Hub : Genes

Zfp423

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Zfp423 0.26 0.12 6.8e-07 0.22 0.18 0.18 0.21 4.3e-06 3.4e-05 3.7e-05 1.1e-05
2 IC gene expression Zfp423 0.3 0.13 6.4e-13 0.24 0.25 0.27 0.26 1.8e-10 9.3e-11 1.2e-11 2.9e-11
3 PL mRNA stability Zfp423 0.12 0.07 4.3e-05 0.04 0.02 0.04 0.03 1.4e-05 4.8e-03 4.3e-05 6.7e-04
4 pVTA gene expression Zfp423 0.16 0.09 1.4e-10 0.13 0.12 0.11 0.12 1.1e-10 9.6e-10 3.9e-09 7.6e-10
5 Adipose mRNA stability Zfp423 0.02 0.02 2.8e-03 0.02 0.02 0.02 0.02 9.0e-04 5.1e-03 2.4e-03 2.8e-03
6 Brain gene expression Zfp423 0.2 0.1 0.0e+00 0.26 0.26 0.26 0.26 4.5e-24 3.4e-24 2.6e-24 1.4e-24
7 OFC gene expression Zfp423 0.52 0.15 2.8e-13 0.38 0.41 0.38 0.41 5.3e-10 8.9e-11 4.2e-10 5.7e-11
8 Liver mRNA stability Zfp423 0.09 0.06 1.6e-10 0.09 0.09 0.09 0.09 1.4e-10 5.3e-10 2.9e-10 1.9e-10
9 NAcc intron excision ratio chr19_35467812_35555134 0.04 0.03 4.6e-04 0.02 0.02 0.01 0.02 2.9e-04 6.8e-04 3.7e-03 5.5e-04
10 LHb gene expression Zfp423 0.14 0.09 5.9e-03 0.03 0.01 0.04 0.03 7.2e-02 1.6e-01 5.0e-02 5.8e-02
11 IC mRNA stability Zfp423 0.08 0.06 6.6e-03 0.07 0.04 0.04 0.05 8.9e-04 1.2e-02 8.4e-03 3.5e-03
12 NAcc gene expression Zfp423 0.1 0.05 1.1e-16 0.09 0.1 0.1 0.1 7.2e-14 9.8e-15 2.6e-14 5.8e-15
13 PL gene expression Zfp423 0.75 0.14 0.0e+00 0.2 0.2 0.2 0.2 2.3e-21 1.9e-21 5.9e-21 1.9e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.83.44.22.02.11.81.9-1.8-2.0-1.91.9-1.61.72.0-1.6-1.7
Area under the delay curve0.10.20.5-0.5-0.20.5-0.40.70.30.0-0.10.60.00.20.50.3
BMI with tail1.96.58.7-2.9-2.6-1.7-2.92.92.71.3-2.62.9-2.3-2.02.92.8
BMI without tail0.10.30.7-0.6-0.20.4-0.70.60.3-0.8-0.20.80.10.30.70.5
Body weight0.52.03.3-1.2-1.5-1.6-1.21.21.21.2-1.61.1-1.8-1.81.31.4
Weight adjusted by age1.44.05.2-1.9-2.1-1.5-1.92.12.01.7-1.92.1-2.1-2.02.32.1
Bone surface1.32.73.71.81.81.51.6-1.6-1.8-1.91.7-1.41.61.7-1.3-1.4
Bone volume2.75.36.62.62.52.12.4-2.3-2.5-2.52.4-2.22.12.3-2.0-2.0
Breakpoint value in progressive ratio session0.40.72.80.4-0.2-1.70.4-0.7-0.31.4-0.2-0.8-0.6-1.0-0.8-0.5
Number of licking bursts0.10.40.70.50.50.70.6-0.6-0.6-0.10.6-0.80.60.5-0.8-0.8
Context. condit. distance diff. score3.23.86.2-2.0-2.1-1.4-2.02.32.02.5-2.02.2-1.8-1.91.81.2
Locomotion velocity, session 10.40.41.10.70.50.40.6-1.0-0.8-0.40.6-0.90.50.2-0.9-0.5
Locomotion distance, session 10.10.10.5-0.3-0.3-0.7-0.50.10.30.7-0.50.0-0.3-0.4-0.20.0
Locomotion velocity, session 20.00.00.1-0.1-0.1-0.1-0.2-0.1-0.00.2-0.1-0.2-0.0-0.3-0.2-0.0
Locomotion distance, session 20.50.71.6-0.7-0.9-1.2-0.80.60.61.3-0.90.5-0.9-1.10.40.4
Locomotion velocity, session 31.61.82.9-1.2-1.3-1.0-1.21.61.20.9-1.21.7-1.3-1.51.71.3
Locomotion distance, session 30.30.30.8-0.40.10.9-0.40.70.4-0.60.10.70.50.80.50.1
Stereotopy head waving bouts, day 30.30.30.9-0.7-0.5-0.1-0.70.70.50.3-0.51.0-0.3-0.00.90.5
Stereotopy head waving duration, day 30.70.81.4-1.0-0.9-0.7-1.00.90.70.9-0.91.2-0.8-0.61.10.9
Locomotion velocity, session 70.60.71.3-0.9-0.8-0.2-0.91.11.01.1-0.81.1-0.5-0.60.80.4
Locomotion distance, session 70.10.20.60.40.30.10.3-0.4-0.30.60.2-0.20.30.3-0.4-0.8
Stereotopy head waving bouts, day 70.30.40.9-0.7-0.20.7-0.50.80.5-0.6-0.21.00.10.41.00.6
