Hub : Genes

Zfyve9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr5_128668858_128672853 0.04 0.03 1.3e-04 0.02 0.02 0.02 0.02 6.0e-04 2.8e-04 2.7e-04 6.3e-04
2 Adipose mRNA stability Zfyve9 0.06 0.05 1.3e-03 0.02 0.02 0.03 0.03 1.6e-03 1.6e-03 4.0e-04 1.7e-04
3 NAcc isoform ratio XM_063287712.1 0.03 0.02 7.2e-05 0.03 0.03 0.02 0.03 7.2e-05 2.3e-05 9.0e-04 3.2e-05
4 IC isoform ratio XM_063287712.1 0.1 0.08 4.9e-03 0.04 0.02 0.04 0.03 5.9e-03 4.0e-02 9.0e-03 2.0e-02
5 PL gene expression Zfyve9 0.04 0.03 2.4e-04 0.02 0.02 0.02 0.02 2.5e-03 6.6e-03 1.4e-03 2.8e-03
6 Brain gene expression Zfyve9 0.03 0.03 6.8e-03 0.02 0 0 0.01 5.9e-03 1.0e-01 1.6e-01 2.8e-02
7 PL isoform ratio XM_063287712.1 0.05 0.04 1.1e-05 0.05 0.04 0.05 0.05 2.7e-06 1.2e-05 6.0e-06 3.9e-06
8 PL intron excision ratio chr5_128668858_128672853 0.06 0.04 3.5e-06 0.05 0.05 0.05 0.05 2.5e-06 8.2e-06 2.9e-06 5.0e-06
9 Brain alternative polyA NM_001107952.1 0.02 0.02 9.3e-03 0.01 0.01 0.01 0.01 2.8e-02 3.4e-02 4.4e-02 4.7e-02
10 Brain alternative polyA NM_001107952.1 0.02 0.02 8.6e-03 0.02 0.01 0.01 0.01 7.2e-03 3.6e-02 3.9e-02 5.7e-02
11 NAcc gene expression Zfyve9 0.04 0.03 7.2e-06 0.04 0.03 0.03 0.03 1.2e-06 5.1e-05 9.5e-06 7.4e-06
12 IC alternative polyA XM_063287713.1 0.14 0.1 1.4e-03 0.04 0.05 0.03 0.06 7.0e-03 3.4e-03 2.4e-02 2.1e-03
13 IC alternative polyA XM_063287713.1 0.12 0.09 3.0e-03 0.04 0.05 0.02 0.05 8.4e-03 3.3e-03 4.5e-02 5.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.50.91.40.40.41.01.2-1.2-1.01.11.0-1.1-1.1-1.01.10.7
Area under the delay curve0.10.20.80.7-0.90.30.10.0-0.3-0.1-0.00.00.00.00.0-0.7
BMI with tail1.44.76.9-2.30.6-2.6-2.62.42.6-2.1-2.62.02.02.4-2.1-0.2
BMI without tail0.72.13.0-1.4-0.1-1.7-1.71.61.7-1.5-1.71.51.51.6-1.5-0.4
Body weight0.73.24.6-1.90.4-2.1-2.12.02.1-1.8-2.11.71.72.0-1.7-0.3
Weight adjusted by age0.30.51.2-1.11.0-0.9-1.00.70.6-0.4-0.60.30.30.6-0.30.6
Bone surface0.20.41.10.5-0.00.71.0-0.8-0.70.50.7-0.5-0.5-0.70.5-0.0
Bone volume0.00.00.20.00.10.20.4-0.3-0.20.20.2-0.2-0.2-0.20.20.1
Breakpoint value in progressive ratio session0.00.00.1-0.10.40.00.2-0.2-0.20.30.2-0.1-0.1-0.10.10.2
Number of licking bursts0.20.31.4-1.21.1-0.6-0.40.20.5-0.2-0.50.20.20.5-0.20.6
Context. condit. distance diff. score0.40.51.1-0.21.00.5-0.1-0.5-0.50.80.8-0.8-0.8-0.80.80.8
Locomotion velocity, session 13.13.44.70.41.31.61.7-2.1-1.82.21.9-2.2-2.2-1.92.21.7
Locomotion distance, session 10.10.20.9-0.60.90.10.0-0.3-0.10.40.2-0.4-0.4-0.20.40.7
Locomotion velocity, session 22.93.34.80.31.61.61.5-2.0-1.82.21.8-2.2-2.2-1.82.21.8
Locomotion distance, session 20.70.91.6-0.1-0.7-0.6-0.40.90.9-1.3-0.71.31.30.7-1.3-1.2
Locomotion velocity, session 30.70.81.50.50.71.01.2-1.2-0.90.91.1-0.9-0.9-1.10.90.5
Locomotion distance, session 30.20.20.80.4-0.7-0.0-0.20.40.2-0.6-0.10.60.60.1-0.6-0.9
Stereotopy head waving bouts, day 30.20.21.4-0.61.20.00.6-0.50.00.3-0.0-0.3-0.30.00.30.7
Stereotopy head waving duration, day 30.81.03.0-0.81.70.30.8-1.0-0.31.00.3-1.0-1.0-0.31.01.7
Locomotion velocity, session 70.30.31.10.9-0.40.6-0.60.3-0.3-0.30.70.30.3-0.7-0.3-1.0
Locomotion distance, session 70.91.24.51.5-1.90.6-0.60.7-0.3-0.90.50.90.9-0.5-0.9-2.1
Stereotopy head waving bouts, day 71.71.92.80.31.41.31.5-1.7-1.21.51.3-1.5-1.5-1.31.51.3
