Hub : Genes

Zscan18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative polyA XM_039100661.1 0.52 0.15 0.0e+00 0.09 0.15 0.16 0.16 1.5e-10 5.9e-16 6.5e-18 1.8e-17
2 Liver gene expression Zscan18 0.58 0.15 0.0e+00 0.1 0.16 0.19 0.18 2.8e-11 1.4e-17 1.9e-20 2.1e-19
3 Brain gene expression Zscan18 0.45 0.21 5.9e-03 -0 0.01 0.02 -0 4.4e-01 2.1e-02 2.5e-03 3.8e-01
4 Adipose gene expression Zscan18 0.57 0.14 0.0e+00 0.11 0.18 0.2 0.2 3.4e-12 3.8e-19 3.8e-22 5.6e-22
5 Adipose alternative polyA XM_039100661.1 0.58 0.15 0.0e+00 0.14 0.2 0.22 0.22 1.2e-15 1.4e-21 5.9e-24 6.7e-24
6 Liver alternative polyA XM_008758843.3 0.46 0.15 0.0e+00 0.09 0.12 0.14 0.13 1.1e-09 8.8e-14 3.6e-15 1.2e-14
7 Adipose alternative polyA XM_008758843.3 0.58 0.15 0.0e+00 0.15 0.2 0.22 0.22 5.5e-16 1.1e-21 3.8e-24 4.5e-24
8 Adipose isoform ratio XM_008758843.3 0.45 0.15 0.0e+00 0.11 0.14 0.15 0.15 1.2e-12 5.8e-15 2.9e-16 5.0e-16
9 Brain intron excision ratio chr1_73411736_73421747 0.02 0.02 6.1e-03 0.02 0.01 0.01 0.02 6.9e-03 2.2e-02 2.3e-02 8.6e-03
10 Adipose isoform ratio XR_005498714.1 0.31 0.15 1.1e-10 0.08 0.07 0.07 0.07 8.4e-09 4.0e-08 3.0e-08 3.0e-08
11 NAcc gene expression Zscan18 0.33 0.14 1.8e-14 0.1 0.12 0.12 0.12 7.3e-12 6.1e-14 1.3e-13 2.4e-13
12 BLA gene expression Zscan18 0.3 0.15 6.1e-03 0.03 0.05 0.06 0.03 9.0e-03 7.2e-04 5.4e-04 1.3e-02
13 PL gene expression Zscan18 0.26 0.13 1.5e-06 0.05 0.04 0.04 0.04 6.5e-06 1.3e-05 5.0e-05 2.3e-05
14 pVTA gene expression Zscan18 0.47 0.16 8.0e-06 0.09 0.15 0.16 0.13 1.2e-04 5.1e-07 1.9e-07 2.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.4-0.60.70.60.3-0.60.30.50.40.30.10.2-0.5-0.3-0.4
Area under the delay curve1.92.14.9-1.31.41.31.7-1.21.51.31.2-1.2-1.2-1.62.21.41.2
BMI with tail0.92.85.0-1.21.50.81.1-1.71.61.71.8-1.9-2.0-1.91.92.21.6
BMI without tail1.42.910.2-0.91.11.62.1-0.71.30.90.9-1.1-1.1-1.92.72.03.2
Body weight0.20.81.81.3-1.2-0.7-1.01.2-1.0-1.1-1.10.60.60.40.30.20.6
Weight adjusted by age0.30.41.1-0.1-0.20.50.20.5-0.3-0.6-0.71.11.00.7-0.1-0.8-0.2
Bone surface2.23.87.21.3-1.5-0.6-1.61.8-1.9-1.9-2.02.72.42.4-2.2-2.3-2.0
Bone volume1.93.25.51.4-1.4-0.8-1.61.6-1.8-1.7-1.72.32.12.2-2.0-2.0-1.8
Breakpoint value in progressive ratio session2.62.811.2-0.10.70.81.4-0.51.00.80.8-1.5-1.6-2.23.42.32.8
Number of licking bursts0.40.41.20.7-0.9-1.1-0.70.8-0.5-0.8-0.70.40.30.20.40.20.6
Context. condit. distance diff. score0.70.82.2-1.11.21.51.2-1.10.91.00.9-0.6-0.5-0.5-0.3-0.3-0.2
Locomotion velocity, session 10.30.30.9-0.70.41.0-0.0-0.10.30.1-0.10.80.50.3-0.4-0.9-0.5
Locomotion distance, session 11.21.65.2-0.2-0.60.3-0.71.2-0.6-1.2-1.42.31.91.5-1.1-1.7-0.3
Locomotion velocity, session 20.10.20.4-0.60.40.6-0.3-0.30.30.20.20.50.20.3-0.6-0.5-0.2
Locomotion distance, session 21.62.34.70.7-1.3-0.7-1.51.6-1.3-1.6-1.72.21.91.8-1.6-1.6-0.8
Locomotion velocity, session 30.10.10.70.2-0.1-0.0-0.4-0.0-0.2-0.0-0.00.00.10.3-0.8-0.4-0.5
Locomotion distance, session 30.80.92.5-1.01.11.60.8-0.90.40.70.60.30.30.5-1.6-1.2-1.2
Stereotopy head waving bouts, day 30.20.30.70.2-0.6-0.7-0.50.60.0-0.4-0.3-0.2-0.2-0.40.80.50.8
Stereotopy head waving duration, day 30.50.61.20.8-1.1-1.1-0.81.0-0.4-0.9-0.80.00.0-0.21.00.50.8
Locomotion velocity, session 70.30.30.50.6-0.5-0.4-0.50.6-0.7-0.6-0.70.70.70.6-0.4-0.6-0.3
Locomotion distance, session 70.00.00.1-0.10.00.40.20.10.0-0.1-0.10.10.20.10.2-0.10.0
