Xylt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	Xylt1	0.58	0.14	9.9e-09	0.19	0.21	0.2	0.19	3.0e-05	1.2e-05	2.0e-05	2.4e-05
2	IL	gene expression	Xylt1	0.22	0.14	2.2e-03	0.05	0.04	0.02	0.04	2.0e-02	5.2e-02	9.7e-02	3.7e-02
3	Adipose	mRNA stability	Xylt1	0.06	0.04	1.0e-02	0.01	0.01	0	0.01	8.4e-03	3.1e-02	9.8e-02	1.6e-02
4	RMTg	gene expression	Xylt1	0.11	0.07	9.3e-03	0.09	0.05	-0.01	0.06	2.1e-03	2.0e-02	4.8e-01	1.4e-02
5	Brain	mRNA stability	Xylt1	0.06	0.04	9.0e-05	0.02	0.03	0.03	0.02	5.4e-03	1.6e-03	1.5e-03	5.1e-03
6	Adipose	gene expression	Xylt1	0.16	0.07	6.6e-06	0.03	0.04	0.04	0.04	1.2e-04	1.8e-05	2.2e-05	1.9e-05
7	Brain	gene expression	Xylt1	0.21	0.1	1.5e-06	0.08	0.07	0.07	0.08	5.9e-08	2.2e-07	3.6e-07	8.9e-08
8	NAcc	gene expression	Xylt1	0.17	0.08	8.9e-07	0.02	0.05	0.05	0.05	1.2e-03	7.0e-07	2.5e-06	4.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.6	1.1	2.6	-1.3	0.3	-1.6	-0.4	-0.6	1.5	1.2	-0.5
Area under the delay curve	0.6	0.6	1.3	0.3	-0.5	0.4	1.1	0.7	0.8	0.9	-1.0
BMI with tail	3.3	10.8	23.5	-4.2	4.9	-3.0	-4.0	-4.0	0.9	-0.4	1.9
BMI without tail	7.7	15.8	29.5	-5.0	4.8	-3.7	-5.4	-5.1	0.5	-0.3	3.0
Body weight	2.7	11.4	22.0	-4.7	4.2	-3.8	-3.9	-3.7	2.4	0.9	0.9
Weight adjusted by age	0.8	1.0	4.1	-0.2	0.7	-0.0	-0.5	-0.9	-0.7	-2.0	1.2
Bone surface	0.4	0.8	1.8	-1.3	0.8	-1.1	-1.0	-1.0	0.6	0.6	0.3
Bone volume	0.7	1.2	2.6	-1.5	0.7	-1.6	-0.8	-0.9	1.2	1.1	-0.2
Breakpoint value in progressive ratio session	2.4	2.6	5.9	2.4	-2.4	1.0	2.1	1.8	-0.5	-0.8	-0.5
Number of licking bursts	4.9	5.7	9.9	3.1	-2.7	2.8	3.1	2.9	-0.8	-0.3	-1.5
Context. condit. distance diff. score	0.4	0.5	1.1	0.8	-1.1	0.4	0.9	0.4	-0.2	-0.8	0.2
Locomotion velocity, session 1	0.7	0.8	2.3	0.9	-1.5	0.2	0.7	1.2	-0.1	0.8	-0.7
Locomotion distance, session 1	0.3	0.4	1.2	-0.5	-0.3	-1.1	-0.7	-0.7	0.4	0.1	0.6
Locomotion velocity, session 2	1.3	1.6	3.5	1.4	-1.9	0.7	1.6	1.6	-0.0	0.7	-1.0
Locomotion distance, session 2	0.3	0.5	1.4	-0.7	-0.4	-1.2	-0.7	-0.6	0.4	0.9	0.3
Locomotion velocity, session 3	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.4	-0.0	-0.2	-0.2	0.2
Locomotion distance, session 3	0.4	0.4	1.6	0.4	-0.1	0.7	-0.5	-0.0	-1.3	-0.6	0.7
Stereotopy head waving bouts, day 3	0.4	0.4	1.1	0.6	-0.7	-0.1	1.0	0.7	0.7	-0.0	-0.7
Stereotopy head waving duration, day 3	0.4	0.5	0.9	0.4	-0.5	-0.3	1.0	0.7	0.9	0.2	-0.9
Locomotion velocity, session 7	0.6	0.7	2.3	0.1	-0.0	0.8	-0.2	-0.4	-1.5	-0.8	1.3
Locomotion distance, session 7	0.3	0.4	0.8	0.6	-0.9	0.8	0.5	0.5	-0.9	0.1	0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.0	-0.3	-0.5	0.4	-0.0	0.6	0.3	-0.2
Stereotopy head waving duration, day 7	0.7	0.9	1.7	-1.0	1.0	-1.1	-1.0	-1.3	0.2	-0.1	1.0
Locomotion velocity, session 8	0.6	0.7	2.5	1.0	-1.6	0.2	1.0	1.0	-0.1	0.4	-0.3
Locomotion distance, session 8	0.2	0.4	1.4	0.5	-1.2	-0.3	0.8	0.4	0.4	0.2	-0.1
Degree of sensitization distance	0.9	0.9	2.7	-0.3	-0.4	-0.8	0.9	0.5	1.6	1.1	-1.2
Degree of sensitization stereotypy	0.2	0.2	0.5	-0.4	0.1	-0.5	-0.3	-0.7	-0.0	0.3	0.7
