Hub : Genes

Xrn1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS XM_039081173.1 0.05 0.04 6.8e-03 0.03 0.02 0.03 0.02 2.2e-03 2.8e-03 1.2e-03 6.1e-03
2 IL isoform ratio XM_039081173.1 0.17 0.1 9.7e-03 0.03 0.06 0.02 0.02 7.8e-02 1.8e-02 1.2e-01 1.3e-01
3 Brain isoform ratio XM_039081173.1 0.04 0.03 2.4e-03 -0 0.02 0 0 1.0e+00 4.3e-03 1.1e-01 2.0e-01
4 Adipose gene expression Xrn1 0.03 0.02 2.8e-03 0.01 0.02 0.01 0 5.8e-02 6.5e-03 1.3e-02 8.1e-02
5 PL intron excision ratio chr8_105455905_105458954 0.04 0.03 4.5e-03 0.01 0.01 0 0.01 9.6e-03 7.4e-03 1.1e-01 3.8e-02
6 Adipose isoform ratio XM_063265209.1 0.06 0.03 3.3e-08 0.08 0.07 0.06 0.07 8.9e-09 4.0e-08 4.7e-07 1.6e-08
7 Adipose isoform ratio XM_217233.11 0.02 0.01 6.9e-03 0.01 0 0 0 1.3e-02 9.0e-02 1.3e-01 1.3e-01
8 Brain isoform ratio XM_063265209.1 0.08 0.05 7.9e-05 0.06 0.04 0.04 0.04 4.9e-06 6.3e-05 1.2e-04 7.8e-05
9 Brain intron excision ratio chr8_105427993_105429753 0.06 0.04 8.2e-05 0.06 0.04 0.04 0.05 5.7e-06 8.1e-05 7.8e-05 2.6e-05
10 Brain intron excision ratio chr8_105427999_105429753 0.06 0.04 1.1e-04 0.06 0.04 0.04 0.05 7.7e-06 1.1e-04 5.8e-05 3.2e-05
11 Liver intron excision ratio chr8_105427993_105429753 0.03 0.02 3.3e-03 0.03 0.01 0 0.01 7.4e-04 2.5e-02 7.4e-02 7.2e-03
12 Liver intron excision ratio chr8_105427999_105429753 0.03 0.02 3.8e-03 0.03 0.01 0 0.01 7.3e-04 2.5e-02 7.7e-02 7.2e-03
13 pVTA isoform ratio XM_063265209.1 0.07 0.05 4.3e-03 0 0.04 0.02 0.01 2.0e-01 8.0e-04 5.0e-03 3.0e-02
14 Adipose intron excision ratio chr8_105427999_105429753 0.05 0.03 3.7e-07 0.06 0.06 0.06 0.06 3.3e-07 2.6e-07 7.9e-07 3.0e-07
15 Adipose intron excision ratio chr8_105427993_105429753 0.06 0.03 2.3e-07 0.06 0.06 0.06 0.06 2.3e-07 1.5e-07 5.8e-07 2.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.61.9-1.4-1.2-1.0-1.00.7-0.20.20.70.7-0.70.7-0.70.4-0.10.1
Area under the delay curve1.11.32.2-0.4-0.8-1.2-1.21.00.8-0.81.51.5-1.51.5-1.50.8-0.80.8
BMI with tail2.910.135.65.06.04.94.9-2.6-2.42.4-1.8-1.81.8-1.81.8-2.01.2-1.2
BMI without tail3.510.829.05.44.24.84.6-3.4-2.92.9-2.3-2.32.3-2.32.3-2.82.1-2.1
Body weight2.08.625.34.75.04.04.4-2.2-2.62.6-2.0-2.02.0-2.02.0-1.61.4-1.4
Weight adjusted by age0.91.43.01.41.51.61.7-1.0-1.41.4-0.8-0.80.8-0.80.8-1.11.0-1.0
Bone surface1.12.04.0-1.7-1.9-2.0-1.91.40.5-0.51.51.5-1.51.5-1.51.3-0.80.8
Bone volume0.61.02.3-1.5-1.5-1.4-1.30.9-0.00.01.01.0-1.01.0-1.00.7-0.40.3
Breakpoint value in progressive ratio session0.20.31.6-1.3-0.3-0.5-0.40.40.3-0.30.50.5-0.50.5-0.50.4-0.20.2
Number of licking bursts0.10.20.50.5-0.7-0.5-0.50.10.3-0.3-0.6-0.60.6-0.60.60.4-0.10.1
Context. condit. distance diff. score2.32.73.6-1.40.2-1.5-1.41.91.7-1.71.81.8-1.81.8-1.81.6-1.71.7
Locomotion velocity, session 10.70.82.71.51.61.51.4-1.0-0.50.50.10.1-0.10.1-0.1-0.90.3-0.3
Locomotion distance, session 11.11.37.11.72.72.01.9-1.0-0.60.6-0.2-0.20.2-0.20.2-0.70.1-0.1
Locomotion velocity, session 21.01.17.22.12.71.51.3-0.40.1-0.10.30.3-0.30.3-0.3-0.4-0.50.5
Locomotion distance, session 21.52.29.73.03.12.42.1-1.2-0.70.7-0.1-0.10.1-0.10.1-0.9-0.00.0
Locomotion velocity, session 32.42.74.91.90.1-0.3-0.90.61.9-1.92.22.2-2.22.2-2.20.9-1.31.3
Locomotion distance, session 31.71.83.70.1-0.1-0.7-0.91.01.4-1.41.91.9-1.91.9-1.90.9-0.90.9
Stereotopy head waving bouts, day 30.40.54.82.2-0.6-0.4-0.50.20.6-0.60.00.0-0.00.0-0.00.8-0.40.4
Stereotopy head waving duration, day 30.70.96.52.50.20.80.6-0.8-0.00.0-1.0-1.01.0-1.01.0-0.20.2-0.3
Locomotion velocity, session 71.11.24.92.22.21.81.5-0.9-0.30.30.30.3-0.30.3-0.3-1.00.1-0.1
