Hub : Genes

Zbtb45

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC alternative TSS XM_006228115.5 0.36 0.21 6.9e-03 0.01 0.04 0.02 0.01 1.7e-01 3.8e-02 1.1e-01 1.5e-01
2 PL intron excision ratio chr1_82710277_82711694 0.04 0.03 5.1e-04 0.01 0.02 0.02 0.02 1.9e-02 1.3e-03 1.1e-03 2.0e-03
3 NAcc intron excision ratio chr1_82710277_82711694 0.09 0.05 7.9e-06 0.04 0.04 0.04 0.04 1.1e-06 2.4e-06 1.4e-06 2.1e-06
4 NAcc intron excision ratio chr1_82710277_82711564 0.11 0.06 2.9e-07 0.05 0.04 0.05 0.05 3.8e-08 2.1e-07 1.4e-07 3.9e-08
5 Liver isoform ratio XM_006228114.5 0.02 0.01 3.7e-03 0.02 0.02 0.02 0.02 2.6e-03 3.4e-03 6.4e-03 3.3e-03
6 Liver isoform ratio NM_001107478.1 0.05 0.03 3.8e-07 0.05 0.06 0.05 0.05 4.4e-06 5.9e-07 2.8e-06 5.1e-06
7 Liver alternative TSS XM_006228115.5 0.04 0.03 1.2e-05 0.03 0.04 0.04 0.04 5.1e-04 8.5e-06 3.9e-05 2.2e-05
8 Liver alternative TSS NM_001107478.1 0.04 0.02 1.9e-05 0.03 0.04 0.04 0.04 8.1e-04 1.4e-05 8.5e-05 4.4e-05
9 BLA gene expression Zbtb45 0.14 0.09 9.0e-06 0.1 0.08 0.1 0.1 9.5e-06 4.6e-05 8.0e-06 1.0e-05
10 Brain gene expression Zbtb45 0.09 0.07 2.4e-07 0.08 0.07 0.07 0.08 1.1e-07 2.2e-07 1.6e-07 1.3e-07
11 NAcc gene expression Zbtb45 0.09 0.05 5.4e-14 0.09 0.08 0.09 0.09 7.3e-14 1.1e-12 7.5e-13 2.9e-13
12 PL gene expression Zbtb45 0.22 0.1 0.0e+00 0.17 0.16 0.17 0.17 1.4e-18 1.6e-17 2.6e-18 2.0e-18
13 Liver mRNA stability Zbtb45 0.09 0.05 5.9e-11 0.08 0.09 0.09 0.07 5.8e-09 9.6e-10 9.0e-10 1.2e-08
14 IC gene expression Zbtb45 0.31 0.14 1.0e-05 0.14 0.11 0.11 0.13 1.2e-06 3.4e-05 1.9e-05 4.8e-06
15 pVTA gene expression Zbtb45 0.06 0.05 7.7e-03 0 0.01 0.01 -0 1.3e-01 5.1e-02 2.3e-02 3.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.20.50.3-0.5-0.40.3-0.10.5-0.50.50.50.40.50.50.30.60.7
Area under the delay curve0.91.01.7-1.01.30.9-0.80.5-0.90.8-0.8-1.1-1.3-1.2-1.2-0.6-1.1-1.3
BMI with tail0.62.23.9-0.50.8-1.21.21.6-1.61.7-1.7-1.5-1.6-1.6-1.6-2.0-1.3-1.5
BMI without tail0.30.94.41.0-0.6-2.11.90.0-0.40.5-0.6-0.5-0.7-0.7-0.7-0.9-0.5-0.9
Body weight1.04.314.63.2-2.9-3.83.6-1.81.5-1.31.31.41.21.11.10.81.30.9
Weight adjusted by age0.50.81.71.2-1.1-1.30.8-1.11.0-0.90.90.60.50.60.60.90.60.9
Bone surface3.46.28.32.7-2.9-2.12.0-2.02.5-2.42.42.62.62.62.62.02.72.8
Bone volume2.84.96.42.3-2.5-1.71.6-1.82.3-2.22.22.42.32.42.41.92.52.4
Breakpoint value in progressive ratio session2.02.44.2-1.71.72.1-2.00.7-1.41.3-1.3-1.4-1.5-1.6-1.6-0.8-1.5-2.0
Number of licking bursts0.10.21.30.5-0.2-1.11.10.1-0.20.3-0.3-0.3-0.3-0.3-0.3-0.5-0.3-0.2
Context. condit. distance diff. score0.00.00.20.2-0.4-0.40.4-0.10.1-0.10.1-0.00.00.00.0-0.00.00.3
Locomotion velocity, session 10.50.51.10.3-0.40.4-0.4-1.10.9-0.90.90.60.80.70.71.10.30.7
Locomotion distance, session 12.43.15.71.8-1.8-0.60.6-2.42.1-2.12.11.71.81.71.72.11.31.4
Locomotion velocity, session 20.30.31.10.7-0.7-1.01.1-0.30.5-0.40.30.30.40.40.40.20.10.5
Locomotion distance, session 22.02.84.22.0-2.0-1.51.6-1.61.8-1.71.71.71.71.61.61.41.51.5
Locomotion velocity, session 30.10.10.20.3-0.5-0.50.50.10.2-0.10.10.30.50.50.5-0.00.30.3
Locomotion distance, session 31.01.12.30.7-1.1-0.40.4-0.61.1-1.01.01.11.21.31.30.91.21.5
Stereotopy head waving bouts, day 30.30.31.2-0.20.50.1-0.10.1-0.60.6-0.6-0.6-0.5-0.6-0.6-0.5-0.9-1.1
Stereotopy head waving duration, day 30.40.41.7-0.30.60.4-0.40.0-0.60.6-0.6-0.6-0.6-0.7-0.7-0.4-1.1-1.3
Locomotion velocity, session 70.40.41.2-0.1-0.11.0-1.1-0.60.5-0.60.60.60.50.50.50.90.30.3
Locomotion distance, session 70.10.10.20.1-0.20.2-0.2-0.40.3-0.40.40.30.20.20.20.40.2-0.0
