Zscan18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Zscan18	0.37	0.19	5.1e-03	0.01	0.01	0.02	0.01	3.5e-02	3.3e-02	3.6e-03	8.8e-02
2	IC	gene expression	Zscan18	0.4	0.2	9.3e-04	0.05	0.05	0.03	0.02	5.4e-03	4.1e-03	2.4e-02	3.7e-02
3	pVTA	gene expression	Zscan18	0.44	0.14	6.9e-11	0	0.13	0.14	0.13	1.3e-01	2.1e-10	3.5e-11	1.9e-10
4	Liver	gene expression	Zscan18	0.61	0.15	0.0e+00	0.14	0.19	0.21	0.2	9.9e-15	6.1e-21	4.1e-23	4.4e-22
5	Adipose	gene expression	Zscan18	0.67	0.13	0.0e+00	0.17	0.25	0.27	0.28	3.4e-18	2.9e-27	9.2e-30	1.3e-30
6	NAcc	gene expression	Zscan18	0.42	0.13	0.0e+00	0.13	0.16	0.15	0.15	2.2e-19	4.0e-24	1.7e-22	1.3e-21
7	Brain	intron excision ratio	chr1_82483925_82493934	0.02	0.02	6.5e-03	0.01	0	0	0	7.8e-02	1.9e-01	2.8e-01	1.8e-01
8	PL	gene expression	Zscan18	0.27	0.13	2.2e-06	0.04	0.05	0.05	0.04	2.6e-05	6.8e-06	3.1e-06	7.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.4	0.6	2.7	-1.2	-0.8	-1.6	-0.2	0.2	-0.1	-0.4	0.3
Area under the delay curve	0.9	1.1	1.7	-0.2	-1.2	-0.2	-1.1	-1.1	-1.3	1.2	-1.1
BMI with tail	0.5	1.6	3.1	0.1	-0.7	-1.0	-1.2	-1.4	-1.5	1.8	-1.6
BMI without tail	0.1	0.2	0.7	0.8	-0.0	-0.4	0.2	0.3	-0.3	0.5	-0.7
Body weight	0.5	2.0	5.2	0.6	0.9	0.6	2.1	2.3	1.6	-1.3	0.8
Weight adjusted by age	0.3	0.4	1.5	-1.2	-1.1	-0.5	0.0	0.3	-0.0	-0.8	0.2
Bone surface	1.9	3.4	6.2	-0.7	0.6	0.3	2.0	2.4	2.1	-2.5	2.4
Bone volume	1.6	2.9	5.5	-0.4	0.7	-0.1	1.9	2.4	2.0	-2.2	2.1
Breakpoint value in progressive ratio session	0.7	0.8	1.9	1.4	0.2	0.8	-0.2	-0.5	-0.8	1.3	-1.1
Number of licking bursts	0.3	0.4	1.6	0.9	0.5	1.3	0.5	0.3	0.2	0.2	-0.1
Context. condit. distance diff. score	0.5	0.6	2.0	-1.4	-1.0	-0.5	-0.8	-0.8	-0.6	-0.3	0.2
Locomotion velocity, session 1	0.7	0.8	2.7	-1.2	-1.1	1.7	-0.2	0.2	-0.1	-0.8	0.3
Locomotion distance, session 1	0.9	1.1	3.0	-1.4	-0.8	-0.0	0.7	1.3	0.9	-1.7	0.8
Locomotion velocity, session 2	0.2	0.3	1.2	-1.1	-0.7	-0.3	-0.3	-0.1	-0.1	-0.4	0.3
Locomotion distance, session 2	1.0	1.4	3.0	-0.4	0.3	-0.5	1.3	1.7	1.4	-1.6	1.4
Locomotion velocity, session 3	0.1	0.1	0.3	0.0	0.3	-0.0	0.2	0.2	0.3	-0.4	0.6
Locomotion distance, session 3	1.3	1.5	6.2	-2.5	-1.3	-1.2	-0.5	-0.1	-0.0	-1.2	1.0
Stereotopy head waving bouts, day 3	0.8	1.0	3.4	1.8	0.8	1.8	0.3	0.0	0.1	0.5	-0.6
Stereotopy head waving duration, day 3	0.9	1.0	4.0	2.0	0.9	1.6	0.3	0.1	0.1	0.5	-0.7
Locomotion velocity, session 7	0.3	0.3	0.9	0.0	0.3	-0.9	0.4	0.6	0.5	-0.6	0.5
Locomotion distance, session 7	0.1	0.1	0.9	-0.4	-0.3	-0.9	-0.0	0.2	0.0	-0.2	0.0
Stereotopy head waving bouts, day 7	0.7	0.8	2.0	0.4	1.0	1.4	0.6	0.4	0.9	-0.9	1.1
Stereotopy head waving duration, day 7	0.4	0.4	1.0	0.4	0.7	1.0	0.5	0.4	0.6	-0.6	0.7
Locomotion velocity, session 8	0.3	0.3	1.6	-0.7	-0.6	-1.3	-0.2	-0.1	-0.2	-0.3	0.1
Locomotion distance, session 8	0.5	0.7	2.5	-1.6	-0.9	-0.7	-0.3	0.1	-0.0	-1.0	0.7
Degree of sensitization distance	0.4	0.5	1.9	1.4	0.5	0.7	0.3	0.2	-0.0	0.6	-0.8
Degree of sensitization stereotypy	0.5	0.5	1.5	-1.0	0.2	0.7	-0.0	-0.1	0.4	-0.9	1.2
