Hub : Genes

Xpo7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Xpo7 0.02 0.02 9.5e-03 0.01 0 0 0 4.0e-02 1.6e-01 9.9e-02 1.3e-01
2 OFC gene expression Xpo7 0.7 0.15 7.6e-11 0.29 0.24 0.22 0.25 1.6e-07 2.2e-06 4.6e-06 1.3e-06
3 IC gene expression Xpo7 0.77 0.13 0.0e+00 0.42 0.41 0.41 0.42 2.6e-19 1.1e-18 2.0e-18 4.6e-19
4 pVTA gene expression Xpo7 0.3 0.14 1.1e-16 0.22 0.22 0.22 0.22 1.1e-17 1.8e-17 3.1e-17 2.4e-17
5 BLA gene expression Xpo7 0.61 0.15 0.0e+00 0.42 0.41 0.42 0.41 1.2e-23 1.8e-23 1.1e-23 1.5e-23
6 NAcc gene expression Xpo7 0.32 0.15 0.0e+00 0.24 0.25 0.24 0.25 9.7e-37 1.9e-37 1.5e-36 8.1e-37
7 PL gene expression Xpo7 0.71 0.15 0.0e+00 0.46 0.48 0.46 0.46 8.1e-56 9.0e-59 2.6e-55 8.3e-56
8 Brain gene expression Xpo7 0.5 0.18 0.0e+00 0.38 0.4 0.4 0.4 5.0e-37 9.3e-40 3.5e-40 9.0e-40
9 Liver alternative TSS XM_063274433.1 0.02 0.02 4.5e-03 0.01 0.02 0.01 0.01 7.3e-03 3.8e-03 7.7e-03 1.5e-02
10 Liver alternative TSS NM_001108386.2 0.02 0.02 9.9e-03 0.01 0.01 0 0.01 1.3e-02 1.2e-02 1.1e-01 3.0e-02
11 IL gene expression Xpo7 0.51 0.19 1.4e-06 0.16 0.16 0.16 0.16 1.1e-04 8.9e-05 9.5e-05 1.1e-04
12 Liver gene expression Xpo7 0.15 0.09 2.2e-12 0.08 0.09 0.08 0.08 9.0e-09 6.6e-10 2.2e-09 3.9e-09
13 Adipose gene expression Xpo7 0.08 0.05 6.6e-07 0.02 0.03 0.03 0.03 6.5e-03 1.2e-04 1.1e-04 5.1e-04
14 Adipose mRNA stability Xpo7 0.04 0.03 9.2e-04 0.01 0.02 0.03 0.01 2.4e-02 5.8e-03 3.1e-04 8.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.62.2-1.20.10.10.20.20.20.10.31.5-1.50.60.60.70.7
Area under the delay curve0.30.30.9-0.0-0.9-0.9-1.0-0.6-0.5-0.3-0.6-0.20.2-0.4-0.5-0.5-0.5
BMI with tail0.41.24.12.01.21.21.20.90.91.00.8-1.61.50.50.40.2-0.0
BMI without tail0.82.43.91.41.91.92.01.71.71.71.7-0.50.31.41.41.41.4
Body weight0.21.03.21.3-0.3-0.3-0.2-0.6-0.6-0.5-0.7-1.81.8-1.0-1.0-1.1-0.8
Weight adjusted by age0.81.32.10.7-0.8-0.8-0.9-1.0-1.0-1.0-1.1-1.41.4-1.3-1.3-1.4-1.3
Bone surface0.30.62.0-1.4-0.7-0.7-0.7-0.6-0.6-0.6-0.51.3-1.2-0.2-0.2-0.1-0.2
Bone volume0.30.51.8-1.3-0.6-0.6-0.5-0.4-0.4-0.5-0.31.3-1.2-0.1-0.10.10.1
Breakpoint value in progressive ratio session0.10.10.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.20.3-0.3-0.3-0.3-0.3
Number of licking bursts0.00.10.10.10.30.30.30.30.30.30.3-0.10.00.30.30.30.3
Context. condit. distance diff. score7.28.812.11.93.43.43.53.43.43.43.40.2-0.53.23.23.12.6
Locomotion velocity, session 10.20.20.30.0-0.3-0.3-0.3-0.5-0.5-0.5-0.5-0.30.3-0.5-0.5-0.5-0.5
Locomotion distance, session 11.41.82.9-1.6-1.5-1.5-1.5-1.6-1.6-1.7-1.60.6-0.5-1.4-1.4-1.0-0.4
Locomotion velocity, session 20.60.71.2-1.1-0.9-0.9-0.9-0.9-0.9-1.0-0.90.5-0.4-0.8-0.7-0.6-0.4
Locomotion distance, session 23.34.67.2-2.4-2.5-2.5-2.5-2.5-2.5-2.7-2.40.9-0.7-2.1-2.1-1.7-1.1
Locomotion velocity, session 31.21.42.91.71.51.51.51.21.21.21.2-1.11.00.90.90.60.1
Locomotion distance, session 31.11.11.90.81.31.31.41.21.21.21.2-0.10.01.11.11.00.6
Stereotopy head waving bouts, day 30.30.30.80.5-0.4-0.4-0.2-0.5-0.5-0.4-0.5-0.80.9-0.6-0.6-0.7-0.6
Stereotopy head waving duration, day 31.21.42.81.0-0.9-0.9-0.7-1.0-1.0-0.9-1.1-1.61.7-1.3-1.3-1.4-1.3
Locomotion velocity, session 710.911.916.21.23.93.94.04.03.93.84.01.3-1.53.93.93.82.9
Locomotion distance, session 76.58.210.80.63.23.23.23.23.23.13.31.4-1.63.33.33.22.6
Stereotopy head waving bouts, day 71.41.62.30.3-1.2-1.2-1.3-1.3-1.3-1.2-1.3-1.11.2-1.4-1.4-1.5-1.5