Stereotopy head waving bouts, day 70.40.40.80.7-0.9-0.90.8-0.30.5-0.40.40.70.80.80.80.30.50.8
Stereotopy head waving duration, day 70.20.30.60.6-0.7-0.80.7-0.40.4-0.30.30.50.50.60.60.20.30.5
Locomotion velocity, session 80.10.10.30.3-0.3-0.0-0.0-0.50.4-0.40.40.10.10.10.10.40.10.3
Locomotion distance, session 80.50.71.10.9-1.1-0.70.8-0.80.9-0.80.80.70.80.80.80.70.71.0
Degree of sensitization distance0.30.31.3-0.20.60.3-0.3-0.1-0.40.4-0.4-0.5-0.6-0.7-0.7-0.2-0.8-1.1
Degree of sensitization stereotypy0.60.71.80.7-1.1-1.31.20.10.5-0.40.40.70.80.90.90.10.81.4
Conditioned locomotion0.00.00.10.2-0.2-0.20.3-0.30.1-0.10.1-0.2-0.1-0.2-0.20.1-0.3-0.2
Cocaine response after cond. corrected0.70.92.4-1.00.90.5-0.51.5-1.21.2-1.2-0.7-0.6-0.6-0.6-1.2-0.7-0.9
Cocaine response after cond. not corrected0.20.20.60.6-0.6-0.70.70.00.2-0.20.20.50.50.50.5-0.00.40.2
Cocaine response before conditioning5.87.011.93.5-3.2-3.03.0-3.02.8-2.62.62.32.22.22.22.22.22.3
Saline control response1.11.43.61.5-1.5-1.91.9-0.81.1-0.90.90.90.91.01.00.50.91.2
Bone: connectivity density0.10.10.5-0.1-0.2-0.40.40.60.1-0.00.00.20.30.40.4-0.20.20.7
Bone: cortical apparent density0.10.20.6-0.40.60.7-0.80.1-0.30.2-0.2-0.3-0.4-0.4-0.4-0.1-0.4-0.7
Bone: cortical area0.81.22.31.5-1.3-1.51.5-1.11.2-1.11.00.80.80.80.80.80.81.0
Bone: cortical porosity0.30.30.5-0.30.2-0.20.20.7-0.60.7-0.7-0.6-0.5-0.6-0.6-0.7-0.5-0.6
Bone: cortical porosity0.20.20.40.1-0.1-0.60.60.6-0.40.5-0.5-0.2-0.1-0.3-0.3-0.6-0.2-0.3
Bone: cortical thickness0.30.61.0-0.60.80.2-0.20.5-0.60.7-0.7-0.9-0.9-1.0-1.0-0.6-1.0-1.0
Bone: cortical thickness0.20.20.70.7-0.6-0.80.8-0.40.4-0.30.30.40.30.30.30.20.40.2
Bone: cortical tissue density0.20.20.8-0.50.60.8-0.90.1-0.30.2-0.2-0.3-0.3-0.4-0.4-0.1-0.3-0.7
Condit. Reinf. active minus inactive responses0.20.20.50.2-0.0-0.60.60.1-0.40.4-0.4-0.3-0.4-0.4-0.4-0.5-0.3-0.7
Condit. Reinf. active-inactive response ratio1.11.21.9-0.50.8-0.40.41.0-1.21.2-1.2-1.2-1.3-1.3-1.3-1.3-1.2-1.4
Condit. Reinf. active responses0.20.30.70.8-0.8-0.70.7-0.50.4-0.40.40.60.60.50.50.30.50.2
Condit. Reinf. inactive responses2.32.83.91.4-1.7-0.20.2-1.81.8-1.81.81.92.01.91.91.81.71.8
Incentive salience index mean0.20.30.90.9-0.7-0.90.9-0.60.3-0.30.30.30.10.10.10.20.2-0.2
Condit. Reinf. lever presses0.50.71.61.3-1.1-1.01.0-1.20.9-0.80.80.70.50.50.50.80.60.3
Condit. Reinf. active minus inactive responses2.93.84.91.8-2.0-0.60.5-2.22.2-2.22.22.12.02.02.02.22.12.1
Condit. Reinf. active-inactive response ratio3.13.64.71.7-1.9-0.60.5-2.02.1-2.12.12.22.12.12.12.12.02.0
Condit. Reinf. active responses2.73.75.51.8-2.0-0.70.6-2.32.3-2.22.21.91.81.81.82.22.02.1
Condit. Reinf. inactive responses0.10.10.40.3-0.2-0.10.2-0.60.4-0.30.3-0.1-0.2-0.2-0.20.40.20.2
Condit. Reinf. lever presses0.10.20.60.5-0.5-0.80.7-0.30.4-0.30.30.10.00.10.10.20.20.4
Condit. Reinf. lever reinforcers received3.65.06.72.2-2.4-1.00.9-2.52.6-2.52.52.22.12.22.22.52.42.5
Conditioned reinforcement - actives0.20.31.10.9-0.8-1.01.1-0.2-0.10.2-0.20.20.20.10.1-0.4-0.1-0.6
Conditioned reinforcement - inactives1.01.54.01.7-1.5-0.81.2-2.01.3-1.31.31.11.00.90.91.20.90.6
Conditioned locomotion0.10.10.60.2-0.1-0.10.7-0.1-0.30.3-0.3-0.1-0.0-0.2-0.2-0.4-0.3-0.7
Patch foraging indifference point 0 sec0.30.61.6-0.60.6-0.0-0.10.2-0.60.7-0.7-1.2-0.9-1.0-1.0-0.5-1.3-1.1
Patch foraging indifference point AUC0.71.03.20.20.0-1.81.81.1-0.91.0-1.0-0.7-0.6-0.5-0.5-1.5-0.7-0.4
Delay disc. indifference point, 0s delay0.20.20.60.2-0.00.0-0.1-0.70.7-0.60.60.0-0.0-0.0-0.00.80.10.4
