Hub : Genes

Xpnpep3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Xpnpep3 0.36 0.14 7.5e-06 0.18 0.12 0.1 0.11 5.7e-05 8.7e-04 2.5e-03 1.2e-03
2 pVTA gene expression Xpnpep3 0.07 0.04 1.9e-06 0.08 0.07 0.07 0.07 4.4e-07 4.6e-06 4.2e-06 3.0e-06
3 BLA gene expression Xpnpep3 0.15 0.07 2.8e-09 0.13 0.16 0.15 0.14 1.9e-07 1.0e-08 3.3e-08 5.2e-08
4 Adipose mRNA stability Xpnpep3 0.11 0.06 1.7e-13 0.1 0.09 0.09 0.1 2.0e-11 1.8e-10 3.4e-10 6.9e-11
5 PL gene expression Xpnpep3 0.2 0.09 0.0e+00 0.17 0.17 0.16 0.18 4.9e-18 4.3e-18 1.3e-17 4.5e-19
6 NAcc gene expression Xpnpep3 0.08 0.04 2.6e-14 0.1 0.09 0.09 0.1 1.8e-14 5.1e-13 7.8e-14 2.4e-14
7 Brain isoform ratio XM_039079904.2 0.03 0.02 5.5e-03 0.02 0.02 0.02 0.02 2.6e-03 3.0e-03 2.8e-03 3.8e-03
8 IC gene expression Xpnpep3 0.28 0.13 1.9e-10 0.2 0.2 0.22 0.21 9.2e-09 1.0e-08 1.3e-09 2.9e-09
9 Adipose gene expression Xpnpep3 0.02 0.02 5.3e-03 0.03 0.01 0.02 0.02 2.5e-04 2.4e-02 2.3e-03 1.6e-03
10 LHb gene expression Xpnpep3 0.82 0.09 2.9e-04 0 0.05 0.04 0.01 2.8e-01 2.6e-02 3.3e-02 1.6e-01
11 NAcc alternative TSS XM_063264263.1 0.03 0.02 5.8e-03 0.01 0.01 0.01 0.01 2.5e-02 2.9e-03 3.3e-03 8.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.10.20.5-0.4-0.4-0.3-0.4-0.5-0.70.7-0.40.60.40.4
Area under the delay curve1.01.15.3-0.9-0.9-0.7-1.0-0.6-0.50.4-0.51.1-2.3-1.4
BMI with tail1.03.65.82.22.22.22.42.11.7-1.61.80.62.30.5
BMI without tail0.20.53.20.30.30.40.50.1-0.20.30.60.11.81.0
Body weight1.35.58.82.62.62.83.02.82.7-2.42.61.21.2-0.6
Weight adjusted by age0.20.31.4-0.6-0.7-0.3-0.10.20.30.20.1-1.20.6-0.4
Bone surface0.40.71.1-1.0-1.0-0.7-1.0-0.8-0.70.7-0.90.6-1.0-0.7
Bone volume0.10.10.4-0.3-0.3-0.1-0.3-0.2-0.30.3-0.60.6-0.3-0.1
Breakpoint value in progressive ratio session0.10.20.80.30.10.40.40.20.20.20.60.90.40.2
Number of licking bursts0.71.22.0-1.4-1.4-1.3-1.4-1.2-1.00.9-0.9-1.0-0.6-0.7
Context. condit. distance diff. score4.95.99.42.82.82.52.83.13.0-2.92.2-0.91.4-0.1
Locomotion velocity, session 11.01.15.7-0.9-0.9-0.5-0.9-0.5-0.20.1-0.70.6-2.4-1.7
Locomotion distance, session 13.94.910.1-2.6-2.6-2.3-2.6-2.2-1.81.7-2.30.1-3.2-1.4
Locomotion velocity, session 20.20.20.40.40.40.50.40.50.5-0.40.60.6-0.3-0.3
Locomotion distance, session 22.83.95.6-2.4-2.4-1.8-2.3-2.2-2.02.0-1.51.3-2.2-1.1
Locomotion velocity, session 30.20.22.00.00.0-0.2-0.00.20.4-0.4-0.2-1.40.2-0.1
Locomotion distance, session 32.12.33.5-1.7-1.7-1.9-1.8-1.4-1.00.9-1.8-1.8-1.3-0.5
