Hub : Genes

Xrn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Xrn1 0.03 0.02 5.5e-03 0 0.01 0 0 7.5e-02 6.6e-02 2.2e-01 1.7e-01
2 BLA alternative TSS NM_001305240.1 0.08 0.06 4.7e-03 0.02 0.02 0.01 0.02 1.9e-02 2.3e-02 6.3e-02 2.3e-02
3 Brain isoform ratio XM_039081173.1 0.05 0.03 5.3e-04 0.01 0.02 0 0.01 7.2e-02 3.3e-03 2.3e-01 1.9e-02
4 Liver mRNA stability Xrn1 0.03 0.02 8.6e-04 0 0 -0 -0 2.0e-01 1.1e-01 5.9e-01 8.4e-01
5 IL mRNA stability Xrn1 0.21 0.12 1.4e-03 0.04 0.01 -0 0.08 3.7e-02 2.0e-01 3.9e-01 6.3e-03
6 Brain intron excision ratio chr8_96548406_96550166 0.06 0.04 8.7e-05 0.05 0.04 0.03 0.04 3.3e-05 4.9e-05 3.5e-04 1.0e-04
7 Brain intron excision ratio chr8_96548412_96550166 0.06 0.04 1.3e-04 0.04 0.04 0.03 0.04 5.3e-05 9.1e-05 8.7e-04 1.2e-04
8 BLA isoform ratio XM_039081170.1 0.08 0.05 2.7e-03 0.05 0.03 0.01 0.03 1.6e-03 1.1e-02 1.4e-01 1.1e-02
9 Adipose intron excision ratio chr8_96548412_96550166 0.06 0.03 3.0e-07 0.06 0.06 0.05 0.06 3.8e-07 2.7e-07 1.2e-06 1.7e-07
10 Adipose intron excision ratio chr8_96548406_96550166 0.06 0.03 1.9e-07 0.06 0.06 0.06 0.06 2.7e-07 1.7e-07 6.9e-07 1.1e-07
11 Liver intron excision ratio chr8_96548406_96550166 0.02 0.02 8.8e-03 0.03 0 0.01 0.02 7.4e-04 2.3e-01 9.1e-03 2.3e-03
12 Liver intron excision ratio chr8_96548412_96550166 0.02 0.02 7.2e-03 0.03 0 0.01 0.02 5.6e-04 1.5e-01 7.4e-03 1.3e-03
13 Brain isoform ratio XM_039081170.1 0.12 0.06 6.4e-07 0.06 0.09 0.05 0.06 1.1e-06 2.6e-08 1.2e-05 1.7e-06
14 Adipose isoform ratio XM_039081170.1 0.07 0.04 3.0e-09 0.08 0.08 0.07 0.08 5.3e-09 2.7e-09 1.7e-08 5.3e-09
15 RMTg isoform ratio XM_008766573.3 0.13 0.08 3.7e-03 -0.01 0.03 -0 -0 5.2e-01 5.2e-02 4.2e-01 3.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.61.9-1.4-1.1-1.1-1.0-0.7-0.70.7-0.5-0.70.7-0.40.40.30.5-0.1
Area under the delay curve0.91.02.0-1.2-0.9-1.1-1.3-0.9-0.90.9-0.9-0.90.9-1.41.40.70.80.2
BMI with tail3.210.427.45.15.24.94.82.42.4-2.42.62.0-2.02.4-2.4-2.5-2.01.0
BMI without tail6.413.227.95.33.45.04.23.43.4-3.43.43.4-3.43.4-3.4-2.9-3.5-1.4
Body weight2.912.326.64.95.25.14.73.13.1-3.13.02.6-2.62.8-2.8-3.5-2.20.7
Weight adjusted by age1.21.43.51.61.51.81.90.90.9-0.91.40.8-0.80.6-0.6-1.4-0.90.2
Bone surface1.22.15.0-2.2-1.7-2.0-2.0-1.4-1.41.4-1.2-1.41.4-1.21.20.71.20.2
Bone volume0.61.12.4-1.6-1.2-1.4-1.4-1.1-1.11.1-0.8-1.11.1-0.80.80.50.80.0
Breakpoint value in progressive ratio session0.70.71.7-1.3-1.0-1.2-1.1-0.8-0.80.8-0.7-0.80.8-0.70.70.70.70.1
Number of licking bursts0.10.10.7-0.5-0.4-0.4-0.80.30.3-0.3-0.30.2-0.2-0.20.2-0.10.2-0.2
Context. condit. distance diff. score1.92.33.3-1.30.1-1.5-1.0-1.5-1.51.5-1.6-1.51.5-1.81.81.71.81.6
Locomotion velocity, session 10.91.03.51.91.81.51.50.60.6-0.60.60.6-0.60.6-0.6-0.1-0.60.4
Locomotion distance, session 11.31.78.02.52.82.02.10.50.5-0.50.50.5-0.50.5-0.50.1-0.41.1
Locomotion velocity, session 21.11.37.62.12.81.51.6-0.2-0.20.2-0.2-0.20.20.0-0.00.60.21.6
Locomotion distance, session 21.62.210.43.03.22.32.30.20.2-0.20.30.2-0.20.4-0.40.2-0.41.3
Locomotion velocity, session 31.61.93.40.20.6-0.4-1.1-1.5-1.51.5-1.6-1.41.4-1.91.91.81.11.2
Locomotion distance, session 31.01.11.9-0.60.1-0.8-0.9-1.2-1.21.2-1.1-1.21.2-1.41.41.01.00.9
Stereotopy head waving bouts, day 30.20.21.3-0.4-0.3-0.2-1.2-0.2-0.20.2-0.5-0.20.2-0.60.6-0.40.40.0
Stereotopy head waving duration, day 30.20.30.80.90.40.9-0.00.60.6-0.60.20.6-0.60.0-0.0-0.7-0.4-0.2
Locomotion velocity, session 70.91.04.62.12.01.61.70.30.3-0.30.20.3-0.30.1-0.10.4-0.40.8
