Zscan18

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Zscan18	0.37	0.19	5.1e-03	0.01	0.01	0.02	0.01	3.5e-02	3.3e-02	3.6e-03	9.0e-02
2	IC	gene expression	Zscan18	0.4	0.2	9.3e-04	0.05	0.05	0.03	0.02	5.4e-03	4.1e-03	2.5e-02	3.6e-02
3	pVTA	gene expression	Zscan18	0.44	0.14	6.9e-11	0	0.13	0.14	0.13	1.3e-01	2.1e-10	3.5e-11	2.2e-10
4	Liver	gene expression	Zscan18	0.61	0.15	0.0e+00	0.14	0.19	0.21	0.2	9.9e-15	6.1e-21	4.2e-23	3.9e-22
5	Adipose	gene expression	Zscan18	0.67	0.13	0.0e+00	0.17	0.25	0.27	0.28	3.4e-18	2.9e-27	9.0e-30	1.2e-30
6	NAcc	gene expression	Zscan18	0.42	0.13	0.0e+00	0.13	0.16	0.15	0.15	2.2e-19	4.0e-24	1.6e-22	1.1e-21
7	Brain	intron excision ratio	chr1_82483925_82493934	0.02	0.02	6.5e-03	0.01	0	0	0	7.8e-02	1.9e-01	2.8e-01	1.9e-01
8	PL	gene expression	Zscan18	0.27	0.13	2.2e-06	0.04	0.05	0.05	0.04	2.6e-05	6.8e-06	3.2e-06	6.8e-05
9	RMTg	gene expression	Zscan18	0.28	0.17	9.7e-03	0.07	0.01	0.04	0.06	6.5e-03	1.6e-01	3.3e-02	9.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.3	0.6	2.6	1.1	-0.8	1.6	0.2	0.2	-0.1	0.4	-0.3	-0.8
Area under the delay curve	0.7	1.1	1.7	0.3	-1.2	0.2	1.1	-1.1	-1.3	-1.2	1.1	1.1
BMI with tail	0.4	1.6	3.1	-0.0	-0.7	1.0	1.2	-1.4	-1.5	-1.8	1.6	1.2
BMI without tail	0.0	0.2	0.8	-0.9	-0.0	0.5	-0.2	0.3	-0.3	-0.5	0.7	0.3
Body weight	0.5	2.1	5.2	-0.8	0.9	-0.6	-2.1	2.3	1.6	1.3	-0.8	-1.5
Weight adjusted by age	0.1	0.4	1.3	1.1	-1.1	0.5	-0.0	0.3	-0.0	0.8	-0.2	-0.6
Bone surface	2.0	3.9	8.4	0.4	0.6	-0.4	-2.0	2.4	2.1	2.5	-2.4	-2.9
Bone volume	1.7	3.4	7.4	0.1	0.7	0.1	-2.0	2.4	2.0	2.2	-2.1	-2.7
Breakpoint value in progressive ratio session	0.5	0.9	2.2	-1.3	0.2	-0.7	0.2	-0.5	-0.8	-1.3	1.1	1.5
Number of licking bursts	0.1	0.4	1.6	-0.9	0.5	-1.2	-0.6	0.3	0.2	-0.2	0.1	0.1
Context. condit. distance diff. score	0.5	0.6	2.2	1.5	-1.0	0.5	0.8	-0.8	-0.6	0.3	-0.2	0.0
Locomotion velocity, session 1	0.6	0.7	2.7	1.2	-1.1	-1.6	0.2	0.2	-0.1	0.8	-0.3	-0.2
Locomotion distance, session 1	0.9	1.1	3.0	1.2	-0.8	0.0	-0.7	1.3	0.9	1.7	-0.8	-1.1
Locomotion velocity, session 2	0.2	0.2	1.2	1.1	-0.7	0.3	0.3	-0.1	-0.1	0.4	-0.3	-0.2
Locomotion distance, session 2	1.1	1.5	3.0	0.2	0.3	0.5	-1.3	1.7	1.4	1.6	-1.4	-1.4
Locomotion velocity, session 3	0.1	0.1	0.3	-0.0	0.3	0.0	-0.2	0.2	0.3	0.4	-0.6	-0.3
Locomotion distance, session 3	1.2	1.4	5.7	2.4	-1.3	1.1	0.5	-0.1	-0.0	1.2	-1.0	-1.2
Stereotopy head waving bouts, day 3	0.8	0.9	3.3	-1.6	0.8	-1.8	-0.3	0.0	0.1	-0.5	0.6	0.9
Stereotopy head waving duration, day 3	0.8	1.0	3.4	-1.9	0.9	-1.6	-0.3	0.1	0.1	-0.5	0.7	1.2
Locomotion velocity, session 7	0.2	0.3	0.8	-0.1	0.3	0.9	-0.4	0.6	0.5	0.6	-0.5	-0.3
Locomotion distance, session 7	0.1	0.1	0.8	0.4	-0.3	0.9	0.0	0.2	0.0	0.2	-0.0	-0.3
Stereotopy head waving bouts, day 7	0.7	0.8	2.0	-0.3	1.0	-1.4	-0.6	0.4	0.9	0.9	-1.1	-0.5
Stereotopy head waving duration, day 7	0.3	0.4	1.0	-0.4	0.7	-1.0	-0.5	0.4	0.6	0.6	-0.7	-0.3
Locomotion velocity, session 8	0.2	0.3	1.5	0.8	-0.6	1.2	0.2	-0.1	-0.2	0.3	-0.1	-0.1
Locomotion distance, session 8	0.4	0.6	2.3	1.5	-0.9	0.7	0.3	0.1	-0.0	1.0	-0.7	-0.6
Degree of sensitization distance	0.4	0.5	1.7	-1.3	0.5	-0.7	-0.3	0.2	-0.0	-0.6	0.8	0.8