Conditioned locomotion	0.8	0.9	2.0	1.0	-0.5	1.4	-0.2	0.2	-1.4	-1.1	1.0
Cocaine response after cond. corrected	0.2	0.2	0.5	0.3	-0.6	0.5	0.7	0.4	0.1	0.4	-0.3
Cocaine response after cond. not corrected	0.3	0.3	0.7	-0.9	0.6	-0.1	-0.6	-0.7	0.0	0.5	0.3
Cocaine response before conditioning	2.5	3.0	7.3	-2.1	2.3	-1.2	-2.7	-2.0	-0.2	0.3	1.2
Saline control response	0.2	0.2	0.5	-0.6	0.6	-0.3	-0.7	-0.5	0.5	-0.3	0.0
Bone: connectivity density	0.4	0.7	1.4	-1.1	0.8	-0.7	-1.0	-1.2	0.2	0.1	0.7
Bone: cortical apparent density	0.9	1.2	2.4	1.3	-1.6	0.9	1.3	1.5	-0.5	0.1	-0.8
Bone: cortical area	2.0	3.0	5.9	-2.4	1.7	-2.4	-1.8	-1.4	1.7	1.4	-0.4
Bone: cortical porosity	0.9	1.0	1.7	-1.0	1.3	-0.7	-1.3	-1.3	-0.0	-0.5	1.0
Bone: cortical porosity	0.5	0.5	0.9	-0.5	0.8	-0.5	-0.9	-1.0	-0.1	-0.8	0.9
Bone: cortical thickness	1.5	2.4	5.0	-1.6	0.3	-2.2	-0.6	-0.1	2.1	2.1	-1.5
Bone: cortical thickness	1.8	2.1	6.1	-0.8	-0.4	-1.4	0.3	0.6	2.0	2.5	-1.9
Bone: cortical tissue density	0.9	1.2	2.4	1.3	-1.6	0.9	1.2	1.4	-0.5	0.1	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.2	0.1	-0.5	0.0	-0.3	0.3	-0.4	0.1
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.3	-0.8	0.8	-0.6	-0.5	-1.1	0.0	-0.8	0.9
Condit. Reinf. active responses	0.1	0.2	0.5	0.1	0.1	-0.5	0.5	0.2	0.7	-0.2	-0.6
Condit. Reinf. inactive responses	0.3	0.4	1.1	0.5	-0.1	-0.0	0.9	0.7	0.6	0.3	-1.0
Incentive salience index mean	0.2	0.3	0.6	-0.1	0.3	-0.0	-0.5	-0.5	-0.7	-0.8	0.7
Condit. Reinf. lever presses	0.6	0.8	2.8	0.8	0.2	0.9	-0.2	-0.0	-1.7	-1.2	1.0
Condit. Reinf. active minus inactive responses	0.8	1.0	2.2	-1.1	1.5	-1.3	0.2	-1.0	1.3	-0.3	-0.0
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.0	-0.8	1.4	-0.9	0.1	-0.7	0.8	-0.6	0.1
Condit. Reinf. active responses	0.4	0.5	1.5	-0.8	1.2	-0.8	0.1	-0.9	0.7	-0.4	0.2
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.5	0.7	-0.0	-0.5	-0.6	-0.1	0.1	0.4
Condit. Reinf. lever presses	2.1	2.9	5.7	-2.1	2.4	-1.8	-1.7	-2.2	0.7	-0.4	1.1
Condit. Reinf. lever reinforcers received	0.3	0.5	1.5	-0.7	1.2	-0.6	0.1	-0.8	0.6	-0.6	0.3
Conditioned reinforcement - actives	1.3	1.3	5.7	-0.3	-0.9	-0.5	0.3	0.7	1.3	2.4	-1.2
Conditioned reinforcement - inactives	1.6	1.8	3.6	0.8	-1.9	0.6	1.4	1.5	0.7	1.8	-1.4
Conditioned locomotion	0.5	0.6	2.5	0.8	-1.6	0.3	0.7	1.0	-0.2	0.5	-0.4
Patch foraging indifference point 0 sec	0.9	1.5	4.3	-1.5	0.5	-2.1	-0.8	-1.0	1.8	0.6	-0.2
Patch foraging indifference point AUC	0.7	0.9	1.4	-1.2	0.8	-1.1	-0.8	-0.2	1.2	1.0	-0.8
Delay disc. indifference point, 0s delay	0.4	0.4	2.4	-0.2	-0.2	0.2	-0.0	0.3	0.3	1.5	-0.6
Delay disc. indifference point, 16s delay	4.1	4.1	8.8	2.2	-2.5	1.3	3.0	2.5	0.7	0.1	-2.0
Delay disc. indifference point, 2s delay	1.2	1.4	2.9	-1.7	1.1	-1.2	-1.2	-1.2	0.4	1.4	0.5
Delay disc. indifference point, 24s delay	2.6	2.5	4.9	2.0	-1.7	1.9	2.2	1.8	-0.4	-0.2	-0.9
Delay disc. indifference point, 4s delay	1.6	1.7	4.1	-0.1	-0.4	-0.4	1.4	0.9	1.8	2.0	-1.9