Locomotion distance, session 70.70.91.91.20.71.11.40.90.9-0.91.00.8-0.81.0-1.0-0.5-0.9-0.3
Stereotopy head waving bouts, day 74.45.07.3-2.0-1.5-2.4-2.7-2.3-2.32.3-2.4-2.22.2-2.62.62.32.01.0
Stereotopy head waving duration, day 73.03.77.1-1.7-1.6-2.1-2.7-1.9-1.91.9-2.1-1.71.7-2.22.22.01.60.5
Locomotion velocity, session 81.01.23.01.41.70.50.7-0.7-0.70.7-0.9-0.60.6-1.31.31.70.61.5
Locomotion distance, session 80.91.33.70.81.70.10.4-1.0-1.01.0-1.1-1.01.0-1.11.11.61.11.9
Degree of sensitization distance2.52.53.91.40.61.51.91.81.8-1.81.61.7-1.72.0-2.0-1.2-1.5-0.9
Degree of sensitization stereotypy6.06.58.7-2.0-0.7-2.6-2.4-2.8-2.82.8-2.8-2.72.7-2.82.82.92.61.8
Conditioned locomotion0.70.81.60.8-0.80.60.80.90.9-0.90.91.0-1.00.9-0.9-0.0-1.2-1.3
Cocaine response after cond. corrected0.50.61.71.30.71.10.60.70.7-0.70.60.7-0.70.5-0.5-0.6-0.8-0.6
Cocaine response after cond. not corrected1.41.52.71.60.91.51.01.41.4-1.41.11.3-1.31.0-1.0-1.2-1.2-0.9
Cocaine response before conditioning0.60.71.20.70.30.80.61.11.1-1.10.81.0-1.00.8-0.8-0.9-0.8-0.6
Saline control response0.81.14.11.62.01.51.50.80.8-0.80.60.7-0.70.8-0.8-0.5-0.40.6
Bone: connectivity density0.61.02.3-1.5-1.5-1.4-1.2-0.9-0.90.9-0.7-0.80.8-0.70.70.80.6-0.2
Bone: cortical apparent density0.20.30.40.6-0.00.40.60.40.4-0.40.60.5-0.50.6-0.6-0.1-0.6-0.6
Bone: cortical area1.32.05.00.41.9-0.10.1-1.4-1.41.4-1.4-1.51.5-1.51.51.41.42.2
Bone: cortical porosity0.80.92.4-0.30.7-0.60.0-0.9-0.90.9-1.1-1.01.0-0.90.91.31.11.6
Bone: cortical porosity1.11.23.0-0.30.7-0.70.0-1.0-1.01.0-1.3-1.11.1-1.01.01.71.31.7
Bone: cortical thickness0.61.12.50.51.30.00.0-1.0-1.01.0-1.1-1.11.1-1.01.01.21.01.6
Bone: cortical thickness0.00.00.1-0.10.2-0.10.2-0.2-0.20.2-0.1-0.30.3-0.20.20.10.20.4
Bone: cortical tissue density0.20.20.40.6-0.00.40.60.40.4-0.40.50.5-0.50.6-0.6-0.1-0.6-0.5
Condit. Reinf. active minus inactive responses0.00.00.2-0.20.4-0.0-0.1-0.3-0.30.3-0.1-0.10.1-0.10.1-0.20.30.4
Condit. Reinf. active-inactive response ratio0.50.63.81.02.01.01.00.20.2-0.20.20.2-0.20.4-0.4-0.50.21.1
Condit. Reinf. active responses0.00.00.1-0.0-0.1-0.1-0.2-0.2-0.20.2-0.2-0.20.20.0-0.00.10.0-0.1
Condit. Reinf. inactive responses0.30.42.4-0.6-1.6-0.6-0.9-0.2-0.20.2-0.1-0.20.20.2-0.20.3-0.3-1.1
Incentive salience index mean0.30.31.1-0.00.9-0.0-0.0-0.7-0.70.7-0.5-0.50.5-0.20.20.30.71.0
Condit. Reinf. lever presses0.40.62.91.11.70.80.7-0.5-0.50.5-0.4-0.40.40.3-0.30.40.41.3
Condit. Reinf. active minus inactive responses0.10.20.3-0.1-0.30.1-0.20.50.5-0.50.30.5-0.50.3-0.3-0.6-0.4-0.5
Condit. Reinf. active-inactive response ratio1.71.82.61.50.81.61.01.51.5-1.51.31.5-1.51.4-1.4-1.6-1.3-0.9
Condit. Reinf. active responses0.30.41.3-1.0-1.1-0.9-1.1-0.4-0.40.4-0.6-0.30.3-0.60.60.40.4-0.2
Condit. Reinf. inactive responses1.31.72.8-1.6-1.4-1.7-1.5-1.2-1.21.2-1.2-1.11.1-1.41.41.31.00.3
Condit. Reinf. lever presses0.40.61.3-1.1-0.2-0.8-1.1-0.8-0.80.8-0.6-0.80.8-0.80.8-0.00.80.4
Condit. Reinf. lever reinforcers received0.30.51.3-1.1-0.9-1.0-1.1-0.4-0.40.4-0.7-0.40.4-0.70.70.40.50.0
Conditioned reinforcement - actives0.20.20.5-0.00.10.1-0.0-0.7-0.70.70.5-0.70.7-0.40.4-0.4-0.1-0.2
Conditioned reinforcement - inactives0.00.00.20.40.30.20.0-0.1-0.10.10.2-0.10.1-0.20.20.0-0.1-0.1
Conditioned locomotion0.10.10.80.40.90.20.3-0.2-0.20.2-0.1-0.20.2-0.00.00.20.20.4
Patch foraging indifference point 0 sec0.30.40.60.60.10.70.60.70.7-0.70.80.6-0.60.6-0.6-0.8-0.6-0.4
Patch foraging indifference point AUC0.10.20.50.4-0.20.20.70.20.2-0.20.20.2-0.20.7-0.70.5-0.4-0.1