Conditioned locomotion	0.3	0.4	0.7	-0.9	-0.8	-0.8	-0.5	-0.1	-0.5	0.1	-0.5
Cocaine response after cond. corrected	2.0	2.4	7.1	2.6	2.7	2.1	0.7	-0.2	0.7	0.7	0.2
Cocaine response after cond. not corrected	1.7	2.0	4.8	1.8	2.2	1.6	1.4	0.9	1.4	-0.4	0.9
Cocaine response before conditioning	1.9	2.3	4.6	-1.9	-1.2	-1.0	1.1	1.9	1.2	-2.2	1.2
Saline control response	0.9	1.2	4.3	-1.8	-1.0	-2.1	-0.2	0.2	0.1	-0.8	0.5
Bone: connectivity density	0.5	0.7	2.8	-1.7	-1.0	-0.9	-0.8	-0.3	-0.5	-0.2	0.4
Bone: cortical apparent density	0.4	0.5	2.0	1.4	0.4	-0.5	0.6	0.8	0.1	0.5	-0.4
Bone: cortical area	0.6	1.0	2.8	-1.4	-1.4	-1.7	0.1	0.9	0.0	-0.7	0.1
Bone: cortical porosity	0.1	0.2	0.5	0.2	0.3	-0.2	-0.4	-0.7	-0.3	0.4	-0.3
Bone: cortical porosity	0.2	0.2	0.7	0.7	0.8	0.4	0.1	-0.1	0.2	0.1	0.2
Bone: cortical thickness	1.0	1.7	5.2	-0.5	-1.4	-2.3	-0.9	-0.5	-1.3	1.1	-1.4
Bone: cortical thickness	0.1	0.1	0.4	0.0	-0.1	-0.4	0.4	0.6	0.2	-0.3	0.3
Bone: cortical tissue density	0.4	0.5	2.2	1.5	0.5	-0.3	0.7	0.8	0.2	0.5	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	2.7	1.6	1.1	0.5	0.6	0.3	0.4	0.3	0.0
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.5	0.6	0.0	-0.8	-0.7	-1.0	-0.9	1.2	-1.0
Condit. Reinf. active responses	1.2	1.4	2.4	1.5	1.5	1.1	1.3	1.0	1.1	-0.7	1.0
Condit. Reinf. inactive responses	2.2	2.7	4.3	0.3	1.0	1.4	1.8	1.9	1.8	-2.1	2.0
Incentive salience index mean	0.3	0.4	1.1	1.1	0.8	0.2	0.8	0.6	0.6	-0.3	0.3
Condit. Reinf. lever presses	0.2	0.3	0.7	0.1	0.1	-0.2	0.8	0.8	0.6	-0.6	0.3
Condit. Reinf. active minus inactive responses	1.4	1.8	4.0	-1.0	-0.1	0.3	1.3	1.7	1.5	-2.0	1.5
Condit. Reinf. active-inactive response ratio	2.3	2.6	5.3	0.0	0.5	1.3	1.7	2.3	1.8	-2.1	1.8
Condit. Reinf. active responses	1.1	1.6	3.6	-1.9	-0.9	-0.7	0.9	1.2	1.0	-1.8	1.0
Condit. Reinf. inactive responses	1.0	1.3	3.7	-1.7	-1.5	-1.9	-0.6	-0.7	-0.7	0.1	-0.6
Condit. Reinf. lever presses	0.6	0.8	2.4	-1.5	-1.1	-1.4	-0.6	-0.4	-0.5	-0.1	-0.3
Condit. Reinf. lever reinforcers received	1.5	2.1	4.7	-2.1	-0.8	-0.7	1.1	1.5	1.2	-2.2	1.4
Conditioned reinforcement - actives	1.3	2.1	6.2	2.5	2.1	1.1	1.3	1.3	1.2	-0.4	0.7
Conditioned reinforcement - inactives	1.1	1.6	3.7	0.8	0.6	1.1	1.7	1.9	1.2	-1.3	1.0
Conditioned locomotion	1.0	1.4	5.1	2.3	1.4	1.5	0.8	0.7	0.6	-0.0	0.3
Patch foraging indifference point 0 sec	1.3	2.5	6.2	-1.4	-2.5	-0.8	-1.7	-1.3	-2.0	0.9	-1.3
Patch foraging indifference point AUC	0.2	0.3	0.4	0.7	0.4	0.1	-0.7	-0.6	-0.3	0.6	-0.3
Delay disc. indifference point, 0s delay	3.9	4.3	10.1	-3.2	-3.0	-2.8	-1.7	-1.2	-1.4	0.1	-0.9
Delay disc. indifference point, 16s delay	3.1	3.4	13.2	3.6	1.9	3.1	0.5	-0.1	0.2	0.9	0.3
Delay disc. indifference point, 2s delay	0.8	0.9	1.4	-0.8	-1.0	-0.7	-0.9	-1.1	-1.0	0.8	-1.2
Delay disc. indifference point, 24s delay	1.0	1.1	4.3	2.1	1.2	1.4	0.2	-0.4	-0.1	0.9	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.5	-0.2	-0.5	0.2	0.1	0.1	0.2	-0.2
Delay disc. indifference point, 8s delay	1.3	1.5	3.0	-0.6	-1.7	-0.4	-1.4	-1.0	-1.6	1.1	-1.3