Stereotopy head waving bouts, day 70.50.62.20.6-0.5-0.4-0.90.4-0.7-0.5-0.40.50.50.8-1.5-1.0-1.3
Stereotopy head waving duration, day 70.40.50.80.8-0.7-0.6-0.90.6-0.8-0.6-0.60.60.50.7-0.9-0.7-0.8
Locomotion velocity, session 80.10.10.4-0.50.20.40.3-0.00.30.0-0.00.30.30.1-0.3-0.40.6
Locomotion distance, session 80.20.31.1-0.60.51.00.3-0.30.20.20.10.60.40.4-1.0-1.0-0.5
Degree of sensitization distance0.50.51.90.6-0.7-0.7-0.40.8-0.3-0.6-0.60.10.1-0.31.40.70.9
Degree of sensitization stereotypy0.50.63.2-0.40.50.4-0.2-0.60.10.50.40.10.00.5-1.8-0.9-1.6
Conditioned locomotion0.20.31.1-1.10.40.60.5-0.20.80.20.20.1-0.0-0.30.40.10.9
Cocaine response after cond. corrected0.80.93.01.7-1.2-1.5-1.60.6-1.0-0.6-0.2-0.6-0.60.1-0.40.6-0.9
Cocaine response after cond. not corrected1.61.83.92.0-1.7-1.5-1.71.4-1.7-1.4-1.20.70.71.1-1.0-0.5-1.3
Cocaine response before conditioning1.82.25.90.2-0.70.40.11.3-1.1-1.4-1.62.42.41.9-1.3-2.2-0.8
Saline control response0.40.51.6-1.20.81.10.5-0.50.60.40.30.70.50.4-0.7-0.60.3
Bone: connectivity density0.40.71.7-1.31.21.00.7-1.20.91.01.0-0.1-0.4-0.2-0.6-0.1-0.4
Bone: cortical apparent density0.81.02.91.7-1.4-1.7-1.01.2-1.1-1.0-0.90.10.20.10.70.50.1
Bone: cortical area0.20.31.1-0.10.11.1-0.20.3-0.2-0.3-0.41.00.80.50.1-0.40.5
Bone: cortical porosity0.20.30.80.00.30.4-0.3-0.60.30.60.7-0.9-0.9-0.60.00.3-0.3
Bone: cortical porosity0.10.20.40.30.10.4-0.5-0.30.00.30.4-0.7-0.6-0.3-0.20.1-0.5
Bone: cortical thickness0.81.33.1-0.81.01.10.7-0.91.00.90.9-0.7-0.9-1.21.71.31.8
Bone: cortical thickness0.10.20.40.6-0.30.2-0.20.4-0.6-0.4-0.50.60.50.30.1-0.2-0.2
Bone: cortical tissue density0.81.13.21.8-1.5-1.8-1.11.2-1.2-1.1-1.00.10.20.20.60.5-0.0
Condit. Reinf. active minus inactive responses0.30.30.90.9-0.8-1.0-0.80.7-0.5-0.6-0.50.10.00.00.40.20.2
Condit. Reinf. active-inactive response ratio0.70.71.5-0.30.60.20.3-0.70.70.80.9-1.0-1.1-1.11.21.20.9
Condit. Reinf. active responses1.01.21.81.3-1.4-1.2-1.31.2-1.2-1.2-1.10.80.80.9-0.7-0.8-0.8
Condit. Reinf. inactive responses2.63.14.51.5-1.7-1.0-1.31.8-1.8-1.9-1.91.91.91.9-2.0-2.1-1.7
Incentive salience index mean0.40.51.00.8-0.9-0.7-0.71.0-0.7-0.9-0.90.70.60.50.0-0.30.1
Condit. Reinf. lever presses0.30.51.00.4-0.7-0.2-0.21.0-0.6-0.9-1.00.91.00.6-0.0-0.50.3
Condit. Reinf. active minus inactive responses2.22.75.70.9-1.2-0.3-1.11.6-1.5-1.6-1.82.42.32.2-1.7-2.1-1.1
Condit. Reinf. active-inactive response ratio3.53.75.21.6-1.7-1.4-1.71.9-2.0-1.9-2.12.22.32.3-1.7-2.1-1.8
Condit. Reinf. active responses1.31.85.10.3-0.60.5-0.11.1-1.0-1.2-1.42.22.11.8-1.3-1.9-0.5
Condit. Reinf. inactive responses0.50.62.0-1.00.91.41.4-0.40.70.40.30.20.2-0.30.3-0.01.2
Condit. Reinf. lever presses0.30.31.5-0.90.81.20.5-0.60.60.50.40.20.0-0.0-0.1-0.10.4
Condit. Reinf. lever reinforcers received1.62.26.00.3-0.60.5-0.31.2-1.1-1.3-1.52.52.32.0-1.7-2.2-0.9
Conditioned reinforcement - actives2.32.36.82.6-2.1-2.1-1.81.9-1.9-1.7-1.50.50.50.6-0.2-0.00.1
Conditioned reinforcement - inactives4.24.78.72.4-2.6-1.3-1.22.9-2.5-2.8-2.92.62.61.8-0.6-1.7-0.2
Conditioned locomotion2.73.38.12.8-2.5-2.5-2.12.3-2.1-2.1-1.90.90.90.9-0.1-0.4-0.2
Patch foraging indifference point 0 sec1.82.95.1-2.01.92.31.9-1.61.91.61.5-0.9-1.1-1.61.91.02.1
Patch foraging indifference point AUC0.40.50.9-0.90.70.20.2-0.90.90.80.9-0.8-0.9-0.6-0.00.60.2
Delay disc. indifference point, 0s delay3.13.49.1-3.02.52.82.7-2.02.21.91.6-0.4-0.4-0.90.70.30.8