Stereotopy head waving duration, day 71.72.13.10.31.31.31.6-1.8-1.21.61.3-1.6-1.6-1.31.61.5
Locomotion velocity, session 81.61.93.00.80.81.50.7-1.3-1.61.51.7-1.5-1.5-1.71.50.8
Locomotion distance, session 80.00.10.20.00.30.2-0.50.1-0.1-0.00.40.00.0-0.4-0.0-0.1
Degree of sensitization distance0.30.30.70.2-0.6-0.1-0.80.70.1-0.5-0.10.50.50.1-0.5-0.8
Degree of sensitization stereotypy0.80.91.30.40.81.01.1-1.2-0.81.01.0-1.0-1.0-1.01.00.8
Conditioned locomotion0.40.41.5-1.20.9-0.5-0.90.30.40.2-0.4-0.2-0.20.40.21.1
Cocaine response after cond. corrected2.02.43.8-0.3-1.4-1.3-0.71.51.5-2.0-1.52.02.01.5-2.0-1.7
Cocaine response after cond. not corrected2.42.84.1-0.7-1.2-1.6-1.11.71.8-2.0-1.82.02.01.8-2.0-1.4
Cocaine response before conditioning0.10.10.4-0.60.5-0.4-0.60.20.30.1-0.3-0.1-0.10.30.10.6
Saline control response0.70.93.41.2-1.50.4-0.60.8-0.1-0.90.10.90.9-0.1-0.9-1.9
Bone: connectivity density1.01.53.51.0-0.11.41.9-1.5-1.41.11.4-1.1-1.1-1.41.10.2
Bone: cortical apparent density1.82.43.60.60.71.51.2-1.7-1.61.91.6-1.9-1.9-1.61.91.4
Bone: cortical area1.21.93.2-0.6-0.5-1.3-1.81.71.3-1.5-1.41.51.51.4-1.5-1.0
Bone: cortical porosity1.01.13.7-1.41.9-0.3-0.1-0.5-0.01.0-0.1-1.0-1.00.11.01.9
Bone: cortical porosity1.11.23.6-1.01.90.20.1-0.8-0.41.30.3-1.3-1.3-0.31.31.9
Bone: cortical thickness2.54.17.8-1.60.0-2.2-2.82.52.2-2.0-2.22.02.02.2-2.0-0.7
Bone: cortical thickness1.92.35.2-1.70.7-1.8-2.31.81.6-1.2-1.71.21.21.7-1.20.1
Bone: cortical tissue density2.02.74.10.60.81.61.3-1.8-1.72.01.7-2.0-2.0-1.72.01.5
Condit. Reinf. active minus inactive responses0.50.50.7-0.7-0.3-0.8-0.50.70.8-0.8-0.80.80.80.8-0.8-0.4
Condit. Reinf. active-inactive response ratio0.70.70.9-0.8-0.1-0.9-0.80.90.9-0.9-0.90.90.90.9-0.9-0.4
Condit. Reinf. active responses1.01.21.6-1.0-0.2-1.2-0.91.21.2-1.2-1.31.21.21.3-1.2-0.6
Condit. Reinf. inactive responses0.10.10.30.1-0.5-0.3-0.40.50.2-0.4-0.20.40.40.2-0.4-0.6
Incentive salience index mean1.51.82.5-1.4-0.2-1.5-1.11.41.6-1.5-1.61.51.51.6-1.5-0.6
Condit. Reinf. lever presses1.52.12.9-1.4-0.0-1.7-1.31.51.7-1.6-1.71.61.61.7-1.6-0.6
Condit. Reinf. active minus inactive responses0.81.02.30.7-1.5-0.2-1.31.20.4-1.1-0.41.11.10.4-1.1-1.5
Condit. Reinf. active-inactive response ratio0.30.41.30.7-1.20.1-0.60.60.0-0.5-0.00.50.50.0-0.5-1.0
Condit. Reinf. active responses0.40.51.20.1-0.9-0.4-1.11.00.5-0.8-0.50.80.80.5-0.8-0.9
Condit. Reinf. inactive responses0.30.30.6-0.70.1-0.7-0.60.60.7-0.5-0.70.50.50.7-0.50.1
Condit. Reinf. lever presses0.60.83.71.4-1.90.81.0-0.3-0.6-0.30.60.30.3-0.6-0.3-1.4
Condit. Reinf. lever reinforcers received0.40.51.10.4-1.0-0.2-0.80.80.3-0.8-0.30.80.80.3-0.8-1.1
Conditioned reinforcement - actives2.13.65.2-0.1-2.0-1.4-1.62.11.8-2.3-1.82.22.21.7-2.2-2.2
Conditioned reinforcement - inactives0.10.10.1-0.30.0-0.3-0.30.40.3-0.3-0.40.20.20.3-0.3-0.1
Conditioned locomotion1.01.32.0-0.2-1.0-0.9-1.01.21.2-1.4-1.21.41.41.0-1.2-1.1
Patch foraging indifference point 0 sec0.30.60.8-0.4-0.5-0.7-0.80.90.8-0.8-0.70.80.80.8-0.8-0.5
Patch foraging indifference point AUC0.20.20.30.40.00.60.6-0.6-0.50.50.6-0.4-0.4-0.60.50.2
Delay disc. indifference point, 0s delay0.50.51.61.2-1.20.80.6-0.4-0.70.30.3-0.5-0.5-0.30.4-0.8
