Hub : Genes

Xpo7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Xpo7 0.02 0.02 9.5e-03 0.01 0 0 0 4.0e-02 1.6e-01 1.0e-01 1.3e-01
2 PL alternative TSS NM_001108386.2 0.04 0.03 7.7e-03 0.02 0.01 0.01 0.01 4.7e-03 1.3e-02 1.3e-02 1.5e-02
3 IC gene expression Xpo7 0.77 0.13 0.0e+00 0.42 0.41 0.41 0.42 2.6e-19 1.1e-18 2.0e-18 4.6e-19
4 OFC gene expression Xpo7 0.7 0.15 7.6e-11 0.29 0.24 0.22 0.25 1.6e-07 2.2e-06 4.6e-06 1.4e-06
5 pVTA gene expression Xpo7 0.3 0.14 1.1e-16 0.22 0.22 0.22 0.22 1.1e-17 1.8e-17 3.1e-17 2.4e-17
6 BLA gene expression Xpo7 0.61 0.15 0.0e+00 0.42 0.41 0.42 0.41 1.2e-23 1.8e-23 1.1e-23 1.5e-23
7 NAcc gene expression Xpo7 0.32 0.15 0.0e+00 0.24 0.25 0.24 0.25 9.7e-37 1.9e-37 1.5e-36 8.3e-37
8 PL gene expression Xpo7 0.71 0.15 0.0e+00 0.46 0.48 0.46 0.46 8.1e-56 9.0e-59 2.6e-55 8.2e-56
9 Brain gene expression Xpo7 0.5 0.18 0.0e+00 0.38 0.4 0.4 0.4 5.0e-37 9.3e-40 3.5e-40 9.1e-40
10 Liver alternative TSS XM_063274433.1 0.02 0.02 4.5e-03 0.01 0.02 0.01 0.01 7.3e-03 3.8e-03 7.7e-03 1.4e-02
11 Liver alternative TSS NM_001108386.2 0.02 0.02 9.9e-03 0.01 0.01 0 0.01 1.3e-02 1.2e-02 1.1e-01 2.8e-02
12 IL gene expression Xpo7 0.51 0.19 1.4e-06 0.16 0.16 0.16 0.16 1.1e-04 8.9e-05 9.5e-05 1.0e-04
13 Liver gene expression Xpo7 0.15 0.09 2.2e-12 0.08 0.09 0.08 0.08 9.0e-09 6.6e-10 2.2e-09 3.7e-09
14 Adipose gene expression Xpo7 0.08 0.05 6.6e-07 0.02 0.03 0.03 0.03 6.5e-03 1.2e-04 1.1e-04 4.1e-04
15 Adipose mRNA stability Xpo7 0.04 0.03 9.2e-04 0.01 0.02 0.03 0.01 2.4e-02 5.8e-03 3.1e-04 8.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.30.52.21.20.0-0.1-0.1-0.2-0.20.20.1-0.31.5-1.50.60.6-0.7-0.7
Area under the delay curve0.20.30.90.0-0.40.90.91.00.6-0.5-0.30.6-0.20.2-0.4-0.50.50.5
BMI with tail0.41.24.1-2.01.2-1.2-1.2-1.2-0.90.91.0-0.8-1.61.50.50.4-0.20.0
BMI without tail0.52.43.9-1.41.8-1.9-1.9-2.0-1.71.71.7-1.7-0.50.31.41.4-1.4-1.4
Body weight0.20.93.2-1.3-0.40.30.30.20.6-0.6-0.50.7-1.81.8-1.0-1.01.10.8
Weight adjusted by age0.41.22.1-0.7-0.80.80.80.91.0-1.0-1.01.1-1.41.4-1.3-1.31.41.3
Bone surface0.30.62.01.4-0.70.70.70.70.6-0.6-0.60.51.3-1.2-0.2-0.20.10.2
Bone volume0.20.51.81.3-0.60.60.60.50.4-0.4-0.50.31.3-1.2-0.1-0.1-0.1-0.1
Breakpoint value in progressive ratio session0.00.10.1-0.1-0.30.30.30.30.3-0.3-0.30.3-0.20.3-0.3-0.30.30.3
Number of licking bursts0.00.10.1-0.10.3-0.3-0.3-0.3-0.30.30.3-0.3-0.10.00.30.3-0.3-0.3
Context. condit. distance diff. score7.49.012.1-1.93.5-3.4-3.4-3.5-3.43.43.4-3.40.2-0.53.23.2-3.1-2.6
Locomotion velocity, session 10.20.20.3-0.0-0.50.30.30.30.5-0.5-0.50.5-0.30.3-0.5-0.50.50.5
Locomotion distance, session 11.51.92.91.6-1.71.51.51.51.6-1.6-1.71.60.6-0.5-1.4-1.41.00.4
Locomotion velocity, session 20.60.71.21.1-0.90.90.90.90.9-0.9-1.00.90.5-0.4-0.8-0.70.60.4
Locomotion distance, session 23.44.87.22.4-2.72.52.52.52.5-2.5-2.72.40.9-0.7-2.1-2.11.71.1
Locomotion velocity, session 31.31.42.9-1.71.4-1.5-1.5-1.5-1.21.21.2-1.2-1.11.00.90.9-0.6-0.1
Locomotion distance, session 31.01.21.9-0.81.3-1.3-1.3-1.4-1.21.21.2-1.2-0.10.01.11.1-1.0-0.6
Stereotopy head waving bouts, day 30.30.30.8-0.5-0.40.40.40.20.5-0.5-0.40.5-0.80.9-0.6-0.60.70.6
Stereotopy head waving duration, day 31.11.42.8-1.0-0.90.90.90.71.0-1.0-0.91.1-1.61.7-1.3-1.31.41.3
Locomotion velocity, session 711.112.116.2-1.23.9-3.9-3.9-4.0-4.03.93.8-4.01.3-1.53.93.9-3.8-2.9
Locomotion distance, session 76.58.310.8-0.63.2-3.2-3.2-3.2-3.23.23.1-3.31.4-1.63.33.3-3.2-2.6
Stereotopy head waving bouts, day 71.41.62.3-0.3-1.21.21.21.31.3-1.3-1.21.3-1.11.2-1.4-1.41.51.5