Indifference point function ln k	1.4	2.5	5.8	-1.3	-0.4	-0.5	1.9	2.1	1.6	-2.4	1.3
Indifference point function log k	1.4	2.5	5.8	-1.3	-0.4	-0.5	1.9	2.1	1.6	-2.4	1.3
Patch foraging total patch changes 0 sec	1.3	2.4	6.1	-1.2	-2.5	-0.8	-1.6	-1.3	-2.0	1.0	-1.4
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	0.0	-0.2	-0.3	-0.7	-0.8	-0.6	0.7	-0.4
Patch foraging total patch changes 18 sec	0.7	1.1	1.6	-0.8	-1.3	-0.4	-1.3	-1.2	-1.3	0.9	-0.9
Patch foraging total patch changes 24 sec	0.8	1.4	4.8	1.5	1.2	2.2	0.5	0.7	0.7	-0.4	1.2
Patch foraging total patch changes 6 sec	0.6	1.0	1.8	0.5	-0.4	-0.1	-1.1	-1.3	-1.2	1.3	-1.3
Patch foraging time to switch 0 sec	2.6	5.2	19.8	4.4	3.8	2.1	0.6	-0.3	0.6	1.6	0.2
Patch foraging water rate 0 sec	0.9	2.0	7.9	-2.8	-2.2	-1.3	-0.6	-0.0	-0.5	-0.7	-0.3
Patch foraging water rate 12 sec	1.6	3.4	12.7	-3.6	-2.6	-2.4	-0.3	0.2	-0.3	-0.9	-0.7
Patch foraging water rate 18 sec	0.8	1.2	4.5	-2.1	-1.7	-1.1	-0.4	0.2	-0.4	-0.4	-0.7
Patch foraging water rate 24 sec	0.5	0.7	2.1	-1.5	-1.0	0.6	0.2	0.5	0.2	-1.2	0.4
Patch foraging water rate 6 sec	3.3	4.9	8.5	-0.8	0.8	1.4	2.6	2.8	2.6	-2.9	2.4
Seeking ratio, delayed vs. immediate footshock	5.8	7.1	19.8	-4.5	-3.6	-3.3	-2.1	-1.5	-1.8	0.2	-1.6
Distance traveled before self-admin	2.8	3.7	12.3	-3.5	-3.5	-1.5	-0.8	-0.2	-1.0	-1.0	-0.6
Distance traveled after self-admin	7.7	9.5	21.5	-4.6	-4.6	-3.0	-2.9	-2.3	-2.8	0.5	-1.7
Extensor digitorum longus weight	0.1	0.2	0.6	-0.5	-0.2	-0.5	0.6	0.7	0.3	-0.5	0.4
Bone: elastic displacement	1.2	1.4	2.5	-0.2	-1.4	1.6	-1.3	-1.1	-1.4	0.9	-1.1
Bone: elastic work	0.7	0.9	3.8	-1.4	-1.9	-0.4	-0.7	-0.2	-0.9	-0.0	-0.6
Bone: endosteal estimation	1.7	3.8	8.6	-0.8	0.9	1.0	1.8	1.8	2.4	-2.9	2.6
Bone: endosteal perimeter	0.8	1.7	4.5	-1.0	-0.1	0.6	1.1	1.5	1.4	-2.1	1.7
Epididymis fat weight	0.4	1.2	3.4	1.8	1.9	1.0	0.9	0.8	0.8	0.3	0.1
Delta time in closed arm before/after self-admin	0.8	0.7	4.5	-0.6	-0.5	-2.1	-0.6	-0.4	-0.2	0.2	-0.3
Delta time in open arm before/after self-admin	1.7	1.6	5.6	1.0	0.4	2.4	1.0	1.2	0.8	-1.3	1.2
Diff in mean of infusions in LGA sessions	1.0	1.3	2.8	-1.3	-1.7	-1.4	-0.8	-0.5	-1.1	0.6	-1.2
Delay discount exponential model param	0.8	0.9	1.5	0.2	1.1	0.2	1.0	1.0	1.2	-1.1	1.1
Extinction: sum of active levers before priming	0.1	0.2	0.4	-0.4	-0.6	-0.1	-0.4	-0.4	-0.2	-0.3	0.6
Active lever presses in extinction session 6	2.5	2.5	7.0	2.6	2.6	1.4	1.1	0.8	1.2	0.2	0.7
Bone: final force	0.8	1.3	2.7	-0.8	-0.3	-0.9	1.3	1.6	1.2	-1.5	1.0
Bone: final moment	1.1	1.7	3.2	-1.3	-0.6	-0.8	1.3	1.8	1.2	-1.8	1.2
Food consumed during 24 hour testing period	0.2	0.3	1.1	0.3	-0.1	-0.8	0.7	1.0	0.4	-0.3	-0.2
Glucose	2.5	4.0	6.8	-0.7	-1.6	-2.6	-1.9	-2.0	-2.0	2.1	-2.4
Heart weight	0.6	1.0	1.9	1.4	0.9	-1.2	1.3	1.1	0.9	-0.1	-0.2
Delay discount hyperbolic model param	1.2	1.3	2.0	0.5	1.4	0.5	1.1	1.2	1.4	-1.2	1.3
Intermittent access intake day 1-15 change	0.8	1.7	2.8	1.7	1.4	1.3	1.7	1.5	1.1	-0.6	0.7