Delay disc. indifference point, 16s delay0.80.82.71.3-1.0-1.6-1.20.5-0.6-0.4-0.2-0.8-0.7-0.40.90.6-1.0
Delay disc. indifference point, 2s delay0.80.92.2-0.70.91.11.5-0.60.80.70.7-0.7-0.6-0.91.20.91.1
Delay disc. indifference point, 24s delay0.30.30.80.5-0.5-0.9-0.40.2-0.0-0.20.0-0.8-0.7-0.50.80.80.0
Delay disc. indifference point, 4s delay0.00.00.1-0.00.10.20.2-0.0-0.0-0.0-0.00.10.20.10.20.2-0.1
Delay disc. indifference point, 8s delay1.41.54.1-1.21.11.21.4-0.91.31.00.9-0.7-0.8-1.42.01.01.4
Indifference point function ln k3.04.29.41.3-1.7-0.1-0.32.6-1.9-2.5-2.73.13.02.2-1.1-2.3-0.2
Indifference point function log k3.04.29.41.3-1.7-0.1-0.32.6-1.9-2.5-2.73.13.02.2-1.1-2.3-0.2
Patch foraging total patch changes 0 sec1.82.94.9-1.81.92.21.9-1.51.81.61.4-0.9-1.1-1.72.11.12.2
Patch foraging total patch changes 12 sec0.91.21.9-1.41.10.60.5-1.31.41.31.3-1.2-1.2-1.00.50.90.8
Patch foraging total patch changes 18 sec1.52.03.3-1.81.61.01.0-1.71.71.61.6-1.3-1.3-1.31.11.11.1
Patch foraging total patch changes 24 sec0.30.41.60.3-0.1-0.9-1.1-0.4-0.10.40.4-0.5-0.50.1-0.5-0.1-1.3
Patch foraging total patch changes 6 sec0.60.91.6-0.60.70.40.2-0.90.90.91.0-1.1-1.3-1.21.21.21.1
Patch foraging time to switch 0 sec1.31.97.11.6-1.0-2.7-2.0-0.1-0.50.20.6-2.0-1.9-0.80.21.6-0.8
Patch foraging water rate 0 sec0.40.62.2-1.20.81.51.1-0.20.50.2-0.10.90.90.3-0.2-0.80.2
Patch foraging water rate 12 sec0.81.23.2-1.00.31.81.50.70.2-0.7-0.91.71.70.50.3-1.11.2
Patch foraging water rate 18 sec0.30.41.4-0.10.11.00.90.5-0.1-0.4-0.61.00.90.20.3-0.41.2
Patch foraging water rate 24 sec0.30.41.2-0.40.10.90.40.3-0.1-0.3-0.51.11.00.6-0.4-1.1-0.3
Patch foraging water rate 6 sec4.46.410.41.5-2.3-1.0-1.72.8-2.3-2.8-2.93.23.23.0-2.6-3.0-1.8
Seeking ratio, delayed vs. immediate footshock3.64.110.0-3.22.63.23.0-2.02.41.91.7-0.6-0.5-1.10.60.31.9
Distance traveled before self-admin1.01.14.8-1.20.92.22.0-0.10.50.1-0.21.11.20.2-0.1-1.10.6
Distance traveled after self-admin4.95.416.2-3.63.24.03.7-2.32.62.21.9-0.3-0.4-1.10.2-0.51.0
Extensor digitorum longus weight0.00.10.40.2-0.2-0.2-0.20.4-0.3-0.4-0.40.70.50.4-0.2-0.30.1
Bone: elastic displacement0.91.02.2-0.81.01.21.1-0.71.00.80.8-0.7-0.8-1.21.50.81.4
Bone: elastic work0.50.62.4-0.70.81.61.2-0.30.50.30.20.40.2-0.41.00.11.2
Bone: endosteal estimation2.04.57.61.5-1.40.1-1.51.7-2.1-1.8-1.92.52.52.6-2.7-2.8-2.7
Bone: endosteal perimeter1.12.44.40.9-1.10.3-1.01.5-1.4-1.6-1.72.12.11.9-1.6-2.0-1.3
Epididymis fat weight0.30.61.90.6-0.4-1.4-1.1-0.1-0.00.10.2-1.0-0.9-0.71.11.20.5
Delta time in closed arm before/after self-admin0.30.30.6-0.80.60.20.3-0.70.60.70.6-0.4-0.4-0.30.00.40.3
Delta time in open arm before/after self-admin0.60.61.50.5-0.60.40.21.0-0.6-0.9-1.01.01.00.5-0.1-1.2-0.5
Diff in mean of infusions in LGA sessions2.02.26.4-1.41.42.22.2-0.81.30.90.7-0.3-0.3-1.32.11.02.5
Delay discount exponential model param1.71.85.01.2-1.2-1.2-1.61.0-1.4-1.1-1.11.11.11.5-2.2-1.4-1.2
Extinction: sum of active levers before priming2.22.25.0-2.21.92.22.2-1.41.71.41.2-0.5-0.4-1.01.10.30.9
Active lever presses in extinction session 61.00.93.11.5-1.2-1.8-1.60.7-0.9-0.7-0.5-0.3-0.50.2-0.50.1-0.9
Bone: final force1.11.83.41.1-1.2-0.4-1.11.4-1.4-1.4-1.51.81.71.6-1.1-1.4-1.3
Bone: final moment1.22.04.11.0-1.0-0.0-1.01.3-1.4-1.4-1.52.01.91.7-1.3-1.7-1.3
Food consumed during 24 hour testing period0.81.01.91.1-1.1-0.5-0.81.4-1.0-1.3-1.31.41.20.70.5-0.30.6
