Hub : Genes

Ythdf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	XM_063282042.1	0.05	0.04	1.3e-03	0.01	0.01	0.01	0.01	2.7e-02	1.8e-02	2.2e-02	4.0e-02
2	Adipose	alternative polyA	XM_006232168.3	0.06	0.05	5.0e-04	0.01	0.01	0.01	0.01	2.0e-02	2.6e-02	1.9e-02	3.8e-02
3	Adipose	alternative polyA	XM_063282040.1	0.06	0.05	2.9e-04	0.01	0.01	0.01	0.01	1.1e-02	8.7e-03	6.9e-03	1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.4	0.7	1.1	1.1	0.7	-0.7
Area under the delay curve	0.4	0.6	1.2	-1.1	-0.6	0.5
BMI with tail	2.8	9.7	11.5	-3.4	-3.0	2.9
BMI without tail	1.2	6.4	8.2	-2.9	-2.4	2.3
Body weight	2.2	9.5	12.9	-3.6	-2.9	2.7
Weight adjusted by age	0.3	0.8	1.1	-1.0	-0.9	0.8
Bone surface	0.1	0.3	0.4	-0.4	-0.6	0.6
Bone volume	0.0	0.0	0.0	0.0	-0.2	0.2
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.3	0.0	-0.0
Number of licking bursts	0.7	2.1	3.5	-1.9	-1.2	1.1
Context. condit. distance diff. score	0.1	0.1	0.3	-0.5	0.0	-0.0
Locomotion velocity, session 1	0.4	0.5	0.5	-0.7	-0.7	0.7
Locomotion distance, session 1	0.3	0.3	0.4	-0.6	-0.5	0.6
Locomotion velocity, session 2	3.0	3.6	4.7	-2.2	-1.7	1.7
Locomotion distance, session 2	0.4	0.5	0.5	-0.7	-0.7	0.7
Locomotion velocity, session 3	0.9	1.0	1.9	-1.4	-0.8	0.7
Locomotion distance, session 3	0.8	0.9	1.5	-1.2	-0.8	0.7
Stereotopy head waving bouts, day 3	0.3	0.4	0.8	0.9	0.5	-0.4
Stereotopy head waving duration, day 3	0.3	0.4	0.8	0.9	0.4	-0.3
Locomotion velocity, session 7	1.8	1.9	2.9	1.7	1.2	-1.2
Locomotion distance, session 7	1.2	1.5	2.4	1.5	1.1	-1.0
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	-0.8	-0.1	0.0
Stereotopy head waving duration, day 7	0.1	0.1	0.4	-0.6	-0.1	0.1
Locomotion velocity, session 8	0.6	0.7	1.4	-1.2	-0.6	0.5
Locomotion distance, session 8	0.7	1.1	2.0	-1.4	-0.8	0.7
Degree of sensitization distance	2.4	2.6	5.0	2.2	1.3	-1.2
Degree of sensitization stereotypy	0.9	1.0	2.5	-1.6	-0.6	0.5
Conditioned locomotion	2.1	2.5	2.7	1.7	1.5	-1.5
Cocaine response after cond. corrected	0.1	0.1	0.1	0.2	-0.3	0.4
Cocaine response after cond. not corrected	0.1	0.1	0.1	0.3	-0.3	0.3
Cocaine response before conditioning	0.1	0.1	0.2	0.5	0.3	-0.3
Saline control response	0.3	0.5	0.7	-0.9	-0.6	0.6
Bone: connectivity density	0.4	0.7	1.5	1.2	0.6	-0.5
Bone: cortical apparent density	0.4	0.6	0.7	-0.9	-0.7	0.7
Bone: cortical area	0.1	0.1	0.2	-0.5	0.1	-0.2
Bone: cortical porosity	0.3	0.3	0.6	0.8	0.4	-0.4
Bone: cortical porosity	0.2	0.2	0.4	0.6	0.4	-0.4
Bone: cortical thickness	0.7	1.2	1.7	0.7	1.2	-1.3
Bone: cortical thickness	1.3	1.6	1.9	-1.4	-1.3	1.2
Bone: cortical tissue density	0.4	0.7	0.9	-0.9	-0.8	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.0	0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	-0.0	0.0