Intermittent access intake escalation	1.6	3.3	5.2	2.3	2.0	2.1	2.2	1.9	1.6	-0.9	1.0
Intermittent access intake escalation 2	0.3	0.3	1.4	-0.5	-0.5	-1.2	0.2	0.3	-0.2	0.3	-0.6
Intermitt. access day 1 inactive lever presses	2.0	7.6	16.7	4.1	2.8	3.9	2.5	2.3	1.9	-1.5	2.0
Intermitt. access day 15 inactive lever presses	3.0	6.1	7.9	2.8	2.7	2.7	2.3	2.4	2.3	-2.0	2.5
Intermitt. access escalation Index	0.5	0.7	1.5	1.2	-0.1	0.6	-0.3	-0.6	-0.7	1.0	-1.2
Intermittent access day 1 total infusions	0.8	1.3	2.3	1.2	1.3	1.5	0.9	1.0	1.1	-0.8	1.1
Intermittent access day 15 total infusions	3.6	5.4	12.2	3.5	2.7	3.2	2.2	2.0	1.7	-0.7	1.1
Intermittent access terminal intake (last 3 days)	2.0	2.7	4.4	2.0	2.1	1.9	1.7	1.7	1.4	-0.6	0.9
Intermittent access total infusions	3.4	4.0	6.3	2.4	2.3	2.5	2.0	1.9	1.7	-1.2	1.6
Intermittent access day 1 locomotion	1.8	2.2	4.1	2.0	1.6	1.4	1.6	1.6	1.4	-1.0	1.1
Intermittent access day 15 total locomotion	0.2	0.4	1.3	0.8	-0.2	0.6	0.8	1.1	0.3	-0.6	-0.2
Intermittent access total locomotion	2.8	3.3	5.5	1.9	1.7	1.5	2.2	2.3	1.9	-1.6	1.3
Intermittent access standard deviation	0.2	0.5	1.1	0.4	-0.2	0.2	-0.5	-0.5	-0.9	1.0	-1.1
Left kidney weight	2.2	10.4	21.5	0.2	1.5	0.4	4.0	4.6	3.7	-4.2	3.4
Right kidney weight	2.6	11.8	23.8	1.3	2.2	1.1	4.4	4.9	3.9	-4.1	3.5
Cocaine induced anxiety	1.1	1.5	2.1	0.8	0.9	1.2	1.4	1.4	1.3	-1.3	1.3
Post-drug Anxiety	2.6	2.8	4.2	1.7	2.0	1.3	1.6	1.5	1.8	-1.3	2.0
Baseline Anxiety	0.4	0.4	1.5	-0.3	-0.2	-1.2	-0.7	-0.8	-0.5	0.6	-0.3
Tail length	1.3	5.0	10.6	0.3	1.0	0.9	3.0	3.3	2.5	-2.9	2.0
Length with tail	2.0	8.6	15.8	0.9	2.3	1.9	3.8	4.0	3.4	-3.2	2.7
Length without tail	2.8	8.9	12.8	2.4	3.6	2.8	3.5	3.4	3.4	-2.0	2.4
Times rat made contact with spout	0.6	0.6	1.9	-1.0	-0.7	-1.4	-0.7	-0.7	-0.6	0.5	-0.4
Lifetime Intake	2.3	2.9	4.2	2.0	2.0	2.0	1.7	1.6	1.5	-1.0	1.3
Liver weight, left	0.8	1.3	2.6	0.6	0.7	0.8	1.6	1.6	1.2	-1.2	0.8
Liver weight, right	0.3	0.5	1.0	-0.7	-1.0	-1.0	-0.4	-0.3	-0.7	0.4	-1.0
Locomotor activity	0.3	0.4	0.8	-0.5	-0.6	-0.9	-0.6	-0.7	-0.8	0.6	-0.4
Locomotor testing distance	0.1	0.1	0.4	0.3	0.6	0.1	0.3	0.0	0.2	0.1	0.4
Locomotor testing rearing	0.1	0.3	0.7	-0.7	-0.1	-0.1	0.2	0.3	0.3	-0.8	0.8
Locomotion in novel chamber	0.8	1.0	4.4	-0.2	-0.5	2.1	-0.8	-1.1	-0.8	0.8	-0.1
Locomotion in novel chamber post-restriction	0.6	1.0	1.3	-1.0	-0.9	-0.6	-1.0	-1.1	-1.1	1.1	-1.1
Fecal boli incidents, locomotor time 1	0.4	0.5	2.0	-1.0	-0.9	-1.4	-0.3	0.1	-0.3	0.0	-0.3
Change in fecal boli incidents, locomotor task	2.7	2.7	4.9	-0.4	-0.9	-2.2	-1.6	-1.8	-1.6	1.9	-1.9
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.8	1.3	0.8	0.5	0.4	0.4	0.1	0.2	0.3
Bouts of movement, locomotor time 1	3.4	3.9	8.9	-2.9	-2.9	-3.0	-1.3	-0.7	-1.3	0.3	-1.3
Total resting periods, locomotor time 1	2.3	2.6	7.7	-2.0	-2.0	-2.8	-1.1	-0.7	-1.1	0.6	-1.2
Rest time, locomotor task time 1	0.7	0.9	3.4	-0.6	0.2	-1.9	0.9	1.1	0.9	-0.4	0.2
Distance moved, locomotor task time 1	0.7	1.0	3.9	0.5	-0.4	2.0	-1.0	-1.2	-1.0	0.4	-0.2
