Zfp82

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	isoform ratio	XM_017601417.3	0.11	0.08	1.4e-03	0.06	0.04	0.05	0.06	3.9e-04	2.7e-03	8.4e-04	5.4e-04
2	Brain	gene expression	Zfp82	0.06	0.05	5.0e-06	0.06	0.05	0.05	0.05	2.3e-06	1.4e-05	1.4e-05	1.1e-05
3	Adipose	mRNA stability	Zfp82	0.04	0.04	2.1e-04	0.02	0.02	0.01	0.01	3.7e-03	2.4e-03	1.2e-02	6.9e-03
4	NAcc	intron excision ratio	chr1_94448004_94457437	0.07	0.05	9.9e-12	0.08	0.07	0.06	0.08	1.2e-11	5.3e-11	6.2e-10	7.4e-12
5	pVTA	intron excision ratio	chr1_94432405_94432736	0.03	0.02	9.7e-03	0.03	0.01	0.01	0.02	1.9e-03	3.3e-02	8.7e-02	6.5e-03
6	NAcc	intron excision ratio	chr1_94432939_94433764	0.01	0.01	7.0e-03	0.01	0.01	-0	0	4.2e-02	4.2e-02	6.1e-01	1.7e-01
7	pVTA	gene expression	Zfp82	0.03	0.02	4.3e-03	0.01	0.02	0	0.01	9.5e-02	1.8e-02	2.6e-01	6.7e-02
8	NAcc	isoform ratio	XM_017601417.3	0.01	0.01	8.7e-03	0	0.01	0	0	6.9e-02	2.8e-02	2.7e-01	1.9e-01
9	NAcc	intron excision ratio	chr1_94432405_94433764	0.03	0.03	3.6e-04	0.01	0.02	0.01	0.01	8.6e-03	1.7e-03	1.0e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.5	0.8	1.8	-0.0	0.0	-0.7	0.9	1.0	1.3	-0.8	-0.8	-1.4
Area under the delay curve	0.9	1.0	2.0	-1.4	-1.4	-1.0	0.8	0.7	1.2	-0.8	-0.9	-0.3
BMI with tail	0.1	0.3	0.9	0.7	0.9	0.5	-0.5	-0.4	-0.2	0.6	0.6	0.5
BMI without tail	0.3	1.0	1.6	-1.3	-1.1	-1.1	0.9	0.9	0.7	-1.0	-1.0	-0.7
Body weight	3.0	13.0	16.8	-3.3	-3.1	-3.6	3.7	3.7	4.1	-3.7	-3.6	-3.7
Weight adjusted by age	0.1	0.1	0.3	0.3	0.6	0.1	-0.1	0.4	0.5	0.0	0.1	-0.1
Bone surface	1.3	2.3	3.6	-0.9	-0.8	-1.5	1.6	1.6	1.9	-1.5	-1.5	-1.9
Bone volume	1.3	2.3	3.8	-0.9	-0.9	-1.5	1.6	1.6	2.0	-1.5	-1.5	-1.9
Breakpoint value in progressive ratio session	2.0	2.4	4.1	-2.0	-2.0	-1.6	1.7	1.1	1.1	-1.4	-1.5	-1.0
Number of licking bursts	2.9	4.8	5.5	2.2	2.0	2.2	-2.4	-2.1	-1.9	2.3	2.3	2.2
Context. condit. distance diff. score	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.1	-0.2	-0.2	0.1	0.1	0.1
Locomotion velocity, session 1	0.6	0.6	1.2	1.1	0.9	0.9	-0.6	-1.0	-0.6	0.7	0.7	0.4
Locomotion distance, session 1	0.5	0.6	0.7	-0.8	-0.8	-0.8	0.8	0.5	0.7	-0.8	-0.8	-0.8
Locomotion velocity, session 2	0.5	0.6	1.4	0.5	0.5	0.7	-0.8	-0.9	-1.2	0.7	0.7	0.9
Locomotion distance, session 2	1.5	2.0	2.4	1.6	1.4	1.3	-1.3	-1.5	-1.4	1.5	1.4	1.3
Locomotion velocity, session 3	0.3	0.4	0.5	0.6	0.7	0.6	-0.7	-0.6	-0.7	0.6	0.6	0.5
Locomotion distance, session 3	3.0	3.3	4.4	-2.1	-1.9	-2.1	1.8	1.9	1.3	-1.8	-1.9	-1.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.3	1.1	1.0	1.0	-0.7	-0.8	-0.6	0.8	0.8	0.5
Stereotopy head waving duration, day 3	1.4	1.7	2.5	1.6	1.6	1.5	-1.2	-1.3	-1.0	1.3	1.3	1.0
Locomotion velocity, session 7	0.2	0.3	0.4	-0.4	-0.2	-0.6	0.6	0.5	0.5	-0.5	-0.5	-0.6
Locomotion distance, session 7	0.1	0.2	0.3	-0.2	-0.2	-0.4	0.4	0.4	0.3	-0.5	-0.4	-0.6
Stereotopy head waving bouts, day 7	1.6	1.8	2.6	1.1	0.9	1.4	-1.4	-1.5	-1.2	1.4	1.5	1.6
Stereotopy head waving duration, day 7	2.2	2.6	3.2	1.4	1.2	1.7	-1.6	-1.8	-1.5	1.7	1.7	1.8
Locomotion velocity, session 8	4.2	5.0	5.6	2.2	2.4	2.1	-2.2	-2.3	-2.3	2.3	2.2	2.1
Locomotion distance, session 8	0.7	1.1	1.4	0.9	1.1	0.8	-1.1	-1.1	-1.2	1.1	1.0	1.1
