Hub : Genes

Zfp551

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Zfp551	0.3	0.18	1.1e-03	0.03	0.04	0.03	0.02	6.2e-04	2.1e-04	1.8e-03	2.8e-03
2	PL	gene expression	Zfp551	0.07	0.06	1.9e-03	0.02	0.02	0.02	0.02	9.9e-04	1.0e-03	4.4e-03	2.0e-03
3	pVTA	gene expression	Zfp551	0.29	0.17	3.6e-04	0.07	0.07	0.05	0.06	3.8e-04	4.8e-04	3.0e-03	8.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.3	-0.6	0.4	0.2
Area under the delay curve	0.5	0.6	1.0	-1.0	-0.7	0.5
BMI with tail	0.3	1.1	3.3	-0.0	-1.8	0.1
BMI without tail	0.3	0.6	1.5	-1.2	-0.3	0.3
Body weight	0.6	2.6	5.1	1.5	0.6	-2.3
Weight adjusted by age	0.7	0.8	2.0	-0.8	1.4	-0.0
Bone surface	1.4	2.4	6.0	0.4	2.4	-1.1
Bone volume	1.1	1.8	4.3	0.5	2.1	-1.0
Breakpoint value in progressive ratio session	0.9	1.0	1.3	-1.0	-1.1	0.9
Number of licking bursts	0.0	0.0	0.1	0.3	0.1	0.1
Context. condit. distance diff. score	0.5	0.6	1.1	-1.1	-0.2	0.7
Locomotion velocity, session 1	3.7	4.0	6.9	-2.1	0.9	2.6
Locomotion distance, session 1	2.4	3.1	5.8	-1.5	2.4	1.1
Locomotion velocity, session 2	1.2	1.4	2.6	-1.1	0.5	1.6
Locomotion distance, session 2	1.0	1.4	3.8	-0.5	2.0	0.5
Locomotion velocity, session 3	0.1	0.1	0.4	-0.2	-0.0	0.6
Locomotion distance, session 3	0.8	0.8	1.4	-1.2	0.7	0.8
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.6	-0.4	-0.3
Stereotopy head waving duration, day 3	0.3	0.3	0.7	0.8	-0.2	-0.5
Locomotion velocity, session 7	0.3	0.3	0.4	-0.4	0.6	0.6
Locomotion distance, session 7	0.6	0.8	1.1	-1.0	0.4	1.0
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	0.9	0.3	-0.7
Stereotopy head waving duration, day 7	0.4	0.4	0.7	0.8	0.4	-0.7
Locomotion velocity, session 8	1.1	1.3	2.0	-1.3	0.5	1.4
Locomotion distance, session 8	0.8	1.1	1.7	-1.3	0.8	1.0
Degree of sensitization distance	0.0	0.0	0.0	0.0	-0.0	0.1
Degree of sensitization stereotypy	0.2	0.2	0.4	0.5	-0.0	-0.6
Conditioned locomotion	0.5	0.5	1.0	-1.0	0.3	0.7
Cocaine response after cond. corrected	2.4	2.7	5.4	2.3	-1.3	-1.1
Cocaine response after cond. not corrected	1.6	1.8	3.5	1.9	0.2	-1.3
Cocaine response before conditioning	2.7	3.2	8.4	-1.1	2.9	-0.4
Saline control response	1.3	1.7	2.4	-1.6	1.0	1.3
Bone: connectivity density	0.1	0.2	0.4	-0.6	-0.1	0.4
Bone: cortical apparent density	0.2	0.3	0.6	0.3	-0.3	0.8
Bone: cortical area	0.5	0.7	1.6	-0.3	1.3	-0.6
Bone: cortical porosity	0.4	0.4	1.1	0.4	-1.0	-0.0
Bone: cortical porosity	0.4	0.5	0.6	0.7	-0.8	-0.6
Bone: cortical thickness	0.4	0.7	0.9	-0.9	-0.5	1.0
Bone: cortical thickness	0.4	0.4	0.5	-0.7	0.7	0.7
Bone: cortical tissue density	0.2	0.2	0.5	0.4	-0.3	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.6	-0.3	0.1
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.4	0.2	-1.2	0.2
Condit. Reinf. active responses	0.2	0.2	0.6	0.8	0.3	-0.1
Condit. Reinf. inactive responses	0.9	1.1	3.0	0.3	1.7	-0.3
