Hub : Genes

Zmat5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Zmat5	0.05	0.03	1.0e-04	0.01	0.04	0.03	0.03	2.5e-02	7.9e-05	3.7e-04	4.6e-04
2	Brain	alternative TSS	XM_006251427.4	0.03	0.02	7.5e-03	0.01	0.02	0.01	0	3.3e-02	5.9e-03	3.0e-02	2.5e-01
3	Brain	mRNA stability	Zmat5	0.04	0.03	2.0e-03	0.01	0.01	0.01	0	7.5e-02	2.5e-02	3.7e-02	1.6e-01
4	Liver	mRNA stability	Zmat5	0.04	0.03	1.1e-04	0.04	0.03	0.02	0.03	8.6e-05	2.1e-04	1.0e-03	1.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.9	1.2	1.1	0.8	0.9	-0.9
Area under the delay curve	0.8	0.8	2.1	-1.4	0.7	0.7	0.2
BMI with tail	0.0	0.0	0.1	-0.0	-0.3	-0.3	0.0
BMI without tail	0.5	1.0	1.1	0.9	1.0	1.0	-1.1
Body weight	0.4	1.5	2.5	-1.1	1.6	1.6	-0.3
Weight adjusted by age	1.1	1.2	1.9	0.2	1.4	1.4	-1.0
Bone surface	0.1	0.2	0.3	-0.1	0.6	0.6	-0.3
Bone volume	0.2	0.4	0.6	0.2	0.8	0.8	-0.6
Breakpoint value in progressive ratio session	0.4	0.5	1.1	-1.0	0.7	0.6	0.2
Number of licking bursts	1.0	1.1	2.0	-0.8	1.4	1.4	-0.2
Context. condit. distance diff. score	0.9	1.1	2.0	1.4	-1.0	-1.0	-0.3
Locomotion velocity, session 1	3.2	3.4	4.5	-1.5	-1.9	-1.9	2.1
Locomotion distance, session 1	0.6	0.8	1.5	1.2	0.5	0.5	-1.0
Locomotion velocity, session 2	2.8	3.2	3.8	-1.4	-1.9	-2.0	1.8
Locomotion distance, session 2	0.9	1.2	2.2	0.5	-1.5	-1.5	0.4
Locomotion velocity, session 3	0.8	0.9	2.6	1.6	-0.4	-0.4	-0.9
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.3
Stereotopy head waving bouts, day 3	0.3	0.3	0.8	0.9	-0.1	-0.1	-0.6
Stereotopy head waving duration, day 3	0.3	0.4	0.7	0.8	-0.7	-0.7	-0.0
Locomotion velocity, session 7	0.1	0.1	0.3	-0.5	-0.1	-0.1	0.2
Locomotion distance, session 7	0.3	0.4	0.6	0.0	-0.8	-0.8	0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.1
Stereotopy head waving duration, day 7	0.3	0.4	0.6	0.6	0.6	0.6	-0.8
Locomotion velocity, session 8	1.8	2.1	3.8	-0.1	-1.9	-2.0	1.0
Locomotion distance, session 8	1.9	2.8	4.4	2.1	-1.8	-1.8	-0.2
Degree of sensitization distance	0.8	0.8	1.3	0.4	-1.1	-1.1	0.9
Degree of sensitization stereotypy	0.1	0.1	0.2	0.0	0.4	0.5	-0.1
Conditioned locomotion	1.1	1.3	2.7	1.6	0.5	0.5	-1.4
Cocaine response after cond. corrected	0.6	0.7	1.1	-0.8	1.0	1.0	0.0
Cocaine response after cond. not corrected	1.2	1.3	2.4	-0.5	1.6	1.5	-0.5
Cocaine response before conditioning	0.2	0.2	0.4	0.7	0.2	0.2	-0.6
Saline control response	0.5	0.7	1.3	0.2	-1.1	-1.2	0.4
Bone: connectivity density	0.4	0.6	1.1	1.0	0.5	0.6	-0.8
Bone: cortical apparent density	0.3	0.4	0.6	-0.4	0.8	0.8	-0.1
Bone: cortical area	0.8	1.2	1.9	-1.2	1.4	1.3	-0.2
Bone: cortical porosity	0.5	0.5	0.8	0.5	0.8	0.9	-0.7
Bone: cortical porosity	0.2	0.2	0.4	0.7	0.3	0.3	-0.4
Bone: cortical thickness	1.3	2.1	3.6	-0.3	1.9	1.9	-1.1
Bone: cortical thickness	1.6	1.8	2.6	1.6	1.1	1.1	-1.5
Bone: cortical tissue density	0.2	0.3	0.5	-0.5	0.7	0.7	-0.0
Condit. Reinf. active minus inactive responses	1.5	1.7	2.6	-1.5	-1.0	-1.0	1.6
Condit. Reinf. active-inactive response ratio	5.2	5.7	7.1	-1.8	-2.5	-2.5	2.7