Stereotopy head waving duration, day 71.41.62.70.9-1.1-1.1-1.1-1.1-1.1-1.0-1.2-1.51.6-1.4-1.4-1.6-1.6
Locomotion velocity, session 80.70.91.40.71.21.21.21.11.11.01.1-0.10.01.01.00.80.3
Locomotion distance, session 80.40.61.3-0.50.70.70.70.70.60.50.71.0-1.00.80.81.01.1
Degree of sensitization distance4.14.26.1-0.32.02.02.02.12.12.02.21.7-1.92.42.42.52.1
Degree of sensitization stereotypy0.70.71.10.6-0.7-0.7-0.7-0.7-0.7-0.7-0.8-1.01.1-0.9-0.9-1.0-1.1
Conditioned locomotion0.70.81.20.71.01.01.01.11.11.11.0-0.0-0.01.01.00.80.5
Cocaine response after cond. corrected1.92.33.51.91.81.81.91.71.81.81.7-1.00.91.41.31.10.4
Cocaine response after cond. not corrected0.91.11.71.21.31.31.31.21.21.21.1-0.70.60.90.90.70.2
Cocaine response before conditioning1.51.82.8-1.7-1.6-1.6-1.6-1.5-1.6-1.6-1.50.9-0.7-1.2-1.2-1.0-0.4
Saline control response0.81.11.8-1.3-1.2-1.2-1.2-1.2-1.2-1.2-1.10.7-0.6-0.9-0.9-0.8-0.5
Bone: connectivity density0.81.33.7-1.20.50.50.60.80.70.70.81.9-1.91.11.21.41.4
Bone: cortical apparent density2.43.34.81.52.22.22.22.12.12.12.1-0.30.11.91.91.71.3
Bone: cortical area0.40.70.9-0.9-0.9-0.9-0.9-0.9-0.9-1.0-0.80.4-0.3-0.7-0.7-0.7-1.0
Bone: cortical porosity2.42.63.4-0.4-1.7-1.7-1.8-1.8-1.8-1.8-1.8-0.70.8-1.8-1.8-1.8-1.6
Bone: cortical porosity2.62.84.0-0.8-1.9-1.9-2.0-1.9-1.9-1.9-1.9-0.40.5-1.9-1.8-1.8-1.5
Bone: cortical thickness0.00.10.3-0.4-0.2-0.2-0.2-0.2-0.2-0.3-0.20.2-0.2-0.1-0.1-0.2-0.6
Bone: cortical thickness1.11.31.81.01.31.31.31.31.31.31.3-0.30.11.21.21.10.9
Bone: cortical tissue density2.83.85.51.62.32.32.32.32.32.32.2-0.30.12.02.01.81.4
Condit. Reinf. active minus inactive responses0.80.91.3-0.2-1.1-1.1-1.1-1.1-1.1-1.1-1.1-0.40.5-1.1-1.1-1.0-0.8
Condit. Reinf. active-inactive response ratio0.60.62.31.40.10.10.0-0.1-0.1-0.1-0.2-1.51.5-0.5-0.5-0.6-1.0
Condit. Reinf. active responses1.41.72.6-1.3-1.6-1.6-1.6-1.5-1.5-1.5-1.50.4-0.3-1.3-1.3-1.1-0.7
Condit. Reinf. inactive responses2.32.89.1-3.0-1.8-1.8-1.8-1.5-1.5-1.6-1.42.3-2.1-0.9-0.8-0.50.3
Incentive salience index mean2.32.84.0-0.7-2.0-2.0-2.0-2.0-1.9-1.9-2.0-0.40.6-1.9-1.9-1.7-1.3
Condit. Reinf. lever presses2.53.45.1-1.4-2.2-2.2-2.3-2.2-2.1-2.2-2.20.00.1-2.0-2.0-1.8-1.2
Condit. Reinf. active minus inactive responses0.10.10.5-0.50.10.10.10.20.30.20.30.7-0.70.40.40.40.3
Condit. Reinf. active-inactive response ratio0.20.20.30.60.50.50.50.50.50.50.5-0.40.30.30.30.2-0.0
Condit. Reinf. active responses0.30.41.3-0.90.10.10.10.20.20.10.31.2-1.20.50.50.60.7
Condit. Reinf. inactive responses0.60.72.9-1.5-0.3-0.3-0.3-0.0-0.1-0.10.01.7-1.70.40.40.71.1
Condit. Reinf. lever presses1.01.42.4-1.4-1.6-1.6-1.5-1.3-1.3-1.3-1.20.8-0.7-1.0-1.0-0.8-0.1
Condit. Reinf. lever reinforcers received0.20.31.1-0.9-0.1-0.1-0.10.10.1-0.00.11.0-1.00.30.30.40.5
Conditioned reinforcement - actives0.81.42.1-0.31.01.01.11.21.21.21.21.1-1.21.41.41.51.4
Conditioned reinforcement - inactives1.01.56.0-2.3-0.7-0.7-0.6-0.4-0.4-0.5-0.32.4-2.40.20.20.60.9
Conditioned locomotion0.20.20.3-0.10.50.50.50.50.50.40.50.4-0.40.50.50.50.5
Patch foraging indifference point 0 sec2.74.911.7-3.4-2.5-2.5-2.4-2.3-2.3-2.4-2.12.5-2.3-1.5-1.5-1.2-0.8
Patch foraging indifference point AUC0.40.61.31.10.90.90.90.90.91.00.8-0.80.70.60.60.40.1
Delay disc. indifference point, 0s delay1.21.32.6-1.5-1.6-1.6-1.6-1.2-1.1-1.0-1.11.0-0.9-0.8-0.8-0.7-0.4
Delay disc. indifference point, 16s delay0.10.10.3-0.2-0.3-0.3-0.30.00.10.30.10.5-0.50.30.30.30.3
