Hub : Genes

Yipf4l1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Yipf4l1	0.1	0.1	2.0e-03	0.04	0.04	0.05	0.04	4.9e-04	3.2e-04	5.7e-05	2.9e-04
2	Liver	gene expression	Yipf4l1	0.28	0.13	1.3e-10	0.08	0.08	0.09	0.07	3.9e-09	6.8e-09	9.4e-10	1.0e-08
3	Adipose	gene expression	Yipf4l1	0.23	0.13	1.9e-12	0.1	0.1	0.1	0.1	2.1e-11	2.0e-11	9.5e-11	2.8e-11
4	Brain	gene expression	Yipf4l1	0.1	0.08	4.3e-06	0.06	0.05	0.07	0.05	4.4e-06	7.9e-06	6.4e-07	1.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.1	3.8	4.8	-2.2	-2.0	2.0	-1.5
Area under the delay curve	0.0	0.0	0.0	0.2	0.1	0.2	-0.0
BMI with tail	1.5	5.4	10.9	3.3	1.8	-2.1	1.8
BMI without tail	1.0	5.5	9.6	3.1	2.2	-2.3	1.6
Body weight	1.2	5.3	9.2	3.0	1.5	-2.4	2.1
Weight adjusted by age	0.1	0.2	0.5	0.6	-0.0	0.1	-0.7
Bone surface	0.4	0.7	1.4	-1.2	-0.9	0.8	-0.3
Bone volume	1.1	2.2	2.9	-1.7	-1.7	1.5	-0.9
Breakpoint value in progressive ratio session	0.5	0.8	1.3	-1.1	-0.7	0.7	-1.0
Number of licking bursts	0.5	1.4	2.5	1.6	0.7	-1.0	1.3
Context. condit. distance diff. score	0.2	0.2	0.5	-0.3	-0.2	0.5	-0.7
Locomotion velocity, session 1	0.4	0.5	1.1	0.2	0.4	-0.8	1.1
Locomotion distance, session 1	0.6	0.8	2.3	-0.7	-1.5	0.7	-0.1
Locomotion velocity, session 2	0.2	0.3	0.7	0.9	-0.2	0.0	0.6
Locomotion distance, session 2	0.2	0.3	0.9	0.5	-0.9	-0.1	0.3
Locomotion velocity, session 3	0.1	0.1	0.1	0.2	0.2	0.1	0.4
Locomotion distance, session 3	0.1	0.1	0.2	0.1	0.2	-0.3	0.5
Stereotopy head waving bouts, day 3	1.9	2.3	4.4	-2.1	-1.0	1.3	-1.5
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.9	-0.0	0.6	-0.5
Locomotion velocity, session 7	0.1	0.1	0.3	0.3	-0.2	0.1	0.6
Locomotion distance, session 7	1.0	1.2	2.3	1.5	1.1	-0.9	0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.1	0.4	-0.1	0.2
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.5	-0.2	0.6	-0.3
Locomotion velocity, session 8	0.7	0.8	1.5	-1.2	-1.0	0.7	-0.6
Locomotion distance, session 8	0.2	0.2	0.4	-0.2	-0.5	0.5	-0.6
Degree of sensitization distance	0.8	0.9	2.1	1.5	1.0	-0.7	0.3
Degree of sensitization stereotypy	0.5	0.6	1.3	1.1	0.8	-0.5	0.5
Conditioned locomotion	1.9	2.2	3.7	-0.7	-1.1	1.9	-1.8
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.2	-0.3	0.4	-0.2
Cocaine response after cond. not corrected	0.4	0.6	0.7	-0.8	-0.8	0.8	-0.6
Cocaine response before conditioning	2.1	2.5	2.8	-1.7	-1.5	1.5	-1.7
Saline control response	1.1	1.5	2.1	-1.4	-1.0	1.2	-1.2
Bone: connectivity density	1.3	2.1	2.3	-1.5	-1.2	1.5	-1.5
Bone: cortical apparent density	0.2	0.2	0.8	-0.9	0.1	-0.0	-0.5
Bone: cortical area	0.1	0.2	0.8	0.1	-0.2	-0.1	0.9