Condit. Reinf. active responses	0.5	0.6	0.9	-0.9	-0.6	-0.6	0.9
Condit. Reinf. inactive responses	1.0	1.1	1.5	0.6	1.2	1.2	-1.2
Incentive salience index mean	0.7	0.9	1.8	-1.3	-0.5	-0.6	1.1
Condit. Reinf. lever presses	0.0	0.1	0.1	-0.2	0.2	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.6	-0.5	-0.5	0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.0	-0.4	-0.4	0.4
Condit. Reinf. active responses	0.3	0.4	0.6	0.4	-0.8	-0.8	0.4
Condit. Reinf. inactive responses	0.4	0.4	0.7	0.3	-0.8	-0.8	0.5
Condit. Reinf. lever presses	0.2	0.2	0.6	0.8	-0.3	-0.3	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.5	-0.7	-0.7	0.3
Conditioned reinforcement - actives	0.4	0.4	0.4	-0.7	-0.6	-0.7	0.4
Conditioned reinforcement - inactives	0.2	0.2	0.3	-0.5	-0.4	-0.4	0.5
Conditioned locomotion	0.1	0.1	0.2	-0.1	0.4	0.4	-0.4
Patch foraging indifference point 0 sec	0.6	1.0	1.6	-0.9	1.3	1.2	-0.1
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.6	-0.2	-0.2	0.4
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.5	0.7	0.7	-0.2
Delay disc. indifference point, 16s delay	1.6	1.6	4.4	-2.1	-0.4	-0.4	1.3
Delay disc. indifference point, 2s delay	1.6	1.8	2.7	0.2	1.6	1.6	-1.3
Delay disc. indifference point, 24s delay	0.8	0.7	1.8	-1.4	-0.4	-0.4	0.9
Delay disc. indifference point, 4s delay	1.3	1.4	2.4	-0.7	1.5	1.5	-0.6
Delay disc. indifference point, 8s delay	0.3	0.4	1.2	-1.1	0.1	0.1	0.5
Indifference point function ln k	0.5	0.8	0.9	0.8	0.8	0.9	-0.9
Indifference point function log k	0.5	0.8	0.9	0.8	0.8	0.9	-0.9
Patch foraging total patch changes 0 sec	0.5	0.8	1.2	-1.1	1.0	1.0	0.1
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	-0.8	0.7	0.7	0.1
Patch foraging total patch changes 18 sec	1.6	2.0	4.3	-2.1	-0.6	-0.6	1.8
Patch foraging total patch changes 24 sec	0.9	1.1	1.6	-0.1	-1.3	-1.2	1.0
Patch foraging total patch changes 6 sec	0.4	0.5	1.5	-1.2	0.5	0.5	0.4
Patch foraging time to switch 0 sec	0.1	0.1	0.3	0.6	-0.2	-0.2	-0.2
Patch foraging water rate 0 sec	0.5	0.7	2.2	-1.5	0.3	0.2	0.8
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.0	0.1	0.1	-0.0
Patch foraging water rate 18 sec	2.6	3.5	4.2	1.6	2.0	2.1	-1.8
Patch foraging water rate 24 sec	0.5	0.7	1.2	-0.8	-0.7	-0.7	1.1
Patch foraging water rate 6 sec	0.3	0.5	0.9	-0.0	0.9	0.9	-0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	-0.0	-0.3	-0.3	0.2
Distance traveled before self-admin	1.4	1.4	2.0	0.5	1.4	1.4	-1.2
Distance traveled after self-admin	1.0	1.1	1.5	0.5	1.1	1.1	-1.2
Extensor digitorum longus weight	0.9	3.5	5.3	-1.8	2.3	2.3	-0.2
Bone: elastic displacement	1.0	1.1	1.9	1.4	0.8	0.8	-1.2
Bone: elastic work	1.7	2.2	2.8	1.1	1.6	1.7	-1.4
Bone: endosteal estimation	0.0	0.1	0.2	-0.3	0.4	0.4	0.0
Bone: endosteal perimeter	0.2	0.4	1.0	-1.0	0.4	0.4	0.3
Epididymis fat weight	0.6	1.5	2.7	1.5	0.6	0.7	-1.6
Delta time in closed arm before/after self-admin	1.5	1.5	4.5	2.1	-0.6	-0.5	-0.9
Delta time in open arm before/after self-admin	2.4	2.3	7.0	-2.6	0.8	0.7	1.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	0.5	0.2	0.3	-0.4