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	0.1	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	-0.3	0.3
Incentive salience index mean	0.0	0.1	0.1	-0.3	0.2	-0.2
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.8	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	-0.8	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.4	0.7	1.0	-1.0	-0.8	0.7
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	-0.3	0.3
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.1	-0.1
Condit. Reinf. lever presses	0.6	0.8	0.8	0.9	0.9	-0.9
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.3	-0.2	0.2
Conditioned reinforcement - actives	0.0	0.0	0.0	0.1	0.1	-0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.2	-0.2	0.2
Conditioned locomotion	0.4	0.6	0.7	-0.8	-0.7	0.7
Patch foraging indifference point 0 sec	0.1	0.4	0.7	-0.1	0.8	-0.8
Patch foraging indifference point AUC	0.2	0.5	1.4	1.2	0.3	-0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.4	0.2	-0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	0.1	0.3	-0.4
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.8	-0.3	0.2
Delay disc. indifference point, 24s delay	0.2	0.4	0.5	0.7	0.6	-0.5
Delay disc. indifference point, 4s delay	1.7	1.8	2.9	-1.7	-1.1	1.1
Delay disc. indifference point, 8s delay	0.4	0.6	1.0	-1.0	-0.7	0.6
Indifference point function ln k	0.8	2.4	3.4	-1.8	-1.4	1.3
Indifference point function log k	0.8	2.4	3.4	-1.8	-1.4	1.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.2	-0.4	0.4	-0.5
Patch foraging total patch changes 12 sec	0.2	0.3	0.3	0.6	0.5	-0.5
Patch foraging total patch changes 18 sec	0.2	0.4	0.6	0.8	0.6	-0.5
Patch foraging total patch changes 24 sec	0.2	0.6	0.7	0.8	0.8	-0.7
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.1	0.1	-0.1
Patch foraging time to switch 0 sec	0.2	0.6	1.0	-1.0	-0.6	0.6
Patch foraging water rate 0 sec	0.1	0.2	0.3	0.6	0.4	-0.4
Patch foraging water rate 12 sec	0.2	0.6	1.6	1.3	0.4	-0.3
Patch foraging water rate 18 sec	0.2	0.5	1.1	1.1	0.4	-0.4
Patch foraging water rate 24 sec	0.1	0.2	0.2	0.3	-0.4	0.5
Patch foraging water rate 6 sec	0.1	0.1	0.1	0.3	-0.2	0.3
Seeking ratio, delayed vs. immediate footshock	1.1	1.6	2.4	1.6	1.1	-1.0
Distance traveled before self-admin	1.6	3.5	5.6	-2.4	-1.6	1.5
Distance traveled after self-admin	2.6	4.5	7.3	-2.7	-1.8	1.7
Extensor digitorum longus weight	5.9	23.6	28.1	-5.3	-4.7	4.5
Bone: elastic displacement	1.5	1.9	3.0	1.7	1.2	-1.1
Bone: elastic work	0.6	0.8	0.9	1.0	0.8	-0.8
Bone: endosteal estimation	2.0	5.0	5.7	-2.4	-2.2	2.2
Bone: endosteal perimeter	0.6	1.5	2.7	-1.6	-1.0	0.9
Epididymis fat weight	1.7	8.4	10.7	-3.3	-2.7	2.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.5	0.4	-0.4
Delta time in open arm before/after self-admin	0.8	1.0	1.0	-1.0	-1.0	1.0
Diff in mean of infusions in LGA sessions	0.8	1.4	1.4	1.2	1.2	-1.2