Stereotopy head waving bouts, day 31.01.12.11.11.11.21.11.01.0-1.01.31.5-0.2-0.6
Stereotopy head waving duration, day 33.44.06.02.42.42.42.42.21.9-1.92.41.70.7-0.2
Locomotion velocity, session 70.10.10.40.30.30.30.20.50.5-0.60.2-0.4-0.2-0.4
Locomotion distance, session 70.30.42.6-0.2-0.2-0.1-0.3-0.10.1-0.2-0.30.6-1.6-1.0
Stereotopy head waving bouts, day 71.41.62.41.41.41.21.41.51.5-1.51.4-0.80.7-0.0
Stereotopy head waving duration, day 72.02.43.51.91.91.51.81.71.4-1.51.3-0.91.71.0
Locomotion velocity, session 81.31.52.81.01.01.41.21.51.5-1.31.70.9-0.2-1.3
Locomotion distance, session 80.40.61.00.80.80.80.91.01.0-0.90.6-0.60.60.1
Degree of sensitization distance3.53.65.62.32.32.42.32.11.7-1.62.11.90.80.2
Degree of sensitization stereotypy1.01.11.71.21.21.01.11.31.2-1.31.0-0.90.70.0
Conditioned locomotion0.30.40.70.80.80.70.70.80.7-0.80.6-0.1-0.2-0.0
Cocaine response after cond. corrected0.20.20.30.40.40.50.40.40.4-0.40.30.6-0.6-0.2
Cocaine response after cond. not corrected0.10.10.20.30.30.40.40.20.2-0.10.10.4-0.00.4
Cocaine response before conditioning0.40.51.2-0.4-0.4-0.5-0.3-0.6-0.60.7-0.6-0.71.11.1
Saline control response0.20.31.3-0.0-0.0-0.3-0.0-0.2-0.10.1-0.9-1.20.40.8
Bone: connectivity density0.00.10.4-0.1-0.1-0.0-0.1-0.1-0.20.2-0.00.60.2-0.1
Bone: cortical apparent density1.21.62.9-1.4-1.4-1.6-1.4-1.4-1.11.1-1.2-1.70.70.3
Bone: cortical area1.32.03.21.61.61.81.61.51.4-1.31.21.8-0.1-0.7
Bone: cortical porosity0.80.81.41.21.21.11.20.90.6-0.60.70.50.90.9
Bone: cortical porosity1.82.03.21.81.81.81.81.61.2-1.21.31.20.50.4
Bone: cortical thickness0.30.51.40.60.60.80.70.60.6-0.50.81.20.4-0.7
Bone: cortical thickness0.60.72.60.30.30.60.30.30.4-0.50.91.6-0.7-1.5
Bone: cortical tissue density1.11.52.8-1.3-1.3-1.5-1.3-1.3-1.11.0-1.1-1.70.70.2
Condit. Reinf. active minus inactive responses0.20.30.5-0.6-0.6-0.5-0.7-0.6-0.50.5-0.30.2-0.3-0.5
Condit. Reinf. active-inactive response ratio0.10.10.20.30.30.20.20.30.4-0.40.2-0.40.1-0.3
Condit. Reinf. active responses1.31.62.7-1.4-1.4-1.4-1.5-1.6-1.61.5-1.4-0.30.10.6
Condit. Reinf. inactive responses2.53.05.4-1.8-1.8-1.8-1.8-2.1-2.32.1-2.0-0.70.21.4
Incentive salience index mean0.50.60.9-0.9-0.9-0.8-0.9-0.9-0.80.8-0.80.1-0.2-0.3
Condit. Reinf. lever presses0.70.91.5-1.1-1.1-1.0-1.0-1.2-1.21.2-1.20.00.10.3
Condit. Reinf. active minus inactive responses0.60.83.3-0.4-0.4-0.2-0.7-0.3-0.1-0.10.11.3-1.8-1.8
Condit. Reinf. active-inactive response ratio0.50.62.30.10.10.4-0.00.20.3-0.41.01.5-0.9-1.5