Incentive salience index mean	0.1	0.1	0.2	0.3	0.5	-0.0
Condit. Reinf. lever presses	0.3	0.4	1.1	-0.2	1.1	-0.2
Condit. Reinf. active minus inactive responses	1.8	2.2	6.2	-0.4	2.5	-0.7
Condit. Reinf. active-inactive response ratio	2.2	2.3	4.2	0.6	2.0	-1.5
Condit. Reinf. active responses	2.0	2.8	7.0	-1.2	2.6	0.0
Condit. Reinf. inactive responses	1.0	1.2	2.2	-1.5	0.8	0.9
Condit. Reinf. lever presses	0.5	0.7	2.0	0.1	0.5	-1.4
Condit. Reinf. lever reinforcers received	2.2	3.1	7.8	-1.2	2.8	0.0
Conditioned reinforcement - actives	1.1	1.1	2.3	1.5	-0.0	-1.0
Conditioned reinforcement - inactives	2.2	2.5	6.9	-0.3	2.6	-0.6
Conditioned locomotion	1.1	1.4	2.8	1.7	0.2	-1.1
Patch foraging indifference point 0 sec	1.1	1.7	3.7	-1.9	-0.2	1.2
Patch foraging indifference point AUC	0.3	0.4	1.0	0.2	-1.0	0.1
Delay disc. indifference point, 0s delay	2.3	2.5	5.7	-2.4	0.6	1.2
Delay disc. indifference point, 16s delay	2.1	2.1	3.3	1.8	-1.4	-1.1
Delay disc. indifference point, 2s delay	0.7	0.8	1.4	-1.2	-0.1	1.0
Delay disc. indifference point, 24s delay	0.7	0.7	1.1	1.0	-1.0	-0.4
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.0	0.3	-0.2
Delay disc. indifference point, 8s delay	0.5	0.5	1.3	-1.1	-0.3	0.5
Indifference point function ln k	3.5	4.8	12.9	-1.3	3.6	-0.1
Indifference point function log k	3.5	4.8	12.9	-1.3	3.6	-0.1
Patch foraging total patch changes 0 sec	1.0	1.6	3.6	-1.9	-0.2	1.1
Patch foraging total patch changes 12 sec	0.4	0.5	1.5	0.2	-1.2	-0.0
Patch foraging total patch changes 18 sec	0.6	0.7	1.3	-0.6	-1.2	0.7
Patch foraging total patch changes 24 sec	0.8	1.0	1.6	1.3	-1.0	-0.6
Patch foraging total patch changes 6 sec	0.4	0.5	1.6	0.2	-1.2	0.0
Patch foraging time to switch 0 sec	6.1	9.5	14.0	3.7	-3.3	-1.9
Patch foraging water rate 0 sec	1.4	2.3	3.6	-1.9	1.6	0.9
Patch foraging water rate 12 sec	3.5	5.4	7.5	-2.7	2.6	1.3
Patch foraging water rate 18 sec	1.9	2.6	3.9	-2.0	1.6	1.2
Patch foraging water rate 24 sec	1.2	1.6	2.1	-1.4	1.5	0.9
Patch foraging water rate 6 sec	2.5	3.6	10.0	0.2	3.2	-0.9
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	6.7	-2.6	0.5	1.3
Distance traveled before self-admin	3.8	4.0	6.4	-2.5	2.2	0.9
Distance traveled after self-admin	4.6	5.1	11.4	-3.4	1.2	1.6
Extensor digitorum longus weight	0.2	0.8	1.8	0.5	0.6	-1.3
Bone: elastic displacement	0.7	0.8	1.3	-1.1	-0.3	1.0
Bone: elastic work	0.8	1.1	2.1	-1.4	1.0	0.3
Bone: endosteal estimation	1.8	3.9	6.3	0.9	2.5	-2.1
Bone: endosteal perimeter	1.1	2.4	4.9	0.3	2.2	-1.5
Epididymis fat weight	0.8	1.9	2.7	1.7	-1.4	-1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.0	-0.4	0.2
Delta time in open arm before/after self-admin	0.9	0.9	1.9	-0.9	1.4	0.2
Diff in mean of infusions in LGA sessions	2.2	2.4	5.3	-2.3	0.6	1.3
Delay discount exponential model param	0.4	0.5	0.8	0.9	0.6	-0.4