Degree of sensitization distance	0.6	0.7	1.2	1.1	1.1	0.9	-0.8	-0.8	-0.5	0.7	0.7	0.3
Degree of sensitization stereotypy	1.2	1.3	2.3	0.7	0.6	1.1	-1.2	-1.3	-1.0	1.2	1.2	1.5
Conditioned locomotion	0.3	0.4	0.9	0.1	0.1	0.5	-0.5	-0.8	-0.8	0.6	0.6	1.0
Cocaine response after cond. corrected	0.1	0.1	0.1	-0.3	-0.4	0.2	-0.2	-0.1	-0.4	-0.0	0.0	0.3
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.3	-0.1	-0.1	-0.1
Cocaine response before conditioning	1.0	1.3	2.5	-0.4	-0.2	-1.1	1.2	1.3	1.3	-1.1	-1.1	-1.6
Saline control response	0.0	0.1	0.2	-0.2	0.1	0.2	-0.2	-0.3	-0.5	0.1	0.1	0.3
Bone: connectivity density	0.2	0.3	0.8	0.2	0.3	-0.4	0.6	0.7	0.7	-0.4	-0.5	-0.9
Bone: cortical apparent density	2.0	2.7	4.3	2.0	2.1	1.6	-1.5	-1.6	-1.4	1.6	1.6	1.2
Bone: cortical area	1.6	2.5	2.9	-1.7	-1.6	-1.6	1.4	1.6	1.4	-1.7	-1.7	-1.5
Bone: cortical porosity	1.1	1.2	1.9	1.4	1.4	1.0	-1.0	-0.8	-0.8	1.2	1.2	1.1
Bone: cortical porosity	1.7	1.9	2.5	1.6	1.6	1.2	-1.3	-1.1	-1.1	1.5	1.4	1.4
Bone: cortical thickness	0.6	1.0	1.4	-1.2	-1.1	-1.0	0.8	1.0	0.9	-1.1	-1.1	-0.9
Bone: cortical thickness	0.6	0.7	0.8	0.7	0.8	0.9	-0.8	-0.9	-0.9	0.8	0.8	0.8
Bone: cortical tissue density	2.3	3.1	4.8	2.2	2.2	1.7	-1.6	-1.7	-1.5	1.7	1.7	1.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.6	0.4	0.5	-0.4	-0.5	-0.4	0.5	0.5	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	0.2	0.4	-0.3	-0.3	-0.2	0.4	0.3	0.4
Condit. Reinf. active responses	2.1	2.6	3.4	1.7	1.4	1.6	-1.4	-1.9	-1.6	1.7	1.6	1.5
Condit. Reinf. inactive responses	2.3	2.8	4.0	1.7	1.5	1.5	-1.5	-2.0	-1.8	1.8	1.7	1.6
Incentive salience index mean	0.2	0.2	0.3	0.5	0.4	0.4	-0.4	-0.5	-0.5	0.5	0.4	0.5
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	-0.0	-0.1	0.1	-0.0	-0.3	0.1	0.0	0.1
Condit. Reinf. active minus inactive responses	1.8	2.3	4.0	-2.0	-1.9	-1.6	1.5	1.4	0.8	-1.5	-1.6	-1.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.7	-0.7	0.1	-0.3	-0.3	-0.6	-0.0	0.0	0.5
Condit. Reinf. active responses	3.8	5.3	6.4	-2.5	-2.4	-2.4	2.4	2.3	1.8	-2.4	-2.4	-2.0
Condit. Reinf. inactive responses	4.1	5.3	6.7	-2.0	-1.9	-2.5	2.5	2.6	2.1	-2.3	-2.4	-2.3
Condit. Reinf. lever presses	8.6	11.9	14.0	-3.7	-3.6	-3.5	3.5	3.4	3.1	-3.5	-3.5	-3.1
Condit. Reinf. lever reinforcers received	4.1	5.8	7.2	-2.7	-2.5	-2.6	2.5	2.4	1.9	-2.5	-2.5	-2.1
Conditioned reinforcement - actives	0.5	0.9	1.5	0.6	0.7	1.0	-1.2	-1.1	-0.8	0.9	0.9	1.0
Conditioned reinforcement - inactives	0.2	0.3	0.9	-0.9	-1.0	-0.6	0.4	0.4	-0.1	-0.3	-0.4	0.1
Conditioned locomotion	2.6	3.4	4.6	2.0	2.1	1.8	-1.7	-1.9	-1.8	1.9	1.8	1.6
Patch foraging indifference point 0 sec	0.1	0.1	0.4	-0.4	-0.3	-0.4	0.2	0.6	0.2	-0.4	-0.4	-0.3
Patch foraging indifference point AUC	0.7	1.0	1.1	0.9	1.0	1.0	-1.0	-0.8	-1.0	1.0	1.0	1.1
Delay disc. indifference point, 0s delay	0.6	0.6	1.6	-1.3	-1.3	-0.8	0.5	-0.2	0.7	-0.5	-0.6	-0.0
Delay disc. indifference point, 16s delay	1.8	2.0	4.8	-2.2	-2.1	-1.4	1.1	1.0	1.2	-1.1	-1.3	-0.4
Delay disc. indifference point, 2s delay	1.3	1.5	2.4	-1.6	-1.5	-1.2	1.2	0.8	1.4	-1.1	-1.1	-0.7