Delay disc. indifference point, 0s delay1.51.63.2-1.5-1.6-1.5-1.8-1.0-1.01.0-1.1-0.90.9-1.81.80.90.7-0.2
Delay disc. indifference point, 16s delay0.50.51.3-0.40.0-0.4-0.6-0.7-0.70.7-0.7-0.70.7-1.11.10.40.70.7
Delay disc. indifference point, 2s delay0.30.41.4-0.10.5-0.1-0.5-0.5-0.50.5-0.5-0.60.6-1.21.20.20.50.5
Delay disc. indifference point, 24s delay0.20.20.5-0.7-0.4-0.6-0.2-0.3-0.30.3-0.3-0.30.3-0.50.50.40.40.2
Delay disc. indifference point, 4s delay0.70.72.2-0.7-1.5-0.9-1.4-0.6-0.60.6-0.6-0.40.4-1.11.10.60.1-0.7
Delay disc. indifference point, 8s delay0.90.92.5-1.6-0.8-1.3-1.2-0.9-0.90.9-0.9-1.01.0-0.80.80.51.00.5
Indifference point function ln k0.20.21.2-0.20.20.2-0.20.60.6-0.60.40.5-0.50.4-0.4-1.1-0.2-0.3
Indifference point function log k0.20.21.2-0.20.20.2-0.20.60.6-0.60.40.5-0.50.4-0.4-1.1-0.2-0.3
Patch foraging total patch changes 0 sec0.10.20.40.60.40.60.60.50.5-0.50.50.3-0.30.3-0.3-0.6-0.3-0.0
Patch foraging total patch changes 12 sec0.10.21.00.50.40.10.8-0.0-0.10.1-0.3-0.00.0-0.10.11.00.20.8
Patch foraging total patch changes 18 sec0.40.61.30.3-0.00.50.90.90.9-0.90.70.8-0.81.1-1.1-0.6-0.6-0.3
Patch foraging total patch changes 24 sec0.10.10.4-0.3-0.4-0.10.10.30.3-0.30.10.2-0.20.6-0.6-0.1-0.1-0.1
Patch foraging total patch changes 6 sec0.10.10.30.5-0.50.30.40.00.0-0.00.30.0-0.00.3-0.30.2-0.4-0.4
Patch foraging time to switch 0 sec0.40.72.9-1.2-1.7-1.3-1.1-0.3-0.30.3-0.5-0.10.1-0.70.70.80.2-0.7
Patch foraging water rate 0 sec0.71.22.81.51.31.71.30.90.9-0.91.20.7-0.70.9-0.9-1.4-0.9-0.1
Patch foraging water rate 12 sec0.20.32.00.81.40.90.40.20.2-0.20.30.1-0.10.2-0.2-0.8-0.10.5
Patch foraging water rate 18 sec1.11.55.92.02.41.91.70.70.7-0.71.00.6-0.60.8-0.8-1.2-0.60.5
Patch foraging water rate 24 sec0.20.30.80.70.70.90.50.20.2-0.20.60.1-0.10.4-0.4-0.9-0.5-0.1
Patch foraging water rate 6 sec0.20.32.10.81.50.90.30.20.2-0.20.20.0-0.00.0-0.0-0.80.00.6
Seeking ratio, delayed vs. immediate footshock0.91.02.5-1.0-1.0-1.2-0.6-1.1-1.11.1-1.1-1.01.0-0.80.81.60.90.6
Distance traveled before self-admin0.60.63.51.41.91.21.30.10.1-0.10.50.00.00.1-0.1-0.3-0.30.6
Distance traveled after self-admin0.30.30.60.20.10.50.80.50.5-0.50.80.4-0.40.7-0.7-0.8-0.5-0.3
Extensor digitorum longus weight0.62.214.52.53.81.91.6-0.2-0.20.2-0.3-0.50.5-0.30.30.30.42.1
Bone: elastic displacement0.60.73.41.11.81.11.50.10.1-0.10.3-0.10.10.6-0.6-0.2-0.01.0
Bone: elastic work0.30.42.50.81.60.71.0-0.1-0.10.10.0-0.20.30.4-0.4-0.00.10.9
Bone: endosteal estimation0.20.41.40.61.20.30.2-0.6-0.60.6-0.4-0.60.6-0.70.70.40.40.8
Bone: endosteal perimeter0.81.64.30.52.10.20.4-1.2-1.21.2-1.0-1.41.4-1.31.30.91.22.0
Epididymis fat weight0.71.74.62.11.82.01.91.21.2-1.21.21.1-1.10.6-0.6-0.9-1.1-0.1
Delta time in closed arm before/after self-admin4.03.87.7-1.4-0.3-1.9-1.6-2.0-2.02.0-2.6-1.91.9-2.12.12.82.01.7
Delta time in open arm before/after self-admin0.70.71.10.6-0.50.60.60.90.9-0.90.91.0-1.00.9-0.9-0.5-1.0-1.0
Diff in mean of infusions in LGA sessions0.80.91.9-1.4-0.7-1.2-1.4-0.9-0.90.9-0.9-0.90.9-0.90.90.41.00.4
Delay discount exponential model param0.60.61.30.90.90.91.00.60.6-0.60.70.6-0.61.1-1.1-0.5-0.5-0.0
Extinction: sum of active levers before priming0.10.10.60.10.20.20.80.30.3-0.30.20.3-0.30.3-0.30.1-0.10.3
Active lever presses in extinction session 60.20.20.40.20.30.20.70.60.6-0.60.20.5-0.50.6-0.6-0.0-0.20.1
Bone: final force0.20.30.40.00.5-0.1-0.4-0.6-0.60.6-0.6-0.60.6-0.70.70.40.40.5
Bone: final moment0.10.10.40.20.60.2-0.2-0.4-0.40.4-0.4-0.40.4-0.40.40.10.30.4
