Hub : Genes

Zpbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr10_83563545_83567063 0.02 0.02 7.9e-04 0.02 0.03 0.02 0.02 8.3e-04 6.5e-04 1.3e-03 1.3e-03
2 BLA intron excision ratio chr10_83560463_83563463 0.05 0.04 8.1e-03 0.01 0.03 0.01 0 1.5e-01 1.3e-02 1.1e-01 1.9e-01
3 NAcc gene expression Zpbp2 0.05 0.04 2.3e-05 0.02 0.03 0.03 0.03 2.6e-03 8.3e-05 3.3e-04 2.6e-04
4 Liver intron excision ratio chr10_83563545_83567063 0.04 0.03 1.2e-06 0.03 0.04 0.05 0.03 1.3e-04 5.2e-05 5.2e-06 7.3e-04
5 Brain intron excision ratio chr10_83563545_83567063 0.07 0.06 7.3e-03 0.02 0.01 -0 0.02 2.5e-03 4.1e-02 8.3e-01 1.0e-02
6 PL gene expression Zpbp2 0.06 0.05 3.7e-06 0.05 0.05 0.04 0.05 1.7e-06 3.8e-06 1.5e-05 1.6e-06
7 BLA gene expression Zpbp2 0.08 0.06 2.0e-03 0.02 0.03 0.02 0.01 2.9e-02 1.5e-02 2.9e-02 6.2e-02
8 Liver intron excision ratio chr10_83566539_83567063 0.03 0.02 4.3e-03 0.03 0.01 0.02 0 7.2e-04 4.1e-02 5.9e-03 3.0e-01
9 PL intron excision ratio chr10_83563545_83567063 0.03 0.02 8.8e-04 0.02 0.02 0.01 0.01 2.9e-03 2.9e-03 8.2e-03 9.2e-03
10 Brain gene expression Zpbp2 0.1 0.06 1.7e-08 0.07 0.08 0.07 0.08 6.9e-07 1.2e-07 1.9e-07 1.4e-07
11 Liver gene expression Zpbp2 0.66 0.19 4.6e-10 0.06 0.07 0.06 0.07 1.4e-07 6.9e-08 1.6e-07 4.6e-08
12 Adipose gene expression Zpbp2 0.14 0.1 1.8e-09 0.06 0.07 0.07 0.07 5.9e-07 1.3e-08 7.4e-08 4.2e-08
13 Adipose intron excision ratio chr10_83560463_83563463 0.52 0.16 8.9e-04 0.04 0.03 0.04 0.04 7.7e-05 1.1e-04 1.3e-05 1.0e-05
14 Liver intron excision ratio chr10_83560463_83563463 0.48 0.18 4.1e-03 0.03 0.01 0.02 0.03 1.2e-04 5.6e-02 8.8e-04 4.0e-04
15 Liver mRNA stability Zpbp2 0.09 0.06 2.8e-04 0.03 0.03 0.01 0.03 5.2e-04 6.2e-04 3.4e-02 5.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.93.25.12.01.91.9-2.0-1.92.12.11.5-2.32.01.51.91.4-0.5-0.7
Area under the delay curve0.30.30.50.70.70.5-0.7-0.60.60.60.7-0.70.30.20.60.40.0-0.0
BMI with tail2.06.510.9-3.0-3.2-3.12.82.3-2.4-2.3-3.32.1-2.4-2.4-1.33.2-1.7-1.5
BMI without tail0.10.32.4-0.4-0.5-0.50.10.2-0.1-0.3-0.4-0.3-0.4-0.9-0.21.6-0.10.1
Body weight4.518.930.3-5.4-5.5-5.04.94.7-4.4-4.7-5.23.9-4.0-4.2-3.44.1-1.9-1.7
Weight adjusted by age0.30.40.9-0.6-0.8-0.81.00.5-0.7-0.3-0.70.9-0.2-0.10.20.1-0.6-0.6
Bone surface0.30.42.5-0.1-0.2-0.1-0.0-0.30.30.3-0.6-0.50.40.10.51.6-1.1-1.2
Bone volume0.61.04.20.30.00.2-0.3-0.60.70.7-0.5-0.90.80.61.12.0-1.6-1.8
Breakpoint value in progressive ratio session0.20.20.7-0.4-0.10.30.30.1-0.2-0.60.50.60.50.5-0.8-0.3-0.1-0.1
Number of licking bursts0.50.63.10.40.20.1-0.1-0.30.40.8-0.1-0.40.50.51.21.8-1.3-1.2
Context. condit. distance diff. score1.41.73.4-1.0-0.7-1.11.21.4-1.5-1.3-0.51.4-1.8-1.5-1.5-1.11.51.3
Locomotion velocity, session 10.40.41.0-0.8-1.0-0.80.60.5-0.4-0.6-1.00.2-0.4-0.6-0.31.0-0.5-0.6
Locomotion distance, session 12.22.85.7-2.1-2.2-1.91.81.4-1.2-1.8-2.20.9-1.1-1.6-1.22.4-1.3-1.2
Locomotion velocity, session 20.20.20.6-0.5-0.5-0.30.20.3-0.2-0.6-0.20.1-0.2-0.7-0.80.50.50.4
Locomotion distance, session 20.50.74.2-0.8-0.9-0.50.50.10.1-0.5-0.9-0.30.3-0.3-0.22.0-1.3-1.4
Locomotion velocity, session 30.20.20.80.10.20.4-0.5-0.10.4-0.30.6-0.40.2-0.4-0.80.20.90.8
Locomotion distance, session 30.20.20.5-0.6-0.6-0.50.30.3-0.2-0.6-0.40.1-0.3-0.7-0.60.50.20.2
Stereotopy head waving bouts, day 32.12.44.22.02.11.9-1.9-1.61.71.81.8-1.71.41.41.3-0.30.40.5
Stereotopy head waving duration, day 30.10.10.30.50.50.3-0.4-0.20.30.50.3-0.30.10.30.50.4-0.10.1
Locomotion velocity, session 70.91.02.0-1.2-1.4-1.31.31.0-1.0-1.0-1.41.1-0.8-0.8-0.40.3-0.5-0.5