Delay disc. indifference point, 24s delay	2.3	2.6	3.0	-1.7	-1.6	-1.7	1.7	1.7	1.6	-1.5	-1.6	-1.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.6	-0.6	-0.2	-0.2	-0.1	0.4	-0.0	-0.1	0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.9	-0.2	-0.2	-0.4	0.3	0.5	0.9	-0.3	-0.4	-0.4
Indifference point function ln k	0.3	0.5	0.7	-0.7	-0.8	-0.7	0.8	0.5	0.6	-0.7	-0.8	-0.7
Indifference point function log k	0.3	0.5	0.7	-0.7	-0.8	-0.7	0.8	0.5	0.6	-0.7	-0.8	-0.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.6	-0.5	-0.4	-0.5	0.3	0.7	0.3	-0.5	-0.5	-0.4
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.3	-0.2	-0.1	-0.1	0.2
Patch foraging total patch changes 18 sec	0.2	0.3	0.9	0.7	0.9	0.4	-0.7	-0.1	-0.4	0.5	0.5	0.3
Patch foraging total patch changes 24 sec	0.4	0.7	0.9	-0.9	-0.8	-0.9	0.5	1.0	0.9	-0.8	-0.8	-0.6
Patch foraging total patch changes 6 sec	0.0	0.0	0.3	-0.0	0.1	-0.0	-0.1	0.6	-0.2	-0.0	-0.0	0.1
Patch foraging time to switch 0 sec	0.3	0.7	1.2	0.6	0.6	0.8	-1.1	-0.8	-0.9	0.8	0.7	0.9
Patch foraging water rate 0 sec	0.5	1.0	1.6	1.1	1.3	1.0	-0.7	-0.8	-1.1	1.0	1.1	0.9
Patch foraging water rate 12 sec	0.4	0.8	1.5	-1.0	-1.1	-0.8	1.0	0.8	1.2	-0.9	-0.7	-0.6
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.2	0.1	0.4	-0.0	-0.4	-0.1	0.3	0.4	0.4
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.3	-0.7	-0.1	0.2	-0.1	0.2	0.1	0.1	0.4
Patch foraging water rate 6 sec	0.8	1.1	1.9	-0.7	-0.7	-1.1	1.3	1.2	1.4	-1.0	-0.9	-1.1
Seeking ratio, delayed vs. immediate footshock	1.2	1.5	2.2	-1.5	-1.5	-1.4	0.7	1.0	1.4	-1.2	-1.2	-0.9
Distance traveled before self-admin	0.6	0.8	2.2	-1.5	-1.5	-0.8	0.8	-0.2	0.2	-0.7	-0.8	-0.2
Distance traveled after self-admin	2.5	3.0	4.3	-1.7	-1.7	-1.7	2.1	1.7	1.6	-1.7	-1.7	-1.8
Extensor digitorum longus weight	0.2	0.7	1.0	0.8	0.9	1.0	-0.9	-0.8	-0.5	0.8	0.8	0.6
Bone: elastic displacement	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.1
Bone: elastic work	1.9	2.5	3.2	-1.6	-1.5	-1.6	1.5	1.6	1.8	-1.6	-1.6	-1.5
Bone: endosteal estimation	1.6	3.5	3.9	-1.7	-1.7	-1.9	2.0	1.9	1.8	-1.9	-1.9	-1.9
Bone: endosteal perimeter	1.4	3.1	3.9	-1.9	-2.0	-1.9	1.8	1.6	1.4	-1.8	-1.8	-1.6
Epididymis fat weight	0.1	0.2	0.6	0.7	0.8	0.2	-0.2	-0.0	0.5	0.2	0.2	-0.2
Delta time in closed arm before/after self-admin	1.0	0.9	1.4	-0.6	-0.6	-0.9	1.1	1.1	1.2	-1.0	-0.9	-1.1
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.5	0.5	0.8	-0.7	-0.4	-0.6	0.7	0.8	0.8
Diff in mean of infusions in LGA sessions	0.3	0.3	1.1	-0.2	-0.2	0.3	-0.3	-0.8	-1.1	0.5	0.4	0.9
Delay discount exponential model param	1.0	1.1	1.9	1.4	1.3	1.1	-0.9	-0.8	-1.3	0.9	0.9	0.4
Extinction: sum of active levers before priming	3.4	3.7	6.1	-1.2	-1.2	-1.9	2.2	1.9	2.0	-2.0	-2.0	-2.5
Active lever presses in extinction session 6	1.8	1.8	2.7	-1.1	-1.1	-1.2	1.7	1.2	1.1	-1.4	-1.5	-1.6
Bone: final force	1.8	2.8	3.5	-1.4	-1.3	-1.7	1.6	1.8	1.9	-1.7	-1.7	-1.8
Bone: final moment	2.3	3.8	4.4	-1.7	-1.6	-2.0	1.9	2.1	2.1	-2.0	-2.0	-2.1
Food consumed during 24 hour testing period	0.6	0.8	1.1	-0.9	-0.8	-1.0	0.9	1.0	0.8	-0.8	-0.9	-0.8
Glucose	0.2	0.4	0.6	0.7	0.6	0.8	-0.6	-0.7	-0.3	0.5	0.6	0.4
Heart weight	0.2	0.3	0.8	-0.9	-0.9	-0.4	0.5	0.4	0.3	-0.4	-0.3	0.1
Delay discount hyperbolic model param	0.7	0.8	1.6	1.3	1.2	0.9	-0.7	-0.7	-1.2	0.7	0.8	0.3