Delay disc. indifference point, 2s delay1.92.12.90.2-1.7-1.7-1.7-1.5-1.5-1.2-1.5-1.01.1-1.5-1.5-1.7-1.6
Delay disc. indifference point, 24s delay0.20.30.60.80.50.50.40.50.60.60.5-0.60.50.40.40.30.0
Delay disc. indifference point, 4s delay0.60.72.01.2-0.6-0.6-0.6-0.4-0.3-0.1-0.5-1.41.4-0.6-0.6-0.9-1.0
Delay disc. indifference point, 8s delay0.10.10.4-0.3-0.6-0.6-0.6-0.3-0.3-0.1-0.30.3-0.2-0.1-0.1-0.1-0.1
Indifference point function ln k0.61.11.6-0.9-1.3-1.3-1.3-1.2-1.2-1.2-1.20.4-0.3-1.0-1.0-0.8-0.4
Indifference point function log k0.61.11.6-0.9-1.3-1.3-1.3-1.2-1.2-1.2-1.20.4-0.3-1.0-1.0-0.8-0.4
Patch foraging total patch changes 0 sec2.75.010.6-3.3-2.6-2.6-2.5-2.4-2.4-2.5-2.22.2-2.0-1.7-1.6-1.4-1.0
Patch foraging total patch changes 12 sec1.31.73.7-1.9-1.6-1.6-1.6-1.4-1.3-1.3-1.31.3-1.2-0.9-0.9-0.8-0.8
Patch foraging total patch changes 18 sec0.40.62.6-1.6-0.2-0.2-0.2-0.1-0.1-0.2-0.01.6-1.60.30.30.50.4
Patch foraging total patch changes 24 sec1.52.53.5-1.5-1.9-1.9-1.9-1.9-1.8-1.8-1.80.5-0.3-1.6-1.6-1.5-1.3
Patch foraging total patch changes 6 sec0.10.20.6-0.8-0.4-0.4-0.3-0.3-0.3-0.3-0.30.7-0.6-0.1-0.1-0.1-0.2
Patch foraging time to switch 0 sec0.30.61.1-0.60.60.60.60.70.70.60.71.0-1.00.90.91.00.9
Patch foraging water rate 0 sec0.51.01.4-0.1-1.1-1.1-1.1-1.2-1.2-1.2-1.2-0.50.6-1.2-1.2-1.1-0.9
Patch foraging water rate 12 sec0.51.01.8-0.0-1.0-1.0-0.9-1.1-1.0-1.1-1.1-0.70.8-1.2-1.2-1.2-1.4
Patch foraging water rate 18 sec0.81.24.71.80.00.00.0-0.3-0.3-0.2-0.4-2.22.2-0.8-0.8-1.0-1.2
Patch foraging water rate 24 sec0.40.51.11.00.90.91.00.80.70.70.7-0.70.60.50.50.40.3
Patch foraging water rate 6 sec2.73.95.2-0.0-2.0-2.0-2.1-2.1-2.1-2.1-2.2-1.21.4-2.2-2.2-2.3-2.2
Seeking ratio, delayed vs. immediate footshock0.30.41.5-1.2-0.3-0.3-0.3-0.2-0.3-0.4-0.21.2-1.10.00.00.20.4
Distance traveled before self-admin2.22.93.8-0.6-2.0-2.0-1.9-2.0-1.9-1.9-2.0-0.60.7-1.9-1.9-1.9-1.7
Distance traveled after self-admin0.70.93.41.6-0.0-0.0-0.1-0.2-0.2-0.1-0.3-1.81.8-0.6-0.6-0.9-1.0
Extensor digitorum longus weight4.417.250.54.7-1.8-1.8-1.7-2.5-2.5-2.3-2.9-7.07.1-4.0-4.1-4.9-5.2
Bone: elastic displacement0.70.82.3-1.5-1.0-1.0-1.1-0.9-0.9-0.9-0.81.0-0.9-0.6-0.6-0.3-0.0
Bone: elastic work2.33.05.0-2.2-2.1-2.1-2.1-1.9-1.9-2.0-1.81.1-1.0-1.5-1.5-1.2-0.8
Bone: endosteal estimation0.40.81.1-0.5-1.0-1.0-1.0-1.0-1.1-1.0-1.0-0.10.2-1.0-1.0-1.0-0.9
Bone: endosteal perimeter0.81.62.2-0.9-1.5-1.5-1.5-1.5-1.5-1.5-1.40.10.0-1.3-1.3-1.3-1.1
Epididymis fat weight0.41.23.0-1.00.80.80.70.80.70.50.81.6-1.61.01.01.41.7
Delta time in closed arm before/after self-admin1.31.24.9-2.2-0.7-0.7-0.6-0.4-0.4-0.5-0.32.2-2.10.10.20.50.8
Delta time in open arm before/after self-admin0.10.10.20.40.20.20.20.20.20.30.2-0.40.30.10.10.0-0.0
Diff in mean of infusions in LGA sessions0.40.51.00.6-0.5-0.5-0.5-0.6-0.6-0.5-0.6-1.01.0-0.7-0.7-0.8-0.9
Delay discount exponential model param0.40.51.0-0.31.01.01.00.70.60.30.70.5-0.60.60.60.70.7
Extinction: sum of active levers before priming0.60.72.6-1.30.10.10.20.30.30.20.41.6-1.60.70.70.91.0
Active lever presses in extinction session 60.70.71.0-0.10.90.90.70.90.90.80.90.7-0.71.01.01.01.0
Bone: final force0.20.40.6-0.3-0.6-0.6-0.6-0.7-0.7-0.7-0.6-0.20.3-0.7-0.7-0.7-0.8
Bone: final moment0.60.91.3-0.7-1.1-1.1-1.1-1.1-1.1-1.2-1.0-0.00.1-1.0-1.0-1.0-1.1
Food consumed during 24 hour testing period0.60.91.9-1.4-1.1-1.1-1.1-1.0-1.0-1.0-0.90.9-0.8-0.7-0.7-0.4-0.0
Glucose0.61.01.61.11.11.11.21.11.11.21.1-0.30.31.01.00.80.5