Vertical activity count, locomotor time 1	2.1	5.1	9.7	-1.7	-3.1	-0.7	-2.8	-2.6	-2.9	1.2	-1.7
Time >=10cm from walls, locomotor time 2	0.2	0.4	1.2	1.1	1.0	0.5	0.1	-0.2	0.1	0.6	0.3
Bouts of movement, locomotor time 2	0.0	0.1	0.3	-0.5	-0.4	-0.1	0.0	-0.0	-0.1	0.1	0.1
Total resting periods, locomotor time 2	0.1	0.2	1.0	-1.0	-0.6	-0.5	-0.1	0.0	-0.1	0.1	-0.1
Rest time, locomotor task time 2	1.5	1.9	5.8	-2.4	-1.9	-1.9	-0.9	-0.5	-0.8	0.2	-0.6
Distance moved, locomotor task time 2	0.2	0.2	1.4	0.1	-0.0	1.2	-0.3	-0.5	-0.2	-0.2	0.3
Vertical activity count, locomotor time 2	0.8	1.2	2.4	-1.5	-1.5	-0.5	-1.2	-1.0	-1.1	0.3	-0.6
Light reinforcement 1	0.7	1.6	5.6	-2.4	-1.8	-1.1	-0.7	-1.1	-0.8	-0.0	-0.7
Light reinforcement 2	0.3	0.5	1.1	0.3	-0.1	0.2	-0.4	-0.9	-0.7	1.0	-1.0
Bone: marrow area	1.7	3.8	8.6	-0.9	0.9	0.9	1.8	1.8	2.4	-2.9	2.6
Bone: maximum diameter	0.4	0.8	1.5	-1.0	-1.0	-1.2	0.3	1.1	0.3	-1.0	0.6
Bone: maximum force	0.8	1.4	2.3	-1.2	-0.7	-1.2	1.1	1.5	1.0	-1.5	0.9
Bone: maximum moment	1.0	1.7	3.2	-1.6	-1.0	-1.1	1.1	1.6	1.0	-1.8	1.1
Mean time between licks in bursts	0.6	1.4	2.2	-0.8	-1.2	-0.7	-1.1	-1.2	-1.3	1.2	-1.5
Mean num. licks in bursts	0.8	1.2	5.9	-1.5	-0.8	-2.4	-0.8	-0.6	-0.5	0.0	-0.1
Cd content in liver	0.9	1.0	2.1	0.4	0.8	1.0	0.9	1.4	1.3	-1.1	0.8
Co content in liver	0.6	0.7	2.4	0.4	0.8	-0.5	1.0	1.5	1.1	-0.5	0.4
Cu content in liver	3.8	4.5	6.5	1.8	2.2	2.5	2.1	2.0	2.2	-1.8	2.0
Fe content in liver	2.1	2.5	3.8	2.0	1.8	1.9	1.7	1.6	1.4	-0.7	1.2
K content in liver	0.4	0.3	1.1	0.4	0.4	1.0	0.0	0.4	0.5	-0.7	0.7
Mg content in liver	0.8	0.8	2.1	1.2	1.3	1.4	0.4	0.5	0.6	-0.4	0.9
Mn content in liver	0.6	0.6	1.8	1.4	1.0	1.2	0.5	0.0	0.4	-0.3	0.7
Na content in liver	0.4	0.4	1.2	0.6	0.5	0.7	-0.8	-1.1	-0.5	0.4	-0.0
Rb content in liver	4.3	5.0	7.9	1.0	2.2	2.8	2.1	1.8	2.5	-2.5	2.4
Se content in liver	0.9	1.1	2.6	0.5	-0.2	0.7	-1.1	-1.6	-1.3	1.2	-0.9
Sr content in liver	11.3	9.8	12.6	-2.3	-3.4	-3.1	-3.4	-3.3	-3.6	2.7	-3.1
Zn content in liver	1.8	2.0	5.5	2.3	2.1	2.2	0.5	0.4	0.7	0.3	0.5
Bone: minimum diameter	1.3	2.3	5.5	-2.1	-1.1	-0.5	0.8	1.6	1.2	-2.3	1.6
Time in familiar zone, hab. session 1	1.6	1.6	6.8	-2.6	-1.9	-0.5	0.1	0.5	0.2	-1.3	0.1
Time in novel zone, hab. session 1	1.6	1.6	6.6	2.6	2.1	0.9	0.4	0.1	0.3	0.8	0.4
Total zone transitions, hab. session 1	1.0	1.4	3.7	-1.9	-0.7	-1.1	0.4	0.8	0.8	-1.8	1.2
Total locomotion distance, hab. session 1	1.1	1.5	6.0	-2.4	-2.0	-0.9	-0.9	-0.3	-0.6	-0.5	-0.1
Locomotion velocity, hab. session 1	0.6	0.9	3.5	-1.9	-1.5	-0.3	-0.6	-0.1	-0.5	-0.6	0.1
Time in familiar zone, hab. session 2	2.5	2.6	5.1	1.0	1.3	2.3	1.8	1.7	1.7	-1.4	1.5
Time in novel zone, hab. session 2	0.6	0.6	2.3	0.1	-0.0	-1.5	-0.8	-0.9	-0.7	0.8	-0.5
Total zone transitions, hab. session 2	1.5	2.0	6.7	-2.6	-1.5	-1.0	-0.0	0.8	0.4	-1.9	1.0
Total locomotion distance, hab. session 2	2.0	2.7	7.4	-2.7	-2.7	-1.0	-1.6	-0.7	-1.5	0.0	-0.7
Locomotion velocity, hab. session 2	2.5	3.3	8.7	-2.9	-3.0	-1.2	-1.8	-1.0	-1.7	0.1	-0.9