Glucose1.21.83.2-1.31.41.31.3-1.31.41.31.3-1.0-1.1-1.31.61.31.8
Heart weight0.81.12.30.5-0.80.40.51.5-0.7-1.4-1.51.41.50.60.8-0.41.2
Delay discount hyperbolic model param1.41.53.81.1-1.2-1.2-1.60.9-1.2-1.0-1.00.90.91.3-1.9-1.2-1.1
Intermittent access intake day 1-15 change1.81.84.01.7-1.8-0.8-0.72.0-1.5-1.9-1.91.41.40.80.2-0.60.4
Intermittent access intake escalation2.52.45.02.2-2.2-1.4-1.22.2-1.8-2.1-2.01.31.30.90.2-0.50.1
Intermittent access intake escalation 21.11.12.21.3-1.3-0.5-0.51.5-1.2-1.4-1.41.21.20.7-0.2-0.60.2
Intermitt. access day 1 inactive lever presses8.89.516.64.1-4.0-3.6-3.53.7-3.5-3.6-3.32.12.12.2-1.8-2.1-1.9
Intermitt. access day 15 inactive lever presses8.28.913.53.7-3.6-3.5-3.53.4-3.3-3.3-3.12.12.12.5-2.3-2.2-2.3
Intermitt. access escalation Index1.21.14.2-0.60.60.30.9-0.70.90.80.8-1.0-1.0-1.32.01.41.0
Intermittent access day 1 total infusions0.50.60.90.9-0.9-0.9-0.90.8-0.9-0.8-0.80.60.60.8-0.9-0.6-0.3
Intermittent access day 15 total infusions3.84.39.53.1-2.9-2.2-1.82.8-2.5-2.6-2.51.51.51.10.3-0.50.2
Intermittent access terminal intake (last 3 days)3.13.47.12.7-2.5-1.9-1.82.4-2.2-2.3-2.21.41.41.2-0.5-0.60.0
Intermittent access total infusions2.93.26.22.5-2.4-1.9-1.82.3-2.1-2.2-2.11.41.41.3-0.7-0.9-0.2
Intermittent access day 1 locomotion1.11.12.01.4-1.4-1.1-0.81.4-1.3-1.3-1.31.01.00.8-0.3-0.60.1
Intermittent access day 15 total locomotion1.82.04.42.0-1.9-1.0-0.52.1-1.5-1.9-1.91.11.10.30.9-0.11.3
Intermittent access total locomotion2.63.05.32.2-2.3-1.8-1.42.3-2.0-2.2-2.21.51.51.2-0.6-0.80.1
Intermittent access standard deviation2.02.15.82.4-2.1-2.4-2.01.7-1.6-1.6-1.30.20.20.40.00.2-0.3
Left kidney weight2.26.310.22.3-2.5-1.1-1.53.0-2.7-3.0-3.13.23.22.7-1.8-2.5-1.0
Right kidney weight2.15.810.02.7-2.8-1.5-1.63.2-2.8-3.1-3.12.72.82.2-1.0-1.9-0.6
Cocaine induced anxiety1.01.12.70.3-0.60.2-0.11.0-0.8-1.1-1.21.61.61.2-0.8-1.5-0.8
Post-drug Anxiety1.71.94.21.6-1.4-1.6-1.81.1-1.5-1.1-1.00.70.71.3-1.7-1.2-2.1
Baseline Anxiety0.91.03.51.4-0.9-1.9-1.80.2-0.8-0.20.1-0.8-0.80.1-0.90.3-1.1
Tail length0.41.34.60.2-0.61.11.11.4-0.5-1.2-1.41.41.50.30.9-0.32.2
Length with tail1.55.48.42.3-2.6-1.2-1.92.8-2.6-2.8-2.92.62.72.5-1.7-2.0-0.8
Length without tail1.83.97.01.8-2.0-1.9-2.61.7-2.0-1.7-1.71.61.62.1-2.2-1.6-2.4
Times rat made contact with spout0.60.71.7-1.30.80.41.3-0.81.10.80.8-0.8-0.5-0.60.30.50.7
Lifetime Intake1.31.53.01.7-1.6-1.3-1.21.6-1.5-1.5-1.40.90.90.8-0.3-0.40.2
Liver weight, left1.01.64.31.8-1.5-2.1-2.10.9-1.4-0.9-0.7-0.10.00.7-1.0-0.3-1.7
Liver weight, right0.20.31.70.7-0.8-0.7-1.30.4-0.5-0.4-0.3-0.2-0.10.2-0.30.1-0.5
Locomotor activity0.30.50.9-0.50.80.60.9-0.90.60.90.8-0.9-0.8-0.80.50.60.7
Locomotor testing distance0.10.10.30.10.40.10.5-0.50.00.50.5-0.5-0.4-0.3-0.00.1-0.1
Locomotor testing rearing0.10.20.8-0.00.20.00.2-0.1-0.30.1-0.00.20.40.4-0.8-0.9-0.8
Locomotion in novel chamber1.82.23.4-1.61.71.11.9-1.71.71.61.7-1.6-1.5-1.51.10.90.3
Locomotion in novel chamber post-restriction1.61.93.5-1.91.51.51.0-1.61.71.61.5-1.0-1.1-1.21.31.21.0
Fecal boli incidents, locomotor time 10.10.10.3-0.1-0.10.60.40.0-0.1-0.0-0.20.50.40.10.4-0.30.1
Change in fecal boli incidents, locomotor task4.13.94.8-1.72.01.62.0-2.11.92.22.1-2.0-2.0-2.11.92.21.9
Time >=10cm from walls, locomotor time 10.20.20.50.2-0.3-0.7-0.6-0.00.10.10.1-0.3-0.5-0.50.60.40.1