Stereotopy head waving duration, day 70.70.82.60.40.91.50.6-0.4-0.7-1.60.9-0.21.11.3-0.2-0.3
Locomotion velocity, session 81.41.75.5-0.9-1.3-1.6-1.10.90.92.3-1.21.0-1.4-2.00.70.4
Locomotion distance, session 81.42.15.1-1.4-1.5-1.3-1.51.61.42.3-1.51.5-1.3-1.41.00.6
Degree of sensitization distance0.30.31.20.5-0.1-0.90.4-0.6-0.41.1-0.1-0.3-0.4-0.6-0.4-0.5
Degree of sensitization stereotypy0.30.30.8-0.6-0.20.7-0.40.80.5-0.6-0.00.80.10.30.90.6
Conditioned locomotion0.10.10.30.30.3-0.10.3-0.3-0.1-0.50.1-0.30.10.1-0.2-0.1
Cocaine response after cond. corrected2.74.07.3-1.8-2.1-2.5-2.11.31.82.7-2.21.5-2.2-2.31.41.5
Cocaine response after cond. not corrected2.23.15.6-1.5-1.9-2.4-1.80.91.52.3-1.91.3-2.0-2.21.21.4
Cocaine response before conditioning2.12.64.81.41.61.61.6-1.6-1.6-2.21.7-1.61.61.7-1.4-1.1
Saline control response1.21.73.71.41.20.51.4-1.4-1.3-0.11.1-1.51.20.9-1.9-1.9
Bone: connectivity density1.93.14.61.71.92.11.5-1.5-1.7-1.91.8-1.31.92.1-1.4-1.6
Bone: cortical apparent density0.20.31.5-0.30.31.2-0.10.60.2-0.30.20.70.50.80.4-0.1
Bone: cortical area0.20.40.80.90.70.20.8-0.5-0.7-0.60.6-0.70.40.6-0.6-0.6
Bone: cortical porosity0.10.10.30.0-0.1-0.5-0.10.20.20.2-0.20.2-0.5-0.20.20.2
Bone: cortical porosity0.10.10.30.50.50.20.4-0.2-0.3-0.40.4-0.10.10.5-0.2-0.4
Bone: cortical thickness0.00.10.20.30.30.20.30.1-0.2-0.50.2-0.10.00.3-0.0-0.1
Bone: cortical thickness0.10.10.5-0.0-0.2-0.3-0.00.40.40.7-0.20.3-0.3-0.30.2-0.0
Bone: cortical tissue density0.20.31.5-0.40.21.2-0.20.70.3-0.20.10.80.50.80.5-0.0
Condit. Reinf. active minus inactive responses0.60.71.3-1.1-0.20.9-1.11.11.0-0.4-0.41.00.41.00.70.4
Condit. Reinf. active-inactive response ratio1.01.12.2-1.4-1.0-0.4-1.51.31.40.7-1.21.1-0.6-0.30.90.8
Condit. Reinf. active responses0.91.13.70.21.01.90.2-0.0-0.3-1.70.9-0.11.51.9-0.3-0.6
Condit. Reinf. inactive responses5.16.68.52.72.82.82.7-2.2-2.7-2.82.9-2.12.72.6-2.0-2.3
Incentive salience index mean1.31.65.30.41.22.10.3-0.4-0.5-1.71.1-0.51.82.3-0.8-0.9
Condit. Reinf. lever presses2.84.27.31.52.22.61.4-1.5-1.7-2.52.1-1.82.52.7-1.9-1.8
Condit. Reinf. active minus inactive responses0.20.30.6-0.3-0.6-0.7-0.40.40.50.8-0.50.5-0.7-0.70.60.4
Condit. Reinf. active-inactive response ratio0.40.71.3-0.5-0.8-1.1-0.70.50.60.6-0.80.4-1.1-1.10.81.1
Condit. Reinf. active responses0.10.10.50.1-0.2-0.60.00.10.10.7-0.20.3-0.4-0.50.3-0.0
Condit. Reinf. inactive responses0.10.21.10.0-0.3-0.70.00.20.21.1-0.20.6-0.3-0.50.3-0.3
Condit. Reinf. lever presses0.40.50.8-0.7-0.7-0.8-0.60.70.80.7-0.80.9-0.7-0.70.80.6
Condit. Reinf. lever reinforcers received0.30.40.8-0.3-0.6-0.9-0.30.40.50.8-0.50.7-0.7-0.80.60.4
Conditioned reinforcement - actives0.00.10.30.40.1-0.60.3-0.1-0.10.20.1-0.2-0.0-0.1-0.3-0.4
Conditioned reinforcement - inactives0.10.20.6-0.4-0.6-0.8-0.50.30.40.7-0.40.4-0.5-0.50.30.1
Conditioned locomotion0.10.10.30.40.3-0.00.5-0.2-0.3-0.00.3-0.30.20.1-0.3-0.4
Patch foraging indifference point 0 sec0.20.61.4-0.9-0.7-0.4-0.81.20.80.9-0.71.1-0.4-0.40.80.4
Patch foraging indifference point AUC0.40.81.61.20.8-0.01.0-1.2-1.1-0.20.9-1.20.60.4-1.1-1.0
Delay disc. indifference point, 0s delay1.11.21.71.11.11.01.3-1.2-1.1-0.91.2-1.11.11.0-1.1-1.1
Delay disc. indifference point, 16s delay0.50.71.1-0.8-0.8-0.6-0.81.00.80.8-0.90.9-0.9-0.81.00.8
