Hub : Genes

Zfp950l6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Zfp950l6	0.2	0.08	8.9e-10	0.1	0.11	0.1	0.1	1.2e-09	4.2e-10	9.0e-10	5.4e-10
2	LHb	gene expression	Zfp950l6	0.16	0.11	9.8e-03	0	0.01	-0.01	-0.01	2.4e-01	1.8e-01	6.4e-01	6.6e-01
3	IC	gene expression	Zfp950l6	0.13	0.08	1.1e-03	0.03	0.09	0.02	0.07	2.5e-02	1.7e-04	5.1e-02	4.7e-04
4	pVTA	gene expression	Zfp950l6	0.07	0.04	9.9e-06	0.06	0.07	0.06	0.05	2.2e-05	4.2e-06	1.9e-05	4.5e-05
5	Adipose	gene expression	Zfp950l6	0.08	0.05	6.7e-05	0	0.03	0.04	0	2.6e-01	8.1e-04	6.2e-05	7.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.4	0.8	0.6	0.9	0.7	0.6	-0.4
Area under the delay curve	1.5	2.4	3.1	-1.4	-1.8	-1.3	-1.5	1.7
BMI with tail	1.3	4.4	12.5	3.5	2.0	1.7	1.7	-0.1
BMI without tail	1.4	7.6	10.5	3.0	2.6	3.2	3.2	-1.3
Body weight	3.0	13.3	28.0	5.3	3.5	3.5	3.6	-0.9
Weight adjusted by age	1.5	4.4	7.6	2.8	2.7	1.9	1.9	-0.6
Bone surface	0.5	1.0	1.5	1.2	1.0	1.2	1.2	-0.1
Bone volume	0.4	0.9	1.1	1.0	1.0	1.1	1.0	-0.5
Breakpoint value in progressive ratio session	0.4	0.7	1.9	1.4	-0.5	0.2	0.2	1.2
Number of licking bursts	0.1	0.3	1.1	-0.3	0.2	0.4	0.4	-1.0
Context. condit. distance diff. score	0.9	1.1	2.3	0.4	0.4	1.5	1.5	-0.9
Locomotion velocity, session 1	2.2	2.5	5.3	-1.1	-0.8	-2.3	-2.1	0.6
Locomotion distance, session 1	0.5	0.6	1.9	0.1	-0.8	-0.4	-0.6	1.4
Locomotion velocity, session 2	3.5	4.2	5.4	-1.6	-2.3	-1.9	-2.1	2.3
Locomotion distance, session 2	0.3	0.4	1.7	0.3	-0.3	0.4	0.2	1.3
Locomotion velocity, session 3	3.4	3.9	5.6	-1.4	-1.7	-2.0	-2.2	2.4
Locomotion distance, session 3	4.2	4.8	7.0	-1.5	-2.3	-2.0	-2.3	2.6
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	0.4	0.1	-0.6	-0.6	0.5
Stereotopy head waving duration, day 3	0.2	0.2	0.6	0.8	0.2	0.0	-0.0	0.6
Locomotion velocity, session 7	0.5	0.6	1.2	-0.8	-1.1	-0.5	-0.6	0.7
Locomotion distance, session 7	2.6	3.3	6.1	-2.1	-2.5	-1.2	-1.4	1.5
Stereotopy head waving bouts, day 7	1.8	2.1	4.2	2.1	1.3	1.5	1.5	-0.6
Stereotopy head waving duration, day 7	1.2	1.5	2.8	1.7	1.3	1.2	1.2	-0.5
Locomotion velocity, session 8	0.3	0.4	1.9	0.1	-0.2	-0.1	-0.4	1.4
Locomotion distance, session 8	1.4	2.0	4.9	1.1	0.3	2.2	1.9	0.5
Degree of sensitization distance	0.7	0.8	2.0	-0.4	0.4	0.8	0.9	-1.4
Degree of sensitization stereotypy	1.4	1.6	2.8	1.7	1.1	1.4	1.4	-0.5
Conditioned locomotion	3.5	4.1	5.6	1.6	2.2	2.3	2.4	-1.5
Cocaine response after cond. corrected	0.5	0.8	1.5	-0.8	-0.6	-1.2	-1.2	0.5