Delay discount exponential model param	0.4	0.6	1.1	1.1	0.6	-0.5
Extinction: sum of active levers before priming	0.8	1.2	1.4	-1.2	-1.0	1.0
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.6	-0.4	0.3
Bone: final force	1.5	2.4	3.4	-1.9	-1.4	1.4
Bone: final moment	1.1	1.8	2.7	-1.6	-1.2	1.2
Food consumed during 24 hour testing period	1.6	3.2	5.2	-2.3	-1.6	1.4
Glucose	0.1	0.2	0.4	-0.7	-0.4	0.3
Heart weight	0.9	1.4	1.7	-1.3	-1.1	1.1
Delay discount hyperbolic model param	0.6	0.7	1.4	1.2	0.7	-0.6
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.2	-0.2	0.2
Intermittent access intake escalation	0.0	0.0	0.0	-0.2	-0.2	0.2
Intermittent access intake escalation 2	0.0	0.0	0.0	0.2	0.0	-0.0
Intermitt. access day 1 inactive lever presses	0.1	0.7	0.9	-1.0	-0.8	0.8
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.0	-0.0	-0.1	0.1
Intermitt. access escalation Index	0.0	0.1	0.2	0.4	0.4	-0.3
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.2	0.1	-0.1
Intermittent access day 15 total infusions	0.2	0.5	0.8	0.9	0.6	-0.6
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.4	0.2	-0.2
Intermittent access total infusions	0.2	0.3	0.4	0.6	0.4	-0.4
Intermittent access day 1 locomotion	0.4	0.7	0.8	-0.9	-0.8	0.8
Intermittent access day 15 total locomotion	0.0	0.2	0.2	-0.4	-0.4	0.4
Intermittent access total locomotion	0.4	0.4	0.4	-0.7	-0.7	0.7
Intermittent access standard deviation	0.0	0.0	0.0	-0.1	-0.2	0.2
Left kidney weight	0.5	4.2	5.0	-2.2	-2.0	1.9
Right kidney weight	0.5	3.2	5.3	-2.3	-1.5	1.4
Cocaine induced anxiety	0.1	0.3	0.3	0.6	0.5	-0.5
Post-drug Anxiety	0.4	0.4	0.4	0.7	0.6	-0.6
Baseline Anxiety	0.0	0.1	0.1	-0.3	-0.2	0.2
Tail length	0.0	0.1	0.4	-0.6	-0.0	-0.0
Length with tail	0.5	2.2	3.8	-2.0	-1.2	1.1
Length without tail	0.8	4.0	5.2	-2.3	-1.9	1.8
Times rat made contact with spout	2.1	2.4	4.5	-2.1	-1.2	1.1
Lifetime Intake	0.1	0.2	0.2	0.5	0.4	-0.4
Liver weight, left	0.7	1.3	2.1	-1.5	-0.9	0.9
Liver weight, right	5.3	9.3	10.4	-3.2	-3.0	2.9
Locomotor activity	1.9	3.0	3.6	-1.9	-1.7	1.6
Locomotor testing distance	1.3	3.1	3.7	-1.9	-1.7	1.6
Locomotor testing rearing	0.0	0.0	0.1	0.2	0.0	-0.0
Locomotion in novel chamber	0.0	0.0	0.1	-0.0	0.3	-0.3
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	0.4	0.3	-0.3
Fecal boli incidents, locomotor time 1	0.6	1.6	1.8	-1.1	-1.3	1.3
Change in fecal boli incidents, locomotor task	0.7	0.8	0.8	0.8	0.9	-0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.0	-0.2	0.2
Bouts of movement, locomotor time 1	0.1	0.2	0.2	-0.2	-0.4	0.4
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.2	-0.5	0.6
Rest time, locomotor task time 1	1.5	2.4	3.3	-0.7	-1.8	1.8
Distance moved, locomotor task time 1	0.5	1.4	2.2	0.2	1.4	-1.5