Delay disc. indifference point, 16s delay1.01.11.6-0.5-0.5-1.0-0.91.10.9-1.2-1.31.21.21.2-1.1-0.8
Delay disc. indifference point, 2s delay0.10.10.20.5-0.40.3-0.0-0.1-0.30.40.1-0.4-0.4-0.10.4-0.2
Delay disc. indifference point, 24s delay0.10.20.40.7-0.40.5-0.1-0.1-0.60.30.3-0.1-0.1-0.50.4-0.2
Delay disc. indifference point, 4s delay0.00.10.20.2-0.4-0.0-0.20.2-0.0-0.2-0.20.10.10.2-0.2-0.4
Delay disc. indifference point, 8s delay0.10.10.50.5-0.70.20.00.1-0.1-0.2-0.20.20.20.0-0.1-0.6
Indifference point function ln k0.30.50.7-0.6-0.1-0.8-0.80.90.8-0.8-0.80.80.80.8-0.8-0.4
Indifference point function log k0.30.50.7-0.6-0.1-0.8-0.80.90.8-0.8-0.80.80.80.8-0.8-0.4
Patch foraging total patch changes 0 sec0.20.50.6-0.5-0.3-0.7-0.80.80.7-0.7-0.70.70.70.7-0.7-0.4
Patch foraging total patch changes 12 sec0.91.11.50.8-0.41.21.2-1.2-1.21.11.2-1.1-1.1-1.21.10.4
Patch foraging total patch changes 18 sec0.20.30.5-0.50.1-0.6-0.60.70.7-0.7-0.60.70.70.5-0.7-0.3
Patch foraging total patch changes 24 sec0.61.11.6-0.90.0-1.2-1.21.21.2-1.0-1.11.11.11.2-1.0-0.2
Patch foraging total patch changes 6 sec0.20.31.10.5-1.1-0.1-0.20.50.2-0.6-0.10.60.60.2-0.6-1.0
Patch foraging time to switch 0 sec0.81.72.40.60.61.31.4-1.5-1.41.51.3-1.5-1.5-1.41.51.1
Patch foraging water rate 0 sec1.22.63.6-1.40.1-1.9-1.91.91.9-1.7-1.81.61.61.9-1.6-0.5
Patch foraging water rate 12 sec1.63.44.8-1.1-0.5-1.9-2.02.22.0-2.1-2.02.12.11.9-2.0-1.1
Patch foraging water rate 18 sec0.10.10.3-0.40.5-0.1-0.0-0.2-0.10.30.0-0.3-0.30.00.30.6
Patch foraging water rate 24 sec0.10.10.5-0.70.6-0.3-0.30.10.20.1-0.1-0.1-0.10.20.10.6
Patch foraging water rate 6 sec1.11.62.4-1.1-0.1-1.4-1.41.41.4-1.3-1.51.31.31.3-1.3-0.4
Seeking ratio, delayed vs. immediate footshock2.53.14.3-1.0-0.4-1.7-1.82.02.0-2.1-1.92.12.11.8-2.0-1.2
Distance traveled before self-admin0.20.31.6-0.71.3-0.6-0.10.10.4-0.1-0.4-0.1-0.10.50.00.4
Distance traveled after self-admin0.70.81.6-1.00.9-1.3-0.90.91.1-0.8-1.10.70.71.2-0.8-0.1
Extensor digitorum longus weight1.04.16.5-2.61.8-2.4-2.32.02.4-1.7-2.31.71.72.3-1.70.2
Bone: elastic displacement0.30.31.2-1.11.0-0.50.0-0.20.40.3-0.3-0.3-0.30.30.31.1
Bone: elastic work0.10.10.4-0.70.1-0.5-0.40.30.5-0.2-0.40.20.20.4-0.20.2
Bone: endosteal estimation0.10.31.70.6-0.10.41.3-0.7-0.50.30.3-0.3-0.3-0.30.3-0.1
Bone: endosteal perimeter0.30.72.81.4-0.90.91.7-0.8-0.80.20.7-0.2-0.2-0.70.2-0.8
Epididymis fat weight0.10.31.01.0-0.80.70.6-0.4-0.60.20.4-0.2-0.2-0.70.1-0.6
Delta time in closed arm before/after self-admin0.00.00.20.2-0.40.1-0.10.10.0-0.1-0.00.10.10.0-0.1-0.3
Delta time in open arm before/after self-admin0.10.10.2-0.1-0.2-0.30.30.10.4-0.4-0.40.40.40.4-0.4-0.4
Diff in mean of infusions in LGA sessions0.20.31.00.7-1.00.1-0.40.40.1-0.3-0.10.40.40.1-0.4-1.0
Delay discount exponential model param0.10.20.8-0.70.9-0.3-0.0-0.10.20.10.1-0.1-0.10.00.00.7
Extinction: sum of active levers before priming0.50.52.7-1.31.6-0.7-0.10.00.40.1-0.40.10.10.4-0.11.2
Active lever presses in extinction session 61.61.52.1-0.1-0.7-1.1-1.11.41.2-1.3-1.21.51.51.4-1.5-1.4
Bone: final force0.00.10.20.5-0.20.30.3-0.1-0.3-0.00.20.00.0-0.2-0.0-0.5
Bone: final moment0.00.10.40.4-0.40.10.10.1-0.1-0.2-0.00.20.20.0-0.2-0.6
Food consumed during 24 hour testing period1.11.55.41.1-1.9-0.1-0.31.00.3-1.4-0.31.41.40.3-1.4-2.3
