Hub : Genes

Zfp821

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_056985050.2	0.04	0.02	5.1e-04	0.05	0.03	0.03	0.03	3.2e-05	1.1e-03	6.6e-04	6.1e-04
2	Brain	intron excision ratio	chr19_54590998_54592473	0.06	0.03	6.2e-06	0.07	0.04	0.04	0.06	7.0e-07	2.0e-04	9.0e-05	7.8e-06
3	Liver	mRNA stability	Zfp821	0.06	0.03	8.2e-06	0.06	0.05	0.04	0.06	4.9e-07	5.4e-06	1.4e-05	8.7e-07
4	NAcc	gene expression	Zfp821	0.03	0.01	2.8e-03	-0	0	0	-0	8.0e-01	5.9e-02	2.1e-01	7.7e-01
5	Eye	intron excision ratio	chr19_54601875_54604713	0.38	0.16	6.3e-03	0.1	0.16	0.14	0.15	1.4e-02	2.2e-03	3.8e-03	2.8e-03
6	Eye	intron excision ratio	chr19_54601894_54604713	0.36	0.16	9.5e-03	0.09	0.13	0.1	0.13	1.6e-02	4.4e-03	1.2e-02	4.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.4	0.6	0.4	0.2	-0.3	-0.6	0.6
Area under the delay curve	0.5	0.6	1.3	-0.1	-0.0	-1.1	0.7	-0.9	0.9
BMI with tail	0.2	0.8	2.4	-1.1	-1.0	1.6	-0.1	0.4	-0.4
BMI without tail	0.2	0.7	1.6	-1.1	-1.0	1.3	-0.1	0.4	-0.5
Body weight	0.7	2.9	6.6	-2.6	-2.6	0.9	1.1	1.1	-1.1
Weight adjusted by age	0.1	0.1	0.3	-0.2	-0.5	0.2	0.5	-0.3	0.2
Bone surface	0.4	0.7	1.5	-1.1	-1.2	0.2	0.9	0.6	-0.6
Bone volume	0.2	0.4	1.1	-0.9	-1.1	0.0	0.7	0.3	-0.3
Breakpoint value in progressive ratio session	0.8	1.0	2.8	0.3	0.2	-0.6	0.2	-1.7	1.7
Number of licking bursts	0.2	0.2	0.6	-0.1	0.0	-0.8	-0.3	-0.6	0.6
Context. condit. distance diff. score	0.3	0.3	0.7	-0.8	-0.6	-0.8	0.6	0.1	-0.1
Locomotion velocity, session 1	0.8	0.9	2.4	0.4	0.3	-0.4	0.3	-1.6	1.5
Locomotion distance, session 1	0.8	1.1	2.2	1.0	1.0	0.1	-0.4	-1.5	1.4
Locomotion velocity, session 2	0.3	0.4	0.8	0.6	0.3	-0.7	-0.2	-0.8	0.9
Locomotion distance, session 2	0.1	0.1	0.6	-0.0	-0.0	0.7	0.2	0.2	-0.2
Locomotion velocity, session 3	2.5	2.9	5.2	1.9	1.7	0.1	-0.8	-2.3	2.2
Locomotion distance, session 3	0.2	0.2	0.5	0.5	0.3	0.2	0.2	-0.7	0.7
Stereotopy head waving bouts, day 3	3.3	3.8	5.9	2.0	1.9	-1.7	-0.9	-2.4	2.4
Stereotopy head waving duration, day 3	2.5	2.9	5.2	1.4	1.4	-1.8	-0.3	-2.2	2.3
Locomotion velocity, session 7	0.8	0.9	2.0	0.9	0.9	-0.1	0.3	-1.4	1.4
Locomotion distance, session 7	0.4	0.5	1.7	-0.7	-0.6	0.1	1.3	-0.5	0.4
Stereotopy head waving bouts, day 7	5.6	6.3	10.1	2.6	2.5	-0.9	-1.9	-3.2	3.2
Stereotopy head waving duration, day 7	5.5	6.6	8.7	2.9	2.8	-1.0	-2.3	-2.9	2.9
Locomotion velocity, session 8	0.8	0.9	1.3	-1.0	-1.1	-0.6	1.1	0.9	-0.8
Locomotion distance, session 8	0.1	0.2	0.5	-0.6	-0.5	-0.2	0.7	0.1	-0.1
Degree of sensitization distance	0.4	0.4	1.0	-1.0	-0.7	0.2	0.7	0.4	-0.4
Degree of sensitization stereotypy	5.0	5.5	7.7	2.6	2.5	-0.3	-2.1	-2.8	2.8
Conditioned locomotion	0.2	0.2	0.6	0.1	0.3	0.8	-0.8	0.1	-0.1