Stereotopy head waving duration, day 71.31.62.7-0.9-1.01.11.11.11.1-1.1-1.01.2-1.51.6-1.4-1.41.61.6
Locomotion velocity, session 80.70.91.4-0.71.2-1.2-1.2-1.2-1.11.11.0-1.1-0.10.01.01.0-0.8-0.3
Locomotion distance, session 80.40.61.30.50.5-0.7-0.7-0.7-0.70.60.5-0.71.0-1.00.80.8-1.0-1.1
Degree of sensitization distance3.94.26.10.32.0-2.0-2.0-2.0-2.12.12.0-2.21.7-1.92.42.4-2.5-2.1
Degree of sensitization stereotypy0.60.71.1-0.6-0.60.70.70.70.7-0.7-0.70.8-1.01.1-0.9-0.91.01.1
Conditioned locomotion0.70.81.3-0.71.2-1.0-1.0-1.0-1.11.11.1-1.0-0.0-0.01.01.0-0.8-0.5
Cocaine response after cond. corrected1.62.43.7-1.91.9-1.8-1.8-1.9-1.71.81.8-1.7-1.00.91.41.3-1.1-0.4
Cocaine response after cond. not corrected0.81.11.7-1.21.3-1.3-1.3-1.3-1.21.21.2-1.1-0.70.60.90.9-0.7-0.2
Cocaine response before conditioning1.61.92.91.7-1.71.61.61.61.5-1.6-1.61.50.9-0.7-1.2-1.21.00.4
Saline control response0.81.11.81.3-1.31.21.21.21.2-1.2-1.21.10.7-0.6-0.9-0.90.80.5
Bone: connectivity density0.81.23.71.20.5-0.5-0.5-0.6-0.80.70.7-0.81.9-1.91.11.2-1.4-1.4
Bone: cortical apparent density2.23.44.9-1.52.2-2.2-2.2-2.2-2.12.12.1-2.1-0.30.11.91.9-1.7-1.3
Bone: cortical area0.40.70.90.9-0.90.90.90.90.9-0.9-1.00.80.4-0.3-0.7-0.70.71.0
Bone: cortical porosity2.42.63.40.4-1.71.71.71.81.8-1.8-1.81.8-0.70.8-1.8-1.81.81.6
Bone: cortical porosity2.62.84.00.8-1.91.91.92.01.9-1.9-1.91.9-0.40.5-1.9-1.81.81.5
Bone: cortical thickness0.00.10.30.4-0.20.20.20.20.2-0.2-0.30.20.2-0.2-0.1-0.10.20.6
Bone: cortical thickness1.11.42.1-1.01.4-1.3-1.3-1.3-1.31.31.3-1.3-0.30.11.21.2-1.1-0.9
Bone: cortical tissue density2.43.95.5-1.62.4-2.3-2.3-2.3-2.32.32.3-2.2-0.30.12.02.0-1.8-1.4
Condit. Reinf. active minus inactive responses0.80.91.30.2-1.11.11.11.11.1-1.1-1.11.1-0.40.5-1.1-1.11.00.8
Condit. Reinf. active-inactive response ratio0.50.62.3-1.40.0-0.1-0.1-0.00.1-0.1-0.10.2-1.51.5-0.5-0.50.61.0
Condit. Reinf. active responses1.41.72.61.3-1.61.61.61.61.5-1.5-1.51.50.4-0.3-1.3-1.31.10.7
Condit. Reinf. inactive responses2.22.89.13.0-1.81.81.81.81.5-1.5-1.61.42.3-2.1-0.9-0.80.5-0.3
Incentive salience index mean2.32.94.00.7-2.02.02.02.02.0-1.9-1.92.0-0.40.6-1.9-1.91.71.3
Condit. Reinf. lever presses2.43.55.11.4-2.22.22.22.32.2-2.1-2.22.20.00.1-2.0-2.01.81.2
Condit. Reinf. active minus inactive responses0.10.10.50.50.1-0.1-0.1-0.1-0.20.30.2-0.30.7-0.70.40.4-0.4-0.3
Condit. Reinf. active-inactive response ratio0.10.20.3-0.60.5-0.5-0.5-0.5-0.50.50.5-0.5-0.40.30.30.3-0.20.0
Condit. Reinf. active responses0.20.31.30.90.0-0.1-0.1-0.1-0.20.20.1-0.31.2-1.20.50.5-0.6-0.7
Condit. Reinf. inactive responses0.50.72.91.5-0.20.30.30.30.0-0.1-0.1-0.01.7-1.70.40.4-0.7-1.1
Condit. Reinf. lever presses1.01.42.41.4-1.41.61.61.51.3-1.3-1.31.20.8-0.7-1.0-1.00.80.1
Condit. Reinf. lever reinforcers received0.20.21.10.9-0.10.10.10.1-0.10.1-0.0-0.11.0-1.00.30.3-0.4-0.5
Conditioned reinforcement - actives0.31.42.10.31.1-1.0-1.0-1.1-1.21.21.2-1.21.1-1.21.41.4-1.5-1.4
Conditioned reinforcement - inactives0.51.46.02.3-0.70.70.70.60.4-0.4-0.50.32.4-2.40.20.2-0.6-0.9
Conditioned locomotion0.10.20.30.10.5-0.5-0.5-0.5-0.50.50.4-0.50.4-0.40.50.5-0.5-0.5
Patch foraging indifference point 0 sec1.85.111.73.4-2.62.52.52.42.3-2.3-2.42.12.5-2.3-1.5-1.51.20.8
Patch foraging indifference point AUC0.30.71.3-1.10.9-0.9-0.9-0.9-0.90.91.0-0.8-0.80.70.60.6-0.4-0.1
Delay disc. indifference point, 0s delay1.21.32.61.5-1.21.61.61.61.2-1.1-1.01.11.0-0.9-0.8-0.80.70.4