Bouts of movement, locomotor time 11.51.65.0-1.91.22.22.1-0.81.30.70.50.30.3-0.71.20.21.6
Total resting periods, locomotor time 10.91.02.8-1.40.91.71.6-0.81.00.80.6-0.1-0.1-0.71.20.51.2
Rest time, locomotor task time 11.51.73.21.1-1.8-0.6-1.20.9-1.6-1.1-1.31.51.41.4-0.8-1.1-1.8
Distance moved, locomotor task time 10.60.61.3-0.81.20.50.8-0.61.00.70.8-1.0-0.9-0.90.50.50.6
Vertical activity count, locomotor time 14.74.98.3-2.52.82.62.9-2.02.52.12.0-1.7-1.6-2.22.01.32.3
Time >=10cm from walls, locomotor time 20.40.41.1-0.20.4-0.5-0.3-0.70.50.70.8-1.0-1.0-0.60.10.8-0.2
Bouts of movement, locomotor time 20.10.10.6-0.80.60.10.1-0.50.60.40.4-0.1-0.2-0.1-0.10.1-0.0
Total resting periods, locomotor time 20.30.41.5-1.20.90.50.4-0.80.80.70.6-0.1-0.2-0.2-0.00.20.1
Rest time, locomotor task time 21.21.33.7-1.91.61.61.4-1.41.31.31.1-0.2-0.3-0.50.50.40.8
Distance moved, locomotor task time 20.00.10.2-0.20.40.20.2-0.10.30.10.2-0.3-0.10.0-0.4-0.2-0.2
Vertical activity count, locomotor time 21.01.12.3-1.41.51.51.5-1.01.31.00.9-0.6-0.5-0.90.60.31.0
Light reinforcement 10.61.24.2-1.51.42.11.8-0.91.10.90.8-0.0-0.1-0.40.00.01.0
Light reinforcement 20.40.61.2-0.10.70.40.6-0.80.50.80.9-1.0-1.0-0.90.71.10.6
Bone: marrow area2.14.57.71.4-1.40.1-1.51.7-2.1-1.8-1.92.52.52.6-2.7-2.8-2.8
Bone: maximum diameter0.30.62.00.3-0.50.6-0.50.8-0.6-0.8-0.91.41.20.9-0.3-0.80.3
Bone: maximum force1.01.83.61.2-1.1-0.2-1.01.4-1.5-1.4-1.51.91.81.6-1.0-1.4-1.0
Bone: maximum moment1.11.94.31.0-1.00.1-0.81.3-1.4-1.4-1.52.11.91.7-1.1-1.6-1.0
Mean time between licks in bursts1.31.92.8-1.11.61.61.7-1.51.31.51.4-1.3-1.3-1.51.31.10.7
Mean num. licks in bursts0.70.92.0-1.21.21.11.4-1.21.01.11.0-0.8-0.5-0.5-0.30.0-0.2
Cd content in liver0.30.31.1-0.50.30.91.00.10.2-0.1-0.20.50.6-0.00.70.00.8
Co content in liver0.80.91.91.0-1.2-1.4-0.71.3-1.0-1.2-1.20.90.90.60.2-0.00.4
Cu content in liver1.51.83.31.2-1.4-1.6-1.31.3-1.3-1.3-1.21.11.11.3-1.5-1.3-1.8
Fe content in liver0.30.30.70.8-0.7-0.6-0.80.6-0.7-0.6-0.60.40.40.4-0.1-0.10.1
K content in liver0.10.10.5-0.1-0.00.10.30.0-0.1-0.1-0.10.10.20.2-0.5-0.6-0.7
Mg content in liver0.10.10.3-0.10.1-0.10.1-0.20.20.20.3-0.5-0.4-0.3-0.1-0.1-0.5
Mn content in liver0.10.20.60.20.1-0.00.5-0.30.10.30.4-0.8-0.6-0.60.40.3-0.2
Na content in liver1.01.12.2-1.11.00.80.7-1.31.21.31.3-1.5-1.3-1.10.20.5-0.1
Rb content in liver0.40.52.30.4-0.30.1-0.40.2-0.5-0.3-0.30.20.40.7-1.4-1.2-1.5
Se content in liver1.51.83.1-0.91.30.41.0-1.51.41.51.6-1.7-1.8-1.71.21.31.0
Sr content in liver12.211.214.3-3.53.83.43.6-3.53.63.53.4-2.7-2.8-3.33.32.83.3
Zn content in liver0.40.52.00.9-0.9-1.4-1.40.5-0.6-0.5-0.3-0.1-0.20.2-0.20.2-0.6
Bone: minimum diameter1.32.56.10.4-0.70.8-0.71.2-1.2-1.3-1.52.52.22.1-1.9-2.3-1.4
Time in familiar zone, hab. session 10.90.82.4-0.70.41.51.00.2-0.1-0.3-0.61.51.40.9-0.3-1.3-0.4
Time in novel zone, hab. session 10.80.83.01.3-0.8-1.7-1.50.2-0.6-0.10.1-1.0-0.9-0.2-0.20.7-0.3
Total zone transitions, hab. session 10.71.03.0-0.40.10.7-0.00.2-0.3-0.3-0.51.41.21.3-1.7-1.7-1.5
Total locomotion distance, hab. session 10.50.72.6-1.61.01.61.1-0.60.90.50.40.60.40.0-0.1-0.60.1
Locomotion velocity, hab. session 10.30.41.6-1.30.71.20.8-0.40.70.40.20.60.30.1-0.2-0.6-0.1
Time in familiar zone, hab. session 22.52.63.21.7-1.8-1.4-1.61.8-1.8-1.8-1.81.51.61.7-1.3-1.4-1.6
Time in novel zone, hab. session 20.70.71.2-0.60.80.30.5-1.00.81.01.0-1.1-1.1-0.90.30.80.7