Cocaine response after cond. not corrected	0.9	1.3	1.7	-1.0	-1.2	-1.3	-1.3	1.0
Cocaine response before conditioning	0.5	0.6	1.4	-0.4	-1.2	0.2	0.0	1.1
Saline control response	0.5	0.6	1.1	-0.8	1.0	0.4	0.4	-1.0
Bone: connectivity density	0.1	0.1	0.3	-0.2	0.3	0.5	0.3	0.1
Bone: cortical apparent density	3.6	5.7	7.3	-2.7	-2.3	-2.6	-2.7	1.4
Bone: cortical area	8.9	14.4	34.6	5.9	4.3	3.2	2.9	0.4
Bone: cortical porosity	1.0	1.1	3.6	1.9	1.0	0.4	0.7	-0.4
Bone: cortical porosity	1.2	1.3	3.3	1.8	1.3	0.6	0.8	-0.6
Bone: cortical thickness	5.7	9.5	24.4	4.9	4.2	1.7	1.6	0.1
Bone: cortical thickness	1.5	1.8	4.7	2.2	2.0	0.4	0.4	-0.4
Bone: cortical tissue density	4.1	6.5	9.1	-3.0	-2.5	-2.8	-2.8	1.3
Condit. Reinf. active minus inactive responses	1.9	2.1	3.7	1.5	1.9	1.4	1.4	-0.9
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.2	1.2	1.5	0.7	0.5	0.3
Condit. Reinf. active responses	3.2	4.1	5.2	1.7	2.3	2.0	2.2	-1.8
Condit. Reinf. inactive responses	1.0	1.2	2.8	0.3	0.7	1.0	1.3	-1.7
Incentive salience index mean	1.5	2.0	2.5	1.4	1.6	1.5	1.5	-0.8
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.1	-0.3	0.6	0.6	-0.5
Condit. Reinf. active minus inactive responses	1.5	2.2	5.0	2.2	1.9	1.2	1.0	-0.0
Condit. Reinf. active-inactive response ratio	2.5	3.9	7.1	2.6	2.7	1.4	1.4	-1.4
Condit. Reinf. active responses	0.6	0.9	2.0	1.4	0.9	0.8	0.5	0.9
Condit. Reinf. inactive responses	1.0	1.5	4.5	-0.7	-1.2	-0.5	-0.9	2.1
Condit. Reinf. lever presses	0.2	0.3	0.6	0.2	0.2	0.7	0.6	0.5
Condit. Reinf. lever reinforcers received	0.8	1.2	2.4	1.6	0.8	1.2	0.9	0.8
Conditioned reinforcement - actives	0.1	0.5	1.3	-0.9	-1.1	-0.1	-0.1	0.6
Conditioned reinforcement - inactives	0.0	0.1	0.4	-0.4	-0.6	-0.0	0.0	0.1
Conditioned locomotion	0.9	1.4	5.1	-0.2	-1.0	0.8	0.5	2.3
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.8	-0.2	-0.4	-0.5	0.3
Patch foraging indifference point AUC	0.1	0.3	1.2	-0.5	0.0	0.1	0.3	-1.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	0.3	0.3	-0.1	-0.3	0.7
Delay disc. indifference point, 16s delay	1.2	1.7	3.7	-1.2	-1.9	-0.3	-0.6	1.7
Delay disc. indifference point, 2s delay	0.3	0.4	0.9	-0.1	-0.8	-0.4	-0.5	0.9
Delay disc. indifference point, 24s delay	3.0	4.8	5.9	-1.5	-2.4	-2.3	-2.4	2.2
Delay disc. indifference point, 4s delay	1.6	1.7	2.6	-1.5	-0.7	-1.4	-1.6	1.1
Delay disc. indifference point, 8s delay	1.0	1.7	3.2	-1.1	-1.0	-1.7	-1.8	0.6
Indifference point function ln k	0.3	0.9	2.6	-0.2	-0.5	-0.7	-1.1	1.6