Cocaine response after cond. corrected	0.5	0.7	1.5	0.4	0.4	1.2	-0.5	0.9	-1.0
Cocaine response after cond. not corrected	0.3	0.4	0.9	0.2	0.2	1.0	-0.2	0.7	-0.8
Cocaine response before conditioning	0.4	0.5	1.0	-0.4	-0.3	-1.0	0.9	-0.7	0.7
Saline control response	0.8	1.1	3.7	-1.0	-0.8	-1.9	0.9	-0.5	0.6
Bone: connectivity density	0.0	0.1	0.1	-0.0	-0.1	0.2	0.1	-0.4	0.3
Bone: cortical apparent density	0.3	0.5	1.2	0.3	0.2	-0.1	-0.4	-1.1	1.1
Bone: cortical area	0.9	1.4	2.2	-1.2	-1.5	0.7	0.8	1.3	-1.3
Bone: cortical porosity	1.1	1.2	3.4	-0.6	-0.6	-1.7	1.8	-0.3	0.4
Bone: cortical porosity	1.2	1.3	3.2	-0.5	-0.4	-1.7	1.8	-0.8	0.8
Bone: cortical thickness	0.3	0.5	0.9	-0.1	-0.2	0.9	-0.4	0.9	-0.9
Bone: cortical thickness	0.4	0.5	1.2	-0.1	-0.3	0.7	0.1	1.1	-1.1
Bone: cortical tissue density	0.3	0.5	1.3	0.2	0.2	-0.1	-0.3	-1.1	1.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.1	-0.0	0.7	0.5	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	-0.2	-0.1	0.6	0.3	0.9	-0.9
Condit. Reinf. active responses	0.5	0.6	2.6	-0.9	-0.7	-0.1	1.6	0.1	-0.1
Condit. Reinf. inactive responses	1.4	1.7	4.9	-1.4	-1.4	-1.1	2.2	-0.4	0.4
Incentive salience index mean	0.4	0.6	1.1	-0.8	-0.7	0.4	1.1	0.7	-0.7
Condit. Reinf. lever presses	0.8	1.1	1.7	-1.3	-1.2	-0.1	1.3	0.9	-0.9
Condit. Reinf. active minus inactive responses	2.0	2.6	6.7	-0.7	-0.7	-2.1	2.6	-1.3	1.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	0.4	0.4	-0.8	0.8	-0.9	0.9
Condit. Reinf. active responses	3.0	4.1	10.0	-1.2	-1.3	-2.9	3.2	-1.3	1.3
Condit. Reinf. inactive responses	1.9	2.4	5.0	-1.5	-1.5	-2.0	2.2	-0.5	0.6
Condit. Reinf. lever presses	2.3	3.2	7.1	-1.6	-1.6	-2.7	2.5	-0.5	0.6
Condit. Reinf. lever reinforcers received	3.1	4.4	10.1	-1.4	-1.4	-3.0	3.2	-1.3	1.3
Conditioned reinforcement - actives	0.8	1.3	3.9	1.2	0.9	2.0	-0.9	-0.8	0.7
Conditioned reinforcement - inactives	0.6	0.8	2.8	0.5	0.3	1.7	-0.9	-0.7	0.7
Conditioned locomotion	0.9	1.1	6.0	0.6	0.4	2.4	-0.5	-0.1	-0.0
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.1	-0.0	-0.4	-0.5	0.1	-0.0
Patch foraging indifference point AUC	1.8	2.6	5.0	0.6	0.7	-2.2	0.2	-2.2	2.2
Delay disc. indifference point, 0s delay	0.5	0.6	1.5	0.9	0.9	-1.2	0.0	-0.4	0.4
Delay disc. indifference point, 16s delay	0.4	0.5	1.1	0.3	0.5	-0.5	-0.2	-1.0	1.0
Delay disc. indifference point, 2s delay	0.7	0.8	1.9	-0.4	-0.8	-1.4	1.4	-0.4	0.4
Delay disc. indifference point, 24s delay	0.5	0.6	1.7	-1.3	-1.1	-0.2	0.7	0.2	-0.2
Delay disc. indifference point, 4s delay	1.1	1.1	1.7	1.0	0.9	-1.2	0.3	-1.3	1.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	-0.1	0.0	-0.6	0.0	-0.9	0.9