Locomotion distance, session 70.70.81.61.21.11.31.2-0.9-1.21.2-0.3-0.30.3-0.30.3-1.30.8-0.8
Stereotopy head waving bouts, day 75.96.610.4-1.8-1.8-2.7-2.92.33.2-3.22.62.6-2.62.6-2.62.6-2.42.3
Stereotopy head waving duration, day 73.23.86.9-1.4-2.1-2.1-2.41.52.6-2.61.81.8-1.81.8-1.81.8-1.61.6
Locomotion velocity, session 80.70.82.00.91.40.60.30.00.9-0.91.01.0-1.01.0-1.00.1-1.01.0
Locomotion distance, session 80.81.12.70.81.60.20.10.61.0-1.01.21.2-1.21.2-1.20.6-1.21.2
Degree of sensitization distance3.03.14.30.71.01.71.7-1.5-2.02.0-2.1-2.12.1-2.12.1-1.81.5-1.5
Degree of sensitization stereotypy6.46.910.9-2.5-1.0-2.5-2.62.53.3-3.32.62.6-2.62.6-2.62.6-2.62.6
Conditioned locomotion0.60.72.1-0.8-0.40.70.6-1.1-0.90.9-0.5-0.50.5-0.50.5-1.41.0-1.0
Cocaine response after cond. corrected0.50.72.91.70.11.00.8-1.3-0.60.6-0.6-0.60.6-0.60.6-0.70.7-0.7
Cocaine response after cond. not corrected1.31.64.22.00.31.41.3-1.7-1.11.1-1.2-1.21.2-1.21.2-1.01.1-1.1
Cocaine response before conditioning0.60.71.00.70.20.80.8-0.9-0.70.7-1.0-1.01.0-1.01.0-0.70.8-0.8
Saline control response0.40.63.11.31.81.11.1-0.4-0.20.2-0.4-0.40.4-0.40.4-0.2-0.00.1
Bone: connectivity density0.60.92.6-1.6-1.5-1.3-1.30.70.2-0.21.01.0-1.01.0-1.00.4-0.30.3
Bone: cortical apparent density0.40.51.0-0.40.20.50.5-0.6-0.50.5-1.0-1.01.0-1.01.0-0.50.4-0.4
Bone: cortical area0.81.23.00.21.7-0.00.01.00.8-0.81.21.2-1.21.2-1.21.2-1.51.5
Bone: cortical porosity0.80.91.5-0.81.0-0.4-0.41.20.9-0.91.01.0-1.01.0-1.00.7-1.11.1
Bone: cortical porosity1.31.42.3-1.21.1-0.6-0.61.51.3-1.31.21.2-1.21.2-1.20.9-1.41.4
Bone: cortical thickness0.30.41.70.61.30.20.10.50.5-0.50.60.6-0.60.6-0.60.6-0.91.0
Bone: cortical thickness0.00.00.2-0.40.3-0.00.10.3-0.30.3-0.1-0.10.1-0.10.1-0.0-0.00.0
Bone: cortical tissue density0.30.51.0-0.30.20.50.5-0.6-0.40.4-1.0-1.01.0-1.01.0-0.50.4-0.4
Condit. Reinf. active minus inactive responses0.10.11.01.00.3-0.10.00.3-0.10.10.00.0-0.00.0-0.00.4-0.20.2
Condit. Reinf. active-inactive response ratio0.80.84.01.72.00.91.1-0.1-0.20.2-0.8-0.80.8-0.80.80.1-0.20.2
Condit. Reinf. active responses0.10.10.70.8-0.2-0.0-0.20.0-0.10.10.20.2-0.20.2-0.2-0.0-0.00.0
Condit. Reinf. inactive responses0.30.43.2-0.4-1.8-0.5-0.8-0.2-0.20.20.40.4-0.40.4-0.4-0.40.4-0.4
Incentive salience index mean0.30.31.81.30.9-0.0-0.00.60.3-0.30.30.3-0.30.3-0.30.6-0.70.7
Condit. Reinf. lever presses0.40.53.01.71.70.70.60.20.2-0.2-0.0-0.00.0-0.00.00.3-0.70.7
Condit. Reinf. active minus inactive responses0.10.20.50.7-0.40.10.0-0.2-0.40.4-0.5-0.50.5-0.50.5-0.10.4-0.4
Condit. Reinf. active-inactive response ratio2.12.46.02.40.41.51.3-1.5-1.31.3-1.8-1.81.8-1.81.8-1.01.3-1.3
Condit. Reinf. active responses0.30.41.2-0.6-1.1-0.9-1.00.60.3-0.30.70.7-0.70.7-0.70.6-0.20.2
Condit. Reinf. inactive responses1.52.03.9-2.0-1.2-1.5-1.51.30.9-0.91.71.7-1.71.7-1.70.9-0.90.9
Condit. Reinf. lever presses0.50.61.10.5-0.5-0.9-0.80.90.6-0.61.01.0-1.01.0-1.01.0-0.60.6
Condit. Reinf. lever reinforcers received0.40.51.0-0.6-0.9-1.0-1.00.80.4-0.40.80.8-0.80.8-0.80.7-0.40.4
Conditioned reinforcement - actives0.20.30.60.3-0.8-0.5-0.50.00.1-0.10.80.8-0.80.8-0.80.3-0.20.2
Conditioned reinforcement - inactives0.10.10.3-0.10.1-0.0-0.10.00.3-0.30.50.5-0.50.5-0.50.3-0.40.4
Conditioned locomotion0.10.10.3-0.5-0.5-0.4-0.40.00.3-0.30.30.3-0.30.3-0.30.2-0.30.3
Patch foraging indifference point 0 sec0.20.30.70.50.20.60.7-0.7-0.80.8-0.3-0.30.3-0.30.3-0.60.5-0.5
Patch foraging indifference point AUC0.30.51.0-0.50.20.50.4-0.3-0.30.3-1.0-1.01.0-1.01.0-0.80.4-0.4