Food consumed during 24 hour testing period0.20.20.8-0.9-0.9-0.6-0.90.20.2-0.2-0.10.2-0.20.2-0.2-0.30.1-0.5
Glucose0.10.20.50.50.60.20.1-0.3-0.30.3-0.4-0.20.2-0.30.30.70.30.6
Heart weight0.30.41.60.11.30.60.90.30.3-0.30.70.1-0.10.5-0.5-1.30.00.5
Delay discount hyperbolic model param0.60.61.30.90.70.91.00.70.7-0.70.70.7-0.71.2-1.2-0.5-0.6-0.1
Intermittent access intake day 1-15 change0.10.10.50.00.20.30.2-0.2-0.20.20.6-0.30.3-0.20.2-0.7-0.2-0.0
Intermittent access intake escalation0.10.10.20.10.20.20.3-0.4-0.40.40.4-0.50.5-0.40.4-0.4-0.00.2
Intermittent access intake escalation 20.90.91.5-1.1-0.7-0.9-0.9-1.1-1.11.1-0.3-1.21.2-1.21.20.10.70.2
Intermitt. access day 1 inactive lever presses0.20.20.91.00.90.60.90.10.1-0.10.20.1-0.10.2-0.20.5-0.10.4
Intermitt. access day 15 inactive lever presses1.51.62.2-0.60.4-0.9-0.8-1.5-1.51.5-1.3-1.51.5-1.51.51.41.41.3
Intermitt. access escalation Index0.20.20.80.3-0.30.40.00.30.3-0.30.80.4-0.40.3-0.3-0.6-0.7-0.9
Intermittent access day 1 total infusions0.10.11.00.61.00.40.3-0.1-0.10.10.2-0.10.1-0.10.1-0.1-0.10.1
Intermittent access day 15 total infusions0.20.21.00.81.00.60.3-0.4-0.40.40.4-0.40.4-0.40.4-0.2-0.10.1
Intermittent access terminal intake (last 3 days)0.30.31.10.21.00.2-0.1-0.7-0.70.70.1-0.80.8-0.60.6-0.30.30.5
Intermittent access total infusions0.20.20.90.31.00.10.0-0.5-0.50.5-0.1-0.50.5-0.50.50.20.20.4
Intermittent access day 1 locomotion0.30.31.01.01.00.80.70.40.4-0.40.50.4-0.40.3-0.3-0.2-0.4-0.1
Intermittent access day 15 total locomotion0.30.30.70.30.7-0.0-0.1-0.6-0.60.6-0.3-0.60.6-0.80.80.50.40.5
Intermittent access total locomotion0.20.20.80.60.90.40.5-0.3-0.30.30.3-0.30.3-0.50.50.1-0.10.1
Intermittent access standard deviation2.52.64.0-0.70.1-1.0-1.3-2.0-2.02.0-1.6-2.02.0-1.91.91.61.51.4
Left kidney weight1.64.415.33.53.93.13.01.51.5-1.51.21.2-1.21.6-1.6-1.1-0.91.1
Right kidney weight1.43.914.03.33.73.03.01.31.3-1.31.41.0-1.01.4-1.4-1.3-0.91.0
Cocaine induced anxiety2.52.93.7-1.9-0.5-1.9-1.6-1.9-1.91.9-1.6-1.91.9-1.91.91.51.71.1
Post-drug Anxiety2.12.33.2-1.50.0-1.6-1.4-1.7-1.71.7-1.8-1.61.6-1.41.41.61.71.3
Baseline Anxiety0.20.20.40.30.60.40.50.50.5-0.50.00.4-0.40.6-0.6-0.1-0.10.2
Tail length2.57.610.42.40.22.71.93.23.2-3.22.93.2-3.22.7-2.7-3.0-2.9-2.5
Length with tail0.41.53.90.70.61.20.91.51.5-1.51.31.3-1.31.0-1.0-2.0-0.9-0.4
Length without tail0.51.14.3-1.11.1-0.5-0.1-0.7-0.70.7-0.8-1.21.2-0.80.8-0.41.62.1
Times rat made contact with spout1.51.82.8-1.10.5-1.1-1.1-1.4-1.41.4-1.5-1.51.5-1.21.21.01.71.6
Lifetime Intake0.10.10.90.30.90.10.1-0.2-0.20.2-0.0-0.30.3-0.30.30.00.20.2
Liver weight, left0.10.20.70.80.40.60.20.30.3-0.30.30.4-0.40.3-0.3-0.3-0.4-0.2
Liver weight, right0.50.94.72.02.21.41.10.20.2-0.20.00.1-0.10.1-0.10.4-0.10.8
Locomotor activity3.45.48.02.11.12.62.42.42.4-2.42.72.3-2.32.5-2.5-2.8-2.3-1.4
Locomotor testing distance1.32.13.21.40.81.71.61.41.4-1.41.71.4-1.41.7-1.7-1.8-1.5-0.9
Locomotor testing rearing0.60.92.91.71.41.61.30.40.4-0.41.00.4-0.40.7-0.7-0.6-0.9-0.2
Locomotion in novel chamber0.60.71.8-0.9-1.3-1.0-1.3-0.9-0.90.9-0.5-0.80.7-0.80.80.50.3-0.5
Locomotion in novel chamber post-restriction0.40.51.5-0.3-0.70.0-0.20.70.7-0.70.80.7-0.70.3-0.3-1.1-0.7-1.2
Fecal boli incidents, locomotor time 10.30.31.61.11.30.80.60.10.1-0.10.00.1-0.10.0-0.00.0-0.20.4
Change in fecal boli incidents, locomotor task1.31.21.91.10.41.31.41.21.2-1.21.21.1-1.11.2-1.2-1.1-1.0-0.5
Time >=10cm from walls, locomotor time 10.20.20.60.00.5-0.10.2-0.4-0.40.4-0.4-0.40.4-0.30.30.50.50.8