Delay discount exponential model param	0.7	0.7	1.7	1.3	-0.8	-0.7	-0.2
Extinction: sum of active levers before priming	0.9	0.9	1.5	-1.2	-0.8	-0.8	0.9
Active lever presses in extinction session 6	0.5	0.5	0.7	0.0	0.8	0.8	-0.7
Bone: final force	0.1	0.2	0.3	-0.3	0.5	0.5	-0.1
Bone: final moment	0.2	0.4	0.7	-0.3	0.8	0.8	-0.3
Food consumed during 24 hour testing period	1.4	1.7	3.9	-2.0	-0.6	-0.6	1.5
Glucose	16.3	24.5	49.4	-7.0	-2.8	-2.9	5.7
Heart weight	1.0	1.4	2.3	-0.2	-1.5	-1.5	1.1
Delay discount hyperbolic model param	0.7	0.7	1.6	1.2	-0.9	-0.8	-0.1
Intermittent access intake day 1-15 change	1.6	1.6	1.7	-1.3	-1.2	-1.3	1.3
Intermittent access intake escalation	1.2	1.2	1.3	-1.0	-1.1	-1.2	1.1
Intermittent access intake escalation 2	0.5	0.5	0.5	-0.6	-0.7	-0.7	0.7
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.0	0.5	-1.0	-0.9	0.6
Intermitt. access day 15 inactive lever presses	2.4	2.6	3.9	-1.7	-1.3	-1.3	2.0
Intermitt. access escalation Index	0.5	0.4	0.7	-0.5	-0.6	-0.5	0.9
Intermittent access day 1 total infusions	0.1	0.2	0.2	0.2	0.4	0.4	-0.5
Intermittent access day 15 total infusions	0.3	0.3	0.8	-0.9	-0.3	-0.3	0.5
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.6	-0.8	-0.2	-0.2	0.4
Intermittent access total infusions	0.1	0.1	0.1	-0.3	0.3	0.2	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.4	0.7	0.0	0.0	-0.3
Intermittent access day 15 total locomotion	0.5	0.6	1.0	-1.0	-0.5	-0.5	0.9
Intermittent access total locomotion	0.2	0.2	0.6	-0.8	-0.0	-0.0	0.4
Intermittent access standard deviation	0.3	0.3	0.6	0.8	-0.6	-0.6	-0.2
Left kidney weight	0.5	1.3	1.5	1.1	1.2	1.2	-1.0
Right kidney weight	1.2	3.4	6.0	2.5	1.4	1.5	-1.9
Cocaine induced anxiety	0.7	0.8	2.9	-1.7	0.3	0.2	0.6
Post-drug Anxiety	0.7	0.7	1.9	-1.4	-0.3	-0.4	0.9
Baseline Anxiety	0.8	0.9	1.3	-0.3	-1.1	-1.1	1.0
Tail length	2.0	6.0	10.7	0.3	3.2	3.3	-1.7
Length with tail	0.9	3.4	6.2	-1.1	2.5	2.5	-0.5
Length without tail	0.5	1.1	3.2	-1.8	0.0	-0.0	1.0
Times rat made contact with spout	3.3	3.8	4.2	-1.7	-2.0	-2.1	2.0
Lifetime Intake	0.2	0.3	0.4	-0.2	0.6	0.6	-0.5
Liver weight, left	2.5	4.0	6.9	2.6	1.6	1.7	-1.9
Liver weight, right	1.9	3.2	7.5	2.7	0.9	1.0	-1.9
Locomotor activity	0.6	1.0	2.1	-1.4	-0.4	-0.4	1.2
Locomotor testing distance	0.9	1.5	2.2	0.5	1.5	1.5	-1.2
Locomotor testing rearing	0.4	0.6	1.6	-1.3	0.6	0.6	0.2
Locomotion in novel chamber	1.2	1.5	4.4	2.1	-0.4	-0.3	-1.2
Locomotion in novel chamber post-restriction	2.6	3.1	5.4	0.3	-2.3	-2.3	1.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.1	-0.5	-0.5	0.3
Change in fecal boli incidents, locomotor task	1.0	0.9	1.3	-0.9	-0.9	-0.9	1.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.2
Bouts of movement, locomotor time 1	1.6	1.7	2.6	-1.5	-1.0	-1.0	1.6
Total resting periods, locomotor time 1	2.3	2.5	3.5	-1.5	-1.5	-1.5	1.9
Rest time, locomotor task time 1	0.8	0.8	1.1	-0.7	-0.9	-0.9	1.0
Distance moved, locomotor task time 1	1.2	1.4	1.8	0.6	1.3	1.4	-1.2