Bone: cortical porosity	3.4	3.7	4.6	-2.0	-2.2	2.1	-1.3
Bone: cortical porosity	3.1	3.5	4.9	-1.9	-2.2	2.0	-1.1
Bone: cortical thickness	0.4	0.6	1.5	0.4	0.5	-0.7	1.2
Bone: cortical thickness	0.6	0.7	1.3	-1.0	-1.1	0.6	0.0
Bone: cortical tissue density	0.1	0.2	0.7	-0.9	0.0	-0.1	-0.4
Condit. Reinf. active minus inactive responses	1.6	1.8	2.4	1.3	1.0	-1.5	1.5
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.0	0.4	1.4	-1.6	1.7
Condit. Reinf. active responses	0.1	0.1	0.3	0.5	-0.2	-0.3	0.4
Condit. Reinf. inactive responses	1.3	1.7	3.0	-0.4	-1.7	1.3	-1.4
Incentive salience index mean	0.2	0.3	0.7	0.5	-0.3	-0.3	0.8
Condit. Reinf. lever presses	1.0	1.6	3.5	-0.6	-1.9	1.5	-0.5
Condit. Reinf. active minus inactive responses	0.7	1.1	1.2	-1.1	-1.0	1.1	-1.1
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.8	-0.4	-0.8	0.9	-0.6
Condit. Reinf. active responses	0.6	0.8	1.3	-0.7	-0.9	0.8	-1.1
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.1	-0.7	0.4	-0.5
Condit. Reinf. lever presses	0.7	1.0	1.4	-1.2	-1.1	1.0	-0.7
Condit. Reinf. lever reinforcers received	0.6	0.9	1.1	-0.8	-1.0	0.9	-1.0
Conditioned reinforcement - actives	1.2	4.8	9.1	-3.0	-2.2	2.0	-1.2
Conditioned reinforcement - inactives	1.9	5.2	8.6	-2.9	-2.2	2.4	-1.3
Conditioned locomotion	2.9	4.3	9.8	-3.1	-2.1	1.5	-0.9
Patch foraging indifference point 0 sec	0.3	0.9	1.6	0.7	0.7	-1.1	1.3
Patch foraging indifference point AUC	0.0	0.1	0.2	0.3	0.4	0.1	0.5
Delay disc. indifference point, 0s delay	1.2	1.3	2.2	0.9	1.5	-0.9	1.2
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1
Delay disc. indifference point, 2s delay	0.1	0.2	0.2	-0.4	0.5	-0.3	0.4
Delay disc. indifference point, 24s delay	2.0	3.2	4.8	-1.9	-2.2	1.8	-1.1
Delay disc. indifference point, 4s delay	0.2	0.3	0.5	0.7	0.7	-0.3	-0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.2	0.1	0.3	0.1
Indifference point function ln k	0.6	1.8	2.1	-1.4	-1.2	1.5	-1.3
Indifference point function log k	0.6	1.8	2.1	-1.4	-1.2	1.5	-1.3
Patch foraging total patch changes 0 sec	0.3	0.9	1.5	0.8	0.6	-1.0	1.2
Patch foraging total patch changes 12 sec	1.1	1.5	3.1	1.8	1.0	-0.9	1.0
Patch foraging total patch changes 18 sec	0.3	0.8	1.3	0.7	0.8	-1.2	0.8
Patch foraging total patch changes 24 sec	0.6	2.1	3.1	1.8	1.1	-1.2	1.6
Patch foraging total patch changes 6 sec	1.9	3.2	4.6	1.8	1.6	-1.6	2.1
Patch foraging time to switch 0 sec	0.2	0.6	1.4	0.5	1.2	-0.8	0.0
Patch foraging water rate 0 sec	0.5	1.9	3.0	-1.6	-1.7	1.2	-0.8
Patch foraging water rate 12 sec	0.0	0.1	0.4	-0.0	0.1	-0.3	0.6
Patch foraging water rate 18 sec	0.5	1.1	2.5	-1.6	-1.2	0.8	-0.4
Patch foraging water rate 24 sec	0.0	0.1	0.2	0.1	-0.0	-0.3	0.4