Vertical activity count, locomotor time 1	0.4	2.8	4.3	0.4	2.0	-2.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	0.1	-0.1
Bouts of movement, locomotor time 2	0.7	2.4	3.2	0.9	1.7	-1.8
Total resting periods, locomotor time 2	0.4	1.4	2.0	0.6	1.4	-1.4
Rest time, locomotor task time 2	0.5	0.8	1.1	-0.5	-1.0	1.0
Distance moved, locomotor task time 2	0.8	1.1	1.3	0.7	1.2	-1.1
Vertical activity count, locomotor time 2	0.0	0.1	0.2	0.0	0.4	-0.4
Light reinforcement 1	0.5	2.0	3.0	-1.7	-1.3	1.2
Light reinforcement 2	0.5	1.1	2.8	-1.7	-0.6	0.5
Bone: marrow area	2.2	5.3	5.9	-2.4	-2.2	2.2
Bone: maximum diameter	0.5	0.9	1.9	-1.4	-0.7	0.6
Bone: maximum force	1.4	2.9	3.6	-1.9	-1.6	1.5
Bone: maximum moment	1.2	2.2	2.8	-1.7	-1.4	1.4
Mean time between licks in bursts	0.2	1.0	1.4	-0.2	-1.2	1.2
Mean num. licks in bursts	0.3	0.7	0.8	0.9	0.8	-0.8
Cd content in liver	2.0	2.2	2.5	-1.3	-1.6	1.6
Co content in liver	1.1	1.3	1.4	-1.0	-1.2	1.2
Cu content in liver	0.1	0.2	0.4	0.6	0.2	-0.2
Fe content in liver	1.4	1.7	2.5	0.5	1.5	-1.6
K content in liver	0.9	0.9	1.0	0.9	1.0	-1.0
Mg content in liver	0.2	0.2	0.6	0.8	0.3	-0.3
Mn content in liver	0.2	0.2	0.3	-0.5	-0.4	0.4
Na content in liver	0.1	0.1	0.2	-0.2	0.4	-0.4
Rb content in liver	1.5	1.8	2.1	1.5	1.3	-1.3
Se content in liver	0.2	0.2	0.3	-0.1	0.5	-0.6
Sr content in liver	0.2	0.2	0.2	0.5	-0.3	0.4
Zn content in liver	0.0	0.1	0.1	0.2	-0.2	0.3
Bone: minimum diameter	0.1	0.1	0.3	-0.5	-0.3	0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.5	0.4	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.4	0.4
Total zone transitions, hab. session 1	0.4	0.5	0.7	-0.8	-0.7	0.7
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.5	-0.2	0.2
Locomotion velocity, hab. session 1	0.3	0.4	0.6	-0.8	-0.5	0.5
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.4	-0.2	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.5	0.4	-0.4
Total zone transitions, hab. session 2	0.5	0.7	1.1	-1.0	-0.7	0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.5	-0.2	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.6	-0.2	0.2
Novel to familiar place preference ratio	2.2	2.9	3.0	1.7	1.7	-1.7
Novelty place preference	1.6	2.1	2.2	1.4	1.5	-1.5
Time in novel zone, NPP test	2.0	2.4	2.6	1.5	1.6	-1.6
Total zone transitions, NPP test	0.2	0.3	0.7	-0.8	-0.3	0.3
Total locomotion distance, NPP test	0.1	0.2	0.4	-0.6	-0.3	0.3
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.5	-0.2	0.2
Intraocular pressure	3.1	5.1	6.6	-2.6	-2.1	2.1
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3
Delta ambulatory time before/after self-admin	0.3	0.5	0.7	0.9	0.7	-0.6
Parametrial fat weight	1.1	2.6	4.0	-2.0	-1.4	1.3
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	-0.1	0.1
Pavlov. Cond. magazine entry latency	1.0	1.3	1.3	-1.1	-1.1	1.1
Pavlov. Cond. change in total contacts	0.8	0.9	1.4	-1.2	-0.8	0.8