Degree of sensitization stereotypy	0.5	0.5	1.5	1.0	0.2	-0.7	0.0	-0.1	0.4	0.9	-1.2	-0.9
Conditioned locomotion	0.3	0.3	0.7	0.8	-0.8	0.8	0.5	-0.1	-0.5	-0.1	0.5	0.4
Cocaine response after cond. corrected	1.4	2.2	7.1	-2.4	2.7	-2.1	-0.7	-0.2	0.7	-0.7	-0.2	0.7
Cocaine response after cond. not corrected	1.2	1.8	4.8	-1.8	2.2	-1.6	-1.4	0.9	1.4	0.4	-0.9	-0.4
Cocaine response before conditioning	2.0	2.5	4.9	1.7	-1.2	1.0	-1.1	1.8	1.2	2.2	-1.2	-2.2
Saline control response	0.8	1.1	4.1	1.7	-1.0	2.0	0.2	0.2	0.1	0.8	-0.5	-0.9
Bone: connectivity density	0.4	0.6	2.3	1.5	-1.0	0.9	0.8	-0.3	-0.5	0.2	-0.4	-0.4
Bone: cortical apparent density	0.3	0.5	2.4	-1.5	0.4	0.5	-0.6	0.8	0.1	-0.5	0.4	0.3
Bone: cortical area	0.5	0.9	2.7	1.1	-1.4	1.6	-0.1	0.9	0.0	0.7	-0.1	-0.9
Bone: cortical porosity	0.2	0.2	0.5	-0.0	0.3	0.2	0.5	-0.7	-0.3	-0.4	0.3	0.6
Bone: cortical porosity	0.1	0.2	0.7	-0.6	0.8	-0.4	-0.1	-0.1	0.2	-0.1	-0.2	0.3
Bone: cortical thickness	0.9	1.6	5.1	0.4	-1.4	2.3	0.9	-0.5	-1.3	-1.1	1.4	0.8
Bone: cortical thickness	0.1	0.1	0.4	-0.1	-0.1	0.4	-0.4	0.6	0.2	0.3	-0.3	-0.5
Bone: cortical tissue density	0.3	0.5	2.7	-1.6	0.5	0.3	-0.7	0.8	0.2	-0.5	0.3	0.2
Condit. Reinf. active minus inactive responses	0.5	0.5	2.6	-1.6	1.1	-0.5	-0.6	0.3	0.4	-0.3	-0.0	0.3
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.5	-0.4	0.0	0.8	0.7	-1.0	-0.9	-1.2	1.0	1.1
Condit. Reinf. active responses	1.0	1.3	2.4	-1.6	1.5	-1.1	-1.3	1.0	1.1	0.7	-1.0	-0.6
Condit. Reinf. inactive responses	2.1	2.7	4.3	-0.5	1.0	-1.5	-1.8	1.9	1.8	2.1	-2.0	-1.7
Incentive salience index mean	0.3	0.4	1.1	-1.0	0.8	-0.2	-0.8	0.6	0.6	0.3	-0.3	-0.3
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.2	0.1	0.2	-0.8	0.8	0.6	0.6	-0.3	-0.7
Condit. Reinf. active minus inactive responses	1.3	2.0	4.5	0.8	-0.1	-0.3	-1.4	1.7	1.5	2.0	-1.5	-2.1
Condit. Reinf. active-inactive response ratio	1.8	2.8	5.3	-0.2	0.5	-1.3	-1.7	2.3	1.8	2.1	-1.8	-2.0
Condit. Reinf. active responses	1.3	1.9	4.7	1.7	-0.9	0.7	-0.9	1.2	1.0	1.8	-1.0	-2.2
Condit. Reinf. inactive responses	0.8	1.2	3.8	1.8	-1.5	1.9	0.6	-0.7	-0.7	-0.1	0.6	-0.5
Condit. Reinf. lever presses	0.5	0.7	2.1	1.5	-1.1	1.4	0.6	-0.4	-0.5	0.1	0.3	-0.4
Condit. Reinf. lever reinforcers received	1.8	2.5	6.4	1.9	-0.8	0.7	-1.1	1.5	1.2	2.2	-1.4	-2.5
Conditioned reinforcement - actives	0.5	1.9	6.4	-2.5	2.1	-1.1	-1.3	1.3	1.2	0.4	-0.7	0.1
Conditioned reinforcement - inactives	0.6	1.6	3.7	-0.9	0.6	-1.1	-1.7	1.9	1.2	1.3	-1.0	-0.9
Conditioned locomotion	0.8	1.2	5.0	-2.2	1.4	-1.4	-0.8	0.7	0.6	0.0	-0.3	0.3
Patch foraging indifference point 0 sec	0.8	2.3	6.2	1.4	-2.5	0.8	1.7	-1.4	-2.0	-0.9	1.3	1.2
Patch foraging indifference point AUC	0.1	0.3	0.8	-0.6	0.4	-0.1	0.6	-0.6	-0.3	-0.6	0.3	0.9
Delay disc. indifference point, 0s delay	3.4	3.8	10.4	3.2	-3.0	2.7	1.7	-1.2	-1.4	-0.1	0.9	0.0
Delay disc. indifference point, 16s delay	2.2	3.1	12.8	-3.6	1.9	-3.1	-0.5	-0.0	0.2	-0.9	-0.3	1.0
Delay disc. indifference point, 2s delay	0.8	0.9	1.4	0.9	-1.0	0.7	0.9	-1.1	-1.0	-0.8	1.2	0.7
Delay disc. indifference point, 24s delay	0.7	1.1	4.0	-2.0	1.2	-1.4	-0.2	-0.4	-0.1	-0.9	0.3	1.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.5	-0.2	0.5	-0.2	0.1	0.1	-0.2	0.2	-0.3
