Hub : Genes

Zfp933l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Zfp933l1 0.05 0.03 1.9e-06 0.05 0.06 0.06 0.06 2.8e-05 6.1e-06 6.1e-06 5.3e-06
2 Adipose gene expression Zfp933l1 0.04 0.03 1.6e-06 0.05 0.06 0.06 0.06 4.2e-06 5.2e-07 4.1e-07 6.8e-07
3 PL gene expression Zfp933l1 0.05 0.05 2.2e-04 0.02 0.02 0.03 0.02 5.3e-03 2.0e-03 2.3e-04 4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.81.42.31.5-1.1-0.8
Area under the delay curve0.40.61.00.5-0.7-1.0
BMI with tail25.789.7101.910.1-9.5-8.7
BMI without tail10.958.366.18.1-7.7-7.0
Body weight20.690.0106.610.3-9.4-8.6
Weight adjusted by age2.57.38.02.8-2.8-2.4
Bone surface0.81.62.51.6-1.2-1.0
Bone volume2.65.16.42.5-2.3-1.9
Breakpoint value in progressive ratio session1.93.54.92.2-1.4-1.9
Number of licking bursts0.00.10.2-0.00.40.3
Context. condit. distance diff. score0.20.20.3-0.50.50.5
Locomotion velocity, session 11.92.22.3-1.41.51.4
Locomotion distance, session 11.82.43.0-1.71.51.3
Locomotion velocity, session 21.01.21.6-1.31.01.1
Locomotion distance, session 20.20.30.40.5-0.7-0.5
Locomotion velocity, session 32.32.73.2-1.81.71.4
Locomotion distance, session 31.31.51.8-1.31.21.1
Stereotopy head waving bouts, day 30.00.10.1-0.40.10.0
Stereotopy head waving duration, day 30.00.00.1-0.1-0.1-0.3
Locomotion velocity, session 70.20.20.2-0.40.40.4
Locomotion distance, session 70.00.00.10.1-0.3-0.1
Stereotopy head waving bouts, day 70.10.10.30.30.1-0.5
Stereotopy head waving duration, day 70.10.20.5-0.10.7-0.1
Locomotion velocity, session 83.34.04.5-1.92.12.0
Locomotion distance, session 81.11.71.8-1.31.21.3
Degree of sensitization distance1.71.92.21.5-1.5-1.1
Degree of sensitization stereotypy0.20.20.30.60.0-0.5
Conditioned locomotion0.00.00.1-0.20.30.1
Cocaine response after cond. corrected1.42.13.6-1.90.91.3
Cocaine response after cond. not corrected2.73.95.2-2.31.62.0
Cocaine response before conditioning0.60.81.1-0.41.01.0
Saline control response0.00.10.1-0.4-0.10.1
Bone: connectivity density0.10.10.2-0.10.40.4
Bone: cortical apparent density6.29.812.2-3.52.92.9
Bone: cortical area9.415.318.54.3-3.9-3.4
Bone: cortical porosity0.30.30.50.7-0.4-0.4
Bone: cortical porosity1.41.52.21.5-1.1-1.1
Bone: cortical thickness7.212.013.23.6-3.6-3.1
Bone: cortical thickness9.511.713.03.3-3.6-3.4
Bone: cortical tissue density7.211.413.9-3.73.23.2
Condit. Reinf. active minus inactive responses2.52.83.2-1.51.71.8
Condit. Reinf. active-inactive response ratio2.72.83.1-1.61.71.7
Condit. Reinf. active responses0.20.30.5-0.20.50.7
Condit. Reinf. inactive responses0.81.01.61.3-1.0-0.7
Incentive salience index mean1.41.82.1-1.21.31.5
Condit. Reinf. lever presses0.50.80.9-0.90.90.9
Condit. Reinf. active minus inactive responses0.60.91.51.2-0.7-0.8
Condit. Reinf. active-inactive response ratio1.32.12.71.6-1.2-1.4
Condit. Reinf. active responses0.71.01.81.3-0.8-0.8
Condit. Reinf. inactive responses0.10.20.50.7-0.3-0.1
Condit. Reinf. lever presses1.01.52.01.4-1.2-1.0
Condit. Reinf. lever reinforcers received0.20.30.60.8-0.3-0.2