Bouts of movement, locomotor time 10.00.00.1-0.1-0.0-0.0-0.4-0.1-0.10.1-0.1-0.10.1-0.10.1-0.20.1-0.1
Total resting periods, locomotor time 10.00.00.10.00.1-0.0-0.4-0.2-0.20.2-0.2-0.20.2-0.20.2-0.10.20.2
Rest time, locomotor task time 12.93.16.5-0.61.4-0.8-0.7-1.9-1.91.9-1.9-2.12.1-1.81.81.62.12.5
Distance moved, locomotor task time 11.31.42.61.0-0.60.90.81.31.3-1.31.31.4-1.41.0-1.0-0.8-1.5-1.6
Vertical activity count, locomotor time 10.20.20.8-0.6-0.9-0.6-0.6-0.0-0.00.0-0.10.0-0.0-0.20.20.3-0.1-0.6
Time >=10cm from walls, locomotor time 22.82.94.0-1.7-0.5-1.8-1.6-1.8-1.81.8-1.8-1.81.8-2.02.01.61.81.4
Bouts of movement, locomotor time 20.20.20.80.50.90.20.3-0.3-0.30.3-0.4-0.30.3-0.30.30.60.30.7
Total resting periods, locomotor time 20.20.20.80.30.90.10.2-0.4-0.40.4-0.4-0.40.4-0.40.40.50.40.8
Rest time, locomotor task time 20.00.10.2-0.20.4-0.10.0-0.2-0.20.2-0.2-0.30.30.2-0.20.10.30.4
Distance moved, locomotor task time 20.91.02.1-0.8-1.2-1.0-1.3-1.0-1.01.0-1.0-0.80.8-1.51.51.10.6-0.0
Vertical activity count, locomotor time 21.41.62.3-1.4-0.8-1.5-1.4-1.2-1.21.2-1.3-1.21.2-1.51.51.31.10.4
Light reinforcement 10.20.30.7-0.3-0.2-0.3-0.7-0.8-0.80.8-0.4-0.80.8-0.60.60.20.40.2
Light reinforcement 20.60.81.1-0.80.0-0.7-1.0-1.0-1.01.0-0.9-1.01.0-0.90.90.41.00.8
Bone: marrow area0.20.41.70.71.30.40.3-0.6-0.60.6-0.3-0.60.6-0.60.60.40.30.9
Bone: maximum diameter1.22.29.01.53.00.81.1-1.1-1.11.1-1.0-1.31.3-1.21.21.31.12.5
Bone: maximum force0.40.70.9-0.20.8-0.3-0.4-0.9-0.90.9-0.8-1.01.0-0.90.90.70.80.9
Bone: maximum moment0.30.41.00.11.0-0.1-0.2-0.7-0.70.7-0.6-0.80.8-0.70.70.50.70.9
Mean time between licks in bursts0.71.02.2-1.00.4-1.0-0.6-0.8-0.80.8-1.2-1.01.0-0.80.80.91.41.5
Mean num. licks in bursts0.70.81.9-0.11.0-0.10.3-1.2-1.21.2-0.6-1.21.2-0.60.60.60.91.4
Cd content in liver3.33.64.4-2.0-0.7-2.1-2.0-2.0-2.02.0-2.1-2.12.1-1.81.81.72.11.5
Co content in liver0.70.81.4-0.30.7-0.6-0.2-1.0-1.01.0-1.0-1.01.0-0.70.71.21.01.2
Cu content in liver1.62.04.8-2.2-1.4-1.9-2.2-1.3-1.31.3-1.3-1.31.3-1.01.00.61.30.3
Fe content in liver0.70.93.2-1.8-0.9-1.3-1.5-0.7-0.70.7-0.7-0.90.9-0.40.4-0.10.90.2
K content in liver0.70.73.51.90.61.31.00.60.6-0.60.50.7-0.70.1-0.10.3-1.0-0.5
Mg content in liver0.20.21.11.00.40.60.40.00.0-0.00.00.2-0.2-0.10.10.5-0.4-0.1
Mn content in liver0.80.92.31.01.50.40.5-0.8-0.80.8-0.8-0.70.7-1.11.11.30.51.2
Na content in liver0.40.41.11.1-0.10.80.60.60.6-0.60.60.8-0.80.2-0.2-0.0-1.0-0.9
Rb content in liver0.20.20.30.4-0.00.50.30.50.5-0.50.50.5-0.50.6-0.6-0.6-0.6-0.5
Se content in liver0.20.31.9-0.6-1.4-0.5-0.60.10.1-0.10.10.2-0.20.1-0.1-0.1-0.3-0.9
Sr content in liver0.10.10.5-0.2-0.7-0.3-0.6-0.3-0.30.3-0.2-0.20.2-0.20.20.30.1-0.3
Zn content in liver0.00.00.10.20.00.20.10.20.2-0.20.20.2-0.20.3-0.3-0.0-0.3-0.3
Bone: minimum diameter0.81.52.1-0.80.5-0.9-0.9-1.3-1.31.3-1.4-1.41.4-1.51.51.01.41.4
Time in familiar zone, hab. session 11.61.55.6-1.0-2.4-0.4-0.70.90.9-0.91.01.0-1.01.2-1.2-1.2-1.1-2.1
Time in novel zone, hab. session 10.80.84.91.02.20.71.0-0.3-0.30.3-0.4-0.50.5-0.60.60.40.61.6
Total zone transitions, hab. session 10.91.36.12.52.31.71.8-0.2-0.20.20.0-0.10.10.2-0.20.8-0.31.1
Total locomotion distance, hab. session 11.52.17.82.82.02.32.40.80.8-0.81.20.8-0.81.1-1.1-0.4-1.30.1
Locomotion velocity, hab. session 11.41.98.62.92.12.32.40.50.5-0.50.90.6-0.60.8-0.80.1-1.10.4
Time in familiar zone, hab. session 20.20.20.6-0.5-0.6-0.30.00.20.2-0.20.40.1-0.10.8-0.8-0.3-0.2-0.5
Time in novel zone, hab. session 20.40.42.30.81.50.60.60.00.0-0.0-0.2-0.00.0-0.50.50.10.31.0