Delay disc. indifference point, 8s delay	0.9	1.5	3.0	0.6	-1.7	0.5	1.4	-1.0	-1.6	-1.1	1.3	1.4
Indifference point function ln k	0.9	2.7	5.8	1.2	-0.4	0.4	-1.9	2.1	1.6	2.4	-1.3	-2.2
Indifference point function log k	0.9	2.7	5.8	1.2	-0.4	0.4	-1.9	2.1	1.6	2.4	-1.3	-2.2
Patch foraging total patch changes 0 sec	0.8	2.3	6.1	1.2	-2.5	0.8	1.6	-1.3	-2.0	-1.0	1.4	1.1
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	0.0	-0.2	0.3	0.7	-0.8	-0.6	-0.7	0.4	0.7
Patch foraging total patch changes 18 sec	0.5	1.1	1.6	0.8	-1.3	0.4	1.3	-1.2	-1.3	-0.9	0.9	1.0
Patch foraging total patch changes 24 sec	0.4	1.3	4.9	-1.6	1.2	-2.2	-0.5	0.7	0.7	0.4	-1.2	-0.4
Patch foraging total patch changes 6 sec	0.6	1.0	1.8	-0.3	-0.4	0.1	1.1	-1.3	-1.2	-1.3	1.3	1.3
Patch foraging time to switch 0 sec	1.2	4.7	18.5	-4.3	3.8	-2.0	-0.6	-0.3	0.6	-1.6	-0.2	1.2
Patch foraging water rate 0 sec	0.5	1.7	7.4	2.7	-2.2	1.3	0.6	-0.0	-0.5	0.7	0.3	-0.5
Patch foraging water rate 12 sec	0.8	3.0	12.9	3.6	-2.6	2.4	0.3	0.2	-0.3	0.9	0.7	-0.6
Patch foraging water rate 18 sec	0.5	1.0	4.2	2.0	-1.7	1.1	0.4	0.2	-0.4	0.4	0.7	-0.2
Patch foraging water rate 24 sec	0.4	0.6	1.8	1.4	-1.0	-0.6	-0.2	0.5	0.2	1.2	-0.4	-0.8
Patch foraging water rate 6 sec	3.5	5.1	8.5	0.7	0.8	-1.4	-2.6	2.8	2.6	2.9	-2.4	-2.7
Seeking ratio, delayed vs. immediate footshock	4.4	6.3	20.2	4.5	-3.6	3.3	2.1	-1.5	-1.8	-0.2	1.6	0.1
Distance traveled before self-admin	1.5	3.3	12.3	3.4	-3.5	1.5	0.7	-0.2	-1.0	1.0	0.6	-0.6
Distance traveled after self-admin	4.9	8.6	21.5	4.6	-4.6	3.0	2.9	-2.3	-2.8	-0.5	1.7	0.9
Extensor digitorum longus weight	0.1	0.3	0.6	0.3	-0.2	0.5	-0.6	0.7	0.3	0.5	-0.4	-0.8
Bone: elastic displacement	1.2	1.5	2.2	0.4	-1.4	-1.5	1.2	-1.1	-1.4	-0.9	1.1	1.5
Bone: elastic work	0.6	0.8	3.8	1.4	-1.9	0.4	0.7	-0.2	-0.9	0.0	0.6	0.0
Bone: endosteal estimation	1.7	4.2	8.6	0.8	0.9	-1.0	-1.8	1.8	2.4	2.9	-2.6	-2.8
Bone: endosteal perimeter	0.8	1.9	4.5	0.8	-0.1	-0.6	-1.1	1.5	1.4	2.1	-1.7	-1.9
Epididymis fat weight	0.2	1.1	3.4	-1.9	1.9	-1.0	-0.9	0.8	0.8	-0.3	-0.1	-0.2
Delta time in closed arm before/after self-admin	0.7	0.6	4.3	0.5	-0.5	2.1	0.5	-0.4	-0.2	-0.2	0.3	-0.1
Delta time in open arm before/after self-admin	1.3	1.5	5.5	-1.1	0.4	-2.3	-1.0	1.2	0.8	1.3	-1.2	-0.5
Diff in mean of infusions in LGA sessions	0.7	1.2	2.8	1.3	-1.7	1.4	0.8	-0.5	-1.1	-0.6	1.2	0.7
Delay discount exponential model param	0.7	0.9	1.5	-0.3	1.1	-0.2	-1.0	1.0	1.2	1.1	-1.1	-1.1
Extinction: sum of active levers before priming	0.1	0.1	0.4	0.3	-0.6	0.1	0.3	-0.4	-0.2	0.3	-0.6	-0.2
Active lever presses in extinction session 6	2.2	2.2	7.0	-2.6	2.6	-1.4	-1.1	0.8	1.2	-0.2	-0.7	-0.2
Bone: final force	0.9	1.5	3.6	0.6	-0.3	0.8	-1.3	1.6	1.2	1.5	-1.0	-1.9
Bone: final moment	1.2	2.0	4.6	1.0	-0.6	0.8	-1.3	1.8	1.2	1.8	-1.2	-2.1
Food consumed during 24 hour testing period	0.2	0.3	1.1	-0.4	-0.1	0.8	-0.8	1.0	0.4	0.3	0.2	-0.4
Glucose	2.5	3.9	6.9	0.9	-1.6	2.6	1.9	-2.0	-2.0	-2.1	2.4	1.8
Heart weight	0.5	0.9	1.9	-1.4	0.9	1.2	-1.3	1.1	0.9	0.1	0.2	-0.3
Delay discount hyperbolic model param	1.0	1.3	2.0	-0.6	1.4	-0.5	-1.1	1.2	1.4	1.2	-1.3	-1.2
Intermittent access intake day 1-15 change	0.3	1.6	3.0	-1.7	1.4	-1.3	-1.7	1.5	1.1	0.6	-0.7	-0.4
