Hub : Genes

Zyg11b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Zyg11b 0.11 0.08 4.9e-04 0.04 0.03 0.05 0.05 2.2e-03 1.0e-02 1.1e-03 1.6e-03
2 Adipose gene expression Zyg11b 0.04 0.03 3.4e-03 0.03 0.01 0.02 0.03 1.3e-04 4.0e-02 1.7e-03 3.7e-04
3 IC gene expression Zyg11b 0.12 0.08 1.3e-04 0.07 0.1 0.06 0.08 9.8e-04 7.8e-05 1.4e-03 3.8e-04
4 Brain gene expression Zyg11b 0.1 0.06 4.1e-10 0.09 0.11 0.1 0.1 9.0e-09 4.2e-10 1.6e-09 5.9e-10
5 pVTA gene expression Zyg11b 0.06 0.05 1.3e-05 0.04 0.05 0.05 0.05 2.5e-04 4.3e-05 7.3e-05 1.2e-04
6 NAcc gene expression Zyg11b 0.06 0.04 7.3e-09 0.06 0.04 0.05 0.05 5.1e-09 4.1e-06 1.2e-07 9.8e-08
7 PL gene expression Zyg11b 0.05 0.04 4.3e-06 0.05 0.05 0.04 0.04 8.3e-06 6.7e-06 2.0e-05 2.3e-05
8 IL gene expression Zyg11b 0.2 0.13 3.6e-03 0.05 0.05 0.05 0.04 2.1e-02 2.9e-02 2.5e-02 3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.61.11.70.6-1.31.01.01.01.11.01.1
Area under the delay curve0.10.10.5-0.70.10.10.10.0-0.10.0-0.1
BMI with tail1.34.35.8-0.11.8-2.4-2.4-2.4-2.1-2.3-2.2
BMI without tail0.72.02.6-0.31.3-1.6-1.6-1.6-1.5-1.6-1.5
Body weight0.73.14.1-0.11.5-2.0-2.0-2.0-1.8-2.0-1.9
Weight adjusted by age0.20.30.60.80.7-0.6-0.5-0.5-0.4-0.5-0.4
Bone surface0.20.30.8-0.1-0.90.60.60.60.50.60.5
Bone volume0.00.10.20.1-0.50.20.20.20.20.20.2
Breakpoint value in progressive ratio session0.00.10.10.3-0.30.10.20.20.20.20.4
Number of licking bursts0.10.20.70.8-0.3-0.4-0.4-0.3-0.2-0.30.1
Context. condit. distance diff. score0.60.71.51.2-0.50.70.80.80.80.81.1
Locomotion velocity, session 13.94.25.21.7-2.31.92.02.02.22.02.3
Locomotion distance, session 10.20.20.70.8-0.50.20.30.30.40.30.6
Locomotion velocity, session 23.84.45.61.9-2.31.92.02.02.22.12.4
Locomotion distance, session 20.81.11.6-1.20.7-0.9-1.0-1.0-1.3-1.0-1.0
Locomotion velocity, session 30.91.11.70.4-1.31.01.11.10.91.11.2
Locomotion distance, session 30.30.30.8-0.90.5-0.3-0.3-0.4-0.6-0.4-0.6
Stereotopy head waving bouts, day 30.20.20.80.5-0.90.10.10.20.30.20.4
Stereotopy head waving duration, day 30.91.02.11.4-1.50.60.60.71.00.81.1
Locomotion velocity, session 70.10.10.6-0.50.80.20.20.1-0.30.1-0.1
Locomotion distance, session 70.60.72.4-1.61.3-0.0-0.1-0.2-0.9-0.3-0.7
Stereotopy head waving bouts, day 72.12.33.21.0-1.81.51.51.51.51.51.7
Stereotopy head waving duration, day 72.22.73.61.2-1.91.61.61.61.61.61.8
Locomotion velocity, session 81.72.12.51.2-1.11.51.51.51.51.51.6
Locomotion distance, session 80.00.00.10.30.20.20.20.2-0.00.20.3
Degree of sensitization distance0.20.20.8-0.30.9-0.2-0.2-0.2-0.5-0.3-0.3