Delay disc. indifference point, 0s delay1.92.14.0-0.8-1.5-1.4-1.51.00.9-0.92.02.0-2.02.0-2.00.8-0.60.6
Delay disc. indifference point, 16s delay0.50.61.20.90.2-0.3-0.30.60.5-0.51.11.1-1.11.1-1.10.6-0.60.6
Delay disc. indifference point, 2s delay0.60.71.51.20.2-0.2-0.20.30.3-0.31.21.2-1.21.2-1.20.5-0.60.6
Delay disc. indifference point, 24s delay0.30.31.2-1.1-0.2-0.6-0.50.60.4-0.40.70.7-0.70.7-0.70.2-0.30.3
Delay disc. indifference point, 4s delay1.01.03.0-0.1-1.7-0.8-1.10.10.3-0.31.41.4-1.41.4-1.40.2-0.20.1
Delay disc. indifference point, 8s delay0.70.81.7-1.1-0.6-1.3-1.11.30.8-0.80.70.7-0.70.7-0.71.0-0.80.8
Indifference point function ln k0.10.11.21.10.20.20.4-0.2-0.30.30.10.1-0.10.1-0.10.20.3-0.3
Indifference point function log k0.10.11.21.10.20.20.4-0.2-0.30.30.10.1-0.10.1-0.10.20.3-0.3
Patch foraging total patch changes 0 sec0.10.20.40.60.50.60.7-0.5-0.70.7-0.1-0.10.1-0.10.1-0.40.3-0.3
Patch foraging total patch changes 12 sec0.10.20.9-0.90.60.20.10.30.2-0.2-0.5-0.50.5-0.50.5-0.3-0.20.2
Patch foraging total patch changes 18 sec0.71.12.2-0.20.30.60.8-0.5-1.01.0-1.5-1.51.5-1.51.5-0.90.8-0.8
Patch foraging total patch changes 24 sec0.20.30.6-0.6-0.2-0.10.00.0-0.50.5-0.7-0.70.7-0.70.7-0.20.4-0.4
Patch foraging total patch changes 6 sec0.10.10.7-0.0-0.40.30.1-0.5-0.40.4-0.1-0.10.1-0.10.1-0.80.5-0.5
Patch foraging time to switch 0 sec0.40.94.1-2.0-1.8-1.2-1.30.40.5-0.50.60.6-0.60.6-0.60.3-0.20.2
Patch foraging water rate 0 sec0.71.45.02.21.41.61.6-1.1-1.21.2-0.7-0.70.7-0.70.7-0.90.8-0.8
Patch foraging water rate 12 sec0.30.55.22.31.10.80.8-0.3-0.30.30.00.0-0.00.0-0.0-0.00.1-0.1
Patch foraging water rate 18 sec1.01.67.42.72.31.81.9-1.1-0.90.9-0.5-0.50.5-0.50.5-0.50.4-0.4
Patch foraging water rate 24 sec0.40.54.22.00.60.80.8-0.6-0.70.7-0.1-0.10.1-0.10.1-0.50.5-0.5
Patch foraging water rate 6 sec0.40.65.42.31.10.70.8-0.3-0.20.2-0.3-0.30.3-0.30.30.3-0.10.1
Seeking ratio, delayed vs. immediate footshock1.11.35.1-2.3-0.3-1.1-1.21.40.9-0.91.01.0-1.01.0-1.00.7-1.11.1
Distance traveled before self-admin0.20.21.40.21.20.70.7-0.3-0.20.20.30.3-0.30.3-0.3-0.2-0.10.1
Distance traveled after self-admin0.10.10.4-0.40.20.20.4-0.2-0.60.60.30.3-0.30.3-0.3-0.30.4-0.4
Extensor digitorum longus weight0.41.710.22.83.21.71.6-0.40.3-0.30.40.4-0.40.4-0.40.3-0.80.8
Bone: elastic displacement0.70.84.00.72.01.01.2-0.1-0.50.5-1.0-1.01.0-1.01.0-0.30.1-0.1
Bone: elastic work0.40.52.40.71.50.80.8-0.0-0.40.4-0.8-0.80.8-0.80.8-0.1-0.10.1
Bone: endosteal estimation0.10.30.50.40.70.20.10.20.1-0.10.70.7-0.70.7-0.70.4-0.50.5
Bone: endosteal perimeter0.71.42.70.11.6-0.00.10.80.7-0.71.61.6-1.61.6-1.61.1-1.31.3
Epididymis fat weight0.62.05.11.41.92.32.1-1.6-1.41.4-0.9-0.90.9-0.90.9-1.51.2-1.2
Delta time in closed arm before/after self-admin2.82.64.8-1.4-0.5-1.6-1.81.82.2-2.21.31.3-1.31.3-1.31.5-1.81.8
Delta time in open arm before/after self-admin0.20.20.8-0.3-0.60.30.1-0.6-0.40.4-0.3-0.30.3-0.30.3-0.90.6-0.6
Diff in mean of infusions in LGA sessions1.82.22.8-1.2-0.7-1.6-1.51.51.4-1.41.71.7-1.71.7-1.71.6-1.31.3
Delay discount exponential model param0.80.91.70.30.70.91.0-0.8-0.50.5-1.3-1.31.3-1.31.3-0.60.6-0.6
Extinction: sum of active levers before priming0.30.31.0-0.91.00.40.70.1-0.40.4-0.5-0.50.5-0.50.5-0.30.3-0.3
Active lever presses in extinction session 60.30.31.5-1.20.50.10.30.1-0.20.2-0.7-0.70.7-0.70.7-0.10.2-0.1
Bone: final force0.10.10.80.90.2-0.1-0.20.40.1-0.10.30.3-0.30.3-0.30.4-0.40.4
Bone: final moment0.10.11.71.30.40.20.10.1-0.10.10.20.2-0.20.2-0.20.2-0.20.2
