LOC134483824

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134483824	0.17	0.09	1.7e-08	0.06	0.07	0.08	0.06	8.9e-07	5.4e-08	6.0e-09	9.2e-08
2	Brain	gene expression	LOC134483824	0.05	0.04	1.0e-03	0.04	0.04	0.02	0.04	7.0e-05	3.1e-04	2.2e-03	1.2e-04
3	Liver	gene expression	LOC134483824	0.19	0.1	1.5e-08	0.07	0.07	0.06	0.07	1.0e-08	1.3e-08	1.5e-07	3.9e-08
4	pVTA	gene expression	LOC134483824	0.05	0.04	2.7e-03	0.02	0.03	0.01	0.02	7.5e-03	3.6e-03	3.7e-02	7.8e-03
5	PL	gene expression	LOC134483824	0.04	0.03	3.3e-03	0.03	0.02	0.01	0.03	3.1e-04	1.3e-03	1.4e-02	7.2e-04
6	NAcc	gene expression	LOC134483824	0.06	0.04	8.7e-08	0.05	0.05	0.05	0.05	6.2e-08	1.7e-08	1.8e-08	1.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.3	1.1	-0.2	-1.1	0.1	0.6	-0.3	0.2
Area under the delay curve	0.6	1.0	2.1	0.3	-1.4	0.9	1.5	-0.5	0.7
BMI with tail	0.5	1.7	3.2	-0.2	-1.1	-0.8	1.6	-1.5	1.8
BMI without tail	0.1	0.6	1.8	0.8	-1.3	0.7	1.0	0.1	0.2
Body weight	0.2	0.8	2.3	-0.5	-1.5	0.6	1.2	-0.5	0.6
Weight adjusted by age	0.2	0.5	1.0	-0.8	-0.5	-1.0	0.4	-0.7	0.7
Bone surface	0.3	0.5	0.8	0.5	-0.9	-0.3	0.9	-0.7	0.8
Bone volume	0.2	0.5	1.6	0.4	-1.3	-0.0	0.8	-0.5	0.4
Breakpoint value in progressive ratio session	3.0	5.5	31.5	5.6	0.1	-0.7	0.1	-0.9	0.4
Number of licking bursts	2.7	8.2	14.2	-3.3	1.1	3.3	-1.6	3.8	-3.1
Context. condit. distance diff. score	0.5	0.6	3.7	1.9	0.0	-0.2	-0.2	-0.0	-0.2
Locomotion velocity, session 1	2.1	2.3	5.8	-2.0	2.4	-0.5	-1.7	0.8	-0.8
Locomotion distance, session 1	1.4	1.8	4.5	1.3	2.1	-0.4	-1.6	0.9	-0.9
Locomotion velocity, session 2	0.9	1.1	2.3	1.5	1.0	-1.5	-0.2	-0.7	0.8
Locomotion distance, session 2	0.6	0.8	2.8	0.2	1.7	0.0	-1.0	0.9	-0.6
Locomotion velocity, session 3	1.0	1.1	3.5	1.9	1.0	-1.3	-0.3	-0.5	0.5
Locomotion distance, session 3	0.7	0.8	3.4	1.8	0.6	0.2	-0.7	0.5	-0.7
Stereotopy head waving bouts, day 3	0.8	1.0	5.2	-2.3	-0.1	0.6	0.1	0.3	-0.2
Stereotopy head waving duration, day 3	0.6	0.8	1.8	-1.3	-0.4	-0.7	0.6	-1.1	0.9
Locomotion velocity, session 7	1.8	2.0	9.5	3.1	-0.3	-1.1	-0.3	-1.1	0.1
Locomotion distance, session 7	1.2	1.6	8.6	2.9	-0.7	0.3	-0.1	-0.1	-0.5
Stereotopy head waving bouts, day 7	0.3	0.3	1.0	-0.1	0.5	-1.0	0.0	-0.6	0.7
Stereotopy head waving duration, day 7	0.8	1.0	3.0	0.2	0.9	-1.7	-0.0	-1.1	1.1
Locomotion velocity, session 8	0.3	0.3	1.0	-0.5	1.0	-0.0	-0.6	0.6	-0.3
Locomotion distance, session 8	1.0	1.5	6.9	2.6	0.9	-1.0	-0.3	-0.3	0.4
Degree of sensitization distance	0.3	0.4	0.5	0.5	-0.7	-0.6	0.5	-0.7	0.6
Degree of sensitization stereotypy	0.3	0.4	1.0	0.3	0.6	-1.0	0.1	-0.5	0.7
Conditioned locomotion	0.5	0.5	1.0	-0.2	0.7	-1.0	0.2	-0.9	1.0
