Hub : Genes

Zfp423

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Zfp423 0.13 0.08 2.0e-05 0.07 0.1 0.07 0.08 7.2e-04 5.0e-05 3.8e-04 2.8e-04
2 PL mRNA stability Zfp423 0.13 0.08 2.0e-06 0.05 0.05 0.05 0.04 4.8e-06 7.0e-06 8.5e-06 1.1e-05
3 Brain gene expression Zfp423 0.24 0.12 0.0e+00 0.3 0.27 0.28 0.29 6.5e-28 5.8e-25 2.9e-26 2.3e-27
4 PL gene expression Zfp423 0.89 0 0.0e+00 0.21 0.2 0.2 0.2 9.1e-23 1.0e-21 4.8e-22 5.7e-22
5 Brain mRNA stability Zfp423 0.04 0.03 1.6e-03 0.04 0.02 0.03 0.03 1.6e-04 3.9e-03 1.4e-03 3.5e-04
6 OFC gene expression Zfp423 0.53 0.16 9.5e-13 0.42 0.38 0.38 0.4 5.3e-11 4.4e-10 4.7e-10 1.4e-10
7 OFC mRNA stability Zfp423 0.16 0.1 4.5e-04 0.14 0.13 0.07 0.13 4.4e-04 6.7e-04 9.8e-03 5.9e-04
8 Liver mRNA stability Zfp423 0.06 0.04 4.1e-07 0.06 0.05 0.06 0.06 3.7e-07 1.4e-06 4.3e-07 5.0e-07
9 IL gene expression Zfp423 0.27 0.12 4.2e-07 0.26 0.2 0.2 0.21 5.3e-07 1.6e-05 1.9e-05 7.4e-06
10 NAcc gene expression Zfp423 0.12 0.06 1.3e-12 0.09 0.09 0.09 0.09 1.1e-10 2.4e-10 2.9e-10 3.0e-10
11 LHb gene expression Zfp423 0.17 0.11 2.7e-03 0.1 0.02 0.08 0.09 2.2e-03 1.1e-01 6.4e-03 3.7e-03
12 BLA mRNA stability Zfp423 0.07 0.04 8.3e-04 0.04 0.06 0.04 0.05 2.1e-03 5.0e-04 3.3e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.62.73.3-1.71.81.71.61.71.51.51.81.71.41.8-1.6
Area under the delay curve0.10.10.40.30.4-0.2-0.40.5-0.50.6-0.0-0.3-0.50.10.2
BMI with tail1.44.76.72.5-1.8-2.4-2.3-1.7-2.3-1.1-2.3-2.3-2.6-2.02.4
BMI without tail0.00.00.2-0.10.1-0.00.10.40.10.30.20.2-0.10.40.1
Body weight0.73.15.11.7-2.1-1.4-1.4-2.0-1.5-2.3-1.7-1.4-1.6-2.01.9
Weight adjusted by age3.64.15.32.2-1.6-2.3-1.9-1.7-2.1-1.7-2.0-2.0-2.3-2.02.3
Bone surface1.11.92.7-1.41.61.31.41.61.11.41.61.31.01.6-1.2
Bone volume2.33.94.8-2.12.02.02.12.01.81.72.22.01.82.1-1.8
Breakpoint value in progressive ratio session1.21.35.0-0.1-2.20.40.4-1.90.6-2.0-0.30.50.7-1.10.1
Number of licking bursts0.50.50.8-0.70.80.60.50.70.90.70.70.70.80.7-0.8
Context. condit. distance diff. score3.33.95.22.3-1.6-2.0-2.0-1.6-2.3-1.7-2.1-2.1-2.3-2.01.6
Locomotion velocity, session 10.30.30.9-0.70.30.60.70.10.60.10.50.70.90.3-0.6
Locomotion distance, session 10.20.20.70.3-0.7-0.4-0.3-0.7-0.5-0.9-0.5-0.4-0.0-0.40.1
Locomotion velocity, session 20.00.00.20.0-0.1-0.1-0.1-0.1-0.3-0.4-0.1-0.10.2-0.1-0.1
Locomotion distance, session 20.60.92.90.8-1.2-0.8-0.7-1.1-0.6-1.7-0.9-0.7-0.5-1.00.6
Locomotion velocity, session 31.31.52.81.4-1.0-1.3-1.2-1.0-1.0-1.2-1.2-1.2-1.7-1.21.4
Locomotion distance, session 30.30.30.80.30.9-0.6-0.40.8-0.60.60.0-0.5-0.70.60.1
Stereotopy head waving bouts, day 30.30.31.00.7-0.1-0.7-0.70.0-0.4-0.1-0.5-0.7-1.0-0.30.6
Stereotopy head waving duration, day 30.70.91.71.1-0.7-1.0-1.1-0.6-0.7-0.3-1.0-1.0-1.3-0.91.0
Locomotion velocity, session 70.60.71.31.1-0.3-0.9-1.0-0.4-0.90.1-0.9-1.0-1.2-0.70.6
Locomotion distance, session 70.00.00.2-0.1-0.00.20.30.00.30.00.10.20.10.2-0.5
Stereotopy head waving bouts, day 70.30.30.90.40.9-0.4-0.50.9-0.60.70.0-0.4-0.90.40.3
Stereotopy head waving duration, day 70.81.02.6-0.71.60.60.51.60.41.31.00.60.31.2-0.6