Delay disc. indifference point, 16s delay1.51.62.6-1.51.61.2-1.21.4-1.51.4-1.4-1.0-0.9-0.9-0.9-1.2-0.9-1.4
Delay disc. indifference point, 2s delay0.50.61.4-0.70.80.8-0.60.1-0.50.4-0.4-0.8-1.2-1.0-1.0-0.2-0.8-1.1
Delay disc. indifference point, 24s delay0.80.91.7-0.70.90.1-0.11.1-1.21.2-1.2-0.9-0.9-1.0-1.0-1.1-0.9-1.3
Delay disc. indifference point, 4s delay0.10.10.20.4-0.1-0.30.4-0.30.3-0.30.30.20.10.20.20.30.40.3
Delay disc. indifference point, 8s delay1.11.32.4-1.21.31.3-1.40.4-0.90.8-0.8-1.2-1.4-1.3-1.3-0.5-1.3-1.5
Indifference point function ln k3.25.512.41.8-2.00.8-0.8-3.52.8-3.03.02.32.11.91.93.42.01.8
Indifference point function log k3.25.512.41.8-2.00.8-0.8-3.52.8-3.03.02.32.11.91.93.42.01.8
Patch foraging total patch changes 0 sec0.40.71.9-0.50.7-0.1-0.10.2-0.70.8-0.8-1.2-1.0-1.1-1.1-0.6-1.4-1.2
Patch foraging total patch changes 12 sec0.40.61.4-0.10.2-1.21.11.0-0.80.9-0.9-0.7-0.5-0.4-0.4-1.1-0.6-0.4
Patch foraging total patch changes 18 sec0.50.71.6-0.10.4-1.31.31.0-0.80.9-0.9-0.9-0.7-0.6-0.6-1.2-1.0-0.4
Patch foraging total patch changes 24 sec0.30.52.30.5-0.5-1.51.50.7-0.20.3-0.30.40.50.70.7-0.70.40.4
Patch foraging total patch changes 6 sec1.01.62.7-0.70.8-0.70.51.3-1.41.5-1.5-1.4-1.3-1.4-1.4-1.6-1.4-1.4
Patch foraging time to switch 0 sec2.45.010.0-3.12.72.7-2.53.2-2.62.4-2.4-1.4-1.4-1.3-1.3-2.1-1.2-1.6
Patch foraging water rate 0 sec0.81.74.81.9-1.7-2.22.1-1.51.4-1.21.10.70.70.70.70.90.40.8
Patch foraging water rate 12 sec1.02.17.21.7-1.5-0.60.5-2.72.0-1.91.90.90.60.50.52.00.70.9
Patch foraging water rate 18 sec0.40.52.70.8-0.8-0.0-0.1-1.61.0-1.01.00.30.20.10.11.10.10.1
Patch foraging water rate 24 sec0.81.12.00.9-1.0-0.20.1-1.41.3-1.31.30.91.10.90.91.30.71.1
Patch foraging water rate 6 sec6.59.415.13.9-3.7-3.03.0-3.23.2-3.03.03.02.92.82.82.62.72.9
Seeking ratio, delayed vs. immediate footshock0.30.31.0-0.30.10.7-0.9-1.00.7-0.60.6-0.2-0.2-0.2-0.21.0-0.20.5
Distance traveled before self-admin1.31.76.01.5-1.4-0.70.5-2.51.8-1.71.70.70.80.60.61.90.60.6
Distance traveled after self-admin0.30.40.8-0.60.50.5-0.7-0.50.2-0.10.1-0.9-0.9-0.8-0.80.4-0.9-0.2
Extensor digitorum longus weight0.41.78.51.9-1.7-2.92.9-0.60.7-0.50.40.50.40.40.4-0.00.60.5
Bone: elastic displacement1.41.74.3-1.71.82.1-2.00.6-1.00.9-0.9-1.3-0.9-1.2-1.2-0.5-1.2-1.0
Bone: elastic work0.10.10.60.10.00.3-0.3-0.80.4-0.40.4-0.20.0-0.1-0.10.5-0.00.1
Bone: endosteal estimation3.16.99.32.7-3.1-1.71.6-2.52.8-2.72.72.82.72.82.82.42.92.8
Bone: endosteal perimeter1.73.54.51.9-2.1-1.11.0-1.82.0-2.02.02.02.02.02.01.82.02.1
Epididymis fat weight0.10.41.5-0.90.71.0-1.20.8-0.60.4-0.40.0-0.2-0.0-0.0-0.30.2-0.1
Delta time in closed arm before/after self-admin0.00.00.1-0.10.1-0.0-0.30.20.1-0.10.10.1-0.00.30.30.10.10.2
Delta time in open arm before/after self-admin0.70.71.81.2-1.1-0.50.7-1.30.8-0.80.80.70.90.60.60.70.50.1
Diff in mean of infusions in LGA sessions0.30.40.9-0.40.51.0-0.6-0.6-0.10.0-0.0-0.6-0.7-1.0-1.00.3-0.7-0.9
Delay discount exponential model param0.80.91.60.9-1.1-0.70.6-0.40.8-0.80.81.11.21.11.10.51.01.3
Extinction: sum of active levers before priming0.00.00.20.1-0.1-0.30.20.10.2-0.10.10.10.30.30.30.10.20.4
Active lever presses in extinction session 60.30.31.00.3-0.2-0.91.00.9-0.60.6-0.60.1-0.10.30.3-1.00.2-0.3
Bone: final force2.23.66.02.4-2.3-2.12.1-2.02.0-1.91.91.71.51.61.61.51.81.7
Bone: final moment2.94.77.42.7-2.6-2.32.2-2.32.3-2.22.22.01.81.91.91.82.02.0
Food consumed during 24 hour testing period0.60.83.3-0.20.21.8-1.8-1.30.7-0.90.90.50.30.20.21.40.2-0.1