Intermittent access intake day 1-15 change	1.1	2.3	3.6	-1.3	-1.2	-1.4	1.6	1.6	1.9	-1.5	-1.4	-1.6
Intermittent access intake escalation	0.8	1.6	3.0	-0.9	-0.8	-1.1	1.3	1.3	1.7	-1.3	-1.1	-1.4
Intermittent access intake escalation 2	1.4	1.6	2.0	-1.4	-1.4	-1.2	1.1	1.2	1.2	-1.4	-1.3	-1.2
Intermitt. access day 1 inactive lever presses	1.5	5.7	7.3	-2.2	-2.3	-2.7	2.5	2.7	2.0	-2.4	-2.5	-2.3
Intermitt. access day 15 inactive lever presses	0.6	1.2	1.8	-1.0	-1.2	-1.3	1.1	1.3	0.8	-1.0	-1.0	-0.8
Intermitt. access escalation Index	0.1	0.1	0.3	-0.2	-0.3	0.2	-0.3	-0.5	-0.1	0.3	0.3	0.6
Intermittent access day 1 total infusions	1.4	2.3	3.6	1.0	0.9	1.4	-1.7	-1.9	-1.5	1.6	1.5	1.8
Intermittent access day 15 total infusions	0.0	0.1	0.2	-0.3	-0.3	0.0	-0.2	-0.4	0.3	0.1	0.1	0.3
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.8	-0.5	-0.6	0.2	-0.6	-0.7	-0.4	0.4	0.3	0.9
Intermittent access total infusions	0.4	0.5	1.0	0.2	0.1	0.6	-0.8	-1.0	-0.5	0.7	0.7	1.0
Intermittent access day 1 locomotion	0.7	0.9	1.6	0.5	0.5	0.6	-0.9	-1.2	-1.2	1.0	0.9	1.3
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.2	0.4	-0.1	0.1	-0.2	-0.1	0.1	0.1	0.1
Intermittent access total locomotion	1.1	1.3	1.7	1.0	1.1	0.9	-1.0	-1.3	-1.3	1.2	1.1	1.2
Intermittent access standard deviation	2.4	4.9	5.7	-2.3	-2.3	-2.4	2.2	2.1	2.0	-2.2	-2.3	-2.0
Left kidney weight	1.8	8.5	13.5	-2.3	-2.1	-2.7	2.8	3.3	3.7	-3.0	-2.8	-3.2
Right kidney weight	2.4	11.1	16.6	-2.8	-2.6	-3.1	3.2	3.5	4.1	-3.4	-3.3	-3.7
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1	0.1	0.0	-0.1	-0.1	-0.0
Post-drug Anxiety	0.1	0.1	0.3	-0.5	-0.5	-0.1	-0.1	-0.1	-0.2	-0.0	-0.1	0.4
Baseline Anxiety	0.0	0.0	0.1	-0.3	-0.3	-0.3	0.0	0.3	0.1	-0.1	-0.1	0.1
Tail length	5.3	20.8	22.7	-4.8	-4.8	-4.6	4.5	4.5	4.4	-4.7	-4.6	-4.3
Length with tail	7.4	32.1	34.7	-5.7	-5.7	-5.6	5.7	5.6	5.9	-5.8	-5.6	-5.4
Length without tail	3.1	9.9	13.2	-2.8	-2.8	-3.0	3.3	3.3	3.6	-3.2	-3.0	-3.2
Times rat made contact with spout	0.9	1.0	1.8	1.3	1.3	1.2	-1.1	-1.0	-0.4	0.9	1.0	0.5
Lifetime Intake	0.7	0.8	1.4	0.6	0.5	0.8	-1.1	-1.2	-0.8	0.9	0.9	1.1
Liver weight, left	0.5	0.8	1.0	0.6	0.5	1.0	-1.0	-0.9	-0.9	0.9	0.9	1.0
Liver weight, right	0.2	0.4	0.8	0.1	0.1	0.7	-0.6	-0.6	-0.9	0.6	0.6	0.8
Locomotor activity	0.6	0.9	2.1	1.2	1.4	1.0	-0.6	-0.8	-0.8	0.8	0.8	0.4
Locomotor testing distance	0.8	1.5	3.2	1.6	1.8	1.3	-1.0	-1.1	-0.9	1.1	1.1	0.6
Locomotor testing rearing	1.8	3.6	4.4	1.8	2.1	2.0	-2.0	-1.9	-1.6	1.8	2.0	1.7
Locomotion in novel chamber	0.1	0.1	0.6	0.3	0.1	0.2	0.1	-0.5	-0.8	0.3	0.1	0.1
Locomotion in novel chamber post-restriction	0.2	0.4	1.2	-1.1	-1.1	-0.5	0.3	-0.3	-0.2	-0.4	-0.6	0.1
Fecal boli incidents, locomotor time 1	1.9	2.7	5.2	1.4	1.4	1.6	-1.3	-1.8	-2.3	1.7	1.5	1.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	0.3	-0.0	-0.1	-0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	0.0	-0.3	0.1	0.1	0.2
Bouts of movement, locomotor time 1	1.4	1.6	4.3	-2.0	-2.1	-1.3	1.0	0.6	0.5	-1.1	-1.1	-0.4
Total resting periods, locomotor time 1	1.3	1.5	4.2	-2.0	-2.0	-1.3	0.9	0.5	0.4	-1.0	-1.1	-0.3
Rest time, locomotor task time 1	1.0	1.2	2.9	0.4	0.3	0.9	-0.7	-1.7	-1.5	1.1	0.9	1.5