Delay disc. indifference point, 8s delay	0.3	0.3	1.1	0.3	-0.8	0.3	0.4	0.6	0.2	1.0	-0.5
Indifference point function ln k	0.1	0.2	0.3	-0.5	0.4	-0.5	-0.3	-0.5	0.2	0.3	0.3
Indifference point function log k	0.1	0.2	0.3	-0.5	0.4	-0.5	-0.3	-0.5	0.2	0.3	0.3
Patch foraging total patch changes 0 sec	1.2	2.0	5.1	-1.8	0.8	-2.3	-1.1	-1.3	1.9	0.5	-0.1
Patch foraging total patch changes 12 sec	0.2	0.3	0.8	-0.6	-0.0	-0.9	-0.7	-0.6	0.4	-0.0	0.3
Patch foraging total patch changes 18 sec	0.2	0.2	0.4	-0.4	-0.3	-0.6	-0.3	0.2	0.6	0.6	-0.5
Patch foraging total patch changes 24 sec	1.4	1.7	4.4	-1.7	0.5	-2.1	-0.9	-0.8	1.8	1.1	-0.6
Patch foraging total patch changes 6 sec	1.4	2.1	6.4	-0.4	-0.9	-1.7	0.7	0.7	2.5	1.5	-1.9
Patch foraging time to switch 0 sec	3.2	5.0	9.2	3.0	-2.3	2.8	1.5	1.6	-2.9	-1.9	1.0
Patch foraging water rate 0 sec	0.5	0.9	1.9	-1.3	1.4	-0.8	-0.8	-1.0	1.1	0.2	-0.1
Patch foraging water rate 12 sec	3.4	5.1	9.7	-3.1	2.9	-2.7	-1.9	-2.1	2.5	1.2	-0.3
Patch foraging water rate 18 sec	0.8	1.0	2.0	-1.3	1.2	-1.3	-0.6	-0.9	1.4	0.1	-0.3
Patch foraging water rate 24 sec	0.6	0.9	1.9	-1.1	0.9	-0.9	-0.1	-0.2	1.4	1.2	-1.0
Patch foraging water rate 6 sec	1.0	1.5	4.0	-1.2	1.1	-1.2	0.0	-0.1	2.0	1.3	-1.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	0.2	0.3	0.1	0.1	-0.0	0.1	-0.2
Distance traveled before self-admin	0.7	0.7	2.0	0.3	-0.5	0.0	0.0	1.2	0.5	1.4	-1.3
Distance traveled after self-admin	0.4	0.5	2.2	-0.6	0.3	-0.4	-0.9	0.1	-0.1	1.5	-0.2
Extensor digitorum longus weight	1.7	6.6	14.3	-3.6	3.3	-1.9	-3.8	-2.6	0.0	1.6	1.0
Bone: elastic displacement	1.1	1.2	3.7	1.1	-1.9	0.0	1.1	1.4	0.4	0.5	-1.0
Bone: elastic work	0.1	0.2	0.6	-0.2	-0.3	-0.8	-0.4	0.0	0.4	0.6	-0.1
Bone: endosteal estimation	1.3	2.9	6.3	-1.8	2.1	-0.8	-2.5	-2.2	-0.6	-0.3	1.8
Bone: endosteal perimeter	0.5	1.1	2.6	-0.9	1.6	0.1	-1.6	-1.1	-0.7	-0.3	1.0
Epididymis fat weight	1.1	2.5	3.9	-2.0	2.0	-1.9	-1.6	-2.0	1.3	-0.2	0.5
Delta time in closed arm before/after self-admin	1.2	1.1	2.9	0.8	-0.3	1.4	0.1	-0.2	-1.7	-1.3	1.3
Delta time in open arm before/after self-admin	3.4	3.3	6.1	-2.4	2.0	-2.5	-1.6	-1.6	1.9	1.3	-0.3
Diff in mean of infusions in LGA sessions	0.7	0.8	1.6	0.7	-0.8	-0.4	1.2	1.0	1.2	0.1	-1.3
Delay discount exponential model param	0.5	0.5	1.3	-0.4	0.5	-0.4	-1.1	-0.6	-0.7	-0.7	0.8
Extinction: sum of active levers before priming	0.7	0.7	1.5	1.2	-1.0	1.0	0.6	1.1	-0.6	-0.2	-0.5
Active lever presses in extinction session 6	0.1	0.1	0.2	0.2	0.1	-0.3	-0.1	0.1	0.4	-0.3	-0.3
Bone: final force	2.0	3.2	6.7	-2.5	1.6	-2.6	-2.1	-1.6	1.1	1.2	0.1
Bone: final moment	1.8	2.9	6.5	-2.4	1.5	-2.6	-2.0	-1.5	1.1	1.1	0.1
Food consumed during 24 hour testing period	0.3	0.4	0.8	-0.7	0.1	-0.8	-0.9	-0.4	0.1	0.8	0.3
Glucose	0.1	0.2	0.7	-0.1	0.0	-0.4	0.5	0.2	0.8	0.0	-0.5
Heart weight	0.7	1.0	2.7	-0.5	0.5	-0.8	0.9	0.3	1.6	1.0	-1.4
Delay discount hyperbolic model param	0.4	0.4	0.9	-0.1	0.3	-0.2	-0.9	-0.4	-0.8	-0.9	0.8
Intermittent access intake day 1-15 change	1.4	1.4	3.2	1.3	-1.1	1.8	1.0	1.5	-0.9	0.6	-0.7