Patch foraging water rate 6 sec	0.3	0.4	1.2	-1.1	-0.6	0.2	0.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.0	0.3	-0.1	0.5
Distance traveled before self-admin	0.1	0.2	0.6	-0.2	-0.7	0.3	0.0
Distance traveled after self-admin	0.5	0.9	1.4	0.4	1.0	-1.2	1.0
Extensor digitorum longus weight	2.2	8.6	11.5	-3.3	-3.4	3.0	-1.7
Bone: elastic displacement	1.6	2.0	4.3	-2.1	-1.1	1.0	-1.2
Bone: elastic work	0.7	0.9	3.3	-1.8	-0.4	0.4	-0.4
Bone: endosteal estimation	0.1	0.3	0.7	-0.6	-0.8	0.5	0.0
Bone: endosteal perimeter	0.0	0.1	0.4	-0.1	-0.6	0.3	0.1
Epididymis fat weight	8.0	40.4	51.6	7.2	6.0	-6.7	5.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.3	0.6	-0.2	0.1
Delta time in open arm before/after self-admin	0.2	0.3	0.5	0.6	-0.7	0.3	0.4
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	0.4	0.2	-0.0	0.2
Delay discount exponential model param	0.1	0.1	0.2	0.1	0.2	-0.4	0.2
Extinction: sum of active levers before priming	0.3	0.4	0.9	-0.2	-0.7	0.9	-0.3
Active lever presses in extinction session 6	2.1	2.1	3.6	-0.8	-1.8	1.9	-1.0
Bone: final force	0.1	0.2	0.6	0.0	-0.1	0.1	0.8
Bone: final moment	0.1	0.1	0.5	-0.1	0.1	-0.0	0.7
Food consumed during 24 hour testing period	0.1	0.2	0.5	0.5	-0.1	-0.2	0.7
Glucose	0.7	1.1	2.0	0.6	1.4	-1.2	0.9
Heart weight	1.2	1.9	3.2	1.5	1.8	-1.3	0.7
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.1
Intermittent access intake day 1-15 change	0.3	1.8	5.6	-2.4	-0.7	0.3	-0.9
Intermittent access intake escalation	0.2	1.2	4.3	-2.1	-0.2	-0.2	-0.7
Intermittent access intake escalation 2	0.5	0.8	2.7	-1.6	0.4	-0.7	-0.2
Intermitt. access day 1 inactive lever presses	0.1	1.1	2.5	-0.3	-1.3	1.6	-0.2
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.9	-0.9	-0.9	1.4	-0.2
Intermitt. access escalation Index	1.8	5.8	10.5	1.9	3.2	-2.7	1.3
Intermittent access day 1 total infusions	0.6	1.9	4.1	-0.4	-1.3	2.0	-1.2
Intermittent access day 15 total infusions	0.9	2.2	3.5	-1.9	-1.3	1.4	-1.2
Intermittent access terminal intake (last 3 days)	1.5	2.6	4.3	-2.1	-1.4	1.7	-1.2
Intermittent access total infusions	3.1	3.6	5.1	-1.7	-2.1	2.2	-1.5
Intermittent access day 1 locomotion	1.3	2.3	3.7	-1.0	-1.8	1.9	-1.3
Intermittent access day 15 total locomotion	0.0	0.1	0.2	-0.4	-0.3	0.1	0.3
Intermittent access total locomotion	1.3	1.6	2.8	-1.1	-1.7	1.3	-0.8
Intermittent access standard deviation	0.4	1.9	2.8	-1.7	-1.7	1.3	-0.7
Left kidney weight	0.2	1.4	2.6	-0.3	-1.6	1.5	-1.0
Right kidney weight	0.0	0.2	0.4	0.6	-0.5	0.2	0.4
Cocaine induced anxiety	0.1	0.2	0.7	-0.9	0.3	-0.1	-0.2
Post-drug Anxiety	1.4	1.6	2.0	1.4	1.2	-1.3	1.1