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.3	0.4	0.1	-0.3	0.3	0.2	0.0	0.1	-0.1
Vertical activity count, locomotor time 1	0.7	1.7	3.4	-0.8	-0.7	-1.3	1.2	1.8	1.5	-1.3	-1.2	-1.5
Time >=10cm from walls, locomotor time 2	0.8	1.2	2.8	0.1	0.2	1.0	-1.2	-1.2	-1.7	1.1	1.0	1.5
Bouts of movement, locomotor time 2	0.1	0.2	0.9	-0.9	-0.9	-0.2	0.0	-0.1	0.3	-0.2	-0.2	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.4	-0.7	-0.6	-0.0	-0.1	-0.2	0.0	-0.0	-0.0	0.4
Rest time, locomotor task time 2	0.2	0.2	0.6	0.1	-0.0	0.4	-0.2	-0.7	-0.7	0.4	0.4	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.5	0.6	0.5	-0.7	-0.2	0.0	0.4	0.5	0.4
Vertical activity count, locomotor time 2	0.5	0.7	1.1	-0.8	-0.6	-0.9	0.7	1.0	1.0	-0.8	-0.8	-0.8
Light reinforcement 1	0.1	0.2	0.4	0.5	0.6	0.4	-0.6	-0.3	-0.3	0.5	0.5	0.5
Light reinforcement 2	2.5	3.8	4.9	2.2	2.2	2.0	-1.7	-1.9	-1.9	2.0	2.0	1.7
Bone: marrow area	1.7	3.6	4.1	-1.7	-1.8	-1.9	2.0	1.9	1.8	-2.0	-2.0	-2.0
Bone: maximum diameter	1.4	2.7	3.0	-1.7	-1.6	-1.7	1.6	1.7	1.5	-1.7	-1.7	-1.5
Bone: maximum force	3.0	5.2	6.2	-2.1	-2.1	-2.3	2.2	2.4	2.5	-2.3	-2.3	-2.3
Bone: maximum moment	3.6	6.2	6.8	-2.4	-2.3	-2.5	2.4	2.6	2.6	-2.6	-2.6	-2.5
Mean time between licks in bursts	0.0	0.0	0.1	-0.3	-0.3	-0.3	0.1	0.3	0.0	-0.1	-0.2	0.1
Mean num. licks in bursts	1.1	1.7	2.6	-1.1	-0.9	-1.2	1.4	1.2	1.4	-1.4	-1.4	-1.6
Cd content in liver	0.2	0.2	0.5	0.7	0.7	0.5	-0.3	-0.5	-0.1	0.5	0.5	0.3
Co content in liver	0.5	0.6	1.1	1.0	1.1	0.8	-0.7	-0.6	-0.8	0.7	0.7	0.6
Cu content in liver	1.2	1.4	1.7	-1.1	-1.2	-1.1	1.2	1.2	1.3	-1.2	-1.1	-1.1
Fe content in liver	0.3	0.4	0.4	0.7	0.6	0.6	-0.5	-0.6	-0.6	0.6	0.6	0.6
K content in liver	0.1	0.1	0.3	-0.5	-0.4	-0.3	0.3	0.5	0.0	-0.3	-0.3	-0.0
Mg content in liver	0.3	0.3	0.7	0.2	0.3	0.6	-0.5	-0.3	-0.8	0.5	0.5	0.8
Mn content in liver	0.4	0.5	0.9	0.7	0.8	0.8	-0.6	-0.5	-0.9	0.7	0.7	0.6
Na content in liver	0.9	1.0	1.6	-1.2	-1.1	-1.0	0.8	1.0	0.8	-1.0	-1.0	-0.8
Rb content in liver	0.1	0.1	0.3	0.1	-0.0	0.2	-0.2	-0.2	-0.3	0.3	0.3	0.5
Se content in liver	5.7	6.7	7.5	2.7	2.7	2.7	-2.5	-2.4	-2.7	2.6	2.6	2.4
Sr content in liver	0.2	0.2	0.3	0.6	0.6	0.5	-0.4	-0.3	-0.5	0.4	0.4	0.3
Zn content in liver	2.7	3.0	4.3	2.1	2.0	1.8	-1.6	-1.3	-1.5	1.8	1.8	1.5
Bone: minimum diameter	3.8	7.0	9.2	-3.0	-3.0	-2.8	2.5	2.5	2.2	-2.7	-2.7	-2.2
Time in familiar zone, hab. session 1	0.4	0.3	0.6	-0.5	-0.6	-0.5	0.5	0.5	0.5	-0.7	-0.6	-0.8
Time in novel zone, hab. session 1	1.1	1.1	2.4	0.6	0.6	0.9	-1.1	-0.9	-1.0	1.2	1.1	1.5
Total zone transitions, hab. session 1	0.0	0.0	0.2	-0.2	-0.3	-0.1	-0.0	-0.4	-0.1	0.0	0.0	0.2
Total locomotion distance, hab. session 1	1.6	2.3	4.1	-1.9	-2.0	-1.5	1.5	1.1	1.2	-1.4	-1.5	-1.0
Locomotion velocity, hab. session 1	0.9	1.3	1.9	-1.3	-1.4	-1.2	1.2	0.9	0.9	-1.1	-1.2	-0.9
Time in familiar zone, hab. session 2	2.3	2.5	3.0	-1.6	-1.7	-1.6	1.7	1.7	1.1	-1.6	-1.6	-1.4
Time in novel zone, hab. session 2	1.4	1.5	1.8	1.2	1.2	1.3	-1.3	-1.3	-0.8	1.2	1.3	1.1
Total zone transitions, hab. session 2	2.9	3.7	4.9	1.5	1.4	1.9	-2.0	-2.2	-2.0	2.0	2.0	2.2
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.2	-0.3	0.1	-0.1	-0.4	-0.2	0.3	0.2	0.6