Cocaine response after cond. corrected	0.6	0.9	1.6	1.3	-0.1	-0.9	0.8	-0.7	1.3
Cocaine response after cond. not corrected	1.8	2.6	4.5	2.1	-0.8	-1.5	1.3	-1.6	1.9
Cocaine response before conditioning	1.2	1.4	3.0	1.4	-1.0	-1.3	0.4	-1.7	0.8
Saline control response	0.7	1.0	2.7	-0.1	-1.0	1.6	-0.1	0.8	-1.2
Bone: connectivity density	0.1	0.2	1.1	1.1	-0.3	0.2	0.1	0.1	-0.2
Bone: cortical apparent density	4.4	6.9	32.6	5.7	-2.6	0.8	1.3	-0.3	0.1
Bone: cortical area	0.7	1.1	4.3	2.1	-0.8	-0.3	0.8	-0.7	0.7
Bone: cortical porosity	2.9	3.1	9.2	-3.0	1.4	-2.1	-0.2	-1.1	1.3
Bone: cortical porosity	2.2	2.4	7.6	-2.8	1.2	-1.8	-0.0	-0.9	1.2
Bone: cortical thickness	1.3	2.1	6.9	2.6	-1.2	-0.9	0.8	-1.4	0.9
Bone: cortical thickness	0.2	0.3	1.1	-1.0	-0.3	-0.1	0.4	-0.4	0.4
Bone: cortical tissue density	4.3	6.8	31.2	5.6	-2.6	0.9	1.3	-0.3	0.2
Condit. Reinf. active minus inactive responses	1.3	1.5	7.8	2.8	0.5	-0.9	-0.4	-0.2	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.3	1.1	0.1	0.1	-0.0	0.1	-0.1
Condit. Reinf. active responses	0.9	1.1	5.5	2.3	0.3	-0.8	-0.5	-0.2	-0.0
Condit. Reinf. inactive responses	0.3	0.3	1.2	1.1	0.1	-0.7	-0.5	-0.1	-0.1
Incentive salience index mean	1.6	2.0	8.8	3.0	0.6	-1.5	-0.4	-0.7	0.5
Condit. Reinf. lever presses	1.3	1.9	7.0	2.6	0.3	-1.7	-0.2	-1.0	0.7
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.0	0.2	-0.2	-0.3	0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.4	0.7	1.5	1.0	1.2	-0.4	-1.0	0.5	-0.5
Condit. Reinf. active responses	0.3	0.5	0.7	-0.8	-0.8	-0.1	0.8	-0.6	0.7
Condit. Reinf. inactive responses	1.2	1.8	3.8	-1.9	-2.0	0.5	1.4	-0.7	0.6
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.4	-0.8	-0.3	0.7	-0.6	0.7
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	-0.7	-0.7	-0.0	0.5	-0.4	0.3
Conditioned reinforcement - actives	0.3	1.3	4.3	-2.1	0.5	1.3	0.0	1.2	-0.5
Conditioned reinforcement - inactives	0.6	1.5	3.8	-2.0	-1.3	0.9	1.5	-0.2	0.8
Conditioned locomotion	2.1	3.2	17.4	-4.2	-0.1	1.1	0.6	0.4	0.1
Patch foraging indifference point 0 sec	0.4	1.0	3.5	1.9	-1.2	0.4	0.7	-0.7	0.2
Patch foraging indifference point AUC	0.2	0.4	1.6	1.3	-0.6	-0.1	0.4	-0.4	0.3
Delay disc. indifference point, 0s delay	2.6	2.9	7.7	-2.8	-1.7	1.4	1.9	-0.4	0.9
Delay disc. indifference point, 16s delay	0.3	0.5	0.8	0.8	-0.9	0.8	0.8	-0.1	0.3
Delay disc. indifference point, 2s delay	0.5	0.6	1.7	-0.2	-1.3	0.7	0.9	-0.7	0.3
Delay disc. indifference point, 24s delay	0.3	0.5	1.1	-1.1	-0.9	0.9	0.7	0.2	0.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	-0.1	-0.6	0.2	1.0	-0.4	0.6
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	0.3	-0.6	0.6	0.6	-0.0	0.2