Locomotion velocity, session 81.51.83.21.3-1.8-1.1-0.9-1.8-0.8-1.7-1.4-1.0-1.1-1.80.8
Locomotion distance, session 81.42.13.21.6-1.5-1.4-1.3-1.4-1.5-1.8-1.5-1.4-1.5-1.40.9
Degree of sensitization distance0.30.31.0-0.1-1.00.40.4-0.90.4-0.7-0.10.30.3-0.6-0.1
Degree of sensitization stereotypy0.30.30.80.50.6-0.5-0.60.5-0.90.2-0.2-0.5-0.80.20.5
Conditioned locomotion0.00.00.1-0.1-0.20.30.2-0.1-0.1-0.30.20.20.20.10.0
Cocaine response after cond. corrected3.74.26.31.9-2.5-2.1-1.7-2.5-1.9-1.9-2.2-1.9-1.6-2.31.8
Cocaine response after cond. not corrected3.13.55.81.7-2.4-1.8-1.5-2.4-1.7-1.9-2.0-1.6-1.3-2.11.7
Cocaine response before conditioning1.82.22.7-1.61.51.51.41.51.21.41.61.51.51.7-1.3
Saline control response0.91.12.0-1.10.21.31.30.31.2-0.11.01.31.40.6-1.4
Bone: connectivity density1.72.74.3-1.52.01.41.42.01.22.11.71.41.21.9-1.6
Bone: cortical apparent density0.30.41.40.21.2-0.1-0.41.2-0.31.10.2-0.3-0.70.6-0.2
Bone: cortical area0.20.30.5-0.60.40.70.70.40.60.20.60.60.30.6-0.5
Bone: cortical porosity0.10.10.20.1-0.5-0.00.1-0.5-0.1-0.5-0.1-0.0-0.2-0.20.2
Bone: cortical porosity0.10.10.2-0.30.10.40.50.10.20.20.40.40.00.4-0.2
Bone: cortical thickness0.00.00.2-0.00.20.20.10.20.10.40.20.1-0.30.10.0
Bone: cortical thickness0.10.10.40.3-0.50.0-0.1-0.5-0.2-0.2-0.3-0.1-0.3-0.60.2
Bone: cortical tissue density0.40.51.50.21.2-0.2-0.41.2-0.31.10.2-0.3-0.80.6-0.2
Condit. Reinf. active minus inactive responses0.80.81.80.80.9-1.1-1.20.8-1.40.9-0.4-1.0-1.10.50.3
Condit. Reinf. active-inactive response ratio1.11.22.51.3-0.4-1.5-1.5-0.5-1.6-0.3-1.1-1.4-1.2-0.60.8
Condit. Reinf. active responses1.01.23.6-0.51.90.30.21.80.01.90.90.3-0.01.6-0.7
Condit. Reinf. inactive responses6.07.18.4-2.72.82.72.72.82.62.82.92.72.02.9-2.4
Incentive salience index mean1.41.64.5-0.82.10.30.32.00.21.91.10.50.41.9-1.2
Condit. Reinf. lever presses3.34.47.0-2.02.61.51.62.51.62.32.21.71.82.6-2.1
Condit. Reinf. active minus inactive responses0.20.20.30.4-0.6-0.4-0.3-0.5-0.3-0.4-0.4-0.4-0.5-0.50.5
Condit. Reinf. active-inactive response ratio0.40.51.00.5-1.0-0.6-0.4-0.9-0.4-0.4-0.7-0.5-0.4-0.91.0
Condit. Reinf. active responses0.10.10.40.2-0.50.00.2-0.4-0.0-0.6-0.10.0-0.3-0.20.2
Condit. Reinf. inactive responses0.20.31.90.4-0.6-0.00.0-0.7-0.1-1.4-0.3-0.1-0.6-0.40.1
Condit. Reinf. lever presses0.60.81.21.0-1.0-0.7-0.8-0.9-1.1-1.0-0.9-0.9-1.0-0.80.9
Condit. Reinf. lever reinforcers received0.20.30.70.5-0.8-0.3-0.2-0.8-0.4-0.8-0.5-0.3-0.7-0.50.6
Conditioned reinforcement - actives1.11.12.01.1-1.2-0.9-0.9-1.4-1.0-0.9-1.1-1.0-1.0-1.11.0
Conditioned reinforcement - inactives1.01.11.71.2-0.8-1.3-1.2-1.1-0.9-1.1-1.2-1.3-1.1-0.90.6
Conditioned locomotion0.00.00.10.2-0.20.0-0.1-0.2-0.20.1-0.20.1-0.2-0.20.1
Patch foraging indifference point 0 sec0.30.41.00.9-0.3-0.6-0.8-0.3-0.7-0.3-0.7-0.7-1.0-0.50.4
Patch foraging indifference point AUC0.91.01.8-1.1-0.11.31.3-0.01.30.01.01.31.30.6-0.9
Delay disc. indifference point, 0s delay1.11.21.7-1.20.71.31.10.61.21.11.21.21.21.0-1.1
Delay disc. indifference point, 16s delay0.50.50.70.8-0.6-0.6-0.6-0.4-0.8-0.6-0.8-0.8-0.8-0.70.8
Delay disc. indifference point, 2s delay0.20.20.70.40.4-0.5-0.40.3-0.50.6-0.2-0.5-0.80.10.5