Conditioned reinforcement - actives0.41.81.8-1.41.31.3
Conditioned reinforcement - inactives0.41.11.4-0.91.21.0
Conditioned locomotion1.82.72.9-1.71.61.6
Patch foraging indifference point 0 sec3.29.09.43.1-3.0-2.9
Patch foraging indifference point AUC0.10.10.30.2-0.3-0.5
Delay disc. indifference point, 0s delay1.11.31.51.0-1.2-1.2
Delay disc. indifference point, 16s delay0.10.20.40.3-0.3-0.6
Delay disc. indifference point, 2s delay0.10.20.3-0.1-0.4-0.6
Delay disc. indifference point, 24s delay0.50.81.20.6-0.9-1.1
Delay disc. indifference point, 4s delay0.40.40.60.5-0.5-0.8
Delay disc. indifference point, 8s delay0.10.20.40.1-0.3-0.6
Indifference point function ln k0.10.30.40.6-0.6-0.3
Indifference point function log k0.10.30.40.6-0.6-0.3
Patch foraging total patch changes 0 sec3.911.512.03.5-3.5-3.2
Patch foraging total patch changes 12 sec3.54.74.92.1-2.2-2.2
Patch foraging total patch changes 18 sec1.22.83.01.7-1.7-1.7
Patch foraging total patch changes 24 sec0.20.81.00.7-0.8-1.0
Patch foraging total patch changes 6 sec4.17.07.22.6-2.7-2.6
Patch foraging time to switch 0 sec0.62.22.5-1.61.51.4
Patch foraging water rate 0 sec1.34.95.22.3-2.2-2.1
Patch foraging water rate 12 sec1.14.45.22.3-2.1-1.9
Patch foraging water rate 18 sec1.43.03.71.6-1.9-1.7
Patch foraging water rate 24 sec5.57.89.72.6-3.1-2.6
Patch foraging water rate 6 sec2.94.35.32.0-2.3-1.9
Seeking ratio, delayed vs. immediate footshock9.113.114.4-3.83.53.5
Distance traveled before self-admin0.30.61.3-1.10.30.6
Distance traveled after self-admin0.91.62.0-1.41.40.9
Extensor digitorum longus weight1.56.17.32.7-2.6-2.0
Bone: elastic displacement0.50.60.80.6-0.9-0.9
Bone: elastic work4.05.36.62.0-2.6-2.3
Bone: endosteal estimation0.92.33.11.8-1.5-1.3
Bone: endosteal perimeter2.45.87.22.7-2.3-2.2
Epididymis fat weight14.673.593.29.7-8.3-7.6
Delta time in closed arm before/after self-admin0.10.00.1-0.4-0.00.1
Delta time in open arm before/after self-admin0.20.20.60.8-0.1-0.1
Diff in mean of infusions in LGA sessions0.91.72.31.5-1.0-1.4
Delay discount exponential model param0.50.71.2-0.50.81.1
Extinction: sum of active levers before priming0.30.40.60.8-0.2-0.7
Active lever presses in extinction session 65.15.15.82.1-2.3-2.4
Bone: final force8.113.214.53.8-3.8-3.3
Bone: final moment8.113.114.73.8-3.8-3.2
Food consumed during 24 hour testing period0.20.40.50.7-0.7-0.5
Glucose6.610.412.33.5-3.1-3.1
Heart weight10.917.622.04.7-4.1-3.7
Delay discount hyperbolic model param0.60.71.2-0.50.81.1
Intermittent access intake day 1-15 change0.00.00.0-0.2-0.1-0.2
Intermittent access intake escalation0.00.00.0-0.1-0.1-0.2
Intermittent access intake escalation 20.20.30.40.5-0.6-0.5
Intermitt. access day 1 inactive lever presses0.10.81.41.2-0.7-0.8
Intermitt. access day 15 inactive lever presses0.52.53.01.7-1.5-1.6
Intermitt. access escalation Index0.20.50.5-0.70.70.7
Intermittent access day 1 total infusions0.10.20.2-0.50.40.4
Intermittent access day 15 total infusions0.00.00.1-0.20.1-0.0