Baseline Anxiety	2.0	3.3	6.3	2.5	1.3	-1.7	1.6
Tail length	0.1	0.3	1.2	-1.1	0.1	-0.3	-0.1
Length with tail	0.1	0.3	0.7	-0.5	-0.9	-0.3	0.5
Length without tail	0.2	1.2	4.0	-0.2	-2.0	0.8	0.3
Times rat made contact with spout	1.2	1.3	2.7	-1.3	-1.7	0.9	-0.3
Lifetime Intake	3.3	4.1	5.5	-1.9	-2.2	2.3	-1.5
Liver weight, left	1.5	2.6	3.4	0.9	1.8	-1.8	1.7
Liver weight, right	2.3	3.9	5.7	1.8	1.7	-2.0	2.4
Locomotor activity	0.7	1.1	2.3	1.4	0.1	-0.4	1.5
Locomotor testing distance	0.3	0.7	1.3	1.1	0.2	-0.3	1.1
Locomotor testing rearing	0.2	0.7	1.4	-0.2	-1.2	1.1	0.2
Locomotion in novel chamber	0.4	0.5	0.7	0.7	-0.8	0.4	0.8
Locomotion in novel chamber post-restriction	0.9	2.7	4.2	1.3	2.0	-2.1	1.0
Fecal boli incidents, locomotor time 1	0.8	2.2	2.8	-1.6	-1.6	1.7	-0.8
Change in fecal boli incidents, locomotor task	3.0	3.2	5.6	1.3	2.4	-2.2	0.7
Time >=10cm from walls, locomotor time 1	0.5	0.7	1.1	-0.6	-1.1	0.7	-0.8
Bouts of movement, locomotor time 1	0.3	0.4	0.9	0.8	0.2	-0.1	0.9
Total resting periods, locomotor time 1	0.2	0.3	0.5	0.7	0.1	-0.1	0.7
Rest time, locomotor task time 1	0.8	1.3	2.2	0.6	1.3	-0.8	1.5
Distance moved, locomotor task time 1	0.0	0.1	0.4	-0.1	-0.7	0.1	-0.3
Vertical activity count, locomotor time 1	0.0	0.3	0.5	-0.7	-0.5	-0.1	-0.7
Time >=10cm from walls, locomotor time 2	0.7	2.0	5.1	-2.3	-0.7	1.1	-1.0
Bouts of movement, locomotor time 2	0.3	0.9	1.2	1.1	0.7	-0.8	1.1
Total resting periods, locomotor time 2	0.3	1.1	1.7	1.2	0.9	-0.8	1.3
Rest time, locomotor task time 2	0.1	0.2	0.6	0.5	0.1	0.0	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.9	-1.0	0.1	-0.0	-0.2
Vertical activity count, locomotor time 2	0.2	0.5	1.3	-1.1	0.5	0.1	-0.7
Light reinforcement 1	0.1	0.5	0.7	-0.8	-0.4	0.8	-0.8
Light reinforcement 2	0.6	1.4	3.2	-1.8	-0.2	0.8	-1.3
Bone: marrow area	0.1	0.4	0.7	-0.7	-0.9	0.5	0.1
Bone: maximum diameter	0.0	0.1	0.1	-0.2	-0.3	0.1	0.3
Bone: maximum force	0.1	0.2	0.6	-0.2	-0.3	0.2	0.8
Bone: maximum moment	0.1	0.2	0.5	-0.3	-0.2	0.2	0.7
Mean time between licks in bursts	0.4	2.2	2.7	1.6	1.6	-1.3	1.3
Mean num. licks in bursts	0.8	2.2	4.7	-2.2	-1.2	1.1	-1.1
Cd content in liver	0.0	0.0	0.1	0.2	-0.0	-0.3	0.1
Co content in liver	5.1	6.0	7.8	-1.8	-2.8	2.6	-2.5
Cu content in liver	0.8	0.9	1.6	0.7	-0.8	1.0	-1.3
Fe content in liver	2.4	3.0	5.2	-1.6	-2.3	1.6	-1.3
K content in liver	0.5	0.5	1.5	1.2	0.3	-0.2	0.5
Mg content in liver	0.1	0.1	0.4	0.6	0.4	0.1	-0.2
Mn content in liver	0.6	0.6	0.7	0.7	0.8	-0.8	0.8
Na content in liver	1.4	1.6	2.9	-1.7	-0.9	1.4	-0.9
Rb content in liver	0.2	0.3	0.7	0.8	0.4	-0.2	-0.4
Se content in liver	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.1