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.1	0.0	0.3	-0.3	-0.5	-0.4	0.4	0.4	0.6
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.6	-0.7	-0.4	0.3	0.6	0.5	-0.4	-0.4	-0.2
Novelty place preference	0.1	0.1	0.4	-0.5	-0.6	-0.3	0.1	0.5	0.3	-0.3	-0.2	-0.1
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	-0.4	-0.1	-0.1	0.2	0.1	-0.1	-0.0	0.2
Total zone transitions, NPP test	0.1	0.1	0.3	0.5	0.4	0.3	-0.1	-0.6	-0.3	0.3	0.3	0.0
Total locomotion distance, NPP test	2.7	3.7	4.2	-1.9	-1.9	-1.9	2.1	1.7	1.9	-2.0	-2.0	-1.9
Locomotion velocity, NPP test	2.9	4.1	4.8	-2.1	-2.0	-2.0	2.2	1.8	2.0	-2.1	-2.1	-2.0
Intraocular pressure	0.0	0.1	0.3	-0.1	-0.2	0.0	-0.1	-0.4	-0.5	0.1	0.0	0.1
Delta distance traveled before/after self-admin	1.6	1.7	3.7	-0.5	-0.5	-1.2	1.3	1.9	1.5	-1.3	-1.1	-1.7
Delta ambulatory time before/after self-admin	1.4	1.8	3.5	-0.4	-0.4	-1.1	1.5	1.9	1.7	-1.2	-1.1	-1.7
Parametrial fat weight	0.2	0.4	0.8	0.9	0.9	0.8	-0.4	-0.1	-0.6	0.5	0.6	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.2	0.2	0.6	-0.3	-0.2	-0.3
Pavlov. Cond. magazine entry latency	0.6	0.7	1.1	0.6	0.4	0.9	-1.0	-1.0	-0.8	0.9	0.9	1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.7	0.3	0.2	0.5	-0.6	-0.6	-0.8	0.6	0.6	0.9
Pavlov. Cond. index score	0.5	0.6	0.8	0.6	0.5	0.8	-0.8	-0.8	-0.8	0.8	0.8	0.9
Pavlov. Cond. latency score	0.2	0.3	0.5	0.4	0.3	0.5	-0.5	-0.5	-0.7	0.5	0.5	0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.1	0.2	-0.4	-0.2	-0.2	0.1
Pavlov. Cond. magazine entry number	0.4	0.6	0.9	-0.5	-0.3	-0.8	0.9	0.9	0.7	-0.8	-0.8	-1.0
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.7	0.9	1.0	0.9	-0.8	-1.1	-1.3	0.9	0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.3	0.7	0.6	1.0	-1.0	-1.0	-1.0	1.0	1.0	1.1
Pavlov. Cond. response bias	0.2	0.3	0.4	0.3	0.2	0.6	-0.6	-0.6	-0.6	0.5	0.5	0.7
Pavlov. Cond. lever latency	5.4	7.4	7.8	2.7	2.7	2.8	-2.8	-2.8	-2.7	2.7	2.7	2.5
Pavlov. Cond. magazine entry latency	3.9	4.7	5.3	-2.2	-2.2	-2.2	2.3	2.2	2.1	-2.2	-2.2	-2.0
Pavlov. Cond. change in total contacts	7.8	12.5	13.4	-3.7	-3.6	-3.7	3.5	3.5	3.5	-3.6	-3.6	-3.2
Pavlov. Cond. index score	6.3	8.4	8.8	-2.9	-2.9	-3.0	3.0	2.9	3.0	-2.9	-2.9	-2.7
Pavlov. Cond. latency score	5.6	7.4	7.9	-2.7	-2.7	-2.8	2.8	2.7	2.7	-2.7	-2.8	-2.5
Pavlov. Cond. lever contacts	5.9	8.1	8.6	-2.9	-2.9	-2.9	2.9	2.8	2.9	-2.9	-2.9	-2.6
Pavlov. Cond. magazine entry number	4.4	5.5	6.7	2.2	2.3	2.3	-2.4	-2.2	-2.6	2.4	2.3	2.3
Pavlov. Cond. intertrial magazine entries	1.5	2.2	3.7	1.9	1.9	1.4	-1.4	-1.1	-1.4	1.4	1.4	1.0
Pavlov. Cond. lever-magazine prob. diff.	6.0	7.9	8.5	-2.8	-2.8	-2.9	2.8	2.8	2.9	-2.8	-2.8	-2.6
Pavlov. Cond. response bias	6.9	9.3	10.0	-3.1	-3.1	-3.1	3.1	3.0	3.2	-3.1	-3.1	-2.8
Time in closed arm before self-admin	1.3	1.7	3.4	0.3	0.3	1.2	-1.8	-1.5	-1.3	1.3	1.3	1.8
Time in closed arm after self-admin	0.5	0.5	1.7	-1.3	-1.3	-0.7	0.2	-0.0	0.2	-0.4	-0.6	0.1
Time in open arm before self-admin	3.9	4.2	7.1	-1.0	-1.0	-2.0	2.5	2.4	2.0	-2.1	-2.1	-2.7
Time in open arm after self-admin	0.7	0.7	1.8	-0.0	-0.0	-0.6	1.1	1.3	1.0	-0.8	-0.6	-1.1
Bone: periosteal estimation	2.4	5.0	5.4	-2.2	-2.2	-2.3	2.2	2.3	2.1	-2.3	-2.3	-2.2