Intermittent access intake escalation	1.1	1.1	2.4	1.1	-0.7	1.6	0.9	1.5	-0.6	0.8	-0.9
Intermittent access intake escalation 2	1.6	1.6	3.9	1.3	-0.6	2.0	1.3	1.7	-0.7	0.6	-1.1
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.9	0.3	-0.4	0.5	0.8	1.0	0.4	1.4	-1.1
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.5	-0.2	-0.6	-0.4	-0.3	0.3	-0.2	0.7	0.1
Intermitt. access escalation Index	0.8	0.7	2.4	-0.9	1.6	-0.2	-1.2	-0.8	-0.2	-0.1	0.4
Intermittent access day 1 total infusions	1.0	1.1	3.5	-1.4	0.5	-1.9	-0.9	-0.9	1.3	0.2	0.1
Intermittent access day 15 total infusions	0.2	0.2	0.5	-0.2	-0.3	-0.4	0.0	0.5	0.7	0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.7	-0.3	-0.3	-0.7	-0.2	0.3	0.8	0.6	-0.7
Intermittent access total infusions	0.7	0.8	2.2	-1.1	0.5	-1.5	-0.7	-0.4	1.3	0.7	-0.4
Intermittent access day 1 locomotion	1.1	1.2	4.2	-1.3	0.3	-2.1	-0.6	-0.7	1.5	0.2	-0.3
Intermittent access day 15 total locomotion	1.0	1.0	3.3	-0.3	-0.2	-1.2	0.6	0.5	1.8	0.8	-1.5
Intermittent access total locomotion	1.0	1.1	4.3	-1.0	0.4	-2.1	-0.3	-0.4	1.6	-0.0	-0.6
Intermittent access standard deviation	0.5	0.5	1.6	-0.2	0.4	0.2	0.5	0.6	0.7	1.2	-1.1
Left kidney weight	3.4	9.6	18.7	-4.3	4.1	-3.4	-3.7	-3.0	2.1	1.6	0.2
Right kidney weight	3.9	11.0	22.2	-4.6	4.7	-3.4	-3.9	-3.3	2.1	1.5	0.3
Cocaine induced anxiety	0.1	0.1	0.6	-0.2	0.7	-0.1	-0.0	0.2	0.1	-0.8	-0.3
Post-drug Anxiety	0.8	0.8	2.5	-0.1	-0.0	-0.4	1.0	0.8	1.4	0.7	-1.6
Baseline Anxiety	1.1	1.2	4.9	0.1	-1.2	-0.2	0.5	0.9	0.8	2.2	-1.2
Tail length	1.9	5.8	11.6	-3.4	2.0	-3.0	-3.0	-2.7	1.7	1.5	0.7
Length with tail	0.7	2.7	5.4	-2.2	0.9	-2.1	-1.2	-1.2	2.3	1.7	-0.6
Length without tail	0.8	1.7	3.7	0.8	-0.9	0.4	1.7	1.6	1.3	0.9	-1.9
Times rat made contact with spout	0.2	0.2	0.7	0.1	-0.5	0.1	-0.2	0.1	-0.8	0.8	0.4
Lifetime Intake	1.3	1.5	3.7	-1.7	0.8	-1.9	-1.2	-0.9	1.4	0.7	-0.1
Liver weight, left	0.6	1.0	2.4	-1.0	1.6	-0.6	-1.2	-1.2	-0.1	-0.9	0.8
Liver weight, right	1.5	2.4	5.4	-1.2	2.3	-0.1	-1.7	-1.8	-0.9	-1.7	1.7
Locomotor activity	0.6	1.0	2.7	-1.0	0.8	-0.7	-1.0	-1.6	0.0	-0.7	1.4
Locomotor testing distance	0.5	0.9	2.0	-1.2	0.5	-1.3	-0.9	-1.4	0.5	0.0	0.9
Locomotor testing rearing	0.5	0.8	1.8	-0.7	1.0	-0.7	-0.4	-1.4	0.2	-0.9	1.1
Locomotion in novel chamber	1.8	2.3	8.4	-1.8	2.9	-1.1	-1.1	-1.7	0.8	-0.6	0.5
Locomotion in novel chamber post-restriction	0.4	0.5	2.3	-0.4	0.3	-0.8	-0.2	-0.6	1.5	-0.3	-0.3
Fecal boli incidents, locomotor time 1	1.3	1.5	5.1	0.8	0.1	1.5	0.3	-0.2	-1.4	-2.2	1.3
Change in fecal boli incidents, locomotor task	3.1	3.0	7.3	-0.5	-0.3	-2.0	0.8	0.8	2.7	2.3	-2.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.7	0.2	-0.7	-0.3	-0.3	0.2	0.0	0.8	-0.1
Bouts of movement, locomotor time 1	1.4	1.6	3.5	1.6	-0.3	1.9	1.3	1.2	-1.0	-1.5	-0.3
Total resting periods, locomotor time 1	2.1	2.3	4.3	2.0	-1.0	2.1	1.5	1.5	-1.2	-1.6	-0.4
Rest time, locomotor task time 1	2.2	2.5	5.0	2.2	-2.0	1.7	1.6	2.0	-1.0	-0.0	-0.8
Distance moved, locomotor task time 1	2.3	2.5	5.6	-2.2	1.3	-2.4	-1.7	-1.8	1.2	0.6	0.5