Degree of sensitization stereotypy1.11.21.60.6-1.11.11.11.21.01.21.3
Conditioned locomotion0.20.32.01.40.0-0.2-0.2-0.10.2-0.00.4
Cocaine response after cond. corrected2.63.13.8-1.91.4-1.7-1.7-1.8-2.0-1.8-1.9
Cocaine response after cond. not corrected3.03.54.1-1.51.5-1.9-1.9-2.0-2.0-2.0-2.0
Cocaine response before conditioning0.10.10.50.70.1-0.2-0.2-0.10.1-0.1-0.0
Saline control response0.50.72.2-1.51.4-0.1-0.2-0.3-0.9-0.3-0.8
Bone: connectivity density1.01.52.50.0-1.61.31.31.31.11.31.1
Bone: cortical apparent density2.23.03.81.4-1.71.71.81.81.91.81.9
Bone: cortical area1.42.23.4-0.71.8-1.5-1.5-1.5-1.5-1.5-1.6
Bone: cortical porosity0.91.04.32.1-1.00.30.40.51.00.50.9
Bone: cortical porosity1.21.34.12.0-1.10.70.70.81.30.91.2
Bone: cortical thickness2.54.25.8-0.32.4-2.2-2.2-2.2-2.0-2.2-2.0
Bone: cortical thickness1.61.92.70.51.6-1.6-1.5-1.5-1.2-1.5-1.2
Bone: cortical tissue density2.53.54.31.5-1.81.81.81.92.01.92.1
Condit. Reinf. active minus inactive responses0.50.50.7-0.30.4-0.8-0.8-0.8-0.8-0.8-0.7
Condit. Reinf. active-inactive response ratio0.70.70.9-0.30.7-0.9-0.9-0.9-0.9-0.9-0.8
Condit. Reinf. active responses1.01.21.7-0.40.7-1.3-1.3-1.3-1.2-1.3-1.1
Condit. Reinf. inactive responses0.10.20.2-0.40.4-0.3-0.3-0.4-0.4-0.4-0.4
Incentive salience index mean1.41.82.5-0.40.8-1.6-1.6-1.5-1.5-1.5-1.3
Condit. Reinf. lever presses1.42.02.8-0.40.9-1.7-1.7-1.6-1.6-1.6-1.3
Condit. Reinf. active minus inactive responses0.81.13.3-1.11.8-0.6-0.7-0.7-1.1-0.8-1.0
Condit. Reinf. active-inactive response ratio0.30.31.2-0.81.1-0.2-0.2-0.2-0.5-0.3-0.5
Condit. Reinf. active responses0.50.61.8-0.61.3-0.6-0.6-0.7-0.8-0.7-0.8
Condit. Reinf. inactive responses0.20.30.50.10.4-0.7-0.7-0.7-0.5-0.7-0.5
Condit. Reinf. lever presses0.30.42.4-1.6-0.10.40.30.2-0.30.2-0.3
Condit. Reinf. lever reinforcers received0.40.61.4-0.91.2-0.5-0.6-0.6-0.8-0.6-0.8
Conditioned reinforcement - actives2.64.49.0-2.03.0-1.8-1.9-1.9-2.2-2.0-1.7
Conditioned reinforcement - inactives0.10.10.2-0.10.5-0.3-0.3-0.2-0.3-0.3-0.1
Conditioned locomotion1.01.32.6-1.01.6-1.0-1.1-1.1-1.3-1.1-0.8
Patch foraging indifference point 0 sec0.40.70.8-0.50.8-0.9-0.9-0.9-0.8-0.9-0.9
Patch foraging indifference point AUC0.20.30.7-0.0-0.80.60.60.60.50.60.6
Delay disc. indifference point, 0s delay0.20.20.7-0.8-0.30.50.50.40.30.40.3
Delay disc. indifference point, 16s delay1.11.21.4-0.81.0-1.2-1.2-1.2-1.2-1.2-1.2
Delay disc. indifference point, 2s delay0.00.00.1-0.10.10.30.20.20.20.20.2
Delay disc. indifference point, 24s delay0.10.10.20.00.20.40.40.40.30.40.3
Delay disc. indifference point, 4s delay0.10.10.2-0.40.3-0.1-0.1-0.2-0.2-0.2-0.2