Food consumed during 24 hour testing period0.20.21.3-0.5-1.1-0.8-0.70.20.1-0.1-0.4-0.40.4-0.40.40.40.0-0.0
Glucose0.30.51.71.31.01.21.0-0.8-0.70.7-0.3-0.30.3-0.30.3-0.70.4-0.4
Heart weight0.40.62.21.01.50.81.2-0.4-1.21.20.10.1-0.10.1-0.1-0.10.3-0.2
Delay discount hyperbolic model param0.70.71.40.10.80.90.9-0.6-0.40.4-1.2-1.21.2-1.21.2-0.50.5-0.5
Intermittent access intake day 1-15 change0.20.30.6-0.7-0.4-0.5-0.40.40.1-0.10.80.8-0.80.8-0.80.3-0.20.2
Intermittent access intake escalation0.10.20.4-0.6-0.4-0.4-0.30.2-0.10.10.60.6-0.60.6-0.60.1-0.00.0
Intermittent access intake escalation 21.41.62.6-1.5-1.3-1.6-1.41.20.7-0.71.41.4-1.41.4-1.41.0-0.70.7
Intermitt. access day 1 inactive lever presses0.00.10.3-0.40.60.40.4-0.30.0-0.0-0.3-0.30.3-0.30.3-0.1-0.10.1
Intermitt. access day 15 inactive lever presses1.53.03.6-1.7-0.8-1.8-1.81.61.7-1.71.91.9-1.91.9-1.91.7-1.71.7
Intermitt. access escalation Index0.40.51.10.1-1.00.30.2-1.1-1.01.0-0.4-0.40.4-0.40.4-0.81.0-1.0
Intermittent access day 1 total infusions0.10.20.60.80.10.1-0.0-0.30.3-0.30.60.6-0.60.6-0.60.3-0.40.4
Intermittent access day 15 total infusions0.30.41.31.1-0.10.1-0.0-0.40.1-0.10.90.9-0.90.9-0.90.1-0.20.2
Intermittent access terminal intake (last 3 days)0.40.51.10.8-0.1-0.3-0.30.10.4-0.41.11.1-1.11.1-1.10.7-0.60.6
Intermittent access total infusions0.40.51.00.90.2-0.1-0.20.00.6-0.61.01.0-1.01.0-1.00.6-0.70.7
Intermittent access day 1 locomotion0.10.20.80.90.70.70.6-0.7-0.10.10.20.2-0.20.2-0.2-0.2-0.00.1
Intermittent access day 15 total locomotion0.71.22.40.40.5-0.3-0.40.51.0-1.01.61.6-1.61.6-1.60.8-1.11.1
Intermittent access total locomotion0.40.51.20.30.60.20.2-0.30.1-0.11.11.1-1.11.1-1.10.3-0.50.5
Intermittent access standard deviation1.53.14.7-0.2-0.2-1.3-1.51.51.9-1.92.22.2-2.22.2-2.21.8-1.81.8
Left kidney weight1.56.919.03.24.43.43.9-2.1-2.62.6-2.2-2.22.2-2.22.2-1.61.2-1.2
Right kidney weight1.35.818.03.44.23.43.6-2.1-2.22.2-1.8-1.81.8-1.81.8-1.40.9-0.9
Cocaine induced anxiety0.50.71.9-1.4-0.7-0.9-0.60.50.1-0.11.11.1-1.11.1-1.10.6-0.30.3
Post-drug Anxiety0.91.01.7-1.1-0.7-1.0-0.90.60.6-0.61.31.3-1.31.3-1.30.9-0.70.7
Baseline Anxiety0.20.20.80.40.5-0.0-0.20.40.9-0.90.30.3-0.30.3-0.30.5-0.70.7
Tail length0.93.44.61.90.01.51.7-1.9-2.22.2-1.9-1.91.9-1.91.9-1.72.0-2.1
Length with tail0.10.41.21.10.80.50.9-0.2-0.80.8-0.6-0.60.6-0.60.6-0.00.5-0.5
Length without tail0.10.41.70.81.3-0.20.40.80.1-0.10.20.2-0.20.2-0.21.2-0.60.6
Times rat made contact with spout1.11.33.30.40.5-1.2-1.01.61.5-1.50.20.2-0.20.2-0.21.8-1.71.7
Lifetime Intake0.30.40.80.90.1-0.1-0.2-0.00.5-0.50.80.8-0.80.8-0.80.6-0.50.5
Liver weight, left0.30.41.81.21.30.91.0-0.5-0.50.50.30.3-0.30.3-0.30.0-0.10.1
Liver weight, right0.61.02.21.51.41.51.5-1.3-0.80.8-0.6-0.60.6-0.60.6-0.70.5-0.5
Locomotor activity3.65.67.12.21.32.42.6-2.4-2.72.7-2.5-2.52.5-2.52.5-2.22.3-2.2
Locomotor testing distance1.22.22.61.50.61.41.5-1.5-1.61.6-1.6-1.61.6-1.61.6-1.41.5-1.5
Locomotor testing rearing0.61.13.41.81.01.51.3-1.3-1.01.0-0.8-0.80.8-0.80.8-1.00.8-0.8
Locomotion in novel chamber0.30.43.7-0.4-1.9-0.9-1.0-0.10.0-0.00.10.1-0.10.1-0.10.10.2-0.2
Locomotion in novel chamber post-restriction0.20.31.0-0.0-1.0-0.00.1-0.7-0.90.9-0.2-0.20.2-0.20.2-0.50.8-0.8
Fecal boli incidents, locomotor time 10.20.32.11.50.70.80.5-0.5-0.30.3-0.4-0.40.4-0.40.4-0.30.0-0.0
Change in fecal boli incidents, locomotor task1.61.62.40.61.01.41.6-1.2-1.41.4-1.3-1.31.3-1.31.3-1.31.2-1.2
Time >=10cm from walls, locomotor time 10.20.20.6-0.40.8-0.00.00.40.4-0.40.40.4-0.40.4-0.40.4-0.50.5