Delay disc. indifference point, 2s delay0.20.30.7-0.4-0.10.5-0.50.70.3-0.6-0.10.80.10.30.90.5
Delay disc. indifference point, 24s delay0.00.00.2-0.00.10.40.20.0-0.2-0.30.3-0.00.20.3-0.0-0.1
Delay disc. indifference point, 4s delay0.10.10.6-0.30.10.8-0.10.30.20.00.20.30.50.50.1-0.2
Delay disc. indifference point, 8s delay0.30.61.3-1.1-0.70.1-0.81.10.90.4-0.61.0-0.4-0.20.90.7
Indifference point function ln k0.41.22.4-1.5-0.80.1-1.41.51.3-0.1-1.01.5-0.4-0.11.31.1
Indifference point function log k0.41.22.4-1.5-0.80.1-1.41.51.3-0.1-1.01.5-0.4-0.11.31.1
Patch foraging total patch changes 0 sec0.30.91.7-1.0-1.0-0.6-1.01.30.91.2-0.91.3-0.7-0.61.00.6
Patch foraging total patch changes 12 sec0.40.61.60.80.70.30.6-0.7-0.70.20.6-0.70.80.6-1.0-1.3
Patch foraging total patch changes 18 sec0.71.62.81.51.20.51.4-1.4-1.4-0.31.3-1.41.10.9-1.5-1.7
Patch foraging total patch changes 24 sec0.31.12.41.21.00.61.2-0.8-1.1-0.11.1-0.81.10.9-1.1-1.6
Patch foraging total patch changes 6 sec0.10.20.40.50.40.30.4-0.2-0.40.10.4-0.30.50.4-0.5-0.7
Patch foraging time to switch 0 sec0.00.00.20.10.20.50.1-0.1-0.1-0.20.10.00.20.2-0.1-0.3
Patch foraging water rate 0 sec0.00.10.40.3-0.1-0.60.2-0.2-0.20.10.0-0.2-0.2-0.3-0.10.1
Patch foraging water rate 12 sec0.41.63.50.91.21.90.8-0.9-1.0-1.81.3-0.91.51.6-0.9-0.8
Patch foraging water rate 18 sec2.14.89.41.92.23.01.8-1.8-2.0-3.12.1-2.02.32.5-1.7-1.5
Patch foraging water rate 24 sec0.30.41.50.00.51.2-0.1-0.2-0.3-1.10.4-0.20.70.9-0.2-0.1
Patch foraging water rate 6 sec3.45.06.92.52.31.82.6-2.5-2.4-1.82.3-2.32.01.9-2.3-2.3
Seeking ratio, delayed vs. immediate footshock3.55.07.2-2.5-2.2-1.5-2.62.72.51.5-2.32.7-1.9-1.72.52.1
Distance traveled before self-admin1.43.04.4-1.9-1.8-1.6-1.91.71.90.8-1.71.7-1.6-1.41.92.1
Distance traveled after self-admin0.10.20.7-0.3-0.2-0.2-0.30.20.3-0.8-0.20.2-0.3-0.10.50.9
Extensor digitorum longus weight0.00.10.30.3-0.1-0.50.2-0.2-0.1-0.5-0.1-0.3-0.6-0.50.10.5
Bone: elastic displacement0.00.00.10.10.20.30.10.20.0-0.20.10.20.00.10.0-0.2
Bone: elastic work0.00.00.10.20.30.00.2-0.1-0.1-0.30.1-0.00.10.3-0.0-0.0
Bone: endosteal estimation0.20.41.4-0.3-0.7-1.2-0.40.20.41.1-0.7-0.0-0.7-1.00.00.3
Bone: endosteal perimeter0.20.41.5-0.4-0.7-1.2-0.50.40.51.2-0.70.2-0.7-0.80.10.1
Epididymis fat weight0.31.32.6-1.0-1.2-1.6-1.00.81.01.4-1.30.9-1.3-1.40.80.9
Delta time in closed arm before/after self-admin0.30.30.6-0.8-0.5-0.1-0.70.60.60.0-0.40.7-0.2-0.10.60.6
Delta time in open arm before/after self-admin0.50.61.01.00.4-0.90.9-0.9-0.80.60.5-1.0-0.1-0.4-0.9-0.7
Diff in mean of infusions in LGA sessions0.20.41.9-0.2-0.4-1.1-0.20.20.31.4-0.50.1-0.5-0.7-0.1-0.3
Delay discount exponential model param0.10.20.40.50.1-0.70.3-0.6-0.20.10.0-0.6-0.2-0.4-0.5-0.2
Extinction: sum of active levers before priming3.04.56.2-2.5-2.2-1.6-2.52.22.21.7-2.22.2-2.0-1.82.22.3
Active lever presses in extinction session 60.10.10.8-0.40.00.4-0.40.10.2-0.9-0.10.10.20.40.20.4
Bone: final force1.11.83.01.51.40.61.5-1.7-1.5-1.41.3-1.71.11.1-1.4-1.0
Bone: final moment0.71.11.81.21.10.41.2-1.3-1.1-1.21.0-1.30.90.8-1.1-0.7
Food consumed during 24 hour testing period2.85.79.22.72.31.32.7-2.8-2.5-1.02.3-3.02.01.6-3.0-2.7
Glucose0.50.81.81.30.80.21.1-1.4-1.2-0.10.9-1.00.40.3-0.9-1.0