Delay disc. indifference point, 24s delay0.20.20.6-0.00.60.1-0.00.7-0.20.70.30.3-0.00.4-0.1
Delay disc. indifference point, 4s delay0.20.20.80.10.60.1-0.20.6-0.20.90.2-0.0-0.30.3-0.2
Delay disc. indifference point, 8s delay0.50.51.10.90.1-0.7-1.00.1-1.10.3-0.5-0.7-1.0-0.30.6
Indifference point function ln k0.91.32.41.30.0-1.5-1.50.0-1.50.2-1.1-1.5-1.6-0.51.0
Indifference point function log k0.91.32.41.30.0-1.5-1.50.0-1.50.2-1.1-1.5-1.6-0.51.0
Patch foraging total patch changes 0 sec0.40.71.41.0-0.6-0.8-0.9-0.6-0.9-0.6-0.9-0.9-1.2-0.70.6
Patch foraging total patch changes 12 sec0.30.41.0-0.60.10.70.80.40.70.00.50.70.70.5-1.0
Patch foraging total patch changes 18 sec1.31.73.0-1.40.51.71.60.41.50.71.41.61.51.0-1.5
Patch foraging total patch changes 24 sec0.70.91.6-0.90.51.21.10.60.90.51.01.10.80.9-1.3
Patch foraging total patch changes 6 sec0.10.20.5-0.40.30.70.50.40.50.10.50.50.40.4-0.6
Patch foraging time to switch 0 sec0.00.10.3-0.10.5-0.0-0.00.6-0.10.30.20.1-0.00.3-0.3
Patch foraging water rate 0 sec0.10.20.7-0.2-0.60.30.4-0.70.4-0.8-0.00.20.3-0.30.2
Patch foraging water rate 12 sec0.81.32.6-1.01.60.80.71.40.91.51.10.80.81.4-0.9
Patch foraging water rate 18 sec3.44.68.8-2.12.81.71.83.02.02.42.11.71.82.3-1.8
Patch foraging water rate 24 sec0.30.41.6-0.41.0-0.00.01.30.20.70.30.10.20.7-0.4
Patch foraging water rate 6 sec3.55.17.2-2.51.62.72.71.72.51.52.32.52.42.0-2.2
Seeking ratio, delayed vs. immediate footshock3.74.36.32.4-1.4-2.5-2.4-1.1-2.5-1.0-2.2-2.4-2.4-1.82.0
Distance traveled before self-admin1.51.62.61.2-1.6-1.2-1.2-1.5-1.2-1.2-1.2-0.9-1.0-1.31.5
Distance traveled after self-admin0.10.10.3-0.2-0.40.10.2-0.20.1-0.6-0.00.00.3-0.10.4
Extensor digitorum longus weight0.00.10.3-0.1-0.50.20.2-0.5-0.0-0.10.00.20.2-0.40.5
Bone: elastic displacement0.00.00.20.30.1-0.1-0.10.2-0.30.1-0.1-0.2-0.5-0.10.1
Bone: elastic work0.00.00.1-0.00.10.10.10.1-0.10.20.10.1-0.20.20.0
Bone: endosteal estimation0.30.52.70.4-1.0-0.4-0.3-1.0-0.3-1.6-0.6-0.4-0.2-0.80.4
Bone: endosteal perimeter0.20.52.10.5-0.9-0.4-0.3-0.9-0.4-1.5-0.6-0.4-0.3-0.60.3
Epididymis fat weight0.51.34.60.7-1.7-0.3-0.3-1.9-0.3-2.1-0.9-0.5-0.3-1.30.7
Delta time in closed arm before/after self-admin1.11.01.71.1-0.5-1.3-1.3-0.5-1.3-0.3-1.1-1.3-1.1-0.81.1
Delta time in open arm before/after self-admin1.71.63.5-1.3-0.51.71.7-0.41.7-0.51.21.91.60.4-1.1
Diff in mean of infusions in LGA sessions0.40.51.70.4-1.3-0.2-0.2-1.0-0.2-1.3-0.6-0.3-0.1-0.80.2
Delay discount exponential model param0.20.20.7-0.3-0.60.20.4-0.60.5-0.8-0.00.30.6-0.3-0.1
Extinction: sum of active levers before priming4.04.04.62.0-1.9-2.0-2.2-1.8-2.0-2.1-2.1-2.1-1.9-2.01.9
Active lever presses in extinction session 60.10.10.3-0.20.4-0.2-0.10.50.00.6-0.2-0.30.20.2-0.2
Bone: final force0.81.32.3-1.40.41.41.50.41.4-0.21.21.41.50.9-0.9
Bone: final moment0.50.81.4-1.10.31.11.20.31.1-0.30.91.11.20.7-0.7
Food consumed during 24 hour testing period4.65.69.4-2.71.32.72.71.33.00.72.42.73.11.8-2.6
Glucose0.40.61.4-0.80.21.01.00.21.20.30.81.00.70.4-0.6
Heart weight1.01.42.71.40.1-1.6-1.50.1-1.3-0.2-1.2-1.6-1.6-0.81.2