Locomotion distance, session 70.40.51.0-0.7-0.8-0.80.90.5-0.7-0.6-0.90.9-0.7-0.3-0.2-1.00.0-0.1
Stereotopy head waving bouts, day 70.50.61.50.90.80.6-0.7-0.60.81.00.5-0.90.60.31.01.2-0.4-0.2
Stereotopy head waving duration, day 70.30.31.20.60.50.5-0.6-0.40.70.60.4-0.80.50.10.51.1-0.2-0.0
Locomotion velocity, session 86.17.310.1-3.2-3.1-3.13.13.1-3.0-3.1-2.72.9-3.1-3.0-2.70.50.50.5
Locomotion distance, session 81.11.62.4-1.5-1.5-1.41.51.3-1.3-1.4-1.51.2-1.2-1.2-1.10.7-0.2-0.3
Degree of sensitization distance1.01.02.3-1.0-1.0-1.11.31.1-1.4-0.9-1.11.5-1.2-0.6-0.6-1.10.20.1
Degree of sensitization stereotypy0.80.81.91.10.90.8-0.8-0.80.91.30.6-1.00.90.71.41.0-0.6-0.5
Conditioned locomotion0.30.30.90.50.50.5-0.6-0.40.40.20.7-0.30.30.0-0.0-1.00.90.8
Cocaine response after cond. corrected1.11.34.61.00.60.5-0.5-1.00.91.50.0-0.81.01.32.20.3-1.6-1.6
Cocaine response after cond. not corrected1.41.66.21.20.80.6-0.5-1.21.01.80.1-0.81.11.52.50.0-1.7-1.7
Cocaine response before conditioning0.20.20.90.60.60.3-0.2-0.30.20.50.4-0.10.10.40.5-1.00.50.3
Saline control response0.30.41.0-0.3-0.5-0.70.90.4-0.60.1-0.90.8-0.50.00.80.1-1.0-0.8
Bone: connectivity density2.64.16.62.42.32.3-2.4-2.22.52.32.0-2.62.31.61.90.90.0-0.2
Bone: cortical apparent density5.57.211.33.23.43.2-3.1-3.12.82.73.3-2.72.42.71.7-2.11.01.1
Bone: cortical area0.00.10.30.40.30.2-0.1-0.20.20.40.2-0.20.10.30.5-0.1-0.30.0
Bone: cortical porosity0.30.41.40.30.10.0-0.2-0.40.40.7-0.2-0.20.40.71.20.3-1.0-1.2
Bone: cortical porosity0.50.52.00.2-0.1-0.20.1-0.30.20.7-0.5-0.00.30.81.40.2-1.3-1.4
Bone: cortical thickness0.91.42.71.61.61.3-1.2-1.21.21.41.6-1.20.80.91.1-0.60.60.9
Bone: cortical thickness4.35.08.22.82.92.7-2.5-2.42.42.42.7-2.22.22.31.6-1.40.70.8
Bone: cortical tissue density5.57.211.33.23.43.2-3.1-3.12.82.73.3-2.82.52.71.7-2.11.01.1
Condit. Reinf. active minus inactive responses1.01.12.21.11.31.3-1.2-1.01.20.71.5-1.30.90.50.1-0.51.11.2
Condit. Reinf. active-inactive response ratio1.41.53.21.31.51.4-1.3-0.91.00.71.8-1.00.80.4-0.1-1.31.61.8
Condit. Reinf. active responses0.91.11.91.21.31.3-1.2-1.01.20.91.4-1.30.90.70.4-0.50.81.0
Condit. Reinf. inactive responses0.20.20.90.40.30.2-0.1-0.40.40.70.0-0.40.40.61.00.2-0.6-0.5
Incentive salience index mean1.82.13.71.71.71.8-1.7-1.71.81.41.7-1.91.51.20.8-0.40.50.6
Condit. Reinf. lever presses0.91.22.51.21.11.2-1.1-1.51.51.30.8-1.61.21.11.10.1-0.3-0.2
Condit. Reinf. active minus inactive responses0.81.02.01.11.11.2-1.0-1.11.11.10.9-0.91.41.40.9-0.0-0.6-0.7
Condit. Reinf. active-inactive response ratio0.90.91.70.80.81.0-0.9-1.01.00.90.5-1.01.31.30.80.7-0.9-1.1
Condit. Reinf. active responses1.52.03.71.41.31.6-1.4-1.51.51.51.1-1.31.91.91.40.5-1.2-1.2
Condit. Reinf. inactive responses1.62.03.11.51.41.5-1.3-1.61.61.71.1-1.41.71.81.70.1-1.1-0.8
Condit. Reinf. lever presses0.10.10.40.30.40.5-0.4-0.20.20.20.7-0.10.40.30.0-0.10.10.0
Condit. Reinf. lever reinforcers received1.42.03.61.51.51.7-1.4-1.61.61.51.4-1.41.91.81.20.3-1.0-0.8
Conditioned reinforcement - actives0.60.61.80.91.00.8-0.5-0.50.40.91.00.10.71.10.8-1.30.1-0.2
Conditioned reinforcement - inactives1.71.93.21.51.71.8-1.6-1.51.21.31.8-0.81.41.80.6-1.40.40.3
Conditioned locomotion0.50.61.40.90.80.6-0.4-0.90.51.00.9-0.30.70.81.2-0.2-0.5-0.7
Patch foraging indifference point 0 sec1.62.64.41.92.12.0-2.0-1.71.71.52.1-1.71.51.10.8-1.00.91.1
Patch foraging indifference point AUC0.00.00.2-0.2-0.2-0.30.20.1-0.0-0.1-0.30.1-0.1-0.20.1-0.50.20.0