Pavlov. Cond. index score	1.1	1.5	2.0	-1.4	-1.1	1.1
Pavlov. Cond. latency score	0.6	0.8	1.3	-1.1	-0.8	0.7
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.7	-0.4	0.4
Pavlov. Cond. magazine entry number	2.0	2.5	2.8	1.7	1.5	-1.5
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.2	1.1	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	2.2	-1.5	-1.1	1.1
Pavlov. Cond. response bias	1.5	1.9	2.4	-1.6	-1.3	1.3
Pavlov. Cond. lever latency	1.5	2.1	2.2	-1.4	-1.5	1.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	-0.3	-0.7	0.7
Pavlov. Cond. change in total contacts	0.3	0.7	0.8	0.7	0.9	-0.9
Pavlov. Cond. index score	0.1	0.1	0.1	0.4	0.3	-0.3
Pavlov. Cond. latency score	0.0	0.1	0.1	0.3	0.2	-0.2
Pavlov. Cond. lever contacts	1.6	2.3	2.5	1.4	1.6	-1.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.1	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.2	0.1	-0.2
Pavlov. Cond. response bias	0.6	0.9	0.9	0.9	0.9	-0.9
Time in closed arm before self-admin	0.4	0.7	0.8	0.9	0.8	-0.7
Time in closed arm after self-admin	0.6	0.7	0.8	0.9	0.8	-0.8
Time in open arm before self-admin	0.0	0.0	0.1	0.1	0.2	-0.3
Time in open arm after self-admin	3.5	3.9	4.7	-2.2	-1.9	1.8
Bone: periosteal estimation	1.0	2.4	3.4	-1.9	-1.4	1.3
Bone: periosteal perimeter	0.2	0.5	1.3	-1.1	-0.4	0.3
Bone: post-yield work	2.2	3.9	4.3	-1.8	-2.0	2.1
Progressive ratio test 1 active lever presses	0.2	0.4	0.5	-0.7	-0.6	0.6
Progressive ratio test 1 breakpoint	0.3	0.4	0.5	-0.7	-0.6	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.2	0.5	0.3	-0.3
Progressive ratio test 2 active lever presses	0.0	0.1	0.1	0.3	0.2	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	0.3	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	-0.3	-0.3	0.3
Incentive Sensitization - Responses	0.2	0.5	0.6	0.8	0.6	-0.6
Incentive Sensitization - Breakpoint	0.2	0.4	0.6	0.7	0.6	-0.6
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.4	-1.2	-1.0	1.0
Progressive ratio	0.1	0.2	0.5	0.7	0.4	-0.3
Food seeking constrained by brief footshock	0.2	0.3	0.8	0.9	-0.1	0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	-0.2	-0.5	0.5
Retroperitoneal fat weight	1.1	5.1	5.1	-2.3	-2.3	2.2
Reaction time number correct	0.2	0.9	1.3	1.1	0.8	-0.8
Reaction time mean minus median	1.3	8.6	9.4	-2.6	-3.1	3.1
Reaction time mean minus median AUC	1.4	9.3	10.5	-2.6	-3.2	3.2
Reaction time num false alarms	0.5	0.8	0.8	0.8	0.9	-0.9
Reaction time num false alarms AUC	0.2	0.4	0.4	0.6	0.6	-0.6
Reaction time trials correct on left	0.2	0.9	1.3	1.1	0.8	-0.8
Reaction time trials on left	0.2	0.7	1.2	1.1	0.7	-0.7
Reaction time mean	2.6	5.7	6.5	-2.0	-2.5	2.5
Reaction time mean AUC	2.4	5.7	6.7	-2.0	-2.6	2.6
Median of all reaction times	2.0	3.2	3.8	-1.4	-1.9	2.0