Novel to familiar place preference ratio	0.6	0.7	1.5	-1.2	-1.1	-0.6	-0.8	-0.8	-0.7	0.2	-0.7
Novelty place preference	0.2	0.3	0.9	-0.9	-0.7	-0.4	-0.4	-0.4	-0.2	-0.1	-0.3
Time in novel zone, NPP test	0.1	0.2	0.6	-0.8	-0.5	-0.3	-0.2	-0.3	-0.1	-0.2	-0.2
Total zone transitions, NPP test	0.5	0.7	2.0	-1.4	-1.2	-1.3	-0.4	-0.1	-0.4	-0.3	-0.2
Total locomotion distance, NPP test	1.0	1.4	4.1	-1.6	-2.0	-0.6	-1.2	-0.5	-1.2	0.3	-0.9
Locomotion velocity, NPP test	1.2	1.7	5.0	-2.0	-2.2	-0.8	-1.3	-0.5	-1.2	0.1	-0.8
Intraocular pressure	0.2	0.3	0.5	0.4	0.6	-0.3	0.6	0.4	0.5	-0.4	0.7
Delta distance traveled before/after self-admin	1.7	1.8	3.1	-0.6	-1.1	-0.9	-1.7	-1.7	-1.7	1.4	-1.1
Delta ambulatory time before/after self-admin	1.6	2.0	2.8	-0.5	-1.2	-1.4	-1.6	-1.6	-1.7	1.5	-1.5
Parametrial fat weight	1.8	4.2	7.1	-0.0	-1.7	-1.1	-2.2	-2.1	-2.6	2.7	-2.5
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.2	0.2	0.6	0.1	0.1	0.1	-0.0	0.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	-0.5	-0.6	-1.0	-1.2	-1.1	-1.1	1.1	-0.8
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	-0.4	-0.5	-0.9	-0.7	-0.6	-0.6	0.4	-0.5
Pavlov. Cond. index score	0.4	0.5	0.8	-0.5	-0.6	-0.9	-0.9	-0.8	-0.8	0.6	-0.6
Pavlov. Cond. latency score	0.5	0.6	0.9	-0.5	-0.7	-1.0	-0.9	-0.8	-0.9	0.7	-0.8
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.1	0.2	-0.2	0.1	-0.0	0.0	-0.0	0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	1.0	0.7	1.3	1.0	0.8	0.8	-0.5	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	-0.7	-0.8	0.1	-0.1	-0.0	-0.1	-0.5	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	-0.4	-0.6	-0.7	-0.8	-0.8	-0.8	0.7	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.3	0.0	-0.5	-0.4	-0.4	-0.2	0.1	0.1
Pavlov. Cond. lever latency	3.3	4.5	7.2	2.7	2.6	1.9	2.3	2.2	2.2	-1.1	1.6
Pavlov. Cond. magazine entry latency	1.9	2.3	3.1	-1.0	-1.3	-1.3	-1.8	-1.7	-1.8	1.5	-1.5
Pavlov. Cond. change in total contacts	1.4	2.2	6.2	-2.5	-2.2	-1.8	-1.2	-0.9	-1.1	-0.1	-0.5
Pavlov. Cond. index score	1.7	2.3	4.0	-2.0	-1.9	-1.3	-1.7	-1.6	-1.6	0.7	-1.1
Pavlov. Cond. latency score	2.2	2.9	4.0	-1.8	-2.0	-1.3	-2.0	-1.9	-1.9	1.2	-1.5
Pavlov. Cond. lever contacts	2.7	3.8	7.1	-2.7	-2.5	-1.8	-2.0	-1.9	-1.8	0.8	-1.4
Pavlov. Cond. magazine entry number	1.1	1.3	1.9	1.1	1.1	0.8	1.3	1.4	1.3	-1.0	1.0
Pavlov. Cond. intertrial magazine entries	3.0	4.6	6.9	0.4	1.2	2.5	2.3	2.2	2.5	-2.6	2.3
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	3.7	-1.9	-1.9	-1.1	-1.7	-1.6	-1.6	0.8	-1.1
Pavlov. Cond. response bias	1.7	2.3	6.6	-2.6	-2.1	-1.5	-1.4	-1.3	-1.2	0.1	-0.7
Time in closed arm before self-admin	0.5	0.6	1.3	0.7	0.7	0.9	1.1	1.1	0.6	-0.3	-0.2
Time in closed arm after self-admin	0.3	0.3	0.7	0.6	0.9	0.0	0.7	0.6	0.6	-0.2	0.3
Time in open arm before self-admin	2.6	2.8	5.5	-1.8	-1.5	-2.3	-1.9	-1.8	-1.4	1.2	-1.1
Time in open arm after self-admin	0.3	0.4	0.7	-0.6	-0.8	0.6	-0.8	-0.7	-0.5	-0.1	0.1
Bone: periosteal estimation	1.0	2.2	5.2	-1.6	-0.5	-0.6	1.1	1.7	1.4	-2.3	1.8