Glucose0.20.30.90.3-0.2-0.2-0.30.60.3-0.7-0.30.80.80.3-0.8-0.9
Heart weight1.32.04.2-2.11.1-1.9-1.81.41.6-1.0-1.51.01.01.6-1.00.6
Delay discount hyperbolic model param0.10.10.6-0.70.8-0.3-0.0-0.00.3-0.00.00.10.10.1-0.10.6
Intermittent access intake day 1-15 change0.51.12.0-0.2-0.9-0.7-0.81.01.0-1.2-0.91.41.40.9-1.2-1.0
Intermittent access intake escalation0.51.01.8-0.5-0.5-0.8-0.91.01.0-1.1-1.01.31.30.9-1.2-0.7
Intermittent access intake escalation 20.30.30.8-0.2-0.3-0.4-0.40.50.6-0.6-0.50.90.90.4-0.7-0.4
Intermitt. access day 1 inactive lever presses0.51.92.6-0.7-0.6-1.4-1.51.61.4-1.5-1.41.51.51.4-1.6-1.0
Intermitt. access day 15 inactive lever presses0.40.71.2-1.10.6-1.1-1.11.00.9-0.8-1.00.70.71.0-0.80.1
Intermitt. access escalation Index0.20.30.9-0.40.9-0.10.0-0.3-0.30.60.3-0.7-0.7-0.10.50.8
Intermittent access day 1 total infusions0.10.20.8-0.50.9-0.10.0-0.2-0.00.30.0-0.5-0.5-0.10.30.8
Intermittent access day 15 total infusions0.30.50.8-0.90.5-0.8-0.80.70.8-0.6-0.80.60.60.7-0.70.1
Intermittent access terminal intake (last 3 days)0.10.10.3-0.50.4-0.3-0.30.30.4-0.3-0.40.30.30.2-0.30.2
Intermittent access total infusions0.10.10.6-0.60.8-0.2-0.20.00.20.1-0.1-0.1-0.10.10.10.6
Intermittent access day 1 locomotion0.10.10.3-0.40.6-0.1-0.1-0.10.10.1-0.0-0.2-0.20.00.10.5
Intermittent access day 15 total locomotion0.20.40.70.1-0.8-0.3-0.40.60.6-0.8-0.50.70.70.4-0.7-0.8
Intermittent access total locomotion0.10.10.4-0.60.7-0.3-0.20.10.3-0.1-0.30.10.10.2-0.00.5
Intermittent access standard deviation1.53.14.5-1.1-0.5-1.8-1.92.01.9-2.0-1.82.12.11.8-2.0-1.0
Left kidney weight4.822.529.9-3.6-0.7-5.2-5.35.55.2-5.1-5.25.25.25.2-5.1-2.3
Right kidney weight2.913.317.1-3.20.1-4.1-4.14.14.1-3.8-4.14.04.04.0-3.9-1.4
Cocaine induced anxiety0.81.23.0-1.71.7-1.3-1.21.00.8-0.7-0.90.70.70.8-0.90.9
Post-drug Anxiety1.61.75.0-2.22.2-1.7-1.51.10.9-0.7-0.90.70.71.0-0.81.2
Baseline Anxiety0.00.00.2-0.1-0.0-0.4-0.40.30.1-0.1-0.10.00.00.4-0.0-0.2
Tail length0.00.00.1-0.1-0.30.10.1-0.1-0.00.00.10.10.1-0.10.00.1
Length with tail0.10.60.9-0.4-0.5-0.8-0.81.00.8-0.9-0.81.01.00.8-0.9-0.6
Length without tail1.34.36.0-0.9-0.9-2.0-2.12.42.1-2.4-2.12.42.42.1-2.4-1.7
Times rat made contact with spout0.81.03.30.4-1.1-0.30.30.60.5-1.3-0.51.31.30.5-1.3-1.8
Lifetime Intake0.00.00.0-0.10.1-0.0-0.00.00.1-0.0-0.0-0.1-0.1-0.00.00.1
Liver weight, left0.10.20.50.7-0.60.50.5-0.2-0.4-0.00.50.10.1-0.5-0.0-0.6
Liver weight, right0.10.20.60.8-0.60.70.6-0.3-0.40.00.50.00.0-0.5-0.0-0.6
Locomotor activity0.60.95.01.1-2.20.20.00.4-0.0-0.70.20.70.70.1-0.7-1.7
Locomotor testing distance0.81.45.90.9-2.4-0.2-0.40.90.4-1.2-0.11.21.20.5-1.2-2.0
Locomotor testing rearing0.71.55.91.5-2.40.2-0.10.80.1-1.1-0.11.11.10.2-1.1-2.3
Locomotion in novel chamber3.03.85.6-0.4-1.7-1.7-1.21.92.0-2.3-2.02.32.32.0-2.4-2.0
Locomotion in novel chamber post-restriction0.40.62.3-1.51.5-0.9-0.10.10.6-0.1-0.50.20.20.6-0.11.1
Fecal boli incidents, locomotor time 10.20.31.60.8-1.20.2-0.40.40.0-0.3-0.20.10.10.0-0.3-1.0
Change in fecal boli incidents, locomotor task0.30.30.50.6-0.20.70.5-0.5-0.50.50.6-0.5-0.5-0.60.60.0
Time >=10cm from walls, locomotor time 11.51.52.7-0.31.60.71.5-1.5-1.01.31.0-1.3-1.3-1.01.21.7
Bouts of movement, locomotor time 10.81.02.91.0-0.51.11.7-1.2-0.90.81.1-0.8-0.8-1.00.8-0.1