Delay discount hyperbolic model param0.20.20.9-0.3-0.70.20.4-0.70.5-0.9-0.00.30.6-0.3-0.1
Intermittent access intake day 1-15 change2.92.84.3-1.91.01.82.00.92.01.21.61.82.11.5-1.9
Intermittent access intake escalation4.44.36.5-2.31.32.32.41.12.41.42.12.22.61.9-2.3
Intermittent access intake escalation 23.23.14.6-1.91.51.71.81.31.91.71.71.71.91.8-2.2
Intermitt. access day 1 inactive lever presses0.20.20.50.30.4-0.4-0.60.6-0.50.7-0.2-0.4-0.40.2-0.1
Intermitt. access day 15 inactive lever presses0.90.91.21.0-1.0-1.1-1.0-1.0-0.9-1.0-1.1-1.0-0.8-1.10.6
Intermitt. access escalation Index0.30.30.7-0.60.20.50.60.10.70.30.80.60.60.5-0.6
Intermittent access day 1 total infusions3.54.04.62.1-1.9-2.0-2.0-1.9-2.0-1.8-1.9-2.0-2.1-2.12.1
Intermittent access day 15 total infusions0.10.10.60.1-0.6-0.10.0-0.80.0-0.4-0.2-0.10.0-0.40.2
Intermittent access terminal intake (last 3 days)0.40.41.30.6-1.0-0.5-0.4-1.1-0.4-0.7-0.5-0.4-0.4-0.70.5
Intermittent access total infusions0.50.51.40.6-1.0-0.6-0.5-1.2-0.5-0.9-0.6-0.6-0.5-0.80.6
Intermittent access day 1 locomotion0.50.51.10.8-0.6-0.8-0.8-0.5-0.8-0.5-0.6-0.7-0.9-0.61.0
Intermittent access day 15 total locomotion1.01.12.50.8-1.6-0.8-0.7-1.5-0.6-1.2-0.9-0.7-0.5-1.21.3
Intermittent access total locomotion1.01.23.00.8-1.7-0.8-0.8-1.6-0.6-1.3-0.8-0.6-0.6-1.21.3
Intermittent access standard deviation0.50.51.1-0.61.00.40.41.10.50.90.50.50.50.8-0.8
Left kidney weight0.10.20.5-0.40.30.70.50.70.4-0.40.40.40.50.1-0.3
Right kidney weight0.10.31.20.5-0.4-0.3-0.40.0-0.6-1.1-0.5-0.5-0.4-0.60.5
Cocaine induced anxiety0.80.91.51.2-0.8-0.9-1.0-0.9-1.1-0.8-1.0-0.9-1.1-0.90.4
Post-drug Anxiety0.50.60.80.9-0.6-0.8-0.9-0.6-0.8-0.6-0.9-0.8-0.8-0.80.5
Baseline Anxiety0.30.30.8-0.5-0.70.30.5-0.60.6-0.9-0.00.20.6-0.40.3
Tail length1.85.47.2-2.61.82.52.62.02.51.12.52.62.72.1-2.3
Length with tail0.10.41.9-0.4-0.60.60.6-0.50.4-1.40.20.60.8-0.4-0.2
Length without tail2.86.19.02.3-2.7-2.0-2.1-3.0-2.2-3.0-2.5-2.2-1.9-3.02.4
Times rat made contact with spout0.30.30.6-0.60.80.50.40.80.60.70.60.50.40.6-0.4
Lifetime Intake0.40.51.30.6-1.0-0.5-0.4-1.1-0.4-0.9-0.5-0.6-0.4-0.80.5
Liver weight, left0.30.52.10.4-1.1-0.3-0.1-1.1-0.5-1.5-0.6-0.3-0.2-0.90.2
Liver weight, right0.61.03.30.7-1.4-0.5-0.5-1.5-0.7-1.8-0.9-0.6-0.2-1.10.7
Locomotor activity0.20.41.60.4-1.00.0-0.1-0.60.1-1.3-0.3-0.1-0.4-0.70.6
Locomotor testing distance0.20.31.00.4-1.0-0.1-0.1-0.8-0.1-1.0-0.4-0.1-0.5-0.70.5
Locomotor testing rearing0.50.71.5-0.90.40.91.00.41.00.50.81.01.10.6-1.2
Locomotion in novel chamber0.70.92.30.8-1.3-0.7-0.6-0.7-0.5-1.5-1.1-0.9-0.8-1.10.8
Locomotion in novel chamber post-restriction0.30.31.0-0.50.80.40.30.70.31.00.50.20.50.7-0.4
Fecal boli incidents, locomotor time 10.60.71.6-0.90.11.11.30.10.80.10.81.01.00.5-1.0
Change in fecal boli incidents, locomotor task0.90.82.5-0.31.60.20.01.40.11.40.90.5-0.01.2-0.7
Time >=10cm from walls, locomotor time 10.30.30.6-0.50.70.40.50.50.30.60.80.70.40.7-0.2
Bouts of movement, locomotor time 11.01.12.0-1.01.40.80.91.40.91.30.70.50.91.1-1.2
Total resting periods, locomotor time 10.70.71.9-0.71.40.40.51.30.51.30.40.10.60.9-0.9