Sr content in liver	0.2	0.2	0.6	-0.8	-0.5	0.0	-0.1
Zn content in liver	1.0	1.2	3.8	1.9	0.8	-0.5	-0.2
Bone: minimum diameter	0.5	0.9	1.8	1.3	0.2	-0.6	1.2
Time in familiar zone, hab. session 1	0.7	0.8	1.3	1.2	0.7	-0.6	1.0
Time in novel zone, hab. session 1	0.1	0.2	0.3	0.0	0.3	-0.6	0.4
Total zone transitions, hab. session 1	0.3	0.4	1.3	-0.4	-1.1	0.5	0.3
Total locomotion distance, hab. session 1	0.7	1.0	2.3	-0.9	-1.5	0.9	-0.5
Locomotion velocity, hab. session 1	1.1	1.6	2.7	-1.1	-1.6	1.2	-0.9
Time in familiar zone, hab. session 2	0.5	0.6	1.1	-0.0	1.0	-0.7	1.0
Time in novel zone, hab. session 2	0.1	0.2	0.3	0.4	-0.4	0.1	-0.6
Total zone transitions, hab. session 2	0.2	0.3	0.7	-0.1	-0.5	-0.4	0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.1	-0.5	-0.5	0.6
Locomotion velocity, hab. session 2	0.2	0.2	0.5	0.1	-0.7	-0.3	0.5
Novel to familiar place preference ratio	0.3	0.4	0.6	0.6	0.1	-0.7	0.8
Novelty place preference	0.5	0.7	1.1	1.0	0.2	-0.8	1.0
Time in novel zone, NPP test	0.5	0.6	1.0	1.0	0.0	-0.7	1.0
Total zone transitions, NPP test	0.9	1.4	3.3	-0.6	-1.8	1.3	-0.3
Total locomotion distance, NPP test	1.4	1.9	4.4	-0.8	-2.1	1.4	-0.8
Locomotion velocity, NPP test	1.6	2.3	4.3	-1.3	-2.1	1.6	-1.0
Intraocular pressure	2.4	3.9	5.8	2.0	2.2	-2.4	0.9
Delta distance traveled before/after self-admin	2.3	2.5	3.9	1.4	2.0	-1.6	1.2
Delta ambulatory time before/after self-admin	0.5	0.9	2.1	0.4	1.4	-0.9	0.6
Parametrial fat weight	18.3	43.0	48.2	6.9	6.9	-6.3	6.1
Pavlov. Cond. lever latency	0.6	0.7	1.2	0.3	1.1	-1.1	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.4	-0.6	0.2	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	-0.4	0.4	-0.2
Pavlov. Cond. index score	0.2	0.3	0.5	0.3	-0.7	0.6	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.4	0.2	-0.7	0.5	-0.3
Pavlov. Cond. lever contacts	0.6	0.7	1.3	-0.1	-1.0	1.1	-0.7
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	-0.3	0.9	-0.4	-0.1
Pavlov. Cond. intertrial magazine entries	2.0	2.4	4.3	-1.4	-1.0	1.4	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.0	0.1	-1.0	1.0	-0.7
Pavlov. Cond. response bias	0.8	0.9	1.7	-0.2	-1.3	1.3	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.4	0.5	-0.7	0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	0.3	-0.2	0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.2	0.3	0.1
Pavlov. Cond. index score	0.1	0.2	0.4	-0.6	-0.4	0.5	-0.2
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.6	-0.3	0.5	-0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.4	-0.2	-0.4	0.6	-0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.3