Total resting periods, locomotor time 10.60.62.20.7-0.20.91.5-1.0-0.70.61.0-0.6-0.6-0.80.70.1
Rest time, locomotor task time 10.10.20.70.7-0.80.50.2-0.1-0.20.00.30.10.1-0.40.1-0.6
Distance moved, locomotor task time 10.40.62.3-0.81.5-0.1-0.1-0.4-0.30.60.4-0.9-0.9-0.10.71.3
Vertical activity count, locomotor time 10.10.41.1-0.60.2-0.7-1.00.80.6-0.6-0.50.40.40.7-0.6-0.1
Time >=10cm from walls, locomotor time 20.10.10.8-0.50.9-0.2-0.2-0.10.00.1-0.0-0.0-0.00.00.20.7
Bouts of movement, locomotor time 20.50.81.5-0.31.20.51.2-1.1-0.40.90.6-0.9-0.9-0.90.91.2
Total resting periods, locomotor time 20.40.71.6-0.21.00.51.3-1.1-0.40.80.6-0.9-0.9-0.90.91.1
Rest time, locomotor task time 20.20.20.60.8-0.80.60.5-0.3-0.30.00.1-0.3-0.3-0.60.3-0.5
Distance moved, locomotor task time 20.70.81.7-1.20.8-1.1-1.31.01.0-0.7-0.80.50.51.1-0.60.3
Vertical activity count, locomotor time 21.41.93.4-0.9-0.4-1.4-1.81.81.5-1.6-1.31.31.31.5-1.6-0.8
Light reinforcement 10.10.30.9-0.90.5-0.7-0.60.40.5-0.1-0.50.10.10.5-0.10.6
Light reinforcement 21.01.52.3-1.40.3-1.5-1.51.31.4-1.1-1.51.11.11.5-1.00.0
Bone: marrow area0.10.31.80.5-0.10.31.3-0.7-0.40.30.2-0.3-0.3-0.20.3-0.1
Bone: maximum diameter0.10.10.3-0.40.2-0.5-0.20.30.4-0.3-0.60.30.30.6-0.30.1
Bone: maximum force0.00.00.20.4-0.30.10.20.0-0.2-0.1-0.00.10.10.0-0.1-0.5
Bone: maximum moment0.00.10.30.4-0.4-0.00.00.2-0.0-0.3-0.20.30.30.2-0.3-0.6
Mean time between licks in bursts0.71.84.12.0-1.41.80.9-0.9-1.61.01.6-1.0-1.0-1.61.0-0.5
Mean num. licks in bursts0.50.82.30.7-1.4-0.20.00.60.4-1.0-0.41.01.00.4-1.0-1.5
Cd content in liver0.50.50.80.8-0.00.90.4-0.6-0.90.70.9-0.7-0.7-0.90.70.1
Co content in liver0.10.10.20.5-0.40.20.1-0.0-0.2-0.10.20.10.1-0.2-0.1-0.5
Cu content in liver0.91.13.61.9-1.91.00.9-0.2-0.7-0.40.70.40.4-0.7-0.4-1.7
Fe content in liver0.40.51.2-1.10.4-1.0-0.10.30.9-0.4-0.90.40.40.9-0.40.5
K content in liver1.31.25.41.8-2.31.00.9-0.2-0.7-0.40.70.40.4-0.7-0.4-1.8
Mg content in liver2.02.05.91.0-2.1-0.3-0.61.30.6-1.7-0.61.71.70.6-1.7-2.4
Mn content in liver0.20.20.30.2-0.00.50.4-0.5-0.60.60.5-0.6-0.6-0.50.60.4
Na content in liver0.50.50.91.0-0.90.91.0-0.7-0.80.40.8-0.4-0.4-0.80.4-0.3
Rb content in liver0.20.20.80.8-0.70.30.20.1-0.2-0.30.20.30.3-0.2-0.3-0.9
Se content in liver0.30.31.31.0-1.10.50.00.1-0.5-0.10.40.10.1-0.4-0.1-0.8
Sr content in liver0.00.00.0-0.1-0.0-0.00.1-0.10.00.1-0.0-0.1-0.10.00.10.2
Zn content in liver0.91.03.51.9-1.41.20.7-0.4-1.10.11.1-0.1-0.1-1.10.1-1.3
Bone: minimum diameter0.71.23.40.8-1.7-0.4-0.20.90.5-1.3-0.71.31.30.7-1.3-1.8
Time in familiar zone, hab. session 10.40.40.70.30.40.60.3-0.6-0.60.80.7-0.8-0.8-0.70.80.7
Time in novel zone, hab. session 10.20.20.50.5-0.60.30.7-0.2-0.3-0.20.10.20.2-0.1-0.2-0.7
Total zone transitions, hab. session 10.30.41.6-0.81.30.00.4-0.5-0.10.60.1-0.6-0.6-0.10.61.0
Total locomotion distance, hab. session 10.40.62.5-1.51.6-0.8-0.30.10.70.0-0.6-0.0-0.00.60.01.1
Locomotion velocity, hab. session 10.30.41.9-1.31.4-0.6-0.2-0.00.50.1-0.5-0.1-0.10.50.11.0
Time in familiar zone, hab. session 20.70.72.71.6-1.61.00.4-0.2-0.80.00.8-0.0-0.0-0.80.0-1.1
Time in novel zone, hab. session 20.20.30.9-0.90.9-0.40.2-0.20.40.2-0.4-0.2-0.20.40.20.9
Total zone transitions, hab. session 20.10.10.50.4-0.60.10.10.10.0-0.40.10.40.4-0.1-0.4-0.7