Bone: periosteal perimeter	1.7	3.0	4.5	-2.1	-2.1	-1.8	1.6	1.5	1.2	-1.8	-1.8	-1.4
Bone: post-yield work	2.2	3.2	3.8	-1.7	-1.7	-1.9	1.8	1.8	1.8	-1.8	-1.8	-1.7
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.0	-0.2	0.1	0.1	-0.0	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	-0.1	0.1	-0.0	-0.1	-0.0
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.8	-0.8	-0.9	-0.7	0.4	0.3	0.0	-0.3	-0.4	-0.0
Progressive ratio test 2 active lever presses	0.2	0.3	0.7	0.3	0.3	0.5	-0.7	-0.9	-0.3	0.5	0.5	0.5
Progressive ratio test 2 breakpoint	0.4	0.4	1.0	0.4	0.5	0.6	-0.9	-1.0	-0.5	0.6	0.6	0.6
Progressive ratio test 2 inactive lever presses	0.5	0.8	2.3	-1.4	-1.5	-1.1	0.6	0.3	0.0	-0.7	-0.9	-0.2
Incentive Sensitization - Responses	0.5	0.7	1.3	0.6	0.6	0.8	-1.0	-1.1	-0.8	0.8	0.8	0.8
Incentive Sensitization - Breakpoint	0.5	0.6	1.2	0.6	0.6	0.8	-1.0	-1.1	-0.8	0.8	0.8	0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.5	0.5	0.2	-0.1	-0.4	-0.4	0.2	0.2	-0.0
Progressive ratio	0.0	0.0	0.1	0.1	0.2	-0.1	0.1	0.0	-0.3	0.1	-0.1	0.1
Food seeking constrained by brief footshock	2.9	3.6	4.5	-1.9	-2.0	-2.0	2.1	1.7	1.5	-1.9	-2.0	-1.8
Seeking ratio, punishment vs. effort	0.5	0.7	1.5	-1.1	-1.2	-0.8	0.8	0.7	0.8	-0.8	-0.8	-0.6
Retroperitoneal fat weight	0.6	2.4	4.0	1.9	2.0	1.9	-1.4	-1.2	-1.4	1.4	1.5	0.9
Reaction time number correct	0.0	0.1	0.3	0.5	0.4	0.3	0.2	-0.1	0.0	0.2	0.3	-0.1
Reaction time mean minus median	0.1	0.4	0.8	-0.3	-0.2	-0.5	0.6	0.9	0.8	-0.6	-0.5	-0.8
Reaction time mean minus median AUC	0.3	0.8	1.8	-0.3	-0.2	-0.7	0.8	1.4	1.3	-0.8	-0.7	-1.2
Reaction time num false alarms	1.1	1.5	2.1	1.4	1.4	1.3	-1.3	-1.1	-0.9	1.2	1.3	1.0
Reaction time num false alarms AUC	1.3	2.0	3.2	1.8	1.7	1.4	-1.4	-1.2	-1.1	1.4	1.5	1.1
Reaction time trials correct on left	0.0	0.1	0.3	0.5	0.4	0.3	0.2	-0.1	0.0	0.2	0.3	-0.1
Reaction time trials on left	0.0	0.1	0.3	0.5	0.4	0.3	0.2	-0.1	0.0	0.2	0.3	-0.1
Reaction time mean	0.1	0.2	0.5	0.6	0.6	-0.1	0.2	0.4	0.7	-0.1	-0.0	-0.6
Reaction time mean AUC	0.2	0.2	0.7	0.8	0.8	0.1	0.1	0.4	0.6	0.0	0.1	-0.6
Median of all reaction times	0.2	0.2	0.9	0.9	0.9	0.3	-0.2	-0.1	0.3	0.3	0.3	-0.2
Reaction time omissions	0.1	0.2	0.7	0.7	0.8	0.4	-0.3	0.1	0.2	0.2	0.4	-0.1
Reaction time false alarm rate	0.7	1.0	1.3	1.1	1.1	0.9	-1.2	-0.9	-0.9	1.0	1.0	0.9
Reaction time premature initiation rate	0.1	0.1	0.3	-0.5	-0.5	-0.3	0.3	0.1	0.2	-0.1	-0.2	0.1
Reaction time premature initiations	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.4	0.0	0.1	0.0	0.1	0.1
Std. dev. reaction times	0.3	0.5	1.5	-0.0	-0.0	-0.6	0.6	1.0	1.2	-0.6	-0.5	-1.0
Reaction time trials completed	0.0	0.1	0.3	0.5	0.4	0.3	0.2	-0.1	0.0	0.2	0.3	-0.1
Reaction time trials AUC	0.1	0.2	0.6	0.7	0.7	0.5	0.0	-0.2	-0.1	0.3	0.5	-0.1
Run reversals in cocaine runway, females	0.5	0.5	1.3	-0.0	-0.0	-0.6	0.9	0.8	1.1	-0.6	-0.5	-0.9
Run reversals in cocaine runway, males	0.4	0.4	1.4	1.2	1.2	0.7	-0.4	0.2	-0.1	0.4	0.4	-0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.4	0.1	0.1	-0.3	0.5	0.4	0.6	-0.2	-0.1	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.6	0.6	0.2	0.1	0.3	0.2	0.2	0.3	0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.2	-0.0	0.4	-0.3	-0.2	-0.1