Indifference point function log k	0.3	0.9	2.6	-0.2	-0.5	-0.7	-1.1	1.6
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.7	-0.2	-0.3	-0.5	0.3
Patch foraging total patch changes 12 sec	0.2	0.3	0.8	-0.8	-0.3	-0.4	-0.1	-0.9
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.5	-0.4	0.1	-0.1	0.3
Patch foraging total patch changes 24 sec	0.0	0.1	0.3	0.1	0.5	0.1	0.1	-0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	-0.3	0.5	0.0	0.2	-0.8
Patch foraging time to switch 0 sec	0.0	0.1	0.4	-0.1	-0.6	-0.1	-0.1	0.6
Patch foraging water rate 0 sec	0.0	0.1	0.2	-0.5	0.3	0.2	0.1	-0.5
Patch foraging water rate 12 sec	0.0	0.1	0.2	0.1	0.2	-0.0	-0.2	0.4
Patch foraging water rate 18 sec	0.3	0.6	1.0	0.9	0.7	1.0	0.8	-0.2
Patch foraging water rate 24 sec	0.9	1.3	2.2	1.3	0.9	1.5	1.1	0.8
Patch foraging water rate 6 sec	0.3	0.4	1.1	0.1	-0.5	-0.4	-0.6	1.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.5	1.4	0.2	1.2	0.5	0.5	-0.7
Distance traveled before self-admin	0.1	0.1	0.4	0.1	0.3	0.0	-0.1	0.6
Distance traveled after self-admin	0.3	0.5	0.8	-0.8	-0.7	0.8	0.9	-0.3
Extensor digitorum longus weight	0.8	3.1	4.1	2.0	1.3	2.0	2.0	-1.3
Bone: elastic displacement	0.4	0.5	1.7	0.7	1.3	0.4	0.5	0.1
Bone: elastic work	4.8	6.3	15.7	3.3	4.0	1.3	1.5	-1.0
Bone: endosteal estimation	1.2	2.9	5.2	2.1	0.2	2.3	2.1	0.5
Bone: endosteal perimeter	1.2	2.9	5.1	2.3	1.6	1.9	1.8	0.0
Epididymis fat weight	0.7	3.7	5.5	2.1	1.3	2.2	2.3	-1.5
Delta time in closed arm before/after self-admin	0.3	0.3	1.2	-0.5	-0.1	0.0	0.0	-1.1
Delta time in open arm before/after self-admin	1.0	1.2	1.8	-1.3	-1.2	-0.9	-1.0	0.9
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.3	-0.2	0.2	0.3	-0.1
Delay discount exponential model param	2.8	3.8	4.4	1.8	2.1	1.8	2.0	-2.0
Extinction: sum of active levers before priming	0.4	0.7	1.6	0.2	-0.3	-1.3	-1.2	0.2
Active lever presses in extinction session 6	1.9	1.9	3.2	0.8	-1.1	-1.5	-1.5	1.8
Bone: final force	8.5	13.9	30.6	5.5	4.1	3.4	3.2	-0.1
Bone: final moment	9.6	15.4	33.5	5.8	4.5	3.5	3.3	-0.4
Food consumed during 24 hour testing period	0.2	0.3	0.9	-0.2	0.6	0.3	0.4	-1.0
Glucose	5.0	7.9	15.1	-1.1	-2.1	-3.9	-3.8	2.3
Heart weight	1.6	2.5	5.9	2.4	1.7	1.2	1.4	-0.5
Delay discount hyperbolic model param	2.6	3.3	3.9	1.7	2.0	1.7	1.9	-1.7
Intermittent access intake day 1-15 change	0.3	1.4	3.4	-1.8	-1.4	-0.8	-0.8	0.6
Intermittent access intake escalation	0.3	1.8	4.2	-2.1	-1.3	-1.0	-1.1	0.8