Total locomotion distance, hab. session 20.20.30.4-0.4-0.1-0.6-0.50.60.6-0.7-0.60.70.70.6-0.7-0.4
Locomotion velocity, hab. session 20.30.40.6-0.60.0-0.7-0.60.70.8-0.7-0.70.70.70.7-0.7-0.4
Novel to familiar place preference ratio1.51.62.50.1-1.6-1.0-0.51.21.1-1.6-1.21.61.61.2-1.6-1.6
Novelty place preference0.80.91.50.1-1.2-0.7-0.20.80.8-1.2-0.91.21.20.9-1.2-1.1
Time in novel zone, NPP test0.60.71.40.2-1.2-0.6-0.00.70.6-1.0-0.71.01.00.7-1.0-1.1
Total zone transitions, NPP test0.60.81.5-1.20.7-1.2-1.00.91.1-0.7-1.10.70.71.1-0.70.2
Total locomotion distance, NPP test0.71.01.7-1.30.5-1.2-0.90.91.2-0.9-1.20.90.91.2-0.9-0.0
Locomotion velocity, NPP test1.21.72.5-1.60.5-1.5-1.41.31.6-1.2-1.51.21.21.5-1.2-0.1
Intraocular pressure0.20.40.5-0.0-0.7-0.4-0.50.70.5-0.7-0.50.70.70.5-0.7-0.7
Delta distance traveled before/after self-admin1.31.31.8-0.5-0.8-1.1-1.21.41.2-1.3-1.21.31.31.2-1.3-0.9
Delta ambulatory time before/after self-admin0.70.91.2-0.4-0.6-0.9-0.91.11.0-1.1-1.01.11.11.0-1.1-0.8
Parametrial fat weight0.00.00.2-0.1-0.10.10.1-0.2-0.10.30.1-0.2-0.2-0.10.20.4
Pavlov. Cond. lever latency1.51.93.71.9-0.51.61.1-1.2-1.71.31.6-1.3-1.3-1.61.3-0.0
Pavlov. Cond. magazine entry latency0.20.31.10.4-0.40.61.0-0.7-0.50.40.6-0.4-0.4-0.60.40.0
Pavlov. Cond. change in total contacts0.00.00.2-0.40.2-0.2-0.00.10.2-0.1-0.20.10.10.2-0.10.0
Pavlov. Cond. index score0.30.40.7-0.80.0-0.7-0.20.40.8-0.6-0.70.60.60.7-0.6-0.1
Pavlov. Cond. latency score0.40.50.9-1.00.1-0.7-0.20.50.9-0.8-0.80.80.80.8-0.8-0.1
Pavlov. Cond. lever contacts1.11.32.8-1.70.4-1.4-0.91.01.5-1.1-1.41.11.11.4-1.10.1
Pavlov. Cond. magazine entry number0.30.31.3-0.30.2-0.5-1.10.80.5-0.5-0.50.50.50.5-0.5-0.2
Pavlov. Cond. intertrial magazine entries1.01.22.20.3-1.3-0.6-0.91.20.8-1.3-0.71.31.30.7-1.3-1.5
Pavlov. Cond. lever-magazine prob. diff.0.40.50.8-0.9-0.1-0.8-0.30.60.9-0.8-0.80.80.80.8-0.8-0.2
Pavlov. Cond. response bias0.10.10.5-0.70.1-0.40.2-0.00.4-0.2-0.40.20.20.4-0.20.3
Pavlov. Cond. lever latency1.01.45.8-1.72.4-0.5-0.7-0.30.20.9-0.2-0.9-0.90.20.92.2
Pavlov. Cond. magazine entry latency1.82.26.92.6-2.41.61.8-0.7-1.3-0.11.30.10.1-1.3-0.1-2.1
Pavlov. Cond. change in total contacts0.91.56.32.0-2.50.70.50.3-0.5-0.80.50.80.8-0.5-0.8-2.3
Pavlov. Cond. index score1.72.38.62.6-2.91.31.5-0.3-1.0-0.61.00.60.6-1.0-0.6-2.6
Pavlov. Cond. latency score1.62.28.32.5-2.91.21.5-0.3-0.9-0.60.90.60.6-0.9-0.6-2.5
Pavlov. Cond. lever contacts0.81.14.41.5-2.10.50.80.1-0.3-0.80.30.80.8-0.3-0.8-1.9
Pavlov. Cond. magazine entry number2.42.98.7-2.92.2-2.1-2.21.21.8-0.4-1.80.40.41.8-0.41.9
Pavlov. Cond. intertrial magazine entries0.50.72.5-1.21.5-0.3-0.7-0.10.10.7-0.1-0.7-0.70.10.71.6
Pavlov. Cond. lever-magazine prob. diff.2.02.69.72.8-3.11.31.6-0.4-1.0-0.61.00.60.6-1.0-0.6-2.7
Pavlov. Cond. response bias1.11.65.32.2-2.31.11.3-0.3-0.9-0.40.90.40.4-0.9-0.4-2.1
Time in closed arm before self-admin0.30.40.60.00.50.50.1-0.5-0.70.80.7-0.7-0.7-0.70.70.8
Time in closed arm after self-admin0.20.20.5-0.20.60.3-0.3-0.2-0.40.60.4-0.5-0.5-0.40.50.7
Time in open arm before self-admin0.20.21.10.8-1.00.20.30.0-0.0-0.2-0.00.20.20.0-0.2-1.0
Time in open arm after self-admin0.70.81.2-0.1-0.7-0.80.20.60.9-1.1-1.01.01.00.9-1.0-1.1
