LOC134483824

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC134483824	0.17	0.09	1.7e-08	0.06	0.07	0.08	0.07	8.9e-07	5.4e-08	5.9e-09	8.2e-08
2	Brain	gene expression	LOC134483824	0.05	0.04	1.0e-03	0.04	0.04	0.02	0.04	7.0e-05	3.1e-04	2.2e-03	1.2e-04
3	Liver	gene expression	LOC134483824	0.19	0.1	1.5e-08	0.07	0.07	0.06	0.07	1.0e-08	1.3e-08	1.5e-07	3.8e-08
4	pVTA	gene expression	LOC134483824	0.05	0.04	2.7e-03	0.02	0.03	0.01	0.02	7.5e-03	3.6e-03	3.7e-02	7.7e-03
5	NAcc	gene expression	LOC134483824	0.06	0.04	8.7e-08	0.05	0.05	0.05	0.05	6.2e-08	1.7e-08	1.8e-08	1.8e-08
6	PL	gene expression	LOC134483824	0.04	0.03	3.3e-03	0.03	0.02	0.01	0.03	3.1e-04	1.3e-03	1.3e-02	7.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	1.1	0.1	1.1	-0.1	0.6	0.5	0.3
Area under the delay curve	0.9	1.0	2.4	-0.2	1.6	-0.9	1.5	0.8	0.5
BMI with tail	0.5	1.7	3.3	0.3	1.1	0.8	1.6	1.8	1.5
BMI without tail	0.2	0.7	1.6	-0.8	1.2	-0.7	1.0	0.5	-0.1
Body weight	0.2	0.8	1.9	0.5	1.4	-0.6	1.2	0.8	0.5
Weight adjusted by age	0.3	0.5	1.0	0.7	0.5	1.0	0.4	0.8	0.7
Bone surface	0.3	0.5	0.9	-0.4	0.9	0.3	0.9	0.9	0.7
Bone volume	0.3	0.5	1.6	-0.4	1.3	0.0	0.8	0.8	0.5
Breakpoint value in progressive ratio session	4.2	5.0	28.8	-5.4	-0.1	0.7	0.1	0.4	0.9
Number of licking bursts	4.9	7.9	14.2	3.1	-1.1	-3.3	-1.6	-3.0	-3.8
Context. condit. distance diff. score	0.5	0.6	3.4	-1.8	-0.0	0.2	-0.2	-0.1	0.0
Locomotion velocity, session 1	2.3	2.5	5.8	1.9	-2.4	0.5	-1.7	-1.3	-0.8
Locomotion distance, session 1	1.5	1.8	4.5	-1.2	-2.1	0.4	-1.6	-1.3	-0.9
Locomotion velocity, session 2	0.8	1.0	2.3	-1.3	-1.0	1.5	-0.2	0.4	0.7
Locomotion distance, session 2	0.7	0.9	2.8	-0.1	-1.7	-0.0	-1.0	-1.0	-0.9
Locomotion velocity, session 3	0.9	1.0	2.9	-1.7	-1.0	1.3	-0.3	0.2	0.5
Locomotion distance, session 3	0.7	0.8	3.1	-1.8	-0.6	-0.2	-0.7	-0.7	-0.5
Stereotopy head waving bouts, day 3	0.8	0.9	4.8	2.2	0.1	-0.6	0.1	-0.1	-0.3
Stereotopy head waving duration, day 3	0.6	0.8	1.6	1.3	0.3	0.7	0.6	0.9	1.1
Locomotion velocity, session 7	1.9	2.1	10.0	-3.2	0.3	1.1	-0.3	0.3	1.1
Locomotion distance, session 7	1.3	1.6	8.8	-3.0	0.7	-0.3	-0.1	-0.1	0.1
Stereotopy head waving bouts, day 7	0.3	0.3	1.0	0.2	-0.5	1.0	0.0	0.5	0.6
Stereotopy head waving duration, day 7	0.8	0.9	3.0	-0.0	-0.9	1.7	-0.0	0.7	1.1
Locomotion velocity, session 8	0.3	0.4	1.0	0.6	-1.0	0.0	-0.6	-0.6	-0.6
Locomotion distance, session 8	0.9	1.2	5.6	-2.4	-0.8	1.0	-0.3	0.1	0.3
Degree of sensitization distance	0.4	0.4	0.6	-0.5	0.7	0.6	0.5	0.7	0.7
Degree of sensitization stereotypy	0.3	0.3	1.0	-0.1	-0.6	1.0	0.1	0.4	0.5
Conditioned locomotion	0.4	0.5	1.0	0.4	-0.7	1.0	0.2	0.6	0.9