Indifference point function ln k	1.8	3.2	6.0	-1.6	-1.7	1.2	0.7	2.4	-2.5
Indifference point function log k	1.8	3.2	6.0	-1.6	-1.7	1.2	0.7	2.4	-2.5
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	-0.1	-0.2	-0.5	-0.3	0.1	-0.1
Patch foraging total patch changes 12 sec	0.3	0.4	1.5	-0.0	-0.0	-1.2	0.1	-0.6	0.7
Patch foraging total patch changes 18 sec	0.4	0.6	1.4	1.0	1.2	0.0	-0.7	-0.5	0.5
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	-0.0	-0.2	-0.4	-0.5	-0.4	0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	-0.3	-0.6	-0.2	-0.4	-0.4	0.5
Patch foraging time to switch 0 sec	0.5	1.0	3.7	0.5	0.6	1.9	-0.9	0.6	-0.7
Patch foraging water rate 0 sec	0.1	0.3	0.7	-0.3	-0.1	-0.6	-0.0	-0.8	0.8
Patch foraging water rate 12 sec	0.1	0.2	0.4	-0.4	-0.4	-0.5	-0.3	-0.5	0.6
Patch foraging water rate 18 sec	0.4	0.6	1.8	-1.3	-1.4	-0.1	0.3	0.1	-0.0
Patch foraging water rate 24 sec	0.2	0.3	0.7	0.2	0.4	-0.9	0.0	-0.7	0.7
Patch foraging water rate 6 sec	0.9	1.4	3.5	-0.2	-0.2	-1.1	-0.2	-1.8	1.9
Seeking ratio, delayed vs. immediate footshock	1.7	2.1	6.4	1.1	1.4	2.5	-1.7	0.4	-0.5
Distance traveled before self-admin	0.9	1.2	2.6	-0.7	-0.6	-1.1	-0.0	-1.5	1.6
Distance traveled after self-admin	0.3	0.4	1.0	0.0	0.1	-0.6	-0.6	-0.9	1.0
Extensor digitorum longus weight	0.7	2.7	4.3	-2.1	-2.0	-1.7	1.7	1.0	-0.9
Bone: elastic displacement	0.6	0.7	1.0	1.0	0.9	0.7	-1.0	0.7	-0.7
Bone: elastic work	0.8	1.1	2.5	0.1	-0.2	1.2	-0.3	1.6	-1.6
Bone: endosteal estimation	1.3	2.9	5.6	-2.4	-2.4	0.2	2.0	1.1	-1.0
Bone: endosteal perimeter	1.2	2.5	4.6	-2.0	-2.2	0.4	1.8	1.2	-1.2
Epididymis fat weight	0.5	1.7	4.3	-2.0	-2.1	0.4	1.2	0.4	-0.4
Delta time in closed arm before/after self-admin	1.5	1.4	3.1	1.4	1.1	1.5	-1.8	-0.2	0.1
Delta time in open arm before/after self-admin	1.3	1.2	2.9	-1.1	-0.8	-1.7	1.3	-0.7	0.7
Diff in mean of infusions in LGA sessions	0.4	0.5	0.9	-0.1	-0.1	0.9	-0.5	0.9	-0.9
Delay discount exponential model param	0.4	0.5	1.0	0.4	0.3	1.0	-0.9	0.6	-0.6
Extinction: sum of active levers before priming	1.1	1.3	2.4	0.3	0.2	-1.5	1.2	-1.3	1.4
Active lever presses in extinction session 6	0.6	0.6	1.2	0.7	0.8	-0.4	0.3	-1.1	1.1
Bone: final force	1.8	2.9	4.6	-1.8	-1.8	0.5	1.2	2.2	-2.1
Bone: final moment	1.7	2.8	4.8	-1.6	-1.7	0.7	1.1	2.2	-2.2
Food consumed during 24 hour testing period	0.3	0.5	1.0	-0.7	-0.8	-0.9	1.0	-0.1	0.2
Glucose	1.4	2.2	3.7	-1.6	-1.5	-0.2	1.9	1.6	-1.6
Heart weight	0.9	1.5	3.7	-1.7	-1.9	-0.7	1.3	-0.2	0.2
Delay discount hyperbolic model param	0.4	0.5	1.1	0.2	0.2	1.0	-0.8	0.7	-0.7
Intermittent access intake day 1-15 change	0.2	0.5	1.2	1.1	0.7	0.5	-0.8	-0.3	0.3