Bone: periosteal estimation0.20.40.7-0.3-0.1-0.8-0.30.60.7-0.7-0.90.70.70.9-0.7-0.5
Bone: periosteal perimeter0.10.20.50.4-0.5-0.10.20.20.2-0.4-0.30.40.40.3-0.4-0.7
Bone: post-yield work0.10.10.80.4-0.30.30.9-0.4-0.30.10.2-0.1-0.1-0.20.1-0.2
Progressive ratio test 1 active lever presses0.60.71.2-1.00.4-1.1-1.11.01.0-0.9-0.90.70.71.0-0.9-0.0
Progressive ratio test 1 breakpoint0.60.81.2-1.00.5-1.1-1.11.01.1-0.9-0.90.70.71.0-0.90.0
Progressive ratio test 1 inactive lever presses0.30.50.8-0.90.5-0.9-0.80.80.8-0.6-0.70.40.40.7-0.60.1
Progressive ratio test 2 active lever presses0.50.61.0-0.90.4-0.8-0.80.81.0-0.8-0.90.70.70.8-0.80.0
Progressive ratio test 2 breakpoint0.60.61.3-1.10.7-0.9-0.80.81.0-0.8-0.90.70.70.8-0.70.3
Progressive ratio test 2 inactive lever presses0.10.10.2-0.3-0.1-0.2-0.20.40.5-0.5-0.40.20.20.3-0.4-0.2
Incentive Sensitization - Responses0.00.00.0-0.20.10.00.00.10.2-0.1-0.20.10.10.1-0.10.0
Incentive Sensitization - Breakpoint0.00.00.1-0.20.1-0.1-0.10.20.3-0.2-0.30.20.20.1-0.20.0
Sum of active levers in priming session hrs 5-60.30.31.6-1.01.3-0.70.10.00.4-0.1-0.40.20.20.5-0.20.7
Progressive ratio0.10.20.4-0.1-0.1-0.5-0.40.50.5-0.6-0.50.40.40.6-0.4-0.5
Food seeking constrained by brief footshock2.53.04.11.10.41.91.5-1.9-2.02.02.0-1.9-1.9-1.92.01.1
Seeking ratio, punishment vs. effort2.33.34.51.10.32.01.9-2.1-2.02.12.0-1.9-1.9-2.11.91.3
Retroperitoneal fat weight0.10.30.50.30.20.50.5-0.6-0.60.70.5-0.6-0.6-0.50.60.4
Reaction time number correct0.20.42.0-0.81.4-0.2-0.1-0.3-0.00.50.0-0.6-0.6-0.00.61.2
Reaction time mean minus median0.61.45.72.1-2.40.90.60.0-0.7-0.50.60.40.4-0.6-0.5-2.2
Reaction time mean minus median AUC0.40.93.51.8-1.90.80.6-0.1-0.7-0.20.60.20.2-0.6-0.3-1.7
Reaction time num false alarms1.31.83.30.2-1.8-0.8-1.01.41.1-1.7-0.91.61.61.0-1.6-1.8
Reaction time num false alarms AUC2.03.14.80.0-2.0-1.2-1.41.91.5-2.2-1.42.12.11.4-2.1-2.2
Reaction time trials correct on left0.20.42.0-0.81.4-0.2-0.1-0.3-0.00.50.0-0.6-0.6-0.00.61.2
Reaction time trials on left0.20.31.7-0.71.3-0.2-0.1-0.2-0.00.50.0-0.5-0.5-0.00.51.0
Reaction time mean0.60.93.51.9-1.71.00.7-0.2-0.8-0.10.70.10.1-0.7-0.2-1.6
Reaction time mean AUC0.50.83.11.7-1.31.10.9-0.5-0.90.20.8-0.1-0.1-0.90.1-1.2
Median of all reaction times0.40.62.21.5-1.10.90.8-0.4-0.80.10.7-0.1-0.1-0.70.1-1.0
Reaction time omissions0.91.45.41.7-2.00.3-0.00.70.0-1.0-0.21.11.10.0-1.1-2.3
Reaction time false alarm rate2.63.66.50.3-2.5-1.1-1.42.01.5-2.3-1.42.32.31.4-2.2-2.5
Reaction time premature initiation rate0.30.41.81.1-1.40.60.5-0.2-0.60.10.4-0.1-0.1-0.30.0-0.8
Reaction time premature initiations0.10.20.50.7-0.40.50.5-0.5-0.70.50.5-0.5-0.5-0.40.4-0.1
Std. dev. reaction times0.81.56.02.1-2.50.80.40.2-0.5-0.70.40.60.6-0.4-0.7-2.4
Reaction time trials completed0.20.31.7-0.71.3-0.2-0.1-0.2-0.00.50.0-0.5-0.5-0.00.51.0
Reaction time trials AUC0.10.31.6-0.71.3-0.4-0.2-0.00.20.3-0.2-0.3-0.30.20.30.9
Run reversals in cocaine runway, females0.30.30.80.9-0.90.60.8-0.4-0.30.10.30.00.0-0.40.0-0.6
Run reversals in cocaine runway, males2.22.25.2-0.1-2.3-1.1-0.51.31.4-1.7-1.41.71.71.4-1.7-1.8
Latency to leave start box in cocaine runway0.91.12.3-1.51.3-1.3-0.60.81.2-0.9-1.20.90.91.1-0.90.4
Latency to leave start box in cocaine runway, F1.51.84.2-2.11.3-1.7-1.01.11.6-1.1-1.61.01.01.4-1.00.6