Cocaine response after cond. corrected	0.6	0.7	1.1	-1.0	0.1	0.9	0.8	1.0	0.7
Cocaine response after cond. not corrected	2.0	2.4	3.7	-1.9	0.8	1.5	1.3	1.8	1.6
Cocaine response before conditioning	1.3	1.6	3.0	-1.6	1.0	1.3	0.4	1.1	1.7
Saline control response	0.6	0.8	2.7	-0.1	1.0	-1.6	-0.1	-0.7	-0.8
Bone: connectivity density	0.1	0.2	1.1	-1.1	0.3	-0.2	0.1	-0.0	-0.1
Bone: cortical apparent density	5.0	6.8	31.1	-5.6	2.6	-0.8	1.3	0.8	0.3
Bone: cortical area	0.7	1.0	3.7	-1.9	0.8	0.3	0.8	0.8	0.7
Bone: cortical porosity	2.7	2.9	9.2	3.0	-1.4	2.1	-0.2	0.7	1.1
Bone: cortical porosity	2.1	2.3	8.0	2.8	-1.2	1.8	-0.0	0.7	0.9
Bone: cortical thickness	1.3	2.2	6.7	-2.6	1.2	0.9	0.8	1.2	1.4
Bone: cortical thickness	0.2	0.3	1.2	1.1	0.3	0.1	0.4	0.4	0.4
Bone: cortical tissue density	4.9	6.6	29.7	-5.4	2.6	-0.9	1.3	0.8	0.3
Condit. Reinf. active minus inactive responses	1.3	1.4	7.3	-2.7	-0.5	0.9	-0.4	-0.0	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.1	-1.0	-0.1	-0.1	-0.0	-0.1	-0.1
Condit. Reinf. active responses	0.9	1.1	5.6	-2.4	-0.3	0.8	-0.5	-0.0	0.2
Condit. Reinf. inactive responses	0.3	0.4	1.6	-1.3	-0.1	0.7	-0.5	-0.1	0.1
Incentive salience index mean	1.6	1.9	8.4	-2.9	-0.5	1.5	-0.4	0.3	0.7
Condit. Reinf. lever presses	1.3	1.9	7.0	-2.6	-0.3	1.7	-0.2	0.6	1.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.0	-0.2	0.2	-0.3	-0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.5	-1.0	-1.2	0.4	-1.0	-0.7	-0.5
Condit. Reinf. active responses	0.4	0.5	0.7	0.8	0.8	0.1	0.8	0.8	0.6
Condit. Reinf. inactive responses	1.4	1.9	3.7	1.9	1.9	-0.5	1.4	1.0	0.7
Condit. Reinf. lever presses	0.3	0.4	0.6	0.4	0.8	0.3	0.7	0.8	0.6
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.7	0.7	0.0	0.5	0.5	0.4
Conditioned reinforcement - actives	0.8	1.4	4.9	2.2	-0.3	-1.3	0.0	-0.7	-1.2
Conditioned reinforcement - inactives	1.2	1.7	4.1	2.0	1.6	-0.9	1.5	0.8	0.2
Conditioned locomotion	2.5	3.2	17.1	4.1	0.6	-1.1	0.6	0.0	-0.4
Patch foraging indifference point 0 sec	0.6	1.1	3.4	-1.9	1.2	-0.4	0.7	0.5	0.7
Patch foraging indifference point AUC	0.3	0.4	1.5	-1.2	0.5	0.1	0.4	0.4	0.4
Delay disc. indifference point, 0s delay	2.8	3.0	8.0	2.8	1.8	-1.4	1.9	1.0	0.4
Delay disc. indifference point, 16s delay	0.5	0.5	1.1	-0.7	1.0	-0.8	0.8	0.3	0.1
Delay disc. indifference point, 2s delay	0.6	0.6	1.7	0.1	1.3	-0.7	0.9	0.5	0.7
Delay disc. indifference point, 24s delay	0.5	0.5	1.0	1.0	0.9	-0.9	0.7	0.2	-0.2
Delay disc. indifference point, 4s delay	0.3	0.4	0.9	0.2	0.7	-0.2	1.0	0.6	0.4
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.3	0.7	-0.6	0.6	0.2	0.0
Indifference point function ln k	0.5	0.9	4.9	2.2	-0.4	-0.3	-0.2	-0.3	-0.5