Total zone transitions, hab. session 21.01.25.62.42.31.81.70.10.1-0.10.20.2-0.20.1-0.10.4-0.31.0
Total locomotion distance, hab. session 21.82.47.22.71.82.32.41.21.2-1.21.31.2-1.21.2-1.2-0.7-1.4-0.2
Locomotion velocity, hab. session 21.62.27.22.71.82.32.31.01.0-1.01.21.1-1.11.1-1.1-0.5-1.4-0.1
Novel to familiar place preference ratio0.20.20.50.00.00.20.60.70.7-0.70.40.6-0.60.5-0.5-0.4-0.2-0.0
Novelty place preference0.30.30.60.10.30.40.70.80.8-0.80.50.6-0.60.7-0.7-0.7-0.20.1
Time in novel zone, NPP test0.50.50.90.30.70.60.90.90.9-0.90.60.7-0.70.8-0.8-0.9-0.30.2
Total zone transitions, NPP test2.53.514.63.43.82.93.00.80.8-0.80.90.7-0.70.9-0.9-0.5-0.71.4
Total locomotion distance, NPP test3.04.113.63.73.03.23.11.41.4-1.41.51.4-1.41.6-1.6-0.9-1.50.4
Locomotion velocity, NPP test2.33.311.53.42.52.92.71.21.2-1.21.31.3-1.31.4-1.4-0.6-1.40.2
Intraocular pressure0.30.41.51.01.21.00.70.30.3-0.30.20.3-0.30.6-0.6-0.4-0.30.4
Delta distance traveled before/after self-admin0.40.52.6-0.9-1.6-0.6-0.30.50.5-0.50.40.5-0.50.7-0.7-0.4-0.4-0.9
Delta ambulatory time before/after self-admin0.60.62.0-0.4-1.4-0.10.10.70.7-0.70.70.8-0.81.0-1.0-0.7-0.7-1.1
Parametrial fat weight0.10.20.9-0.4-0.6-0.4-1.0-0.4-0.40.4-0.2-0.50.4-0.60.60.10.1-0.3
Pavlov. Cond. lever latency0.40.51.6-0.2-1.1-0.0-0.30.70.7-0.70.60.8-0.80.1-0.1-0.6-0.7-1.3
Pavlov. Cond. magazine entry latency1.51.94.50.01.7-0.3-0.1-1.6-1.61.6-1.3-1.71.7-1.21.21.21.52.1
Pavlov. Cond. change in total contacts1.31.42.6-0.50.7-0.7-0.5-1.5-1.51.5-1.1-1.61.6-1.11.11.11.31.4
Pavlov. Cond. index score0.81.13.10.11.5-0.10.2-1.1-1.11.1-0.9-1.31.3-0.60.60.91.11.8
Pavlov. Cond. latency score0.60.82.70.31.60.20.5-0.8-0.80.8-0.7-1.01.0-0.30.30.60.91.6
Pavlov. Cond. lever contacts0.40.51.90.11.20.00.5-0.6-0.60.6-0.6-0.80.8-0.30.30.70.81.4
Pavlov. Cond. magazine entry number1.21.52.90.5-1.10.60.31.41.4-1.41.11.5-1.50.9-0.9-1.0-1.4-1.7
Pavlov. Cond. intertrial magazine entries0.70.94.8-1.7-2.2-1.3-1.5-0.0-0.00.0-0.2-0.10.1-0.30.3-0.10.1-1.1
Pavlov. Cond. lever-magazine prob. diff.1.11.43.3-0.21.3-0.4-0.0-1.3-1.31.3-1.1-1.51.5-0.90.91.11.31.8
Pavlov. Cond. response bias1.72.13.3-0.80.7-1.0-0.8-1.7-1.71.7-1.5-1.81.8-1.31.31.31.61.7
Pavlov. Cond. lever latency0.10.10.5-0.2-0.7-0.4-0.6-0.2-0.20.2-0.2-0.20.2-0.10.10.30.0-0.4
Pavlov. Cond. magazine entry latency0.40.52.0-0.11.2-0.00.2-0.6-0.60.6-0.7-0.70.7-0.20.20.30.91.4
Pavlov. Cond. change in total contacts0.70.92.61.31.61.31.30.90.9-0.90.60.8-0.80.7-0.7-0.8-0.50.4
Pavlov. Cond. index score0.10.10.5-0.10.70.10.2-0.0-0.00.0-0.2-0.20.20.0-0.0-0.20.40.7
Pavlov. Cond. latency score0.10.10.7-0.10.80.10.3-0.1-0.10.1-0.2-0.20.2-0.00.0-0.20.40.8
Pavlov. Cond. lever contacts0.10.10.6-0.10.80.00.2-0.2-0.20.2-0.2-0.30.3-0.20.2-0.10.40.8
Pavlov. Cond. magazine entry number0.80.92.10.5-0.70.60.51.01.0-1.01.21.1-1.10.8-0.8-0.9-1.2-1.4
Pavlov. Cond. intertrial magazine entries0.91.28.5-1.6-2.9-1.4-1.30.10.1-0.10.10.3-0.3-0.30.30.1-0.3-1.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.8-0.10.90.10.3-0.1-0.10.1-0.3-0.30.3-0.10.1-0.10.50.9
Pavlov. Cond. response bias0.30.41.3-0.30.8-0.3-0.1-0.6-0.60.6-0.7-0.70.7-0.50.50.50.81.1
Time in closed arm before self-admin5.96.79.82.00.52.52.02.82.8-2.83.02.8-2.82.8-2.8-3.1-2.6-2.2
Time in closed arm after self-admin0.40.40.90.91.00.80.80.60.6-0.60.60.6-0.60.6-0.6-0.5-0.5-0.1
Time in open arm before self-admin1.41.52.3-1.2-0.7-1.4-1.3-1.3-1.31.3-1.5-1.21.2-1.31.31.41.20.9
Time in open arm after self-admin0.60.62.7-1.2-1.6-1.2-0.9-0.5-0.50.5-0.8-0.40.4-0.50.51.10.4-0.2