Vertical activity count, locomotor time 1	0.5	0.5	0.7	0.2	0.8	0.8	-0.7
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.3	-0.4	-0.4	0.4
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.1	0.2	0.2	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	0.1	0.0	0.2
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.3
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.2	-0.2	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.1	0.1	0.1	-0.1
Light reinforcement 1	0.5	0.9	1.3	0.3	1.0	1.0	-1.1
Light reinforcement 2	1.0	1.4	2.1	0.5	1.4	1.4	-1.1
Bone: marrow area	0.0	0.1	0.1	-0.3	0.3	0.3	0.1
Bone: maximum diameter	1.3	2.5	7.7	-2.8	0.3	0.2	1.4
Bone: maximum force	0.2	0.4	0.7	-0.1	0.9	0.8	-0.5
Bone: maximum moment	0.5	0.8	1.4	-0.0	1.2	1.2	-0.6
Mean time between licks in bursts	2.0	2.8	4.6	-1.8	-1.3	-1.3	2.1
Mean num. licks in bursts	3.3	4.0	6.8	-0.5	-2.6	-2.6	1.6
Cd content in liver	0.2	0.2	0.4	0.6	0.3	0.3	-0.6
Co content in liver	0.1	0.1	0.3	0.2	0.1	0.1	-0.5
Cu content in liver	0.1	0.1	0.3	-0.5	0.1	0.1	0.3
Fe content in liver	3.2	3.9	5.4	-1.0	-2.3	-2.3	1.9
K content in liver	2.6	2.5	3.6	0.5	1.9	1.8	-1.7
Mg content in liver	0.3	0.3	0.6	-0.1	0.5	0.5	-0.7
Mn content in liver	2.4	2.8	3.9	1.0	1.8	1.7	-2.0
Na content in liver	1.7	1.8	5.2	-2.3	-0.2	-0.3	1.3
Rb content in liver	1.3	1.6	2.7	-0.9	1.6	1.6	-0.7
Se content in liver	0.6	0.7	1.1	-0.6	1.0	1.0	-0.6
Sr content in liver	1.3	1.2	2.7	-1.6	-0.5	-0.5	1.3
Zn content in liver	0.2	0.2	0.3	-0.2	0.6	0.5	-0.5
Bone: minimum diameter	0.1	0.3	0.4	0.3	0.6	0.6	-0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.0	0.0	-0.3
Time in novel zone, hab. session 1	0.4	0.4	0.7	-0.1	0.8	0.8	-0.4
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.1	0.5	0.4	-0.4
Locomotion velocity, hab. session 1	0.0	0.1	0.1	-0.4	-0.2	-0.3	0.2
Time in familiar zone, hab. session 2	0.3	0.4	0.7	0.8	-0.6	-0.6	0.2
Time in novel zone, hab. session 2	0.5	0.5	0.8	-0.9	0.8	0.8	-0.3
Total zone transitions, hab. session 2	0.1	0.2	0.6	-0.8	0.2	0.2	0.1
Total locomotion distance, hab. session 2	0.3	0.4	1.3	-1.2	-0.2	-0.3	0.6
Locomotion velocity, hab. session 2	0.3	0.4	1.4	-1.2	-0.0	-0.1	0.5
Novel to familiar place preference ratio	1.2	1.2	2.4	-1.5	-0.7	-0.7	1.3
Novelty place preference	1.2	1.2	2.4	-1.5	-0.6	-0.7	1.3
Time in novel zone, NPP test	1.1	1.1	2.2	-1.5	-0.6	-0.6	1.2
Total zone transitions, NPP test	0.5	0.7	1.2	1.1	0.4	0.4	-1.1
Total locomotion distance, NPP test	0.1	0.1	0.3	0.5	0.2	0.1	-0.6
Locomotion velocity, NPP test	0.1	0.1	0.2	0.3	0.2	0.2	-0.4
Intraocular pressure	0.9	1.2	1.7	-1.3	-0.9	-0.9	1.3
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.2	-0.7	-0.7	0.3
Delta ambulatory time before/after self-admin	0.3	0.4	0.6	0.5	-0.8	-0.8	0.1
Parametrial fat weight	2.2	4.3	7.5	-2.7	-1.2	-1.2	2.6
Pavlov. Cond. lever latency	0.5	0.7	1.3	-1.1	-0.4	-0.4	1.0
Pavlov. Cond. magazine entry latency	0.6	0.8	2.0	1.4	-0.6	-0.6	-0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.5	-0.7	0.1	0.0	0.2
Pavlov. Cond. index score	0.7	0.9	2.4	1.6	-0.5	-0.5	-0.9