Delay disc. indifference point, 0s delay0.90.91.71.21.21.1-1.0-1.01.01.21.1-0.71.01.31.00.0-0.3-0.3
Delay disc. indifference point, 16s delay0.70.72.20.81.00.7-0.9-0.80.40.50.9-0.40.0-0.00.0-1.21.51.5
Delay disc. indifference point, 2s delay1.31.43.11.21.00.8-0.7-1.21.11.50.7-1.11.11.31.80.9-1.5-1.5
Delay disc. indifference point, 24s delay0.10.10.50.10.1-0.2-0.20.1-0.2-0.10.10.1-0.4-0.7-0.10.10.60.6
Delay disc. indifference point, 4s delay0.70.71.20.90.90.9-0.8-0.90.80.91.1-0.60.91.10.90.1-0.7-0.7
Delay disc. indifference point, 8s delay0.10.10.40.40.40.2-0.6-0.20.40.40.4-0.50.1-0.10.50.40.20.2
Indifference point function ln k0.10.20.90.10.30.1-0.20.2-0.1-0.10.6-0.1-0.4-0.5-0.50.00.90.9
Indifference point function log k0.10.20.90.10.30.1-0.20.2-0.1-0.10.6-0.1-0.4-0.5-0.50.00.90.9
Patch foraging total patch changes 0 sec1.21.93.11.61.71.7-1.8-1.41.51.21.8-1.51.20.80.6-0.91.01.1
Patch foraging total patch changes 12 sec4.45.78.32.72.62.7-2.7-2.82.92.72.2-2.62.92.52.30.0-0.7-0.7
Patch foraging total patch changes 18 sec0.40.50.90.90.90.8-0.9-0.80.80.80.9-0.70.80.40.6-0.40.40.4
Patch foraging total patch changes 24 sec1.31.52.61.61.51.3-1.3-1.41.31.51.2-1.21.10.91.4-0.90.80.5
Patch foraging total patch changes 6 sec1.82.74.81.91.91.9-2.1-2.02.11.71.7-2.21.81.41.2-0.30.10.3
Patch foraging time to switch 0 sec0.10.10.20.30.20.3-0.3-0.40.40.40.1-0.30.50.30.30.20.1-0.0
Patch foraging water rate 0 sec0.10.10.20.20.30.4-0.5-0.40.30.00.5-0.50.30.1-0.20.1-0.10.0
Patch foraging water rate 12 sec0.20.31.0-0.3-0.1-0.10.40.7-0.7-0.50.21.0-0.2-0.0-0.6-0.80.50.4
Patch foraging water rate 18 sec0.60.81.50.70.70.7-0.7-0.60.90.90.6-1.00.90.90.91.1-1.2-1.2
Patch foraging water rate 24 sec0.60.91.90.90.91.1-1.1-1.11.10.80.9-1.41.00.90.50.8-0.6-0.8
Patch foraging water rate 6 sec1.31.92.91.51.51.7-1.6-1.51.71.41.6-1.61.71.51.0-0.0-0.5-0.3
Seeking ratio, delayed vs. immediate footshock0.91.14.10.60.90.9-0.4-0.70.1-0.01.20.40.20.6-0.7-2.01.62.0
Distance traveled before self-admin0.40.42.0-0.3-0.4-0.10.3-0.0-0.7-0.2-0.21.30.30.80.0-0.6-1.1-1.4
Distance traveled after self-admin1.21.32.1-1.5-1.4-1.21.11.4-1.3-1.3-1.31.3-0.9-0.8-1.10.5-0.6-1.0
Extensor digitorum longus weight7.529.540.5-6.3-6.1-6.26.16.2-6.4-6.2-5.66.2-6.2-5.9-5.1-0.21.41.2
Bone: elastic displacement0.00.00.30.10.10.00.00.10.00.00.1-0.1-0.1-0.1-0.00.50.20.2
Bone: elastic work0.20.21.10.10.10.2-0.0-0.30.30.20.1-0.30.40.40.31.0-0.9-0.5
Bone: endosteal estimation2.04.49.4-2.5-2.7-2.52.32.0-2.2-1.9-3.12.1-1.6-1.6-1.01.4-1.6-1.8
Bone: endosteal perimeter1.12.24.3-2.0-2.0-1.71.61.5-1.7-1.7-2.11.7-1.2-1.1-1.2-0.0-0.6-0.8
Epididymis fat weight0.10.30.7-0.7-0.7-0.40.50.3-0.3-0.6-0.40.40.10.1-0.50.6-0.8-0.8
Delta time in closed arm before/after self-admin3.02.94.6-2.1-2.1-2.02.01.9-1.6-1.9-2.21.1-1.9-2.0-1.51.20.10.1
Delta time in open arm before/after self-admin0.00.00.20.10.10.00.0-0.0-0.10.10.10.1-0.10.40.2-0.3-0.4-0.1
Diff in mean of infusions in LGA sessions0.10.10.3-0.4-0.2-0.00.50.6-0.3-0.50.20.50.20.1-0.60.10.10.0
Delay discount exponential model param0.10.20.3-0.4-0.5-0.30.50.4-0.4-0.4-0.50.6-0.1-0.0-0.4-0.50.00.0
Extinction: sum of active levers before priming1.41.42.5-1.4-1.5-1.61.31.4-1.2-1.1-1.51.0-1.2-1.4-0.51.0-0.4-0.3
Active lever presses in extinction session 62.42.39.30.70.40.8-0.8-1.41.01.20.4-0.61.91.81.61.4-2.7-3.1
Bone: final force0.81.34.10.90.50.5-0.5-0.90.81.4-0.0-0.81.01.21.91.1-2.0-1.7
Bone: final moment0.71.24.30.70.40.3-0.3-0.70.61.2-0.3-0.60.81.01.81.3-2.1-1.7
Food consumed during 24 hour testing period0.70.81.2-1.1-1.0-1.01.01.1-1.1-0.9-1.01.1-0.9-0.7-0.70.7-0.4-0.4