Heart weight0.50.71.6-1.1-0.70.1-1.31.21.00.5-0.81.2-0.3-0.11.00.6
Delay discount hyperbolic model param0.10.20.70.50.0-0.80.3-0.6-0.20.3-0.1-0.6-0.3-0.5-0.4-0.1
Intermittent access intake day 1-15 change1.16.18.22.52.41.92.4-2.6-2.6-2.22.5-2.72.42.2-2.9-2.6
Intermittent access intake escalation0.94.66.32.12.11.62.1-2.3-2.2-2.12.1-2.42.11.9-2.5-2.3
Intermittent access intake escalation 22.23.75.11.81.91.51.7-2.0-2.0-1.71.9-2.02.11.9-2.3-2.2
Intermitt. access day 1 inactive lever presses0.00.10.3-0.40.10.3-0.20.10.2-0.00.10.20.40.6-0.0-0.1
Intermitt. access day 15 inactive lever presses0.21.21.8-1.2-1.2-1.2-1.31.01.11.4-1.21.0-1.1-1.10.90.8
Intermitt. access escalation Index0.10.20.3-0.4-0.00.5-0.60.50.3-0.40.10.50.30.40.40.3
Intermittent access day 1 total infusions1.03.14.6-1.6-1.9-2.1-1.51.61.71.8-1.61.6-2.0-2.01.71.7
Intermittent access day 15 total infusions0.00.10.6-0.1-0.3-0.8-0.20.10.1-0.1-0.2-0.0-0.4-0.40.00.3
Intermittent access terminal intake (last 3 days)0.20.31.3-0.3-0.5-1.2-0.40.50.40.5-0.40.3-0.6-0.70.20.3
Intermittent access total infusions0.20.31.4-0.1-0.4-1.2-0.20.20.20.5-0.40.1-0.6-0.80.20.3
Intermittent access day 1 locomotion0.00.10.3-0.3-0.2-0.3-0.20.40.2-0.20.00.3-0.2-0.20.40.6
Intermittent access day 15 total locomotion0.10.41.2-0.4-0.7-1.1-0.40.40.40.3-0.50.2-0.9-0.90.50.9
Intermittent access total locomotion0.30.41.9-0.3-0.6-1.4-0.30.30.30.5-0.40.1-0.9-1.00.40.7
Intermittent access standard deviation0.31.52.21.21.11.11.3-1.3-1.3-0.71.0-1.41.21.0-1.4-1.5
Left kidney weight0.43.44.11.81.91.71.8-2.0-2.0-1.91.8-2.01.71.7-1.9-1.7
Right kidney weight0.10.50.90.90.70.20.9-1.0-0.9-0.50.6-0.90.50.4-0.9-0.8
Cocaine induced anxiety0.10.40.8-0.8-0.40.0-0.80.90.90.5-0.60.9-0.1-0.10.50.1
Post-drug Anxiety0.40.40.8-0.6-0.6-0.5-0.80.70.80.7-0.90.7-0.6-0.60.50.3
Baseline Anxiety0.10.20.40.6-0.0-0.50.3-0.6-0.50.10.1-0.6-0.4-0.5-0.30.1
Tail length0.84.15.62.32.01.32.4-2.3-2.3-1.52.0-2.31.61.4-2.2-2.1
Length with tail0.10.61.51.00.4-0.41.1-1.2-0.90.30.4-1.2-0.2-0.4-1.0-0.7
Length without tail0.31.74.2-0.7-1.4-1.9-0.60.61.01.9-1.40.5-1.9-2.00.70.9
Times rat made contact with spout0.30.30.90.50.70.80.5-0.4-0.4-0.90.6-0.40.60.7-0.3-0.3
Lifetime Intake0.20.21.30.1-0.3-1.1-0.10.00.10.6-0.2-0.0-0.5-0.7-0.00.0
Liver weight, left0.10.20.30.40.3-0.10.5-0.6-0.50.10.2-0.50.1-0.0-0.6-0.6
Liver weight, right0.00.00.20.0-0.1-0.50.1-0.00.0-0.0-0.1-0.1-0.3-0.3-0.00.1
Locomotor activity0.20.31.0-0.1-0.4-1.0-0.10.20.10.6-0.40.4-0.7-0.80.60.5
Locomotor testing distance0.10.30.9-0.2-0.5-1.0-0.20.20.20.6-0.30.5-0.6-0.70.50.4
Locomotor testing rearing0.20.61.50.90.60.10.7-0.9-0.80.20.6-0.90.50.3-1.1-1.2
Locomotion in novel chamber0.40.61.0-0.7-0.8-1.0-0.70.50.70.9-1.00.6-0.9-0.90.70.6
Locomotion in novel chamber post-restriction0.31.01.50.70.91.10.8-1.0-0.9-1.20.9-1.21.01.1-1.0-0.6
Fecal boli incidents, locomotor time 10.30.81.91.20.9-0.01.2-0.9-0.9-0.10.7-1.00.50.3-1.2-1.4
Change in fecal boli incidents, locomotor task0.50.52.7-0.10.51.70.00.1-0.2-0.50.80.21.01.1-0.0-0.4
Time >=10cm from walls, locomotor time 10.30.41.20.50.70.60.6-0.4-0.7-1.10.9-0.50.70.8-0.4-0.2
Bouts of movement, locomotor time 10.60.81.30.80.91.20.8-0.8-0.8-0.60.7-0.91.01.0-1.0-1.0