Intermittent access intake escalation	0.6	3.0	5.6	-2.4	2.0	-2.1	-2.2	1.9	1.6	0.9	-1.0	-0.6
Intermittent access intake escalation 2	0.2	0.3	1.4	0.5	-0.5	1.2	-0.2	0.3	-0.2	-0.3	0.6	0.2
Intermitt. access day 1 inactive lever presses	0.5	6.8	17.1	-4.1	2.8	-3.9	-2.4	2.3	1.9	1.5	-2.0	-0.4
Intermitt. access day 15 inactive lever presses	1.1	5.7	8.5	-2.9	2.7	-2.7	-2.3	2.4	2.3	2.0	-2.5	-1.2
Intermitt. access escalation Index	0.2	0.7	1.4	-1.2	-0.1	-0.6	0.3	-0.6	-0.7	-1.0	1.2	1.0
Intermittent access day 1 total infusions	0.4	1.2	2.2	-1.2	1.3	-1.5	-0.9	1.0	1.1	0.8	-1.1	-0.5
Intermittent access day 15 total infusions	2.0	4.8	12.7	-3.6	2.7	-3.2	-2.2	2.0	1.7	0.7	-1.1	-0.1
Intermittent access terminal intake (last 3 days)	1.4	2.4	4.5	-2.1	2.1	-1.9	-1.7	1.7	1.4	0.6	-0.9	-0.2
Intermittent access total infusions	3.0	3.6	6.1	-2.5	2.3	-2.5	-2.0	1.9	1.7	1.2	-1.6	-0.6
Intermittent access day 1 locomotion	1.1	2.1	4.4	-2.1	1.6	-1.4	-1.6	1.6	1.4	1.0	-1.1	-0.7
Intermittent access day 15 total locomotion	0.1	0.4	1.3	-0.8	-0.2	-0.6	-0.8	1.1	0.3	0.6	0.2	0.1
Intermittent access total locomotion	2.6	3.1	5.5	-2.0	1.7	-1.5	-2.2	2.3	1.9	1.6	-1.3	-1.1
Intermittent access standard deviation	0.1	0.6	1.9	-0.4	-0.2	-0.1	0.5	-0.5	-0.9	-1.0	1.1	1.4
Left kidney weight	1.3	10.8	21.5	-0.5	1.5	-0.5	-4.0	4.6	3.7	4.2	-3.4	-3.7
Right kidney weight	1.7	12.0	23.8	-1.6	2.2	-1.1	-4.4	4.9	3.9	4.1	-3.5	-3.5
Cocaine induced anxiety	0.6	1.5	2.1	-0.9	0.9	-1.2	-1.4	1.4	1.3	1.3	-1.3	-1.1
Post-drug Anxiety	2.4	2.7	4.2	-1.8	2.0	-1.3	-1.6	1.5	1.8	1.3	-2.0	-1.2
Baseline Anxiety	0.2	0.4	1.4	0.3	-0.2	1.2	0.7	-0.8	-0.5	-0.6	0.3	0.4
Tail length	0.9	5.1	10.6	-0.6	1.0	-0.9	-3.0	3.3	2.5	2.9	-2.0	-2.3
Length with tail	2.0	8.7	15.8	-1.2	2.3	-1.9	-3.8	4.0	3.4	3.2	-2.7	-2.9
Length without tail	1.6	8.6	12.8	-2.7	3.6	-2.8	-3.5	3.4	3.4	2.0	-2.4	-2.1
Times rat made contact with spout	0.5	0.6	1.8	1.0	-0.7	1.4	0.7	-0.7	-0.6	-0.5	0.4	0.2
Lifetime Intake	2.1	2.6	4.3	-2.1	2.0	-2.0	-1.7	1.6	1.5	1.0	-1.3	-0.6
Liver weight, left	0.8	1.3	2.6	-0.7	0.7	-0.8	-1.6	1.6	1.2	1.2	-0.8	-1.2
Liver weight, right	0.3	0.5	1.0	0.7	-1.0	1.0	0.4	-0.3	-0.7	-0.4	1.0	0.1
Locomotor activity	0.3	0.4	0.8	0.5	-0.6	0.9	0.6	-0.7	-0.8	-0.6	0.4	0.4
Locomotor testing distance	0.0	0.1	0.4	-0.3	0.6	-0.1	-0.3	0.0	0.2	-0.1	-0.4	-0.2
Locomotor testing rearing	0.1	0.2	0.7	0.7	-0.1	0.0	-0.2	0.3	0.3	0.8	-0.8	-0.5
Locomotion in novel chamber	0.7	0.9	4.3	0.3	-0.5	-2.1	0.8	-1.1	-0.8	-0.8	0.1	0.5
Locomotion in novel chamber post-restriction	0.3	1.0	1.3	1.0	-0.9	0.6	1.0	-1.1	-1.1	-1.1	1.1	1.0
Fecal boli incidents, locomotor time 1	0.2	0.5	2.0	1.0	-0.9	1.4	0.3	0.1	-0.3	-0.0	0.3	0.2
Change in fecal boli incidents, locomotor task	2.5	2.6	4.9	0.5	-0.9	2.2	1.6	-1.8	-1.6	-1.9	1.9	1.4
Time >=10cm from walls, locomotor time 1	0.3	0.4	1.9	-1.4	0.8	-0.4	-0.4	0.4	0.1	-0.2	-0.3	0.2
Bouts of movement, locomotor time 1	2.6	3.4	8.8	2.9	-2.9	3.0	1.3	-0.7	-1.3	-0.3	1.3	0.1
Total resting periods, locomotor time 1	2.0	2.3	7.5	2.1	-2.0	2.7	1.1	-0.7	-1.1	-0.6	1.2	0.2
Rest time, locomotor task time 1	0.6	0.9	3.2	0.5	0.2	1.8	-0.9	1.1	0.9	0.4	-0.2	-1.4