Delay disc. indifference point, 8s delay0.00.10.4-0.60.1-0.0-0.0-0.1-0.2-0.1-0.2
Indifference point function ln k0.30.60.7-0.20.7-0.9-0.9-0.9-0.8-0.8-0.8
Indifference point function log k0.30.60.7-0.20.7-0.9-0.9-0.9-0.8-0.8-0.8
Patch foraging total patch changes 0 sec0.30.50.7-0.40.5-0.8-0.8-0.8-0.7-0.8-0.8
Patch foraging total patch changes 12 sec0.91.21.40.3-0.91.21.21.21.11.21.2
Patch foraging total patch changes 18 sec0.20.30.4-0.5-0.3-0.6-0.6-0.6-0.6-0.6-0.5
Patch foraging total patch changes 24 sec0.71.11.6-0.30.7-1.3-1.2-1.2-1.0-1.2-1.2
Patch foraging total patch changes 6 sec0.20.41.1-1.10.2-0.4-0.5-0.5-0.6-0.5-0.7
Patch foraging time to switch 0 sec1.02.02.60.9-1.41.41.41.51.61.51.6
Patch foraging water rate 0 sec1.32.73.5-0.51.2-1.9-1.9-1.9-1.7-1.8-1.8
Patch foraging water rate 12 sec2.04.16.1-1.21.4-2.2-2.2-2.2-2.1-2.2-2.5
Patch foraging water rate 18 sec0.10.10.50.7-0.20.00.00.10.30.10.1
Patch foraging water rate 24 sec0.10.10.50.7-0.2-0.2-0.2-0.20.0-0.10.1
Patch foraging water rate 6 sec1.11.62.1-0.50.8-1.4-1.4-1.4-1.3-1.4-1.5
Seeking ratio, delayed vs. immediate footshock2.63.13.8-1.11.9-1.8-1.8-1.9-2.0-1.9-1.8
Distance traveled before self-admin0.10.10.40.6-0.1-0.4-0.4-0.4-0.0-0.3-0.2
Distance traveled after self-admin0.70.91.30.20.7-1.1-1.1-1.1-0.8-1.1-1.0
Extensor digitorum longus weight0.83.14.70.51.3-2.2-2.1-2.0-1.7-2.0-1.5
Bone: elastic displacement0.20.20.90.9-0.6-0.1-0.1-0.00.3-0.00.2
Bone: elastic work0.10.10.20.30.2-0.4-0.4-0.4-0.2-0.4-0.3
Bone: endosteal estimation0.10.20.7-0.6-0.90.40.40.30.40.30.1
Bone: endosteal perimeter0.20.41.7-1.3-0.80.60.60.50.20.50.1
Epididymis fat weight0.00.10.4-0.70.00.40.40.40.20.30.1
Delta time in closed arm before/after self-admin0.00.00.1-0.30.2-0.0-0.0-0.0-0.2-0.0-0.1
Delta time in open arm before/after self-admin0.10.10.3-0.5-0.2-0.3-0.3-0.3-0.4-0.3-0.2
Diff in mean of infusions in LGA sessions0.20.20.6-0.70.8-0.2-0.2-0.2-0.3-0.3-0.4
Delay discount exponential model param0.10.10.50.7-0.2-0.1-0.0-0.00.10.00.1
Extinction: sum of active levers before priming0.20.21.31.1-0.3-0.3-0.2-0.20.0-0.10.1
Active lever presses in extinction session 62.02.02.3-1.01.5-1.4-1.4-1.5-1.3-1.5-1.5
Bone: final force0.00.00.2-0.5-0.00.10.10.1-0.00.0-0.1
Bone: final moment0.10.10.4-0.60.2-0.1-0.1-0.1-0.2-0.1-0.4
Food consumed during 24 hour testing period1.21.64.7-2.21.3-0.6-0.7-0.8-1.4-0.9-1.3
Glucose0.30.40.8-0.90.7-0.4-0.5-0.5-0.7-0.5-0.7
Heart weight1.11.72.60.80.9-1.6-1.6-1.5-1.0-1.5-1.1
Delay discount hyperbolic model param0.00.00.30.5-0.2-0.1-0.1-0.10.0-0.10.0