Vertical activity count, locomotor time 1	1.6	1.7	4.0	-1.6	0.5	-1.8	-1.2	-0.9	0.9	2.0	-0.1
Time >=10cm from walls, locomotor time 2	0.6	0.7	1.6	-0.9	0.4	-1.0	-1.3	-0.4	-0.2	1.2	0.5
Bouts of movement, locomotor time 2	2.6	2.8	6.8	-0.0	0.9	1.1	-1.0	-1.6	-1.9	-2.6	2.5
Total resting periods, locomotor time 2	2.4	2.5	5.8	-0.2	1.0	0.8	-1.1	-1.7	-1.8	-2.4	2.4
Rest time, locomotor task time 2	0.4	0.4	0.8	0.5	-0.9	-0.1	0.7	0.8	0.6	0.6	-0.8
Distance moved, locomotor task time 2	0.3	0.3	1.0	-0.3	-0.5	-0.2	-0.9	0.3	-0.4	1.0	-0.1
Vertical activity count, locomotor time 2	0.9	1.0	4.4	-0.1	-1.0	-0.6	-0.2	0.8	0.5	2.1	-1.0
Light reinforcement 1	0.4	0.8	1.7	1.2	-1.3	0.7	1.0	0.6	-0.3	-1.0	0.1
Light reinforcement 2	0.1	0.1	0.3	0.3	-0.5	-0.3	0.3	0.2	0.3	-0.1	-0.0
Bone: marrow area	1.3	2.7	5.9	-1.7	2.0	-0.7	-2.4	-2.1	-0.6	-0.3	1.8
Bone: maximum diameter	1.4	2.5	5.1	-2.1	2.2	-1.5	-2.2	-1.7	0.6	0.3	0.6
Bone: maximum force	1.8	3.0	6.0	-2.4	1.5	-2.4	-2.2	-1.6	1.1	1.3	0.3
Bone: maximum moment	1.5	2.7	5.6	-2.2	1.4	-2.4	-2.0	-1.5	1.1	1.1	0.3
Mean time between licks in bursts	0.3	0.5	1.2	0.3	0.4	1.1	0.1	-0.2	-0.8	-1.1	0.7
Mean num. licks in bursts	3.9	4.7	9.1	-2.8	2.0	-2.5	-3.0	-2.5	0.3	1.0	1.5
Cd content in liver	0.7	0.8	1.7	1.3	-0.6	1.0	1.3	0.7	-0.4	-0.9	0.1
Co content in liver	1.4	1.7	3.3	0.3	-1.0	-1.0	1.3	1.3	1.6	1.5	-1.8
Cu content in liver	0.6	0.8	2.1	-0.9	0.6	-1.5	0.1	-0.5	1.3	0.8	-0.4
Fe content in liver	2.1	2.6	5.0	1.0	-1.5	-0.1	1.9	2.1	1.2	1.6	-2.2
K content in liver	0.2	0.2	0.6	-0.1	0.7	0.1	-0.2	-0.3	-0.4	-0.8	0.3
Mg content in liver	0.9	0.9	3.5	0.2	0.5	0.4	-0.4	-0.7	-1.0	-1.9	1.3
Mn content in liver	0.5	0.6	1.3	-0.2	0.7	0.5	-0.8	-0.6	-1.1	-0.7	0.9
Na content in liver	1.7	1.8	3.6	-0.9	1.2	-0.0	-1.8	-1.5	-1.5	-0.6	1.9
Rb content in liver	0.5	0.6	1.6	0.0	-0.1	-0.8	1.1	0.2	1.3	-0.4	-0.8
Se content in liver	0.0	0.1	0.2	-0.0	0.3	0.4	-0.1	-0.1	-0.4	0.1	0.2
Sr content in liver	2.0	1.8	4.0	-1.0	1.7	0.3	-2.0	-1.5	-0.9	-1.0	1.5
Zn content in liver	2.3	2.6	5.0	-1.8	1.3	-1.4	-2.1	-2.2	-0.5	-0.2	2.0
Bone: minimum diameter	0.7	1.3	2.8	-1.5	1.4	-1.0	-1.7	-1.3	0.1	0.2	0.8
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.2	-0.8	-0.4	0.5	0.5	0.6	0.6	-0.6
Time in novel zone, hab. session 1	0.5	0.5	1.2	-0.4	0.4	0.1	-0.7	-0.9	-0.6	-0.6	1.1
Total zone transitions, hab. session 1	1.2	1.7	4.9	-1.3	-0.2	-2.2	-0.8	-0.4	1.8	1.6	-0.8
Total locomotion distance, hab. session 1	2.9	4.1	11.0	-2.4	0.7	-3.3	-1.6	-1.3	2.5	2.3	-0.5
Locomotion velocity, hab. session 1	2.2	3.1	8.8	-2.1	0.7	-3.0	-1.4	-1.3	2.2	1.7	-0.3
Time in familiar zone, hab. session 2	0.4	0.4	0.9	-1.0	0.6	-0.7	-0.6	-0.8	0.5	0.5	0.4
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	0.0	0.1	-0.2	-0.0	-0.2	-0.4	0.0
Total zone transitions, hab. session 2	1.0	1.3	4.5	-1.2	0.2	-2.1	-0.9	-0.8	1.3	0.9	-0.0
Total locomotion distance, hab. session 2	1.3	1.7	4.8	-1.3	-0.1	-2.2	-0.7	-0.5	1.6	1.8	-0.5
Locomotion velocity, hab. session 2	1.2	1.7	5.0	-1.3	-0.0	-2.2	-1.0	-0.6	1.5	1.7	-0.3