Distance moved, locomotor task time 1	0.4	1.0	3.7	-0.4	-0.4	-1.9	1.0	-1.2	-1.0	-0.4	0.2	1.2
Vertical activity count, locomotor time 1	0.7	5.0	9.7	1.9	-3.1	0.8	2.8	-2.6	-2.9	-1.2	1.7	2.0
Time >=10cm from walls, locomotor time 2	0.1	0.3	1.1	-1.1	1.0	-0.5	-0.1	-0.2	0.1	-0.6	-0.3	0.4
Bouts of movement, locomotor time 2	0.0	0.1	0.4	0.5	-0.4	0.1	-0.0	-0.0	-0.1	-0.1	-0.1	-0.6
Total resting periods, locomotor time 2	0.1	0.2	0.9	0.9	-0.6	0.5	0.1	0.0	-0.1	-0.1	0.1	-0.8
Rest time, locomotor task time 2	1.0	1.6	5.6	2.4	-1.9	1.9	0.9	-0.5	-0.8	-0.2	0.6	-0.4
Distance moved, locomotor task time 2	0.2	0.2	1.4	-0.0	-0.0	-1.2	0.3	-0.5	-0.2	0.2	-0.3	0.3
Vertical activity count, locomotor time 2	0.5	1.1	2.6	1.6	-1.5	0.5	1.2	-1.1	-1.1	-0.3	0.6	0.6
Light reinforcement 1	0.3	1.5	6.2	2.5	-1.8	1.1	0.7	-1.1	-0.8	0.0	0.7	-0.3
Light reinforcement 2	0.2	0.5	1.1	-0.2	-0.1	-0.2	0.5	-0.9	-0.7	-1.0	1.0	0.7
Bone: marrow area	1.7	4.2	8.6	0.9	0.9	-1.0	-1.8	1.8	2.4	2.9	-2.6	-2.8
Bone: maximum diameter	0.3	0.7	1.4	0.8	-1.0	1.2	-0.3	1.1	0.3	1.0	-0.6	-0.9
Bone: maximum force	0.8	1.6	4.1	1.0	-0.7	1.1	-1.2	1.5	1.0	1.5	-0.9	-2.0
Bone: maximum moment	1.1	2.0	4.9	1.4	-1.0	1.1	-1.1	1.6	1.0	1.8	-1.1	-2.2
Mean time between licks in bursts	0.2	1.3	2.2	0.9	-1.2	0.8	1.1	-1.2	-1.3	-1.2	1.5	0.8
Mean num. licks in bursts	0.4	1.1	5.7	1.5	-0.8	2.4	0.8	-0.6	-0.5	-0.0	0.1	-0.1
Cd content in liver	0.9	1.0	2.1	-0.6	0.8	-1.0	-0.9	1.4	1.3	1.1	-0.8	-0.9
Co content in liver	0.6	0.7	2.4	-0.6	0.8	0.4	-1.0	1.5	1.1	0.5	-0.4	-0.5
Cu content in liver	3.6	4.3	6.6	-1.9	2.2	-2.6	-2.1	2.0	2.2	1.8	-2.0	-1.6
Fe content in liver	1.9	2.4	4.4	-2.1	1.8	-1.9	-1.7	1.6	1.4	0.7	-1.2	-0.7
K content in liver	0.3	0.3	1.1	-0.5	0.4	-1.0	-0.0	0.4	0.5	0.7	-0.7	-0.1
Mg content in liver	0.7	0.8	2.1	-1.2	1.3	-1.4	-0.4	0.5	0.6	0.4	-0.9	0.2
Mn content in liver	0.5	0.5	1.6	-1.3	1.0	-1.2	-0.4	0.0	0.4	0.3	-0.7	0.1
Na content in liver	0.4	0.4	1.2	-0.4	0.5	-0.6	0.8	-1.1	-0.5	-0.4	0.0	0.9
Rb content in liver	4.1	4.8	8.1	-0.9	2.2	-2.8	-2.1	1.8	2.5	2.5	-2.4	-1.8
Se content in liver	1.0	1.2	2.6	-0.3	-0.2	-0.7	1.2	-1.6	-1.3	-1.2	0.9	1.5
Sr content in liver	11.1	9.6	12.6	2.5	-3.4	3.1	3.4	-3.3	-3.6	-2.7	3.1	2.6
Zn content in liver	1.5	1.8	5.6	-2.4	2.1	-2.2	-0.5	0.4	0.7	-0.3	-0.5	0.4
Bone: minimum diameter	1.3	2.5	5.5	1.9	-1.1	0.4	-0.9	1.6	1.2	2.3	-1.6	-2.2
Time in familiar zone, hab. session 1	1.5	1.7	6.4	2.5	-1.9	0.5	-0.1	0.5	0.2	1.3	-0.1	-1.6
Time in novel zone, hab. session 1	1.4	1.5	6.7	-2.6	2.1	-0.9	-0.4	0.1	0.3	-0.8	-0.4	1.0
Total zone transitions, hab. session 1	1.1	1.5	3.4	1.9	-0.7	1.0	-0.4	0.8	0.8	1.8	-1.2	-1.5
Total locomotion distance, hab. session 1	0.9	1.3	5.4	2.3	-2.0	0.9	0.9	-0.3	-0.6	0.5	0.1	-0.3
Locomotion velocity, hab. session 1	0.5	0.7	3.1	1.8	-1.5	0.3	0.6	-0.1	-0.5	0.6	-0.1	-0.2
Time in familiar zone, hab. session 2	2.4	2.7	5.1	-1.1	1.3	-2.3	-1.8	1.7	1.7	1.4	-1.5	-1.7
Time in novel zone, hab. session 2	0.6	0.7	2.3	0.0	-0.0	1.5	0.8	-0.9	-0.7	-0.8	0.5	1.0
Total zone transitions, hab. session 2	1.4	1.8	5.8	2.4	-1.5	0.9	-0.0	0.8	0.4	1.9	-1.0	-1.1
Total locomotion distance, hab. session 2	1.8	2.3	7.4	2.5	-2.7	1.0	1.6	-0.8	-1.5	-0.0	0.7	0.6