Intermittent access intake escalation	0.2	0.4	0.8	0.9	0.5	0.4	-0.6	-0.6	0.6
Intermittent access intake escalation 2	0.3	0.4	0.7	0.5	0.4	0.1	-0.6	-0.8	0.8
Intermitt. access day 1 inactive lever presses	0.2	0.6	2.3	0.7	0.7	1.5	-0.1	0.4	-0.5
Intermitt. access day 15 inactive lever presses	0.3	0.7	3.1	0.1	0.1	1.8	-0.3	-0.7	0.6
Intermitt. access escalation Index	0.1	0.1	0.4	0.0	0.5	-0.6	0.0	-0.2	0.2
Intermittent access day 1 total infusions	1.7	2.7	6.0	2.4	2.3	1.2	-0.9	-1.2	1.0
Intermittent access day 15 total infusions	1.1	1.7	3.3	1.7	1.4	1.8	-0.8	-0.8	0.6
Intermittent access terminal intake (last 3 days)	1.7	2.2	4.3	1.9	1.9	2.1	-1.2	-0.5	0.3
Intermittent access total infusions	1.2	1.5	3.2	1.6	1.5	1.8	-0.5	-0.5	0.3
Intermittent access day 1 locomotion	0.8	1.0	2.6	1.6	1.3	1.1	-0.5	-0.6	0.5
Intermittent access day 15 total locomotion	1.2	2.3	3.8	1.8	1.6	1.9	-1.6	-0.9	0.8
Intermittent access total locomotion	2.0	2.4	4.1	2.0	1.8	2.0	-1.5	-0.7	0.6
Intermittent access standard deviation	0.5	1.0	2.9	0.2	0.1	0.4	0.1	-1.7	1.6
Left kidney weight	2.7	12.4	28.0	-5.3	-5.3	-0.2	3.6	1.7	-1.6
Right kidney weight	2.1	9.8	24.5	-4.9	-4.9	-0.5	3.0	0.7	-0.6
Cocaine induced anxiety	0.1	0.1	0.4	-0.5	-0.6	-0.4	0.1	-0.0	0.1
Post-drug Anxiety	0.4	0.4	0.8	-0.3	-0.4	-0.7	0.1	-0.9	0.9
Baseline Anxiety	0.3	0.4	1.0	0.3	0.2	-0.6	-0.0	-1.0	1.0
Tail length	0.3	1.0	2.4	-1.5	-1.6	-0.6	1.1	0.1	-0.1
Length with tail	0.4	1.8	4.2	-1.9	-2.1	-0.6	1.5	0.4	-0.4
Length without tail	0.1	0.4	1.4	-0.9	-1.2	-0.4	0.5	0.1	-0.1
Times rat made contact with spout	0.4	0.4	1.0	0.8	1.0	0.9	-0.3	-0.3	0.2
Lifetime Intake	1.0	1.2	2.6	1.4	1.3	1.6	-0.3	-0.7	0.5
Liver weight, left	0.9	1.4	2.1	1.2	0.9	0.3	-1.4	-1.4	1.4
Liver weight, right	0.8	1.3	3.5	-1.9	-1.8	0.1	0.7	0.7	-0.6
Locomotor activity	0.5	0.7	1.5	-1.2	-1.1	0.3	0.5	-0.9	0.9
Locomotor testing distance	0.5	1.0	2.4	0.3	0.3	0.6	-0.6	-1.6	1.5
Locomotor testing rearing	0.6	1.1	3.4	0.0	-0.1	-0.3	-0.3	-1.8	1.8
Locomotion in novel chamber	1.1	1.4	1.8	1.2	1.0	1.1	-1.4	-1.2	1.2
Locomotion in novel chamber post-restriction	0.2	0.4	0.5	-0.7	-0.6	-0.3	0.6	-0.7	0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.3	-0.4	0.1	0.1	0.3	-0.3
Change in fecal boli incidents, locomotor task	0.9	0.9	1.2	-0.9	-1.1	-1.1	0.6	1.0	-0.9
Time >=10cm from walls, locomotor time 1	1.4	1.4	3.6	-0.5	-0.5	1.0	0.2	1.9	-1.9
Bouts of movement, locomotor time 1	0.4	0.5	2.4	0.5	0.4	-1.5	0.3	-0.1	0.1
Total resting periods, locomotor time 1	0.5	0.6	2.8	0.5	0.4	-1.7	0.5	0.2	-0.2
Rest time, locomotor task time 1	0.4	0.5	1.4	1.2	0.9	-0.7	-0.3	0.2	-0.2
Distance moved, locomotor task time 1	0.7	1.0	2.1	-1.4	-1.2	0.9	1.1	0.6	-0.7