Bouts of movement, locomotor time 10.00.00.30.5-0.2-0.1-0.1-0.1-0.00.00.00.0-0.00.0-0.00.2-0.10.1
Total resting periods, locomotor time 10.10.10.70.8-0.0-0.0-0.1-0.00.0-0.00.10.1-0.10.1-0.10.4-0.30.3
Rest time, locomotor task time 11.41.83.40.61.5-0.6-0.51.51.3-1.31.31.3-1.31.3-1.31.7-1.81.8
Distance moved, locomotor task time 10.81.22.60.2-0.80.90.7-1.5-1.21.2-0.9-0.90.9-0.90.9-1.61.5-1.5
Vertical activity count, locomotor time 10.10.31.7-1.2-1.3-0.6-0.7-0.00.3-0.30.40.4-0.40.4-0.4-0.00.1-0.1
Time >=10cm from walls, locomotor time 21.92.93.3-1.3-0.2-1.7-1.61.81.8-1.81.81.8-1.81.8-1.81.8-1.71.7
Bouts of movement, locomotor time 20.10.20.80.20.90.40.30.10.2-0.20.50.5-0.50.5-0.50.1-0.30.4
Total resting periods, locomotor time 20.10.21.00.21.00.20.20.30.2-0.20.60.6-0.60.6-0.60.3-0.50.5
Rest time, locomotor task time 20.00.10.2-0.20.4-0.2-0.10.3-0.10.10.00.0-0.00.0-0.00.4-0.40.4
Distance moved, locomotor task time 20.80.91.7-0.2-1.3-0.9-1.30.51.0-1.01.11.1-1.11.1-1.10.3-0.50.5
Vertical activity count, locomotor time 21.21.72.3-1.5-1.1-1.4-1.51.21.4-1.41.31.3-1.31.3-1.31.0-1.00.9
Light reinforcement 10.20.41.61.3-0.3-0.3-0.40.20.3-0.30.80.8-0.80.8-0.80.4-0.40.4
Light reinforcement 20.40.61.31.00.0-0.7-0.70.90.9-0.90.40.4-0.40.4-0.41.1-1.01.0
Bone: marrow area0.10.30.70.40.80.20.20.10.1-0.10.80.8-0.80.8-0.80.4-0.50.5
Bone: maximum diameter0.71.26.30.72.50.70.70.40.6-0.61.11.1-1.11.1-1.10.8-1.41.4
Bone: maximum force0.30.50.80.10.4-0.4-0.40.70.4-0.40.80.8-0.80.8-0.80.8-0.90.9
Bone: maximum moment0.20.30.40.50.7-0.1-0.10.50.1-0.10.70.7-0.70.7-0.70.6-0.70.7
Mean time between licks in bursts0.30.71.8-0.60.6-0.8-0.61.31.0-1.00.10.1-0.10.1-0.11.2-1.21.2
Mean num. licks in bursts0.30.41.8-0.01.3-0.10.00.90.7-0.70.30.3-0.30.3-0.30.8-1.01.0
Cd content in liver1.61.83.0-1.6-1.0-1.7-1.61.51.2-1.21.31.3-1.31.3-1.31.3-1.11.1
Co content in liver0.50.50.7-0.40.7-0.4-0.30.80.8-0.80.80.8-0.80.8-0.80.7-0.80.8
Cu content in liver1.11.32.6-0.5-1.3-1.6-1.61.31.1-1.10.90.9-0.90.9-0.91.4-1.01.0
Fe content in liver0.30.41.20.2-0.6-1.0-0.90.80.6-0.6-0.2-0.20.2-0.20.21.1-0.60.6
K content in liver0.80.72.51.60.61.51.0-1.3-0.40.40.10.1-0.10.1-0.1-1.30.7-0.7
Mg content in liver0.20.20.40.40.00.3-0.1-0.20.5-0.50.60.6-0.60.6-0.6-0.3-0.10.1
Mn content in liver0.91.02.41.01.60.40.10.51.4-1.41.01.0-1.01.0-1.00.5-1.11.1
Na content in liver0.20.20.40.2-0.40.4-0.1-0.50.2-0.20.50.5-0.50.5-0.5-0.60.2-0.2
Rb content in liver0.10.10.20.10.20.0-0.10.20.5-0.50.20.2-0.20.2-0.20.3-0.30.3
Se content in liver0.20.31.7-0.3-1.3-0.6-0.80.1-0.20.2-0.4-0.40.4-0.40.40.00.2-0.2
Sr content in liver0.60.60.9-0.2-0.7-0.7-0.90.50.4-0.41.01.0-1.01.0-1.00.6-0.70.7
Zn content in liver0.30.30.9-0.2-1.00.2-0.0-0.7-0.60.60.10.1-0.10.1-0.1-0.90.8-0.9
Bone: minimum diameter0.71.32.4-0.80.2-1.1-1.01.51.0-1.01.11.1-1.11.1-1.11.5-1.41.4
Time in familiar zone, hab. session 11.61.55.0-1.3-2.2-0.5-0.4-0.6-0.70.7-1.4-1.41.4-1.41.4-0.71.3-1.3
Time in novel zone, hab. session 10.90.95.01.42.20.70.80.20.1-0.11.01.0-1.01.0-1.00.4-0.70.8
Total zone transitions, hab. session 10.71.05.41.62.31.91.4-0.7-0.30.3-0.1-0.10.1-0.10.1-0.8-0.10.1
Total locomotion distance, hab. session 11.52.25.81.92.12.42.1-1.6-1.51.5-0.7-0.70.7-0.70.7-1.81.0-0.9
Locomotion velocity, hab. session 11.31.85.81.62.22.42.0-1.4-1.21.2-0.5-0.50.5-0.50.5-1.70.7-0.7
Time in familiar zone, hab. session 20.40.52.3-1.5-0.6-0.4-0.20.1-0.10.1-0.9-0.90.9-0.90.9-0.10.3-0.3
Time in novel zone, hab. session 20.50.52.51.61.60.70.7-0.1-0.10.10.60.6-0.60.6-0.60.2-0.40.5