Indifference point function ln k	0.3	0.9	5.0	-2.2	0.4	0.3	-0.2	0.5	-0.2
Indifference point function log k	0.3	0.9	5.0	-2.2	0.4	0.3	-0.2	0.5	-0.2
Patch foraging total patch changes 0 sec	0.3	0.9	3.6	1.9	-1.0	0.1	0.5	-0.9	0.3
Patch foraging total patch changes 12 sec	1.6	2.2	8.0	2.8	-1.6	0.6	1.2	-0.5	0.5
Patch foraging total patch changes 18 sec	1.1	2.6	6.4	2.5	-1.8	-0.5	1.3	-1.7	1.1
Patch foraging total patch changes 24 sec	0.4	1.4	7.6	2.8	0.2	0.1	-0.5	0.2	-0.6
Patch foraging total patch changes 6 sec	0.4	0.7	1.7	0.8	-1.3	0.2	0.9	-0.8	0.5
Patch foraging time to switch 0 sec	0.2	0.6	1.4	-0.7	1.1	-1.2	-0.5	-0.4	0.4
Patch foraging water rate 0 sec	0.2	0.6	1.9	1.4	-1.0	0.7	0.3	0.1	-0.3
Patch foraging water rate 12 sec	0.0	0.1	0.5	-0.0	-0.7	0.1	0.5	-0.1	0.3
Patch foraging water rate 18 sec	0.4	0.8	1.9	-1.4	-1.0	0.1	1.1	-0.3	1.0
Patch foraging water rate 24 sec	0.5	0.7	2.3	-0.4	-1.5	1.1	0.6	0.4	-0.3
Patch foraging water rate 6 sec	0.3	0.5	1.0	-0.5	-0.3	1.0	-0.2	0.9	-0.8
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.3	1.1	1.0	0.1	-0.9	0.5	-0.8
Distance traveled before self-admin	0.1	0.3	1.0	-1.0	-0.7	0.3	0.6	0.0	0.2
Distance traveled after self-admin	0.7	1.2	5.0	-2.2	-1.2	0.1	0.8	-0.3	0.5
Extensor digitorum longus weight	0.1	0.4	1.9	-1.4	-0.1	0.3	-0.3	0.5	-0.6
Bone: elastic displacement	0.8	1.1	3.2	1.8	-1.0	1.1	0.3	0.7	-0.6
Bone: elastic work	0.6	0.8	1.8	0.7	-0.9	1.3	0.3	1.0	-0.7
Bone: endosteal estimation	0.6	1.4	6.3	-2.5	0.9	0.2	-0.5	0.7	-0.4
Bone: endosteal perimeter	0.3	0.8	1.9	1.1	1.4	-0.1	-0.8	0.6	-0.5
Epididymis fat weight	0.0	0.2	0.4	-0.4	-0.5	0.5	-0.2	0.4	-0.7
Delta time in closed arm before/after self-admin	2.0	1.9	6.7	-2.6	-1.0	1.1	1.4	0.1	0.7
Delta time in open arm before/after self-admin	0.3	0.4	1.7	1.3	-0.3	-0.3	0.1	-0.6	0.2
Diff in mean of infusions in LGA sessions	1.2	2.1	4.8	2.2	-0.2	-1.7	0.6	-1.8	1.3
Delay discount exponential model param	0.5	0.7	1.6	-0.4	1.2	-0.8	-1.3	0.4	-0.6
Extinction: sum of active levers before priming	2.3	3.6	20.2	4.5	-0.5	0.1	0.4	-0.7	0.3
Active lever presses in extinction session 6	1.7	1.7	7.4	2.7	-1.0	0.1	0.8	-0.8	0.7
Bone: final force	0.5	0.8	4.3	2.1	-0.4	0.2	0.2	0.1	-0.1
Bone: final moment	0.4	0.6	3.7	1.9	-0.2	0.2	-0.0	0.2	-0.2
Food consumed during 24 hour testing period	1.0	1.9	5.0	-1.4	-0.5	2.2	-0.3	1.5	-1.5
Glucose	0.4	0.6	1.2	-0.2	-0.5	-0.8	0.7	-1.1	1.1
Heart weight	0.2	0.4	0.9	0.4	-0.1	0.8	-0.4	0.7	-1.0
Delay discount hyperbolic model param	0.6	0.8	1.7	-0.6	1.2	-0.5	-1.3	0.6	-0.8
Intermittent access intake day 1-15 change	0.1	0.7	1.7	1.1	-1.3	0.4	0.9	-0.4	0.5
Intermittent access intake escalation	0.1	0.8	2.2	0.6	-1.5	0.5	1.2	-0.4	0.7