Vertical activity count, locomotor time 1	0.2	0.5	1.1	-0.4	-0.3	1.1	-0.3	-1.0	0.9
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.7	0.6	0.4	0.3	0.3	0.8	-0.8
Bouts of movement, locomotor time 2	0.5	0.8	4.6	-0.3	-0.3	-2.2	0.2	0.1	0.0
Total resting periods, locomotor time 2	0.4	0.8	4.0	-0.5	-0.5	-2.0	0.3	0.2	-0.1
Rest time, locomotor task time 2	0.6	0.7	1.8	-0.3	-0.4	-0.4	0.4	1.4	-1.3
Distance moved, locomotor task time 2	0.3	0.4	0.8	-0.3	-0.4	0.3	0.5	-0.9	0.9
Vertical activity count, locomotor time 2	1.3	1.8	4.5	0.8	0.8	-0.5	-0.7	-2.1	2.1
Light reinforcement 1	0.7	1.8	5.3	-0.8	-1.0	-2.3	1.8	-0.4	0.5
Light reinforcement 2	0.9	1.4	4.4	-0.7	-0.7	-2.1	1.6	-0.5	0.6
Bone: marrow area	1.2	2.6	5.2	-2.3	-2.3	0.1	2.0	0.9	-0.9
Bone: maximum diameter	1.1	2.0	3.9	-1.7	-2.0	0.4	1.3	1.3	-1.3
Bone: maximum force	2.0	3.6	5.8	-2.3	-2.4	-0.1	2.0	1.8	-1.8
Bone: maximum moment	1.9	3.3	5.0	-2.1	-2.2	0.2	1.9	1.8	-1.8
Mean time between licks in bursts	0.1	0.2	0.3	0.5	0.5	-0.1	-0.5	-0.6	0.6
Mean num. licks in bursts	0.3	0.5	2.2	0.6	0.7	1.5	-0.0	0.3	-0.4
Cd content in liver	0.3	0.4	1.6	0.4	0.5	1.3	-0.2	0.1	-0.2
Co content in liver	1.9	2.2	4.2	2.0	2.0	1.2	-1.2	-1.1	0.9
Cu content in liver	0.1	0.2	0.3	-0.4	-0.6	-0.2	0.5	0.3	-0.3
Fe content in liver	1.1	1.3	2.1	1.5	1.2	-0.4	-0.7	-1.4	1.3
K content in liver	0.4	0.4	1.2	-0.7	-0.5	-0.7	1.1	0.1	-0.1
Mg content in liver	1.6	1.7	4.1	0.5	0.6	-2.0	0.7	-1.6	1.6
Mn content in liver	0.7	0.8	2.3	-0.7	-0.9	-1.1	1.5	0.2	-0.2
Na content in liver	0.2	0.2	0.4	-0.4	-0.3	-0.4	0.6	0.3	-0.3
Rb content in liver	1.7	1.9	4.0	1.1	1.2	-1.0	-0.0	-2.0	2.0
Se content in liver	0.1	0.2	0.6	0.2	-0.3	-0.8	0.6	0.1	-0.1
Sr content in liver	0.8	0.7	1.7	-1.2	-1.3	0.2	0.7	0.4	-0.4
Zn content in liver	0.5	0.6	1.0	1.0	0.9	0.6	-0.8	-0.6	0.5
Bone: minimum diameter	1.2	2.3	5.1	-2.2	-2.3	0.0	1.6	0.9	-0.8
Time in familiar zone, hab. session 1	3.3	3.2	7.5	0.4	0.5	-1.9	0.6	-2.7	2.7
Time in novel zone, hab. session 1	3.5	3.5	8.6	-0.9	-0.9	1.4	0.4	2.9	-2.9
Total zone transitions, hab. session 1	0.5	0.7	1.6	-1.1	-1.1	-0.0	1.3	-0.1	0.1
Total locomotion distance, hab. session 1	0.4	0.5	1.3	-0.6	-0.6	0.3	1.2	-0.7	0.7
Locomotion velocity, hab. session 1	0.4	0.6	0.9	-0.9	-0.9	0.9	0.9	-0.1	0.1
Time in familiar zone, hab. session 2	0.4	0.4	0.9	0.6	0.6	-0.2	-0.2	-0.9	0.9
Time in novel zone, hab. session 2	0.8	0.8	1.6	-0.4	-0.5	1.1	-0.0	1.2	-1.3
Total zone transitions, hab. session 2	1.7	2.1	4.1	-1.0	-1.1	-2.0	2.0	-1.1	1.2
Total locomotion distance, hab. session 2	1.1	1.5	2.8	-0.3	-0.4	-1.7	1.4	-1.4	1.4
Locomotion velocity, hab. session 2	1.0	1.3	3.0	-0.3	-0.4	-1.7	1.3	-1.2	1.2