Total resting periods, locomotor time 10.40.41.20.40.71.10.4-0.5-0.4-0.60.5-0.60.80.9-0.7-0.7
Rest time, locomotor task time 10.30.51.00.60.70.90.5-0.6-0.6-1.00.4-0.60.70.8-0.6-0.5
Distance moved, locomotor task time 10.30.81.3-0.8-0.9-1.1-0.70.80.91.1-0.60.9-0.8-0.90.80.8
Vertical activity count, locomotor time 10.10.40.90.90.4-0.70.9-0.8-0.70.40.7-0.70.1-0.2-0.7-0.6
Time >=10cm from walls, locomotor time 20.20.61.5-0.5-0.8-1.2-0.50.70.80.3-0.60.6-1.0-1.00.81.1
Bouts of movement, locomotor time 20.10.20.7-0.30.20.8-0.20.30.2-0.70.20.30.50.60.20.1
Total resting periods, locomotor time 20.10.20.8-0.00.40.90.10.1-0.0-0.60.40.00.70.8-0.1-0.3
Rest time, locomotor task time 20.10.20.60.60.50.40.5-0.3-0.40.10.2-0.20.30.3-0.4-0.8
Distance moved, locomotor task time 21.82.43.7-1.7-1.6-1.6-1.61.31.61.0-1.41.3-1.5-1.51.51.9
Vertical activity count, locomotor time 20.10.21.10.50.1-1.00.5-0.6-0.30.40.2-0.4-0.1-0.3-0.4-0.2
Light reinforcement 15.324.131.65.65.03.45.5-5.2-5.2-3.65.0-5.34.54.0-5.4-5.3
Light reinforcement 25.712.818.94.33.62.24.2-4.0-3.9-2.43.6-4.13.02.6-4.0-3.8
Bone: marrow area0.20.51.5-0.4-0.7-1.2-0.40.30.41.1-0.70.0-0.7-1.00.10.3
Bone: maximum diameter0.10.20.5-0.5-0.5-0.6-0.50.70.60.4-0.50.4-0.3-0.20.40.4
Bone: maximum force0.10.20.70.60.3-0.50.5-0.8-0.5-0.10.2-0.80.0-0.1-0.6-0.2
Bone: maximum moment0.00.10.30.30.1-0.50.2-0.4-0.20.1-0.1-0.5-0.1-0.2-0.3-0.0
Mean time between licks in bursts0.00.31.0-0.10.31.0-0.20.40.1-0.70.20.50.60.80.2-0.3
Mean num. licks in bursts0.00.10.5-0.20.00.1-0.20.40.3-0.7-0.10.5-0.00.20.50.5
Cd content in liver3.13.45.4-2.3-2.0-1.4-1.92.12.22.2-2.01.6-1.5-1.61.31.5
Co content in liver1.11.32.7-1.6-1.1-0.3-1.41.61.40.7-1.21.4-0.5-0.41.21.1
Cu content in liver0.00.00.1-0.1-0.1-0.1-0.10.20.1-0.1-0.00.10.1-0.00.10.2
Fe content in liver2.12.67.61.41.61.71.4-1.7-1.5-2.81.6-1.71.31.7-1.2-0.6
K content in liver0.90.91.7-0.9-0.9-1.0-1.10.71.00.3-1.00.9-0.9-0.71.11.3
Mg content in liver0.60.71.1-0.8-0.8-0.8-0.90.80.90.4-0.81.0-0.6-0.61.00.9
Mn content in liver1.21.42.1-1.1-1.2-1.3-1.21.21.11.4-1.11.4-0.9-1.11.20.9
Na content in liver0.10.10.60.30.2-0.20.2-0.5-0.1-0.80.2-0.40.00.1-0.10.3
Rb content in liver0.80.91.31.01.10.91.0-0.8-1.0-1.21.0-0.81.01.0-0.8-0.9
Se content in liver1.51.83.01.61.40.91.4-1.6-1.5-1.71.4-1.61.01.0-1.2-0.8
Sr content in liver0.50.40.6-0.8-0.8-0.7-0.80.60.80.5-0.80.5-0.6-0.50.50.7
Zn content in liver2.12.43.0-1.6-1.6-1.4-1.71.71.71.2-1.61.7-1.3-1.21.71.6
Bone: minimum diameter0.61.12.21.21.00.51.1-1.2-1.2-0.91.0-1.50.70.7-1.3-1.0
Time in familiar zone, hab. session 10.91.02.20.60.91.50.8-0.9-0.7-1.11.0-0.91.11.0-1.0-0.9
Time in novel zone, hab. session 10.60.61.2-0.7-0.7-0.8-0.80.90.70.3-0.80.9-0.8-0.41.11.1
Total zone transitions, hab. session 10.20.30.8-0.4-0.5-0.9-0.50.70.50.9-0.60.4-0.6-0.60.40.3
Total locomotion distance, hab. session 10.81.11.9-0.9-1.0-1.4-0.91.10.91.4-1.00.9-1.1-1.20.80.8
Locomotion velocity, hab. session 10.71.02.1-0.7-0.9-1.4-0.81.10.81.4-0.90.8-1.1-1.10.70.7
Time in familiar zone, hab. session 21.61.93.01.41.41.31.3-1.3-1.5-0.91.4-1.21.51.2-1.5-1.7
Time in novel zone, hab. session 24.24.56.1-2.2-2.2-2.1-2.12.12.31.6-2.32.0-2.3-1.82.32.5
Total zone transitions, hab. session 20.10.10.50.20.40.40.1-0.0-0.30.00.3-0.20.50.7-0.3-0.5