Locomotion velocity, hab. session 2	2.2	2.9	8.7	2.8	-3.0	1.2	1.8	-1.0	-1.7	-0.1	0.9	0.8
Novel to familiar place preference ratio	0.5	0.6	1.8	1.3	-1.1	0.6	0.8	-0.8	-0.7	-0.2	0.7	0.3
Novelty place preference	0.2	0.3	1.2	1.1	-0.7	0.4	0.3	-0.4	-0.2	0.1	0.3	-0.0
Time in novel zone, NPP test	0.1	0.2	0.8	0.9	-0.5	0.3	0.2	-0.3	-0.1	0.2	0.2	-0.1
Total zone transitions, NPP test	0.4	0.6	1.9	1.4	-1.2	1.3	0.4	-0.1	-0.4	0.3	0.2	-0.2
Total locomotion distance, NPP test	0.9	1.2	4.1	1.5	-2.0	0.7	1.2	-0.5	-1.2	-0.3	0.9	0.7
Locomotion velocity, NPP test	1.0	1.5	5.0	1.8	-2.2	0.8	1.2	-0.5	-1.2	-0.1	0.8	0.6
Intraocular pressure	0.2	0.3	0.5	-0.4	0.6	0.3	-0.6	0.4	0.5	0.4	-0.7	-0.5
Delta distance traveled before/after self-admin	1.7	1.9	3.1	0.7	-1.1	0.9	1.7	-1.7	-1.7	-1.4	1.1	1.6
Delta ambulatory time before/after self-admin	1.2	2.1	2.8	0.6	-1.2	1.4	1.6	-1.6	-1.7	-1.5	1.5	1.6
Parametrial fat weight	1.9	4.5	7.1	0.2	-1.7	1.1	2.2	-2.1	-2.6	-2.7	2.5	2.6
Pavlov. Cond. lever latency	0.0	0.1	0.4	-0.2	0.2	-0.6	-0.1	0.1	0.1	0.0	-0.2	-0.0
Pavlov. Cond. magazine entry latency	0.7	0.9	1.3	0.4	-0.6	1.0	1.2	-1.1	-1.1	-1.1	0.8	1.0
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	0.5	-0.5	0.9	0.7	-0.6	-0.6	-0.4	0.5	0.5
Pavlov. Cond. index score	0.4	0.5	0.8	0.5	-0.6	0.9	0.9	-0.8	-0.8	-0.6	0.6	0.6
Pavlov. Cond. latency score	0.5	0.6	0.9	0.5	-0.7	0.9	0.9	-0.8	-0.9	-0.7	0.8	0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	0.2	0.2	-0.0	-0.0	0.0	0.0	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.5	0.7	1.7	-0.9	0.7	-1.3	-1.0	0.8	0.8	0.5	-0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.7	0.8	-0.8	-0.1	0.1	-0.0	-0.1	0.5	-0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	0.4	-0.6	0.7	0.8	-0.8	-0.8	-0.7	0.6	0.7
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	0.0	0.5	0.4	-0.4	-0.2	-0.1	-0.1	0.1
Pavlov. Cond. lever latency	2.9	4.1	7.4	-2.7	2.6	-1.9	-2.3	2.2	2.2	1.1	-1.6	-1.0
Pavlov. Cond. magazine entry latency	1.6	2.3	3.1	1.1	-1.3	1.3	1.8	-1.7	-1.8	-1.5	1.5	1.5
Pavlov. Cond. change in total contacts	0.8	2.0	6.0	2.5	-2.2	1.8	1.2	-0.9	-1.1	0.1	0.5	-0.2
Pavlov. Cond. index score	1.4	2.1	4.1	2.0	-1.9	1.3	1.7	-1.6	-1.6	-0.7	1.1	0.6
Pavlov. Cond. latency score	1.7	2.8	4.0	1.8	-2.0	1.4	2.0	-1.9	-1.9	-1.2	1.5	1.1
Pavlov. Cond. lever contacts	2.3	3.4	7.2	2.7	-2.5	1.9	2.0	-1.9	-1.8	-0.8	1.4	0.7
Pavlov. Cond. magazine entry number	1.0	1.3	1.9	-1.1	1.1	-0.9	-1.3	1.4	1.3	1.0	-1.0	-0.8
Pavlov. Cond. intertrial magazine entries	2.2	4.8	6.9	-0.5	1.2	-2.6	-2.4	2.2	2.5	2.6	-2.3	-2.5
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.1	3.7	1.9	-1.9	1.1	1.7	-1.6	-1.6	-0.8	1.1	0.7
Pavlov. Cond. response bias	1.5	2.0	6.5	2.6	-2.1	1.5	1.4	-1.3	-1.2	-0.1	0.7	-0.1
Time in closed arm before self-admin	0.3	0.5	1.2	-0.7	0.7	-0.9	-1.1	1.1	0.6	0.3	0.2	0.0
Time in closed arm after self-admin	0.3	0.3	0.7	-0.7	0.9	-0.0	-0.7	0.6	0.6	0.2	-0.3	-0.3
Time in open arm before self-admin	2.1	2.5	5.3	1.9	-1.5	2.3	1.8	-1.8	-1.4	-1.2	1.1	0.5
Time in open arm after self-admin	0.3	0.3	0.7	0.6	-0.8	-0.6	0.8	-0.7	-0.5	0.1	-0.1	0.1
Bone: periosteal estimation	1.0	2.4	5.2	1.4	-0.5	0.5	-1.1	1.7	1.4	2.3	-1.8	-2.3
Bone: periosteal perimeter	1.1	2.2	5.3	1.3	-0.5	0.1	-1.1	1.6	1.3	2.0	-1.7	-2.3