Rest time, locomotor task time 10.60.61.6-0.71.30.30.61.20.51.20.3-0.10.60.9-0.7
Distance moved, locomotor task time 11.01.12.21.0-1.5-0.7-0.9-1.4-0.9-1.4-0.8-0.4-0.9-1.11.1
Vertical activity count, locomotor time 10.60.61.4-0.5-1.01.00.8-1.10.8-0.80.61.20.7-0.1-0.3
Time >=10cm from walls, locomotor time 20.60.61.10.7-0.9-0.6-0.6-1.0-0.8-1.1-0.6-0.4-0.4-0.81.1
Bouts of movement, locomotor time 20.20.20.60.20.7-0.2-0.40.7-0.40.80.2-0.1-0.40.40.1
Total resting periods, locomotor time 20.20.20.7-0.10.80.2-0.10.8-0.10.90.50.2-0.10.6-0.3
Rest time, locomotor task time 20.20.20.4-0.40.40.40.60.50.40.50.20.00.30.4-0.6
Distance moved, locomotor task time 22.12.43.21.6-1.6-1.6-1.7-1.6-1.4-1.7-1.6-1.3-1.2-1.61.8
Vertical activity count, locomotor time 20.30.31.2-0.2-0.90.50.4-1.10.5-0.70.10.60.4-0.30.0
Light reinforcement 113.524.632.3-5.53.55.75.73.85.43.15.25.65.44.4-5.3
Light reinforcement 210.514.121.1-4.22.34.44.62.54.22.23.94.34.33.1-3.9
Bone: marrow area0.30.62.70.5-1.1-0.5-0.3-1.1-0.4-1.7-0.6-0.4-0.2-0.80.5
Bone: maximum diameter0.10.20.40.5-0.3-0.4-0.5-0.3-0.6-0.5-0.4-0.5-0.6-0.20.4
Bone: maximum force0.10.20.5-0.6-0.20.50.6-0.20.7-0.60.40.50.70.2-0.3
Bone: maximum moment0.10.10.5-0.3-0.30.30.4-0.30.4-0.70.20.30.50.0-0.1
Mean time between licks in bursts0.20.30.70.30.8-0.4-0.30.8-0.70.60.0-0.4-0.70.5-0.1
Mean num. licks in bursts0.10.10.30.30.1-0.3-0.20.2-0.50.2-0.2-0.3-0.5-0.10.4
Cd content in liver0.40.41.30.70.1-0.9-1.10.1-1.10.2-0.6-0.9-0.4-0.20.1
Co content in liver0.40.51.60.50.6-0.6-0.80.6-0.91.3-0.3-0.7-0.50.10.4
Cu content in liver0.10.10.40.4-0.1-0.5-0.6-0.0-0.4-0.2-0.3-0.5-0.40.10.4
Fe content in liver0.30.30.5-0.70.70.40.50.70.30.30.60.50.70.7-0.1
K content in liver0.30.30.60.4-0.6-0.4-0.4-0.6-0.4-0.8-0.4-0.4-0.4-0.40.7
Mg content in liver0.80.81.21.0-0.8-0.9-0.9-0.8-1.0-0.8-0.8-0.9-1.1-0.61.1
Mn content in liver1.92.12.81.5-1.6-1.2-1.2-1.7-1.3-1.6-1.5-1.3-1.5-1.61.5
Na content in liver0.30.32.8-0.0-0.60.00.1-0.50.0-1.7-0.10.00.2-0.40.4
Rb content in liver0.91.11.8-1.01.20.90.81.21.21.31.10.90.81.2-0.8
Se content in liver1.62.02.8-1.71.21.51.51.21.31.01.51.51.71.3-1.2
Sr content in liver0.10.10.70.1-0.3-0.1-0.2-0.30.1-0.8-0.2-0.10.2-0.20.1
Zn content in liver3.23.64.42.1-1.8-2.0-2.1-1.7-1.7-1.6-2.0-2.0-2.0-1.81.8
Bone: minimum diameter0.61.11.7-1.20.51.21.30.51.3-0.31.11.21.30.8-1.0
Time in familiar zone, hab. session 11.11.02.2-0.91.50.70.61.30.61.31.00.70.91.1-1.1
Time in novel zone, hab. session 10.70.71.10.8-0.9-0.8-0.7-0.7-0.6-0.8-0.8-0.8-0.9-0.71.1
Total zone transitions, hab. session 10.30.41.00.6-1.0-0.4-0.4-0.9-0.4-0.8-0.6-0.4-0.4-0.70.5
Total locomotion distance, hab. session 10.91.32.41.1-1.5-0.9-0.9-1.4-1.0-1.5-1.1-0.9-0.9-1.21.0
Locomotion velocity, hab. session 10.81.22.41.0-1.5-0.7-0.7-1.4-0.9-1.6-1.0-0.7-0.9-1.10.9
Time in familiar zone, hab. session 21.81.93.0-1.41.31.31.41.41.41.31.41.41.21.4-1.7
Time in novel zone, hab. session 24.64.66.22.2-2.1-2.1-2.2-2.1-2.1-1.9-2.2-2.2-2.0-2.12.5
Total zone transitions, hab. session 20.10.10.2-0.10.20.10.20.3-0.00.40.30.20.20.4-0.3
Total locomotion distance, hab. session 20.20.30.80.4-0.9-0.1-0.1-0.8-0.5-0.7-0.3-0.2-0.3-0.50.4