Indifference point function log k	0.5	0.9	4.9	2.2	-0.4	-0.3	-0.2	-0.3	-0.5
Patch foraging total patch changes 0 sec	0.5	1.0	3.6	-1.9	1.1	-0.1	0.5	0.5	0.9
Patch foraging total patch changes 12 sec	1.6	2.1	7.3	-2.7	1.6	-0.6	1.2	0.8	0.5
Patch foraging total patch changes 18 sec	1.7	2.6	6.2	-2.5	1.7	0.5	1.3	1.4	1.7
Patch foraging total patch changes 24 sec	0.8	1.4	7.6	-2.8	-0.2	-0.1	-0.5	-0.5	-0.2
Patch foraging total patch changes 6 sec	0.5	0.7	1.7	-0.8	1.3	-0.2	0.9	0.8	0.8
Patch foraging time to switch 0 sec	0.3	0.6	1.4	0.7	-1.1	1.2	-0.5	0.0	0.4
Patch foraging water rate 0 sec	0.3	0.6	2.1	-1.5	0.9	-0.7	0.3	-0.0	-0.1
Patch foraging water rate 12 sec	0.1	0.1	0.5	-0.0	0.7	-0.1	0.5	0.4	0.1
Patch foraging water rate 18 sec	0.6	0.9	1.9	1.4	1.0	-0.1	1.1	1.0	0.3
Patch foraging water rate 24 sec	0.5	0.6	2.0	0.2	1.4	-1.1	0.6	0.1	-0.4
Patch foraging water rate 6 sec	0.3	0.4	1.0	0.4	0.2	-1.0	-0.2	-0.7	-0.9
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.3	-1.1	-0.9	-0.1	-0.9	-0.9	-0.5
Distance traveled before self-admin	0.2	0.3	0.9	0.9	0.7	-0.3	0.6	0.4	-0.0
Distance traveled after self-admin	0.9	1.1	4.1	2.0	1.2	-0.1	0.8	0.7	0.3
Extensor digitorum longus weight	0.1	0.4	1.6	1.2	0.1	-0.3	-0.3	-0.4	-0.5
Bone: elastic displacement	0.8	1.0	3.0	-1.7	1.0	-1.1	0.3	-0.2	-0.7
Bone: elastic work	0.5	0.7	1.8	-0.7	0.9	-1.3	0.3	-0.4	-1.0
Bone: endosteal estimation	0.6	1.3	6.0	2.4	-0.9	-0.2	-0.5	-0.6	-0.7
Bone: endosteal perimeter	0.4	0.8	1.9	-1.1	-1.4	0.1	-0.8	-0.8	-0.6
Epididymis fat weight	0.0	0.2	0.3	0.3	0.4	-0.5	-0.2	-0.4	-0.4
Delta time in closed arm before/after self-admin	2.1	1.9	7.1	2.7	1.0	-1.1	1.4	0.7	-0.1
Delta time in open arm before/after self-admin	0.4	0.4	1.8	-1.3	0.3	0.3	0.1	0.3	0.6
Diff in mean of infusions in LGA sessions	1.7	2.1	4.4	-2.1	0.2	1.7	0.6	1.3	1.8
Delay discount exponential model param	0.7	0.8	1.8	0.3	-1.3	0.8	-1.3	-0.7	-0.4
Extinction: sum of active levers before priming	3.0	3.3	18.9	-4.3	0.5	-0.1	0.4	0.4	0.7
Active lever presses in extinction session 6	1.6	1.6	7.0	-2.6	1.0	-0.1	0.8	0.7	0.8
Bone: final force	0.4	0.7	4.0	-2.0	0.4	-0.2	0.2	0.0	-0.1
Bone: final moment	0.4	0.6	3.4	-1.9	0.2	-0.2	-0.0	-0.1	-0.2
Food consumed during 24 hour testing period	1.3	1.7	5.0	1.3	0.5	-2.2	-0.3	-1.2	-1.5
Glucose	0.4	0.6	1.2	0.3	0.5	0.8	0.7	1.0	1.1
Heart weight	0.2	0.3	0.6	-0.4	0.1	-0.8	-0.4	-0.7	-0.7
Delay discount hyperbolic model param	0.8	0.8	1.7	0.5	-1.3	0.5	-1.3	-0.8	-0.6
Intermittent access intake day 1-15 change	0.3	0.7	1.2	-1.1	1.1	-0.4	0.9	0.7	0.4
Intermittent access intake escalation	0.4	0.8	1.7	-0.5	1.3	-0.5	1.2	0.9	0.4