Delay disc. indifference point, 16s delay0.10.10.30.20.20.30.30.3-0.00.10.3-0.10.5-0.50.30.3-0.3-0.3
Delay disc. indifference point, 2s delay1.92.12.9-0.2-1.31.71.71.71.5-1.5-1.21.5-1.01.1-1.5-1.51.71.6
Delay disc. indifference point, 24s delay0.20.30.6-0.80.8-0.5-0.5-0.4-0.50.60.6-0.5-0.60.50.40.4-0.3-0.0
Delay disc. indifference point, 4s delay0.60.62.0-1.2-0.10.60.60.60.4-0.3-0.10.5-1.41.4-0.6-0.60.91.0
Delay disc. indifference point, 8s delay0.10.10.40.3-0.20.60.60.60.3-0.3-0.10.30.3-0.2-0.1-0.10.10.1
Indifference point function ln k0.41.11.60.9-1.31.31.31.31.2-1.2-1.21.20.4-0.3-1.0-1.00.80.4
Indifference point function log k0.41.11.60.9-1.31.31.31.31.2-1.2-1.21.20.4-0.3-1.0-1.00.80.4
Patch foraging total patch changes 0 sec1.85.110.63.3-2.72.62.62.52.4-2.4-2.52.22.2-2.0-1.7-1.61.41.0
Patch foraging total patch changes 12 sec1.31.83.71.9-1.51.61.61.61.4-1.3-1.31.31.3-1.2-0.9-0.90.80.8
Patch foraging total patch changes 18 sec0.20.62.61.6-0.30.20.20.20.1-0.1-0.20.01.6-1.60.30.3-0.5-0.4
Patch foraging total patch changes 24 sec0.82.63.81.5-2.01.91.91.91.9-1.8-1.81.80.5-0.3-1.6-1.61.51.3
Patch foraging total patch changes 6 sec0.10.20.60.8-0.40.40.40.30.3-0.3-0.30.30.7-0.6-0.1-0.10.10.2
Patch foraging time to switch 0 sec0.20.61.10.60.6-0.6-0.6-0.6-0.70.70.6-0.71.0-1.00.90.9-1.0-0.9
Patch foraging water rate 0 sec0.31.11.40.1-1.21.11.11.11.2-1.2-1.21.2-0.50.6-1.2-1.21.10.9
Patch foraging water rate 12 sec0.31.01.80.0-1.01.01.00.91.1-1.0-1.11.1-0.70.8-1.2-1.21.21.4
Patch foraging water rate 18 sec0.51.14.7-1.8-0.1-0.0-0.0-0.00.3-0.3-0.20.4-2.22.2-0.8-0.81.01.1
Patch foraging water rate 24 sec0.40.61.1-1.00.8-0.9-0.9-1.0-0.80.70.7-0.7-0.70.60.50.5-0.4-0.3
Patch foraging water rate 6 sec2.63.95.20.0-2.02.02.02.12.1-2.1-2.12.2-1.21.4-2.2-2.22.32.2
Seeking ratio, delayed vs. immediate footshock0.20.31.51.2-0.40.30.30.30.2-0.3-0.40.21.2-1.10.00.0-0.2-0.4
Distance traveled before self-admin1.43.03.80.6-1.92.02.01.92.0-1.9-1.92.0-0.60.7-1.9-1.91.91.7
Distance traveled after self-admin0.50.83.4-1.60.00.00.00.10.2-0.2-0.10.3-1.81.8-0.6-0.60.91.0
Extensor digitorum longus weight4.116.350.5-4.7-1.81.81.81.72.5-2.5-2.32.9-7.07.1-4.0-4.14.95.2
Bone: elastic displacement0.70.82.31.5-1.01.01.01.10.9-0.9-0.90.81.0-0.9-0.6-0.60.30.0
Bone: elastic work2.43.15.02.2-2.12.12.12.11.9-1.9-2.01.81.1-1.0-1.5-1.51.20.8
Bone: endosteal estimation0.30.81.10.5-1.01.01.01.01.0-1.1-1.01.0-0.10.2-1.0-1.01.00.9
Bone: endosteal perimeter0.71.72.30.9-1.51.51.51.51.5-1.5-1.51.40.10.0-1.3-1.31.31.1
Epididymis fat weight0.21.13.01.00.5-0.8-0.8-0.7-0.80.70.5-0.81.6-1.61.01.0-1.4-1.7
Delta time in closed arm before/after self-admin1.21.24.92.2-0.70.70.70.60.4-0.4-0.50.32.2-2.10.10.2-0.5-0.8
Delta time in open arm before/after self-admin0.10.10.2-0.40.3-0.2-0.2-0.2-0.20.20.3-0.2-0.40.30.10.1-0.00.0
Diff in mean of infusions in LGA sessions0.30.51.0-0.6-0.50.50.50.50.6-0.6-0.50.6-1.01.0-0.7-0.70.80.9
Delay discount exponential model param0.30.51.00.30.4-1.0-1.0-1.0-0.70.60.3-0.70.5-0.60.60.6-0.7-0.7
Extinction: sum of active levers before priming0.40.62.61.30.1-0.1-0.1-0.2-0.30.30.2-0.41.6-1.60.70.7-0.9-1.0
Active lever presses in extinction session 60.70.71.00.10.9-0.9-0.9-0.7-0.90.90.8-0.90.7-0.71.01.0-1.0-1.0
Bone: final force0.20.40.60.3-0.60.60.60.60.7-0.7-0.70.6-0.20.3-0.7-0.70.70.8
Bone: final moment0.60.91.30.7-1.11.11.11.11.1-1.1-1.21.0-0.00.1-1.0-1.01.01.1
Food consumed during 24 hour testing period0.50.91.91.4-1.11.11.11.11.0-1.0-1.00.90.9-0.8-0.7-0.70.40.0