Novel to familiar place preference ratio	0.4	0.4	1.6	0.4	0.2	1.3	-0.7	-0.3	0.3
Novelty place preference	0.3	0.3	1.7	0.3	0.1	1.3	-0.5	-0.2	0.1
Time in novel zone, NPP test	0.4	0.4	2.3	0.2	0.1	1.5	-0.5	-0.1	0.0
Total zone transitions, NPP test	0.5	0.8	1.7	-0.9	-1.1	-0.7	1.3	-0.4	0.4
Total locomotion distance, NPP test	0.3	0.5	0.8	-0.5	-0.7	0.0	0.9	-0.8	0.8
Locomotion velocity, NPP test	0.3	0.4	0.9	-0.1	-0.3	-0.2	0.7	-0.9	0.9
Intraocular pressure	0.9	1.3	2.8	0.9	0.9	0.6	-0.8	-1.7	1.7
Delta distance traveled before/after self-admin	1.2	1.3	3.1	-0.9	-0.8	0.2	0.4	1.8	-1.7
Delta ambulatory time before/after self-admin	1.1	1.4	4.1	-0.2	-0.2	0.4	-0.0	2.0	-2.0
Parametrial fat weight	0.6	1.5	4.5	-0.1	-0.1	2.1	-1.0	1.2	-1.3
Pavlov. Cond. lever latency	0.6	0.7	1.0	0.9	0.9	0.3	-0.8	-1.0	1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.5	-0.2	-0.2	0.1	0.7	-0.1	0.1
Pavlov. Cond. change in total contacts	0.6	0.7	1.6	-0.8	-0.8	-1.3	0.9	-0.5	0.5
Pavlov. Cond. index score	0.5	0.7	1.0	-1.0	-1.0	-0.2	0.9	0.8	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.7	-0.7	-0.1	0.7	0.7	-0.7
Pavlov. Cond. lever contacts	0.7	0.8	1.2	-1.1	-1.0	-0.4	1.0	0.9	-0.9
Pavlov. Cond. magazine entry number	0.3	0.3	1.1	0.6	0.6	0.4	-1.1	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.9	-0.6	-0.7	0.2	0.9	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.4	-1.2	-1.2	-0.5	1.1	0.8	-0.8
Pavlov. Cond. response bias	0.6	0.7	1.4	-1.1	-1.1	-0.4	1.2	0.4	-0.4
Pavlov. Cond. lever latency	1.6	2.2	5.8	1.3	1.2	2.4	-1.8	0.7	-0.7
Pavlov. Cond. magazine entry latency	1.7	2.1	3.6	-1.8	-1.9	-1.4	1.9	0.2	-0.1
Pavlov. Cond. change in total contacts	1.6	2.6	6.4	-1.2	-1.3	-2.5	1.6	-1.3	1.4
Pavlov. Cond. index score	1.8	2.5	6.0	-1.2	-1.3	-2.5	1.7	-1.1	1.2
Pavlov. Cond. latency score	1.7	2.3	5.8	-1.1	-1.2	-2.4	1.6	-1.1	1.2
Pavlov. Cond. lever contacts	1.8	2.5	6.1	-1.5	-1.3	-2.5	1.9	-0.6	0.7
Pavlov. Cond. magazine entry number	1.6	1.9	3.3	1.5	1.6	1.7	-1.8	0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.5	1.0	1.2	0.7	-0.3	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.2	5.6	-1.1	-1.2	-2.4	1.6	-1.1	1.2
Pavlov. Cond. response bias	2.7	3.7	6.6	-2.0	-2.0	-2.6	2.6	-0.5	0.6
Time in closed arm before self-admin	0.4	0.5	2.8	-0.4	-0.1	-1.7	0.4	-0.2	0.3
Time in closed arm after self-admin	0.7	0.8	2.0	1.1	1.0	0.4	-1.4	0.3	-0.3
Time in open arm before self-admin	0.5	0.6	1.1	1.0	0.8	0.6	-0.8	0.6	-0.6
Time in open arm after self-admin	0.4	0.4	0.7	-0.2	-0.2	-0.8	0.8	-0.6	0.7
Bone: periosteal estimation	1.9	4.0	7.5	-2.6	-2.7	0.5	2.0	1.7	-1.6
Bone: periosteal perimeter	1.7	2.9	5.0	-2.1	-2.2	0.6	1.7	1.5	-1.5