Intermittent access intake escalation 2	0.4	0.4	1.0	-0.5	1.0	-0.8	0.7	0.5	0.2
Intermitt. access day 1 inactive lever presses	0.3	1.1	6.0	-2.5	0.6	0.0	-0.1	-0.0	0.4
Intermitt. access day 15 inactive lever presses	1.3	2.7	11.2	3.4	1.2	-1.6	0.2	-0.5	-0.8
Intermitt. access escalation Index	1.5	2.2	5.5	2.2	-0.6	2.4	-0.1	0.9	1.1
Intermittent access day 1 total infusions	0.5	0.8	2.3	1.5	0.9	-0.9	0.8	0.3	-0.1
Intermittent access day 15 total infusions	1.9	2.8	5.3	2.3	2.2	-1.1	1.9	1.2	0.6
Intermittent access terminal intake (last 3 days)	2.1	2.8	6.1	1.5	2.5	-1.9	1.9	1.0	0.3
Intermittent access total infusions	3.0	3.6	9.6	3.1	2.2	-1.8	1.8	0.8	0.1
Intermittent access day 1 locomotion	1.3	1.7	5.8	2.4	1.2	-0.9	1.2	0.6	0.1
Intermittent access day 15 total locomotion	0.6	1.1	3.2	1.1	0.9	-1.8	0.5	-0.4	-1.1
Intermittent access total locomotion	1.3	1.6	4.6	2.1	1.2	-1.5	1.0	0.2	-0.3
Intermittent access standard deviation	1.0	2.2	4.3	1.8	1.7	-2.1	1.4	0.4	-0.0
Left kidney weight	0.2	0.7	2.8	-1.7	0.4	0.8	0.3	0.6	0.7
Right kidney weight	0.3	1.6	2.4	-1.5	1.1	0.7	1.1	1.3	1.5
Cocaine induced anxiety	0.5	0.6	2.1	-1.5	-0.7	-0.3	-0.7	-0.7	-0.3
Post-drug Anxiety	0.6	0.6	3.3	-1.8	-0.0	0.0	0.2	0.2	0.4
Baseline Anxiety	0.1	0.1	0.5	-0.7	-0.2	-0.1	-0.2	-0.3	-0.3
Tail length	0.5	2.1	3.3	-1.7	0.1	-1.8	-1.0	-1.7	-1.7
Length with tail	0.3	1.3	3.0	-1.0	0.5	-1.7	-0.7	-1.3	-1.3
Length without tail	0.1	0.4	2.3	1.5	-0.1	0.2	-0.1	0.0	0.2
Times rat made contact with spout	6.8	7.8	15.1	3.9	0.4	-3.8	-0.8	-2.4	-3.2
Lifetime Intake	2.7	3.3	11.4	3.4	1.9	-1.0	1.7	1.0	0.5
Liver weight, left	0.9	1.5	3.8	-1.9	-1.1	-0.1	-1.3	-1.2	-0.8
Liver weight, right	2.5	4.4	10.6	3.2	-1.5	-1.0	-1.9	-2.1	-2.0
Locomotor activity	0.2	0.3	1.4	1.2	-0.3	0.4	-0.0	0.1	0.1
Locomotor testing distance	0.2	0.3	0.8	-0.4	-0.9	0.4	-0.7	-0.5	-0.4
Locomotor testing rearing	0.8	1.7	7.3	-2.7	-0.1	-0.7	-0.8	-1.0	-0.8
Locomotion in novel chamber	0.0	0.0	0.2	-0.4	-0.1	0.1	-0.3	-0.1	0.2
Locomotion in novel chamber post-restriction	0.4	0.6	1.3	0.7	-0.3	-1.0	-0.4	-0.8	-1.1
Fecal boli incidents, locomotor time 1	0.3	0.4	1.7	-1.3	-0.5	0.2	-0.3	-0.3	-0.3
Change in fecal boli incidents, locomotor task	1.0	1.0	1.6	1.2	1.3	0.2	0.9	1.0	1.0
Time >=10cm from walls, locomotor time 1	1.4	1.4	2.3	-0.7	1.3	0.4	1.5	1.5	1.4
Bouts of movement, locomotor time 1	0.5	0.6	1.6	-0.4	0.3	1.3	-0.2	0.4	1.1
Total resting periods, locomotor time 1	0.4	0.4	1.4	-0.4	0.2	1.2	-0.2	0.4	0.9
Rest time, locomotor task time 1	0.3	0.4	1.0	-1.0	0.1	0.8	0.1	0.4	0.6
Distance moved, locomotor task time 1	0.2	0.3	0.6	-0.5	0.4	0.0	0.8	0.7	0.7
Vertical activity count, locomotor time 1	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.3	0.1	-0.2