Novel to familiar place preference ratio	0.9	0.9	2.1	0.6	-1.1	-0.0	1.5	1.0	0.8	0.8	-1.2
Novelty place preference	1.4	1.4	3.0	0.8	-1.4	0.2	1.7	1.4	0.8	1.0	-1.5
Time in novel zone, NPP test	1.2	1.2	2.6	0.7	-1.4	-0.0	1.6	1.2	0.9	0.9	-1.3
Total zone transitions, NPP test	0.5	0.7	1.9	-1.0	0.1	-1.4	-0.9	-0.6	0.7	0.9	0.0
Total locomotion distance, NPP test	0.8	1.1	3.3	-0.8	-0.1	-1.4	-0.3	0.0	1.3	1.8	-0.9
Locomotion velocity, NPP test	0.7	0.9	3.0	-0.6	0.1	-1.2	-0.2	0.2	1.2	1.7	-1.0
Intraocular pressure	0.3	0.4	1.1	-0.8	1.0	-0.7	-0.5	-0.5	0.3	0.2	0.1
Delta distance traveled before/after self-admin	0.8	0.9	1.7	-1.1	0.8	-0.7	-1.1	-1.3	-0.4	-0.3	1.2
Delta ambulatory time before/after self-admin	0.5	0.6	1.1	-1.0	0.5	-0.7	-0.8	-1.1	-0.4	0.2	1.0
Parametrial fat weight	3.9	7.7	15.0	-3.9	3.8	-3.0	-3.1	-2.9	2.1	0.7	0.3
Pavlov. Cond. lever latency	2.8	3.6	6.9	0.2	-1.7	-0.9	1.8	1.6	2.6	2.3	-2.6
Pavlov. Cond. magazine entry latency	4.4	5.7	9.5	-1.6	3.0	-0.0	-2.6	-2.8	-2.1	-2.4	3.1
Pavlov. Cond. change in total contacts	3.5	3.7	8.9	-0.0	1.8	1.6	-1.4	-1.4	-3.0	-2.1	2.6
Pavlov. Cond. index score	4.5	5.7	10.6	-0.7	2.5	0.9	-2.3	-2.3	-2.9	-2.9	3.3
Pavlov. Cond. latency score	3.8	4.8	8.3	-0.8	2.4	0.6	-2.3	-2.2	-2.5	-2.6	2.9
Pavlov. Cond. lever contacts	4.1	4.8	9.0	-0.4	2.2	0.9	-2.0	-2.0	-2.9	-2.6	3.0
Pavlov. Cond. magazine entry number	3.8	4.8	9.4	0.7	-2.2	-1.0	2.0	2.1	2.8	2.5	-3.1
Pavlov. Cond. intertrial magazine entries	1.7	2.1	5.0	0.3	-1.0	-0.8	1.5	1.3	2.2	1.2	-2.2
Pavlov. Cond. lever-magazine prob. diff.	5.4	6.7	12.8	-0.9	2.8	0.8	-2.6	-2.6	-3.0	-3.0	3.6
Pavlov. Cond. response bias	4.4	5.4	11.2	-0.2	2.0	1.4	-1.9	-1.9	-3.3	-2.8	3.3
Pavlov. Cond. lever latency	2.0	2.7	4.8	2.1	-2.2	1.8	1.6	2.1	-0.9	-0.1	-1.0
Pavlov. Cond. magazine entry latency	1.1	1.2	3.1	1.0	0.3	1.8	0.2	0.1	-1.7	-1.4	0.9
Pavlov. Cond. change in total contacts	1.0	1.3	3.4	-1.2	1.4	-1.7	0.2	-0.9	1.9	0.2	-0.4
Pavlov. Cond. index score	0.5	0.7	2.1	-0.7	1.4	-0.3	-0.6	-1.1	-0.1	-0.6	0.8
Pavlov. Cond. latency score	0.5	0.6	1.9	-0.7	1.4	-0.2	-0.7	-1.0	-0.3	-0.5	0.9
Pavlov. Cond. lever contacts	2.8	3.9	8.1	-2.5	2.8	-1.9	-2.0	-2.6	0.9	-0.3	1.3
Pavlov. Cond. magazine entry number	0.6	0.8	1.5	-1.2	0.4	-1.2	-1.0	-0.6	0.9	1.0	-0.2
Pavlov. Cond. intertrial magazine entries	2.1	2.7	5.3	-2.3	2.2	-1.4	-2.0	-2.2	0.7	-0.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.1	-0.5	1.5	-0.0	-0.6	-1.0	-0.3	-0.8	1.0
Pavlov. Cond. response bias	1.0	1.4	4.2	-1.2	2.0	-0.8	-1.0	-1.6	0.2	-0.7	1.0
Time in closed arm before self-admin	0.8	0.9	1.7	-1.3	0.8	-1.3	-0.6	-0.8	1.2	1.0	-0.3
Time in closed arm after self-admin	0.7	0.8	1.8	0.6	-0.7	0.2	1.4	1.0	0.9	0.5	-1.2
Time in open arm before self-admin	2.0	2.2	4.8	2.0	-1.0	2.2	1.4	1.5	-1.2	-1.3	-0.4
Time in open arm after self-admin	1.0	1.1	3.4	-1.2	1.6	-0.6	-1.9	-0.9	-0.1	0.4	0.4
Bone: periosteal estimation	1.8	3.8	7.1	-2.6	2.5	-1.9	-2.7	-2.2	0.7	0.7	0.9
Bone: periosteal perimeter	1.2	2.0	4.7	-1.8	2.2	-1.1	-1.9	-1.7	0.4	-0.2	0.7