Extinction: sum of active levers before priming	2.7	2.7	5.5	-2.3	0.4	1.5
Active lever presses in extinction session 6	2.0	1.9	3.7	1.9	-1.0	-1.0
Bone: final force	1.0	1.6	3.3	0.5	1.8	-1.2
Bone: final moment	1.1	1.8	4.4	0.2	2.1	-1.0
Food consumed during 24 hour testing period	0.7	0.8	1.9	0.1	1.4	-0.7
Glucose	1.1	1.6	2.5	-1.6	-0.6	1.5
Heart weight	1.3	1.9	4.5	-1.0	2.1	-0.3
Delay discount hyperbolic model param	0.4	0.4	0.9	0.9	0.4	-0.4
Intermittent access intake day 1-15 change	0.7	0.7	2.1	-0.3	1.5	-0.1
Intermittent access intake escalation	0.5	0.5	1.4	0.3	1.2	-0.4
Intermittent access intake escalation 2	0.5	0.5	1.5	-0.2	1.2	-0.0
Intermitt. access day 1 inactive lever presses	3.1	3.4	5.9	2.4	1.0	-1.8
Intermitt. access day 15 inactive lever presses	4.2	4.6	7.6	2.8	1.0	-2.3
Intermitt. access escalation Index	0.5	0.5	0.8	-0.6	-0.9	0.6
Intermittent access day 1 total infusions	0.3	0.4	0.5	0.7	0.4	-0.7
Intermittent access day 15 total infusions	0.8	0.9	1.2	0.9	1.1	-0.9
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.1	1.1	1.0	-0.9
Intermittent access total infusions	0.9	1.0	1.3	1.1	0.9	-1.0
Intermittent access day 1 locomotion	0.3	0.3	0.7	0.2	0.9	-0.4
Intermittent access day 15 total locomotion	0.5	0.5	1.4	-0.4	1.2	-0.2
Intermittent access total locomotion	0.7	0.8	1.6	0.5	1.3	-0.7
Intermittent access standard deviation	1.6	1.7	3.7	1.9	-0.5	-1.0
Left kidney weight	1.9	5.2	10.9	0.7	3.3	-2.1
Right kidney weight	1.8	4.9	7.2	1.2	2.7	-2.5
Cocaine induced anxiety	1.3	1.5	3.7	-0.8	1.9	0.2
Post-drug Anxiety	1.0	1.1	2.4	1.5	0.1	-0.9
Baseline Anxiety	3.1	3.3	5.7	2.4	-1.7	-1.1
Tail length	0.8	2.4	5.6	-1.2	2.4	-0.5
Length with tail	1.2	4.4	7.2	1.2	2.7	-2.2
Length without tail	1.4	3.1	4.7	2.2	0.9	-2.0
Times rat made contact with spout	0.1	0.1	0.3	-0.1	-0.5	-0.4
Lifetime Intake	0.4	0.5	0.5	0.7	0.6	-0.7
Liver weight, left	2.1	3.3	6.4	2.5	-0.9	-1.6
Liver weight, right	1.2	2.0	3.3	1.8	-0.5	-1.6
Locomotor activity	0.1	0.2	0.5	0.1	-0.7	-0.3
Locomotor testing distance	0.2	0.3	0.6	0.4	-0.4	-0.8
Locomotor testing rearing	0.3	0.5	1.3	0.5	0.3	-1.1
Locomotion in novel chamber	0.8	1.0	1.9	-0.7	-1.4	0.8
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	-0.6	-0.7	0.3
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.5	0.7	-0.1
Change in fecal boli incidents, locomotor task	2.2	2.0	2.6	-1.2	-1.6	1.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.5	-0.7	-0.0
Bouts of movement, locomotor time 1	2.7	2.9	5.8	-2.4	1.2	1.2
Total resting periods, locomotor time 1	1.3	1.4	2.9	-1.7	0.5	1.1
Rest time, locomotor task time 1	0.9	1.0	1.4	0.8	1.2	-0.9
Distance moved, locomotor task time 1	0.4	0.4	0.5	-0.5	-0.7	0.7
Vertical activity count, locomotor time 1	3.1	3.2	5.9	-2.4	-0.7	1.8