Intermittent access intake escalation 2	0.3	0.4	1.2	0.5	-1.1	0.8	0.7	-0.2	0.3
Intermitt. access day 1 inactive lever presses	0.1	1.1	6.1	2.5	-0.4	-0.0	-0.1	-0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.6	3.2	13.6	-3.7	-1.2	1.6	0.2	0.8	-0.9
Intermitt. access escalation Index	0.7	2.3	5.7	-2.4	0.5	-2.4	-0.1	-1.1	1.0
Intermittent access day 1 total infusions	0.2	0.7	2.1	-1.4	-0.7	0.9	0.8	0.1	0.3
Intermittent access day 15 total infusions	1.1	2.7	5.5	-2.4	-2.1	1.1	1.9	-0.6	1.0
Intermittent access terminal intake (last 3 days)	1.5	2.6	5.5	-1.4	-2.3	1.9	1.9	-0.3	0.8
Intermittent access total infusions	2.9	3.5	9.9	-3.1	-2.0	1.8	1.8	-0.1	0.7
Intermittent access day 1 locomotion	0.8	1.6	5.6	-2.4	-1.0	0.9	1.2	-0.1	0.7
Intermittent access day 15 total locomotion	0.3	1.1	3.2	-1.1	-0.7	1.8	0.5	1.1	-0.5
Intermittent access total locomotion	1.2	1.5	4.4	-2.1	-0.9	1.5	1.0	0.3	0.2
Intermittent access standard deviation	0.4	2.3	4.3	-1.9	-1.9	2.1	1.4	0.0	0.2
Left kidney weight	0.1	0.8	2.9	1.7	-0.4	-0.8	0.3	-0.7	0.6
Right kidney weight	0.2	1.6	2.7	1.6	-1.1	-0.7	1.1	-1.5	1.3
Cocaine induced anxiety	0.2	0.6	2.3	1.5	0.6	0.3	-0.7	0.3	-0.7
Post-drug Anxiety	0.6	0.7	3.8	1.9	-0.1	-0.0	0.2	-0.4	0.2
Baseline Anxiety	0.1	0.1	0.4	0.6	0.2	0.1	-0.2	0.3	-0.4
Tail length	0.4	2.3	4.0	1.6	-0.1	1.8	-1.0	1.7	-2.0
Length with tail	0.3	1.5	3.0	0.9	-0.4	1.7	-0.7	1.3	-1.6
Length without tail	0.1	0.4	2.5	-1.6	0.1	-0.2	-0.1	-0.2	0.1
Times rat made contact with spout	7.5	8.6	17.6	-4.2	-0.4	3.8	-0.8	3.2	-2.9
Lifetime Intake	2.6	3.3	11.8	-3.4	-1.7	1.0	1.7	-0.5	1.0
Liver weight, left	0.8	1.4	3.5	1.9	1.1	0.1	-1.3	0.8	-1.1
Liver weight, right	2.6	4.6	12.2	-3.5	1.7	1.0	-1.9	2.0	-2.0
Locomotor activity	0.2	0.3	1.5	-1.2	0.3	-0.4	-0.0	-0.1	0.1
Locomotor testing distance	0.1	0.3	0.7	0.3	0.8	-0.4	-0.7	0.4	-0.4
Locomotor testing rearing	0.5	1.7	7.0	2.6	0.1	0.7	-0.8	0.8	-1.1
Locomotion in novel chamber	0.0	0.1	0.1	0.4	0.3	-0.1	-0.3	-0.2	-0.1
Locomotion in novel chamber post-restriction	0.2	0.6	1.3	-0.6	0.5	1.0	-0.4	1.1	-0.8
Fecal boli incidents, locomotor time 1	0.2	0.5	2.2	1.5	0.5	-0.2	-0.3	0.3	-0.2
Change in fecal boli incidents, locomotor task	0.8	0.9	1.6	-1.3	-1.0	-0.2	0.9	-1.0	0.8
Time >=10cm from walls, locomotor time 1	1.2	1.5	2.3	0.8	-1.2	-0.4	1.5	-1.4	1.5
Bouts of movement, locomotor time 1	0.4	0.5	1.6	0.3	-0.1	-1.3	-0.2	-1.1	0.3
Total resting periods, locomotor time 1	0.3	0.4	1.4	0.3	0.0	-1.2	-0.2	-0.9	0.2
Rest time, locomotor task time 1	0.2	0.4	1.1	1.1	-0.0	-0.8	0.1	-0.6	0.4
Distance moved, locomotor task time 1	0.1	0.4	0.6	0.5	-0.7	-0.0	0.8	-0.7	0.8