Bone: post-yield work	0.3	0.4	0.9	-0.8	-0.9	-0.1	0.4	0.6	-0.6
Progressive ratio test 1 active lever presses	0.2	0.3	0.8	0.6	0.5	0.9	0.2	0.3	-0.3
Progressive ratio test 1 breakpoint	0.2	0.3	0.9	0.7	0.5	0.9	0.1	0.3	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.8	0.3	0.1	0.9	0.1	0.4	-0.5
Progressive ratio test 2 active lever presses	1.6	1.9	3.8	1.8	1.7	1.9	-1.0	-0.3	0.2
Progressive ratio test 2 breakpoint	1.4	1.6	3.8	1.6	1.6	1.9	-0.9	-0.3	0.1
Progressive ratio test 2 inactive lever presses	2.9	4.7	9.0	2.6	2.4	3.0	-2.5	-0.1	-0.1
Incentive Sensitization - Responses	1.4	2.0	3.3	1.8	1.7	1.5	-1.8	-0.4	0.3
Incentive Sensitization - Breakpoint	1.6	2.1	3.4	1.8	1.8	1.6	-1.8	-0.5	0.4
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.2	0.1	-0.2	-0.5	0.5	-1.1	1.1
Progressive ratio	2.4	3.8	7.4	-2.7	-2.7	0.2	1.4	1.8	-1.8
Food seeking constrained by brief footshock	1.7	2.0	4.3	-2.1	-1.8	0.4	1.1	1.3	-1.3
Seeking ratio, punishment vs. effort	0.3	0.4	1.0	0.8	1.0	-0.2	-0.3	-0.5	0.5
Retroperitoneal fat weight	0.2	0.7	2.8	-0.2	-0.1	1.7	-0.3	0.7	-0.7
Reaction time number correct	0.8	1.5	3.2	1.0	1.0	-0.2	-0.6	-1.8	1.8
Reaction time mean minus median	0.1	0.2	0.4	-0.5	-0.6	0.6	0.1	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.3	-0.5	0.3	0.5	-0.2	0.2
Reaction time num false alarms	0.3	0.4	1.4	0.3	0.0	0.3	-1.2	-0.6	0.7
Reaction time num false alarms AUC	0.3	0.5	1.7	0.5	0.2	0.4	-1.3	-0.7	0.7
Reaction time trials correct on left	0.8	1.5	3.2	1.0	1.0	-0.2	-0.6	-1.8	1.8
Reaction time trials on left	0.8	1.6	3.4	1.1	1.1	-0.2	-0.6	-1.8	1.8
Reaction time mean	0.2	0.3	0.9	-0.3	-0.4	0.1	-0.2	-0.9	1.0
Reaction time mean AUC	0.2	0.3	0.8	-0.1	-0.1	0.2	-0.2	-0.9	0.9
Median of all reaction times	0.4	0.6	1.8	-0.0	-0.1	-0.1	-0.3	-1.3	1.3
Reaction time omissions	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.0	0.2	-0.2
Reaction time false alarm rate	0.2	0.2	1.1	0.3	-0.0	0.4	-1.0	0.1	-0.0
Reaction time premature initiation rate	3.1	4.3	8.3	-2.9	-2.8	-1.6	2.6	0.5	-0.4
Reaction time premature initiations	1.6	2.8	4.9	-2.2	-2.2	-1.6	2.1	-0.3	0.4
Std. dev. reaction times	0.1	0.1	0.2	-0.2	-0.2	0.5	-0.4	-0.4	0.4
Reaction time trials completed	0.8	1.6	3.4	1.1	1.1	-0.2	-0.6	-1.8	1.8
Reaction time trials AUC	1.0	1.8	3.7	1.2	1.2	-0.2	-0.8	-1.9	1.9
Run reversals in cocaine runway, females	3.0	3.0	7.0	1.7	2.3	1.6	-2.6	-0.2	0.1
Run reversals in cocaine runway, males	0.3	0.3	0.9	-0.5	-0.5	-0.9	0.8	-0.1	0.1
Latency to leave start box in cocaine runway	0.6	0.6	1.4	-1.0	-1.0	0.4	1.2	-0.4	0.4
Latency to leave start box in cocaine runway, F	0.3	0.4	1.8	0.0	-0.2	0.3	1.3	-0.5	0.4