Locomotion velocity, hab. session 20.10.20.70.1-0.80.10.1-0.7-0.3-0.8-0.10.10.0-0.30.2
Novel to familiar place preference ratio1.61.62.91.3-1.0-1.3-1.3-0.8-1.4-1.7-1.3-1.4-1.2-1.11.3
Novelty place preference1.51.53.11.2-1.1-1.2-1.2-1.0-1.2-1.7-1.3-1.3-1.0-1.21.3
Time in novel zone, NPP test1.11.11.81.0-0.8-1.1-1.1-0.7-1.1-1.4-1.1-1.1-0.9-0.91.2
Total zone transitions, NPP test0.10.10.30.1-0.50.10.1-0.6-0.1-0.5-0.10.1-0.2-0.30.1
Total locomotion distance, NPP test0.10.10.30.4-0.5-0.2-0.2-0.4-0.4-0.5-0.2-0.2-0.5-0.30.5
Locomotion velocity, NPP test0.10.20.70.3-0.7-0.00.0-0.6-0.3-0.9-0.2-0.0-0.3-0.40.3
Intraocular pressure4.76.58.42.9-1.8-2.8-2.9-1.9-2.6-2.1-2.7-2.9-2.9-2.32.6
Delta distance traveled before/after self-admin1.01.01.4-1.11.01.11.21.01.10.61.00.81.11.0-1.0
Delta ambulatory time before/after self-admin2.02.12.7-1.61.71.51.61.51.51.11.41.21.51.5-1.5
Parametrial fat weight0.10.10.60.2-0.50.10.2-0.10.0-0.8-0.20.0-0.1-0.5-0.0
Pavlov. Cond. lever latency0.00.00.20.1-0.40.10.0-0.40.3-0.2-0.1-0.00.0-0.2-0.0
Pavlov. Cond. magazine entry latency0.10.10.30.30.2-0.5-0.50.2-0.10.3-0.3-0.5-0.4-0.10.4
Pavlov. Cond. change in total contacts1.01.01.5-1.11.10.90.91.21.00.71.01.01.11.1-0.8
Pavlov. Cond. index score0.10.10.30.30.2-0.5-0.50.3-0.30.1-0.3-0.4-0.40.00.4
Pavlov. Cond. latency score0.10.10.30.30.1-0.5-0.50.1-0.4-0.1-0.3-0.4-0.3-0.10.3
Pavlov. Cond. lever contacts0.00.00.1-0.20.30.10.10.40.1-0.20.20.10.00.20.1
Pavlov. Cond. magazine entry number0.10.10.40.0-0.60.30.2-0.7-0.1-0.6-0.10.10.1-0.3-0.2
Pavlov. Cond. intertrial magazine entries0.00.10.40.10.20.1-0.00.1-0.00.10.10.0-0.60.3-0.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.5-0.1-0.7-0.7-0.0-0.4-0.2-0.5-0.6-0.5-0.30.6
Pavlov. Cond. response bias0.10.10.5-0.10.6-0.1-0.10.70.10.70.2-0.0-0.20.40.3
Pavlov. Cond. lever latency0.60.81.20.8-1.0-1.0-0.8-1.0-0.6-1.1-0.9-0.8-0.7-1.00.9
Pavlov. Cond. magazine entry latency0.00.00.1-0.20.10.10.20.10.10.30.10.10.20.1-0.3
Pavlov. Cond. change in total contacts0.20.31.5-0.30.70.40.20.8-0.21.20.40.20.30.6-0.3
Pavlov. Cond. index score0.10.10.3-0.30.40.30.30.5-0.00.60.30.20.20.4-0.3
Pavlov. Cond. latency score0.10.10.4-0.20.30.20.20.3-0.00.60.20.10.20.3-0.2
Pavlov. Cond. lever contacts0.91.21.5-1.11.11.21.11.20.81.11.11.11.01.2-1.2
Pavlov. Cond. magazine entry number0.00.00.1-0.10.20.20.00.20.4-0.10.20.20.10.1-0.1
Pavlov. Cond. intertrial magazine entries0.70.91.6-0.90.81.10.90.81.30.11.01.10.70.9-1.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.30.50.20.20.5-0.10.60.20.10.20.4-0.3
Pavlov. Cond. response bias0.20.30.5-0.60.50.70.60.50.40.50.60.60.60.6-0.6
Time in closed arm before self-admin5.15.89.3-2.43.12.12.22.72.22.72.31.82.02.7-2.3
Time in closed arm after self-admin1.21.23.0-1.01.70.70.71.50.91.70.80.40.81.3-0.8
Time in open arm before self-admin3.13.34.52.0-1.7-2.0-2.0-1.3-2.1-1.3-2.0-1.9-1.8-1.91.8
Time in open arm after self-admin1.31.43.51.1-1.9-0.8-0.8-1.5-0.9-1.8-0.9-0.5-0.8-1.41.1
Bone: periosteal estimation0.10.11.0-0.2-0.40.30.3-0.40.3-1.00.10.30.2-0.0-0.1
Bone: periosteal perimeter0.00.10.30.2-0.2-0.1-0.0-0.2-0.1-0.6-0.1-0.1-0.40.00.0