Time >=10cm from walls, locomotor time 2	0.8	0.8	2.0	0.6	-1.4	0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	-0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.1	0.1	-0.4	-0.0	0.1
Rest time, locomotor task time 2	0.7	0.8	1.8	-1.4	0.2	0.7
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	-0.1	0.1
Vertical activity count, locomotor time 2	0.5	0.5	1.2	-1.1	-0.0	0.5
Light reinforcement 1	1.7	3.1	5.0	-2.2	0.6	2.0
Light reinforcement 2	1.1	1.5	3.0	-0.9	-0.9	1.7
Bone: marrow area	1.8	3.9	6.4	0.9	2.5	-2.1
Bone: maximum diameter	0.8	1.5	2.5	0.3	1.6	-1.4
Bone: maximum force	1.4	2.4	3.8	0.6	2.0	-1.8
Bone: maximum moment	1.5	2.6	5.1	0.3	2.3	-1.6
Mean time between licks in bursts	0.7	1.0	1.3	-1.1	-0.9	1.0
Mean num. licks in bursts	0.2	0.2	0.5	-0.1	-0.3	-0.7
Cd content in liver	0.9	0.9	1.5	-1.2	1.1	0.2
Co content in liver	0.8	0.9	1.9	-0.7	0.6	1.4
Cu content in liver	0.4	0.4	0.9	1.0	0.4	-0.5
Fe content in liver	0.2	0.3	0.7	-0.2	0.3	0.8
K content in liver	0.1	0.1	0.2	-0.3	0.1	0.5
Mg content in liver	0.2	0.2	0.4	0.3	-0.6	0.1
Mn content in liver	0.2	0.3	0.7	0.3	-0.8	-0.1
Na content in liver	1.5	1.6	2.3	-0.5	-1.5	1.5
Rb content in liver	0.1	0.1	0.2	0.4	0.3	-0.3
Se content in liver	1.1	1.3	3.8	0.4	-1.9	-0.2
Sr content in liver	5.8	5.3	8.1	-2.8	-1.7	2.2
Zn content in liver	1.0	1.1	2.2	1.5	-0.7	-0.8
Bone: minimum diameter	1.7	3.1	7.2	-0.0	2.7	-1.5
Time in familiar zone, hab. session 1	3.0	2.8	4.8	-1.9	2.2	0.5
Time in novel zone, hab. session 1	1.7	1.7	2.9	1.4	-1.7	0.3
Total zone transitions, hab. session 1	2.0	2.8	3.2	-1.7	1.6	1.8
Total locomotion distance, hab. session 1	1.9	2.6	4.3	-2.1	1.0	1.6
Locomotion velocity, hab. session 1	1.2	1.7	2.7	-1.7	0.8	1.3
Time in familiar zone, hab. session 2	2.1	2.2	3.3	1.3	1.2	-1.8
Time in novel zone, hab. session 2	0.9	0.9	1.3	-0.3	-1.2	1.1
Total zone transitions, hab. session 2	1.6	2.1	4.3	-1.3	2.1	0.5
Total locomotion distance, hab. session 2	1.4	1.8	3.8	-1.9	0.6	1.2
Locomotion velocity, hab. session 2	1.7	2.3	4.7	-2.2	0.6	1.4
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.3	0.0	-0.4
Novelty place preference	0.1	0.1	0.1	-0.3	0.3	-0.4
Time in novel zone, NPP test	0.1	0.1	0.2	-0.1	0.3	-0.5
Total zone transitions, NPP test	0.5	0.7	1.2	-1.1	0.7	0.7
Total locomotion distance, NPP test	0.2	0.3	0.8	-0.9	0.4	-0.1
Locomotion velocity, NPP test	0.5	0.7	1.6	-1.3	0.6	0.3
Intraocular pressure	0.1	0.2	0.5	-0.1	0.1	0.7
Delta distance traveled before/after self-admin	0.8	0.9	1.3	-1.1	-0.8	0.8
Delta ambulatory time before/after self-admin	0.8	0.9	1.5	-1.2	-0.7	0.9
Parametrial fat weight	2.0	3.8	11.2	0.1	-3.4	0.4
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.1	-0.0	0.4
Pavlov. Cond. magazine entry latency	0.6	0.8	1.1	0.6	-1.1	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.2	-0.3	0.3
Pavlov. Cond. index score	0.1	0.1	0.3	-0.1	-0.6	0.0