Glucose0.20.31.20.40.30.10.1-0.60.30.7-0.2-0.20.20.81.1-0.7-0.8-0.7
Heart weight2.63.75.6-2.4-2.3-2.22.31.8-2.0-2.2-2.31.7-2.2-2.0-1.91.4-0.5-0.6
Delay discount hyperbolic model param0.20.30.5-0.6-0.6-0.40.60.6-0.6-0.6-0.70.7-0.3-0.2-0.6-0.60.20.2
Intermittent access intake day 1-15 change0.40.40.90.60.80.9-0.8-0.50.90.41.0-1.00.80.60.00.20.30.3
Intermittent access intake escalation0.40.40.90.60.70.9-0.8-0.60.80.41.0-0.90.80.70.00.30.10.1
Intermittent access intake escalation 20.10.10.5-0.1-0.00.2-0.2-0.00.3-0.10.2-0.50.30.1-0.20.7-0.2-0.2
Intermitt. access day 1 inactive lever presses2.22.46.31.31.41.7-2.0-1.92.11.21.6-2.51.81.30.61.1-0.5-0.5
Intermitt. access day 15 inactive lever presses4.24.69.22.42.42.5-2.6-2.52.72.12.5-3.02.21.91.4-0.20.00.3
Intermitt. access escalation Index2.01.83.5-1.3-1.4-1.61.41.9-1.6-1.1-1.71.5-1.6-1.5-0.61.00.00.1
Intermittent access day 1 total infusions0.20.30.90.40.40.5-0.2-0.30.00.40.40.50.61.00.4-0.7-0.6-0.8
Intermittent access day 15 total infusions0.50.51.10.80.91.1-0.8-0.70.70.61.0-0.40.91.00.2-0.60.1-0.0
Intermittent access terminal intake (last 3 days)0.60.61.30.80.91.1-0.9-0.80.80.71.0-0.51.01.20.4-0.4-0.2-0.3
Intermittent access total infusions0.20.20.80.30.50.6-0.3-0.30.10.20.60.30.60.90.0-0.9-0.2-0.3
Intermittent access day 1 locomotion0.20.20.80.60.60.5-0.4-0.60.20.50.50.20.40.60.5-0.9-0.0-0.2
Intermittent access day 15 total locomotion0.30.40.60.70.70.6-0.4-0.60.50.80.5-0.30.60.70.70.3-0.6-0.7
Intermittent access total locomotion0.60.71.31.01.11.1-0.8-0.80.70.91.2-0.30.90.90.6-0.70.30.1
Intermittent access standard deviation1.71.83.81.31.61.9-1.7-1.31.50.92.0-1.31.71.30.0-0.71.00.8
Left kidney weight1.02.85.9-2.0-1.8-1.51.31.7-1.6-2.2-1.21.4-1.7-2.3-2.40.61.11.0
Right kidney weight0.20.62.7-0.9-0.9-0.70.60.6-0.5-0.8-1.00.4-0.3-0.8-0.61.6-0.4-0.4
Cocaine induced anxiety2.32.68.3-1.8-2.0-1.81.51.6-1.3-1.3-1.90.9-1.1-1.3-0.72.9-1.7-1.4
Post-drug Anxiety0.30.31.1-0.5-0.6-0.60.60.5-0.5-0.2-0.70.4-0.3-0.20.21.0-1.0-0.5
Baseline Anxiety1.71.84.71.71.71.3-1.1-1.31.11.41.5-0.80.71.11.1-2.21.11.6
Tail length0.20.72.4-0.9-0.7-0.50.40.9-0.7-1.3-0.10.7-0.6-1.0-1.6-0.40.91.0
Length with tail2.28.213.9-3.6-3.4-3.03.03.3-3.1-3.7-2.72.9-2.7-3.0-3.50.90.30.4
Length without tail3.27.011.3-3.4-3.4-3.03.22.9-3.0-3.0-3.12.9-2.3-2.1-2.31.3-1.1-1.2
Times rat made contact with spout1.11.22.61.00.90.9-1.0-1.11.21.30.6-1.41.00.91.31.6-0.9-1.0
Lifetime Intake0.20.30.90.40.50.7-0.5-0.40.20.20.70.10.70.9-0.0-0.7-0.2-0.3
Liver weight, left0.00.00.3-0.00.10.2-0.0-0.10.1-0.10.30.20.30.3-0.2-0.60.00.1
Liver weight, right0.30.51.10.70.70.9-0.9-1.00.80.60.7-0.71.10.90.2-0.50.1-0.1
Locomotor activity0.61.02.00.80.60.7-0.5-0.70.91.10.4-0.91.11.01.41.2-1.4-1.3
Locomotor testing distance1.72.84.22.01.91.8-1.8-1.81.92.11.8-1.81.91.62.00.2-0.6-0.3
Locomotor testing rearing5.28.112.63.43.53.4-3.6-3.23.23.03.5-3.22.92.42.0-1.10.91.0
Locomotion in novel chamber4.55.69.72.92.72.6-2.2-2.72.32.92.4-1.52.63.12.7-1.2-0.9-1.0
Locomotion in novel chamber post-restriction1.72.06.10.90.70.9-0.8-1.11.01.30.5-1.01.51.61.61.8-2.5-2.4
Fecal boli incidents, locomotor time 10.20.30.5-0.5-0.6-0.60.60.4-0.6-0.4-0.70.7-0.5-0.4-0.10.3-0.5-0.5
Change in fecal boli incidents, locomotor task0.10.10.5-0.00.0-0.10.40.3-0.20.0-0.10.3-0.30.10.2-0.7-0.1-0.0
Time >=10cm from walls, locomotor time 10.60.62.60.70.70.4-0.3-0.50.20.50.80.0-0.0-0.00.3-1.61.31.3
Bouts of movement, locomotor time 10.50.51.2-0.9-0.9-0.80.41.0-0.7-0.8-0.60.5-0.5-1.1-0.60.60.30.3