Intermittent access intake day 1-15 change0.71.55.0-0.72.2-0.9-1.0-1.0-1.0-1.0-1.1
Intermittent access intake escalation0.61.34.6-0.32.1-1.0-1.0-1.0-1.0-1.0-1.1
Intermittent access intake escalation 20.60.63.7-0.11.9-0.4-0.5-0.5-0.5-0.5-0.5
Intermitt. access day 1 inactive lever presses0.62.34.1-0.72.0-1.5-1.5-1.5-1.5-1.5-1.4
Intermitt. access day 15 inactive lever presses0.30.60.80.20.6-0.9-0.9-0.8-0.8-0.8-0.6
Intermitt. access escalation Index0.10.20.80.8-0.90.10.10.10.40.2-0.0
Intermittent access day 1 total infusions0.10.20.90.90.30.20.20.30.30.30.6
Intermittent access day 15 total infusions0.40.62.80.51.7-0.6-0.6-0.6-0.5-0.6-0.4
Intermittent access terminal intake (last 3 days)0.30.42.70.61.6-0.2-0.2-0.2-0.2-0.2-0.0
Intermittent access total infusions0.20.20.90.91.0-0.00.00.00.10.10.3
Intermittent access day 1 locomotion0.10.10.30.60.10.10.10.10.20.10.4
Intermittent access day 15 total locomotion0.30.52.2-0.71.5-0.4-0.5-0.5-0.7-0.5-0.3
Intermittent access total locomotion0.10.10.50.70.6-0.1-0.1-0.0-0.0-0.00.2
Intermittent access standard deviation1.63.34.7-0.82.2-1.9-1.9-1.9-1.9-1.9-1.9
Left kidney weight5.224.228.6-1.74.7-5.3-5.3-5.3-5.2-5.3-5.2
Right kidney weight3.013.817.1-0.93.4-4.1-4.1-4.1-3.8-4.1-4.0
Cocaine induced anxiety0.40.61.01.00.3-0.9-0.9-0.8-0.6-0.7-0.6
Post-drug Anxiety0.91.02.31.50.4-1.1-1.0-1.0-0.8-0.9-0.8
Baseline Anxiety0.10.10.30.10.5-0.4-0.4-0.4-0.4-0.4-0.4
Tail length0.00.00.10.2-0.20.10.10.10.10.10.2
Length with tail0.20.80.9-0.50.9-0.9-0.9-0.9-1.0-0.9-0.9
Length without tail1.75.46.3-1.62.4-2.3-2.3-2.4-2.5-2.4-2.5
Times rat made contact with spout0.81.02.8-1.70.3-0.6-0.7-0.7-1.3-0.8-1.0
Lifetime Intake0.10.21.10.41.00.00.00.10.10.10.2
Liver weight, left0.10.10.4-0.6-0.00.40.40.30.10.30.2
Liver weight, right0.10.20.4-0.6-0.10.50.50.40.10.40.2
Locomotor activity0.30.52.4-1.60.6-0.2-0.3-0.3-0.7-0.4-0.7
Locomotor testing distance0.71.23.7-1.91.0-0.6-0.7-0.8-1.2-0.9-1.2
Locomotor testing rearing0.71.44.6-2.11.7-0.5-0.5-0.6-1.1-0.7-1.1
Locomotion in novel chamber3.74.75.6-2.21.5-2.1-2.2-2.2-2.3-2.3-2.4
Locomotion in novel chamber post-restriction0.10.20.91.0-0.4-0.5-0.4-0.3-0.1-0.3-0.0
Fecal boli incidents, locomotor time 10.10.20.7-0.80.8-0.1-0.2-0.2-0.3-0.2-0.4
Change in fecal boli incidents, locomotor task0.30.30.4-0.0-0.50.60.60.60.50.60.6
Time >=10cm from walls, locomotor time 11.71.83.41.4-1.81.11.21.21.51.31.3
Bouts of movement, locomotor time 10.80.92.5-0.6-1.61.01.00.90.70.90.8
Total resting periods, locomotor time 10.60.72.1-0.3-1.40.80.80.80.60.80.7