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.1	-0.5	-0.1
Pavlov. Cond. lever contacts	0.5	0.6	1.1	0.8	-0.1	-1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.2	0.6	0.1
Pavlov. Cond. intertrial magazine entries	1.7	2.1	3.3	-1.5	0.7	1.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.0	-0.6	-0.1
Pavlov. Cond. response bias	0.8	1.0	1.6	1.0	-0.6	-1.3
Pavlov. Cond. lever latency	0.7	1.0	2.3	1.5	0.7	-0.3
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	-0.2	-1.2	-0.3
Pavlov. Cond. change in total contacts	0.8	1.1	2.6	-1.6	0.8	0.3
Pavlov. Cond. index score	0.2	0.3	0.5	-0.7	-0.5	-0.3
Pavlov. Cond. latency score	0.3	0.4	0.5	-0.7	-0.7	-0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.8	-0.9	-0.2	-0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.3	0.7	0.2
Pavlov. Cond. intertrial magazine entries	1.3	1.7	4.7	0.5	2.2	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.6	-0.7	-0.3	-0.3
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.7	0.2	-0.5
Time in closed arm before self-admin	0.4	0.5	0.6	0.8	0.7	-0.7
Time in closed arm after self-admin	0.5	0.5	1.1	1.0	-0.2	-0.5
Time in open arm before self-admin	0.6	0.6	0.7	-0.8	-0.8	0.7
Time in open arm after self-admin	0.5	0.6	1.2	-1.1	-0.0	0.7
Bone: periosteal estimation	1.3	2.7	5.5	0.3	2.4	-1.6
Bone: periosteal perimeter	1.0	1.6	3.8	0.1	1.9	-1.0
Bone: post-yield work	1.9	2.5	4.1	1.5	1.1	-2.0
Progressive ratio test 1 active lever presses	0.8	0.8	1.8	-0.8	1.3	0.2
Progressive ratio test 1 breakpoint	0.7	0.7	1.6	-0.7	1.3	0.1
Progressive ratio test 1 inactive lever presses	1.6	1.7	4.2	0.5	2.1	-0.8
Progressive ratio test 2 active lever presses	0.6	0.6	1.2	0.4	1.1	-0.7
Progressive ratio test 2 breakpoint	0.8	0.9	1.5	0.7	1.2	-0.8
Progressive ratio test 2 inactive lever presses	1.4	1.6	3.8	0.4	1.9	-0.9
Incentive Sensitization - Responses	2.6	2.7	2.7	1.6	1.7	-1.6
Incentive Sensitization - Breakpoint	2.4	2.4	3.1	1.8	1.3	-1.6
Sum of active levers in priming session hrs 5-6	1.3	1.2	2.7	-1.6	0.4	0.9
Progressive ratio	1.1	1.3	2.7	-1.6	-0.1	1.0
Food seeking constrained by brief footshock	14.9	18.3	40.0	-6.3	1.6	3.5
Seeking ratio, punishment vs. effort	1.9	2.3	4.5	-2.1	1.2	1.0
Retroperitoneal fat weight	1.9	6.2	18.2	-0.0	-4.3	0.7
Reaction time number correct	0.6	0.9	2.2	-1.5	-0.2	0.7
Reaction time mean minus median	0.3	0.4	0.8	0.9	-0.3	-0.5
Reaction time mean minus median AUC	0.6	0.8	1.5	1.2	-0.5	-0.8
Reaction time num false alarms	0.1	0.2	0.4	-0.7	0.1	0.3
Reaction time num false alarms AUC	1.2	1.6	3.1	-1.7	-0.1	1.4
Reaction time trials correct on left	0.6	0.9	2.2	-1.5	-0.2	0.7
Reaction time trials on left	0.6	0.9	2.2	-1.5	-0.2	0.7
Reaction time mean	1.5	2.1	4.4	2.1	0.4	-1.3
Reaction time mean AUC	1.6	2.1	4.6	2.2	-0.1	-1.3
Median of all reaction times	1.0	1.4	2.9	1.7	0.4	-1.0