Total resting periods, locomotor time 10.91.01.9-1.2-1.3-1.31.01.4-1.0-1.1-1.20.8-0.8-1.3-0.70.9-0.1-0.1
Rest time, locomotor task time 10.20.21.6-0.0-0.1-0.0-0.40.20.40.1-0.2-0.80.2-0.20.21.3-0.5-0.6
Distance moved, locomotor task time 10.20.21.40.30.40.3-0.0-0.70.00.40.20.40.20.70.4-1.20.20.2
Vertical activity count, locomotor time 10.20.21.2-0.3-0.3-0.40.90.0-0.6-0.3-0.21.1-0.30.20.0-0.6-0.2-0.2
Time >=10cm from walls, locomotor time 21.11.24.91.31.20.9-0.3-0.90.51.31.10.41.01.41.5-2.20.20.2
Bouts of movement, locomotor time 20.50.62.40.50.60.5-0.9-0.40.50.20.9-0.50.3-0.3-0.3-0.91.61.5
Total resting periods, locomotor time 20.60.63.10.30.40.4-0.8-0.20.3-0.10.8-0.40.1-0.5-0.6-0.81.81.7
Rest time, locomotor task time 20.70.81.4-1.1-1.1-1.00.91.2-0.9-1.1-1.00.8-0.8-1.0-0.90.60.10.1
Distance moved, locomotor task time 20.10.10.4-0.2-0.3-0.30.4-0.4-0.10.1-0.60.1-0.20.20.4-0.3-0.4-0.4
Vertical activity count, locomotor time 20.20.20.6-0.5-0.5-0.60.80.2-0.5-0.4-0.50.6-0.6-0.3-0.10.1-0.1-0.1
Light reinforcement 12.54.69.12.32.32.5-2.6-2.52.82.12.2-3.02.51.81.50.8-0.50.0
Light reinforcement 21.11.43.10.80.60.7-0.8-1.41.41.1-0.0-1.81.10.91.21.7-1.8-1.4
Bone: marrow area1.94.18.9-2.4-2.7-2.42.22.0-2.1-1.9-3.02.1-1.5-1.5-1.01.4-1.5-1.8
Bone: maximum diameter0.00.10.30.10.10.1-0.1-0.20.20.3-0.1-0.10.30.40.4-0.1-0.6-0.5
Bone: maximum force0.30.52.4-0.2-0.4-0.40.40.1-0.20.2-0.80.1-0.00.10.71.2-1.5-1.2
Bone: maximum moment0.30.52.3-0.4-0.6-0.60.60.3-0.30.1-1.00.2-0.2-0.10.61.4-1.5-1.1
Mean time between licks in bursts1.01.42.2-1.5-1.5-1.41.21.3-1.4-1.3-1.41.4-1.1-1.0-1.00.5-0.5-0.3
Mean num. licks in bursts0.20.20.40.40.50.6-0.6-0.50.50.20.5-0.70.30.3-0.2-0.60.50.4
Cd content in liver0.20.20.70.30.30.4-0.5-0.40.40.30.4-0.60.30.00.20.9-0.4-0.2
Co content in liver0.50.61.8-0.9-0.7-0.60.60.7-0.6-1.1-0.50.5-0.8-0.8-1.4-0.40.90.7
Cu content in liver0.20.31.2-0.20.10.3-0.3-0.10.1-0.60.5-0.10.1-0.2-1.1-0.70.90.8
Fe content in liver0.91.01.8-1.3-1.3-1.21.21.0-1.0-1.1-1.31.0-0.8-0.9-0.80.8-0.6-0.4
K content in liver1.11.11.81.11.21.2-1.2-1.11.11.01.3-0.91.31.20.7-0.80.1-0.1
Mg content in liver1.61.75.01.21.51.4-1.4-0.90.90.71.9-0.70.80.6-0.0-2.21.71.5
Mn content in liver2.02.34.61.71.92.0-2.0-1.51.71.22.2-1.61.61.10.4-0.81.10.8
Na content in liver0.60.62.30.40.10.2-0.2-0.40.40.7-0.2-0.20.91.01.20.6-1.4-1.5
Rb content in liver1.21.52.31.51.51.5-1.5-1.51.41.31.4-1.31.31.30.9-0.70.20.2
Se content in liver4.65.79.02.62.83.0-3.0-2.72.72.22.9-2.52.72.51.3-1.60.60.4
Sr content in liver0.40.41.40.20.50.6-0.4-0.20.2-0.20.80.00.20.2-0.7-1.21.01.0
Zn content in liver2.73.04.61.91.92.1-2.1-2.02.01.71.8-1.92.02.11.1-0.5-0.2-0.2
Bone: minimum diameter0.50.91.8-1.1-1.2-1.11.10.8-0.9-0.8-1.30.8-0.7-0.7-0.40.8-1.0-0.6
Time in familiar zone, hab. session 11.31.25.00.3-0.00.2-0.2-0.90.60.9-0.6-0.70.81.31.40.9-2.2-2.2
Time in novel zone, hab. session 11.11.13.21.01.21.0-1.1-0.60.80.51.5-1.00.2-0.2-0.2-0.61.71.8
Total zone transitions, hab. session 11.31.82.8-1.7-1.6-1.51.51.5-1.4-1.7-1.41.1-1.5-1.5-1.60.30.30.4
Total locomotion distance, hab. session 10.00.00.2-0.10.10.10.1-0.0-0.0-0.20.2-0.2-0.2-0.0-0.50.00.10.1
Locomotion velocity, hab. session 10.20.41.0-0.7-0.5-0.40.60.7-0.7-0.9-0.30.6-0.6-0.5-1.0-0.20.30.2
Time in familiar zone, hab. session 20.70.71.40.60.50.7-0.6-0.90.80.80.3-0.80.91.10.90.7-1.1-1.2
Time in novel zone, hab. session 20.30.31.20.50.60.5-0.6-0.20.40.20.8-0.50.3-0.1-0.2-0.40.91.1