Rest time, locomotor task time 10.10.10.4-0.6-0.00.30.30.20.00.20.0
Distance moved, locomotor task time 10.30.52.11.5-0.30.30.40.50.70.50.7
Vertical activity count, locomotor time 10.10.30.90.20.9-0.6-0.6-0.6-0.5-0.6-0.4
Time >=10cm from walls, locomotor time 20.10.10.70.8-0.0-0.1-0.0-0.00.30.00.0
Bouts of movement, locomotor time 20.50.92.00.9-1.40.70.80.80.90.80.9
Total resting periods, locomotor time 20.50.82.30.6-1.50.70.70.80.80.80.8
Rest time, locomotor task time 20.10.10.5-0.7-0.40.40.30.30.10.30.1
Distance moved, locomotor task time 20.50.61.00.61.0-0.9-0.9-0.8-0.7-0.8-0.5
Vertical activity count, locomotor time 21.52.13.5-0.61.9-1.5-1.5-1.5-1.5-1.5-1.3
Light reinforcement 10.10.20.50.70.2-0.5-0.5-0.4-0.1-0.4-0.2
Light reinforcement 20.81.22.00.00.4-1.4-1.4-1.3-1.1-1.3-1.0
Bone: marrow area0.10.20.8-0.6-0.90.30.30.30.30.30.1
Bone: maximum diameter0.10.10.2-0.00.2-0.5-0.5-0.4-0.3-0.4-0.4
Bone: maximum force0.00.00.3-0.50.1-0.0-0.1-0.1-0.1-0.1-0.3
Bone: maximum moment0.10.10.3-0.60.3-0.2-0.2-0.2-0.3-0.3-0.5
Mean time between licks in bursts0.51.22.2-0.5-0.11.51.41.31.01.30.8
Mean num. licks in bursts0.60.92.9-1.70.8-0.6-0.6-0.7-1.0-0.7-1.1
Cd content in liver0.50.50.80.2-0.30.90.90.90.70.80.7
Co content in liver0.00.00.2-0.40.10.10.10.1-0.10.1-0.1
Cu content in liver0.50.63.6-1.90.40.40.40.3-0.30.2-0.4
Fe content in liver0.30.40.70.1-0.2-0.8-0.8-0.8-0.4-0.7-0.5
K content in liver0.50.53.3-1.80.30.50.40.3-0.40.2-0.3
Mg content in liver2.32.35.5-2.31.7-0.9-1.0-1.1-1.7-1.2-1.6
Mn content in liver0.30.30.40.4-0.50.60.60.60.60.60.6
Na content in liver0.30.40.6-0.4-0.60.70.70.70.40.70.5
Rb content in liver0.10.20.9-0.90.40.10.0-0.0-0.3-0.1-0.3
Se content in liver0.10.10.6-0.70.50.30.20.2-0.10.2-0.1
Sr content in liver0.00.00.00.1-0.20.00.00.00.10.00.1
Zn content in liver0.40.51.6-1.20.30.80.80.70.10.60.1
Bone: minimum diameter0.91.64.1-2.01.1-0.8-0.9-1.0-1.3-1.0-1.5
Time in familiar zone, hab. session 10.40.40.70.6-0.50.50.60.60.80.60.6
Time in novel zone, hab. session 10.10.10.6-0.8-0.20.30.30.2-0.20.20.1
Total zone transitions, hab. session 10.30.41.11.0-1.00.30.30.40.60.40.7
Total locomotion distance, hab. session 10.20.31.31.1-0.5-0.6-0.5-0.40.0-0.40.0
Locomotion velocity, hab. session 10.20.21.11.0-0.6-0.4-0.3-0.30.1-0.20.1
Time in familiar zone, hab. session 20.30.31.3-1.10.50.60.50.50.00.4-0.0
Time in novel zone, hab. session 20.10.10.40.6-0.6-0.2-0.2-0.10.2-0.10.1
Total zone transitions, hab. session 20.10.10.4-0.70.1-0.1-0.2-0.2-0.4-0.2-0.3
Total locomotion distance, hab. session 20.40.50.6-0.30.4-0.8-0.8-0.8-0.7-0.8-0.8
