0.2	0.2	-0.2
Sr content in liver	1.1	1.0	1.2	1.1	1.0	0.9	1.0	-0.9
Zn content in liver	0.4	0.4	0.7	0.4	-0.6	-0.8	-0.5	0.8
Bone: minimum diameter	1.5	3.0	3.5	-1.0	-1.8	-1.9	-1.8	1.9
Time in familiar zone, hab. session 1	1.7	1.9	2.6	-1.2	1.2	1.6	1.2	-1.6
Time in novel zone, hab. session 1	1.5	1.7	4.5	2.1	-0.7	-1.2	-0.7	1.2
Total zone transitions, hab. session 1	1.1	1.5	2.0	0.5	-1.4	-1.4	-1.2	1.4
Total locomotion distance, hab. session 1	0.4	0.6	0.9	0.3	-0.8	-0.9	-0.7	0.9
Locomotion velocity, hab. session 1	0.4	0.6	0.9	0.4	-0.8	-0.9	-0.8	0.9
Time in familiar zone, hab. session 2	2.3	2.6	3.7	0.0	1.8	1.9	1.7	-1.9
Time in novel zone, hab. session 2	2.3	2.5	3.6	0.3	-1.7	-1.9	-1.6	1.9
Total zone transitions, hab. session 2	1.3	1.7	7.9	2.8	0.5	-0.1	0.4	0.1
Total locomotion distance, hab. session 2	0.3	0.5	0.7	0.3	-0.6	-0.8	-0.7	0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.4	0.4	-0.4	-0.7	-0.5	0.7
Novel to familiar place preference ratio	0.3	0.4	2.1	1.4	0.2	0.0	0.1	-0.0
Novelty place preference	0.6	0.8	3.6	1.9	0.5	0.2	0.4	-0.2
Time in novel zone, NPP test	0.7	0.8	3.8	1.9	0.5	0.2	0.4	-0.2
Total zone transitions, NPP test	0.4	0.6	2.2	1.5	-0.3	-0.6	-0.3	0.6
Total locomotion distance, NPP test	0.3	0.4	1.9	1.4	-0.2	-0.3	-0.1	0.4
Locomotion velocity, NPP test	0.3	0.4	1.9	1.4	-0.1	-0.3	-0.1	0.4
Intraocular pressure	1.2	2.0	4.3	2.1	-0.9	-1.3	-0.9	1.5
Delta distance traveled before/after self-admin	0.3	0.3	0.4	-0.1	0.6	0.7	0.6	-0.6
Delta ambulatory time before/after self-admin	0.0	0.1	0.1	0.2	0.3	0.3	0.3	-0.3
Parametrial fat weight	0.5	1.1	1.4	-0.6	-1.2	-1.2	-1.1	1.2
Pavlov. Cond. lever latency	0.9	1.1	2.2	1.5	-0.9	-1.1	-0.7	1.0
Pavlov. Cond. magazine entry latency	1.1	1.4	6.3	-2.5	0.0	0.5	0.0	-0.5
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	-0.6	0.5	0.5	0.4	-0.5
Pavlov. Cond. index score	1.9	2.4	4.4	-2.1	1.2	1.6	1.1	-1.6
Pavlov. Cond. latency score	1.8	2.3	5.0	-2.2	1.1	1.5	1.0	-1.5
Pavlov. Cond. lever contacts	0.8	1.0	2.4	-1.6	0.7	0.9	0.6	-0.9
Pavlov. Cond. magazine entry number	1.1	1.4	4.2	2.1	-0.6	-1.0	-0.5	1.0
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	1.0	-0.8	-1.3	-0.9	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.1	-1.7	1.3	1.6	1.2	-1.6
Pavlov. Cond. response bias	1.1	1.4	3.7	-1.9	0.7	1.1	0.6	-1.1
Pavlov. Cond. lever latency	0.7	1.0	1.4	-0.1	1.2	1.1	1.1	-1.1
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	0.0	-0.3	-0.3	-0.3	0.3
Pavlov. Cond. change in total contacts	0.4	1.1	1.5	-0.5	-1.2	-1.1	-1.2	1.1
Pavlov. Cond. index score	0.7	1.1	1.4	0.4	-1.2	-1.2	-1.1	1.2
Pavlov. Cond. latency score	0.9	1.4	1.8	0.2	-1.3	-1.3	-1.2	1.3
Pavlov. Cond. lever contacts	0.5	0.7	1.0	0.4	-1.0	-0.9	-0.9	0.9