Total zone transitions, hab. session 20.70.91.7-1.2-1.2-1.21.30.9-0.9-1.0-1.30.7-1.0-1.0-0.60.7-0.3-0.4
Total locomotion distance, hab. session 20.40.52.0-0.6-0.7-0.60.80.3-0.3-0.4-0.90.1-0.4-0.2-0.01.4-1.1-1.1
Locomotion velocity, hab. session 20.50.61.2-0.9-0.9-0.91.00.6-0.6-0.6-1.10.5-0.6-0.4-0.31.1-0.9-1.0
Novel to familiar place preference ratio1.41.42.8-1.0-0.8-0.90.81.2-1.2-1.3-0.41.3-1.1-1.3-1.4-1.51.51.7
Novelty place preference1.51.54.1-0.8-0.6-0.80.61.1-1.2-1.1-0.21.3-1.2-1.3-1.3-1.81.92.0
Time in novel zone, NPP test0.90.93.4-0.3-0.2-0.40.20.7-0.7-0.70.10.9-0.8-0.9-0.9-1.71.71.8
Total zone transitions, NPP test0.71.02.8-1.0-1.2-1.11.20.6-0.7-0.6-1.70.6-0.6-0.30.11.3-1.3-1.5
Total locomotion distance, NPP test0.40.62.6-0.2-0.4-0.30.4-0.10.10.2-0.9-0.30.10.30.61.6-1.5-1.6
Locomotion velocity, NPP test0.50.72.1-0.8-0.9-0.80.90.5-0.5-0.5-1.30.3-0.5-0.3-0.11.5-1.2-1.3
Intraocular pressure2.12.94.2-1.9-1.9-2.12.11.9-2.0-1.7-2.01.9-2.0-1.8-1.3-0.10.20.5
Delta distance traveled before/after self-admin1.21.32.7-1.3-1.2-1.31.11.6-0.9-1.3-1.10.5-1.4-1.7-1.20.50.80.7
Delta ambulatory time before/after self-admin1.01.13.1-1.0-1.2-1.30.81.4-0.6-0.9-1.2-0.0-1.2-1.8-0.71.50.30.3
Parametrial fat weight1.42.85.51.51.51.9-1.8-1.81.91.51.4-1.82.32.11.21.2-1.5-1.4
Pavlov. Cond. lever latency2.73.45.4-1.8-1.5-1.61.62.2-2.2-2.2-0.92.2-2.2-2.1-2.3-1.01.71.6
Pavlov. Cond. magazine entry latency8.110.515.23.73.53.5-3.5-3.73.83.92.8-3.73.73.63.50.5-1.3-1.3
Pavlov. Cond. change in total contacts7.47.911.73.43.43.4-3.4-3.33.33.13.1-3.42.92.62.2-0.40.30.5
Pavlov. Cond. index score6.98.812.93.33.03.0-2.9-3.53.43.62.2-3.43.43.33.40.9-1.7-1.7
Pavlov. Cond. latency score5.36.810.32.82.52.6-2.5-3.03.03.21.7-3.02.92.93.21.0-1.8-1.8
Pavlov. Cond. lever contacts2.42.84.91.61.31.4-1.3-1.91.92.00.7-1.81.92.02.21.0-1.8-1.8
Pavlov. Cond. magazine entry number10.112.618.1-4.2-4.0-3.93.84.1-4.1-4.3-3.24.1-3.9-3.9-3.7-0.41.21.1
Pavlov. Cond. intertrial magazine entries1.31.62.7-1.3-1.1-1.21.11.5-1.3-1.5-0.81.3-1.4-1.7-1.5-0.41.31.2
Pavlov. Cond. lever-magazine prob. diff.7.69.413.93.53.23.2-3.2-3.63.63.72.5-3.53.43.43.50.6-1.5-1.5
Pavlov. Cond. response bias7.69.213.03.63.43.4-3.3-3.63.63.62.8-3.53.33.33.10.2-0.9-0.9
Pavlov. Cond. lever latency0.30.50.7-0.6-0.6-0.70.50.7-0.6-0.7-0.70.6-0.8-0.9-0.6-0.70.80.6
Pavlov. Cond. magazine entry latency0.20.20.8-0.3-0.3-0.30.60.1-0.3-0.1-0.40.4-0.10.20.20.1-0.9-0.8
Pavlov. Cond. change in total contacts0.60.81.41.01.11.1-0.9-1.00.90.91.2-0.80.91.10.6-0.3-0.10.1
Pavlov. Cond. index score0.30.41.20.40.40.4-0.2-0.60.40.60.2-0.50.50.80.70.6-1.1-0.9
Pavlov. Cond. latency score0.20.21.10.30.20.2-0.0-0.40.20.40.1-0.20.40.70.60.5-1.1-0.9
Pavlov. Cond. lever contacts0.81.11.81.00.90.9-0.7-1.11.01.10.7-0.91.11.31.20.9-1.3-1.1
Pavlov. Cond. magazine entry number0.10.10.8-0.2-0.1-0.1-0.10.3-0.2-0.30.00.2-0.1-0.4-0.5-0.50.90.7
Pavlov. Cond. intertrial magazine entries1.92.44.8-1.2-0.9-1.11.01.7-1.6-1.7-0.51.7-1.6-1.7-2.0-1.42.22.0
Pavlov. Cond. lever-magazine prob. diff.0.20.31.20.20.20.2-0.1-0.50.30.40.1-0.30.40.70.50.6-1.1-0.9
Pavlov. Cond. response bias1.11.52.51.21.11.1-0.9-1.41.21.30.9-1.21.41.61.40.7-1.3-1.1
Time in closed arm before self-admin1.11.23.01.31.41.3-1.7-1.21.21.01.4-1.40.70.60.3-0.50.80.8
Time in closed arm after self-admin1.01.04.0-0.6-0.3-0.40.20.7-0.6-1.0-0.20.4-1.0-1.2-1.5-0.81.62.0
Time in open arm before self-admin1.92.15.0-1.7-1.6-1.42.01.8-1.8-1.6-1.42.2-1.0-0.9-1.2-0.40.3-0.2
Time in open arm after self-admin0.50.51.7-0.8-0.7-0.61.10.7-0.9-0.7-0.81.3-0.5-0.1-0.5-0.5-0.1-0.4