Total locomotion distance, hab. session 20.10.20.8-0.1-0.3-0.8-0.10.40.20.9-0.30.3-0.5-0.30.30.1
Locomotion velocity, hab. session 20.10.10.50.2-0.1-0.70.10.1-0.00.7-0.1-0.0-0.3-0.1-0.0-0.1
Novel to familiar place preference ratio1.11.52.0-1.3-1.3-1.1-1.41.11.40.9-1.41.2-1.2-0.91.31.4
Novelty place preference1.11.31.8-1.2-1.2-1.2-1.30.91.30.9-1.31.0-1.3-1.11.11.3
Time in novel zone, NPP test0.91.01.8-1.1-1.1-0.9-1.20.81.10.5-1.20.9-1.1-0.81.11.3
Total zone transitions, NPP test0.00.00.20.10.0-0.5-0.00.1-0.10.5-0.10.2-0.1-0.10.1-0.2
Total locomotion distance, NPP test0.10.10.3-0.2-0.2-0.4-0.20.60.20.2-0.20.5-0.3-0.10.50.3
Locomotion velocity, NPP test0.10.10.40.0-0.2-0.6-0.10.30.00.5-0.20.3-0.3-0.30.20.0
Intraocular pressure3.65.88.3-2.7-2.4-1.8-2.72.92.82.1-2.42.7-2.1-1.72.52.3
Delta distance traveled before/after self-admin2.42.63.31.81.71.41.7-1.7-1.7-1.81.6-1.61.51.5-1.5-1.4
Delta ambulatory time before/after self-admin2.74.75.22.32.32.02.2-2.1-2.3-2.22.2-2.12.22.1-2.1-2.0
Parametrial fat weight0.10.31.9-0.1-0.4-0.6-0.1-0.00.01.4-0.6-0.2-0.6-0.8-0.3-0.5
Pavlov. Cond. lever latency0.10.10.5-0.2-0.3-0.3-0.1-0.00.10.7-0.30.1-0.3-0.30.0-0.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.3-0.00.4-0.30.30.2-0.6-0.00.20.10.20.30.3
Pavlov. Cond. change in total contacts1.21.23.60.91.11.10.9-1.0-1.0-1.91.1-1.21.11.0-0.9-0.6
Pavlov. Cond. index score0.10.10.3-0.4-0.10.3-0.50.50.4-0.6-0.10.30.00.20.40.5
Pavlov. Cond. latency score0.10.10.3-0.4-0.20.1-0.50.50.4-0.3-0.20.3-0.00.00.30.3
Pavlov. Cond. lever contacts0.10.10.80.10.20.4-0.00.1-0.1-0.90.20.00.30.30.10.1
Pavlov. Cond. magazine entry number0.10.10.70.40.1-0.40.3-0.4-0.30.90.0-0.2-0.0-0.2-0.4-0.5
Pavlov. Cond. intertrial magazine entries0.00.10.2-0.00.10.20.10.2-0.0-0.00.20.50.20.40.3-0.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.5-0.6-0.4-0.0-0.60.70.6-0.3-0.40.5-0.2-0.00.60.7
Pavlov. Cond. response bias0.30.32.3-0.00.40.90.00.2-0.1-1.50.40.10.50.80.30.3
Pavlov. Cond. lever latency0.50.71.0-0.7-0.9-0.9-0.80.80.80.9-0.90.7-1.0-1.00.80.9
Pavlov. Cond. magazine entry latency0.10.10.20.20.30.20.1-0.4-0.2-0.20.2-0.30.30.3-0.4-0.4
Pavlov. Cond. change in total contacts0.10.20.80.20.40.80.2-0.3-0.2-0.90.4-0.20.60.7-0.2-0.3
Pavlov. Cond. index score0.10.20.40.30.40.50.2-0.5-0.3-0.70.4-0.30.50.6-0.3-0.4
Pavlov. Cond. latency score0.10.10.40.20.40.40.2-0.5-0.2-0.60.3-0.30.40.5-0.3-0.3
Pavlov. Cond. lever contacts0.91.41.71.11.31.21.2-1.1-1.1-1.21.2-1.01.31.3-1.1-1.2
Pavlov. Cond. magazine entry number0.00.00.1-0.0-0.00.10.10.2-0.00.20.10.10.00.00.10.1
Pavlov. Cond. intertrial magazine entries0.40.91.41.11.00.81.2-0.8-1.1-0.51.1-0.80.90.9-0.8-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.20.40.50.2-0.5-0.2-0.70.3-0.30.50.6-0.3-0.3
Pavlov. Cond. response bias0.40.50.60.70.70.60.7-0.8-0.7-0.80.7-0.60.70.7-0.7-0.7
Time in closed arm before self-admin3.45.98.82.22.62.92.2-2.1-2.3-3.02.3-2.22.72.8-2.1-2.0
Time in closed arm after self-admin2.32.65.21.11.72.21.2-1.2-1.4-2.31.4-1.21.92.1-1.2-1.1
Time in open arm before self-admin1.92.33.2-1.6-1.6-1.3-1.51.51.61.8-1.61.5-1.5-1.51.31.2
Time in open arm after self-admin1.92.14.8-1.1-1.5-2.2-1.11.11.21.8-1.31.1-1.8-1.91.21.2
Bone: periosteal estimation0.00.10.30.40.1-0.50.3-0.3-0.30.20.1-0.5-0.0-0.1-0.5-0.3