Total zone transitions, hab. session 21.01.35.52.32.41.91.6-0.9-0.50.5-0.0-0.00.0-0.00.0-0.80.0-0.0
Total locomotion distance, hab. session 22.02.66.02.11.92.42.2-1.8-1.91.9-0.7-0.70.7-0.70.7-1.91.2-1.2
Locomotion velocity, hab. session 21.82.45.82.11.92.42.1-1.8-1.81.8-0.7-0.70.7-0.70.7-1.91.1-1.1
Novel to familiar place preference ratio0.20.21.0-1.00.50.30.50.0-0.60.6-0.5-0.50.5-0.50.5-0.30.3-0.3
Novelty place preference0.30.40.6-0.60.80.40.7-0.0-0.70.7-0.7-0.70.7-0.70.7-0.30.3-0.3
Time in novel zone, NPP test0.50.51.3-0.41.20.60.9-0.1-0.80.8-0.8-0.80.8-0.80.8-0.20.3-0.3
Total zone transitions, NPP test2.53.715.83.54.03.02.9-1.5-1.21.2-0.7-0.70.7-0.70.7-1.20.3-0.3
Total locomotion distance, NPP test3.34.412.43.53.13.33.0-2.2-1.91.9-1.1-1.11.1-1.11.1-2.01.1-1.1
Locomotion velocity, NPP test2.63.710.83.32.63.02.6-2.1-1.81.8-1.0-1.01.0-1.01.0-2.01.1-1.1
Intraocular pressure0.30.42.61.61.00.90.7-0.4-0.10.10.30.3-0.30.3-0.3-0.30.1-0.1
Delta distance traveled before/after self-admin0.40.40.7-0.9-0.8-0.10.1-0.2-0.80.8-0.5-0.50.5-0.50.5-0.60.9-0.9
Delta ambulatory time before/after self-admin1.21.42.4-0.1-0.70.70.8-1.1-1.51.5-1.2-1.21.2-1.21.2-1.31.5-1.5
Parametrial fat weight0.20.43.31.80.60.90.7-0.6-0.40.40.20.2-0.20.2-0.2-0.50.4-0.4
Pavlov. Cond. lever latency0.20.32.2-0.8-1.5-0.2-0.3-0.6-0.00.00.30.3-0.30.3-0.3-0.30.6-0.6
Pavlov. Cond. magazine entry latency0.91.23.50.91.9-0.2-0.21.30.9-0.90.90.9-0.90.9-0.91.3-1.51.5
Pavlov. Cond. change in total contacts0.90.91.50.10.7-0.7-0.61.10.8-0.81.11.1-1.11.1-1.11.1-1.21.2
Pavlov. Cond. index score0.50.62.90.61.7-0.10.01.00.5-0.50.20.2-0.20.2-0.20.9-1.11.2
Pavlov. Cond. latency score0.40.53.50.91.90.20.30.80.3-0.3-0.1-0.10.1-0.10.10.6-0.90.9
Pavlov. Cond. lever contacts0.30.42.80.51.70.20.30.70.2-0.2-0.1-0.10.1-0.10.10.4-0.80.8
Pavlov. Cond. magazine entry number0.60.81.8-0.2-1.20.60.5-1.3-0.80.8-0.5-0.50.5-0.50.5-1.31.3-1.3
Pavlov. Cond. intertrial magazine entries0.60.85.2-1.1-2.3-1.5-1.40.50.3-0.30.30.3-0.30.3-0.30.40.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.60.72.30.41.5-0.4-0.31.20.7-0.70.50.5-0.50.5-0.51.0-1.31.4
Pavlov. Cond. response bias0.81.02.30.21.0-0.8-0.71.41.0-1.00.80.8-0.80.8-0.81.4-1.51.5
Pavlov. Cond. lever latency0.10.10.6-0.8-0.7-0.2-0.3-0.20.1-0.10.10.1-0.10.1-0.1-0.0-0.00.0
Pavlov. Cond. magazine entry latency0.40.52.31.11.50.00.20.80.5-0.50.10.1-0.10.1-0.10.8-0.90.9
Pavlov. Cond. change in total contacts0.71.13.41.91.71.21.2-0.4-0.40.4-1.0-1.01.0-1.01.0-0.40.3-0.3
Pavlov. Cond. index score0.20.21.01.01.00.00.20.60.2-0.2-0.1-0.10.1-0.10.10.5-0.40.4
Pavlov. Cond. latency score0.20.21.21.01.10.10.30.50.2-0.2-0.0-0.00.0-0.00.00.4-0.40.4
Pavlov. Cond. lever contacts0.10.21.10.91.00.10.30.50.1-0.10.00.0-0.00.0-0.00.3-0.30.3
Pavlov. Cond. magazine entry number0.60.81.3-0.8-0.80.50.5-1.1-1.11.1-0.6-0.60.6-0.60.6-1.11.2-1.2
Pavlov. Cond. intertrial magazine entries0.91.38.2-2.6-2.9-1.3-1.40.1-0.00.00.30.3-0.30.3-0.3-0.20.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.21.11.01.10.00.20.60.3-0.30.00.0-0.00.0-0.00.5-0.40.5
Pavlov. Cond. response bias0.30.31.30.91.1-0.10.00.80.6-0.60.30.3-0.30.3-0.30.7-0.70.7
Time in closed arm before self-admin3.13.95.61.80.52.02.1-2.4-2.32.3-1.9-1.91.9-1.91.9-1.92.0-2.0
Time in closed arm after self-admin0.20.30.50.70.60.70.7-0.7-0.40.4-0.4-0.40.4-0.40.4-0.40.3-0.3
Time in open arm before self-admin0.70.71.5-0.5-0.4-1.0-1.11.21.1-1.10.60.6-0.60.6-0.60.9-0.90.9
Time in open arm after self-admin0.80.93.4-1.8-1.4-1.3-1.41.01.0-1.00.50.5-0.50.5-0.50.3-0.50.5