Intermittent access terminal intake (last 3 days)0.00.00.0-0.1-0.1-0.2
Intermittent access total infusions0.30.30.4-0.60.60.5
Intermittent access day 1 locomotion0.30.50.8-0.90.70.7
Intermittent access day 15 total locomotion0.00.00.00.00.1-0.1
Intermittent access total locomotion0.40.50.7-0.80.60.6
Intermittent access standard deviation0.10.50.70.7-0.6-0.8
Left kidney weight5.443.447.56.9-6.9-6.0
Right kidney weight7.653.260.97.5-7.8-6.6
Cocaine induced anxiety0.82.22.8-1.71.41.4
Post-drug Anxiety0.10.10.2-0.20.50.4
Baseline Anxiety0.81.42.51.6-0.8-1.0
Tail length0.10.71.11.1-0.7-0.6
Length with tail1.46.48.73.0-2.4-2.1
Length without tail1.68.612.23.5-2.7-2.5
Times rat made contact with spout1.11.21.51.2-1.2-0.9
Lifetime Intake0.40.50.6-0.80.70.6
Liver weight, left9.816.918.64.3-4.2-3.8
Liver weight, right3.86.67.42.7-2.7-2.2
Locomotor activity0.20.30.4-0.50.40.6
Locomotor testing distance0.30.70.9-1.00.60.9
Locomotor testing rearing0.10.40.70.4-0.9-0.5
Locomotion in novel chamber0.40.50.90.4-1.0-0.7
Locomotion in novel chamber post-restriction0.10.40.90.3-0.6-0.9
Fecal boli incidents, locomotor time 10.00.00.00.1-0.0-0.1
Change in fecal boli incidents, locomotor task0.50.50.70.9-0.7-0.6
Time >=10cm from walls, locomotor time 10.10.20.2-0.30.40.4
Bouts of movement, locomotor time 10.10.20.30.5-0.4-0.3
Total resting periods, locomotor time 10.20.30.30.6-0.6-0.4
Rest time, locomotor task time 10.81.32.11.0-1.4-1.0
Distance moved, locomotor task time 10.00.10.1-0.30.3-0.0
Vertical activity count, locomotor time 10.00.30.4-0.60.70.4
Time >=10cm from walls, locomotor time 20.10.20.40.3-0.6-0.3
Bouts of movement, locomotor time 20.00.10.1-0.30.20.3
Total resting periods, locomotor time 20.00.10.1-0.30.10.2
Rest time, locomotor task time 20.00.00.0-0.1-0.10.1
Distance moved, locomotor task time 20.00.00.0-0.1-0.1-0.2
Vertical activity count, locomotor time 20.10.10.2-0.40.40.3
Light reinforcement 10.00.10.1-0.4-0.10.2
Light reinforcement 20.40.91.1-0.90.91.0
Bone: marrow area1.12.73.61.9-1.6-1.4
Bone: maximum diameter3.57.19.93.1-2.5-2.3
Bone: maximum force4.69.210.33.2-3.2-2.6
Bone: maximum moment4.78.810.23.2-3.1-2.5
Mean time between licks in bursts0.31.61.9-1.01.41.4
Mean num. licks in bursts0.41.01.60.8-1.3-1.0
Cd content in liver0.20.20.50.0-0.7-0.2
Co content in liver0.70.81.30.6-1.1-0.9
Cu content in liver0.10.20.20.3-0.5-0.4
Fe content in liver0.00.10.10.30.20.2
K content in liver0.10.10.10.3-0.3-0.3
Mg content in liver0.80.91.30.7-1.1-0.9
Mn content in liver1.11.21.60.9-1.3-1.1
Na content in liver2.73.13.61.6-1.7-1.9
Rb content in liver0.10.10.10.3-0.3-0.3
Se content in liver0.10.10.2-0.50.30.3
Sr content in liver0.80.71.6-1.20.60.6
Zn content in liver0.10.10.1-0.2-0.4-0.1
Bone: minimum diameter4.68.811.33.4-2.9-2.6
Time in familiar zone, hab. session 12.62.93.01.7-1.6-1.7
Time in novel zone, hab. session 15.96.57.5-2.42.72.6
Total zone transitions, hab. session 10.10.20.30.2-0.4-0.5
Total locomotion distance, hab. session 10.20.30.4-0.40.70.5
Locomotion velocity, hab. session 10.10.10.1-0.20.40.4