Pavlov. Cond. intertrial magazine entries	0.9	1.9	3.8	0.5	1.0	-2.0	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	-0.5	-0.1	0.2	0.1
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.4	-0.6	0.8	-0.5
Time in closed arm before self-admin	0.1	0.2	0.5	0.1	-0.7	-0.3	0.3
Time in closed arm after self-admin	0.3	0.3	0.5	0.6	-0.2	-0.6	0.7
Time in open arm before self-admin	0.1	0.1	0.2	0.2	0.4	-0.0	0.1
Time in open arm after self-admin	0.0	0.0	0.1	0.0	-0.0	0.3	0.1
Bone: periosteal estimation	0.2	0.4	0.9	-0.4	-0.9	0.6	0.3
Bone: periosteal perimeter	0.0	0.1	0.1	-0.0	-0.4	0.2	0.3
Bone: post-yield work	1.3	2.2	3.1	-1.7	-1.8	1.6	-0.5
Progressive ratio test 1 active lever presses	1.2	2.1	3.9	-0.7	-1.7	2.0	-1.0
Progressive ratio test 1 breakpoint	1.2	2.0	4.0	-0.7	-1.6	2.0	-1.0
Progressive ratio test 1 inactive lever presses	1.6	4.1	7.5	-1.3	-2.3	2.7	-1.4
Progressive ratio test 2 active lever presses	2.2	3.1	4.7	-2.2	-1.9	1.7	-1.2
Progressive ratio test 2 breakpoint	2.2	2.8	4.4	-2.1	-1.7	1.6	-1.1
Progressive ratio test 2 inactive lever presses	1.0	3.3	6.5	-2.5	-1.8	1.8	-0.8
Incentive Sensitization - Responses	1.0	2.8	6.0	-2.5	-1.5	1.3	-1.1
Incentive Sensitization - Breakpoint	1.0	2.2	5.4	-2.3	-1.2	1.1	-0.9
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.5	0.3	-0.3	0.2
Progressive ratio	0.0	0.1	0.2	-0.2	-0.5	0.2	0.3
Food seeking constrained by brief footshock	13.5	16.8	20.8	-3.3	-4.5	4.6	-3.9
Seeking ratio, punishment vs. effort	0.7	1.6	2.6	-1.1	-1.0	1.3	-1.6
Retroperitoneal fat weight	26.5	118.7	135.9	11.7	11.2	-11.2	9.3
Reaction time number correct	0.2	0.6	1.2	-0.8	-1.1	0.5	-0.6
Reaction time mean minus median	0.0	0.2	0.5	0.5	-0.1	0.0	-0.7
Reaction time mean minus median AUC	0.0	0.2	0.8	0.9	0.1	-0.3	-0.1
Reaction time num false alarms	1.3	2.1	4.2	2.0	0.8	-1.2	1.5
Reaction time num false alarms AUC	1.0	2.2	4.2	2.1	0.8	-1.2	1.5
Reaction time trials correct on left	0.2	0.6	1.2	-0.8	-1.1	0.5	-0.6
Reaction time trials on left	0.2	0.6	1.2	-0.7	-1.1	0.5	-0.6
Reaction time mean	0.2	0.4	0.6	0.7	0.7	-0.4	-0.8
Reaction time mean AUC	0.1	0.3	0.5	0.6	0.4	-0.2	-0.7
Median of all reaction times	0.2	0.3	0.6	0.3	0.8	-0.3	-0.7
Reaction time omissions	0.6	1.0	3.6	1.9	-0.5	0.0	0.1
Reaction time false alarm rate	2.2	3.0	4.7	2.2	1.4	-1.5	1.8
Reaction time premature initiation rate	0.0	0.1	0.2	-0.2	0.1	-0.4	0.2
Reaction time premature initiations	0.0	0.1	0.4	-0.6	-0.3	-0.1	-0.2
Std. dev. reaction times	0.1	0.5	1.3	1.1	0.3	-0.5	-0.5
Reaction time trials completed	0.2	0.6	1.2	-0.7	-1.1	0.5	-0.6
Reaction time trials AUC	0.2	0.6	1.2	-0.7	-1.1	0.6	-0.7