Intermittent access intake escalation 2	0.5	0.8	1.4	-1.2	-0.8	-0.6	-0.6	1.1
Intermitt. access day 1 inactive lever presses	0.1	0.8	1.8	-0.0	0.2	1.3	1.3	-0.7
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.3	-0.2	0.1	1.1	0.9	0.7
Intermitt. access escalation Index	0.2	0.5	1.5	-1.2	0.1	-0.2	-0.2	-1.0
Intermittent access day 1 total infusions	0.2	0.6	1.0	0.8	0.5	0.8	1.0	-0.5
Intermittent access day 15 total infusions	0.0	0.1	0.5	-0.7	-0.3	0.0	0.1	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	-0.6	-0.2	0.1	0.3	-0.4
Intermittent access total infusions	0.1	0.1	0.2	-0.4	-0.1	0.1	0.3	-0.4
Intermittent access day 1 locomotion	0.3	0.5	1.4	-0.5	-0.9	-0.3	-0.3	1.2
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.1	-0.1	0.2	0.2	0.3
Intermittent access total locomotion	0.2	0.3	0.5	-0.5	-0.7	-0.2	-0.2	0.7
Intermittent access standard deviation	0.5	2.7	3.6	-1.2	-1.7	-1.6	-1.7	1.9
Left kidney weight	0.4	3.3	11.4	3.4	1.3	1.2	1.2	0.9
Right kidney weight	0.3	2.3	8.3	2.9	1.1	0.6	0.6	1.2
Cocaine induced anxiety	0.3	0.9	2.1	0.4	0.4	-1.4	-1.3	0.5
Post-drug Anxiety	2.0	2.3	4.2	-0.4	-0.6	-2.1	-2.0	1.6
Baseline Anxiety	0.5	0.8	1.4	-1.0	-1.2	-0.6	-0.7	1.0
Tail length	1.3	7.0	11.4	1.8	2.5	3.1	3.4	-2.2
Length with tail	0.7	3.1	6.4	2.5	1.9	1.6	1.7	-0.5
Length without tail	0.3	1.5	5.7	2.4	1.1	-0.4	-0.3	0.6
Times rat made contact with spout	1.3	1.5	6.0	-0.8	0.9	0.1	0.5	-2.4
Lifetime Intake	0.3	0.3	1.0	-1.0	-0.7	-0.5	-0.3	-0.2
Liver weight, left	0.4	0.7	1.9	-0.1	-1.4	-0.6	-0.6	1.0
Liver weight, right	2.6	4.6	6.5	2.5	1.6	2.6	2.5	-1.1
Locomotor activity	0.4	0.6	1.7	-0.3	-1.3	-0.3	-0.4	1.0
Locomotor testing distance	0.3	0.7	1.9	-0.1	-1.2	-0.2	-0.5	1.4
Locomotor testing rearing	0.4	1.6	3.4	-1.8	-1.8	-0.6	-0.8	0.5
Locomotion in novel chamber	0.2	0.3	0.9	0.9	0.6	0.5	0.3	0.0
Locomotion in novel chamber post-restriction	1.3	3.9	5.8	1.4	1.9	1.9	2.1	-2.4
Fecal boli incidents, locomotor time 1	0.1	0.4	0.8	0.5	-0.4	0.8	0.9	0.2
Change in fecal boli incidents, locomotor task	3.5	3.7	6.1	-2.1	-1.7	-2.5	-2.2	0.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.5	-0.5	0.2	0.7	0.4	0.3
Bouts of movement, locomotor time 1	0.2	0.3	0.6	-0.3	-0.4	-0.8	-0.7	0.4
Total resting periods, locomotor time 1	0.5	0.6	1.0	-0.6	-0.7	-1.0	-1.0	0.5
Rest time, locomotor task time 1	0.1	0.2	0.6	-0.1	-0.5	-0.2	0.0	0.8
Distance moved, locomotor task time 1	0.2	0.6	1.0	-1.0	-0.8	-0.8	-0.9	-0.4
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.2	0.2	0.5	0.4	0.1