Total zone transitions, hab. session 20.91.23.6-1.00.31.3-0.10.20.1-0.3-0.51.71.41.2-1.5-1.9-0.8
Total locomotion distance, hab. session 21.01.44.1-2.01.62.01.4-1.11.51.10.90.1-0.2-0.60.60.00.9
Locomotion velocity, hab. session 21.41.85.2-2.21.82.31.6-1.31.71.31.10.0-0.3-0.80.70.11.1
Novel to familiar place preference ratio0.60.61.5-0.91.01.11.2-0.80.80.70.7-0.3-0.3-0.50.50.20.6
Novelty place preference0.20.20.8-0.50.60.80.9-0.40.40.30.30.00.0-0.20.2-0.10.3
Time in novel zone, NPP test0.10.10.5-0.40.40.60.7-0.20.20.20.20.10.1-0.00.1-0.10.2
Total zone transitions, NPP test0.20.20.8-0.90.60.90.2-0.40.50.30.20.60.20.0-0.0-0.30.4
Total locomotion distance, NPP test0.60.82.1-1.51.01.30.8-0.71.10.70.50.2-0.2-0.60.90.31.2
Locomotion velocity, NPP test0.60.92.8-1.71.21.51.0-0.71.20.70.60.3-0.1-0.50.80.11.2
Intraocular pressure0.20.30.70.5-0.5-0.8-0.70.4-0.5-0.4-0.40.40.40.6-0.8-0.5-0.6
Delta distance traveled before/after self-admin2.32.43.9-2.02.01.81.8-1.81.91.81.7-1.2-1.3-1.40.70.71.0
Delta ambulatory time before/after self-admin2.12.33.3-1.81.81.71.8-1.61.71.61.5-1.2-1.3-1.41.20.91.2
Parametrial fat weight3.87.412.1-1.82.10.81.8-2.62.62.72.9-3.4-3.3-3.33.33.52.5
Pavlov. Cond. lever latency0.10.10.40.6-0.2-0.3-0.40.2-0.5-0.2-0.20.10.10.10.10.0-0.4
Pavlov. Cond. magazine entry latency0.70.91.3-1.11.00.60.9-1.11.11.11.1-1.1-1.1-1.00.50.90.5
Pavlov. Cond. change in total contacts0.30.40.9-0.90.60.50.8-0.50.80.50.5-0.4-0.4-0.50.40.40.7
Pavlov. Cond. index score0.50.71.2-1.10.80.71.0-0.81.00.80.8-0.8-0.7-0.80.50.60.7
Pavlov. Cond. latency score0.50.71.3-1.10.80.61.0-0.81.10.80.8-0.7-0.7-0.80.60.70.9
Pavlov. Cond. lever contacts0.00.00.1-0.3-0.1-0.10.10.10.2-0.1-0.0-0.1-0.0-0.1-0.2-0.10.3
Pavlov. Cond. magazine entry number0.70.91.81.4-1.2-0.9-1.11.2-1.2-1.1-1.10.80.80.8-0.2-0.5-0.5
Pavlov. Cond. intertrial magazine entries0.10.10.60.00.20.80.40.1-0.1-0.1-0.10.60.40.2-0.0-0.50.1
Pavlov. Cond. lever-magazine prob. diff.0.40.50.9-0.90.70.50.9-0.70.90.70.7-0.8-0.7-0.70.50.60.7
Pavlov. Cond. response bias0.10.10.3-0.60.30.00.2-0.40.50.40.4-0.5-0.4-0.3-0.30.1-0.0
Pavlov. Cond. lever latency4.05.49.62.7-2.9-3.1-2.82.6-2.6-2.5-2.41.61.72.0-1.5-1.4-1.9
Pavlov. Cond. magazine entry latency2.32.73.1-1.61.71.61.5-1.71.81.81.7-1.6-1.6-1.61.41.61.5
Pavlov. Cond. change in total contacts1.01.44.7-1.71.62.21.8-1.11.21.10.90.0-0.1-0.40.2-0.10.8
Pavlov. Cond. index score2.02.54.9-1.92.02.21.9-1.81.81.81.7-1.1-1.2-1.30.90.91.2
Pavlov. Cond. latency score2.53.15.1-2.02.12.32.0-1.92.01.91.8-1.3-1.4-1.61.31.21.5
Pavlov. Cond. lever contacts1.92.76.0-2.22.12.52.0-1.91.91.81.7-0.9-1.0-1.10.60.61.0
Pavlov. Cond. magazine entry number1.21.52.41.3-1.5-1.6-1.21.4-1.3-1.4-1.41.01.11.1-0.8-1.0-0.8
Pavlov. Cond. intertrial magazine entries4.25.57.81.8-2.1-1.6-1.92.3-2.3-2.3-2.42.62.62.6-2.6-2.8-2.6
Pavlov. Cond. lever-magazine prob. diff.1.72.14.5-1.81.92.11.8-1.61.61.61.5-0.9-1.0-1.20.80.81.1
Pavlov. Cond. response bias0.91.34.1-1.61.62.01.4-1.31.21.21.1-0.3-0.4-0.4-0.10.00.3
Time in closed arm before self-admin1.72.04.52.1-1.9-1.3-1.41.9-1.7-1.8-1.71.00.90.8-0.1-0.4-0.0
Time in closed arm after self-admin0.50.51.41.2-1.0-1.1-1.10.8-0.8-0.7-0.60.20.10.4-0.3-0.1-0.3
Time in open arm before self-admin2.42.76.0-2.52.21.51.5-2.31.92.12.0-1.2-1.1-0.80.00.80.4
Time in open arm after self-admin1.01.13.1-1.81.41.41.2-1.31.31.21.1-0.4-0.4-0.50.10.1-0.1