Locomotion velocity, hab. session 20.40.50.7-0.20.4-0.9-0.8-0.8-0.7-0.8-0.8
Novel to familiar place preference ratio1.92.03.4-1.91.4-1.1-1.2-1.2-1.6-1.3-1.5
Novelty place preference1.01.12.2-1.51.0-0.8-0.8-0.9-1.2-0.9-1.1
Time in novel zone, NPP test0.80.92.1-1.50.8-0.7-0.7-0.7-1.0-0.8-1.0
Total zone transitions, NPP test0.50.81.30.40.4-1.2-1.1-1.1-0.7-1.0-0.8
Total locomotion distance, NPP test0.71.01.60.20.4-1.3-1.2-1.2-0.9-1.2-0.9
Locomotion velocity, NPP test1.21.62.50.10.8-1.6-1.6-1.5-1.2-1.5-1.2
Intraocular pressure0.30.40.6-0.70.4-0.6-0.6-0.6-0.7-0.7-0.8
Delta distance traveled before/after self-admin1.51.61.9-0.81.3-1.2-1.3-1.3-1.4-1.3-1.4
Delta ambulatory time before/after self-admin0.91.11.3-0.71.0-1.1-1.1-1.1-1.1-1.1-1.2
Parametrial fat weight0.00.10.20.4-0.30.10.10.10.30.20.1
Pavlov. Cond. lever latency1.21.52.4-0.2-0.51.51.51.51.31.41.0
Pavlov. Cond. magazine entry latency0.20.30.8-0.2-0.90.60.60.60.40.60.5
Pavlov. Cond. change in total contacts0.00.00.10.2-0.2-0.1-0.1-0.0-0.1-0.00.2
Pavlov. Cond. index score0.20.20.4-0.1-0.1-0.6-0.6-0.6-0.6-0.6-0.3
Pavlov. Cond. latency score0.30.30.6-0.1-0.1-0.7-0.7-0.7-0.8-0.7-0.4
Pavlov. Cond. lever contacts0.81.01.60.20.3-1.3-1.2-1.2-1.1-1.2-0.8
Pavlov. Cond. magazine entry number0.30.41.10.01.1-0.6-0.6-0.6-0.5-0.6-0.6
Pavlov. Cond. intertrial magazine entries1.31.62.1-1.41.4-1.0-1.1-1.1-1.3-1.2-1.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.20.1-0.8-0.8-0.7-0.8-0.7-0.5
Pavlov. Cond. response bias0.00.10.20.2-0.5-0.2-0.2-0.2-0.2-0.20.1
Pavlov. Cond. lever latency0.81.05.62.4-0.60.10.20.40.90.41.0
Pavlov. Cond. magazine entry latency0.81.05.7-2.4-0.20.90.80.7-0.10.6-0.1
Pavlov. Cond. change in total contacts0.60.95.4-2.30.80.10.0-0.1-0.8-0.2-0.8
Pavlov. Cond. index score0.91.28.1-2.90.20.50.40.2-0.60.2-0.6
Pavlov. Cond. latency score0.81.17.8-2.80.20.50.30.2-0.60.1-0.6
Pavlov. Cond. lever contacts0.60.84.6-2.10.4-0.1-0.2-0.3-0.8-0.3-0.8
Pavlov. Cond. magazine entry number1.21.54.62.20.6-1.5-1.4-1.2-0.4-1.1-0.4
Pavlov. Cond. intertrial magazine entries0.40.63.51.9-0.30.20.20.30.70.40.8
Pavlov. Cond. lever-magazine prob. diff.1.01.39.2-3.00.20.60.40.3-0.60.2-0.6
Pavlov. Cond. response bias0.50.75.1-2.30.10.50.40.3-0.40.2-0.4
Time in closed arm before self-admin0.40.50.80.8-0.40.70.70.80.70.80.9
Time in closed arm after self-admin0.20.30.80.90.00.40.40.50.50.50.5
Time in open arm before self-admin0.20.21.0-1.00.1-0.1-0.2-0.2-0.2-0.2-0.5
Time in open arm after self-admin0.91.01.8-1.30.1-1.0-1.0-1.0-1.0-1.0-1.0
Bone: periosteal estimation0.30.60.8-0.60.5-0.8-0.8-0.8-0.7-0.8-0.9