Time >=10cm from walls, locomotor time 2	0.2	0.7	2.0	0.9	1.4	0.4	0.4	-0.6
Bouts of movement, locomotor time 2	0.1	0.4	0.7	-0.3	-0.8	-0.7	-0.7	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.3	0.1	-0.5	-0.0	-0.0	-0.3
Rest time, locomotor task time 2	0.2	0.4	0.9	0.4	0.0	0.9	1.0	-0.2
Distance moved, locomotor task time 2	0.4	0.5	1.0	-0.7	-0.3	-1.0	-1.0	-0.2
Vertical activity count, locomotor time 2	0.2	0.5	1.1	0.9	0.1	0.6	0.4	1.1
Light reinforcement 1	0.5	2.2	4.7	0.4	1.6	1.2	1.4	-2.2
Light reinforcement 2	1.1	2.6	3.1	1.5	1.8	1.5	1.7	-1.5
Bone: marrow area	1.1	2.8	5.0	2.1	0.2	2.2	2.1	0.6
Bone: maximum diameter	3.1	6.1	15.2	3.9	2.4	2.3	2.0	0.6
Bone: maximum force	8.7	17.2	37.6	6.1	4.4	3.9	3.7	-0.2
Bone: maximum moment	9.8	18.6	40.3	6.4	4.8	3.9	3.8	-0.5
Mean time between licks in bursts	0.4	2.5	3.3	-1.6	-1.8	-1.6	-1.7	1.1
Mean num. licks in bursts	0.0	0.1	0.3	-0.0	0.5	-0.1	0.1	-0.6
Cd content in liver	0.3	0.3	1.0	-0.4	-1.0	0.5	0.5	0.2
Co content in liver	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.0	0.1
Cu content in liver	0.2	0.2	0.5	-0.5	0.5	-0.4	-0.3	-0.7
Fe content in liver	0.3	0.4	1.2	-0.1	-1.1	0.3	0.2	0.7
K content in liver	0.4	0.4	1.6	-1.3	-0.3	0.5	0.4	-0.2
Mg content in liver	1.0	1.1	4.0	-2.0	-1.1	0.3	0.3	0.1
Mn content in liver	0.3	0.3	0.9	-0.9	-0.3	-0.5	-0.5	0.4
Na content in liver	0.8	0.9	1.6	-1.3	-1.0	-0.4	-0.6	1.1
Rb content in liver	1.2	1.4	2.5	0.6	1.2	1.6	1.4	-0.6
Se content in liver	0.5	0.6	1.9	-1.4	-0.3	-0.3	-0.1	-0.9
Sr content in liver	0.9	0.8	1.8	-0.8	-0.0	-1.4	-1.2	0.2
Zn content in liver	1.2	1.4	2.6	0.7	0.8	1.5	1.6	-1.0
Bone: minimum diameter	3.4	6.6	12.4	3.5	3.2	2.3	2.2	-0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.0	0.0	-0.5	-0.4	-0.3
Time in novel zone, hab. session 1	0.1	0.1	0.4	-0.6	-0.1	-0.2	-0.2	-0.0
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.1	-0.5	-0.2	-0.2	0.6
Total locomotion distance, hab. session 1	0.5	0.7	1.3	0.9	0.6	1.1	1.1	-0.1
Locomotion velocity, hab. session 1	0.8	1.1	1.9	1.2	0.5	1.4	1.4	-0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.6	-0.7	-0.5	-0.4	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.3	0.2	-0.1	-0.2	0.6
Total zone transitions, hab. session 2	0.5	0.6	1.3	0.7	0.5	1.1	1.1	-0.2
Total locomotion distance, hab. session 2	1.7	2.2	3.7	1.2	1.2	1.9	1.9	-1.0
Locomotion velocity, hab. session 2	2.0	2.7	4.3	1.4	1.4	2.1	2.1	-1.0