Time >=10cm from walls, locomotor time 2	1.2	1.7	3.2	-0.5	1.5	0.3	1.8	1.7	1.4
Bouts of movement, locomotor time 2	0.2	0.3	0.7	0.1	0.1	0.8	0.4	0.8	0.8
Total resting periods, locomotor time 2	0.1	0.2	0.4	0.2	-0.0	0.7	0.3	0.6	0.6
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.6	0.0	0.4	0.1	0.2	0.3
Distance moved, locomotor task time 2	0.6	0.7	1.2	-0.9	0.3	0.8	0.7	1.0	1.1
Vertical activity count, locomotor time 2	0.7	0.9	2.4	-0.5	0.7	-0.0	1.5	1.3	0.8
Light reinforcement 1	0.2	0.6	2.3	-1.5	-0.1	0.8	-0.2	0.2	0.6
Light reinforcement 2	0.5	0.8	2.2	1.5	0.9	-1.1	0.6	-0.0	-0.6
Bone: marrow area	0.6	1.2	5.4	2.3	-0.9	-0.2	-0.5	-0.6	-0.7
Bone: maximum diameter	0.4	0.8	1.6	1.3	-0.4	-1.0	-0.3	-0.8	-1.0
Bone: maximum force	0.2	0.4	1.7	-1.3	0.1	-0.5	-0.2	-0.4	-0.6
Bone: maximum moment	0.2	0.4	1.3	-1.1	-0.1	-0.5	-0.3	-0.5	-0.7
Mean time between licks in bursts	0.5	1.2	2.2	-1.0	0.1	1.5	0.7	1.2	1.4
Mean num. licks in bursts	1.2	1.9	3.2	-1.2	1.4	0.9	1.2	1.5	1.8
Cd content in liver	2.4	2.7	9.9	3.1	-0.1	-1.7	-0.4	-1.1	-1.4
Co content in liver	4.4	5.1	15.7	4.0	1.3	0.8	2.2	2.2	1.8
Cu content in liver	1.0	1.2	2.6	1.2	1.6	-0.2	1.2	1.0	1.0
Fe content in liver	1.3	1.6	8.9	-3.0	0.4	-0.3	-0.4	-0.5	-0.4
K content in liver	0.6	0.6	1.7	-0.5	0.0	1.2	-0.2	0.4	1.3
Mg content in liver	0.6	0.7	1.3	1.1	0.8	0.2	0.8	0.8	0.9
Mn content in liver	0.5	0.6	1.5	0.9	1.2	-0.3	0.8	0.6	0.6
Na content in liver	0.6	0.6	1.1	-0.8	-0.8	-0.1	-1.1	-1.0	-0.5
Rb content in liver	0.7	0.8	3.2	0.3	1.8	-0.4	0.8	0.6	0.5
Se content in liver	0.1	0.1	0.5	0.7	-0.1	-0.2	0.1	-0.0	0.0
Sr content in liver	1.5	1.3	7.0	2.6	-0.7	-0.2	-0.3	-0.4	-0.4
Zn content in liver	2.9	3.2	10.4	3.2	1.6	-0.1	1.6	1.4	1.2
Bone: minimum diameter	1.2	2.1	10.4	-3.2	-0.1	1.1	0.2	0.6	0.9
Time in familiar zone, hab. session 1	0.4	0.4	1.7	1.3	0.1	-0.2	0.5	0.3	0.1
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.7	-0.2	-0.4	-0.6	-0.7	-0.6
Total zone transitions, hab. session 1	1.6	2.2	6.5	2.5	0.1	-2.0	0.2	-0.8	-1.5
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.8	-0.5	-0.6	-0.4	-0.7	-0.7
Locomotion velocity, hab. session 1	0.2	0.3	0.8	0.0	-0.9	0.0	-0.8	-0.7	-0.4
Time in familiar zone, hab. session 2	0.4	0.4	2.2	-1.5	-0.1	0.3	-0.0	0.1	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.9	1.0	-0.1	-0.2	-0.3	-0.4	-0.3
Total zone transitions, hab. session 2	0.3	0.4	1.1	-1.1	-0.5	-0.4	-0.2	-0.4	-0.6
Total locomotion distance, hab. session 2	0.8	1.1	5.1	-2.3	-0.6	0.8	-0.4	-0.1	0.3
Locomotion velocity, hab. session 2	0.6	0.8	4.4	-2.1	-0.4	0.6	-0.3	0.0	0.2
Novel to familiar place preference ratio	2.7	3.0	5.5	-0.6	0.8	2.3	1.2	2.1	2.3