Bone: post-yield work	2.0	3.4	5.6	-0.5	1.7	-0.2	-2.1	2.0	2.3	2.0	-2.1	-2.4
Progressive ratio test 1 active lever presses	0.2	0.4	1.0	0.7	-0.6	0.0	-0.2	0.5	0.3	1.0	-0.7	-0.7
Progressive ratio test 1 breakpoint	0.2	0.3	0.9	0.6	-0.7	0.1	-0.2	0.5	0.2	1.0	-0.7	-0.6
Progressive ratio test 1 inactive lever presses	1.5	3.8	5.2	-1.9	1.6	-1.8	-2.1	2.3	2.0	2.1	-2.1	-1.4
Progressive ratio test 2 active lever presses	1.7	2.4	6.5	-2.5	2.1	-1.9	-1.6	1.4	1.3	0.3	-0.9	0.0
Progressive ratio test 2 breakpoint	2.2	2.8	7.0	-2.7	2.3	-2.1	-1.7	1.6	1.4	0.4	-1.1	-0.1
Progressive ratio test 2 inactive lever presses	1.3	4.1	6.5	-1.9	1.8	-1.7	-2.3	2.6	2.1	2.2	-2.1	-1.3
Incentive Sensitization - Responses	1.9	5.1	14.0	-3.7	3.1	-2.2	-2.5	2.3	2.0	0.5	-1.2	-0.3
Incentive Sensitization - Breakpoint	2.0	4.6	12.9	-3.6	3.1	-2.2	-2.3	2.1	1.9	0.4	-1.0	-0.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	0.2	-1.0	-0.3	0.3	-0.4	-0.9	-0.6	1.0	0.8
Progressive ratio	0.7	2.0	5.7	2.4	-1.9	2.3	1.4	-0.6	-0.9	-0.3	0.6	0.1
Food seeking constrained by brief footshock	21.5	26.9	72.6	8.5	-8.1	6.7	4.3	-3.1	-4.2	-1.0	3.5	0.8
Seeking ratio, punishment vs. effort	0.5	1.0	3.4	1.8	-1.8	1.1	0.3	-0.3	-0.6	0.3	0.8	-0.2
Retroperitoneal fat weight	2.1	9.2	21.9	-1.9	0.1	-0.2	2.8	-3.4	-3.1	-4.7	3.6	4.0
Reaction time number correct	0.7	2.4	6.9	2.6	-2.0	0.6	1.9	-1.8	-1.4	-0.5	1.0	0.6
Reaction time mean minus median	0.0	0.3	1.0	-0.7	1.0	-0.3	-0.4	0.5	0.6	0.1	-0.3	-0.1
Reaction time mean minus median AUC	0.1	0.6	1.8	-0.7	1.2	-1.4	-0.5	0.5	0.7	0.2	-0.7	-0.3
Reaction time num false alarms	0.1	0.2	0.5	-0.7	-0.5	0.2	0.2	0.5	-0.5	-0.1	0.1	0.4
Reaction time num false alarms AUC	0.3	0.6	1.9	0.0	-1.4	0.8	0.9	-0.1	-1.1	-0.3	0.4	0.7
Reaction time trials correct on left	0.7	2.4	6.9	2.6	-2.0	0.6	1.9	-1.8	-1.4	-0.5	1.0	0.6
Reaction time trials on left	0.7	2.4	6.7	2.6	-2.0	0.5	1.9	-1.8	-1.4	-0.5	1.0	0.6
Reaction time mean	1.8	4.0	8.3	-2.6	2.9	-1.5	-2.1	1.9	2.0	1.3	-1.9	-0.7
Reaction time mean AUC	1.4	3.3	8.2	-2.7	2.9	-1.6	-1.8	1.5	1.7	0.8	-1.6	-0.3
Median of all reaction times	2.6	4.1	8.9	-2.8	3.0	-1.4	-2.2	1.9	2.0	1.2	-2.0	-0.7
Reaction time omissions	0.1	0.1	0.4	0.0	-0.6	0.6	0.3	0.2	-0.4	-0.0	-0.0	0.5
Reaction time false alarm rate	0.2	0.3	1.6	-1.3	-0.3	0.5	-0.1	0.8	-0.4	-0.1	-0.1	0.4
Reaction time premature initiation rate	0.3	0.5	2.6	0.1	-0.0	1.6	0.1	0.1	-0.3	-0.7	0.7	0.8
Reaction time premature initiations	0.5	1.4	3.3	1.3	-1.0	1.8	1.0	-0.9	-1.0	-1.1	1.2	1.1
Std. dev. reaction times	0.5	1.7	3.5	-1.9	1.9	-1.3	-1.2	1.4	1.2	0.8	-1.2	-0.2
Reaction time trials completed	0.7	2.4	6.7	2.6	-2.0	0.5	1.9	-1.8	-1.4	-0.5	1.0	0.6
Reaction time trials AUC	0.6	2.2	6.0	2.5	-1.9	0.4	1.8	-1.7	-1.4	-0.6	1.0	0.7
Run reversals in cocaine runway, females	1.5	1.7	6.4	-2.5	1.2	-1.9	-1.2	1.1	0.6	0.0	-0.7	0.4
Run reversals in cocaine runway, males	0.4	0.5	1.0	-0.5	1.0	-0.6	-0.8	0.6	0.8	0.3	-0.6	-0.7
Latency to leave start box in cocaine runway	0.6	0.9	3.8	-2.0	0.8	0.1	-1.3	0.9	0.7	-0.2	0.5	-0.1
Latency to leave start box in cocaine runway, F	0.5	0.7	3.1	-1.8	0.3	0.5	-0.7	0.2	-0.0	-0.8	1.1	0.4