Novel to familiar place preference ratio	1.1	1.5	4.0	1.4	2.0	0.4	0.6	-1.0
Novelty place preference	1.3	1.6	4.4	1.5	2.1	0.4	0.6	-1.0
Time in novel zone, NPP test	1.1	1.3	3.6	1.3	1.9	0.4	0.5	-0.9
Total zone transitions, NPP test	0.4	0.6	1.4	0.1	-0.4	1.2	0.9	0.7
Total locomotion distance, NPP test	1.0	1.4	3.6	0.6	0.1	1.9	1.8	0.0
Locomotion velocity, NPP test	1.1	1.5	3.5	0.9	0.4	1.9	1.8	-0.2
Intraocular pressure	1.3	2.2	4.3	1.5	0.8	2.1	1.9	0.0
Delta distance traveled before/after self-admin	0.7	0.7	2.0	-1.4	-1.3	-0.3	-0.2	-0.2
Delta ambulatory time before/after self-admin	0.7	1.1	3.0	-1.7	-1.4	-0.4	-0.3	-0.6
Parametrial fat weight	0.8	1.8	3.6	0.5	0.9	1.3	1.7	-1.9
Pavlov. Cond. lever latency	0.6	0.8	2.4	-0.0	-1.0	0.6	0.3	1.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.6	0.4	1.3	-0.3	-0.1	-1.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	-0.2	0.1	-0.8	-0.6	-0.5
Pavlov. Cond. index score	1.1	1.4	3.0	0.8	1.7	0.3	0.6	-1.7
Pavlov. Cond. latency score	1.0	1.2	3.1	0.6	1.6	0.1	0.4	-1.8
Pavlov. Cond. lever contacts	0.3	0.4	1.5	0.2	0.7	-0.0	0.2	-1.2
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	-0.6	-1.3	0.4	0.1	1.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.7	0.6	0.6	1.2	1.3	-1.2
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.7	0.7	1.6	0.2	0.4	-1.5
Pavlov. Cond. response bias	0.5	0.6	1.5	0.4	1.1	-0.4	-0.1	-1.2
Pavlov. Cond. lever latency	1.4	2.0	3.8	-1.3	-1.1	-1.9	-1.9	-0.3
Pavlov. Cond. magazine entry latency	1.0	1.5	3.6	-0.9	-1.9	0.0	-0.0	1.7
Pavlov. Cond. change in total contacts	0.3	0.8	2.4	0.6	-0.3	0.8	0.6	1.5
Pavlov. Cond. index score	0.4	0.7	1.5	0.3	-0.5	0.9	0.9	1.2
Pavlov. Cond. latency score	0.4	0.7	1.3	0.3	-0.5	1.0	0.9	1.1
Pavlov. Cond. lever contacts	1.2	1.7	3.4	1.1	0.9	1.8	1.7	0.5
Pavlov. Cond. magazine entry number	1.1	1.4	3.4	1.1	1.8	0.2	0.2	-1.6
Pavlov. Cond. intertrial magazine entries	0.7	1.6	2.5	1.1	1.6	1.3	1.2	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.7	1.8	0.0	-0.8	0.7	0.6	1.4
Pavlov. Cond. response bias	0.4	0.6	1.0	0.5	-0.2	1.0	0.9	1.0
Time in closed arm before self-admin	0.2	0.3	0.5	0.2	-0.1	-0.7	-0.7	0.7
Time in closed arm after self-admin	1.2	1.4	2.2	-1.3	-1.0	-1.5	-1.4	-0.1
Time in open arm before self-admin	2.1	2.6	4.2	1.3	1.7	1.4	1.4	-2.0
Time in open arm after self-admin	0.2	0.2	0.3	0.5	0.0	0.5	0.3	0.5
Bone: periosteal estimation	4.5	10.7	24.6	5.0	2.9	3.3	3.1	0.5
Bone: periosteal perimeter	4.0	7.9	19.3	4.4	3.5	2.0	2.0	0.0