Glucose0.61.01.6-1.11.2-1.1-1.1-1.2-1.11.11.2-1.1-0.30.31.01.0-0.8-0.5
Heart weight0.20.31.31.1-0.50.50.50.50.4-0.4-0.40.30.9-0.9-0.1-0.10.10.2
Delay discount hyperbolic model param0.40.61.10.30.5-1.0-1.0-1.1-0.80.70.4-0.80.6-0.70.70.7-0.8-0.8
Intermittent access intake day 1-15 change0.21.33.41.00.7-0.5-0.5-0.5-0.80.80.9-0.91.8-1.81.31.3-1.4-1.5
Intermittent access intake escalation0.21.03.81.30.3-0.1-0.1-0.1-0.50.50.5-0.61.9-1.91.01.0-1.2-1.3
Intermittent access intake escalation 20.61.11.90.30.9-0.7-0.7-0.7-1.01.01.1-1.01.1-1.21.31.3-1.4-1.3
Intermitt. access day 1 inactive lever presses0.00.20.3-0.40.5-0.4-0.4-0.3-0.50.50.6-0.4-0.0-0.00.50.5-0.5-0.4
Intermitt. access day 15 inactive lever presses0.00.10.20.4-0.30.40.40.40.3-0.3-0.30.30.3-0.3-0.2-0.20.20.0
Intermitt. access escalation Index0.10.20.50.1-0.50.70.70.60.6-0.5-0.40.6-0.10.1-0.5-0.50.40.4
Intermittent access day 1 total infusions0.00.00.00.1-0.10.20.20.10.1-0.1-0.20.10.1-0.0-0.1-0.10.10.1
Intermittent access day 15 total infusions0.30.73.01.4-0.00.20.20.2-0.10.10.1-0.21.7-1.70.50.5-0.7-0.9
Intermittent access terminal intake (last 3 days)0.50.81.30.40.7-0.6-0.6-0.6-0.80.80.8-0.91.1-1.11.01.1-1.2-1.1
Intermittent access total infusions0.60.71.40.60.6-0.6-0.6-0.6-0.70.70.7-0.81.1-1.21.01.0-1.1-1.1
Intermittent access day 1 locomotion0.30.60.90.7-0.90.90.91.00.9-0.9-0.90.80.3-0.3-0.7-0.70.60.5
Intermittent access day 15 total locomotion0.10.30.50.20.5-0.5-0.5-0.5-0.60.50.5-0.60.6-0.60.60.6-0.7-0.7
Intermittent access total locomotion0.00.00.20.30.0-0.0-0.00.0-0.00.0-0.0-0.10.4-0.40.10.2-0.2-0.2
Intermittent access standard deviation0.00.10.40.5-0.20.30.30.40.1-0.1-0.10.10.6-0.60.10.1-0.2-0.3
Left kidney weight0.21.21.90.6-1.41.21.21.01.3-1.4-1.31.3-0.20.3-1.3-1.31.10.7
Right kidney weight0.64.05.81.6-2.42.22.22.22.3-2.4-2.32.30.2-0.1-2.1-2.12.01.7
Cocaine induced anxiety1.33.75.31.6-2.32.32.32.32.2-2.2-2.22.20.5-0.3-1.9-1.91.71.3
Post-drug Anxiety2.12.44.62.1-1.81.81.81.81.6-1.6-1.61.51.5-1.3-1.1-1.10.90.4
Baseline Anxiety0.71.21.5-0.31.2-1.2-1.2-1.2-1.21.21.2-1.20.5-0.51.21.2-1.2-1.1
Tail length0.21.24.32.1-1.11.01.00.90.9-0.9-0.90.81.7-1.6-0.4-0.40.0-0.4
Length with tail0.62.84.01.1-2.01.91.91.82.0-2.0-1.92.0-0.10.2-1.8-1.81.71.2
Length without tail0.94.77.3-1.1-1.81.81.81.82.1-2.1-1.92.2-2.52.6-2.5-2.52.72.6
Times rat made contact with spout0.40.50.80.40.6-0.6-0.6-0.6-0.70.60.6-0.70.7-0.70.70.7-0.9-0.9
Lifetime Intake0.40.50.80.40.6-0.6-0.6-0.6-0.70.70.6-0.70.9-0.90.80.8-0.9-0.9
Liver weight, left2.44.26.10.3-2.22.12.12.12.3-2.3-2.32.4-1.31.4-2.5-2.52.31.6
Liver weight, right0.10.21.0-0.90.0-0.1-0.1-0.20.0-0.10.00.1-1.01.0-0.3-0.30.20.0
Locomotor activity9.114.220.31.8-4.34.44.44.54.3-4.3-4.24.3-0.71.0-4.1-4.13.92.8
Locomotor testing distance4.511.117.53.2-4.04.14.14.23.8-3.8-3.73.71.1-0.8-3.2-3.22.71.6
Locomotor testing rearing3.914.221.93.8-4.64.64.64.74.3-4.3-4.24.21.6-1.2-3.5-3.53.01.7
Locomotion in novel chamber0.20.20.91.0-0.30.40.40.40.3-0.2-0.30.20.9-0.90.00.0-0.1-0.3
Locomotion in novel chamber post-restriction0.10.31.1-0.6-0.10.00.00.30.3-0.2-0.30.3-1.11.1-0.5-0.50.70.9
Fecal boli incidents, locomotor time 10.41.21.7-0.2-1.11.11.11.11.1-1.1-1.01.2-1.01.0-1.2-1.21.31.3
Change in fecal boli incidents, locomotor task0.30.31.1-1.10.7-0.7-0.7-0.6-0.50.50.5-0.5-0.70.60.30.3-0.2-0.1
Time >=10cm from walls, locomotor time 10.30.31.51.2-0.10.10.1-0.0-0.0-0.0-0.2-0.11.2-1.20.20.3-0.5-0.6
Bouts of movement, locomotor time 11.01.36.0-2.10.2-0.2-0.2-0.10.1-0.10.10.2-2.42.4-0.7-0.71.01.2