Heart weight0.20.31.3-1.1-0.5-0.5-0.5-0.4-0.4-0.4-0.30.9-0.9-0.1-0.1-0.1-0.2
Delay discount hyperbolic model param0.50.61.1-0.31.01.01.10.80.70.40.80.6-0.70.70.70.80.8
Intermittent access intake day 1-15 change0.71.33.4-1.00.50.50.50.80.80.90.91.8-1.81.31.31.41.5
Intermittent access intake escalation0.51.13.8-1.30.10.10.10.50.50.50.61.9-1.91.01.01.21.3
Intermittent access intake escalation 21.01.11.9-0.30.70.70.71.01.01.11.01.1-1.21.31.31.41.3
Intermitt. access day 1 inactive lever presses0.00.20.30.40.40.40.30.50.50.60.4-0.0-0.00.50.50.50.4
Intermitt. access day 15 inactive lever presses0.00.10.2-0.4-0.4-0.4-0.4-0.3-0.3-0.3-0.30.3-0.3-0.2-0.2-0.2-0.0
Intermitt. access escalation Index0.20.20.5-0.1-0.7-0.7-0.6-0.6-0.5-0.4-0.6-0.10.1-0.5-0.5-0.4-0.4
Intermittent access day 1 total infusions0.00.00.0-0.1-0.2-0.2-0.1-0.1-0.1-0.2-0.10.1-0.0-0.1-0.1-0.1-0.1
Intermittent access day 15 total infusions0.50.73.0-1.4-0.2-0.2-0.20.10.10.10.21.7-1.70.50.50.70.9
Intermittent access terminal intake (last 3 days)0.60.81.3-0.40.60.60.60.80.80.80.91.1-1.11.01.11.21.1
Intermittent access total infusions0.60.71.4-0.60.60.60.60.70.70.70.81.1-1.21.01.01.11.1
Intermittent access day 1 locomotion0.50.60.9-0.7-0.9-0.9-1.0-0.9-0.9-0.9-0.80.3-0.3-0.7-0.7-0.6-0.5
Intermittent access day 15 total locomotion0.20.30.5-0.20.50.50.50.60.50.50.60.6-0.60.60.60.70.7
Intermittent access total locomotion0.00.00.2-0.30.00.0-0.00.00.0-0.00.10.4-0.40.10.20.20.2
Intermittent access standard deviation0.10.10.4-0.5-0.3-0.3-0.4-0.1-0.1-0.1-0.10.6-0.60.10.10.20.2
Left kidney weight0.31.21.9-0.6-1.2-1.2-1.0-1.3-1.4-1.3-1.3-0.20.3-1.3-1.3-1.1-0.7
Right kidney weight0.93.95.6-1.6-2.2-2.2-2.2-2.4-2.4-2.3-2.30.2-0.1-2.1-2.1-2.0-1.7
Cocaine induced anxiety2.53.55.3-1.6-2.3-2.3-2.3-2.2-2.2-2.2-2.10.5-0.3-1.9-1.9-1.7-1.3
Post-drug Anxiety2.12.34.6-2.1-1.8-1.8-1.8-1.6-1.6-1.6-1.51.5-1.3-1.1-1.1-0.9-0.4
Baseline Anxiety1.01.21.50.31.21.21.21.21.21.21.20.5-0.51.21.21.21.1
Tail length0.31.14.3-2.1-1.0-1.0-0.9-0.9-0.9-0.9-0.81.7-1.6-0.4-0.4-0.00.4
Length with tail0.62.74.0-1.1-1.9-1.9-1.8-2.0-2.0-1.9-2.0-0.10.2-1.8-1.8-1.7-1.2
Length without tail1.54.87.31.1-1.8-1.8-1.8-2.1-2.1-1.9-2.2-2.52.6-2.5-2.5-2.7-2.6
Times rat made contact with spout0.40.50.8-0.40.60.60.60.70.60.60.70.7-0.70.70.70.90.9
Lifetime Intake0.40.50.8-0.40.60.60.60.70.70.60.70.9-0.90.80.80.90.9
Liver weight, left2.54.26.1-0.3-2.1-2.1-2.1-2.3-2.3-2.3-2.4-1.31.4-2.5-2.5-2.3-1.6
Liver weight, right0.10.21.00.90.10.10.2-0.0-0.10.0-0.1-1.01.0-0.3-0.3-0.2-0.0
Locomotor activity8.913.820.3-1.8-4.4-4.4-4.5-4.3-4.3-4.2-4.3-0.71.0-4.1-4.1-3.9-2.8
Locomotor testing distance6.010.717.5-3.2-4.1-4.1-4.2-3.8-3.8-3.7-3.71.1-0.8-3.2-3.2-2.7-1.6
Locomotor testing rearing6.813.721.9-3.8-4.6-4.6-4.7-4.3-4.3-4.2-4.21.6-1.2-3.5-3.5-3.0-1.7
Locomotion in novel chamber0.20.30.9-1.0-0.4-0.4-0.4-0.3-0.2-0.3-0.20.9-0.90.00.00.10.3
Locomotion in novel chamber post-restriction0.20.31.10.6-0.0-0.0-0.3-0.3-0.2-0.3-0.3-1.11.1-0.5-0.5-0.7-0.9
Fecal boli incidents, locomotor time 10.81.21.70.2-1.1-1.1-1.1-1.1-1.1-1.0-1.2-1.01.0-1.2-1.2-1.3-1.3
Change in fecal boli incidents, locomotor task0.30.31.11.10.70.70.60.50.50.50.5-0.70.60.30.30.20.1
Time >=10cm from walls, locomotor time 10.30.41.5-1.2-0.1-0.10.00.0-0.0-0.20.11.2-1.20.20.30.50.6
Bouts of movement, locomotor time 11.31.46.02.10.20.20.1-0.1-0.10.1-0.2-2.42.4-0.7-0.7-1.0-1.2