Glucose2.13.34.9-2.12.22.2-2.10.9-1.51.4-1.4-1.8-2.1-2.0-2.0-0.9-1.8-2.1
Heart weight0.30.41.31.1-0.8-1.10.8-1.00.5-0.50.50.4-0.1-0.0-0.00.50.3-0.3
Delay discount hyperbolic model param0.91.01.90.9-1.2-0.70.6-0.40.8-0.80.81.21.41.31.30.61.11.4
Intermittent access intake day 1-15 change0.20.31.11.0-0.8-0.70.6-0.70.5-0.50.50.60.50.30.30.30.40.2
Intermittent access intake escalation0.30.61.71.3-1.1-0.90.8-0.90.6-0.60.60.80.80.50.50.40.60.3
Intermittent access intake escalation 20.10.10.40.4-0.2-0.20.2-0.60.3-0.20.2-0.0-0.2-0.2-0.20.3-0.2-0.3
Intermitt. access day 1 inactive lever presses0.10.41.21.0-1.1-0.20.3-0.90.4-0.50.50.81.00.50.50.40.4-0.5
Intermitt. access day 15 inactive lever presses0.81.73.11.7-1.8-1.11.4-1.31.1-1.11.11.41.61.31.30.81.20.8
Intermitt. access escalation Index0.60.91.3-0.81.10.4-0.30.8-1.01.0-1.0-1.0-1.0-1.1-1.1-0.9-1.0-1.2
Intermittent access day 1 total infusions0.20.40.90.9-0.9-0.70.8-0.50.4-0.30.30.60.60.60.60.10.50.3
Intermittent access day 15 total infusions0.10.20.70.8-0.7-0.30.2-0.60.0-0.10.10.40.40.10.1-0.00.1-0.5
Intermittent access terminal intake (last 3 days)0.10.20.70.8-0.8-0.30.2-0.70.2-0.30.30.50.40.30.30.20.2-0.2
Intermittent access total infusions0.50.61.71.2-1.3-0.80.8-1.00.5-0.50.50.80.90.70.70.30.60.2
Intermittent access day 1 locomotion0.40.50.90.6-0.70.30.1-1.00.6-0.70.70.90.80.80.80.70.70.2
Intermittent access day 15 total locomotion0.20.42.60.7-0.60.3-0.0-1.60.6-0.70.70.30.3-0.0-0.00.8-0.1-0.7
Intermittent access total locomotion1.31.53.41.5-1.5-0.30.8-1.91.2-1.31.31.41.31.11.11.31.10.5
Intermittent access standard deviation0.61.12.6-0.70.90.6-0.50.3-1.01.0-1.0-1.2-1.3-1.4-1.4-0.8-1.4-1.6
Left kidney weight4.521.042.96.5-6.2-6.36.0-4.74.3-4.03.93.93.63.53.53.13.63.2
Right kidney weight3.817.434.55.9-5.5-5.55.1-4.34.0-3.73.73.83.43.33.32.93.53.1
Cocaine induced anxiety0.71.01.50.7-0.80.2-0.2-1.11.1-1.21.21.11.11.11.11.21.11.1
Post-drug Anxiety0.70.81.60.4-0.70.2-0.4-0.40.7-0.80.81.21.31.21.20.71.21.1
Baseline Anxiety0.50.51.7-1.20.91.0-1.30.9-0.60.6-0.6-0.5-0.4-0.4-0.4-0.5-0.4-0.4
Tail length2.08.015.13.9-3.8-3.32.9-3.32.8-2.72.72.52.42.32.32.32.22.0
Length with tail2.39.816.54.0-4.1-3.22.9-3.23.1-3.03.03.22.92.92.92.62.92.6
Length without tail1.34.15.92.4-2.4-1.91.9-1.41.8-1.71.72.42.22.32.31.42.32.0
Times rat made contact with spout0.30.31.1-0.90.71.0-1.00.4-0.30.3-0.3-0.4-0.5-0.4-0.4-0.1-0.5-0.4
Lifetime Intake0.50.51.51.2-1.2-1.00.9-0.70.4-0.40.40.80.70.60.60.20.60.3
Liver weight, left2.03.312.12.8-2.4-3.53.5-1.41.2-1.01.01.11.10.90.90.41.00.8
Liver weight, right0.30.53.00.9-0.6-1.71.6-0.2-0.00.2-0.2-0.4-0.4-0.5-0.5-0.4-0.3-0.4
Locomotor activity0.50.72.20.3-0.0-1.41.50.7-0.60.8-0.8-0.7-0.9-0.8-0.8-1.1-0.6-0.5
Locomotor testing distance0.20.42.70.6-0.5-1.51.60.5-0.20.3-0.4-0.1-0.2-0.2-0.2-0.7-0.0-0.0
Locomotor testing rearing1.22.412.32.1-1.9-3.53.5-0.30.7-0.40.40.60.50.60.6-0.30.50.8
Locomotion in novel chamber1.01.24.3-1.81.72.1-1.90.9-0.80.7-0.7-0.8-0.7-0.6-0.6-0.3-0.6-0.1
Locomotion in novel chamber post-restriction0.61.02.6-1.41.41.2-1.61.1-0.80.7-0.7-1.0-1.1-0.8-0.8-0.4-0.7-0.1
Fecal boli incidents, locomotor time 10.10.10.30.3-0.2-0.10.1-0.60.4-0.40.40.20.00.20.20.4-0.10.0
Change in fecal boli incidents, locomotor task2.42.43.4-1.81.81.3-1.21.4-1.51.5-1.5-1.6-1.6-1.6-1.6-1.3-1.6-1.7
Time >=10cm from walls, locomotor time 10.20.20.4-0.60.50.5-0.60.6-0.60.5-0.5-0.3-0.4-0.4-0.4-0.5-0.1-0.5
Bouts of movement, locomotor time 10.30.41.50.10.10.8-0.8-1.20.7-0.70.7-0.1-0.1-0.1-0.11.1-0.2-0.1