Bone: periosteal perimeter	1.1	1.9	4.1	-1.5	-0.5	-0.1	1.1	1.6	1.3	-2.0	1.7
Bone: post-yield work	2.1	3.1	5.3	0.4	1.7	0.2	2.1	2.0	2.3	-2.0	2.1
Progressive ratio test 1 active lever presses	0.3	0.4	1.0	-0.7	-0.6	-0.1	0.2	0.5	0.3	-1.0	0.7
Progressive ratio test 1 breakpoint	0.3	0.3	0.9	-0.7	-0.7	-0.1	0.2	0.5	0.2	-1.0	0.7
Progressive ratio test 1 inactive lever presses	2.8	4.0	5.2	1.8	1.6	1.8	2.2	2.3	2.0	-2.1	2.1
Progressive ratio test 2 active lever presses	2.3	2.7	6.3	2.5	2.1	1.9	1.6	1.4	1.3	-0.3	0.9
Progressive ratio test 2 breakpoint	2.7	3.1	6.8	2.6	2.3	2.1	1.7	1.6	1.4	-0.4	1.1
Progressive ratio test 2 inactive lever presses	2.6	4.3	6.5	1.7	1.8	1.7	2.3	2.6	2.1	-2.2	2.1
Incentive Sensitization - Responses	4.0	5.7	13.3	3.6	3.1	2.2	2.5	2.3	2.0	-0.5	1.2
Incentive Sensitization - Breakpoint	3.9	5.1	12.4	3.5	3.1	2.2	2.3	2.1	1.9	-0.4	1.0
Sum of active levers in priming session hrs 5-6	0.5	0.4	1.0	-0.2	-1.0	0.4	-0.3	-0.4	-0.9	0.6	-1.0
Progressive ratio	1.4	2.2	5.6	-2.4	-1.9	-2.3	-1.4	-0.6	-0.9	0.3	-0.6
Food seeking constrained by brief footshock	24.6	30.1	71.1	-8.4	-8.1	-6.7	-4.4	-3.1	-4.2	1.0	-3.5
Seeking ratio, punishment vs. effort	0.8	1.1	3.4	-1.8	-1.8	-1.1	-0.3	-0.3	-0.6	-0.3	-0.8
Retroperitoneal fat weight	2.0	8.5	21.9	2.2	0.1	0.3	-2.7	-3.4	-3.1	4.7	-3.6
Reaction time number correct	1.4	2.6	6.3	-2.5	-2.0	-0.5	-1.9	-1.8	-1.4	0.5	-1.0
Reaction time mean minus median	0.1	0.3	1.0	0.6	1.0	0.3	0.4	0.5	0.6	-0.1	0.3
Reaction time mean minus median AUC	0.3	0.6	1.8	0.7	1.2	1.3	0.5	0.5	0.7	-0.2	0.7
Reaction time num false alarms	0.1	0.1	0.3	0.5	-0.5	-0.2	-0.2	0.5	-0.5	0.1	-0.1
Reaction time num false alarms AUC	0.4	0.6	1.9	-0.2	-1.4	-0.8	-0.9	-0.1	-1.1	0.3	-0.4
Reaction time trials correct on left	1.4	2.6	6.3	-2.5	-2.0	-0.5	-1.9	-1.8	-1.4	0.5	-1.0
Reaction time trials on left	1.4	2.5	6.1	-2.5	-2.0	-0.5	-1.9	-1.8	-1.4	0.5	-1.0
Reaction time mean	2.7	4.4	8.3	2.6	2.9	1.5	2.2	1.9	2.0	-1.3	1.9
Reaction time mean AUC	2.3	3.7	8.2	2.7	2.9	1.6	1.8	1.5	1.7	-0.8	1.6
Median of all reaction times	3.2	4.6	8.9	2.8	3.0	1.4	2.2	1.9	2.0	-1.2	2.0
Reaction time omissions	0.1	0.1	0.4	-0.2	-0.6	-0.6	-0.3	0.2	-0.4	0.0	0.0
Reaction time false alarm rate	0.2	0.3	1.2	1.1	-0.3	-0.5	0.1	0.8	-0.4	0.1	0.1
Reaction time premature initiation rate	0.3	0.5	2.6	-0.1	-0.0	-1.6	-0.1	0.1	-0.3	0.7	-0.7
Reaction time premature initiations	0.8	1.4	3.3	-1.2	-1.0	-1.8	-1.0	-0.9	-1.0	1.1	-1.2
Std. dev. reaction times	1.0	1.9	3.4	1.8	1.9	1.3	1.2	1.4	1.2	-0.8	1.2
Reaction time trials completed	1.4	2.5	6.1	-2.5	-2.0	-0.5	-1.9	-1.8	-1.4	0.5	-1.0
Reaction time trials AUC	1.2	2.4	5.5	-2.4	-1.9	-0.4	-1.8	-1.7	-1.4	0.6	-1.0
Run reversals in cocaine runway, females	1.9	1.9	6.2	2.5	1.2	2.0	1.2	1.1	0.6	-0.0	0.7
Run reversals in cocaine runway, males	0.5	0.5	1.0	0.5	1.0	0.6	0.8	0.6	0.8	-0.3	0.6
Latency to leave start box in cocaine runway	0.8	0.9	3.7	1.9	0.8	-0.1	1.3	0.9	0.7	0.2	-0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	3.1	1.8	0.3	-0.5	0.7	0.2	-0.0	0.8	-1.1