Bone: periosteal perimeter0.10.20.7-0.90.2-0.3-0.3-0.4-0.4-0.4-0.6
Bone: post-yield work0.10.10.4-0.5-0.60.20.20.20.20.20.0
Progressive ratio test 1 active lever presses0.60.71.10.21.1-0.9-0.9-0.9-0.8-0.9-0.6
Progressive ratio test 1 breakpoint0.60.71.10.31.0-1.0-0.9-0.9-0.8-0.9-0.5
Progressive ratio test 1 inactive lever presses0.30.40.70.30.9-0.7-0.7-0.7-0.6-0.6-0.4
Progressive ratio test 2 active lever presses0.60.72.90.41.7-0.7-0.7-0.6-0.7-0.6-0.3
Progressive ratio test 2 breakpoint0.50.62.40.61.5-0.7-0.7-0.6-0.6-0.6-0.3
Progressive ratio test 2 inactive lever presses0.20.21.70.01.3-0.2-0.2-0.2-0.3-0.20.0
Incentive Sensitization - Responses0.10.10.80.20.90.00.00.0-0.10.00.1
Incentive Sensitization - Breakpoint0.10.10.70.10.9-0.0-0.0-0.0-0.1-0.00.0
Sum of active levers in priming session hrs 5-60.10.10.40.7-0.3-0.4-0.3-0.3-0.1-0.2-0.0
Progressive ratio0.20.40.5-0.50.5-0.6-0.6-0.7-0.7-0.7-0.7
Food seeking constrained by brief footshock2.93.64.51.1-1.62.02.02.02.02.02.1
Seeking ratio, punishment vs. effort2.94.24.81.1-2.02.22.22.22.22.22.2
Retroperitoneal fat weight0.10.30.40.2-0.50.60.60.60.60.60.5
Reaction time number correct0.20.31.81.30.10.00.10.10.50.20.4
Reaction time mean minus median0.30.75.2-2.30.40.30.20.1-0.5-0.0-0.4
Reaction time mean minus median AUC0.20.43.1-1.80.30.30.30.2-0.30.1-0.3
Reaction time num false alarms1.42.04.1-2.00.7-1.2-1.2-1.3-1.7-1.3-1.5
Reaction time num false alarms AUC2.23.55.5-2.31.2-1.6-1.7-1.8-2.2-1.8-2.0
Reaction time trials correct on left0.20.31.81.30.10.00.10.10.50.20.4
Reaction time trials on left0.10.21.51.20.10.00.10.10.50.20.4
Reaction time mean0.30.53.4-1.8-0.20.50.40.4-0.20.30.0
Reaction time mean AUC0.30.52.1-1.5-0.40.70.70.60.10.50.3
Median of all reaction times0.30.41.6-1.3-0.50.60.60.50.10.50.3
Reaction time omissions0.91.36.0-2.41.3-0.3-0.4-0.5-1.1-0.6-0.9
Reaction time false alarm rate2.83.87.7-2.81.1-1.6-1.7-1.8-2.3-1.8-2.1
Reaction time premature initiation rate0.10.10.5-0.70.20.40.30.30.10.30.2
Reaction time premature initiations0.10.20.30.10.30.50.50.50.40.50.5
Std. dev. reaction times0.50.96.0-2.50.70.1-0.0-0.1-0.8-0.2-0.6
Reaction time trials completed0.10.21.51.20.10.00.10.10.50.20.4
Reaction time trials AUC0.10.21.11.10.4-0.2-0.1-0.10.3-0.00.1
Run reversals in cocaine runway, females0.20.20.7-0.8-0.50.40.40.30.10.30.3
Run reversals in cocaine runway, males2.62.64.1-2.00.8-1.5-1.6-1.6-1.7-1.7-1.7
Latency to leave start box in cocaine runway0.60.61.00.30.3-1.0-1.0-0.9-0.8-0.9-0.8
Latency to leave start box in cocaine runway, F1.01.11.80.50.5-1.4-1.3-1.2-1.0-1.2-1.0