Total resting periods, locomotor time 11.41.56.32.40.70.70.70.40.40.40.2-2.52.4-0.3-0.3-0.7-0.9
Rest time, locomotor task time 10.60.83.01.70.60.60.60.30.40.40.3-1.71.7-0.1-0.1-0.4-0.6
Distance moved, locomotor task time 10.71.13.7-1.40.30.30.40.50.50.40.61.9-1.90.91.01.21.3
Vertical activity count, locomotor time 10.61.43.8-1.9-1.3-1.3-1.3-1.2-1.2-1.3-1.11.4-1.3-0.8-0.7-0.5-0.2
Time >=10cm from walls, locomotor time 20.10.10.50.40.10.10.1-0.1-0.1-0.2-0.1-0.70.7-0.3-0.3-0.3-0.5
Bouts of movement, locomotor time 21.01.56.42.4-0.0-0.0-0.1-0.00.00.5-0.1-2.52.5-0.5-0.5-0.9-1.2
Total resting periods, locomotor time 21.01.77.12.60.00.0-0.10.00.10.5-0.1-2.72.6-0.4-0.5-0.9-1.3
Rest time, locomotor task time 20.91.13.82.01.01.01.01.01.01.10.9-1.51.40.60.60.3-0.1
Distance moved, locomotor task time 21.21.45.8-2.4-0.8-0.8-0.7-0.6-0.7-0.8-0.52.3-2.2-0.0-0.00.30.7
Vertical activity count, locomotor time 21.11.63.4-1.9-1.3-1.3-1.3-1.4-1.4-1.5-1.31.1-1.0-1.0-1.0-0.8-0.5
Light reinforcement 11.43.46.7-0.81.41.41.41.71.71.61.82.0-2.12.12.12.32.6
Light reinforcement 23.75.77.81.12.72.72.72.82.82.72.80.5-0.72.62.62.62.2
Bone: marrow area0.30.81.0-0.6-1.0-1.0-1.0-1.0-1.0-1.0-1.0-0.00.1-0.9-0.9-0.9-0.8
Bone: maximum diameter0.20.31.60.2-0.3-0.3-0.3-0.4-0.4-0.4-0.4-0.70.7-0.5-0.5-0.8-1.3
Bone: maximum force0.91.52.5-0.6-1.3-1.3-1.3-1.4-1.3-1.4-1.3-0.30.4-1.3-1.3-1.4-1.6
Bone: maximum moment1.42.53.6-1.2-1.7-1.7-1.7-1.8-1.8-1.9-1.7-0.00.1-1.7-1.6-1.7-1.8
Mean time between licks in bursts0.41.03.8-1.9-0.3-0.3-0.30.00.0-0.10.01.9-1.80.40.40.91.3
Mean num. licks in bursts0.10.10.3-0.30.20.20.20.30.30.20.30.6-0.60.40.40.40.4
Cd content in liver1.61.72.5-0.1-1.3-1.3-1.4-1.4-1.4-1.4-1.4-0.80.9-1.5-1.5-1.6-1.5
Co content in liver1.51.87.02.60.50.50.40.20.20.30.0-2.62.6-0.4-0.5-0.9-1.5
Cu content in liver0.10.20.60.80.20.20.10.10.20.20.1-0.70.7-0.0-0.0-0.2-0.5
Fe content in liver0.40.52.1-1.20.10.10.20.30.30.20.41.4-1.40.60.60.70.5
K content in liver0.90.81.3-0.20.70.70.80.91.01.01.00.9-1.01.11.11.10.9
Mg content in liver1.31.32.6-0.90.70.70.90.90.90.91.01.6-1.61.21.21.41.4
Mn content in liver0.70.83.1-1.4-0.0-0.0-0.10.20.20.20.31.8-1.70.60.70.80.9
Na content in liver4.85.17.8-1.0-2.8-2.8-2.8-2.6-2.5-2.4-2.6-0.40.6-2.4-2.4-2.4-2.1
Rb content in liver0.70.81.30.71.11.11.11.01.11.01.0-0.10.00.90.90.80.4
Se content in liver3.74.48.1-2.9-2.6-2.6-2.6-2.3-2.3-2.3-2.21.8-1.6-1.7-1.6-1.2-0.5
Sr content in liver0.20.20.3-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.40.3-0.3-0.3-0.3-0.4-0.5
Zn content in liver0.70.81.4-1.2-1.1-1.1-1.0-1.0-1.0-1.0-0.90.7-0.6-0.7-0.7-0.6-0.5
Bone: minimum diameter1.22.33.2-1.1-1.7-1.7-1.7-1.7-1.7-1.8-1.7-0.00.1-1.6-1.6-1.6-1.6
Time in familiar zone, hab. session 10.20.20.40.60.60.60.60.50.50.50.5-0.30.30.40.40.3-0.1
Time in novel zone, hab. session 10.50.51.91.40.40.40.40.30.30.40.2-1.31.30.0-0.0-0.2-0.4
Total zone transitions, hab. session 10.91.21.8-0.7-1.3-1.3-1.3-1.3-1.3-1.3-1.3-0.10.2-1.2-1.2-1.1-0.8
Total locomotion distance, hab. session 11.31.82.6-1.5-1.6-1.6-1.6-1.6-1.5-1.6-1.50.6-0.4-1.3-1.3-1.1-0.8
Locomotion velocity, hab. session 12.53.65.3-2.3-2.3-2.3-2.3-2.2-2.2-2.2-2.11.0-0.9-1.8-1.7-1.4-0.8
Time in familiar zone, hab. session 21.81.95.22.31.51.51.51.31.31.31.2-1.81.70.80.70.4-0.4
Time in novel zone, hab. session 20.70.81.9-1.4-1.0-1.0-1.0-0.9-0.9-0.8-0.81.1-1.0-0.5-0.5-0.30.1
Total zone transitions, hab. session 23.14.05.7-0.7-2.2-2.2-2.1-2.3-2.4-2.3-2.4-0.81.0-2.4-2.4-2.2-1.4