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.3	-0.0	0.3	0.3	0.2	0.2
Time >=10cm from walls, locomotor time 2	0.6	1.8	3.2	0.6	-1.5	-0.3	1.8	-1.4	1.7
Bouts of movement, locomotor time 2	0.1	0.4	0.7	-0.1	-0.2	-0.8	0.4	-0.8	0.8
Total resting periods, locomotor time 2	0.1	0.2	0.4	-0.2	-0.1	-0.7	0.3	-0.6	0.6
Rest time, locomotor task time 2	0.1	0.1	0.4	0.7	-0.0	-0.4	0.1	-0.3	0.2
Distance moved, locomotor task time 2	0.6	0.8	1.2	1.0	-0.5	-0.8	0.7	-1.1	1.0
Vertical activity count, locomotor time 2	0.5	1.1	2.4	0.7	-1.0	0.0	1.5	-0.8	1.4
Light reinforcement 1	0.1	0.5	2.2	1.5	0.1	-0.8	-0.2	-0.6	0.2
Light reinforcement 2	0.4	0.9	2.5	-1.6	-1.0	1.1	0.6	0.6	-0.2
Bone: marrow area	0.5	1.3	5.7	-2.4	0.9	0.2	-0.5	0.7	-0.4
Bone: maximum diameter	0.4	0.7	1.6	-1.3	0.4	1.0	-0.3	1.0	-0.7
Bone: maximum force	0.2	0.4	1.8	1.3	-0.1	0.5	-0.2	0.6	-0.5
Bone: maximum moment	0.2	0.4	1.3	1.1	0.0	0.5	-0.3	0.7	-0.6
Mean time between licks in bursts	0.2	1.3	2.2	1.1	-0.1	-1.5	0.7	-1.4	1.4
Mean num. licks in bursts	0.7	1.8	3.2	1.2	-1.4	-0.9	1.2	-1.8	1.3
Cd content in liver	2.7	3.0	11.2	-3.3	0.1	1.7	-0.4	1.4	-1.3
Co content in liver	4.4	5.2	15.3	-3.9	-1.3	-0.8	2.2	-1.8	2.4
Cu content in liver	1.0	1.2	2.6	-1.3	-1.6	0.2	1.2	-1.0	0.7
Fe content in liver	1.3	1.7	8.7	2.9	-0.4	0.3	-0.4	0.4	-0.8
K content in liver	0.6	0.6	1.7	0.3	-0.0	-1.2	-0.2	-1.3	0.4
Mg content in liver	0.6	0.7	1.5	-1.2	-0.8	-0.2	0.8	-0.9	0.7
Mn content in liver	0.5	0.6	1.5	-0.9	-1.2	0.3	0.8	-0.6	0.3
Na content in liver	0.5	0.6	1.1	0.7	0.8	0.1	-1.1	0.5	-1.0
Rb content in liver	0.6	0.7	3.2	-0.5	-1.8	0.4	0.8	-0.5	0.1
Se content in liver	0.1	0.1	0.5	-0.7	0.1	0.2	0.1	-0.0	0.0
Sr content in liver	1.6	1.4	7.7	-2.8	0.7	0.2	-0.3	0.4	-0.3
Zn content in liver	2.8	3.2	10.9	-3.3	-1.6	0.1	1.6	-1.2	1.2
Bone: minimum diameter	1.2	2.4	11.6	3.4	0.1	-1.1	0.2	-0.9	0.7
Time in familiar zone, hab. session 1	0.3	0.3	1.4	-1.2	-0.1	0.2	0.5	-0.1	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.6	0.2	0.4	-0.6	0.6	-0.8
Total zone transitions, hab. session 1	1.6	2.2	6.2	-2.5	-0.1	2.0	0.2	1.5	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.8	0.5	0.6	-0.4	0.7	-0.6
Locomotion velocity, hab. session 1	0.2	0.3	0.8	-0.1	0.9	-0.0	-0.8	0.4	-0.6
Time in familiar zone, hab. session 2	0.4	0.5	2.5	1.6	0.1	-0.3	-0.0	-0.4	0.1
Time in novel zone, hab. session 2	0.3	0.3	1.2	-1.1	0.1	0.2	-0.3	0.3	-0.4
Total zone transitions, hab. session 2	0.3	0.4	1.6	1.3	0.5	0.4	-0.2	0.6	-0.3
Total locomotion distance, hab. session 2	0.9	1.2	5.8	2.4	0.6	-0.8	-0.4	-0.3	0.1
Locomotion velocity, hab. session 2	0.7	0.9	5.0	2.2	0.4	-0.6	-0.3	-0.2	0.1