Latency to leave start box in cocaine runway, M	0.9	0.9	1.9	-1.4	-1.3	1.2	-0.4	-0.0	0.0
Std. dev. time between licks in bursts	0.0	0.1	0.3	-0.0	-0.1	-0.5	0.2	0.2	-0.1
Total sessions with >9 infusions	0.5	0.7	3.2	0.3	0.3	1.8	0.0	0.4	-0.5
Short access day 1 total inactive lever presses	0.3	0.4	1.0	0.3	0.4	1.0	0.1	0.7	-0.8
Short access day 10 total inactive lever presses	0.2	0.5	1.3	-0.7	-0.7	-0.9	1.1	-0.1	0.1
Short access day 1 total infusions	0.7	0.9	1.9	1.1	1.3	1.4	-0.6	-0.2	0.1
Short access day 10 total infusions	1.4	1.8	5.4	1.7	1.6	2.3	-0.6	-0.0	-0.1
Short access total infusions	0.6	0.7	2.0	1.1	1.0	1.4	-0.1	-0.3	0.2
Short access day 1 locomotion	1.8	2.2	8.3	0.1	0.2	2.9	-0.6	1.5	-1.6
Short access day 10 total locomotion	0.4	0.7	1.7	1.3	0.9	0.1	-0.7	-0.7	0.7
Short access total locomotion	1.2	1.5	7.2	0.5	0.3	2.7	-0.5	0.6	-0.7
One hour access (0.3 mA shock)	0.4	0.5	0.8	0.8	0.7	0.8	-0.9	-0.2	0.2
Compulsive drug intake	1.1	1.3	2.9	-1.7	-1.4	-1.4	0.5	0.6	-0.5
One hour access (shock baseline)	1.5	2.3	4.8	2.2	2.0	1.6	-1.0	-1.0	0.9
Social response proportion	1.0	1.1	3.3	-1.2	-0.9	-0.1	1.8	0.7	-0.8
Social responses	2.4	3.0	7.3	-2.2	-2.1	-0.6	2.7	-0.9	0.9
Social time	0.4	0.6	1.5	-1.2	-0.8	0.6	1.0	0.4	-0.4
Soleus weight	0.4	1.1	2.2	-1.2	-1.0	-1.4	1.5	-0.3	0.3
Bone: stiffness	2.9	4.7	8.8	-2.8	-2.8	-0.8	3.0	1.2	-1.2
Tibialis anterior weight	1.5	5.2	9.5	-3.1	-2.9	-2.3	2.6	0.9	-0.8
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.2	0.4	0.5	0.7	-0.7	1.1	-1.1
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	-0.6	-0.4	0.4	0.9	-0.3	0.2
Time to tail flick, test, before self-admin	0.8	0.9	2.6	0.5	0.6	1.6	-0.9	0.7	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.0	-0.2	0.1	0.4	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	5.4	-1.8	-1.8	-0.3	2.3	-0.5	0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.5	-0.7	0.3	0.3	0.5	-0.5
Tibia length	0.1	0.4	0.7	-0.9	-0.7	0.3	0.8	0.5	-0.5
Ambulatory time before self-admin	0.9	1.4	3.6	-0.3	-0.1	-1.1	-0.1	-1.8	1.9
Ambulatory time after self-admin	0.2	0.3	0.5	-0.0	0.1	-0.7	-0.5	-0.6	0.7
Bone: tissue strength	0.2	0.2	0.3	0.4	0.4	-0.5	0.1	-0.5	0.5
Total heroin consumption	1.3	1.5	4.3	0.5	0.7	-0.3	0.0	-2.1	2.0
Bone: trabecular number	0.4	0.6	1.7	0.3	0.3	-0.4	0.4	-1.3	1.3
Bone: trabecular spacing	0.2	0.3	0.4	-0.6	-0.5	0.5	0.3	0.6	-0.6
Bone: trabecular thickness	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.2	-0.6	0.6
Bone: trabecular tissue density	3.0	4.4	8.2	-2.9	-2.9	-1.4	2.9	-0.3	0.3
Water consumed over 24 hours	0.1	0.2	0.8	0.3	0.4	0.9	-0.2	-0.2	0.2
Number of responses in last shaping day	0.8	0.8	2.3	-1.2	-1.5	0.5	1.0	0.2	-0.2