Reaction time omissions	2.4	4.0	4.2	-1.9	-2.1	2.0
Reaction time false alarm rate	0.0	0.1	0.1	-0.0	0.3	-0.3
Reaction time premature initiation rate	0.0	0.0	0.1	0.3	0.1	-0.0
Reaction time premature initiations	0.0	0.1	0.2	0.5	0.1	-0.1
Std. dev. reaction times	2.3	7.6	8.2	-2.5	-2.9	2.9
Reaction time trials completed	0.2	0.7	1.2	1.1	0.7	-0.7
Reaction time trials AUC	0.2	0.7	1.0	1.0	0.7	-0.7
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.6	-0.3	0.3
Run reversals in cocaine runway, males	0.4	0.4	0.5	0.3	0.7	-0.7
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	0.0	-0.0
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.1	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.3	0.1	-0.1
Std. dev. time between licks in bursts	0.0	0.1	0.2	0.5	0.0	-0.0
Total sessions with >9 infusions	0.2	0.2	0.4	-0.6	-0.4	0.4
Short access day 1 total inactive lever presses	0.1	0.2	0.4	-0.6	-0.3	0.3
Short access day 10 total inactive lever presses	0.2	1.5	2.0	1.4	1.1	-1.1
Short access day 1 total infusions	0.5	1.0	1.7	-1.3	-0.8	0.8
Short access day 10 total infusions	0.3	0.4	0.5	0.6	0.7	-0.7
Short access total infusions	0.0	0.0	0.0	-0.0	0.2	-0.2
Short access day 1 locomotion	0.6	1.0	1.6	-1.3	-0.8	0.8
Short access day 10 total locomotion	0.1	0.4	0.6	-0.8	-0.6	0.6
Short access total locomotion	1.0	1.5	2.1	-1.5	-1.1	1.0
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	0.2	-0.2
Compulsive drug intake	0.0	0.1	0.1	0.1	0.3	-0.3
One hour access (shock baseline)	0.3	0.8	1.3	1.1	0.8	-0.7
Social response proportion	0.6	0.8	0.8	-0.9	-0.9	0.9
Social responses	1.1	1.4	1.6	-1.2	-1.2	1.1
Social time	0.1	0.1	0.3	0.5	-0.2	0.2
Soleus weight	0.3	0.8	1.7	-1.3	-0.7	0.6
Bone: stiffness	1.7	3.1	4.2	-2.0	-1.6	1.6
Tibialis anterior weight	5.5	18.8	24.0	-4.9	-4.1	3.9
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.0	0.4	-0.4
Time to tail flick, vehicle, after self-admin	1.4	2.8	3.4	1.8	1.6	-1.6
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	-0.2	0.2
Time to tail flick, test, after self-admin	4.6	4.9	5.9	2.4	2.1	-2.1
Delta time to tail flick, vehicle, before/after SA	3.0	3.3	4.5	2.1	1.6	-1.6
Delta time to tail flick, test, before/after SA	0.9	1.1	1.5	1.2	1.0	-0.9
Tibia length	0.1	0.2	0.3	-0.6	-0.4	0.4
Ambulatory time before self-admin	1.6	4.8	7.4	-2.7	-1.9	1.8
Ambulatory time after self-admin	0.9	1.4	2.5	-1.6	-1.0	0.9
Bone: tissue strength	0.1	0.1	0.1	0.3	0.4	-0.4
Total heroin consumption	0.0	0.0	0.0	0.1	0.1	-0.1
Bone: trabecular number	0.4	0.7	1.0	1.0	0.8	-0.8
Bone: trabecular spacing	0.0	0.0	0.0	0.1	0.1	-0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.4	0.2	-0.2
Bone: trabecular tissue density	0.5	0.8	2.2	-1.5	-0.4	0.3
Water consumed over 24 hours	0.3	0.5	1.0	-1.0	-0.5	0.5
Number of responses in last shaping day	1.2	1.5	1.9	-1.4	-1.2	1.1