Bone: periosteal perimeter0.00.00.2-0.0-0.1-0.4-0.10.10.10.4-0.20.2-0.0-0.00.0-0.1
Bone: post-yield work0.20.41.1-0.3-0.7-1.0-0.40.30.21.1-0.6-0.2-0.7-1.0-0.10.3
Progressive ratio test 1 active lever presses0.10.21.5-0.0-0.4-1.2-0.10.20.30.2-0.20.0-0.7-0.80.20.5
Progressive ratio test 1 breakpoint0.10.21.3-0.0-0.4-1.1-0.20.20.30.2-0.20.0-0.6-0.70.20.5
Progressive ratio test 1 inactive lever presses0.00.10.4-0.4-0.4-0.7-0.30.30.40.3-0.00.2-0.3-0.30.20.3
Progressive ratio test 2 active lever presses0.20.31.4-0.2-0.6-1.2-0.40.40.50.4-0.50.2-0.7-0.80.30.6
Progressive ratio test 2 breakpoint0.30.41.6-0.3-0.7-1.3-0.50.50.60.5-0.60.3-0.8-0.90.40.7
Progressive ratio test 2 inactive lever presses0.61.92.9-1.3-1.5-1.7-1.41.31.41.4-1.31.2-1.4-1.41.21.2
Incentive Sensitization - Responses0.00.10.4-0.2-0.4-0.6-0.30.30.40.5-0.40.2-0.4-0.40.10.2
Incentive Sensitization - Breakpoint0.00.10.3-0.1-0.4-0.6-0.20.20.30.5-0.30.1-0.3-0.40.00.1
Sum of active levers in priming session hrs 5-60.60.61.7-0.6-0.8-1.3-0.50.40.61.1-0.70.4-0.9-1.00.40.5
Progressive ratio0.10.30.60.80.6-0.10.7-0.7-0.5-0.40.6-0.50.30.3-0.5-0.5
Food seeking constrained by brief footshock2.53.13.81.91.81.51.8-1.8-1.9-1.41.7-1.91.81.7-1.9-1.9
Seeking ratio, punishment vs. effort0.51.11.51.01.01.01.0-1.0-1.2-0.80.9-1.21.00.9-1.2-1.1
Retroperitoneal fat weight0.52.26.0-1.1-1.4-2.1-1.21.21.22.5-1.71.1-1.6-1.80.80.5
Reaction time number correct0.20.61.5-1.1-0.7-0.1-0.80.90.7-0.1-0.51.2-0.3-0.11.11.0
Reaction time mean minus median0.21.52.3-1.0-1.2-1.2-1.11.41.30.7-1.31.2-1.5-1.41.41.5
Reaction time mean minus median AUC0.32.33.2-1.3-1.6-1.6-1.41.51.51.1-1.61.3-1.8-1.71.51.7
Reaction time num false alarms3.66.17.4-2.6-2.6-2.1-2.62.72.62.6-2.62.6-2.3-2.22.42.1
Reaction time num false alarms AUC2.04.66.4-2.4-2.3-1.5-2.42.52.32.0-2.22.4-1.8-1.72.11.8
Reaction time trials correct on left0.20.61.5-1.1-0.7-0.1-0.80.90.7-0.1-0.51.2-0.3-0.11.11.0
Reaction time trials on left0.20.81.7-1.2-0.8-0.2-0.91.00.90.0-0.61.3-0.5-0.31.21.1
Reaction time mean2.76.07.7-2.6-2.6-1.9-2.72.52.61.6-2.82.1-2.6-2.42.32.8
Reaction time mean AUC2.56.17.9-2.6-2.7-1.9-2.72.52.61.7-2.82.0-2.7-2.52.32.8
Median of all reaction times3.55.47.3-2.6-2.5-1.7-2.72.32.51.5-2.72.0-2.4-2.32.22.6
Reaction time omissions2.54.15.3-1.9-2.2-1.9-2.01.81.82.0-2.21.9-2.3-2.22.01.9
Reaction time false alarm rate1.52.13.3-1.5-1.6-1.2-1.61.61.51.8-1.61.4-1.3-1.41.21.0
Reaction time premature initiation rate3.25.08.32.42.31.72.2-2.4-2.3-0.92.1-2.32.21.9-2.7-2.9
Reaction time premature initiations0.82.34.11.61.61.31.5-1.6-1.5-0.71.5-1.41.61.5-1.7-2.0
Std. dev. reaction times0.82.73.8-1.5-1.7-1.5-1.61.61.61.3-1.81.3-1.9-1.81.61.9
Reaction time trials completed0.20.81.7-1.2-0.8-0.2-0.91.00.90.0-0.61.3-0.5-0.31.21.1
Reaction time trials AUC0.20.81.9-1.2-0.8-0.3-1.01.10.90.0-0.71.4-0.5-0.31.31.1
Run reversals in cocaine runway, females1.41.55.2-0.6-1.2-2.3-0.60.50.71.5-1.10.6-1.7-1.80.81.1
Run reversals in cocaine runway, males0.20.20.4-0.5-0.4-0.1-0.60.40.5-0.4-0.30.4-0.3-0.20.50.7
Latency to leave start box in cocaine runway1.01.33.5-1.0-1.3-1.9-0.90.71.01.6-1.10.5-1.4-1.50.61.0
Latency to leave start box in cocaine runway, F1.62.03.8-1.3-1.6-2.0-1.21.01.21.2-1.50.9-1.7-1.71.21.6