Novelty place preference	2.6	2.8	6.0	-0.6	0.6	2.5	0.9	2.0	2.3
Time in novel zone, NPP test	1.7	1.8	4.6	-0.5	0.3	2.1	0.6	1.5	1.8
Total zone transitions, NPP test	0.2	0.4	0.7	0.4	-0.8	-0.3	-0.5	-0.6	-0.7
Total locomotion distance, NPP test	0.8	1.1	3.2	-1.8	-1.1	1.0	-1.0	-0.4	0.1
Locomotion velocity, NPP test	0.8	1.1	3.9	-2.0	-0.7	1.2	-0.6	0.0	0.5
Intraocular pressure	1.0	1.4	4.1	-0.9	2.0	-0.4	1.3	1.1	0.8
Delta distance traveled before/after self-admin	1.9	2.0	3.9	2.0	1.4	0.8	1.3	1.5	1.4
Delta ambulatory time before/after self-admin	0.5	0.6	1.7	1.3	1.0	-0.0	0.5	0.5	0.5
Parametrial fat weight	1.7	3.9	20.8	-4.6	-0.1	-0.4	-1.1	-1.1	-0.5
Pavlov. Cond. lever latency	0.8	1.0	3.2	0.7	0.2	-1.8	0.2	-0.6	-1.3
Pavlov. Cond. magazine entry latency	1.0	1.2	2.9	-1.0	-1.3	0.6	-1.7	-1.2	-0.3
Pavlov. Cond. change in total contacts	0.4	0.4	1.1	-0.9	-0.1	1.1	-0.6	0.0	0.6
Pavlov. Cond. index score	0.7	0.9	2.2	-0.8	-1.0	1.5	-1.1	-0.3	0.6
Pavlov. Cond. latency score	0.8	1.1	2.8	-1.0	-0.9	1.7	-1.0	-0.1	0.8
Pavlov. Cond. lever contacts	0.5	0.6	2.0	-0.9	-0.3	1.4	-0.5	0.2	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-0.2	0.9	-0.4	1.1	0.7	0.3
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.4	-0.8	0.8	0.3	1.2	1.1	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.9	-0.6	-0.7	1.4	-0.9	-0.1	0.8
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.5	-0.7	0.7	-0.9	-0.5	0.1
Pavlov. Cond. lever latency	1.6	2.2	3.8	0.5	-1.7	-1.0	-1.7	-1.9	-1.7
Pavlov. Cond. magazine entry latency	1.4	1.7	2.7	-1.6	1.1	0.8	1.3	1.5	1.4
Pavlov. Cond. change in total contacts	2.4	3.9	7.7	1.7	2.8	-0.1	2.5	2.2	1.4
Pavlov. Cond. index score	1.4	1.9	3.1	-0.6	1.8	0.4	1.7	1.7	1.4
Pavlov. Cond. latency score	1.3	1.7	2.7	-0.9	1.6	0.5	1.5	1.6	1.3
Pavlov. Cond. lever contacts	1.3	1.8	2.9	-0.7	1.6	0.6	1.6	1.7	1.3
Pavlov. Cond. magazine entry number	0.9	1.1	1.8	1.3	-0.9	-0.6	-1.1	-1.2	-1.0
Pavlov. Cond. intertrial magazine entries	1.0	1.4	3.1	-0.6	0.6	1.7	0.5	1.3	1.8
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.5	-0.7	1.6	0.5	1.5	1.6	1.4
Pavlov. Cond. response bias	1.9	2.5	4.3	-0.6	1.7	1.0	1.8	2.1	1.8
Time in closed arm before self-admin	2.1	2.7	11.4	-3.4	-1.1	0.5	-1.5	-1.1	-0.5
Time in closed arm after self-admin	0.3	0.3	0.9	-0.2	-0.3	-0.6	-0.1	-0.4	-1.0
Time in open arm before self-admin	0.9	1.0	3.0	1.7	1.0	-0.9	0.9	0.4	-0.3
Time in open arm after self-admin	0.4	0.5	1.2	-0.4	1.1	-0.5	0.9	0.6	0.5
Bone: periosteal estimation	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2	-0.2
Bone: periosteal perimeter	0.7	1.1	6.8	-2.6	0.1	-0.0	0.0	0.0	0.0