Bone: periosteal estimation0.40.81.9-0.9-1.1-1.00.90.6-0.8-0.5-1.40.7-0.4-0.30.10.9-1.3-1.2
Bone: periosteal perimeter0.71.22.7-1.3-1.4-1.31.20.9-1.1-0.9-1.61.1-0.7-0.5-0.30.7-1.3-1.1
Bone: post-yield work1.31.82.5-1.5-1.5-1.61.51.5-1.5-1.4-1.51.2-1.5-1.6-1.01.1-0.2-0.2
Progressive ratio test 1 active lever presses0.50.50.91.00.90.7-0.8-0.60.60.90.8-0.40.60.70.9-1.00.2-0.1
Progressive ratio test 1 breakpoint0.40.40.80.90.80.7-0.7-0.60.60.80.7-0.40.50.60.8-0.90.2-0.2
Progressive ratio test 1 inactive lever presses1.41.52.81.41.51.6-1.7-1.31.51.11.6-1.61.30.90.4-0.30.70.3
Progressive ratio test 2 active lever presses1.21.32.51.31.41.4-1.1-1.00.81.11.4-0.31.21.50.9-1.60.30.1
Progressive ratio test 2 breakpoint0.80.92.21.21.21.2-0.9-0.80.61.01.2-0.20.91.30.8-1.50.30.1
Progressive ratio test 2 inactive lever presses0.50.61.40.70.91.0-0.8-0.80.60.61.0-0.30.91.20.3-0.9-0.0-0.3
Incentive Sensitization - Responses1.31.32.81.31.31.4-1.0-1.10.91.21.2-0.51.31.71.0-1.3-0.1-0.2
Incentive Sensitization - Breakpoint1.21.22.81.31.31.3-1.0-1.10.81.21.2-0.41.31.71.1-1.2-0.2-0.3
Sum of active levers in priming session hrs 5-60.40.40.70.50.40.5-0.5-0.80.70.70.3-0.80.70.70.70.4-0.7-0.6
Progressive ratio0.10.20.50.20.10.2-0.2-0.70.50.30.2-0.30.70.50.4-0.5-0.4-0.1
Food seeking constrained by brief footshock0.30.30.60.40.30.4-0.7-0.10.70.60.1-0.70.70.60.70.6-0.8-0.7
Seeking ratio, punishment vs. effort0.00.10.20.10.1-0.1-0.10.5-0.20.2-0.10.1-0.4-0.20.20.40.2-0.0
Retroperitoneal fat weight0.10.31.3-0.5-0.6-0.30.2-0.0-0.1-0.4-0.7-0.2-0.1-0.3-0.41.1-0.8-0.7
Reaction time number correct0.81.23.0-1.2-1.2-1.11.60.9-1.4-0.9-1.21.7-0.8-0.0-0.5-0.3-1.4-0.9
Reaction time mean minus median0.20.30.6-0.5-0.5-0.60.70.6-0.4-0.5-0.50.1-0.7-0.8-0.40.40.40.6
Reaction time mean minus median AUC0.00.00.20.10.0-0.20.20.00.10.2-0.2-0.3-0.2-0.20.30.20.10.4
Reaction time num false alarms0.60.71.90.80.50.6-0.5-1.00.81.10.1-0.61.01.11.40.3-1.2-1.1
Reaction time num false alarms AUC0.50.61.70.60.40.5-0.3-0.80.70.90.1-0.50.91.01.30.4-1.3-1.2
Reaction time trials correct on left0.81.23.0-1.2-1.2-1.11.60.9-1.4-0.9-1.21.7-0.8-0.0-0.5-0.3-1.4-0.9
Reaction time trials on left0.81.22.9-1.1-1.1-1.11.60.9-1.4-0.9-1.11.7-0.80.0-0.5-0.3-1.4-0.9
Reaction time mean0.40.51.60.60.80.8-0.7-0.20.50.21.1-0.70.40.1-0.3-0.31.21.2
Reaction time mean AUC0.40.51.60.50.70.8-0.7-0.20.60.21.1-0.80.40.1-0.4-0.21.31.2
Median of all reaction times0.91.33.11.21.51.5-1.4-0.81.10.81.8-1.21.00.80.1-0.51.21.0
Reaction time omissions1.01.32.41.21.21.3-1.2-1.31.41.20.9-1.51.41.21.00.7-0.6-0.5
Reaction time false alarm rate0.71.01.81.10.90.9-1.1-1.11.31.30.6-1.31.20.81.30.5-0.4-0.6
Reaction time premature initiation rate0.40.51.90.60.70.7-0.4-0.20.70.60.8-0.60.90.70.51.4-0.8-0.7
Reaction time premature initiations0.30.41.9-0.3-0.2-0.10.70.5-0.3-0.20.00.50.10.4-0.01.2-1.4-1.1
Std. dev. reaction times0.00.00.20.00.0-0.00.10.10.1-0.00.1-0.3-0.1-0.2-0.10.30.40.5
Reaction time trials completed0.81.22.9-1.1-1.1-1.11.60.9-1.4-0.9-1.11.7-0.80.0-0.5-0.3-1.4-0.9
Reaction time trials AUC0.71.02.8-1.1-1.0-1.01.60.9-1.4-0.9-1.01.7-0.8-0.0-0.4-0.5-1.1-0.7
Run reversals in cocaine runway, females2.72.64.5-1.5-1.2-1.31.71.7-2.0-1.9-0.92.1-1.9-1.4-2.0-0.81.41.5
Run reversals in cocaine runway, males0.50.51.10.80.70.7-0.6-1.10.40.80.6-0.10.61.00.8-0.5-0.5-0.5
Latency to leave start box in cocaine runway1.31.42.5-1.5-1.4-1.21.40.8-1.4-1.6-1.31.6-1.2-0.8-1.5-0.60.1-0.0
Latency to leave start box in cocaine runway, F1.51.64.0-1.5-1.4-1.31.71.1-1.7-1.5-1.42.0-1.2-0.6-1.2-0.6-0.3-0.5