Total resting periods, locomotor time 10.40.52.3-0.60.71.5-1.5-0.60.3-0.30.3-0.3-0.3-0.3-0.30.7-0.4-0.3
Rest time, locomotor task time 10.81.01.50.6-0.50.2-0.5-0.91.1-1.11.11.10.91.21.21.21.11.2
Distance moved, locomotor task time 10.60.91.4-0.60.5-0.50.30.9-1.11.1-1.1-1.2-1.1-1.2-1.2-1.2-1.0-1.0
Vertical activity count, locomotor time 11.02.44.7-1.11.20.1-0.30.8-1.41.5-1.5-2.1-2.0-2.2-2.2-1.4-1.9-1.8
Time >=10cm from walls, locomotor time 20.30.51.5-0.80.80.4-0.11.2-0.90.8-0.8-0.5-0.5-0.4-0.4-0.9-0.3-0.2
Bouts of movement, locomotor time 20.30.52.9-0.80.61.4-1.70.00.1-0.20.30.10.20.20.20.60.40.5
Total resting periods, locomotor time 20.30.63.4-0.80.61.5-1.8-0.10.3-0.40.40.30.30.40.40.80.60.7
Rest time, locomotor task time 20.30.42.1-0.50.30.8-1.4-0.40.5-0.50.50.10.20.20.20.80.20.7
Distance moved, locomotor task time 20.30.42.10.6-0.4-1.31.40.2-0.20.3-0.3-0.3-0.2-0.3-0.3-0.6-0.1-0.0
Vertical activity count, locomotor time 20.30.31.30.4-0.2-1.01.10.1-0.20.4-0.4-0.6-0.7-0.6-0.6-0.6-0.5-0.3
Light reinforcement 10.10.31.30.8-0.7-1.11.1-0.50.5-0.40.4-0.00.20.00.00.30.10.4
Light reinforcement 20.50.71.4-0.40.5-0.60.71.0-1.01.1-1.1-1.0-0.8-0.9-0.9-1.2-0.7-0.7
Bone: marrow area3.27.09.62.7-3.1-1.81.7-2.52.8-2.72.72.92.72.82.82.42.92.8
Bone: maximum diameter1.12.06.32.1-1.9-2.52.5-1.01.2-1.01.01.01.01.01.00.50.91.1
Bone: maximum force2.03.65.42.3-2.2-1.81.7-2.22.1-2.02.01.71.61.61.61.71.91.7
Bone: maximum moment2.64.56.52.5-2.5-2.01.9-2.42.4-2.22.21.91.81.81.82.02.12.0
Mean time between licks in bursts0.30.81.4-0.60.8-0.0-0.00.5-0.80.8-0.9-1.1-1.2-1.2-1.2-0.8-1.2-1.2
Mean num. licks in bursts0.30.52.9-1.00.51.6-1.70.10.1-0.20.20.1-0.00.00.00.50.10.0
Cd content in liver1.01.11.60.8-0.80.1-0.2-1.11.2-1.31.31.31.11.31.31.21.11.0
Co content in liver0.40.50.90.6-0.40.3-0.4-0.90.9-0.90.90.80.60.70.70.90.70.5
Cu content in liver2.02.43.81.9-2.0-1.71.7-1.01.3-1.31.21.71.71.81.80.91.51.3
Fe content in liver0.91.04.31.5-1.3-2.02.1-0.20.4-0.30.30.70.80.70.7-0.10.60.5
K content in liver0.50.52.31.0-0.9-1.41.5-0.10.3-0.20.20.40.60.60.6-0.20.10.4
Mg content in liver0.40.41.80.6-0.5-1.31.40.6-0.20.3-0.30.10.40.20.2-0.7-0.10.2
Mn content in liver0.10.10.40.2-0.2-0.50.60.4-0.30.4-0.4-0.10.1-0.0-0.0-0.5-0.2-0.1
Na content in liver0.70.71.6-0.60.5-0.30.41.3-1.01.1-1.1-0.8-0.6-0.6-0.6-1.2-1.0-0.6
Rb content in liver3.03.55.12.0-2.2-1.21.2-1.71.8-1.81.82.12.32.12.11.61.81.9
Se content in liver2.32.85.40.00.3-2.32.31.7-1.61.8-1.9-1.6-1.2-1.6-1.6-2.3-1.6-1.4
Sr content in liver6.15.37.5-2.42.61.4-1.41.8-2.22.2-2.2-2.7-2.7-2.7-2.7-1.9-2.6-2.4
Zn content in liver0.50.51.60.10.0-1.01.01.1-0.80.8-0.9-0.3-0.3-0.2-0.2-1.3-0.4-0.5
Bone: minimum diameter3.15.77.42.6-2.7-2.01.8-2.42.6-2.52.52.42.42.42.42.22.32.6
Time in familiar zone, hab. session 13.02.95.71.9-1.8-1.10.9-2.42.1-2.02.01.51.41.41.42.01.61.5
Time in novel zone, hab. session 11.31.33.8-0.91.0-0.00.21.9-1.51.5-1.5-0.9-0.8-0.8-0.8-1.7-0.9-0.8
Total zone transitions, hab. session 12.12.93.71.7-1.9-1.01.0-1.71.9-1.81.81.81.71.81.81.71.61.9
Total locomotion distance, hab. session 10.30.40.90.3-0.40.2-0.3-0.90.9-0.90.90.50.50.50.51.00.30.7
Locomotion velocity, hab. session 10.30.40.9-0.1-0.10.8-0.9-0.70.7-0.70.70.40.50.50.50.90.30.6
Time in familiar zone, hab. session 21.41.42.11.1-1.1-0.10.2-1.11.2-1.21.21.41.51.41.41.21.41.2
Time in novel zone, hab. session 20.60.61.1-0.70.7-0.1-0.01.1-0.91.0-1.0-0.8-0.9-0.8-0.8-1.0-0.8-0.7