Bone: periosteal estimation0.71.53.60.71.90.20.2-1.2-1.21.2-1.1-1.31.3-1.41.41.11.11.8
Bone: periosteal perimeter1.62.76.50.42.3-0.20.2-1.6-1.61.6-1.5-1.81.8-1.81.81.71.72.5
Bone: post-yield work1.01.32.4-1.4-0.4-1.3-1.5-1.1-1.11.1-1.2-1.21.2-1.21.20.81.20.7
Progressive ratio test 1 active lever presses0.30.31.10.80.50.80.90.10.1-0.11.00.2-0.2-0.00.0-0.6-0.7-0.5
Progressive ratio test 1 breakpoint0.40.41.20.90.90.91.10.10.1-0.11.00.1-0.1-0.00.0-0.6-0.7-0.3
Progressive ratio test 1 inactive lever presses0.30.30.80.60.30.60.90.60.6-0.60.90.6-0.60.2-0.2-0.5-0.6-0.4
Progressive ratio test 2 active lever presses0.30.40.80.10.80.20.2-0.8-0.80.80.1-0.90.9-0.60.60.00.30.5
Progressive ratio test 2 breakpoint0.20.20.40.10.60.20.1-0.6-0.60.60.2-0.60.6-0.40.4-0.20.10.2
Progressive ratio test 2 inactive lever presses0.20.20.4-0.3-0.3-0.3-0.4-0.7-0.70.70.1-0.60.6-0.50.50.00.0-0.2
Incentive Sensitization - Responses2.93.04.8-0.70.8-1.0-1.2-2.2-2.22.2-1.7-2.22.2-1.81.81.61.61.6
Incentive Sensitization - Breakpoint3.03.15.2-0.70.8-0.9-1.2-2.3-2.32.3-1.5-2.32.3-1.91.91.41.51.6
Sum of active levers in priming session hrs 5-60.30.31.80.31.30.20.7-0.1-0.10.1-0.4-0.20.20.0-0.00.50.51.1
Progressive ratio0.40.42.11.11.50.91.00.10.1-0.1-0.00.1-0.10.4-0.40.00.00.9
Food seeking constrained by brief footshock1.82.23.3-0.70.6-1.1-1.0-1.7-1.71.7-1.8-1.71.7-1.51.51.81.61.5
Seeking ratio, punishment vs. effort1.21.52.3-1.2-0.7-1.4-1.5-1.3-1.31.3-1.2-1.31.3-1.31.31.21.10.4
Retroperitoneal fat weight1.44.78.83.02.02.92.32.22.2-2.22.12.0-2.02.0-2.0-2.0-2.0-0.8
Reaction time number correct0.50.71.01.00.31.00.80.80.8-0.81.00.8-0.80.9-0.9-0.8-1.0-0.8
Reaction time mean minus median0.10.10.80.40.90.20.40.20.2-0.2-0.10.1-0.1-0.00.00.10.20.5
Reaction time mean minus median AUC0.20.21.70.81.30.50.50.10.1-0.1-0.20.1-0.1-0.10.10.20.20.6
Reaction time num false alarms0.30.52.2-0.9-1.5-0.5-0.30.60.6-0.60.30.6-0.60.5-0.5-0.6-0.3-0.8
Reaction time num false alarms AUC0.40.53.4-1.2-1.9-0.9-0.70.30.3-0.30.10.3-0.30.1-0.1-0.3-0.1-0.8
Reaction time trials correct on left0.50.71.01.00.31.00.80.80.8-0.81.00.8-0.80.9-0.9-0.8-1.0-0.8
Reaction time trials on left0.50.71.11.00.31.00.80.80.8-0.81.00.8-0.80.9-0.9-0.8-1.0-0.8
Reaction time mean1.01.42.4-1.1-0.2-1.2-1.2-1.0-1.01.0-1.5-1.01.0-1.41.41.21.41.2
Reaction time mean AUC0.81.11.8-1.1-0.5-1.2-1.3-0.9-0.90.9-1.3-0.90.9-1.31.31.11.20.8
Median of all reaction times1.62.23.4-1.5-0.8-1.7-1.7-1.3-1.31.3-1.9-1.31.3-1.81.81.51.61.1
Reaction time omissions0.10.10.40.2-0.10.10.30.60.6-0.60.20.6-0.60.3-0.3-0.0-0.3-0.3
Reaction time false alarm rate0.30.52.8-1.4-1.7-1.1-0.9-0.0-0.00.0-0.3-0.00.0-0.30.3-0.00.3-0.4
Reaction time premature initiation rate0.60.91.4-0.8-0.7-0.9-1.2-1.1-1.11.1-0.9-1.01.0-0.80.80.90.80.3
Reaction time premature initiations0.10.20.4-0.1-0.3-0.3-0.5-0.6-0.60.6-0.3-0.50.5-0.30.30.50.2-0.0
Std. dev. reaction times0.10.10.3-0.30.1-0.4-0.30.00.0-0.0-0.6-0.00.0-0.30.30.40.60.5
Reaction time trials completed0.50.71.11.00.31.00.80.80.8-0.81.00.8-0.80.9-0.9-0.8-1.0-0.8
Reaction time trials AUC0.40.60.80.70.10.80.60.80.8-0.80.90.8-0.80.8-0.8-0.7-0.8-0.7
Run reversals in cocaine runway, females2.22.23.01.40.11.51.41.61.6-1.61.51.7-1.71.4-1.4-1.3-1.7-1.4
Run reversals in cocaine runway, males3.53.45.1-1.30.7-1.4-1.4-2.1-2.12.1-1.9-2.32.3-1.81.81.42.22.1
Latency to leave start box in cocaine runway0.91.03.7-1.6-1.9-1.5-1.6-0.7-0.70.7-0.6-0.50.5-0.50.50.80.4-0.6
Latency to leave start box in cocaine runway, F0.50.62.1-0.3-1.4-0.1-0.10.60.6-0.60.80.7-0.70.5-0.5-0.6-0.9-1.4