Latency to leave start box in cocaine runway, M0.20.10.70.9-0.40.50.2-0.2-0.30.10.30.00.0-0.2-0.0-0.7
Std. dev. time between licks in bursts1.82.43.91.7-0.22.01.4-1.5-1.91.51.9-1.5-1.5-1.91.50.2
Total sessions with >9 infusions0.10.10.40.5-0.60.20.2-0.0-0.1-0.10.1-0.1-0.1-0.1-0.0-0.5
Short access day 1 total inactive lever presses1.51.92.7-1.40.3-1.6-1.61.61.6-1.5-1.61.41.41.5-1.4-0.3
Short access day 10 total inactive lever presses0.10.20.3-0.2-0.2-0.5-0.50.50.5-0.5-0.50.60.60.5-0.5-0.3
Short access day 1 total infusions0.00.00.0-0.20.2-0.1-0.10.10.1-0.0-0.1-0.1-0.10.10.00.1
Short access day 10 total infusions0.30.41.5-1.11.2-0.7-0.60.30.5-0.1-0.4-0.0-0.00.4-0.10.9
Short access total infusions0.00.10.10.2-0.00.20.2-0.2-0.20.20.2-0.4-0.4-0.20.30.1
Short access day 1 locomotion1.01.21.9-0.2-1.0-0.9-1.01.21.1-1.4-1.11.21.21.1-1.2-1.2
Short access day 10 total locomotion0.40.70.9-0.70.1-0.9-1.00.90.9-0.9-0.90.90.90.9-0.8-0.2
Short access total locomotion0.00.00.10.00.20.20.2-0.2-0.10.20.2-0.2-0.2-0.20.30.2
One hour access (0.3 mA shock)0.10.10.20.4-0.30.40.4-0.2-0.20.10.2-0.1-0.1-0.30.0-0.1
Compulsive drug intake0.81.01.50.20.80.80.9-1.1-1.01.21.0-1.2-1.2-0.91.11.0
One hour access (shock baseline)1.01.52.1-0.6-0.6-1.1-1.21.41.4-1.5-1.31.41.41.2-1.4-0.9
Social response proportion0.20.20.80.9-0.70.60.5-0.4-0.60.30.5-0.3-0.3-0.40.3-0.4
Social responses1.11.42.21.5-0.61.51.4-1.3-1.41.11.5-1.0-1.0-1.21.0-0.1
Social time0.10.10.40.5-0.7-0.1-0.20.30.2-0.4-0.10.40.40.2-0.4-0.6
Soleus weight2.57.59.7-2.30.4-3.1-3.13.13.1-2.9-3.12.92.93.1-2.9-1.1
Bone: stiffness0.00.00.10.3-0.10.2-0.10.1-0.2-0.00.10.00.0-0.1-0.0-0.3
Tibialis anterior weight3.210.918.4-4.32.4-4.1-3.93.34.0-2.6-3.92.62.63.9-2.60.7
Time to tail flick, vehicle, before self-admin2.02.13.3-1.80.5-1.8-1.21.41.6-1.5-1.61.61.61.5-1.60.2
Time to tail flick, vehicle, after self-admin0.50.61.8-1.31.3-1.1-0.70.60.8-0.4-0.80.40.40.9-0.40.6
Time to tail flick, test, before self-admin3.23.39.5-3.12.8-2.4-1.51.31.7-1.0-1.81.11.11.8-1.11.6
Time to tail flick, test, after self-admin1.21.23.2-1.51.3-1.4-1.81.31.1-0.7-1.10.60.61.1-0.60.5
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.30.7-0.20.1-0.10.00.2-0.0-0.3-0.30.10.30.3
Delta time to tail flick, test, before/after SA0.50.52.01.3-1.40.70.1-0.1-0.40.00.4-0.2-0.2-0.40.2-1.1
Tibia length0.10.30.7-0.4-0.9-0.6-0.60.70.5-0.5-0.60.50.50.6-0.5-0.3
Ambulatory time before self-admin0.10.10.8-0.40.9-0.30.00.00.20.0-0.2-0.2-0.20.30.10.3
Ambulatory time after self-admin0.40.51.0-0.80.9-1.0-0.50.60.8-0.6-0.80.50.50.9-0.50.0
Bone: tissue strength0.80.91.91.4-1.11.11.2-0.8-1.10.51.0-0.5-0.5-1.00.5-0.5
Total heroin consumption0.40.40.70.50.50.60.8-0.8-0.70.80.7-0.7-0.7-0.50.70.2
Bone: trabecular number0.61.01.40.80.11.21.1-1.1-1.21.01.2-1.0-1.0-1.21.00.4
Bone: trabecular spacing1.11.42.7-1.30.7-1.4-1.61.31.4-1.0-1.41.01.01.4-1.00.0
Bone: trabecular thickness0.50.71.31.1-1.01.01.2-0.8-0.90.50.9-0.5-0.5-0.90.5-0.3
Bone: trabecular tissue density0.30.41.3-0.30.70.20.2-0.6-0.40.80.4-0.8-0.8-0.40.81.2
Water consumed over 24 hours1.11.53.20.0-1.1-0.7-0.81.30.9-1.6-0.91.61.60.9-1.6-1.8
Number of responses in last shaping day2.42.63.7-0.9-0.6-1.6-1.71.91.8-1.9-1.71.91.91.7-1.9-1.1