Bone: post-yield work	1.0	1.5	3.1	-0.4	-1.2	-1.1	-1.1	-1.5	-1.8
Progressive ratio test 1 active lever presses	2.8	3.4	16.0	4.0	1.3	-1.4	0.8	0.1	-0.5
Progressive ratio test 1 breakpoint	3.0	3.7	17.8	4.2	1.2	-1.4	0.7	0.0	-0.6
Progressive ratio test 1 inactive lever presses	1.2	1.7	8.4	2.9	1.0	-1.0	0.2	-0.2	-0.2
Progressive ratio test 2 active lever presses	2.0	2.3	4.7	-0.9	2.2	-2.2	1.9	0.6	0.2
Progressive ratio test 2 breakpoint	1.9	2.2	4.9	-0.7	2.1	-2.2	1.8	0.5	0.1
Progressive ratio test 2 inactive lever presses	1.6	2.6	7.5	0.4	2.7	-1.5	2.1	1.1	0.6
Incentive Sensitization - Responses	2.2	3.2	7.9	-2.2	2.0	-2.8	1.5	0.0	-0.5
Incentive Sensitization - Breakpoint	2.4	3.1	7.9	-2.2	1.9	-2.8	1.5	-0.0	-0.5
Sum of active levers in priming session hrs 5-6	1.2	1.2	6.0	-2.4	0.5	0.0	0.3	0.4	0.7
Progressive ratio	1.8	2.8	9.9	-3.1	-1.4	0.3	-1.7	-1.3	-0.7
Food seeking constrained by brief footshock	0.6	0.8	4.0	2.0	0.4	-0.5	0.4	0.0	-0.3
Seeking ratio, punishment vs. effort	1.8	2.6	6.1	2.5	1.7	-0.5	1.9	1.5	0.8
Retroperitoneal fat weight	0.1	0.3	0.8	-0.9	0.8	-0.5	0.2	-0.0	0.1
Reaction time number correct	1.5	2.8	9.4	3.1	1.6	-0.7	1.7	1.2	0.3
Reaction time mean minus median	0.2	0.5	0.9	-0.7	-0.2	-0.9	-0.3	-0.7	-1.0
Reaction time mean minus median AUC	0.2	0.6	1.4	-0.8	0.2	-1.2	0.1	-0.5	-1.1
Reaction time num false alarms	2.1	2.9	16.5	-4.1	0.2	0.4	-0.4	-0.1	0.7
Reaction time num false alarms AUC	1.5	2.4	13.6	-3.7	0.3	0.1	-0.2	-0.0	0.6
Reaction time trials correct on left	1.5	2.8	9.4	3.1	1.6	-0.7	1.7	1.2	0.3
Reaction time trials on left	1.4	2.7	8.4	2.9	1.6	-0.7	1.7	1.2	0.3
Reaction time mean	1.7	2.7	3.9	-1.1	-1.9	-0.9	-1.7	-1.9	-2.0
Reaction time mean AUC	1.2	2.0	3.1	-0.8	-1.6	-0.9	-1.4	-1.7	-1.7
Median of all reaction times	1.7	2.4	3.9	-0.8	-2.0	-0.7	-1.7	-1.9	-1.8
Reaction time omissions	1.7	2.4	14.0	-3.7	-0.6	0.2	-0.3	-0.2	-0.3
Reaction time false alarm rate	3.0	4.1	22.2	-4.7	-0.6	0.5	-1.1	-0.7	0.3
Reaction time premature initiation rate	3.4	4.7	10.1	-1.2	-3.2	0.5	-3.0	-2.4	-1.4
Reaction time premature initiations	0.9	1.7	3.9	-0.1	-2.0	0.3	-1.7	-1.4	-1.0
Std. dev. reaction times	1.2	2.2	5.4	-2.3	-1.3	-0.8	-1.1	-1.4	-1.5
Reaction time trials completed	1.4	2.7	8.4	2.9	1.6	-0.7	1.7	1.2	0.3
Reaction time trials AUC	1.5	2.9	8.2	2.9	1.8	-0.7	1.9	1.3	0.4
Run reversals in cocaine runway, females	1.7	1.7	2.7	1.6	1.1	0.7	1.5	1.5	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.7	-0.8	-0.1	-0.3	0.3	0.0	-0.3
Latency to leave start box in cocaine runway	3.2	3.6	5.8	-1.7	1.1	1.9	1.8	2.4	2.3
Latency to leave start box in cocaine runway, F	3.0	3.4	4.9	-2.1	1.5	1.2	1.8	2.2	2.0