Bone: post-yield work0.10.21.0-0.1-0.5-0.20.0-0.50.2-1.0-0.2-0.00.4-0.4-0.0
Progressive ratio test 1 active lever presses2.02.13.21.4-1.7-1.3-1.2-1.8-1.2-1.7-1.2-1.2-1.2-1.51.7
Progressive ratio test 1 breakpoint1.31.42.21.1-1.4-1.1-1.0-1.5-1.0-1.4-0.9-1.0-1.0-1.21.4
Progressive ratio test 1 inactive lever presses0.10.10.20.4-0.2-0.3-0.4-0.4-0.3-0.2-0.1-0.2-0.3-0.30.3
Progressive ratio test 2 active lever presses0.70.81.60.9-0.8-1.0-0.7-1.3-0.8-0.4-0.9-0.9-0.7-0.91.0
Progressive ratio test 2 breakpoint1.01.12.41.0-1.1-1.1-0.8-1.5-0.9-0.7-1.0-1.0-0.8-1.11.1
Progressive ratio test 2 inactive lever presses2.93.34.11.9-1.8-1.9-1.8-2.0-1.7-1.5-1.9-1.8-1.7-1.91.7
Incentive Sensitization - Responses0.10.10.50.20.3-0.3-0.1-0.3-0.20.7-0.0-0.3-0.00.0-0.0
Incentive Sensitization - Breakpoint0.10.10.60.10.3-0.20.0-0.2-0.10.80.1-0.20.10.1-0.1
Sum of active levers in priming session hrs 5-60.20.20.60.0-0.8-0.10.0-0.70.1-0.8-0.3-0.10.2-0.4-0.1
Progressive ratio0.10.10.2-0.3-0.00.50.5-0.10.40.10.30.50.30.3-0.2
Food seeking constrained by brief footshock2.63.23.9-1.91.62.01.91.41.91.31.81.72.01.7-2.0
Seeking ratio, punishment vs. effort0.81.01.4-1.11.11.01.01.11.00.81.00.91.21.0-1.1
Retroperitoneal fat weight1.13.710.21.7-2.5-1.2-1.2-2.6-1.3-3.2-1.8-1.4-1.3-2.21.4
Reaction time number correct0.50.81.81.0-0.1-1.0-1.2-0.4-0.90.4-0.8-1.0-1.3-0.51.0
Reaction time mean minus median0.91.21.91.1-1.1-1.0-0.9-1.0-1.2-1.0-1.0-1.0-1.1-1.01.4
Reaction time mean minus median AUC1.62.02.61.4-1.6-1.3-1.2-1.5-1.5-1.6-1.4-1.3-1.2-1.51.6
Reaction time num false alarms4.15.57.32.6-1.9-2.5-2.7-1.9-2.7-1.4-2.5-2.6-2.6-2.22.2
Reaction time num false alarms AUC3.04.16.12.4-1.3-2.3-2.5-1.3-2.4-0.9-2.2-2.4-2.4-1.81.8
Reaction time trials correct on left0.50.81.81.0-0.1-1.0-1.2-0.4-0.90.4-0.8-1.0-1.3-0.51.0
Reaction time trials on left0.70.92.11.1-0.2-1.1-1.3-0.5-1.00.2-0.9-1.1-1.4-0.61.1
Reaction time mean3.75.16.42.3-1.8-2.5-2.4-1.8-2.5-2.1-2.4-2.5-2.0-2.22.5
Reaction time mean AUC4.05.46.72.3-1.9-2.6-2.5-1.8-2.6-2.1-2.5-2.6-2.0-2.32.5
Median of all reaction times3.65.06.62.2-1.7-2.5-2.4-1.6-2.5-2.0-2.4-2.6-1.9-2.22.3
Reaction time omissions2.33.24.11.8-1.6-1.7-1.7-1.7-2.0-1.7-1.8-1.8-1.8-2.01.9
Reaction time false alarm rate1.21.62.41.4-1.0-1.4-1.5-0.8-1.6-1.0-1.4-1.4-1.3-1.31.0
Reaction time premature initiation rate3.85.17.6-2.41.82.42.51.92.21.62.42.42.42.1-2.8
Reaction time premature initiations1.52.23.3-1.51.31.51.51.21.41.31.61.51.31.5-1.8
Std. dev. reaction times1.72.32.91.5-1.6-1.5-1.4-1.6-1.6-1.6-1.5-1.5-1.3-1.61.7
Reaction time trials completed0.70.92.11.1-0.2-1.1-1.3-0.5-1.00.2-0.9-1.1-1.4-0.61.1
Reaction time trials AUC0.71.02.11.1-0.3-1.1-1.3-0.6-1.00.2-0.9-1.1-1.5-0.61.1
Run reversals in cocaine runway, females2.82.75.91.4-2.3-1.0-1.1-2.4-1.1-2.2-1.5-1.0-0.9-2.01.7
Run reversals in cocaine runway, males0.10.10.20.20.3-0.4-0.4-0.1-0.30.1-0.0-0.1-0.2-0.00.3
Latency to leave start box in cocaine runway1.11.23.70.8-1.7-0.6-0.7-1.6-0.6-1.9-0.9-0.6-0.4-1.30.9
Latency to leave start box in cocaine runway, F1.82.03.61.1-1.8-1.0-1.1-1.9-0.9-1.9-1.4-1.1-0.8-1.61.5