Latency to leave start box in cocaine runway, M3.43.36.0-2.1-1.4-2.3-2.5-1.8-1.81.8-2.1-1.71.7-1.41.42.01.70.6
Std. dev. time between licks in bursts0.50.61.6-0.4-0.1-0.7-0.4-0.8-0.80.8-0.8-0.80.8-0.90.91.30.60.5
Total sessions with >9 infusions0.30.30.60.40.60.60.50.60.6-0.60.70.5-0.50.6-0.6-0.8-0.5-0.3
Short access day 1 total inactive lever presses0.10.10.60.70.00.10.4-0.1-0.10.10.20.0-0.00.2-0.20.8-0.4-0.4
Short access day 10 total inactive lever presses1.11.21.80.20.8-0.30.1-1.3-1.31.3-0.8-1.31.3-1.31.31.30.91.2
Short access day 1 total infusions0.10.20.50.70.50.40.40.30.3-0.30.50.4-0.40.1-0.1-0.1-0.4-0.4
Short access day 10 total infusions0.30.31.50.81.20.80.80.10.1-0.10.60.1-0.10.0-0.0-0.5-0.30.1
Short access total infusions0.10.20.60.50.80.40.50.40.4-0.40.30.4-0.40.3-0.3-0.1-0.3-0.2
Short access day 1 locomotion1.82.03.21.70.21.51.61.51.5-1.51.51.6-1.60.9-0.9-0.6-1.8-1.4
Short access day 10 total locomotion0.50.51.20.61.10.20.6-0.7-0.70.7-0.1-0.70.7-1.01.00.70.40.8
Short access total locomotion1.21.22.71.51.21.41.71.01.0-1.01.31.0-1.00.9-0.9-0.7-1.1-0.4
One hour access (0.3 mA shock)0.10.10.5-0.3-0.5-0.1-0.30.20.2-0.20.30.2-0.2-0.10.1-0.4-0.3-0.7
Compulsive drug intake2.32.34.40.3-1.80.50.41.81.8-1.81.31.9-1.91.4-1.4-0.9-1.7-2.1
One hour access (shock baseline)1.41.62.6-1.20.3-1.1-1.2-1.6-1.61.6-1.1-1.61.6-1.31.30.71.31.0
Social response proportion0.40.51.4-1.2-0.7-1.0-0.7-0.6-0.60.6-0.3-0.60.6-0.90.90.10.60.1
Social responses1.51.93.8-1.1-0.4-1.2-1.3-1.6-1.61.6-1.2-1.51.5-1.91.91.11.20.8
Social time1.11.42.3-1.5-0.3-1.4-1.4-1.2-1.21.2-1.2-1.31.3-1.21.20.81.30.8
Soleus weight0.41.25.22.32.22.01.30.50.5-0.50.50.4-0.40.4-0.4-0.5-0.60.5
Bone: stiffness1.42.23.1-1.3-0.1-1.5-1.6-1.5-1.51.5-1.6-1.61.6-1.81.81.41.61.1
Tibialis anterior weight0.82.87.02.22.62.42.11.51.5-1.51.41.3-1.31.3-1.3-1.8-1.10.2
Time to tail flick, vehicle, before self-admin0.00.00.20.4-0.10.3-0.0-0.2-0.20.20.2-0.10.1-0.20.20.0-0.3-0.3
Time to tail flick, vehicle, after self-admin0.91.01.71.21.01.21.31.11.1-1.10.71.0-1.01.0-1.0-0.6-0.7-0.1
Time to tail flick, test, before self-admin0.40.41.6-0.7-0.6-0.8-1.3-0.6-0.60.6-0.7-0.50.5-0.70.70.40.6-0.0
Time to tail flick, test, after self-admin0.50.51.10.90.51.10.50.70.7-0.70.70.6-0.60.5-0.5-1.0-0.6-0.2
Delta time to tail flick, vehicle, before/after SA0.70.71.20.71.00.71.11.01.0-1.00.50.9-0.91.0-1.0-0.4-0.40.1
Delta time to tail flick, test, before/after SA2.01.82.61.40.41.61.31.41.4-1.41.51.4-1.41.4-1.4-1.6-1.4-0.8
Tibia length0.92.55.21.61.11.91.11.71.7-1.71.61.6-1.61.4-1.4-2.3-1.3-0.8
Ambulatory time before self-admin0.50.53.21.31.81.11.1-0.0-0.00.00.5-0.10.10.0-0.0-0.3-0.10.7
Ambulatory time after self-admin0.50.51.30.50.10.71.00.60.6-0.61.10.5-0.50.9-0.9-1.0-0.8-0.5
Bone: tissue strength0.40.41.00.50.20.60.00.60.6-0.60.60.6-0.60.7-0.7-1.0-0.6-0.6
Total heroin consumption1.11.32.9-1.60.3-1.3-1.3-0.8-0.80.8-1.7-1.01.0-0.70.70.91.71.5
Bone: trabecular number1.01.63.7-1.9-1.6-1.8-1.6-1.2-1.21.2-1.1-1.21.2-0.90.91.01.00.2
Bone: trabecular spacing0.81.01.81.40.31.21.00.90.9-0.91.11.0-1.01.1-1.1-0.8-1.2-0.8
Bone: trabecular thickness1.51.82.41.40.71.61.51.41.4-1.41.41.4-1.41.3-1.3-1.3-1.5-1.0
Bone: trabecular tissue density1.01.43.31.71.71.61.81.11.1-1.11.01.1-1.10.7-0.7-0.7-0.90.0
Water consumed over 24 hours0.10.10.8-0.7-0.4-0.5-0.9-0.1-0.10.1-0.4-0.10.1-0.20.2-0.00.40.0
Number of responses in last shaping day1.01.12.61.40.51.41.30.80.8-0.81.60.8-0.80.8-0.8-1.2-1.2-0.8