Latency to leave start box in cocaine runway, M0.10.10.4-0.7-0.00.20.20.20.10.10.1
Std. dev. time between licks in bursts1.72.33.30.2-1.01.81.81.81.51.71.5
Total sessions with >9 infusions0.00.10.2-0.40.50.10.10.1-0.00.10.2
Short access day 1 total inactive lever presses1.51.92.7-0.11.7-1.5-1.5-1.5-1.4-1.5-1.4
Short access day 10 total inactive lever presses0.10.31.0-0.11.0-0.5-0.5-0.5-0.5-0.5-0.7
Short access day 1 total infusions0.10.10.60.40.8-0.1-0.1-0.0-0.0-0.00.0
Short access day 10 total infusions0.20.31.41.20.7-0.4-0.3-0.2-0.1-0.20.2
Short access total infusions0.10.10.50.30.70.20.20.20.20.20.3
Short access day 1 locomotion1.11.42.2-1.11.5-1.1-1.1-1.1-1.3-1.2-1.0
Short access day 10 total locomotion0.30.60.8-0.30.3-0.9-0.9-0.9-0.8-0.9-0.7
Short access total locomotion0.10.10.10.2-0.20.20.20.20.20.20.4
One hour access (0.3 mA shock)0.10.10.2-0.10.40.40.30.30.20.30.5
Compulsive drug intake0.91.12.00.9-1.40.91.01.01.11.00.9
One hour access (shock baseline)1.01.63.5-0.71.9-1.2-1.2-1.2-1.3-1.2-1.0
Social response proportion0.10.10.2-0.40.10.40.40.40.20.40.4
Social responses0.91.21.8-0.0-0.21.41.31.31.11.31.2
Social time0.30.41.6-0.51.3-0.3-0.3-0.4-0.3-0.4-0.6
Soleus weight2.67.89.7-0.72.7-3.1-3.1-3.1-2.9-3.1-2.8
Bone: stiffness0.00.00.1-0.20.30.10.10.1-0.00.0-0.0
Tibialis anterior weight2.58.513.41.12.2-3.7-3.6-3.4-2.6-3.3-2.5
Time to tail flick, vehicle, before self-admin1.61.72.4-0.10.8-1.5-1.5-1.5-1.4-1.4-1.3
Time to tail flick, vehicle, after self-admin0.40.60.80.80.3-0.9-0.8-0.8-0.5-0.8-0.9
Time to tail flick, test, before self-admin1.91.93.01.60.7-1.7-1.6-1.5-1.0-1.4-1.2
Time to tail flick, test, after self-admin1.11.21.91.01.4-1.2-1.1-1.1-0.7-1.0-1.0
Delta time to tail flick, vehicle, before/after SA0.00.00.20.4-0.2-0.1-0.1-0.10.1-0.1-0.2
Delta time to tail flick, test, before/after SA0.20.20.9-0.90.30.30.30.20.10.2-0.0
Tibia length0.20.40.6-0.20.6-0.7-0.7-0.7-0.6-0.7-0.8
Ambulatory time before self-admin0.00.00.20.4-0.1-0.2-0.2-0.20.1-0.2-0.1
Ambulatory time after self-admin0.40.50.80.20.4-0.9-0.9-0.9-0.5-0.8-0.8
Bone: tissue strength0.50.50.8-0.7-0.50.90.90.80.50.80.4
Total heroin consumption0.30.40.60.4-0.70.60.60.60.80.60.6
Bone: trabecular number0.61.01.20.3-1.01.11.11.11.11.11.0
Bone: trabecular spacing1.01.31.80.31.2-1.3-1.3-1.3-1.0-1.3-1.1
Bone: trabecular thickness0.40.50.7-0.5-0.70.90.80.80.50.80.6
Bone: trabecular tissue density0.40.51.11.0-0.60.60.60.60.90.70.8
Water consumed over 24 hours1.21.62.5-1.41.2-1.1-1.1-1.1-1.6-1.2-1.3
Number of responses in last shaping day2.72.93.5-0.91.9-1.7-1.8-1.8-1.8-1.8-1.8