Bone: post-yield work	0.4	0.6	1.7	1.3	0.4	0.7	0.5	0.8
Progressive ratio test 1 active lever presses	0.2	0.4	0.9	-0.9	-0.9	-0.4	-0.3	0.1
Progressive ratio test 1 breakpoint	0.2	0.3	0.8	-0.9	-0.8	-0.3	-0.3	-0.0
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.7	-0.0	0.4	1.2	1.3	-0.8
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.1	-0.3	0.4	0.5	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.1	-0.4	0.4	0.4	0.2
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.0	0.5
Incentive Sensitization - Responses	0.2	0.5	1.1	0.3	0.3	0.9	1.1	-0.4
Incentive Sensitization - Breakpoint	0.2	0.4	0.9	0.3	0.3	0.8	1.0	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.3	0.2	-0.2	-0.5	-0.2	-0.6
Progressive ratio	0.4	1.1	2.7	1.3	-0.5	0.7	0.4	1.7
Food seeking constrained by brief footshock	0.6	0.8	1.3	-1.1	-0.6	-1.1	-1.0	-0.3
Seeking ratio, punishment vs. effort	0.3	0.6	1.3	-1.1	0.3	-0.6	-0.5	-0.9
Retroperitoneal fat weight	2.3	10.3	17.2	3.0	2.5	4.1	4.1	-1.7
Reaction time number correct	0.2	0.6	2.0	0.0	-0.1	1.4	1.1	-0.2
Reaction time mean minus median	0.1	0.4	0.9	-0.6	-0.9	-0.6	-0.4	-0.4
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.1	-0.3	-0.0	-0.0	-0.5
Reaction time num false alarms	0.1	0.2	0.7	0.8	0.4	0.3	0.3	-0.4
Reaction time num false alarms AUC	0.0	0.1	0.2	0.5	-0.0	0.2	0.2	-0.3
Reaction time trials correct on left	0.2	0.6	2.0	0.0	-0.1	1.4	1.1	-0.2
Reaction time trials on left	0.2	0.6	2.0	0.0	-0.1	1.4	1.1	-0.2
Reaction time mean	0.2	0.5	0.8	0.7	0.5	0.8	0.9	-0.3
Reaction time mean AUC	0.3	0.7	1.4	0.8	0.5	1.2	1.2	-0.1
Median of all reaction times	0.5	0.7	1.1	0.9	0.8	1.0	1.0	0.0
Reaction time omissions	0.0	0.1	0.1	-0.3	-0.3	0.2	0.1	-0.3
Reaction time false alarm rate	0.1	0.1	0.4	0.3	0.0	-0.6	-0.4	-0.2
Reaction time premature initiation rate	0.6	0.9	1.3	-1.1	-1.1	-1.1	-1.0	-0.0
Reaction time premature initiations	0.1	0.4	1.1	-0.8	-1.0	0.0	-0.1	-0.2
Std. dev. reaction times	0.0	0.1	0.6	-0.3	-0.8	-0.1	-0.0	0.1
Reaction time trials completed	0.2	0.6	2.0	0.0	-0.1	1.4	1.1	-0.2
Reaction time trials AUC	0.2	0.6	2.0	0.1	-0.0	1.4	1.1	-0.3
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.0	-0.2	0.2	0.2	0.3
Run reversals in cocaine runway, males	0.4	0.4	0.8	0.4	0.9	0.3	0.6	-0.8
Latency to leave start box in cocaine runway	0.3	0.4	0.8	0.4	-0.6	0.8	0.9	0.5
Latency to leave start box in cocaine runway, F	1.1	1.3	2.8	0.8	-0.3	1.7	1.6	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	-0.4	-0.4	-0.3	-0.4