Total locomotion distance, hab. session 21.41.82.7-0.9-1.6-1.6-1.4-1.6-1.6-1.6-1.6-0.10.3-1.6-1.5-1.3-0.8
Locomotion velocity, hab. session 22.33.14.4-0.9-2.0-2.0-1.9-2.1-2.1-2.1-2.1-0.40.5-2.0-2.0-1.8-1.2
Novel to familiar place preference ratio0.50.62.2-1.5-0.5-0.5-0.6-0.4-0.4-0.4-0.31.4-1.4-0.0-0.00.20.6
Novelty place preference0.40.51.8-1.3-0.5-0.5-0.5-0.4-0.4-0.4-0.31.3-1.2-0.1-0.10.20.5
Time in novel zone, NPP test0.30.31.1-1.1-0.5-0.5-0.5-0.4-0.4-0.4-0.40.9-0.9-0.2-0.20.00.4
Total zone transitions, NPP test1.11.63.0-1.7-1.5-1.5-1.3-1.4-1.5-1.5-1.40.9-0.8-1.1-1.1-0.8-0.1
Total locomotion distance, NPP test1.72.38.7-3.0-1.4-1.4-1.3-1.2-1.2-1.4-1.12.4-2.3-0.6-0.6-0.00.7
Locomotion velocity, NPP test1.52.28.4-2.9-1.3-1.3-1.2-1.1-1.2-1.3-1.02.4-2.2-0.5-0.5-0.00.7
Intraocular pressure0.20.31.0-0.9-0.2-0.2-0.1-0.0-0.0-0.1-0.01.0-1.00.20.20.51.0
Delta distance traveled before/after self-admin2.52.78.22.91.81.81.61.51.51.51.4-2.32.10.80.80.4-0.0
Delta ambulatory time before/after self-admin1.72.17.42.71.51.51.31.21.21.21.0-2.32.20.50.50.1-0.3
Parametrial fat weight0.61.34.2-1.50.50.50.50.60.60.50.72.0-2.01.11.11.31.3
Pavlov. Cond. lever latency0.60.71.10.91.01.01.01.01.01.11.0-0.30.30.80.80.70.4
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.1-0.10.0-0.0-0.0-0.1-0.00.2-0.20.00.00.10.1
Pavlov. Cond. change in total contacts1.61.72.3-0.3-1.4-1.4-1.3-1.4-1.4-1.5-1.5-0.70.8-1.5-1.5-1.4-1.1
Pavlov. Cond. index score0.40.60.9-0.5-0.9-0.9-0.8-0.9-0.9-0.9-0.90.00.1-0.8-0.8-0.7-0.5
Pavlov. Cond. latency score0.50.60.9-0.7-0.9-0.9-0.9-0.9-0.9-1.0-0.90.1-0.1-0.8-0.8-0.7-0.5
Pavlov. Cond. lever contacts0.40.50.9-0.9-0.9-0.9-0.9-0.8-0.8-0.9-0.80.4-0.4-0.6-0.6-0.5-0.2
Pavlov. Cond. magazine entry number0.20.30.4-0.20.50.50.30.50.50.50.50.6-0.60.60.60.60.5
Pavlov. Cond. intertrial magazine entries1.11.32.1-1.4-1.4-1.4-1.5-1.3-1.3-1.3-1.30.7-0.6-1.1-1.0-0.9-0.5
Pavlov. Cond. lever-magazine prob. diff.0.50.61.0-0.4-0.9-0.9-0.8-0.9-0.9-1.0-0.9-0.20.2-0.9-0.9-0.8-0.6
Pavlov. Cond. response bias0.20.20.3-0.1-0.5-0.5-0.4-0.5-0.5-0.5-0.5-0.30.3-0.5-0.5-0.5-0.3
Pavlov. Cond. lever latency2.53.55.11.22.32.32.32.12.22.12.20.2-0.42.02.01.81.2
Pavlov. Cond. magazine entry latency0.91.11.8-1.3-1.3-1.3-1.3-1.2-1.2-1.2-1.20.6-0.5-1.0-1.0-0.7-0.2
Pavlov. Cond. change in total contacts1.72.73.6-0.2-1.8-1.8-1.8-1.8-1.8-1.7-1.8-1.01.1-1.9-1.9-1.9-1.4
Pavlov. Cond. index score2.43.24.7-1.1-2.2-2.2-2.2-2.1-2.1-2.0-2.1-0.30.4-2.0-2.0-1.8-1.1
Pavlov. Cond. latency score2.43.14.7-1.2-2.2-2.2-2.2-2.1-2.1-2.0-2.1-0.10.3-1.9-1.9-1.7-1.0
Pavlov. Cond. lever contacts2.43.34.9-1.4-2.2-2.2-2.2-2.1-2.1-2.1-2.10.00.1-2.0-2.0-1.7-1.0
Pavlov. Cond. magazine entry number0.50.71.10.91.01.01.00.91.00.90.9-0.40.30.80.80.60.0
Pavlov. Cond. intertrial magazine entries1.72.57.9-1.90.60.60.60.80.80.70.92.8-2.81.41.41.82.1
Pavlov. Cond. lever-magazine prob. diff.2.12.84.1-0.9-2.0-2.0-2.0-1.9-1.9-1.9-1.9-0.40.5-1.9-1.9-1.7-1.0
Pavlov. Cond. response bias2.63.65.4-1.4-2.3-2.3-2.3-2.2-2.2-2.2-2.2-0.00.2-2.0-2.0-1.8-1.1
Time in closed arm before self-admin0.50.72.61.60.60.60.50.40.40.50.3-1.61.5-0.0-0.0-0.3-0.6
Time in closed arm after self-admin0.00.00.00.10.10.10.00.10.10.00.0-0.10.1-0.0-0.0-0.0-0.1
Time in open arm before self-admin0.30.30.5-0.4-0.7-0.7-0.6-0.7-0.7-0.7-0.70.1-0.1-0.6-0.6-0.5-0.2
Time in open arm after self-admin0.10.10.3-0.4-0.5-0.5-0.4-0.4-0.5-0.4-0.40.3-0.2-0.3-0.3-0.3-0.1