Total resting periods, locomotor time 11.31.56.3-2.40.6-0.7-0.7-0.7-0.40.40.4-0.2-2.52.4-0.3-0.30.70.9
Rest time, locomotor task time 10.50.73.0-1.70.5-0.6-0.6-0.6-0.30.40.4-0.3-1.71.7-0.1-0.10.40.6
Distance moved, locomotor task time 10.41.13.71.40.4-0.3-0.3-0.4-0.50.50.4-0.61.9-1.90.91.0-1.2-1.3
Vertical activity count, locomotor time 10.21.43.81.9-1.31.31.31.31.2-1.2-1.31.11.4-1.3-0.8-0.70.50.2
Time >=10cm from walls, locomotor time 20.00.10.5-0.40.0-0.1-0.1-0.10.1-0.1-0.20.1-0.70.7-0.3-0.30.30.5
Bouts of movement, locomotor time 20.41.46.4-2.40.40.00.00.10.00.00.50.1-2.52.5-0.5-0.50.91.2
Total resting periods, locomotor time 20.41.67.1-2.60.4-0.0-0.00.1-0.00.10.50.1-2.72.6-0.4-0.50.91.3
Rest time, locomotor task time 20.71.23.8-2.01.2-1.0-1.0-1.0-1.01.01.1-0.9-1.51.40.60.6-0.30.1
Distance moved, locomotor task time 21.01.45.82.4-0.80.80.80.70.6-0.7-0.80.52.3-2.2-0.0-0.0-0.3-0.7
Vertical activity count, locomotor time 20.71.63.41.9-1.61.31.31.31.4-1.4-1.51.31.1-1.0-1.0-1.00.80.5
Light reinforcement 10.73.36.70.81.6-1.4-1.4-1.4-1.71.71.6-1.82.0-2.12.12.1-2.3-2.6
Light reinforcement 22.65.97.8-1.12.8-2.7-2.7-2.7-2.82.82.7-2.80.5-0.72.62.6-2.6-2.2
Bone: marrow area0.30.81.00.6-1.01.01.01.01.0-1.0-1.01.0-0.00.1-0.9-0.90.90.8
Bone: maximum diameter0.20.31.6-0.2-0.20.30.30.30.4-0.4-0.40.4-0.70.7-0.5-0.50.81.3
Bone: maximum force0.81.52.50.6-1.31.31.31.31.4-1.3-1.41.3-0.30.4-1.3-1.31.41.6
Bone: maximum moment1.32.53.61.2-1.81.71.71.71.8-1.8-1.91.7-0.00.1-1.7-1.61.71.8
Mean time between licks in bursts0.20.93.81.9-0.20.30.30.3-0.00.0-0.1-0.01.9-1.80.40.4-0.9-1.3
Mean num. licks in bursts0.00.10.30.30.2-0.2-0.2-0.2-0.30.30.2-0.30.6-0.60.40.4-0.4-0.4
Cd content in liver1.61.72.50.1-1.31.31.31.41.4-1.4-1.41.4-0.80.9-1.5-1.51.61.5
Co content in liver1.41.77.0-2.60.5-0.5-0.5-0.4-0.20.20.3-0.0-2.62.6-0.4-0.50.91.5
Cu content in liver0.10.10.6-0.80.3-0.2-0.2-0.1-0.10.20.2-0.1-0.70.7-0.0-0.00.20.5
Fe content in liver0.40.52.11.20.2-0.1-0.1-0.2-0.30.30.2-0.41.4-1.40.60.6-0.7-0.5
K content in liver0.90.81.30.20.9-0.7-0.7-0.8-0.91.01.0-1.00.9-1.01.11.1-1.1-0.9
Mg content in liver1.11.22.60.90.8-0.7-0.7-0.9-0.90.90.9-1.01.6-1.61.21.2-1.4-1.4
Mn content in liver0.60.73.11.40.00.00.00.1-0.20.20.2-0.31.8-1.70.60.7-0.8-0.9
Na content in liver4.65.27.81.0-2.52.82.82.82.6-2.5-2.42.6-0.40.6-2.4-2.42.42.1
Rb content in liver0.70.81.3-0.71.1-1.1-1.1-1.1-1.01.11.0-1.0-0.10.00.90.9-0.8-0.4
Se content in liver3.84.58.12.9-2.52.62.62.62.3-2.3-2.32.21.8-1.6-1.7-1.61.20.5
Sr content in liver0.20.20.30.5-0.50.50.50.50.5-0.5-0.50.40.3-0.3-0.3-0.30.40.5
Zn content in liver0.70.81.41.2-1.11.11.11.01.0-1.0-1.00.90.7-0.6-0.7-0.70.60.5
Bone: minimum diameter1.22.33.21.1-1.71.71.71.71.7-1.7-1.81.7-0.00.1-1.6-1.61.61.6
Time in familiar zone, hab. session 10.20.20.4-0.60.6-0.6-0.6-0.6-0.50.50.5-0.5-0.30.30.40.4-0.30.1
Time in novel zone, hab. session 10.40.41.9-1.40.5-0.4-0.4-0.4-0.30.30.4-0.2-1.31.30.0-0.00.20.4
Total zone transitions, hab. session 10.91.21.80.7-1.31.31.31.31.3-1.3-1.31.3-0.10.2-1.2-1.21.10.8
Total locomotion distance, hab. session 11.31.92.71.5-1.61.61.61.61.6-1.5-1.61.50.6-0.4-1.3-1.31.10.8
Locomotion velocity, hab. session 12.63.75.42.3-2.32.32.32.32.2-2.2-2.22.11.0-0.9-1.8-1.71.40.8
Time in familiar zone, hab. session 21.71.95.2-2.31.5-1.5-1.5-1.5-1.31.31.3-1.2-1.81.70.80.7-0.40.4
Time in novel zone, hab. session 20.70.81.91.4-1.01.01.01.00.9-0.9-0.80.81.1-1.0-0.5-0.50.3-0.1
Total zone transitions, hab. session 23.24.15.70.7-2.32.22.22.12.3-2.4-2.32.4-0.81.0-2.4-2.42.21.4