Total zone transitions, hab. session 22.73.44.92.2-2.2-1.61.6-2.12.1-2.02.01.71.71.71.71.81.31.9
Total locomotion distance, hab. session 20.10.10.3-0.30.20.6-0.6-0.30.3-0.20.2-0.2-0.1-0.2-0.20.4-0.40.1
Locomotion velocity, hab. session 20.10.10.3-0.30.20.4-0.4-0.30.2-0.20.2-0.4-0.3-0.3-0.30.3-0.50.0
Novel to familiar place preference ratio0.10.10.60.4-0.2-0.70.7-0.30.1-0.00.0-0.3-0.3-0.3-0.3-0.0-0.20.0
Novelty place preference0.20.20.50.6-0.4-0.70.7-0.60.4-0.30.30.10.00.00.00.30.10.3
Time in novel zone, NPP test0.20.20.60.7-0.5-0.80.8-0.60.4-0.30.30.10.10.10.10.30.20.3
Total zone transitions, NPP test0.20.20.50.7-0.6-0.60.7-0.70.6-0.50.50.30.30.30.30.50.20.3
Total locomotion distance, NPP test0.00.10.20.10.1-0.20.2-0.10.00.0-0.0-0.4-0.3-0.3-0.3-0.1-0.5-0.2
Locomotion velocity, NPP test0.00.10.10.2-0.1-0.40.4-0.30.2-0.10.1-0.3-0.2-0.2-0.20.1-0.4-0.1
Intraocular pressure0.10.10.2-0.1-0.00.4-0.4-0.00.2-0.20.20.40.40.40.40.30.40.4
Delta distance traveled before/after self-admin2.02.12.9-1.71.61.0-1.01.5-1.51.5-1.5-1.6-1.7-1.5-1.5-1.3-1.6-1.2
Delta ambulatory time before/after self-admin1.72.13.1-1.61.61.0-1.21.2-1.41.4-1.4-1.6-1.8-1.5-1.5-1.2-1.6-1.5
Parametrial fat weight2.45.78.2-2.62.71.7-1.82.1-2.42.3-2.3-2.5-2.4-2.4-2.4-2.0-2.9-2.8
Pavlov. Cond. lever latency0.20.31.4-0.70.61.2-1.20.2-0.1-0.00.00.10.10.10.10.20.10.1
Pavlov. Cond. magazine entry latency0.81.01.8-0.40.6-0.80.81.2-1.01.1-1.1-1.1-1.1-1.0-1.0-1.3-1.0-0.8
Pavlov. Cond. change in total contacts0.10.10.2-0.30.3-0.0-0.10.3-0.30.4-0.4-0.4-0.5-0.5-0.5-0.3-0.5-0.5
Pavlov. Cond. index score0.40.51.50.20.0-1.21.20.6-0.50.7-0.7-0.7-0.7-0.7-0.7-0.9-0.7-0.6
Pavlov. Cond. latency score0.30.40.7-0.00.2-0.80.80.5-0.50.6-0.6-0.7-0.7-0.7-0.7-0.8-0.8-0.6
Pavlov. Cond. lever contacts0.20.21.10.6-0.5-1.01.0-0.10.00.0-0.0-0.0-0.0-0.0-0.0-0.2-0.0-0.0
Pavlov. Cond. magazine entry number0.30.41.1-0.00.01.0-1.1-0.70.5-0.60.60.50.50.50.50.90.50.2
Pavlov. Cond. intertrial magazine entries0.20.20.60.2-0.30.4-0.4-0.80.6-0.60.60.30.40.40.40.70.50.5
Pavlov. Cond. lever-magazine prob. diff.0.40.51.40.20.0-1.21.20.6-0.60.7-0.7-0.7-0.7-0.7-0.7-0.9-0.7-0.6
Pavlov. Cond. response bias0.40.53.10.6-0.5-1.71.70.6-0.30.4-0.4-0.2-0.2-0.2-0.2-0.8-0.2-0.0
Pavlov. Cond. lever latency0.60.81.60.7-0.70.2-0.1-0.60.7-0.80.81.31.31.21.20.81.10.7
Pavlov. Cond. magazine entry latency1.41.72.4-1.21.20.3-0.31.3-1.31.4-1.4-1.5-1.5-1.5-1.5-1.3-1.5-1.3
Pavlov. Cond. change in total contacts0.10.10.3-0.1-0.10.3-0.3-0.50.5-0.40.4-0.0-0.00.10.10.50.10.4
Pavlov. Cond. index score0.30.40.8-0.50.5-0.10.10.5-0.50.6-0.6-0.9-0.8-0.8-0.8-0.6-0.8-0.4
Pavlov. Cond. latency score0.81.11.9-1.01.00.3-0.30.9-1.01.0-1.0-1.4-1.3-1.3-1.3-0.9-1.3-1.0
Pavlov. Cond. lever contacts0.30.40.9-0.30.3-0.50.40.4-0.40.5-0.5-0.9-0.9-0.9-0.9-0.6-0.9-0.4
Pavlov. Cond. magazine entry number0.70.91.31.1-1.0-0.70.7-1.00.9-0.90.91.11.01.01.00.80.90.8
Pavlov. Cond. intertrial magazine entries3.75.66.92.4-2.4-1.21.2-2.42.5-2.52.52.62.62.62.62.32.52.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-0.50.5-0.20.20.5-0.50.6-0.6-0.9-0.9-0.8-0.8-0.7-0.8-0.5
Pavlov. Cond. response bias0.10.10.30.2-0.2-0.60.5-0.20.2-0.10.1-0.2-0.2-0.2-0.20.0-0.20.2
Time in closed arm before self-admin0.10.21.00.7-0.60.00.2-1.00.3-0.30.30.20.1-0.0-0.00.4-0.0-0.5
Time in closed arm after self-admin0.10.10.3-0.2-0.00.6-0.6-0.10.1-0.20.20.30.00.20.20.30.30.0
Time in open arm before self-admin0.50.51.7-1.11.10.2-0.41.3-0.70.7-0.7-0.8-0.7-0.5-0.5-0.7-0.50.1
Time in open arm after self-admin0.00.00.1-0.10.2-0.20.10.3-0.10.1-0.1-0.20.1-0.0-0.0-0.2-0.10.2