Pavlov. Cond. magazine entry number	0.4	0.6	0.7	-0.1	0.9	0.9	0.8	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.0	1.0	0.8	0.7	0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	1.4	-0.1	-1.2	-1.1	-1.1	1.1
Pavlov. Cond. response bias	0.4	0.6	0.9	0.4	-0.9	-0.8	-0.8	0.8
Time in closed arm before self-admin	0.7	1.2	1.7	-0.1	1.2	1.2	1.2	-1.3
Time in closed arm after self-admin	1.1	1.3	4.7	2.2	0.9	0.4	0.8	-0.4
Time in open arm before self-admin	4.5	5.4	10.1	-3.2	-2.4	-1.7	-2.3	1.8
Time in open arm after self-admin	0.4	0.5	1.2	-1.1	-0.7	-0.3	-0.7	0.4
Bone: periosteal estimation	0.7	1.8	4.9	-2.2	-1.2	-0.8	-1.1	0.8
Bone: periosteal perimeter	0.2	0.4	2.0	-1.4	-0.1	0.2	-0.0	-0.2
Bone: post-yield work	2.9	5.1	5.9	-2.4	-2.3	-2.1	-2.3	2.1
Progressive ratio test 1 active lever presses	1.4	2.4	8.1	2.9	1.3	0.8	1.2	-0.6
Progressive ratio test 1 breakpoint	1.6	2.7	9.0	3.0	1.3	0.8	1.2	-0.7
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.6	0.7	-0.1	-0.7	-0.2	0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.7	0.8	0.1	-0.1	0.1	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.6	0.0	-0.2	-0.1	0.1
Progressive ratio test 2 inactive lever presses	0.2	0.5	1.0	0.2	-0.5	-0.9	-0.6	1.0
Incentive Sensitization - Responses	0.2	0.7	0.8	-0.9	-0.9	-0.8	-0.9	0.6
Incentive Sensitization - Breakpoint	0.3	0.7	0.8	-0.8	-0.9	-0.8	-0.9	0.6
Sum of active levers in priming session hrs 5-6	0.7	0.6	0.8	0.9	-0.7	-0.8	-0.7	0.9
Progressive ratio	0.3	0.7	3.0	-1.7	-0.6	-0.1	-0.6	0.1
Food seeking constrained by brief footshock	1.0	1.3	3.1	-1.8	-1.1	-0.5	-1.1	0.5
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.1	-0.5	-0.6	-0.5	0.6
Retroperitoneal fat weight	1.9	8.4	8.7	-2.9	-2.8	-2.9	-3.0	2.9
Reaction time number correct	0.3	0.9	2.7	1.6	0.7	0.6	0.8	-0.7
Reaction time mean minus median	2.1	13.7	15.8	-3.7	-4.0	-3.4	-3.9	3.5
Reaction time mean minus median AUC	2.0	13.5	15.6	-3.3	-4.0	-3.5	-3.9	3.6
Reaction time num false alarms	2.8	4.7	5.1	-2.1	-2.3	-2.1	-2.2	2.2
Reaction time num false alarms AUC	1.3	2.9	3.1	-1.7	-1.8	-1.6	-1.7	1.7
Reaction time trials correct on left	0.3	0.9	2.7	1.6	0.7	0.6	0.8	-0.7
Reaction time trials on left	0.2	0.7	2.5	1.6	0.5	0.5	0.7	-0.5
Reaction time mean	5.8	12.9	28.2	-5.3	-3.2	-2.9	-3.2	2.7
Reaction time mean AUC	5.6	13.4	28.4	-5.3	-3.3	-3.0	-3.3	2.8
Median of all reaction times	5.8	9.1	23.7	-4.9	-2.5	-2.3	-2.5	2.0
Reaction time omissions	9.2	15.0	18.6	-2.8	-4.0	-4.3	-4.0	4.2
Reaction time false alarm rate	3.0	4.1	6.5	-2.5	-2.0	-1.8	-2.0	1.9
Reaction time premature initiation rate	0.9	1.4	2.6	0.8	0.9	1.6	0.8	-1.5
Reaction time premature initiations	0.6	1.8	3.0	1.2	1.0	1.7	1.0	-1.6
Std. dev. reaction times	4.9	16.4	23.7	-4.9	-4.0	-3.6	-4.0	3.6
Reaction time trials completed	0.2	0.7	2.5	1.6	0.5	0.5	0.7	-0.5
Reaction time trials AUC	0.2	0.8	2.7	1.6	0.5	0.4	0.7	-0.5