Total locomotion distance, hab. session 21.41.92.70.9-1.61.61.61.41.6-1.6-1.61.6-0.10.3-1.6-1.51.30.8
Locomotion velocity, hab. session 22.43.24.40.9-2.12.02.01.92.1-2.1-2.12.1-0.40.5-2.0-2.01.81.2
Novel to familiar place preference ratio0.40.52.21.5-0.50.50.50.60.4-0.4-0.40.31.4-1.4-0.0-0.0-0.2-0.6
Novelty place preference0.30.41.81.3-0.50.50.50.50.4-0.4-0.40.31.3-1.2-0.1-0.1-0.2-0.5
Time in novel zone, NPP test0.30.31.11.1-0.50.50.50.50.4-0.4-0.40.40.9-0.9-0.2-0.2-0.0-0.4
Total zone transitions, NPP test1.11.63.01.7-1.61.51.51.31.4-1.5-1.51.40.9-0.8-1.1-1.10.80.1
Total locomotion distance, NPP test1.62.38.73.0-1.51.41.41.31.2-1.2-1.41.12.4-2.3-0.6-0.60.0-0.7
Locomotion velocity, NPP test1.52.28.42.9-1.51.31.31.21.1-1.2-1.31.02.4-2.2-0.5-0.50.0-0.7
Intraocular pressure0.20.31.00.9-0.20.20.20.10.0-0.0-0.10.01.0-1.00.20.2-0.5-1.0
Delta distance traveled before/after self-admin2.42.78.2-2.91.8-1.8-1.8-1.6-1.51.51.5-1.4-2.32.10.80.8-0.40.0
Delta ambulatory time before/after self-admin1.22.17.4-2.71.5-1.5-1.5-1.3-1.21.21.2-1.0-2.32.20.50.5-0.10.3
Parametrial fat weight0.51.24.21.50.5-0.5-0.5-0.5-0.60.60.5-0.72.0-2.01.11.1-1.3-1.3
Pavlov. Cond. lever latency0.60.81.1-0.91.0-1.0-1.0-1.0-1.01.01.1-1.0-0.30.30.80.8-0.7-0.4
Pavlov. Cond. magazine entry latency0.00.00.10.2-0.00.10.1-0.00.0-0.0-0.10.00.2-0.20.00.0-0.1-0.1
Pavlov. Cond. change in total contacts1.61.72.30.3-1.41.41.41.31.4-1.4-1.51.5-0.70.8-1.5-1.51.41.1
Pavlov. Cond. index score0.40.60.90.5-0.90.90.90.80.9-0.9-0.90.90.00.1-0.8-0.80.70.5
Pavlov. Cond. latency score0.50.60.90.7-0.90.90.90.90.9-0.9-1.00.90.1-0.1-0.8-0.80.70.5
Pavlov. Cond. lever contacts0.40.50.90.9-0.80.90.90.90.8-0.8-0.90.80.4-0.4-0.6-0.60.50.2
Pavlov. Cond. magazine entry number0.20.30.40.20.5-0.5-0.5-0.3-0.50.50.5-0.50.6-0.60.60.6-0.6-0.5
Pavlov. Cond. intertrial magazine entries1.21.42.11.4-1.41.41.41.51.3-1.3-1.31.30.7-0.6-1.1-1.00.90.5
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.4-0.90.90.90.80.9-0.9-1.00.9-0.20.2-0.9-0.90.80.6
Pavlov. Cond. response bias0.20.20.30.1-0.50.50.50.40.5-0.5-0.50.5-0.30.3-0.5-0.50.50.3
Pavlov. Cond. lever latency2.53.65.1-1.22.2-2.3-2.3-2.3-2.12.22.1-2.20.2-0.42.02.0-1.8-1.2
Pavlov. Cond. magazine entry latency0.81.21.81.3-1.31.31.31.31.2-1.2-1.21.20.6-0.5-1.0-1.00.70.2
Pavlov. Cond. change in total contacts1.12.73.60.2-1.71.81.81.81.8-1.8-1.71.8-1.01.1-1.9-1.91.91.4
Pavlov. Cond. index score2.13.34.71.1-2.12.22.22.22.1-2.1-2.02.1-0.30.4-2.0-2.01.81.1
Pavlov. Cond. latency score2.03.24.71.2-2.12.22.22.22.1-2.1-2.02.1-0.10.3-1.9-1.91.71.0
Pavlov. Cond. lever contacts2.33.44.91.4-2.22.22.22.22.1-2.1-2.12.10.00.1-2.0-2.01.71.0
Pavlov. Cond. magazine entry number0.50.71.1-0.91.0-1.0-1.0-1.0-0.91.00.9-0.9-0.40.30.80.8-0.6-0.0
Pavlov. Cond. intertrial magazine entries1.12.37.91.90.5-0.6-0.6-0.6-0.80.80.7-0.92.8-2.81.41.4-1.8-2.1
Pavlov. Cond. lever-magazine prob. diff.1.82.84.10.9-1.92.02.02.01.9-1.9-1.91.9-0.40.5-1.9-1.91.71.0
Pavlov. Cond. response bias2.73.75.41.4-2.32.32.32.32.2-2.2-2.22.2-0.00.2-2.0-2.01.81.1
Time in closed arm before self-admin0.40.72.6-1.60.6-0.6-0.6-0.5-0.40.40.5-0.3-1.61.5-0.0-0.00.30.6
Time in closed arm after self-admin0.00.00.0-0.10.1-0.1-0.1-0.0-0.10.10.0-0.0-0.10.1-0.0-0.00.00.1
Time in open arm before self-admin0.30.30.50.4-0.70.70.70.60.7-0.7-0.70.70.1-0.1-0.6-0.60.50.2
Time in open arm after self-admin0.10.10.30.4-0.50.50.50.40.4-0.5-0.40.40.3-0.2-0.3-0.30.30.1