Run reversals in cocaine runway, females	0.5	0.6	1.3	-0.6	-0.6	0.6	-1.2
Run reversals in cocaine runway, males	0.7	0.7	1.5	-1.2	-0.9	0.8	0.1
Latency to leave start box in cocaine runway	0.2	0.3	0.8	-0.9	0.0	0.6	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.2	0.5	0.1	0.4
Latency to leave start box in cocaine runway, M	0.6	0.5	1.2	-1.1	-0.4	0.7	-0.5
Std. dev. time between licks in bursts	0.5	1.0	1.8	1.4	0.8	-0.9	0.8
Total sessions with >9 infusions	2.1	2.6	3.4	-1.8	-1.9	1.6	-1.1
Short access day 1 total inactive lever presses	2.0	4.0	5.0	-2.2	-1.9	2.2	-1.6
Short access day 10 total inactive lever presses	0.1	0.4	1.1	-0.3	-0.5	1.1	-0.4
Short access day 1 total infusions	1.8	3.7	4.2	-2.0	-1.9	2.1	-1.6
Short access day 10 total infusions	1.8	2.9	4.7	-1.6	-1.4	2.2	-1.6
Short access total infusions	1.5	2.2	3.2	-1.4	-1.5	1.8	-1.2
Short access day 1 locomotion	1.9	3.2	5.7	-1.4	-2.4	1.9	-1.2
Short access day 10 total locomotion	0.5	1.9	2.4	-1.4	-1.5	1.6	-0.9
Short access total locomotion	1.0	1.5	2.4	-1.2	-1.6	1.4	-0.5
One hour access (0.3 mA shock)	3.0	3.5	10.3	-3.2	-1.4	1.1	-0.7
Compulsive drug intake	2.4	3.6	6.3	0.5	2.5	-2.3	1.6
One hour access (shock baseline)	2.5	6.7	8.4	-2.9	-2.8	2.5	-1.9
Social response proportion	0.2	0.2	1.0	-1.0	0.1	-0.0	-0.1
Social responses	0.2	0.3	0.6	0.2	0.5	-0.5	0.7
Social time	0.1	0.2	0.5	-0.4	0.1	0.1	-0.7
Soleus weight	2.4	7.1	8.5	-2.9	-2.8	2.7	-2.1
Bone: stiffness	0.3	0.5	1.0	1.0	0.5	-0.1	0.8
Tibialis anterior weight	0.7	2.6	4.2	-2.1	-1.8	1.5	-0.7
Time to tail flick, vehicle, before self-admin	0.5	0.7	1.4	0.9	-1.2	0.6	-0.5
Time to tail flick, vehicle, after self-admin	1.9	3.9	5.3	2.3	1.7	-2.2	1.7
Time to tail flick, test, before self-admin	0.8	0.9	2.5	-0.7	-1.6	0.7	-0.1
Time to tail flick, test, after self-admin	0.9	0.9	1.7	-0.9	-0.9	1.3	-0.5
Delta time to tail flick, vehicle, before/after SA	2.1	2.3	3.4	1.1	1.8	-1.6	1.3
Delta time to tail flick, test, before/after SA	1.2	1.4	2.5	-1.6	-0.2	1.3	-1.2
Tibia length	0.6	1.7	4.1	0.4	0.8	-1.4	2.0
Ambulatory time before self-admin	0.1	0.2	0.7	-0.2	-0.8	0.4	0.0
Ambulatory time after self-admin	0.3	0.5	0.9	0.4	0.9	-0.7	0.6
Bone: tissue strength	0.8	0.8	1.9	0.5	1.4	-0.9	0.7
Total heroin consumption	2.4	2.8	5.3	-2.3	-1.3	1.2	-1.6
Bone: trabecular number	1.9	3.6	4.7	-2.2	-1.9	1.9	-1.6
Bone: trabecular spacing	0.7	1.0	1.4	1.2	0.7	-0.9	1.1
Bone: trabecular thickness	0.4	0.6	0.7	-0.8	-0.7	0.9	-0.8
Bone: trabecular tissue density	0.1	0.2	0.3	-0.2	-0.5	0.5	-0.5
Water consumed over 24 hours	0.2	0.4	0.7	0.7	-0.4	-0.4	0.9
Number of responses in last shaping day	1.4	1.8	3.2	-1.1	-1.0	1.4	-1.8