Bone: periosteal estimation0.51.01.5-0.8-1.1-1.1-1.1-1.1-1.1-1.2-1.10.00.0-1.0-1.0-1.1-1.2
Bone: periosteal perimeter0.40.81.0-0.6-1.0-1.0-1.0-1.0-1.0-1.0-0.90.00.1-0.9-0.9-0.9-0.9
Bone: post-yield work0.60.81.30.31.11.11.11.11.01.01.10.3-0.31.01.00.90.7
Progressive ratio test 1 active lever presses0.81.01.71.11.21.21.31.11.11.11.1-0.60.50.90.90.80.5
Progressive ratio test 1 breakpoint0.91.01.71.31.21.21.31.11.11.11.1-0.70.60.90.90.70.5
Progressive ratio test 1 inactive lever presses0.71.11.6-0.20.90.91.01.11.11.01.10.9-1.01.21.21.31.3
Progressive ratio test 2 active lever presses0.50.60.90.60.90.91.00.90.90.90.9-0.0-0.00.80.80.80.6
Progressive ratio test 2 breakpoint0.30.30.50.40.70.70.70.60.60.60.6-0.0-0.00.60.60.60.5
Progressive ratio test 2 inactive lever presses0.10.20.4-0.30.40.40.40.40.40.40.40.6-0.60.50.50.60.6
Incentive Sensitization - Responses0.10.10.3-0.40.10.10.00.10.10.10.10.6-0.60.20.20.30.3
Incentive Sensitization - Breakpoint0.10.10.5-0.6-0.1-0.1-0.1-0.0-0.0-0.0-0.00.7-0.70.20.20.30.3
Sum of active levers in priming session hrs 5-60.70.70.90.60.90.91.00.90.91.00.90.0-0.10.90.90.80.9
Progressive ratio0.10.20.70.80.50.50.50.40.30.50.3-0.30.30.30.30.40.3
Food seeking constrained by brief footshock4.65.611.83.42.92.92.72.52.52.52.4-2.42.21.71.71.20.5
Seeking ratio, punishment vs. effort0.60.91.81.31.11.10.91.01.00.91.0-1.21.20.50.50.2-0.2
Retroperitoneal fat weight0.20.71.20.11.11.11.00.90.90.81.00.4-0.50.90.90.80.3
Reaction time number correct0.20.51.71.30.60.60.60.40.40.50.4-1.21.20.10.10.0-0.1
Reaction time mean minus median0.40.91.3-0.6-1.0-1.0-1.1-1.1-1.1-1.1-1.1-0.10.2-1.1-1.1-1.0-0.8
Reaction time mean minus median AUC0.10.30.4-0.3-0.6-0.6-0.6-0.6-0.7-0.6-0.7-0.20.2-0.6-0.6-0.6-0.3
Reaction time num false alarms0.20.30.5-0.2-0.6-0.6-0.6-0.7-0.7-0.7-0.7-0.30.3-0.7-0.7-0.5-0.0
Reaction time num false alarms AUC0.10.20.4-0.3-0.5-0.5-0.5-0.6-0.6-0.6-0.6-0.20.2-0.6-0.6-0.40.2
Reaction time trials correct on left0.20.51.71.30.60.60.60.40.40.50.4-1.21.20.10.10.0-0.1
Reaction time trials on left0.20.41.51.20.60.60.60.50.50.50.4-1.11.00.20.20.10.0
Reaction time mean0.20.30.5-0.2-0.6-0.6-0.6-0.6-0.7-0.7-0.7-0.30.3-0.7-0.7-0.6-0.3
Reaction time mean AUC0.40.60.9-0.2-0.8-0.8-0.7-0.9-0.9-0.9-0.9-0.50.5-0.9-0.9-0.9-0.6
Median of all reaction times0.10.10.10.0-0.2-0.2-0.2-0.3-0.3-0.4-0.3-0.30.4-0.4-0.4-0.3-0.1
Reaction time omissions0.71.12.5-1.20.60.60.60.70.70.60.81.6-1.61.01.01.21.5
Reaction time false alarm rate0.10.10.4-0.6-0.4-0.4-0.3-0.4-0.4-0.4-0.40.4-0.3-0.3-0.3-0.10.3
Reaction time premature initiation rate0.81.14.62.10.80.80.70.60.60.70.5-1.91.90.10.1-0.1-0.0
Reaction time premature initiations1.11.97.52.71.11.11.11.00.91.10.8-2.42.30.30.30.10.1
Std. dev. reaction times0.30.50.8-0.4-0.7-0.7-0.8-0.9-0.9-0.9-0.9-0.20.3-0.9-0.9-0.8-0.4
Reaction time trials completed0.20.41.51.20.60.60.60.50.50.50.4-1.11.00.20.20.10.0
Reaction time trials AUC0.20.41.31.20.60.60.60.50.50.50.4-1.01.00.20.20.10.0
Run reversals in cocaine runway, females0.90.93.2-1.10.20.20.30.40.30.30.41.8-1.80.80.81.11.3
Run reversals in cocaine runway, males0.80.81.70.7-0.5-0.5-0.6-0.7-0.6-0.7-0.7-1.31.3-1.0-1.0-1.1-1.3
Latency to leave start box in cocaine runway0.20.20.50.2-0.1-0.1-0.1-0.3-0.3-0.3-0.3-0.70.7-0.5-0.5-0.6-0.6
Latency to leave start box in cocaine runway, F0.60.71.50.5-0.4-0.4-0.5-0.7-0.6-0.6-0.7-1.21.2-0.9-0.9-1.0-1.1