Pavlov. Cond. latency score	0.6	0.8	2.2	1.5	-0.3	-0.3	-0.8
Pavlov. Cond. lever contacts	0.4	0.4	1.1	1.0	-0.2	-0.2	-0.7
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	-1.2	1.0	1.0	0.4
Pavlov. Cond. intertrial magazine entries	1.4	1.8	3.0	0.4	1.7	1.7	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.7	1.7	-0.5	-0.5	-0.9
Pavlov. Cond. response bias	0.5	0.6	1.3	1.1	-0.5	-0.5	-0.8
Pavlov. Cond. lever latency	2.6	3.5	6.3	-0.6	2.5	2.5	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	0.1	0.1	-0.2
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	0.0	-0.7	-0.7	0.6
Pavlov. Cond. index score	0.6	0.8	1.4	0.6	-1.2	-1.1	0.4
Pavlov. Cond. latency score	0.5	0.6	1.0	0.7	-1.0	-1.0	0.2
Pavlov. Cond. lever contacts	2.1	2.9	5.0	0.5	-2.2	-2.2	1.2
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	0.1	0.6	0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.9	0.7	-0.9	-0.9	0.2
Pavlov. Cond. response bias	1.3	1.8	3.1	0.1	-1.8	-1.7	1.1
Time in closed arm before self-admin	0.7	0.7	1.3	0.0	1.2	1.1	-0.6
Time in closed arm after self-admin	1.0	1.0	3.0	1.7	0.2	0.2	-1.0
Time in open arm before self-admin	0.8	0.8	1.3	1.0	-1.1	-1.1	-0.1
Time in open arm after self-admin	1.8	2.0	2.7	-1.6	-1.2	-1.2	1.6
Bone: periosteal estimation	0.4	0.7	1.1	-0.9	1.0	1.0	-0.1
Bone: periosteal perimeter	0.5	0.8	1.5	-1.2	0.9	0.9	0.2
Bone: post-yield work	0.0	0.1	0.1	-0.4	0.2	0.2	-0.0
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	-0.6	-0.4	-0.4	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.2
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.4	-1.2	0.4	0.4	0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	-0.5	-0.1	-0.1	0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.7	-0.3	-0.3	0.2
Progressive ratio test 2 inactive lever presses	1.2	1.4	2.5	-1.6	-0.8	-0.9	1.2
Incentive Sensitization - Responses	0.3	0.3	0.3	-0.6	-0.5	-0.5	0.6
Incentive Sensitization - Breakpoint	0.3	0.3	0.3	-0.5	-0.5	-0.5	0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.5	0.1	0.1	0.0
Progressive ratio	0.2	0.2	0.4	0.4	0.4	0.4	-0.6
Food seeking constrained by brief footshock	3.0	3.6	5.8	0.3	2.4	2.4	-1.7
Seeking ratio, punishment vs. effort	0.4	0.5	0.9	-0.3	0.9	0.9	-0.3
Retroperitoneal fat weight	0.2	0.5	0.7	-0.4	-0.8	-0.9	0.7
Reaction time number correct	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.6
Reaction time mean minus median	1.9	2.5	4.4	-0.0	-2.1	-2.0	1.2
Reaction time mean minus median AUC	0.6	0.8	1.5	0.4	-1.2	-1.2	0.2
Reaction time num false alarms	0.6	0.9	1.3	0.5	1.0	1.0	-1.2
Reaction time num false alarms AUC	1.2	1.7	2.4	0.9	1.3	1.3	-1.6
Reaction time trials correct on left	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.6
Reaction time trials on left	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.6
Reaction time mean	0.5	0.7	1.3	0.3	-1.1	-1.1	0.5
Reaction time mean AUC	0.4	0.6	1.0	0.6	-1.0	-1.0	0.2
Median of all reaction times	0.2	0.3	0.5	0.3	-0.7	-0.7	0.3
Reaction time omissions	0.4	0.5	1.0	1.0	-0.7	-0.7	-0.3