Novel to familiar place preference ratio	2.3	3.0	5.5	0.6	-0.9	-2.3	1.2	-2.3	2.1
Novelty place preference	2.2	2.8	6.0	0.6	-0.6	-2.5	0.9	-2.3	2.0
Time in novel zone, NPP test	1.5	1.9	4.6	0.4	-0.3	-2.1	0.6	-1.8	1.6
Total zone transitions, NPP test	0.2	0.3	0.7	-0.4	0.9	0.3	-0.5	0.7	-0.4
Total locomotion distance, NPP test	0.8	1.1	3.1	1.8	1.1	-1.0	-1.0	-0.1	-0.3
Locomotion velocity, NPP test	0.8	1.1	3.9	2.0	0.7	-1.2	-0.6	-0.5	0.1
Intraocular pressure	0.8	1.3	4.3	0.9	-2.1	0.4	1.3	-0.8	0.6
Delta distance traveled before/after self-admin	1.9	2.1	4.5	-2.1	-1.4	-0.8	1.3	-1.4	1.4
Delta ambulatory time before/after self-admin	0.4	0.7	2.3	-1.5	-1.0	0.0	0.5	-0.5	0.4
Parametrial fat weight	1.7	4.0	20.5	4.5	0.1	0.4	-1.1	0.5	-1.3
Pavlov. Cond. lever latency	0.8	1.0	3.2	-0.6	-0.3	1.8	0.2	1.3	-0.7
Pavlov. Cond. magazine entry latency	0.9	1.2	2.9	0.7	1.4	-0.6	-1.7	0.3	-1.1
Pavlov. Cond. change in total contacts	0.4	0.4	1.1	0.7	0.1	-1.1	-0.6	-0.6	-0.0
Pavlov. Cond. index score	0.7	0.9	2.2	0.6	1.0	-1.5	-1.1	-0.6	-0.2
Pavlov. Cond. latency score	0.8	1.0	2.8	0.8	0.9	-1.7	-1.0	-0.8	0.0
Pavlov. Cond. lever contacts	0.5	0.6	2.0	0.7	0.4	-1.4	-0.5	-0.9	0.3
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.4	-1.0	0.4	1.1	-0.3	0.6
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.4	1.1	-0.8	-0.3	1.2	-0.5	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.9	0.4	0.7	-1.4	-0.9	-0.8	-0.1
Pavlov. Cond. response bias	0.3	0.4	0.9	0.3	0.7	-0.7	-0.9	-0.1	-0.4
Pavlov. Cond. lever latency	1.5	2.1	2.9	-0.6	1.7	1.0	-1.7	1.7	-1.7
Pavlov. Cond. magazine entry latency	1.3	1.8	3.2	1.8	-1.1	-0.8	1.3	-1.4	1.4
Pavlov. Cond. change in total contacts	1.5	3.6	7.8	-1.6	-2.8	0.1	2.5	-1.4	1.8
Pavlov. Cond. index score	1.1	1.8	3.2	0.7	-1.8	-0.4	1.7	-1.4	1.4
Pavlov. Cond. latency score	1.0	1.6	2.7	0.9	-1.7	-0.5	1.5	-1.3	1.3
Pavlov. Cond. lever contacts	1.2	1.7	2.7	0.8	-1.6	-0.6	1.6	-1.3	1.5
Pavlov. Cond. magazine entry number	0.9	1.1	2.2	-1.5	0.9	0.6	-1.1	1.0	-1.1
Pavlov. Cond. intertrial magazine entries	0.6	1.4	3.1	0.4	-0.6	-1.7	0.5	-1.8	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.6	2.5	0.8	-1.6	-0.5	1.5	-1.4	1.4
Pavlov. Cond. response bias	1.8	2.5	3.6	0.7	-1.7	-1.0	1.8	-1.8	1.9
Time in closed arm before self-admin	1.6	2.8	11.7	3.4	1.1	-0.5	-1.5	0.5	-1.1
Time in closed arm after self-admin	0.2	0.3	0.9	0.4	0.3	0.6	-0.1	1.0	-0.4
Time in open arm before self-admin	0.8	1.0	3.2	-1.8	-1.0	0.9	0.9	0.3	0.4
Time in open arm after self-admin	0.4	0.5	1.2	0.3	-1.1	0.5	0.9	-0.5	0.5
Bone: periosteal estimation	0.0	0.0	0.0	-0.0	0.2	0.1	-0.1	0.2	-0.2
Bone: periosteal perimeter	0.6	1.2	7.4	2.7	-0.1	0.0	0.0	-0.0	-0.1