Bone: post-yield work	3.6	5.0	9.5	-2.3	2.5	-1.7	-2.8	-3.1	-0.2	-1.5	2.5
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	-0.7	0.2	-0.9	-0.1	-0.5	0.7	-0.3	-0.0
Progressive ratio test 1 breakpoint	0.3	0.3	0.8	-0.8	0.4	-0.9	-0.2	-0.6	0.7	-0.3	0.0
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.4	-1.2	0.4	-1.1	-0.8	-1.1	0.4	0.1	0.7
Progressive ratio test 2 active lever presses	0.3	0.4	1.2	-0.7	0.2	-1.1	-0.6	-0.5	0.7	0.0	0.1
Progressive ratio test 2 breakpoint	0.3	0.3	1.1	-0.7	0.2	-1.0	-0.5	-0.6	0.6	-0.2	0.3
Progressive ratio test 2 inactive lever presses	0.2	0.2	1.2	-0.4	-0.3	-1.1	-0.1	-0.1	0.7	-0.1	-0.1
Incentive Sensitization - Responses	0.4	0.5	1.5	0.1	-0.3	-0.3	-0.4	-0.6	-0.7	-0.9	1.2
Incentive Sensitization - Breakpoint	0.4	0.4	1.5	0.1	-0.3	-0.4	-0.5	-0.6	-0.7	-0.8	1.2
Sum of active levers in priming session hrs 5-6	0.5	0.4	1.8	0.4	0.3	0.1	-0.5	-0.3	-0.6	-1.3	0.9
Progressive ratio	0.3	0.4	1.3	-0.2	-0.0	-0.7	0.3	0.2	1.1	0.6	-0.8
Food seeking constrained by brief footshock	0.7	0.9	1.8	1.0	-0.9	0.7	1.1	1.3	0.2	0.5	-1.0
Seeking ratio, punishment vs. effort	0.3	0.4	1.3	0.1	-0.1	0.6	-0.4	-0.3	-1.2	-0.6	1.0
Retroperitoneal fat weight	1.1	3.6	8.2	-2.2	2.9	-2.2	-0.7	-1.5	2.7	-0.3	-0.9
Reaction time number correct	0.3	0.4	2.2	0.4	0.1	0.7	0.4	-0.2	-0.3	-1.5	0.4
Reaction time mean minus median	0.2	0.3	0.6	-0.7	0.7	-0.5	-0.8	-0.5	0.1	0.4	0.2
Reaction time mean minus median AUC	0.2	0.2	0.4	-0.6	0.6	-0.6	-0.4	-0.4	0.4	-0.0	0.0
Reaction time num false alarms	1.3	1.8	3.5	1.1	-1.2	1.2	1.6	1.9	0.2	1.0	-1.8
Reaction time num false alarms AUC	0.9	1.2	2.4	1.1	-1.1	1.2	1.2	1.5	-0.1	0.4	-1.3
Reaction time trials correct on left	0.3	0.4	2.2	0.4	0.1	0.7	0.4	-0.2	-0.3	-1.5	0.4
Reaction time trials on left	0.3	0.4	2.4	0.3	0.1	0.7	0.3	-0.3	-0.3	-1.5	0.5
Reaction time mean	0.5	0.7	1.3	-1.1	0.7	-1.0	-1.1	-1.0	0.1	0.4	0.6
Reaction time mean AUC	0.3	0.4	1.0	-0.7	0.5	-0.6	-1.0	-0.8	-0.2	0.0	0.7
Median of all reaction times	0.5	0.6	1.4	-0.9	0.5	-1.0	-1.2	-1.0	-0.1	0.3	0.8
Reaction time omissions	0.9	1.2	3.2	0.1	0.6	0.6	-0.9	-1.0	-1.3	-1.6	1.8
Reaction time false alarm rate	0.9	1.3	2.5	0.9	-1.2	0.9	1.0	1.6	-0.1	1.3	-1.4
Reaction time premature initiation rate	0.2	0.3	1.1	-0.6	0.2	-0.3	-1.0	-0.4	-0.5	0.7	0.5
Reaction time premature initiations	0.1	0.2	0.6	-0.1	0.1	0.4	-0.6	-0.3	-0.8	-0.3	0.6
Std. dev. reaction times	0.5	0.7	1.4	-1.2	0.9	-1.1	-1.0	-0.9	0.6	0.4	0.1
Reaction time trials completed	0.3	0.4	2.4	0.3	0.1	0.7	0.3	-0.3	-0.3	-1.5	0.5
Reaction time trials AUC	0.2	0.3	1.7	0.1	0.3	0.5	0.2	-0.4	-0.1	-1.3	0.4
Run reversals in cocaine runway, females	3.3	3.2	6.4	-2.3	2.1	-1.7	-2.5	-1.4	0.3	2.0	0.4
Run reversals in cocaine runway, males	0.7	0.6	1.4	1.0	-1.2	0.7	0.9	0.9	-0.4	0.4	-0.3
Latency to leave start box in cocaine runway	0.6	0.7	1.9	-0.1	-0.9	-1.0	0.4	0.3	1.4	0.3	-1.0
Latency to leave start box in cocaine runway, F	0.2	0.2	1.2	0.1	-0.4	0.0	0.0	-0.3	0.0	-1.1	0.3