Reaction time omissions	0.3	0.4	0.7	-0.6	-0.2	0.8
Reaction time false alarm rate	0.3	0.5	0.8	-0.8	-0.0	0.9
Reaction time premature initiation rate	0.1	0.2	0.2	0.4	-0.3	-0.5
Reaction time premature initiations	0.1	0.1	0.3	-0.3	-0.5	-0.2
Std. dev. reaction times	0.8	1.1	2.2	1.5	0.2	-1.0
Reaction time trials completed	0.6	0.9	2.2	-1.5	-0.2	0.7
Reaction time trials AUC	0.4	0.6	1.6	-1.3	-0.3	0.4
Run reversals in cocaine runway, females	0.6	0.6	0.9	0.9	0.1	-0.9
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.7	0.1	-0.4
Latency to leave start box in cocaine runway	0.2	0.2	0.6	0.0	0.8	-0.2
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	0.5	-0.1
Latency to leave start box in cocaine runway, M	0.6	0.6	0.7	0.8	0.7	-0.7
Std. dev. time between licks in bursts	2.4	2.9	4.1	-2.0	0.8	2.0
Total sessions with >9 infusions	1.4	1.5	1.7	1.2	1.2	-1.3
Short access day 1 total inactive lever presses	2.4	2.7	5.3	2.3	0.1	-1.7
Short access day 10 total inactive lever presses	1.2	1.3	2.6	1.6	0.4	-1.1
Short access day 1 total infusions	0.0	0.0	0.1	-0.1	0.3	-0.2
Short access day 10 total infusions	0.4	0.5	1.0	1.0	-0.3	-0.6
Short access total infusions	0.1	0.1	0.2	-0.5	-0.4	0.3
Short access day 1 locomotion	0.6	0.7	0.9	1.0	0.6	-0.8
Short access day 10 total locomotion	0.6	0.7	1.8	-0.4	1.3	0.0
Short access total locomotion	0.8	0.8	1.7	-1.3	0.5	0.7
One hour access (0.3 mA shock)	2.1	2.4	3.1	1.5	1.8	-1.4
Compulsive drug intake	0.6	0.6	1.3	0.2	1.1	-0.6
One hour access (shock baseline)	2.5	2.9	6.2	2.5	0.2	-1.6
Social response proportion	1.3	1.4	2.3	1.5	0.8	-1.1
Social responses	1.7	2.2	3.1	1.4	1.8	-1.2
Social time	3.1	4.1	8.0	-2.0	2.8	0.7
Soleus weight	0.0	0.1	0.1	-0.3	0.3	-0.3
Bone: stiffness	1.5	2.3	3.0	1.2	1.7	-1.6
Tibialis anterior weight	0.4	1.4	3.2	-0.1	-1.8	-1.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	-0.1	0.8	-0.2
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.5	1.6	0.7	-0.9
Time to tail flick, test, before self-admin	6.5	6.3	12.4	-3.5	1.9	1.8
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.3	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.8	1.3	-0.3	-0.6
Delta time to tail flick, test, before/after SA	3.3	3.0	6.1	2.5	-1.1	-1.2
Tibia length	1.9	5.4	10.0	0.8	3.2	-2.4
Ambulatory time before self-admin	2.5	2.5	3.7	-1.9	1.9	0.7
Ambulatory time after self-admin	4.9	5.4	11.0	-3.3	1.8	1.4
Bone: tissue strength	2.0	1.9	4.4	-2.1	0.6	1.0
Total heroin consumption	0.8	0.9	1.0	-1.0	-0.9	0.9
Bone: trabecular number	0.4	0.7	1.5	-1.2	0.0	0.8
Bone: trabecular spacing	0.1	0.1	0.2	0.3	-0.4	-0.5
Bone: trabecular thickness	0.0	0.1	0.1	0.4	-0.1	-0.1
Bone: trabecular tissue density	2.3	3.2	5.2	2.3	-1.9	-0.8
Water consumed over 24 hours	1.0	1.2	2.4	-1.0	1.5	0.5
Number of responses in last shaping day	1.2	1.2	2.6	1.6	0.2	-1.0