Latency to leave start box in cocaine runway, M	2.1	2.0	3.1	1.2	1.4	1.3	1.7	1.7	1.6	-1.1	1.1
Std. dev. time between licks in bursts	0.5	0.7	2.1	-1.2	-1.5	0.8	-0.6	-0.6	-0.7	0.1	-0.6
Total sessions with >9 infusions	1.4	1.7	3.1	0.5	0.8	1.2	1.3	1.4	1.4	-1.7	1.8
Short access day 1 total inactive lever presses	3.2	4.2	6.2	2.5	2.4	2.2	2.1	1.9	1.9	-1.1	1.8
Short access day 10 total inactive lever presses	0.1	0.2	0.4	0.6	0.6	-0.1	0.7	0.7	0.5	-0.1	-0.1
Short access day 1 total infusions	0.3	0.4	1.0	0.6	0.7	1.0	0.6	0.5	0.7	-0.4	0.6
Short access day 10 total infusions	0.2	0.3	1.3	0.6	0.5	1.1	0.2	0.1	0.2	-0.2	0.5
Short access total infusions	0.0	0.0	0.1	0.1	0.3	0.3	0.1	-0.0	0.1	0.0	0.2
Short access day 1 locomotion	2.7	3.4	6.2	2.2	2.5	0.9	1.9	1.7	2.0	-1.2	1.8
Short access day 10 total locomotion	0.3	0.5	1.5	-0.1	-0.5	-0.3	0.7	1.0	0.4	-1.2	0.8
Short access total locomotion	0.6	0.7	1.8	-1.3	-1.3	-1.3	-0.2	0.1	-0.3	-0.7	0.1
One hour access (0.3 mA shock)	5.4	6.3	8.6	2.8	2.8	1.8	2.9	2.9	2.6	-1.9	2.1
Compulsive drug intake	2.9	3.4	4.8	1.9	1.5	2.2	1.9	2.0	1.8	-1.8	1.8
One hour access (shock baseline)	1.6	2.4	6.4	2.5	2.5	0.7	1.4	1.3	1.3	-0.2	0.8
Social response proportion	3.7	4.2	8.4	2.9	2.9	2.0	2.4	1.7	1.9	-0.4	0.9
Social responses	4.7	6.0	9.8	1.9	2.8	2.4	3.1	2.7	2.8	-1.8	1.9
Social time	1.1	1.5	4.5	-2.1	-1.3	-0.0	0.9	1.1	0.7	-1.6	0.6
Soleus weight	0.2	0.6	1.5	-0.8	-1.2	-1.2	-0.3	0.0	-0.7	0.5	-0.6
Bone: stiffness	1.1	1.7	3.5	-0.1	0.5	-0.8	1.7	1.9	1.6	-1.6	1.2
Tibialis anterior weight	1.4	4.7	7.0	-1.6	-2.3	-1.2	-2.4	-2.4	-2.7	2.2	-2.2
Time to tail flick, vehicle, before self-admin	0.7	0.7	3.2	-0.5	-1.1	-1.8	-0.5	-0.2	-0.5	0.1	-0.5
Time to tail flick, vehicle, after self-admin	2.2	2.9	6.1	2.3	2.5	-0.7	2.1	1.6	1.8	-0.4	1.1
Time to tail flick, test, before self-admin	5.1	5.3	13.5	-3.5	-3.7	-2.5	-1.8	-1.4	-1.8	0.2	-1.4
Time to tail flick, test, after self-admin	0.2	0.2	0.9	0.9	-0.0	-0.1	-0.3	-0.4	-0.3	0.3	0.1
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	4.9	1.9	2.2	-0.1	1.5	1.1	1.4	-0.2	0.8
Delta time to tail flick, test, before/after SA	3.3	3.4	9.8	3.1	2.7	1.9	1.3	1.0	1.4	-0.3	1.3
Tibia length	1.5	4.0	9.4	-1.1	0.1	0.8	2.1	2.5	2.2	-3.1	2.3
Ambulatory time before self-admin	1.7	2.5	10.0	-3.2	-2.7	-0.3	-0.4	0.0	-0.5	-1.4	0.2
Ambulatory time after self-admin	5.5	6.5	16.3	-3.9	-4.0	-2.5	-2.2	-1.5	-2.1	0.1	-1.3
Bone: tissue strength	3.1	3.1	7.4	-2.0	-2.6	-2.7	-1.2	-0.7	-1.5	0.7	-1.6
Total heroin consumption	0.2	0.3	0.5	-0.4	-0.7	0.4	-0.5	-0.5	-0.6	0.4	-0.5
Bone: trabecular number	1.1	1.8	5.0	-2.2	-1.5	-2.2	-1.1	-0.8	-0.8	0.2	-0.2
Bone: trabecular spacing	0.2	0.2	1.5	-0.0	-0.2	1.2	-0.1	-0.3	-0.1	0.1	-0.2
Bone: trabecular thickness	0.1	0.1	0.4	0.6	0.3	-0.2	0.3	0.6	0.2	0.0	0.3
Bone: trabecular tissue density	1.4	2.1	8.8	3.0	2.2	1.1	0.4	-0.2	0.2	1.2	-0.5
Water consumed over 24 hours	0.6	0.8	2.7	-1.6	-0.8	-1.5	0.3	0.3	0.2	-0.5	-0.1
Number of responses in last shaping day	3.3	3.6	8.9	3.0	2.6	2.1	1.9	1.4	1.5	-0.4	1.1