Bone: periosteal estimation1.12.34.80.8-0.80.8-1.11.2-1.4-1.3-1.42.22.02.0-1.7-2.0-1.5
Bone: periosteal perimeter1.01.73.40.4-0.70.4-0.71.0-1.1-1.1-1.21.81.81.8-1.6-1.8-1.3
Bone: post-yield work2.23.04.21.9-1.6-1.6-1.71.5-2.1-1.6-1.61.61.61.9-1.9-1.5-1.9
Progressive ratio test 1 active lever presses0.50.52.1-0.3-0.00.50.20.3-0.3-0.4-0.51.11.10.9-0.9-1.5-0.8
Progressive ratio test 1 breakpoint0.50.51.9-0.2-0.10.50.20.3-0.3-0.4-0.51.01.00.8-0.9-1.4-0.7
Progressive ratio test 1 inactive lever presses4.24.56.31.8-2.2-1.3-1.72.3-2.2-2.4-2.42.32.32.2-2.2-2.5-1.6
Progressive ratio test 2 active lever presses2.02.14.52.1-2.0-1.3-1.12.0-1.8-1.9-1.91.31.30.9-0.2-0.50.4
Progressive ratio test 2 breakpoint2.62.95.72.4-2.3-1.6-1.42.3-2.1-2.2-2.11.51.51.1-0.4-0.80.1
Progressive ratio test 2 inactive lever presses3.94.67.82.6-2.6-1.6-1.62.8-2.4-2.7-2.72.22.21.8-1.2-1.7-0.3
Incentive Sensitization - Responses7.88.014.93.9-3.8-3.0-2.73.6-3.4-3.5-3.42.32.32.0-0.9-1.3-0.8
Incentive Sensitization - Breakpoint6.76.813.73.7-3.6-2.9-2.63.3-3.1-3.2-3.01.91.91.8-0.8-1.1-0.8
Sum of active levers in priming session hrs 5-61.21.15.5-0.30.51.21.5-0.00.60.20.1-0.2-0.2-1.22.30.91.8
Progressive ratio2.63.17.2-2.72.52.41.8-2.12.12.01.8-0.8-0.9-1.10.60.50.9
Food seeking constrained by brief footshock14.417.845.7-6.15.56.86.5-3.94.73.83.2-0.9-0.9-2.52.71.03.8
Seeking ratio, punishment vs. effort0.70.94.3-1.10.91.72.1-0.30.70.30.10.40.5-0.30.90.11.2
Retroperitoneal fat weight4.013.220.8-2.32.91.42.3-3.63.43.73.8-4.6-4.4-4.44.54.53.2
Reaction time number correct1.72.55.7-2.42.12.21.8-1.81.91.81.6-0.8-0.9-1.10.60.40.4
Reaction time mean minus median0.30.31.40.6-0.7-1.2-0.80.5-0.5-0.5-0.40.10.20.5-0.60.1-0.4
Reaction time mean minus median AUC0.30.31.30.4-0.5-1.1-0.90.2-0.4-0.2-0.2-0.00.00.5-0.9-0.2-1.0
Reaction time num false alarms0.10.10.7-0.00.10.10.5-0.10.20.20.0-0.2-0.1-0.50.80.20.8
Reaction time num false alarms AUC0.81.12.1-1.01.11.11.5-1.01.11.10.9-0.7-0.6-1.11.30.51.2
Reaction time trials correct on left1.72.55.7-2.42.12.21.8-1.81.91.81.6-0.8-0.9-1.10.60.40.4
Reaction time trials on left1.62.45.4-2.32.02.21.8-1.81.91.71.6-0.8-0.9-1.10.60.40.4
Reaction time mean3.04.27.72.6-2.7-2.8-2.52.4-2.3-2.3-2.11.21.31.6-1.7-1.1-1.1
Reaction time mean AUC2.33.16.92.4-2.4-2.6-2.22.0-2.0-1.9-1.70.70.81.2-1.3-0.7-0.8
Median of all reaction times2.43.35.92.3-2.4-2.4-2.12.2-2.0-2.1-2.01.11.21.4-1.5-1.0-0.7
Reaction time omissions0.00.10.40.10.1-0.10.2-0.20.00.20.1-0.3-0.2-0.30.70.10.2
Reaction time false alarm rate0.10.21.00.3-0.1-0.30.30.1-0.0-0.0-0.1-0.2-0.1-0.41.00.30.9
Reaction time premature initiation rate0.10.10.70.1-0.3-0.8-0.20.2-0.0-0.2-0.2-0.1-0.1-0.20.40.50.8
Reaction time premature initiations0.50.71.1-1.10.90.30.8-0.81.00.80.8-0.6-0.6-0.80.90.91.0
Std. dev. reaction times1.41.94.01.8-1.9-2.0-1.71.6-1.5-1.5-1.40.70.81.0-1.0-0.6-0.7
Reaction time trials completed1.62.45.4-2.32.02.21.8-1.81.91.71.6-0.8-0.9-1.10.60.40.4
Reaction time trials AUC1.52.25.2-2.32.02.01.7-1.81.81.71.5-0.8-0.9-1.10.70.40.4
Run reversals in cocaine runway, females1.00.92.71.6-1.2-1.1-1.41.2-1.1-1.0-1.00.50.30.10.9-0.10.1
Run reversals in cocaine runway, males0.40.30.90.6-0.5-0.7-0.80.3-0.6-0.4-0.30.30.30.7-0.9-0.3-0.9
Latency to leave start box in cocaine runway1.11.12.31.4-1.4-1.0-0.41.5-1.1-1.4-1.40.80.90.41.20.3-0.1
Latency to leave start box in cocaine runway, F0.50.52.80.7-0.8-0.40.30.9-0.5-0.8-0.80.30.4-0.11.70.70.5