Bone: periosteal estimation0.41.01.50.8-1.11.11.11.11.1-1.1-1.21.10.00.0-1.0-1.01.11.2
Bone: periosteal perimeter0.40.81.00.6-1.01.01.01.01.0-1.0-1.00.90.00.1-0.9-0.90.90.9
Bone: post-yield work0.50.91.3-0.31.1-1.1-1.1-1.1-1.11.01.0-1.10.3-0.31.01.0-0.9-0.7
Progressive ratio test 1 active lever presses0.61.01.7-1.11.2-1.2-1.2-1.3-1.11.11.1-1.1-0.60.50.90.9-0.8-0.5
Progressive ratio test 1 breakpoint0.61.11.7-1.31.2-1.2-1.2-1.3-1.11.11.1-1.1-0.70.60.90.9-0.7-0.5
Progressive ratio test 1 inactive lever presses0.41.11.60.21.0-0.9-0.9-1.0-1.11.11.0-1.10.9-1.01.21.2-1.3-1.3
Progressive ratio test 2 active lever presses0.40.60.9-0.60.9-0.9-0.9-1.0-0.90.90.9-0.9-0.0-0.00.80.8-0.8-0.6
Progressive ratio test 2 breakpoint0.20.30.5-0.40.6-0.7-0.7-0.7-0.60.60.6-0.6-0.0-0.00.60.6-0.6-0.5
Progressive ratio test 2 inactive lever presses0.10.20.40.30.3-0.4-0.4-0.4-0.40.40.4-0.40.6-0.60.50.5-0.6-0.6
Incentive Sensitization - Responses0.00.10.30.4-0.0-0.1-0.1-0.0-0.10.10.1-0.10.6-0.60.20.2-0.3-0.3
Incentive Sensitization - Breakpoint0.00.10.50.6-0.20.10.10.10.0-0.0-0.00.00.7-0.70.20.2-0.3-0.3
Sum of active levers in priming session hrs 5-60.70.70.9-0.60.9-0.9-0.9-1.0-0.90.91.0-0.90.0-0.10.90.9-0.8-0.9
Progressive ratio0.10.20.7-0.80.4-0.5-0.5-0.5-0.40.30.5-0.3-0.30.30.30.3-0.4-0.3
Food seeking constrained by brief footshock4.75.811.8-3.43.0-2.9-2.9-2.7-2.52.52.5-2.4-2.42.21.71.7-1.2-0.5
Seeking ratio, punishment vs. effort0.40.91.8-1.31.2-1.1-1.1-0.9-1.01.00.9-1.0-1.21.20.50.5-0.20.2
Retroperitoneal fat weight0.20.71.2-0.10.9-1.1-1.1-1.0-0.90.90.8-1.00.4-0.50.90.9-0.8-0.3
Reaction time number correct0.10.41.7-1.30.6-0.6-0.6-0.6-0.40.40.5-0.4-1.21.20.10.1-0.00.1
Reaction time mean minus median0.10.91.40.6-1.21.01.01.11.1-1.1-1.11.1-0.10.2-1.1-1.11.00.8
Reaction time mean minus median AUC0.00.30.50.3-0.70.60.60.60.6-0.7-0.60.7-0.20.2-0.6-0.60.60.3
Reaction time num false alarms0.20.30.60.2-0.80.60.60.60.7-0.7-0.70.7-0.30.3-0.7-0.70.50.0
Reaction time num false alarms AUC0.10.20.40.3-0.70.50.50.50.6-0.6-0.60.6-0.20.2-0.6-0.60.4-0.2
Reaction time trials correct on left0.10.41.7-1.30.6-0.6-0.6-0.6-0.40.40.5-0.4-1.21.20.10.1-0.00.1
Reaction time trials on left0.10.41.5-1.20.6-0.6-0.6-0.6-0.50.50.5-0.4-1.11.00.20.2-0.1-0.0
Reaction time mean0.20.30.50.2-0.70.60.60.60.6-0.7-0.70.7-0.30.3-0.7-0.70.60.3
Reaction time mean AUC0.30.60.90.2-0.90.80.80.70.9-0.9-0.90.9-0.50.5-0.9-0.90.90.6
Median of all reaction times0.10.10.1-0.0-0.30.20.20.20.3-0.3-0.40.3-0.30.4-0.4-0.40.30.1
Reaction time omissions0.61.02.51.20.5-0.6-0.6-0.6-0.70.70.6-0.81.6-1.61.01.0-1.2-1.5
Reaction time false alarm rate0.10.10.40.6-0.50.40.40.30.4-0.4-0.40.40.4-0.3-0.3-0.30.1-0.3
Reaction time premature initiation rate0.71.14.6-2.10.9-0.8-0.8-0.7-0.60.60.7-0.5-1.91.90.10.10.10.0
Reaction time premature initiations0.61.97.5-2.71.3-1.1-1.1-1.1-1.00.91.1-0.8-2.42.30.30.3-0.1-0.1
Std. dev. reaction times0.20.50.80.4-0.90.70.70.80.9-0.9-0.90.9-0.20.3-0.9-0.90.80.4
Reaction time trials completed0.10.41.5-1.20.6-0.6-0.6-0.6-0.50.50.5-0.4-1.11.00.20.2-0.1-0.0
Reaction time trials AUC0.10.41.3-1.20.6-0.6-0.6-0.6-0.50.50.5-0.4-1.01.00.20.2-0.1-0.0
Run reversals in cocaine runway, females0.70.83.21.10.1-0.2-0.2-0.3-0.40.30.3-0.41.8-1.80.80.8-1.1-1.3
Run reversals in cocaine runway, males0.70.81.7-0.7-0.30.50.50.60.7-0.6-0.70.7-1.31.3-1.0-1.01.11.3
Latency to leave start box in cocaine runway0.10.20.5-0.2-0.20.10.10.10.3-0.3-0.30.3-0.70.7-0.5-0.50.60.6
Latency to leave start box in cocaine runway, F0.50.71.5-0.5-0.60.40.40.50.7-0.6-0.60.7-1.21.2-0.9-0.91.01.1