Bone: post-yield work	0.8	1.4	3.1	0.4	1.2	1.1	-1.1	1.8	-1.3
Progressive ratio test 1 active lever presses	2.1	3.7	18.0	-4.2	-1.1	1.4	0.8	0.5	-0.1
Progressive ratio test 1 breakpoint	2.3	4.0	20.1	-4.5	-1.0	1.4	0.7	0.6	-0.1
Progressive ratio test 1 inactive lever presses	0.8	2.0	10.1	-3.2	-0.8	1.0	0.2	0.2	-0.3
Progressive ratio test 2 active lever presses	1.6	2.2	4.6	1.2	-1.9	2.2	1.9	-0.2	0.5
Progressive ratio test 2 breakpoint	1.6	2.0	4.9	0.9	-1.8	2.2	1.8	-0.1	0.4
Progressive ratio test 2 inactive lever presses	0.6	2.1	4.7	-0.3	-2.2	1.5	2.1	-0.6	0.9
Incentive Sensitization - Responses	1.2	3.3	7.9	2.5	-1.7	2.8	1.5	0.5	-0.2
Incentive Sensitization - Breakpoint	1.4	3.2	7.9	2.5	-1.6	2.8	1.5	0.5	-0.2
Sum of active levers in priming session hrs 5-6	1.3	1.2	6.2	2.5	-0.5	-0.0	0.3	-0.7	0.3
Progressive ratio	1.0	2.9	10.0	3.2	1.6	-0.3	-1.7	0.7	-1.3
Food seeking constrained by brief footshock	0.7	0.8	4.3	-2.1	-0.3	0.5	0.4	0.3	-0.0
Seeking ratio, punishment vs. effort	1.2	2.7	6.1	-2.5	-1.9	0.5	1.9	-0.8	1.4
Retroperitoneal fat weight	0.0	0.2	0.6	0.8	-0.7	0.5	0.2	-0.1	-0.2
Reaction time number correct	0.8	2.8	9.6	-3.1	-1.7	0.7	1.7	-0.3	1.0
Reaction time mean minus median	0.1	0.5	0.9	0.9	0.3	0.9	-0.3	1.0	-0.6
Reaction time mean minus median AUC	0.1	0.6	1.4	1.0	-0.2	1.2	0.1	1.1	-0.5
Reaction time num false alarms	1.7	2.9	16.6	4.1	-0.2	-0.4	-0.4	-0.7	-0.2
Reaction time num false alarms AUC	1.1	2.4	13.8	3.7	-0.4	-0.1	-0.2	-0.6	-0.2
Reaction time trials correct on left	0.8	2.8	9.6	-3.1	-1.7	0.7	1.7	-0.3	1.0
Reaction time trials on left	0.8	2.6	8.5	-2.9	-1.7	0.7	1.7	-0.3	1.0
Reaction time mean	1.2	2.6	4.2	1.3	2.0	0.9	-1.7	2.0	-1.6
Reaction time mean AUC	0.8	1.9	3.1	1.1	1.7	0.9	-1.4	1.7	-1.3
Median of all reaction times	1.5	2.3	4.4	1.0	2.1	0.7	-1.7	1.8	-1.5
Reaction time omissions	1.7	2.8	16.4	4.0	0.6	-0.2	-0.3	0.3	-0.0
Reaction time false alarm rate	3.0	4.2	22.5	4.7	0.6	-0.5	-1.1	-0.3	-0.8
Reaction time premature initiation rate	2.9	4.6	11.3	1.1	3.4	-0.5	-3.0	1.4	-1.9
Reaction time premature initiations	0.5	1.6	4.5	0.1	2.1	-0.3	-1.7	1.0	-1.1
Std. dev. reaction times	0.7	2.3	6.7	2.6	1.4	0.8	-1.1	1.5	-1.1
Reaction time trials completed	0.8	2.6	8.5	-2.9	-1.7	0.7	1.7	-0.3	1.0
Reaction time trials AUC	0.8	2.8	8.3	-2.9	-1.8	0.7	1.9	-0.4	1.1
Run reversals in cocaine runway, females	1.5	1.7	2.5	-1.6	-1.1	-0.7	1.5	-1.1	1.6
Run reversals in cocaine runway, males	0.2	0.2	1.0	1.0	0.1	0.3	0.3	0.3	0.2
Latency to leave start box in cocaine runway	2.9	4.0	6.5	2.0	-1.2	-1.9	1.8	-2.3	2.5
Latency to leave start box in cocaine runway, F	2.9	3.6	5.3	2.3	-1.6	-1.2	1.8	-2.0	2.2