Latency to leave start box in cocaine runway, M0.00.00.2-0.4-0.0-0.0-0.0-0.0-0.1-0.10.00.3-0.30.00.00.10.2
Std. dev. time between licks in bursts2.43.28.5-2.9-2.1-2.1-2.1-1.8-1.8-1.9-1.71.9-1.8-1.2-1.2-0.60.4
Total sessions with >9 infusions0.00.00.10.20.20.20.30.10.10.10.1-0.20.20.10.10.0-0.0
Short access day 1 total inactive lever presses0.30.50.8-0.8-0.9-0.9-0.9-0.8-0.7-0.7-0.70.6-0.5-0.5-0.5-0.4-0.2
Short access day 10 total inactive lever presses0.00.10.3-0.10.20.20.20.30.30.40.30.4-0.40.40.40.40.5
Short access day 1 total infusions0.30.30.60.60.80.80.80.70.70.60.7-0.40.30.50.50.40.2
Short access day 10 total infusions0.70.91.3-0.3-1.0-1.0-0.9-1.1-1.1-1.2-1.1-0.30.4-1.1-1.1-1.0-1.0
Short access total infusions0.00.00.1-0.1-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.10.1-0.3-0.3-0.3-0.3
Short access day 1 locomotion1.21.52.1-0.1-1.3-1.3-1.2-1.3-1.3-1.4-1.4-0.70.8-1.4-1.4-1.5-1.3
Short access day 10 total locomotion0.20.40.8-0.6-0.8-0.8-0.9-0.8-0.8-0.7-0.80.1-0.1-0.7-0.7-0.6-0.4
Short access total locomotion1.21.52.1-0.7-1.4-1.4-1.4-1.4-1.4-1.4-1.4-0.00.1-1.3-1.3-1.2-1.0
One hour access (0.3 mA shock)0.30.41.3-1.1-0.7-0.7-0.6-0.5-0.4-0.4-0.41.0-1.0-0.1-0.10.00.2
Compulsive drug intake0.80.92.5-1.6-1.1-1.1-1.0-1.0-1.0-1.0-0.91.1-1.0-0.6-0.6-0.5-0.1
One hour access (shock baseline)0.00.00.1-0.1-0.3-0.3-0.3-0.2-0.2-0.1-0.20.1-0.1-0.1-0.1-0.1-0.1
Social response proportion2.83.25.02.02.22.22.22.12.12.02.0-0.80.61.71.71.30.3
Social responses0.81.01.5-0.40.90.90.91.01.11.01.11.1-1.11.21.21.10.6
Social time0.91.22.5-1.6-1.3-1.3-1.3-1.2-1.2-1.2-1.11.0-0.9-0.8-0.8-0.7-0.4
Soleus weight0.31.04.41.80.20.20.3-0.0-0.10.0-0.2-2.12.1-0.6-0.6-0.7-0.6
Bone: stiffness0.40.71.80.4-0.6-0.6-0.6-0.8-0.8-0.8-0.8-0.90.9-0.9-0.9-1.1-1.4
Tibialis anterior weight3.411.526.93.0-2.0-2.0-2.0-2.6-2.6-2.3-2.8-5.15.2-3.6-3.6-4.2-4.2
Time to tail flick, vehicle, before self-admin0.60.61.0-0.40.60.60.60.70.70.60.70.9-1.00.90.91.01.0
Time to tail flick, vehicle, after self-admin1.52.05.22.31.61.61.71.41.41.41.3-1.81.60.80.80.50.1
Time to tail flick, test, before self-admin0.80.83.6-1.7-0.4-0.4-0.3-0.2-0.3-0.3-0.11.9-1.90.30.30.60.9
Time to tail flick, test, after self-admin4.14.25.70.22.22.22.22.32.32.12.31.2-1.32.32.32.42.1
Delta time to tail flick, vehicle, before/after SA1.11.11.81.41.31.31.31.11.11.11.1-0.90.80.80.80.70.4
Delta time to tail flick, test, before/after SA4.34.46.61.62.62.62.52.52.52.42.4-0.50.32.12.12.01.4
Tibia length2.56.917.7-4.2-3.0-3.0-3.0-2.7-2.7-2.9-2.52.8-2.6-1.8-1.8-1.4-1.0
Ambulatory time before self-admin1.11.72.4-0.6-1.5-1.5-1.5-1.5-1.5-1.4-1.5-0.20.3-1.4-1.4-1.4-1.2
Ambulatory time after self-admin1.72.16.31.8-0.6-0.6-0.6-0.8-0.8-0.7-0.9-2.52.5-1.3-1.3-1.6-1.8
Bone: tissue strength0.20.20.5-0.7-0.3-0.3-0.4-0.4-0.4-0.5-0.30.4-0.3-0.3-0.3-0.4-0.5
Total heroin consumption0.60.71.00.1-0.9-0.9-0.8-0.9-0.9-0.9-0.9-0.60.7-1.0-1.0-1.0-0.9
Bone: trabecular number0.61.03.8-1.50.10.10.10.30.30.20.41.9-1.90.70.81.01.2
Bone: trabecular spacing0.70.93.21.3-0.2-0.2-0.3-0.4-0.4-0.3-0.5-1.81.8-0.8-0.8-1.1-1.3
Bone: trabecular thickness0.40.51.9-1.4-0.4-0.4-0.4-0.2-0.2-0.3-0.21.4-1.30.10.10.40.6
Bone: trabecular tissue density0.91.32.00.5-1.0-1.0-1.0-1.1-1.1-1.0-1.1-1.21.3-1.3-1.3-1.4-1.4
Water consumed over 24 hours0.81.11.60.4-0.9-0.9-0.9-1.0-1.0-0.9-1.0-1.11.2-1.2-1.2-1.3-1.2
Number of responses in last shaping day0.30.30.50.4-0.4-0.4-0.3-0.4-0.4-0.5-0.5-0.70.7-0.6-0.6-0.7-0.7