Latency to leave start box in cocaine runway, M0.50.41.10.30.50.7-0.9-0.90.7-0.00.7-1.00.30.0-0.7-0.40.80.8
Std. dev. time between licks in bursts0.10.10.8-0.4-0.4-0.30.10.1-0.1-0.3-0.4-0.00.0-0.2-0.10.9-0.5-0.6
Total sessions with >9 infusions0.70.81.71.01.11.0-1.1-1.31.00.71.0-1.10.60.40.3-0.51.00.6
Short access day 1 total inactive lever presses2.02.23.81.61.71.9-1.7-1.91.91.41.5-1.81.71.60.9-0.3-0.1-0.0
Short access day 10 total inactive lever presses0.20.32.0-0.4-0.4-0.10.10.20.3-0.5-0.1-0.7-0.0-0.4-0.71.4-0.00.3
Short access day 1 total infusions0.70.81.50.81.01.2-1.2-1.11.00.51.1-0.80.90.9-0.1-1.00.50.2
Short access day 10 total infusions0.30.41.00.60.60.7-0.5-0.60.40.60.6-0.10.81.00.6-0.2-0.7-0.8
Short access total infusions0.30.40.80.50.70.9-0.7-0.50.50.20.9-0.20.70.8-0.3-0.90.40.2
Short access day 1 locomotion3.33.66.22.12.22.3-2.5-2.22.41.92.1-2.52.01.71.1-0.30.4-0.1
Short access day 10 total locomotion1.11.22.11.41.31.2-1.2-1.31.01.41.1-0.71.21.11.4-0.3-0.1-0.3
Short access total locomotion0.60.60.90.80.90.9-0.9-0.90.80.50.9-0.70.60.50.1-0.90.90.7
One hour access (0.3 mA shock)0.10.11.10.10.20.10.10.2-0.2-0.10.30.4-0.00.2-0.2-1.00.50.4
Compulsive drug intake1.21.25.7-0.4-0.1-0.40.40.7-0.6-0.8-0.10.5-1.1-1.0-1.0-1.42.22.4
One hour access (shock baseline)0.40.41.20.50.50.6-0.5-0.60.40.60.5-0.10.91.10.6-0.1-0.9-1.1
Social response proportion0.20.30.7-0.5-0.6-0.80.60.5-0.4-0.3-0.80.1-0.8-0.7-0.00.2-0.20.1
Social responses0.30.41.30.1-0.1-0.0-0.2-0.40.60.4-0.4-0.80.30.30.70.9-1.2-0.9
Social time0.60.83.2-0.4-0.7-0.50.60.1-0.10.1-1.00.10.30.40.81.7-1.8-1.8
Soleus weight0.41.34.60.0-0.5-0.70.60.1-0.10.8-1.30.0-0.0-0.01.82.1-2.1-1.9
Bone: stiffness0.10.21.1-0.1-0.2-0.30.20.0-0.20.2-0.50.20.00.20.60.3-1.0-0.9
Tibialis anterior weight1.24.36.9-2.4-2.6-2.52.42.3-2.3-2.0-2.62.2-2.1-2.0-1.31.2-0.8-0.6
Time to tail flick, vehicle, before self-admin0.30.31.20.20.10.1-0.1-0.40.30.3-0.0-0.60.10.40.50.9-1.1-1.1
Time to tail flick, vehicle, after self-admin0.20.21.10.20.00.0-0.0-0.30.30.4-0.1-0.40.30.20.70.6-0.7-1.1
Time to tail flick, test, before self-admin1.41.43.2-1.2-1.2-1.31.41.8-1.3-1.2-1.11.4-1.2-1.3-0.80.90.1-0.1
Time to tail flick, test, after self-admin1.01.04.20.20.10.2-0.1-1.00.60.6-0.4-0.80.50.80.81.6-2.0-2.0
Delta time to tail flick, vehicle, before/after SA0.60.62.70.30.10.1-0.2-0.10.50.7-0.2-0.30.80.61.21.1-1.0-1.7
Delta time to tail flick, test, before/after SA2.82.56.01.61.51.5-1.5-2.41.71.71.0-1.81.51.91.5-0.0-1.3-1.2
Tibia length1.64.69.1-2.3-2.6-2.62.62.0-2.2-1.6-3.02.0-1.9-1.5-0.42.2-1.9-1.8
Ambulatory time before self-admin0.30.31.5-0.4-0.3-0.10.20.2-0.7-0.4-0.11.20.00.5-0.4-0.8-0.5-0.8
Ambulatory time after self-admin2.12.33.9-1.9-2.0-1.71.21.8-1.3-1.6-1.70.9-1.2-1.4-1.31.8-1.1-1.4
Bone: tissue strength0.90.81.4-0.9-0.9-1.11.11.0-1.0-0.9-0.90.8-1.2-1.2-0.61.0-0.20.3
Total heroin consumption2.32.76.71.11.01.4-1.0-1.31.31.51.0-1.02.12.51.51.4-2.4-2.6
Bone: trabecular number4.26.69.82.92.72.7-2.8-2.83.03.12.1-3.03.02.62.91.1-1.1-1.3
Bone: trabecular spacing1.41.84.2-1.6-1.8-1.71.81.2-1.5-1.1-2.11.5-1.2-0.6-0.30.4-1.0-1.2
Bone: trabecular thickness0.20.20.80.40.30.4-0.4-0.40.60.40.2-0.70.40.20.20.9-0.2-0.1
Bone: trabecular tissue density0.71.04.60.30.60.3-0.40.3-0.2-0.30.90.3-0.5-0.7-0.9-1.72.22.1
Water consumed over 24 hours0.20.21.0-0.3-0.3-0.30.40.3-0.3-0.1-0.40.2-0.3-0.20.11.0-0.7-0.7
Number of responses in last shaping day0.80.82.00.60.81.0-1.1-1.10.80.21.0-0.80.70.5-0.5-1.21.41.1