Run reversals in cocaine runway, females	0.3	0.3	1.3	1.1	0.4	0.0	0.2	0.1
Run reversals in cocaine runway, males	1.2	1.3	6.0	2.5	0.5	-0.0	0.5	0.0
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.2	-0.1	0.0	0.0	0.1
Latency to leave start box in cocaine runway, F	0.5	0.6	1.4	1.2	0.7	0.7	0.8	-0.6
Latency to leave start box in cocaine runway, M	1.4	1.3	2.6	-1.6	-1.2	-0.9	-1.0	0.9
Std. dev. time between licks in bursts	4.1	7.8	9.8	-1.4	-3.1	-3.0	-3.1	3.0
Total sessions with >9 infusions	1.2	1.5	7.2	2.7	0.5	-0.1	0.4	-0.1
Short access day 1 total inactive lever presses	1.1	2.1	8.6	2.9	0.9	0.7	0.8	-0.5
Short access day 10 total inactive lever presses	0.4	3.0	13.4	-3.7	-0.7	-0.5	-0.9	0.3
Short access day 1 total infusions	2.0	4.0	16.6	4.1	1.3	0.4	1.2	-0.5
Short access day 10 total infusions	1.8	2.9	9.9	3.1	1.4	0.8	1.3	-0.8
Short access total infusions	1.5	2.1	7.2	2.7	1.1	0.7	1.1	-0.7
Short access day 1 locomotion	1.0	1.6	6.9	2.6	0.8	0.3	0.7	-0.3
Short access day 10 total locomotion	0.0	0.1	0.2	-0.1	0.4	-0.1	0.4	-0.2
Short access total locomotion	0.1	0.1	0.2	0.3	0.4	0.0	0.4	-0.2
One hour access (0.3 mA shock)	0.4	0.5	1.7	1.3	0.7	0.1	0.6	-0.3
Compulsive drug intake	0.4	0.6	2.6	-1.6	-0.2	0.3	-0.3	-0.6
One hour access (shock baseline)	0.7	1.8	7.9	2.8	0.7	0.0	0.7	0.1
Social response proportion	0.4	0.5	1.4	1.2	-0.8	-0.5	-0.5	0.4
Social responses	0.6	0.7	2.3	1.5	-0.8	-0.4	-0.6	0.5
Social time	0.5	0.8	1.3	0.5	-1.1	-0.9	-0.9	0.9
Soleus weight	0.1	0.3	0.4	-0.4	0.6	0.5	0.5	-0.5
Bone: stiffness	0.1	0.2	0.4	-0.3	0.4	0.6	0.3	-0.6
Tibialis anterior weight	0.0	0.1	0.1	0.2	0.3	0.3	0.3	-0.3
Time to tail flick, vehicle, before self-admin	0.6	0.8	1.4	-0.9	-1.0	-0.5	-1.2	0.6
Time to tail flick, vehicle, after self-admin	0.8	1.7	2.6	-0.6	-1.6	-1.3	-1.5	1.3
Time to tail flick, test, before self-admin	3.0	3.5	4.0	-2.0	-1.8	-1.9	-1.8	1.9
Time to tail flick, test, after self-admin	1.0	1.1	1.6	-1.2	-1.0	-1.1	-0.9	1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.5	0.2	0.1	0.3	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	0.2	0.2	0.3	-0.3
Tibia length	0.7	2.1	2.9	1.7	1.5	1.2	1.5	-1.2
Ambulatory time before self-admin	0.3	0.9	2.9	1.7	-0.5	-0.8	-0.4	0.8
Ambulatory time after self-admin	0.4	0.7	3.0	1.7	-0.1	-0.3	0.0	0.5
Bone: tissue strength	0.9	0.9	1.0	1.0	0.9	1.0	0.9	-1.0
Total heroin consumption	2.4	2.9	13.5	-3.7	-0.6	0.5	-0.3	-0.3
Bone: trabecular number	1.0	1.8	2.5	0.4	1.4	1.5	1.6	-1.5
Bone: trabecular spacing	0.8	1.2	4.2	2.0	-0.4	-0.7	-0.7	0.7
Bone: trabecular thickness	2.9	4.0	5.3	0.8	2.0	2.2	2.3	-2.2
Bone: trabecular tissue density	1.0	1.7	2.3	0.3	1.4	1.5	1.4	-1.5
Water consumed over 24 hours	1.2	2.4	11.5	-3.4	-0.5	0.2	-0.4	-0.2
Number of responses in last shaping day	2.4	3.1	11.6	3.4	1.3	0.5	1.3	-0.4