Time in familiar zone, hab. session 20.81.01.5-0.71.20.9
Time in novel zone, hab. session 20.40.40.60.6-0.8-0.6
Total zone transitions, hab. session 20.20.30.30.4-0.5-0.6
Total locomotion distance, hab. session 20.30.40.50.7-0.6-0.5
Locomotion velocity, hab. session 20.60.80.90.9-0.9-0.8
Novel to familiar place preference ratio0.50.60.8-0.50.90.9
Novelty place preference0.50.60.8-0.50.90.9
Time in novel zone, NPP test0.70.91.2-0.51.11.0
Total zone transitions, NPP test0.30.50.70.6-0.9-0.6
Total locomotion distance, NPP test0.10.10.10.2-0.4-0.2
Locomotion velocity, NPP test0.10.20.50.2-0.7-0.4
Intraocular pressure0.10.20.4-0.20.60.3
Delta distance traveled before/after self-admin0.20.30.6-0.30.80.3
Delta ambulatory time before/after self-admin0.10.20.3-0.30.60.3
Parametrial fat weight27.163.976.88.8-8.0-7.1
Pavlov. Cond. lever latency0.50.60.7-0.80.80.7
Pavlov. Cond. magazine entry latency0.30.40.50.7-0.6-0.5
Pavlov. Cond. change in total contacts1.21.31.91.4-1.0-1.0
Pavlov. Cond. index score0.70.81.11.0-0.9-0.8
Pavlov. Cond. latency score0.60.70.90.9-0.8-0.7
Pavlov. Cond. lever contacts1.01.21.31.2-1.1-1.0
Pavlov. Cond. magazine entry number0.50.60.8-0.90.80.6
Pavlov. Cond. intertrial magazine entries1.11.41.71.3-1.2-1.0
Pavlov. Cond. lever-magazine prob. diff.0.60.81.11.0-0.9-0.7
Pavlov. Cond. response bias0.50.60.70.8-0.8-0.7
Pavlov. Cond. lever latency0.20.20.5-0.70.30.2
Pavlov. Cond. magazine entry latency0.20.30.7-0.30.80.4
Pavlov. Cond. change in total contacts0.00.00.10.3-0.0-0.0
Pavlov. Cond. index score0.00.00.00.20.20.1
Pavlov. Cond. latency score0.00.00.10.20.10.0
Pavlov. Cond. lever contacts0.20.20.50.7-0.4-0.3
Pavlov. Cond. magazine entry number0.10.10.20.1-0.4-0.1
Pavlov. Cond. intertrial magazine entries2.45.36.92.2-2.6-2.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.10.30.1
Pavlov. Cond. response bias0.00.10.10.30.20.2
Time in closed arm before self-admin0.00.00.0-0.00.00.0
Time in closed arm after self-admin0.10.10.3-0.50.10.4
Time in open arm before self-admin1.31.61.8-1.41.21.2
Time in open arm after self-admin0.20.20.50.10.70.3
Bone: periosteal estimation5.212.415.23.9-3.6-3.1
Bone: periosteal perimeter8.616.920.24.5-4.1-3.7
Bone: post-yield work0.00.10.10.3-0.00.2
Progressive ratio test 1 active lever presses0.30.50.7-0.80.60.5
Progressive ratio test 1 breakpoint0.20.30.5-0.70.50.4
Progressive ratio test 1 inactive lever presses0.10.20.3-0.40.50.4
Progressive ratio test 2 active lever presses0.10.10.20.2-0.4-0.4
Progressive ratio test 2 breakpoint0.10.10.10.2-0.3-0.4
Progressive ratio test 2 inactive lever presses0.00.10.1-0.10.20.3
Incentive Sensitization - Responses0.30.80.90.8-0.9-0.9
Incentive Sensitization - Breakpoint0.20.50.50.7-0.7-0.7
Sum of active levers in priming session hrs 5-60.40.40.50.5-0.6-0.7
Progressive ratio0.71.92.8-1.71.31.1
Food seeking constrained by brief footshock3.24.05.3-2.31.81.8
Seeking ratio, punishment vs. effort0.00.00.1-0.2-0.10.3
Retroperitoneal fat weight24.4109.4132.711.5-10.3-9.4