Latency to leave start box in cocaine runway, M1.51.42.01.4-1.4-1.3-1.21.3-1.4-1.3-1.31.01.01.1-0.7-0.7-1.1
Std. dev. time between licks in bursts0.20.31.5-0.50.51.20.6-0.10.30.10.00.50.2-0.20.80.10.6
Total sessions with >9 infusions3.23.64.32.0-2.0-1.7-1.82.0-2.0-2.0-1.91.71.71.8-2.1-2.0-1.7
Short access day 1 total inactive lever presses3.23.67.22.6-2.5-2.7-2.62.1-2.2-2.0-1.81.01.01.5-1.1-0.8-1.1
Short access day 10 total inactive lever presses2.62.85.22.3-2.2-2.1-2.12.0-1.9-1.9-1.81.11.11.3-1.1-0.7-0.8
Short access day 1 total infusions0.00.00.1-0.30.10.10.1-0.00.1-0.0-0.00.20.20.3-0.2-0.3-0.2
Short access day 10 total infusions0.40.41.11.0-0.9-1.0-1.00.6-0.8-0.6-0.50.10.10.4-0.5-0.2-0.4
Short access total infusions0.40.51.2-0.60.70.70.7-0.60.70.70.6-0.6-0.6-0.70.70.71.1
Short access day 1 locomotion1.51.62.71.4-1.2-1.5-1.41.2-1.4-1.2-1.11.01.01.3-1.6-1.2-1.1
Short access day 10 total locomotion1.01.22.61.2-1.2-0.7-0.51.6-1.1-1.5-1.51.21.20.7-0.1-0.90.4
Short access total locomotion0.30.31.6-0.50.50.81.0-0.10.40.20.10.00.0-0.50.50.11.3
One hour access (0.3 mA shock)6.47.412.53.5-3.5-2.7-2.63.5-3.2-3.4-3.32.32.32.2-1.5-1.6-0.5
Compulsive drug intake1.41.42.41.0-1.4-0.8-0.91.5-1.1-1.5-1.51.31.31.1-0.8-1.1-0.5
One hour access (shock baseline)4.75.413.03.6-3.1-3.2-2.92.7-2.8-2.5-2.31.21.21.5-1.1-0.6-0.8
Social response proportion3.13.46.52.3-2.6-2.2-2.12.5-2.0-2.4-2.21.41.31.2-0.3-0.5-0.3
Social responses5.06.49.42.7-3.1-2.3-2.53.1-2.8-3.0-2.92.32.42.5-2.0-1.8-1.5
Social time1.11.54.6-0.2-0.50.90.51.2-0.6-1.2-1.52.12.11.3-0.4-1.70.1
Soleus weight0.10.41.6-0.40.40.70.7-0.20.40.30.2-0.0-0.1-0.51.00.71.3
Bone: stiffness2.13.34.21.9-2.0-1.2-1.82.0-2.0-2.1-2.12.01.92.0-1.4-1.5-1.2
Tibialis anterior weight1.75.97.1-2.22.62.12.3-2.62.52.72.6-2.3-2.4-2.62.42.42.3
Time to tail flick, vehicle, before self-admin0.20.20.60.3-0.4-0.4-0.20.6-0.5-0.6-0.60.70.80.5-0.3-0.50.3
Time to tail flick, vehicle, after self-admin3.73.98.02.8-2.6-2.6-2.32.4-2.3-2.3-2.21.31.31.4-0.5-0.7-0.9
Time to tail flick, test, before self-admin3.43.312.0-2.92.13.53.0-1.21.91.10.70.50.5-0.71.4-0.31.7
Time to tail flick, test, after self-admin0.00.00.20.2-0.2-0.3-0.30.2-0.1-0.2-0.20.00.00.1-0.2-0.4-0.1
Delta time to tail flick, vehicle, before/after SA1.31.33.31.8-1.6-1.8-1.61.3-1.3-1.2-1.00.30.20.50.30.2-0.8
Delta time to tail flick, test, before/after SA2.42.27.02.3-1.8-2.7-2.41.2-1.5-1.2-0.9-0.1-0.10.7-1.2-0.3-1.2
Tibia length1.85.110.21.1-1.6-0.1-1.62.1-1.9-2.2-2.43.22.92.8-2.6-3.1-1.9
Ambulatory time before self-admin0.80.82.9-1.20.71.71.5-0.10.50.1-0.21.01.00.4-0.6-1.3-0.1
Ambulatory time after self-admin3.13.412.7-2.82.43.63.3-1.41.91.41.00.30.2-0.70.4-0.81.0
Bone: tissue strength1.91.85.8-1.61.41.71.7-0.81.40.90.7-0.1-0.3-1.11.90.92.4
Total heroin consumption1.72.02.9-1.51.41.31.5-1.31.61.41.4-1.3-1.3-1.51.71.41.4
Bone: trabecular number0.91.43.5-1.91.71.51.2-1.51.41.41.3-0.3-0.5-0.4-0.10.30.3
Bone: trabecular spacing0.10.20.4-0.40.40.60.4-0.50.40.50.5-0.5-0.4-0.40.30.2-0.0
Bone: trabecular thickness0.20.20.80.8-0.4-0.9-0.50.3-0.6-0.3-0.30.20.10.2-0.00.1-0.3
Bone: trabecular tissue density0.91.24.41.8-1.2-2.1-1.60.5-0.8-0.4-0.1-1.1-1.0-0.50.51.2-0.2
Water consumed over 24 hours0.40.51.50.2-0.40.10.20.8-0.5-0.8-0.91.21.20.70.1-0.30.8
Number of responses in last shaping day2.32.45.32.3-2.1-2.0-1.91.8-1.8-1.7-1.50.80.81.0-0.6-0.6-1.2