Bone: periosteal estimation0.51.12.00.31.40.1-0.00.70.6-0.61.31.3-1.31.3-1.31.0-1.31.3
Bone: periosteal perimeter1.32.33.5-0.41.8-0.4-0.31.31.2-1.21.81.8-1.81.8-1.81.6-1.91.9
Bone: post-yield work1.42.12.9-0.8-0.8-1.6-1.51.41.1-1.11.71.7-1.71.7-1.71.6-1.31.3
Progressive ratio test 1 active lever presses0.20.30.80.60.10.60.7-0.9-0.90.90.00.0-0.00.0-0.0-0.60.6-0.6
Progressive ratio test 1 breakpoint0.30.30.80.50.20.70.7-0.9-0.90.90.00.0-0.00.0-0.0-0.60.6-0.6
Progressive ratio test 1 inactive lever presses0.30.40.9-0.8-0.70.30.3-0.9-0.80.8-0.2-0.20.2-0.20.2-0.70.8-0.8
Progressive ratio test 2 active lever presses0.30.30.70.60.2-0.1-0.10.20.2-0.20.80.8-0.80.8-0.80.4-0.40.4
Progressive ratio test 2 breakpoint0.20.30.60.50.1-0.1-0.20.20.2-0.20.80.8-0.80.8-0.80.4-0.30.3
Progressive ratio test 2 inactive lever presses0.30.50.9-0.3-0.7-0.6-0.70.30.4-0.41.01.0-1.01.0-1.00.6-0.40.4
Incentive Sensitization - Responses2.23.14.40.30.2-1.2-1.41.82.0-2.02.12.1-2.12.1-2.11.9-1.81.8
Incentive Sensitization - Breakpoint2.43.24.70.30.2-1.2-1.41.81.9-1.92.22.2-2.22.2-2.21.9-1.81.8
Sum of active levers in priming session hrs 5-60.50.51.0-0.90.7-0.4-0.40.91.0-1.00.40.4-0.40.4-0.40.9-0.90.9
Progressive ratio0.30.42.81.01.70.40.40.60.5-0.50.10.1-0.10.1-0.10.4-0.80.8
Food seeking constrained by brief footshock1.41.72.4-0.40.3-0.9-1.01.21.5-1.51.41.4-1.41.4-1.41.3-1.61.6
Seeking ratio, punishment vs. effort0.91.31.9-1.0-1.0-1.2-1.30.81.0-1.01.41.4-1.41.4-1.41.0-0.90.9
Retroperitoneal fat weight0.73.09.13.02.42.72.4-1.7-1.41.4-1.0-1.01.0-1.01.0-1.71.1-1.1
Reaction time number correct0.30.51.30.20.10.80.9-1.1-1.01.0-0.5-0.50.5-0.50.5-0.90.9-0.8
Reaction time mean minus median0.10.10.3-0.20.60.10.3-0.20.1-0.1-0.5-0.50.5-0.50.50.2-0.30.3
Reaction time mean minus median AUC0.10.20.60.40.80.40.4-0.30.3-0.3-0.4-0.40.4-0.40.40.2-0.30.3
Reaction time num false alarms0.20.31.2-0.7-1.1-0.6-0.40.1-0.50.5-0.5-0.50.5-0.50.5-0.20.5-0.6
Reaction time num false alarms AUC0.20.32.1-1.0-1.4-0.9-0.70.3-0.30.3-0.0-0.00.0-0.00.0-0.00.4-0.4
Reaction time trials correct on left0.30.51.30.20.10.80.9-1.1-1.01.0-0.5-0.50.5-0.50.5-0.90.9-0.8
Reaction time trials on left0.30.61.30.20.10.90.9-1.1-1.01.0-0.5-0.50.5-0.50.5-0.90.9-0.9
Reaction time mean0.81.22.7-0.4-0.1-1.2-1.21.41.6-1.60.60.6-0.60.6-0.61.4-1.41.4
Reaction time mean AUC0.71.12.2-0.5-0.5-1.2-1.31.21.5-1.50.60.6-0.60.6-0.61.2-1.21.2
Median of all reaction times1.42.03.8-0.5-0.6-1.6-1.71.72.0-2.01.01.0-1.01.0-1.01.7-1.61.6
Reaction time omissions0.60.81.8-0.6-0.30.40.3-0.6-0.40.4-1.4-1.41.4-1.41.4-0.80.7-0.7
Reaction time false alarm rate0.20.31.4-0.7-1.2-1.1-1.00.70.2-0.20.10.1-0.10.1-0.10.4-0.00.0
Reaction time premature initiation rate0.50.71.0-0.1-0.8-0.8-1.00.60.7-0.71.01.0-1.01.0-1.00.7-0.60.6
Reaction time premature initiations0.10.20.5-0.0-0.5-0.2-0.4-0.00.2-0.20.70.7-0.70.7-0.70.2-0.20.2
Std. dev. reaction times0.10.20.4-0.40.1-0.4-0.30.30.6-0.6-0.3-0.30.3-0.30.30.5-0.60.6
Reaction time trials completed0.30.61.30.20.10.90.9-1.1-1.01.0-0.5-0.50.5-0.50.5-0.90.9-0.9
Reaction time trials AUC0.20.40.9-0.1-0.10.60.7-1.0-0.90.9-0.5-0.50.5-0.50.5-0.70.8-0.8
Run reversals in cocaine runway, females3.23.14.71.20.51.91.7-1.9-1.81.8-1.8-1.81.8-1.81.8-2.21.9-1.9
Run reversals in cocaine runway, males3.33.35.10.10.6-1.4-1.22.01.9-1.92.02.0-2.02.0-2.02.3-2.22.2
Latency to leave start box in cocaine runway0.70.83.0-1.6-1.7-1.2-1.40.61.0-1.00.10.1-0.10.1-0.10.4-0.20.2
Latency to leave start box in cocaine runway, F0.70.81.5-0.8-1.20.0-0.0-0.6-0.40.4-1.2-1.21.2-1.21.2-0.91.0-1.0