Latency to leave start box in cocaine runway, M	2.1	2.0	3.1	-1.3	1.4	-1.3	-1.8	1.7	1.6	1.1	-1.1	-1.2
Std. dev. time between licks in bursts	0.3	0.7	2.1	1.2	-1.5	-0.8	0.5	-0.6	-0.7	-0.1	0.6	-0.1
Total sessions with >9 infusions	1.4	1.7	3.1	-0.5	0.8	-1.2	-1.3	1.4	1.4	1.7	-1.8	-1.3
Short access day 1 total inactive lever presses	1.9	3.8	6.6	-2.6	2.4	-2.2	-2.1	1.9	1.9	1.1	-1.8	-0.9
Short access day 10 total inactive lever presses	0.0	0.2	0.4	-0.6	0.6	0.1	-0.6	0.7	0.5	0.1	0.1	-0.1
Short access day 1 total infusions	0.2	0.4	1.0	-0.6	0.7	-1.0	-0.7	0.5	0.7	0.4	-0.6	-0.5
Short access day 10 total infusions	0.1	0.2	1.3	-0.6	0.5	-1.1	-0.2	0.1	0.2	0.2	-0.5	0.1
Short access total infusions	0.0	0.0	0.1	-0.1	0.3	-0.3	-0.1	-0.0	0.1	-0.0	-0.2	0.0
Short access day 1 locomotion	1.9	3.2	6.2	-2.2	2.5	-0.9	-1.9	1.7	2.0	1.2	-1.8	-1.1
Short access day 10 total locomotion	0.1	0.5	1.5	0.1	-0.5	0.3	-0.7	1.0	0.4	1.2	-0.8	-0.6
Short access total locomotion	0.4	0.6	1.8	1.3	-1.3	1.2	0.2	0.1	-0.3	0.7	-0.1	-0.3
One hour access (0.3 mA shock)	4.9	5.8	8.6	-2.9	2.8	-1.8	-2.9	2.9	2.6	1.9	-2.1	-1.4
Compulsive drug intake	2.3	3.3	4.8	-1.9	1.5	-2.2	-1.9	2.0	1.8	1.8	-1.8	-1.4
One hour access (shock baseline)	0.8	2.1	6.4	-2.5	2.5	-0.7	-1.4	1.3	1.3	0.2	-0.8	0.1
Social response proportion	3.0	3.8	8.4	-2.9	2.9	-2.0	-2.4	1.7	1.9	0.4	-0.9	-0.5
Social responses	4.4	5.8	9.7	-2.0	2.8	-2.4	-3.1	2.7	2.8	1.8	-1.9	-1.9
Social time	1.0	1.5	4.1	2.0	-1.3	-0.0	-0.9	1.1	0.7	1.6	-0.6	-1.6
Soleus weight	0.2	0.5	1.6	0.6	-1.2	1.2	0.3	0.0	-0.7	-0.5	0.6	-0.0
Bone: stiffness	1.1	1.9	3.5	-0.1	0.5	0.7	-1.7	1.9	1.6	1.6	-1.2	-1.9
Tibialis anterior weight	1.3	4.5	7.0	1.7	-2.3	1.3	2.4	-2.4	-2.7	-2.2	2.2	1.6
Time to tail flick, vehicle, before self-admin	0.5	0.6	3.1	0.5	-1.1	1.8	0.4	-0.2	-0.5	-0.1	0.5	0.2
Time to tail flick, vehicle, after self-admin	1.3	2.7	6.1	-2.3	2.5	0.7	-2.1	1.7	1.8	0.4	-1.1	-0.9
Time to tail flick, test, before self-admin	4.1	4.7	13.5	3.5	-3.7	2.4	1.8	-1.4	-1.8	-0.2	1.4	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.8	-0.9	-0.0	0.1	0.3	-0.4	-0.3	-0.3	-0.1	0.5
Delta time to tail flick, vehicle, before/after SA	1.6	1.7	4.9	-1.9	2.2	0.1	-1.5	1.1	1.4	0.2	-0.8	-0.7
Delta time to tail flick, test, before/after SA	2.5	3.0	9.9	-3.1	2.7	-1.9	-1.3	1.0	1.4	0.3	-1.3	-0.1
Tibia length	1.6	4.4	9.4	0.9	0.1	-0.9	-2.1	2.5	2.2	3.1	-2.3	-2.7
Ambulatory time before self-admin	0.8	2.3	9.6	3.1	-2.7	0.3	0.4	0.0	-0.5	1.4	-0.2	-1.0
Ambulatory time after self-admin	3.6	5.8	16.3	4.0	-4.0	2.5	2.2	-1.5	-2.1	-0.1	1.3	0.5
Bone: tissue strength	2.6	2.8	7.3	2.0	-2.6	2.7	1.2	-0.7	-1.5	-0.7	1.6	0.5
Total heroin consumption	0.2	0.3	0.5	0.4	-0.7	-0.4	0.5	-0.5	-0.6	-0.4	0.5	0.5
Bone: trabecular number	0.8	1.6	4.8	2.1	-1.5	2.2	1.1	-0.8	-0.8	-0.2	0.2	-0.4
Bone: trabecular spacing	0.1	0.2	1.4	0.1	-0.2	-1.2	0.1	-0.3	-0.1	-0.1	0.2	0.2
Bone: trabecular thickness	0.1	0.1	0.5	-0.7	0.3	0.2	-0.3	0.6	0.2	-0.0	-0.3	-0.2
Bone: trabecular tissue density	1.1	1.9	7.7	-2.8	2.2	-1.1	-0.4	-0.2	0.2	-1.2	0.5	1.2
Water consumed over 24 hours	0.4	0.8	2.4	1.5	-0.8	1.5	-0.3	0.3	0.2	0.5	0.1	-1.0
Number of responses in last shaping day	2.5	3.2	9.0	-3.0	2.6	-2.1	-1.9	1.4	1.5	0.4	-1.1	-0.2