Latency to leave start box in cocaine runway, M	0.7	0.7	1.7	-0.0	-0.1	-0.9	0.8	-1.0	1.3
Std. dev. time between licks in bursts	0.3	0.6	1.3	0.0	0.8	0.7	-0.6	1.2	-0.8
Total sessions with >9 infusions	2.9	3.7	18.2	-4.3	-1.1	0.4	1.2	-0.4	0.8
Short access day 1 total inactive lever presses	1.1	2.3	10.1	-3.2	-0.7	1.4	0.4	0.9	-0.4
Short access day 10 total inactive lever presses	0.3	1.9	3.4	-1.4	0.8	1.0	-1.4	1.5	-1.9
Short access day 1 total infusions	4.1	8.1	44.5	-6.7	-1.0	0.0	1.3	-0.5	1.1
Short access day 10 total infusions	2.2	3.6	17.8	-4.2	-1.2	1.0	0.9	-0.2	0.3
Short access total infusions	3.3	4.7	24.7	-5.0	-0.9	-0.1	1.1	-0.7	1.0
Short access day 1 locomotion	3.2	5.3	31.9	-5.6	-0.1	0.3	0.2	0.1	0.1
Short access day 10 total locomotion	0.5	1.9	10.7	-3.3	-0.3	0.1	0.5	-0.2	0.4
Short access total locomotion	1.1	1.7	9.0	-3.0	-0.4	-0.1	0.6	-0.4	0.6
One hour access (0.3 mA shock)	0.2	0.2	0.5	-0.1	-0.6	0.7	0.6	-0.1	0.3
Compulsive drug intake	2.2	3.2	17.0	-4.1	0.8	-0.8	-0.8	0.3	-0.2
One hour access (shock baseline)	0.9	2.3	10.2	3.2	-1.1	0.8	1.1	-0.6	0.6
Social response proportion	0.6	0.8	4.6	-2.1	-0.4	0.4	0.2	0.0	-0.1
Social responses	0.2	0.3	0.8	-0.9	-0.8	-0.2	0.3	-0.5	0.1
Social time	0.3	0.5	1.4	-0.1	-0.7	1.2	-0.0	0.7	-0.8
Soleus weight	0.1	0.3	0.7	0.8	0.5	0.1	-0.3	0.8	-0.2
Bone: stiffness	0.2	0.3	1.1	0.1	1.1	-0.2	-0.7	0.4	-0.4
Tibialis anterior weight	1.1	3.7	8.4	-2.3	-1.5	2.9	0.5	2.1	-1.3
Time to tail flick, vehicle, before self-admin	0.7	0.9	1.8	0.2	1.0	0.3	-1.3	0.7	-1.3
Time to tail flick, vehicle, after self-admin	1.3	2.6	5.6	-2.4	-1.7	-0.3	1.7	-1.4	1.5
Time to tail flick, test, before self-admin	0.4	0.4	0.9	0.3	0.8	-0.9	-0.9	-0.1	-0.3
Time to tail flick, test, after self-admin	0.3	0.4	0.9	-1.0	-0.1	0.5	-0.4	0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	2.7	0.0	-1.4	-0.7	1.6	-1.5	1.6
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	-0.7	-0.5	1.0	0.3	0.4	-0.2
Tibia length	0.3	0.8	2.0	-1.4	0.3	0.9	-0.5	0.8	-0.9
Ambulatory time before self-admin	0.1	0.3	0.7	-0.3	-0.7	-0.1	0.8	-0.5	0.6
Ambulatory time after self-admin	0.5	0.7	1.8	-1.0	-1.3	0.1	1.0	-0.7	0.6
Bone: tissue strength	1.3	1.4	2.9	1.7	-0.2	1.2	-0.7	1.2	-1.4
Total heroin consumption	3.0	3.6	18.4	4.3	-0.7	-0.2	0.8	-1.1	0.8
Bone: trabecular number	0.1	0.2	0.5	0.7	-0.3	0.6	0.0	0.3	-0.4
Bone: trabecular spacing	0.8	1.2	2.7	-1.6	0.9	0.8	-0.9	1.0	-1.1
Bone: trabecular thickness	0.7	1.0	1.4	0.7	-1.2	-0.8	1.0	-1.2	1.1
Bone: trabecular tissue density	0.9	1.6	2.2	-1.5	-1.4	-0.7	1.3	-1.4	1.3
Water consumed over 24 hours	2.0	3.8	8.4	-2.6	-0.8	2.9	-0.1	2.0	-1.8
Number of responses in last shaping day	1.4	1.8	7.1	-2.7	-0.7	-1.0	0.6	-1.1	0.9