Bone: periosteal estimation2.55.47.52.6-2.7-2.12.0-2.12.4-2.32.32.32.32.32.32.02.42.5
Bone: periosteal perimeter2.64.56.62.2-2.4-1.81.7-1.72.2-2.12.12.22.22.32.31.72.32.6
Bone: post-yield work2.33.45.41.6-1.9-0.70.6-1.51.9-1.91.92.22.02.02.01.82.32.1
Progressive ratio test 1 active lever presses0.81.01.91.4-1.3-1.31.2-1.11.0-0.90.90.70.90.70.70.70.70.8
Progressive ratio test 1 breakpoint0.70.81.61.3-1.2-1.11.0-1.11.0-0.90.90.70.90.70.70.70.60.7
Progressive ratio test 1 inactive lever presses1.82.65.12.2-2.3-1.71.5-1.81.5-1.51.41.61.81.41.41.21.41.0
Progressive ratio test 2 active lever presses0.20.31.01.0-0.7-0.91.0-0.3-0.10.1-0.10.30.30.20.2-0.3-0.0-0.5
Progressive ratio test 2 breakpoint0.30.31.31.1-0.9-1.01.1-0.30.00.0-0.00.40.40.30.3-0.30.1-0.3
Progressive ratio test 2 inactive lever presses1.72.85.52.3-2.3-1.51.8-2.11.6-1.51.51.71.81.51.51.21.30.9
Incentive Sensitization - Responses0.30.41.31.1-0.9-0.71.0-0.60.2-0.20.20.70.60.50.50.00.3-0.3
Incentive Sensitization - Breakpoint0.20.30.91.0-0.7-0.71.0-0.3-0.0-0.00.00.50.50.30.3-0.20.1-0.5
Sum of active levers in priming session hrs 5-60.50.51.1-0.60.70.9-1.0-0.2-0.40.3-0.3-0.7-0.7-0.8-0.80.1-0.8-1.0
Progressive ratio0.00.00.2-0.00.10.1-0.1-0.40.2-0.20.2-0.1-0.1-0.1-0.10.1-0.10.0
Food seeking constrained by brief footshock0.81.04.7-0.00.30.6-0.6-2.21.1-1.01.0-0.9-0.9-0.9-0.91.6-0.9-0.1
Seeking ratio, punishment vs. effort0.30.41.70.5-0.40.1-0.1-1.30.9-0.90.90.30.20.20.21.20.20.4
Retroperitoneal fat weight4.418.724.4-4.84.92.8-2.84.8-4.84.7-4.7-4.3-4.3-4.2-4.2-4.3-4.1-4.4
Reaction time number correct0.30.62.50.4-0.3-1.61.50.4-0.20.4-0.4-0.7-0.6-0.6-0.6-0.8-0.7-0.3
Reaction time mean minus median0.10.20.8-0.50.20.9-0.80.2-0.1-0.00.00.30.20.40.40.20.3-0.0
Reaction time mean minus median AUC0.00.10.4-0.1-0.10.2-0.10.40.0-0.10.10.50.50.60.60.00.50.4
Reaction time num false alarms0.81.16.01.2-0.9-2.42.4-0.1-0.20.4-0.4-0.4-0.4-0.4-0.4-0.8-0.5-0.6
Reaction time num false alarms AUC0.61.04.60.8-0.6-2.12.10.1-0.40.6-0.6-0.7-0.6-0.7-0.7-1.0-0.8-0.8
Reaction time trials correct on left0.30.62.50.4-0.3-1.61.50.4-0.20.4-0.4-0.7-0.6-0.6-0.6-0.8-0.7-0.3
Reaction time trials on left0.30.62.50.4-0.3-1.61.50.4-0.30.4-0.4-0.7-0.6-0.6-0.6-0.8-0.7-0.3
Reaction time mean0.50.81.8-0.1-0.41.3-1.3-0.50.5-0.70.71.11.01.01.00.91.00.5
Reaction time mean AUC0.30.42.1-0.40.01.4-1.4-0.00.0-0.20.20.60.60.50.50.50.60.1
Median of all reaction times0.40.61.6-0.0-0.31.3-1.2-0.40.4-0.60.61.00.90.90.90.81.00.5
Reaction time omissions0.00.00.1-0.10.10.3-0.3-0.1-0.10.1-0.1-0.2-0.2-0.3-0.30.1-0.3-0.4
Reaction time false alarm rate0.10.20.60.3-0.2-0.80.7-0.1-0.30.3-0.3-0.4-0.3-0.4-0.4-0.4-0.4-0.7
Reaction time premature initiation rate0.60.83.9-1.21.11.9-2.00.1-0.40.2-0.2-0.4-0.7-0.6-0.60.3-0.5-0.6
Reaction time premature initiations0.40.71.4-1.11.01.1-1.20.5-0.60.6-0.5-0.8-1.0-0.9-0.9-0.3-0.9-0.8
Std. dev. reaction times0.20.31.3-0.2-0.11.1-1.1-0.30.2-0.40.40.70.60.60.60.60.50.1
Reaction time trials completed0.30.62.50.4-0.3-1.61.50.4-0.30.4-0.4-0.7-0.6-0.6-0.6-0.8-0.7-0.3
Reaction time trials AUC0.30.72.90.4-0.3-1.71.60.5-0.30.5-0.5-0.7-0.6-0.6-0.6-0.9-0.8-0.3
Run reversals in cocaine runway, females0.60.63.9-0.91.02.0-1.40.1-0.50.3-0.3-0.2-0.2-0.2-0.20.1-0.2-0.6
Run reversals in cocaine runway, males0.30.30.80.6-0.6-0.90.80.10.3-0.20.20.60.60.60.60.10.70.6
Latency to leave start box in cocaine runway0.10.10.40.30.10.6-0.2-0.60.3-0.30.30.20.10.10.10.50.0-0.5