Latency to leave start box in cocaine runway, M	1.9	1.8	3.8	0.2	-1.4	-1.3	0.7	1.2	1.7	1.6	-1.9
Std. dev. time between licks in bursts	0.7	0.8	2.3	-0.3	1.3	0.6	-0.6	-0.9	-0.6	-1.5	0.8
Total sessions with >9 infusions	2.6	2.9	5.5	-2.4	1.2	-2.2	-2.0	-1.6	1.0	1.7	0.6
Short access day 1 total inactive lever presses	0.3	0.4	1.2	-0.4	-0.4	-0.6	0.2	-0.0	1.1	0.9	-0.5
Short access day 10 total inactive lever presses	0.8	0.8	1.6	0.6	-0.6	0.7	1.2	1.2	0.3	1.3	-1.0
Short access day 1 total infusions	1.9	2.1	4.2	-1.9	0.7	-2.0	-1.4	-1.1	1.6	1.5	-0.0
Short access day 10 total infusions	0.9	1.0	2.1	-1.5	0.6	-1.4	-1.1	-1.0	0.7	0.7	0.4
Short access total infusions	2.5	2.8	6.0	-2.3	1.3	-2.4	-1.6	-1.6	1.7	1.1	0.2
Short access day 1 locomotion	0.6	0.6	1.9	-0.9	-0.1	-1.1	-0.4	-0.3	1.0	1.4	-0.2
Short access day 10 total locomotion	1.1	1.2	2.3	-1.3	0.9	-1.5	-1.1	-1.4	0.2	-0.6	0.9
Short access total locomotion	2.5	2.6	7.0	-2.1	1.1	-2.6	-0.9	-1.3	2.1	0.8	-0.4
One hour access (0.3 mA shock)	0.6	0.7	1.8	-1.1	0.8	-1.2	-1.3	-0.8	0.3	-0.4	0.4
Compulsive drug intake	1.4	1.4	2.7	-0.8	1.1	-0.8	-1.2	-1.5	-0.5	-1.7	1.5
One hour access (shock baseline)	0.6	0.8	1.8	0.5	-0.8	0.2	0.6	1.2	0.8	0.9	-1.4
Social response proportion	0.4	0.5	1.0	-0.6	0.9	-0.6	-0.4	-1.0	0.2	-0.9	0.6
Social responses	0.6	0.7	2.6	0.9	-0.8	0.6	0.4	-0.1	-0.7	-1.6	0.9
Social time	0.6	0.8	2.4	1.1	-1.6	0.4	1.4	0.8	-0.0	-0.5	-0.2
Soleus weight	1.9	5.5	10.2	-2.8	2.0	-3.0	-1.8	-0.8	2.5	3.2	-1.7
Bone: stiffness	1.6	2.5	5.0	-2.1	1.1	-2.2	-1.4	-0.8	1.5	2.0	-0.6
Tibialis anterior weight	3.4	11.6	24.2	-4.9	3.5	-4.1	-4.0	-3.2	2.4	2.9	0.1
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	-0.2	0.4	0.0	-0.0	-0.3	0.1	0.1	-0.1
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.6	1.4	-1.2	1.1	1.2	0.6	-0.6	-1.6	0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.0	-0.1	0.3	-0.3	0.2	-0.6	0.3	0.0
Time to tail flick, test, after self-admin	1.2	1.2	3.3	1.0	-0.0	1.8	0.2	0.2	-1.6	-1.5	0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.5	0.1	0.1	0.1	-0.0	-0.5	-0.2	-1.2	0.7
Delta time to tail flick, test, before/after SA	0.5	0.4	1.5	0.1	0.6	0.6	-0.4	-0.5	-0.6	-1.2	0.7
Tibia length	0.2	0.6	1.6	-0.4	0.2	-0.9	0.4	0.2	1.3	0.9	-1.0
Ambulatory time before self-admin	1.4	1.5	3.3	0.6	-1.1	0.0	0.8	1.7	0.8	1.8	-1.8
Ambulatory time after self-admin	0.5	0.6	3.2	-0.5	-0.1	-0.4	-0.8	0.4	-0.2	1.8	-0.4
Bone: tissue strength	0.1	0.1	0.3	0.4	-0.5	0.1	0.1	0.5	-0.3	0.2	-0.2
Total heroin consumption	1.0	1.2	3.1	1.6	-1.7	0.1	1.3	0.9	-0.3	-1.3	0.0
Bone: trabecular number	0.4	0.6	1.3	-0.6	-0.3	-1.1	0.3	0.0	1.1	1.1	-0.7
Bone: trabecular spacing	1.3	1.6	4.3	0.4	0.6	1.2	-0.4	-0.8	-1.8	-2.1	1.7
Bone: trabecular thickness	3.4	4.0	10.3	-1.9	0.6	-2.9	-0.2	-0.3	3.2	2.4	-1.9
Bone: trabecular tissue density	0.6	0.8	2.4	0.3	-0.6	-0.5	0.7	1.1	0.8	1.0	-1.6
Water consumed over 24 hours	1.9	2.3	4.3	2.0	-1.8	1.9	0.7	1.5	-2.1	-0.2	0.3
Number of responses in last shaping day	0.2	0.3	0.6	-0.6	0.4	-0.8	-0.4	-0.2	0.6	0.5	-0.3