Latency to leave start box in cocaine runway, M0.20.20.80.10.0-0.50.2-0.4-0.10.90.3-0.60.1-0.1-0.8-0.7
Std. dev. time between licks in bursts0.30.61.30.60.81.20.6-0.4-0.6-0.90.8-0.31.01.0-0.5-0.8
Total sessions with >9 infusions0.00.00.3-0.1-0.1-0.5-0.20.20.2-0.30.10.1-0.0-0.00.10.3
Short access day 1 total inactive lever presses0.10.11.20.3-0.1-1.10.3-0.3-0.10.10.1-0.1-0.3-0.4-0.00.1
Short access day 10 total inactive lever presses0.10.61.70.30.71.30.5-0.8-0.7-0.50.5-0.60.91.0-0.7-0.9
Short access day 1 total infusions0.30.71.0-0.7-0.8-1.0-0.90.90.90.6-0.51.0-0.7-0.70.90.9
Short access day 10 total infusions0.10.10.60.1-0.2-0.80.10.10.10.50.10.0-0.3-0.4-0.0-0.1
Short access total infusions0.10.20.8-0.1-0.3-0.9-0.20.30.30.5-0.10.2-0.4-0.50.20.2
Short access day 1 locomotion1.62.63.9-1.3-1.6-2.0-1.61.71.71.4-1.51.7-1.6-1.51.71.7
Short access day 10 total locomotion0.00.10.3-0.5-0.30.2-0.40.40.3-0.1-0.20.4-0.10.00.40.3
Short access total locomotion0.40.50.8-0.8-0.7-0.8-0.90.90.80.4-0.70.8-0.6-0.50.80.8
One hour access (0.3 mA shock)0.80.92.5-0.6-1.0-1.6-0.80.60.71.6-1.00.5-1.0-1.20.40.3
Compulsive drug intake0.20.21.4-0.20.31.2-0.10.2-0.0-0.50.30.10.70.8-0.0-0.4
One hour access (shock baseline)0.41.03.6-0.5-1.0-1.9-0.70.50.71.5-1.00.4-1.2-1.40.40.5
Social response proportion0.40.51.0-0.5-0.8-0.8-0.70.40.60.6-0.90.3-1.0-1.00.50.7
Social responses0.30.41.4-0.6-0.7-0.4-0.60.40.61.2-0.80.3-0.5-0.60.20.1
Social time0.50.71.10.70.81.00.7-0.8-0.9-0.90.7-1.00.80.9-0.9-0.7
Soleus weight0.00.00.20.10.20.1-0.00.1-0.20.30.10.10.20.3-0.1-0.4
Bone: stiffness0.10.31.20.4-0.1-1.10.3-0.7-0.40.3-0.2-0.6-0.5-0.7-0.30.1
Tibialis anterior weight0.41.42.1-1.3-1.2-0.7-1.41.21.30.2-1.31.3-1.3-1.01.41.4
Time to tail flick, vehicle, before self-admin0.10.10.6-0.2-0.2-0.4-0.10.20.00.8-0.10.2-0.1-0.20.1-0.0
Time to tail flick, vehicle, after self-admin0.20.41.20.70.60.10.9-0.6-0.50.10.7-0.60.60.3-0.8-1.1
Time to tail flick, test, before self-admin1.72.03.9-1.2-1.5-2.0-1.11.21.31.6-1.41.2-1.6-1.61.21.2
Time to tail flick, test, after self-admin1.21.32.31.11.20.81.2-1.0-1.1-1.51.4-1.01.21.3-0.8-0.7
Delta time to tail flick, vehicle, before/after SA0.30.30.60.70.50.30.7-0.6-0.4-0.40.5-0.50.50.4-0.6-0.7
Delta time to tail flick, test, before/after SA2.32.87.01.41.82.11.4-1.3-1.5-2.61.8-1.31.82.0-1.0-0.9
Tibia length0.00.10.60.1-0.2-0.60.00.10.1-0.5-0.1-0.1-0.3-0.30.40.7
Ambulatory time before self-admin1.34.05.3-2.1-2.1-2.1-2.11.92.11.4-2.01.9-2.1-1.92.12.3
Ambulatory time after self-admin0.10.21.40.40.40.20.4-0.5-0.4-1.20.4-0.50.30.4-0.20.1
Bone: tissue strength0.10.10.2-0.4-0.2-0.3-0.40.00.3-0.2-0.30.00.10.10.10.4
Total heroin consumption0.70.82.2-0.7-1.0-1.5-0.70.50.81.3-0.90.5-1.1-1.20.40.6
Bone: trabecular number2.14.05.72.02.22.42.0-1.7-2.0-2.32.2-1.52.12.4-1.4-1.7
Bone: trabecular spacing2.13.14.0-1.9-2.0-1.8-1.81.71.92.0-1.81.4-1.5-1.91.41.6
Bone: trabecular thickness3.04.25.52.32.21.82.2-2.1-2.3-2.22.2-2.01.71.9-1.7-1.6
Bone: trabecular tissue density1.12.04.2-1.0-1.5-2.0-1.01.21.21.8-1.50.9-1.7-1.81.01.3
Water consumed over 24 hours1.32.43.91.61.51.21.6-1.8-1.6-1.11.5-2.01.41.3-1.9-1.5
Number of responses in last shaping day1.11.42.5-1.5-1.2-0.6-1.61.51.31.1-1.21.4-0.8-0.71.21.0