Latency to leave start box in cocaine runway, F0.20.21.2-0.20.60.6-0.2-0.1-0.30.2-0.2-0.4-0.5-0.6-0.6-0.1-0.5-1.1
Latency to leave start box in cocaine runway, M1.41.31.81.2-1.1-0.50.6-1.11.1-1.11.11.31.31.31.31.01.21.1
Std. dev. time between licks in bursts0.20.31.50.8-0.5-1.21.2-0.50.2-0.10.1-0.3-0.1-0.1-0.1-0.0-0.3-0.0
Total sessions with >9 infusions1.72.13.81.9-1.9-1.81.7-1.21.3-1.21.21.41.41.41.40.91.31.3
Short access day 1 total inactive lever presses0.70.92.11.4-1.3-1.31.4-0.50.6-0.60.61.11.01.01.00.30.90.6
Short access day 10 total inactive lever presses0.10.10.8-0.10.10.9-0.3-0.50.2-0.30.30.30.30.20.20.60.1-0.2
Short access day 1 total infusions0.30.31.30.8-0.7-1.20.8-0.20.3-0.20.20.50.50.50.50.00.50.6
Short access day 10 total infusions0.30.42.50.8-0.8-1.61.00.1-0.10.3-0.3-0.00.1-0.0-0.0-0.6-0.1-0.1
Short access total infusions0.20.21.60.6-0.4-1.30.90.2-0.10.3-0.3-0.0-0.00.00.0-0.5-0.00.1
Short access day 1 locomotion1.11.33.01.5-1.5-1.61.7-0.50.7-0.60.61.21.21.31.30.31.10.9
Short access day 10 total locomotion0.50.83.10.6-0.80.60.0-1.81.1-1.11.20.80.80.60.61.40.60.4
Short access total locomotion0.40.51.50.8-0.9-0.50.6-1.20.8-0.80.80.40.50.40.40.80.30.3
One hour access (0.3 mA shock)1.61.93.81.6-1.8-0.20.3-2.01.3-1.41.41.71.61.31.31.31.40.5
Compulsive drug intake1.31.52.11.4-1.5-0.60.8-1.41.2-1.31.31.41.41.21.21.11.41.0
One hour access (shock baseline)0.10.10.40.4-0.4-0.30.2-0.0-0.30.2-0.20.30.10.10.1-0.4-0.1-0.6
Social response proportion0.30.30.91.0-0.7-0.60.6-0.60.4-0.40.40.70.40.40.40.30.6-0.1
Social responses2.53.35.52.3-2.2-1.71.7-1.71.7-1.71.72.01.91.81.81.41.81.5
Social time2.63.57.42.0-1.9-0.70.7-2.72.3-2.32.31.71.71.61.62.31.51.7
Soleus weight0.10.31.60.6-0.3-1.21.3-0.1-0.00.2-0.2-0.4-0.4-0.4-0.4-0.4-0.1-0.3
Bone: stiffness2.54.07.62.8-2.6-2.62.5-2.02.0-1.81.81.81.61.61.61.41.81.5
Tibialis anterior weight1.13.96.7-0.20.7-2.32.51.7-1.82.1-2.1-2.2-2.2-2.2-2.2-2.6-1.7-1.7
Time to tail flick, vehicle, before self-admin0.10.10.60.4-0.2-0.20.0-0.70.3-0.30.3-0.1-0.2-0.3-0.30.3-0.2-0.4
Time to tail flick, vehicle, after self-admin0.30.40.90.1-0.20.5-0.4-0.20.4-0.50.50.90.60.90.90.60.90.4
Time to tail flick, test, before self-admin0.30.30.9-0.20.20.6-0.5-0.90.6-0.60.6-0.3-0.3-0.4-0.41.0-0.3-0.0
Time to tail flick, test, after self-admin0.20.20.5-0.70.70.4-0.20.6-0.50.5-0.5-0.4-0.3-0.4-0.4-0.4-0.5-0.6
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.10.00.2-0.10.40.1-0.10.10.70.50.80.80.10.70.5
Delta time to tail flick, test, before/after SA0.10.10.5-0.0-0.1-0.20.20.7-0.50.4-0.40.20.40.30.3-0.60.1-0.2
Tibia length3.610.016.34.0-4.0-3.73.5-3.13.2-2.92.92.93.02.92.92.42.63.0
Ambulatory time before self-admin1.32.04.41.5-1.6-0.80.7-2.11.8-1.71.71.01.11.01.01.91.01.2
Ambulatory time after self-admin0.20.31.1-0.10.10.4-0.6-1.10.6-0.50.5-0.5-0.6-0.4-0.40.8-0.5-0.1
Bone: tissue strength0.30.30.6-0.10.30.3-0.4-0.70.2-0.20.2-0.6-0.7-0.8-0.80.4-0.7-0.7
Total heroin consumption0.10.10.2-0.10.2-0.00.20.1-0.20.3-0.3-0.4-0.3-0.3-0.3-0.2-0.5-0.4
Bone: trabecular number0.00.10.3-0.2-0.0-0.30.20.50.00.0-0.00.00.00.10.1-0.20.20.5
Bone: trabecular spacing0.00.00.00.00.10.00.0-0.2-0.00.0-0.0-0.1-0.1-0.1-0.10.0-0.1-0.1
Bone: trabecular thickness0.10.10.90.4-0.3-0.90.80.3-0.00.1-0.10.10.10.20.2-0.30.20.1
Bone: trabecular tissue density1.01.52.4-1.11.30.6-0.51.4-1.61.5-1.5-1.1-1.2-1.2-1.2-1.4-1.1-1.5
Water consumed over 24 hours0.50.71.90.6-0.60.4-0.4-1.41.1-1.21.20.70.50.50.51.30.70.7
Number of responses in last shaping day0.20.21.10.7-0.5-1.00.90.4-0.30.3-0.30.30.20.30.3-0.50.2-0.0