Latency to leave start box in cocaine runway, M	0.7	0.6	1.2	0.2	0.1	0.9	0.8	1.1	1.0
Std. dev. time between licks in bursts	0.5	0.6	1.3	0.1	-0.8	-0.7	-0.6	-0.9	-1.2
Total sessions with >9 infusions	2.9	3.6	16.9	4.1	1.4	-0.4	1.2	0.9	0.4
Short access day 1 total inactive lever presses	1.6	2.1	8.9	3.0	0.7	-1.4	0.4	-0.4	-0.9
Short access day 10 total inactive lever presses	0.7	1.7	2.9	1.2	-0.9	-1.0	-1.4	-1.7	-1.5
Short access day 1 total infusions	5.8	7.7	41.7	6.5	1.2	-0.0	1.3	1.1	0.5
Short access day 10 total infusions	2.6	3.3	15.7	4.0	1.4	-1.0	0.9	0.4	0.2
Short access total infusions	3.5	4.4	22.5	4.7	1.2	0.1	1.1	1.0	0.7
Short access day 1 locomotion	3.9	4.9	29.1	5.4	0.4	-0.3	0.2	0.0	-0.1
Short access day 10 total locomotion	0.9	1.7	9.6	3.1	0.2	-0.1	0.5	0.4	0.2
Short access total locomotion	1.3	1.6	8.3	2.9	0.6	0.1	0.6	0.5	0.4
One hour access (0.3 mA shock)	0.2	0.2	0.5	0.2	0.7	-0.7	0.6	0.2	0.1
Compulsive drug intake	2.5	3.0	15.0	3.9	-1.3	0.8	-0.8	-0.4	-0.3
One hour access (shock baseline)	1.5	2.3	8.9	-3.0	1.5	-0.8	1.1	0.6	0.6
Social response proportion	0.7	0.7	4.0	2.0	0.5	-0.4	0.2	0.0	-0.0
Social responses	0.2	0.3	0.7	0.7	0.8	0.2	0.3	0.4	0.5
Social time	0.4	0.5	1.4	-0.0	0.8	-1.2	-0.0	-0.6	-0.7
Soleus weight	0.1	0.3	0.7	-0.6	-0.5	-0.1	-0.3	-0.3	-0.8
Bone: stiffness	0.2	0.4	1.1	-0.1	-1.1	0.2	-0.7	-0.6	-0.4
Tibialis anterior weight	1.0	3.5	8.4	2.3	1.5	-2.9	0.5	-0.8	-2.1
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.8	-0.3	-1.0	-0.3	-1.3	-1.2	-0.7
Time to tail flick, vehicle, after self-admin	2.0	2.6	5.1	2.3	1.7	0.3	1.7	1.7	1.4
Time to tail flick, test, before self-admin	0.4	0.5	0.9	-0.5	-0.8	0.9	-0.9	-0.4	0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.6	0.8	0.1	-0.5	-0.4	-0.6	-0.5
Delta time to tail flick, vehicle, before/after SA	1.8	1.7	2.9	0.0	1.4	0.7	1.6	1.7	1.5
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	0.7	0.5	-1.0	0.3	-0.1	-0.4
Tibia length	0.3	0.8	1.8	1.3	-0.3	-0.9	-0.5	-0.9	-0.8
Ambulatory time before self-admin	0.2	0.4	0.7	0.3	0.7	0.1	0.8	0.8	0.5
Ambulatory time after self-admin	0.6	0.8	1.8	0.8	1.3	-0.1	1.0	0.9	0.7
Bone: tissue strength	1.3	1.3	3.2	-1.8	0.2	-1.2	-0.7	-1.1	-1.2
Total heroin consumption	2.8	3.3	17.1	-4.1	0.7	0.2	0.8	0.8	1.1
Bone: trabecular number	0.1	0.2	0.5	-0.7	0.3	-0.6	0.0	-0.2	-0.3
Bone: trabecular spacing	0.9	1.2	2.3	1.5	-0.9	-0.8	-0.9	-1.2	-1.0
Bone: trabecular thickness	0.9	1.1	1.6	-0.7	1.2	0.8	1.0	1.3	1.2
Bone: trabecular tissue density	1.1	1.7	2.2	1.4	1.4	0.7	1.3	1.5	1.4
Water consumed over 24 hours	2.6	3.4	8.4	2.4	0.8	-2.9	-0.1	-1.4	-2.0
Number of responses in last shaping day	1.6	1.8	6.3	2.5	0.9	1.0	0.6	1.0	1.1