Std. dev. time between licks in bursts	0.4	0.6	1.5	-1.2	-1.2	-0.9	0.6	0.8	0.0	-0.6	-0.6	0.1
Total sessions with >9 infusions	1.6	2.0	2.9	1.7	1.7	1.5	-1.4	-1.3	-1.1	1.4	1.4	0.9
Short access day 1 total inactive lever presses	0.7	0.9	2.0	-1.3	-1.4	-1.1	1.1	0.5	0.6	-0.7	-0.8	-0.3
Short access day 10 total inactive lever presses	1.9	4.5	7.3	-2.7	-2.7	-2.4	2.1	1.8	1.2	-2.1	-2.2	-1.5
Short access day 1 total infusions	0.1	0.1	0.3	-0.4	-0.3	0.0	-0.3	-0.1	-0.5	0.1	0.1	0.4
Short access day 10 total infusions	0.5	0.6	0.9	0.9	0.8	0.8	-0.9	-0.9	-0.5	0.8	0.8	0.5
Short access total infusions	0.9	1.1	1.5	1.0	0.9	1.1	-1.2	-1.1	-1.0	1.1	1.1	0.9
Short access day 1 locomotion	1.7	2.1	4.1	2.0	2.0	1.4	-1.3	-1.0	-1.2	1.4	1.4	0.9
Short access day 10 total locomotion	0.2	0.4	0.8	-0.3	-0.3	-0.9	0.8	0.7	0.3	-0.5	-0.7	-0.7
Short access total locomotion	1.4	1.6	2.1	1.4	1.5	1.1	-1.3	-1.2	-1.3	1.3	1.2	1.1
One hour access (0.3 mA shock)	0.6	0.7	1.3	-1.1	-1.2	-1.0	0.6	0.5	0.9	-0.7	-0.8	-0.5
Compulsive drug intake	0.3	0.4	1.7	-1.2	-1.3	-0.4	0.1	0.1	-0.0	-0.3	-0.2	0.5
One hour access (shock baseline)	0.0	0.0	0.1	-0.2	-0.3	-0.1	-0.0	-0.2	0.4	-0.0	-0.1	0.0
Social response proportion	2.6	3.0	4.3	-2.0	-2.1	-1.9	1.9	1.5	1.1	-1.7	-1.8	-1.3
Social responses	0.7	0.9	2.3	-0.8	-0.7	-1.1	1.5	1.1	0.2	-0.9	-1.0	-0.9
Social time	2.4	3.3	4.2	-1.5	-1.6	-2.0	2.0	1.8	1.7	-1.8	-1.9	-1.9
Soleus weight	0.1	0.2	0.7	0.6	0.8	0.4	-0.3	-0.3	-0.2	0.4	0.4	0.2
Bone: stiffness	1.6	2.6	3.0	-1.6	-1.6	-1.6	1.5	1.6	1.7	-1.6	-1.6	-1.5
Tibialis anterior weight	0.1	0.2	0.4	0.4	0.6	0.6	-0.5	-0.4	-0.2	0.3	0.4	0.2
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.0	1.0	1.0	0.7	-0.6	-0.4	-0.4	0.7	0.7	0.5
Time to tail flick, vehicle, after self-admin	0.9	1.2	2.9	-1.7	-1.7	-1.1	1.2	0.5	0.4	-0.9	-1.1	-0.4
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.7	0.7	0.3	-0.5	-0.4	0.5	0.4	0.5	0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.2	0.2	0.2	-0.2	-0.3	-0.4	0.2	0.2	0.3
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	1.6	-1.2	-1.2	-1.1	1.3	0.9	0.9	-1.0	-1.1	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	1.6	-0.1	-0.1	0.4	-0.2	-0.3	-1.2	0.3	0.2	0.5
Tibia length	2.4	6.5	10.4	-2.0	-1.9	-2.5	2.6	2.6	3.2	-2.6	-2.5	-2.8
Ambulatory time before self-admin	0.6	0.9	2.5	-1.6	-1.6	-0.9	0.8	0.0	0.1	-0.7	-0.9	-0.2
Ambulatory time after self-admin	4.6	5.4	7.6	-2.1	-2.1	-2.4	2.8	2.3	2.2	-2.3	-2.3	-2.4
Bone: tissue strength	3.3	3.3	3.9	-1.9	-1.9	-1.9	1.6	2.0	1.9	-1.8	-1.8	-1.5
Total heroin consumption	0.4	0.5	0.7	-0.6	-0.6	-0.8	0.8	0.5	0.8	-0.6	-0.7	-0.5
Bone: trabecular number	1.1	1.8	3.3	-0.6	-0.5	-1.3	1.4	1.5	1.8	-1.3	-1.3	-1.7
Bone: trabecular spacing	0.6	0.8	2.1	-1.3	-1.4	-0.7	0.7	0.7	0.4	-0.8	-0.8	-0.4
Bone: trabecular thickness	0.2	0.3	0.7	0.8	0.8	0.5	-0.5	-0.3	0.1	0.4	0.5	0.1
Bone: trabecular tissue density	1.8	2.6	3.5	1.8	1.7	1.9	-1.7	-1.8	-1.4	1.5	1.6	1.2
Water consumed over 24 hours	0.3	0.4	0.8	-0.2	-0.1	-0.6	0.7	0.7	0.8	-0.7	-0.7	-0.9
Number of responses in last shaping day	0.2	0.3	0.8	-0.9	-0.9	-0.5	0.2	0.0	0.2	-0.4	-0.4	-0.1