Latency to leave start box in cocaine runway, M0.80.81.5-0.9-0.21.11.00.01.0-0.60.91.21.20.4-1.2
Std. dev. time between licks in bursts0.60.71.4-0.71.10.80.81.20.50.90.90.70.31.1-0.9
Total sessions with >9 infusions0.60.60.90.9-0.6-1.0-0.9-0.7-0.9-0.6-0.8-0.9-0.8-0.60.8
Short access day 1 total inactive lever presses0.20.20.4-0.4-0.40.60.6-0.30.6-0.40.60.60.50.2-0.4
Short access day 10 total inactive lever presses0.80.91.9-0.81.20.70.61.40.71.10.70.60.71.0-1.3
Short access day 1 total infusions1.71.82.11.5-1.3-1.5-1.4-1.4-1.4-1.1-1.2-1.5-1.4-1.21.4
Short access day 10 total infusions0.50.61.70.6-1.2-0.4-0.3-1.3-0.4-1.1-0.4-0.4-0.4-0.90.6
Short access total infusions0.20.30.90.4-0.8-0.3-0.2-0.9-0.2-0.8-0.3-0.3-0.2-0.50.4
Short access day 1 locomotion2.42.53.11.6-1.7-1.6-1.3-1.8-1.6-1.6-1.6-1.4-1.5-1.61.7
Short access day 10 total locomotion0.20.30.50.5-0.4-0.7-0.7-0.2-0.6-0.1-0.5-0.6-0.5-0.30.5
Short access total locomotion1.01.11.51.1-1.0-1.2-1.1-0.8-1.1-0.6-1.1-1.2-1.0-0.81.1
One hour access (0.3 mA shock)0.20.30.90.4-0.7-0.4-0.2-0.9-0.2-0.5-0.6-0.6-0.1-0.60.0
Compulsive drug intake2.32.35.2-1.32.21.00.92.31.02.01.40.91.01.8-1.5
One hour access (shock baseline)1.82.14.81.3-1.9-1.2-1.0-2.2-1.0-1.7-1.5-1.3-1.1-1.61.2
Social response proportion0.60.61.00.6-0.8-0.8-0.5-0.8-1.0-0.8-0.8-0.8-0.5-1.00.8
Social responses0.30.41.00.7-0.5-0.6-0.6-0.3-1.0-0.4-0.7-0.7-0.4-0.70.2
Social time0.50.71.3-0.81.00.80.71.10.41.00.70.70.90.8-0.8
Soleus weight0.00.00.10.00.00.00.10.0-0.00.00.10.1-0.20.1-0.2
Bone: stiffness0.30.41.2-0.5-0.90.50.6-0.80.8-1.10.10.50.7-0.30.0
Tibialis anterior weight0.51.72.81.4-0.8-1.5-1.4-0.8-1.6-0.5-1.3-1.4-1.7-1.11.5
Time to tail flick, vehicle, before self-admin0.00.00.1-0.0-0.30.20.0-0.10.3-0.3-0.00.20.2-0.1-0.2
Time to tail flick, vehicle, after self-admin0.50.51.2-0.6-0.31.00.9-0.20.7-0.50.81.10.90.3-0.8
Time to tail flick, test, before self-admin1.00.92.30.9-1.5-0.7-0.7-1.2-0.8-1.2-0.9-0.7-0.7-1.10.9
Time to tail flick, test, after self-admin0.70.71.4-0.80.51.10.80.50.91.01.01.20.70.9-0.7
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.50.20.70.80.10.5-0.00.70.80.60.5-0.6
Delta time to tail flick, test, before/after SA1.31.12.3-1.11.31.00.81.11.01.51.11.00.81.2-0.7
Tibia length0.00.10.3-0.1-0.40.10.1-0.40.1-0.50.00.10.2-0.10.5
Ambulatory time before self-admin2.42.54.91.4-2.2-1.3-1.3-2.1-1.3-1.8-1.5-1.1-1.2-1.71.8
Ambulatory time after self-admin0.30.30.8-0.8-0.10.70.80.00.8-0.30.50.60.90.3-0.3
Bone: tissue strength0.00.00.1-0.0-0.0-0.2-0.1-0.0-0.0-0.3-0.0-0.10.20.30.1
Total heroin consumption0.91.13.50.5-1.8-0.4-0.4-1.6-0.3-1.9-0.8-0.40.0-1.30.6
Bone: trabecular number2.23.45.1-1.72.31.71.62.21.52.12.01.61.22.2-1.6
Bone: trabecular spacing2.43.13.81.7-1.9-1.7-1.8-1.8-1.8-1.9-1.8-1.7-1.3-1.81.6
Bone: trabecular thickness2.83.45.0-2.11.52.12.11.52.21.42.02.01.91.6-1.5
Bone: trabecular tissue density1.01.54.60.9-1.6-0.7-0.8-1.5-0.5-2.1-1.1-0.8-0.6-1.51.2
Water consumed over 24 hours2.42.95.0-1.91.21.81.91.22.21.21.71.82.11.4-1.8
Number of responses in last shaping day4.95.16.72.5-1.8-2.5-2.4-1.8-2.3-1.9-2.3-2.6-2.3-2.22.1