Std. dev. time between licks in bursts	0.3	0.6	1.5	-0.0	-0.2	1.2	0.9	0.6
Total sessions with >9 infusions	0.3	0.4	0.8	-0.6	-0.9	-0.6	-0.6	0.5
Short access day 1 total inactive lever presses	0.1	0.3	0.5	0.7	-0.3	0.6	0.6	-0.2
Short access day 10 total inactive lever presses	0.2	1.3	2.2	0.7	1.2	1.5	1.4	-0.5
Short access day 1 total infusions	1.0	1.9	2.8	-1.2	-1.4	-1.6	-1.7	0.9
Short access day 10 total infusions	0.1	0.2	0.5	-0.7	-0.3	0.2	0.3	-0.5
Short access total infusions	0.8	1.2	2.2	-1.5	-1.2	-1.1	-1.0	0.3
Short access day 1 locomotion	0.8	1.3	2.2	-0.7	-0.9	-1.4	-1.5	1.0
Short access day 10 total locomotion	0.3	1.3	2.3	-1.2	-0.8	-1.5	-1.4	0.3
Short access total locomotion	0.8	1.2	2.3	-1.0	-0.9	-1.5	-1.4	0.3
One hour access (0.3 mA shock)	0.3	0.3	0.6	-0.2	0.0	0.6	0.8	-0.7
Compulsive drug intake	0.8	1.2	2.0	0.3	1.0	1.1	1.2	-1.4
One hour access (shock baseline)	0.1	0.2	0.5	-0.3	-0.2	0.3	0.5	-0.7
Social response proportion	0.7	0.9	2.5	-0.3	-1.0	-0.5	-0.8	1.6
Social responses	0.3	0.4	0.7	-0.4	-0.3	-0.6	-0.9	0.8
Social time	0.2	0.3	0.7	0.8	0.2	0.2	-0.0	0.8
Soleus weight	1.1	3.2	6.1	0.9	2.3	1.2	1.4	-2.5
Bone: stiffness	3.1	5.6	15.2	3.9	1.7	2.2	2.0	0.9
Tibialis anterior weight	0.3	1.1	2.3	0.7	0.9	0.9	1.1	-1.5
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.4	-0.9	-0.8	-0.3	-0.4	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.2	-0.6	-0.3	-0.3	0.4
Time to tail flick, test, before self-admin	1.3	1.5	3.1	-1.8	-1.5	-0.8	-0.7	1.0
Time to tail flick, test, after self-admin	4.1	4.4	5.0	-2.2	-2.2	-2.1	-2.1	1.7
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	2.8	0.5	0.3	0.6	0.8	-1.7
Delta time to tail flick, test, before/after SA	0.4	0.5	0.9	0.7	0.0	-0.9	-0.9	0.5
Tibia length	10.7	29.7	55.5	7.5	7.1	4.5	4.4	-1.8
Ambulatory time before self-admin	0.1	0.2	0.7	0.4	0.8	0.2	0.1	0.4
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	-0.3	0.3	0.3	-0.1
Bone: tissue strength	4.4	4.6	8.7	2.9	2.0	2.4	2.2	0.5
Total heroin consumption	1.1	1.2	3.8	1.9	0.0	0.0	-0.1	1.6
Bone: trabecular number	0.1	0.2	0.7	-0.3	0.4	-0.2	-0.1	-0.8
Bone: trabecular spacing	0.9	1.3	3.3	0.8	-0.1	1.8	1.5	0.3
Bone: trabecular thickness	0.4	0.6	1.9	0.6	1.4	-0.5	-0.3	-0.5
Bone: trabecular tissue density	0.6	1.0	2.4	-0.4	-1.4	-0.4	-0.6	1.5
Water consumed over 24 hours	0.3	0.5	1.1	-0.7	0.3	-0.8	-0.7	-1.0
Number of responses in last shaping day	0.6	0.8	1.3	-0.8	-0.9	-1.1	-1.0	0.5