Latency to leave start box in cocaine runway, M2.52.33.9-1.3-1.4-1.8-2.01.41.8-1.81.41.4-1.41.4-1.41.5-1.41.4
Std. dev. time between licks in bursts0.81.02.0-1.3-0.2-0.6-0.70.70.8-0.81.41.4-1.41.4-1.40.3-0.60.6
Total sessions with >9 infusions0.30.30.80.4-0.30.60.4-0.9-0.60.6-0.6-0.60.6-0.60.6-0.70.7-0.7
Short access day 1 total inactive lever presses0.20.31.0-0.3-0.10.70.4-1.0-0.40.4-0.4-0.40.4-0.40.4-0.90.4-0.4
Short access day 10 total inactive lever presses0.30.81.0-0.80.5-0.4-0.50.81.0-1.01.01.0-1.01.0-1.00.8-1.01.0
Short access day 1 total infusions0.10.11.0-0.5-1.0-0.2-0.4-0.30.1-0.10.30.3-0.30.3-0.3-0.20.2-0.2
Short access day 10 total infusions0.10.20.80.90.70.60.6-0.6-0.30.30.20.2-0.20.2-0.2-0.20.0-0.0
Short access total infusions0.10.10.40.3-0.20.30.1-0.6-0.20.2-0.1-0.10.1-0.10.1-0.30.3-0.3
Short access day 1 locomotion1.11.33.30.4-0.21.41.1-1.8-1.41.4-0.6-0.60.6-0.60.6-1.81.5-1.5
Short access day 10 total locomotion0.50.91.8-0.60.8-0.0-0.10.30.7-0.71.31.3-1.31.3-1.30.4-0.90.9
Short access total locomotion0.60.81.90.51.01.41.3-1.3-0.90.9-0.5-0.50.5-0.50.5-1.10.7-0.7
One hour access (0.3 mA shock)0.10.10.5-0.0-0.7-0.3-0.2-0.2-0.20.20.20.2-0.20.2-0.20.20.2-0.2
Compulsive drug intake2.32.84.4-1.0-2.00.40.2-1.3-1.71.7-1.8-1.81.8-1.81.8-1.82.1-2.1
One hour access (shock baseline)1.82.74.10.0-0.2-1.4-1.41.51.7-1.71.91.9-1.91.9-1.92.0-1.71.7
Social response proportion0.30.41.0-0.9-0.5-1.0-0.70.80.2-0.20.50.5-0.50.5-0.50.6-0.50.5
Social responses1.31.72.9-0.4-0.4-1.2-1.21.21.0-1.01.71.7-1.71.7-1.71.1-1.21.2
Social time0.81.12.4-1.0-0.6-1.6-1.31.41.2-1.20.30.3-0.30.3-0.31.5-1.21.2
Soleus weight0.51.59.73.11.71.71.4-0.9-0.50.5-0.7-0.70.7-0.70.7-0.60.3-0.3
Bone: stiffness1.22.02.9-0.8-0.4-1.5-1.51.51.2-1.21.51.5-1.51.5-1.51.7-1.61.6
Tibialis anterior weight1.03.48.72.92.22.12.3-1.6-1.61.6-1.8-1.81.8-1.81.8-1.01.0-1.0
Time to tail flick, vehicle, before self-admin0.20.20.50.1-0.1-0.1-0.20.10.2-0.20.70.7-0.70.7-0.7-0.0-0.20.1
Time to tail flick, vehicle, after self-admin0.70.92.10.81.51.31.2-0.7-0.50.5-1.0-1.01.0-1.01.0-0.80.5-0.5
Time to tail flick, test, before self-admin1.21.21.8-0.1-0.7-1.1-1.20.81.3-1.31.21.2-1.21.2-1.21.1-1.21.2
Time to tail flick, test, after self-admin0.30.31.81.30.40.0-0.10.40.4-0.40.40.4-0.40.4-0.40.4-0.50.5
Delta time to tail flick, vehicle, before/after SA1.01.01.90.11.01.01.0-0.6-0.60.6-1.4-1.41.4-1.41.4-0.70.5-0.5
Delta time to tail flick, test, before/after SA0.70.71.81.30.51.00.9-0.7-0.90.9-0.7-0.70.7-0.70.7-0.90.8-0.8
Tibia length1.13.08.22.90.91.81.8-1.8-1.91.9-1.7-1.71.7-1.71.7-1.01.3-1.3
Ambulatory time before self-admin0.20.31.40.21.20.50.5-0.1-0.00.00.60.6-0.60.6-0.60.0-0.30.3
Ambulatory time after self-admin0.40.51.4-0.30.20.70.9-0.8-1.21.20.10.1-0.10.1-0.1-0.90.9-0.9
Bone: tissue strength0.30.32.41.50.20.60.6-0.7-0.40.4-0.2-0.20.2-0.20.2-0.20.4-0.4
Total heroin consumption1.31.53.6-0.10.5-1.2-1.11.81.8-1.80.60.6-0.60.6-0.61.9-1.61.6
Bone: trabecular number1.01.74.6-2.1-1.7-1.8-1.81.40.6-0.61.11.1-1.11.1-1.11.0-0.70.7
Bone: trabecular spacing0.81.01.51.00.41.21.1-1.2-0.80.8-1.0-1.01.0-1.01.0-1.10.9-0.9
Bone: trabecular thickness2.02.54.60.70.41.71.6-1.7-2.12.1-1.4-1.41.4-1.41.4-1.81.7-1.7
Bone: trabecular tissue density0.71.03.91.02.01.61.7-1.0-0.80.8-0.5-0.50.5-0.50.5-0.90.6-0.6
Water consumed over 24 hours0.40.51.40.2-0.5-1.0-1.00.90.9-0.90.10.1-0.10.1-0.11.2-0.90.9
Number of responses in last shaping day0.10.10.30.20.30.50.4-0.5-0.40.40.10.1-0.10.1-0.1-0.40.1-0.1