Reaction time number correct0.10.30.50.7-0.4-0.4
Reaction time mean minus median0.00.20.30.2-0.4-0.6
Reaction time mean minus median AUC0.10.81.10.5-1.0-1.1
Reaction time num false alarms0.10.20.20.4-0.5-0.3
Reaction time num false alarms AUC0.20.50.60.8-0.8-0.6
Reaction time trials correct on left0.10.30.50.7-0.4-0.4
Reaction time trials on left0.10.20.40.7-0.4-0.4
Reaction time mean0.51.21.6-1.31.20.7
Reaction time mean AUC0.51.11.6-1.31.10.7
Median of all reaction times1.32.02.6-1.61.51.0
Reaction time omissions0.10.20.4-0.40.70.3
Reaction time false alarm rate0.10.10.20.3-0.4-0.4
Reaction time premature initiation rate0.00.00.1-0.30.0-0.0
Reaction time premature initiations0.10.20.20.3-0.4-0.4
Std. dev. reaction times0.00.10.10.1-0.1-0.4
Reaction time trials completed0.10.20.40.7-0.4-0.4
Reaction time trials AUC0.10.50.80.9-0.6-0.5
Run reversals in cocaine runway, females0.60.61.2-0.61.10.6
Run reversals in cocaine runway, males0.10.10.2-0.3-0.4-0.1
Latency to leave start box in cocaine runway0.00.00.0-0.10.20.2
Latency to leave start box in cocaine runway, F0.10.10.10.3-0.3-0.2
Latency to leave start box in cocaine runway, M0.00.00.00.2-0.0-0.2
Std. dev. time between licks in bursts1.93.63.9-1.82.02.0
Total sessions with >9 infusions1.01.21.9-1.40.90.9
Short access day 1 total inactive lever presses1.12.12.5-1.31.51.6
Short access day 10 total inactive lever presses0.42.73.11.7-1.8-1.4
Short access day 1 total infusions0.51.01.2-1.10.90.9
Short access day 10 total infusions0.81.41.5-1.21.21.1
Short access total infusions1.11.52.0-1.41.11.1
Short access day 1 locomotion0.00.00.1-0.30.10.1
Short access day 10 total locomotion0.00.10.3-0.50.30.2
Short access total locomotion0.71.11.9-1.40.90.8
One hour access (0.3 mA shock)0.50.60.8-0.60.90.7
Compulsive drug intake0.00.00.10.10.30.2
One hour access (shock baseline)0.20.60.8-0.90.70.7
Social response proportion0.00.10.2-0.10.00.4
Social responses0.91.21.41.2-1.1-0.9
Social time0.10.20.20.5-0.4-0.4
Soleus weight4.413.014.63.5-3.8-3.5
Bone: stiffness1.83.33.81.9-2.0-1.5
Tibialis anterior weight0.20.60.80.9-0.9-0.5
Time to tail flick, vehicle, before self-admin0.00.10.10.00.20.3
Time to tail flick, vehicle, after self-admin0.10.30.40.5-0.4-0.7
Time to tail flick, test, before self-admin0.20.20.4-0.70.30.3
Time to tail flick, test, after self-admin0.70.81.0-0.70.81.0
Delta time to tail flick, vehicle, before/after SA1.81.92.61.4-1.1-1.6
Delta time to tail flick, test, before/after SA0.00.00.10.1-0.00.4
Tibia length0.20.50.50.7-0.6-0.7
Ambulatory time before self-admin0.10.40.9-0.90.30.4
Ambulatory time after self-admin0.91.52.0-1.41.30.9
Bone: tissue strength0.30.30.4-0.50.60.5
Total heroin consumption7.08.29.83.1-2.5-2.9
Bone: trabecular number0.50.91.31.2-0.9-0.7
Bone: trabecular spacing3.65.25.4-2.32.32.3
Bone: trabecular thickness9.513.215.23.9-3.5-3.4
Bone: trabecular tissue density1.72.93.2-1.81.71.7
Water consumed over 24 hours0.51.01.40.9-1.2-0.9
Number of responses in last shaping day0.50.61.0-1.00.70.7