Latency to leave start box in cocaine runway, M0.00.00.20.40.00.00.00.00.0-0.1-0.1-0.00.3-0.30.00.0-0.1-0.2
Std. dev. time between licks in bursts1.73.38.52.9-2.02.12.12.11.8-1.8-1.91.71.9-1.8-1.2-1.20.6-0.4
Total sessions with >9 infusions0.00.00.1-0.20.2-0.2-0.2-0.3-0.10.10.1-0.1-0.20.20.10.1-0.00.0
Short access day 1 total inactive lever presses0.20.50.80.8-0.80.90.90.90.8-0.7-0.70.70.6-0.5-0.5-0.50.40.2
Short access day 10 total inactive lever presses0.00.10.30.10.3-0.2-0.2-0.2-0.30.30.4-0.30.4-0.40.40.4-0.4-0.5
Short access day 1 total infusions0.20.40.6-0.60.7-0.8-0.8-0.8-0.70.70.6-0.7-0.40.30.50.5-0.4-0.2
Short access day 10 total infusions0.50.91.30.3-1.11.01.00.91.1-1.1-1.21.1-0.30.4-1.1-1.11.01.0
Short access total infusions0.00.00.10.1-0.20.20.20.20.2-0.2-0.30.2-0.10.1-0.3-0.30.30.3
Short access day 1 locomotion0.91.52.10.1-1.21.31.31.21.3-1.3-1.41.4-0.70.8-1.4-1.41.51.3
Short access day 10 total locomotion0.10.50.80.6-0.80.80.80.90.8-0.8-0.70.80.1-0.1-0.7-0.70.60.4
Short access total locomotion1.01.52.10.7-1.41.41.41.41.4-1.4-1.41.4-0.00.1-1.3-1.31.21.0
One hour access (0.3 mA shock)0.30.41.31.1-0.50.70.70.60.5-0.4-0.40.41.0-1.0-0.1-0.1-0.0-0.2
Compulsive drug intake0.60.92.51.6-1.11.11.11.01.0-1.0-1.00.91.1-1.0-0.6-0.60.50.1
One hour access (shock baseline)0.00.00.10.1-0.20.30.30.30.2-0.2-0.10.20.1-0.1-0.1-0.10.10.1
Social response proportion2.63.35.0-2.02.2-2.2-2.2-2.2-2.12.12.0-2.0-0.80.61.71.7-1.3-0.3
Social responses0.81.01.50.41.0-0.9-0.9-0.9-1.01.11.0-1.11.1-1.11.21.2-1.1-0.6
Social time0.81.32.51.6-1.31.31.31.31.2-1.2-1.21.11.0-0.9-0.8-0.80.70.4
Soleus weight0.30.94.4-1.80.2-0.2-0.2-0.30.0-0.10.00.2-2.12.1-0.6-0.60.70.6
Bone: stiffness0.40.71.8-0.4-0.60.60.60.60.8-0.8-0.80.8-0.90.9-0.9-0.91.11.4
Tibialis anterior weight3.211.026.9-3.0-2.02.02.02.02.6-2.6-2.32.8-5.15.2-3.6-3.64.24.2
Time to tail flick, vehicle, before self-admin0.50.61.00.40.6-0.6-0.6-0.6-0.70.70.6-0.70.9-1.00.90.9-1.0-1.0
Time to tail flick, vehicle, after self-admin1.02.05.2-2.31.6-1.6-1.6-1.7-1.41.41.4-1.3-1.81.60.80.8-0.5-0.1
Time to tail flick, test, before self-admin0.70.83.61.7-0.40.40.40.30.2-0.3-0.30.11.9-1.90.30.3-0.6-0.9
Time to tail flick, test, after self-admin4.04.35.7-0.22.2-2.2-2.2-2.2-2.32.32.1-2.31.2-1.32.32.3-2.4-2.1
Delta time to tail flick, vehicle, before/after SA1.01.11.8-1.41.3-1.3-1.3-1.3-1.11.11.1-1.1-0.90.80.80.8-0.7-0.4
Delta time to tail flick, test, before/after SA3.74.56.7-1.62.6-2.6-2.6-2.5-2.52.52.4-2.4-0.50.32.12.1-2.0-1.4
Tibia length2.57.117.74.2-3.03.03.03.02.7-2.7-2.92.52.8-2.6-1.8-1.81.41.0
Ambulatory time before self-admin0.61.72.40.6-1.51.51.51.51.5-1.5-1.41.5-0.20.3-1.4-1.41.41.2
Ambulatory time after self-admin1.21.96.3-1.8-0.50.60.60.60.8-0.8-0.70.9-2.52.5-1.3-1.31.61.8
Bone: tissue strength0.20.20.50.7-0.40.30.30.40.4-0.4-0.50.30.4-0.3-0.3-0.30.40.5
Total heroin consumption0.60.71.0-0.1-0.80.90.90.80.9-0.9-0.90.9-0.60.7-1.0-1.01.00.9
Bone: trabecular number0.50.93.81.50.0-0.1-0.1-0.1-0.30.30.2-0.41.9-1.90.70.8-1.0-1.2
Bone: trabecular spacing0.60.93.2-1.3-0.20.20.20.30.4-0.4-0.30.5-1.81.8-0.8-0.81.11.2
Bone: trabecular thickness0.30.51.91.4-0.40.40.40.40.2-0.2-0.30.21.4-1.30.10.1-0.4-0.6
Bone: trabecular tissue density0.71.32.0-0.5-0.91.01.01.01.1-1.1-1.01.1-1.21.3-1.3-1.31.41.4
Water consumed over 24 hours0.51.01.6-0.4-0.90.90.90.91.0-1.0-0.91.0-1.11.2-1.2-1.21.31.2
Number of responses in last shaping day0.20.30.5-0.4-0.30.40.40.30.4-0.4-0.50.5-0.70.7-0.6-0.60.70.7