Reaction time false alarm rate	1.8	2.6	3.3	1.2	1.7	1.7	-1.8
Reaction time premature initiation rate	1.4	1.9	5.1	2.3	0.3	0.3	-1.5
Reaction time premature initiations	0.5	0.8	2.2	1.5	-0.0	-0.1	-0.9
Std. dev. reaction times	1.5	2.1	3.8	-0.0	-1.9	-1.9	1.1
Reaction time trials completed	0.3	0.4	0.5	-0.6	-0.7	-0.7	0.6
Reaction time trials AUC	0.2	0.3	0.4	-0.6	-0.5	-0.5	0.6
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.5	-0.7	-0.7	0.1
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.3	0.6	0.6	-0.1
Latency to leave start box in cocaine runway	0.4	0.5	0.7	0.5	0.7	0.7	-0.8
Latency to leave start box in cocaine runway, F	1.0	1.1	1.6	0.4	1.3	1.3	-1.0
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.3	-0.5	-0.5	0.0
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.1	-0.3	-0.2	0.5
Total sessions with >9 infusions	0.6	0.6	1.2	0.5	0.8	0.7	-1.1
Short access day 1 total inactive lever presses	1.7	1.9	3.3	-0.8	1.8	1.8	-0.7
Short access day 10 total inactive lever presses	0.1	0.2	0.6	0.8	-0.1	-0.0	-0.1
Short access day 1 total infusions	1.0	1.0	1.8	0.9	0.9	0.9	-1.3
Short access day 10 total infusions	0.6	0.6	0.9	0.6	0.8	0.8	-0.9
Short access total infusions	1.3	1.5	2.3	1.0	1.1	1.1	-1.5
Short access day 1 locomotion	2.8	3.0	4.8	2.0	1.2	1.3	-2.2
Short access day 10 total locomotion	0.7	0.8	1.0	1.0	0.7	0.7	-1.0
Short access total locomotion	2.3	2.4	4.6	2.1	0.8	0.8	-1.9
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.4	0.1	0.0	-0.2
Compulsive drug intake	0.7	0.7	2.2	1.5	-0.3	-0.3	-0.6
One hour access (shock baseline)	0.4	0.5	1.9	-1.4	0.0	-0.0	0.4
Social response proportion	2.7	2.9	4.5	-2.1	-1.2	-1.2	2.0
Social responses	2.0	2.6	5.1	-2.3	-0.9	-1.0	1.9
Social time	0.8	1.1	1.6	-1.0	-0.9	-0.9	1.3
Soleus weight	0.9	2.7	5.0	-0.0	2.2	2.2	-1.0
Bone: stiffness	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.1
Tibialis anterior weight	0.2	0.8	2.2	-1.5	0.6	0.6	0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.4	0.2	0.2	-0.3
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	0.6	0.5	0.6	-0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.6	-0.0	-0.0	-0.3
Time to tail flick, test, after self-admin	1.5	1.5	2.8	-0.4	1.7	1.6	-0.7
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.0	0.2	0.2	-0.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.7	-0.8	0.4	0.4	0.3
Tibia length	1.0	2.9	3.4	1.5	1.8	1.8	-1.7
Ambulatory time before self-admin	2.8	2.9	4.2	0.6	2.1	2.0	-1.7
Ambulatory time after self-admin	0.9	1.0	1.3	0.4	1.1	1.1	-1.1
Bone: tissue strength	0.1	0.1	0.3	-0.3	-0.1	-0.1	0.5
Total heroin consumption	0.1	0.1	0.1	-0.2	0.3	0.3	0.0
Bone: trabecular number	0.7	1.1	1.2	1.0	1.1	1.1	-1.0
Bone: trabecular spacing	0.5	0.6	1.9	-1.4	-0.2	-0.2	0.7
Bone: trabecular thickness	1.3	1.6	3.4	1.8	0.7	0.8	-1.3
Bone: trabecular tissue density	1.2	1.6	2.3	-0.6	-1.5	-1.5	1.3
Water consumed over 24 hours	1.2	1.5	3.0	-1.7	-0.6	-0.7	1.4
Number of responses in last shaping day	0.4	0.4	1.0	0.4	0.5	0.4	-1.0