Condit. Reinf. active responses0.60.83.60.10.10.3-0.10.30.6-0.70.41.1-1.6-1.9
Condit. Reinf. inactive responses0.50.62.00.40.40.40.30.60.9-0.90.30.5-1.4-1.4
Condit. Reinf. lever presses0.20.30.6-0.7-0.7-0.6-0.7-0.7-0.70.7-0.60.3-0.2-0.1
Condit. Reinf. lever reinforcers received0.40.52.40.10.10.2-0.10.10.3-0.50.31.1-1.4-1.5
Conditioned reinforcement - actives0.50.81.80.81.00.60.40.50.7-1.31.00.8-0.8-1.4
Conditioned reinforcement - inactives0.30.41.3-0.3-0.4-0.0-0.4-0.5-0.50.5-0.91.1-1.0-0.9
Conditioned locomotion1.82.34.41.92.11.71.61.31.3-1.71.51.50.2-0.9
Patch foraging indifference point 0 sec0.30.51.1-0.6-0.6-0.5-0.4-0.8-0.91.1-0.40.41.00.7
Patch foraging indifference point AUC1.42.07.3-1.6-1.6-1.2-1.6-0.9-0.60.5-0.90.2-2.7-2.0
Delay disc. indifference point, 0s delay0.91.02.01.41.41.41.21.00.8-0.80.50.9-0.10.5
Delay disc. indifference point, 16s delay1.51.74.1-1.5-1.5-1.3-1.5-1.1-1.11.0-1.10.6-2.0-1.0
Delay disc. indifference point, 2s delay0.50.53.3-0.2-0.2-0.0-0.3-0.2-0.0-0.2-0.01.1-1.8-1.1
Delay disc. indifference point, 24s delay1.82.09.3-1.3-1.3-0.7-1.0-0.3-0.10.1-0.30.8-3.1-2.7
Delay disc. indifference point, 4s delay0.40.51.6-0.5-0.5-0.3-0.6-0.4-0.40.20.01.1-1.3-1.0
Delay disc. indifference point, 8s delay1.11.34.0-1.2-1.2-1.0-1.3-1.0-0.90.7-0.70.9-2.0-1.0
Indifference point function ln k1.22.16.21.71.71.21.61.21.0-1.11.3-0.72.51.2
Indifference point function log k1.22.16.21.71.71.21.61.21.0-1.11.3-0.72.51.2
Patch foraging total patch changes 0 sec0.30.61.4-0.7-0.7-0.6-0.5-1.0-1.01.2-0.60.40.80.8
Patch foraging total patch changes 12 sec0.10.20.5-0.4-0.4-0.1-0.3-0.2-0.10.2-0.20.6-0.7-0.5
Patch foraging total patch changes 18 sec0.40.62.7-0.6-0.6-0.1-0.6-0.5-0.60.6-0.31.6-1.4-0.7
Patch foraging total patch changes 24 sec0.40.72.0-0.9-0.9-0.8-0.9-0.8-0.70.7-1.00.4-1.4-0.4
Patch foraging total patch changes 6 sec0.71.13.2-1.1-1.1-0.5-0.9-0.9-0.81.0-0.61.8-1.3-1.0
Patch foraging time to switch 0 sec0.20.42.30.70.70.60.70.3-0.10.1-0.20.50.41.5
Patch foraging water rate 0 sec0.10.20.2-0.5-0.5-0.3-0.4-0.4-0.50.5-0.10.30.4-0.3
Patch foraging water rate 12 sec0.40.81.2-0.7-0.7-0.9-0.8-1.0-1.11.0-1.0-0.80.60.8
Patch foraging water rate 18 sec0.71.11.9-1.4-1.4-1.1-1.1-1.2-1.21.4-1.20.1-0.10.0
Patch foraging water rate 24 sec0.20.31.60.40.40.40.60.30.2-0.20.4-0.01.30.3
Patch foraging water rate 6 sec1.31.93.0-1.5-1.5-1.7-1.5-1.5-1.51.3-1.5-1.70.80.6
Seeking ratio, delayed vs. immediate footshock1.92.33.8-1.6-1.6-1.5-1.6-1.6-1.61.7-1.9-1.60.50.6
Distance traveled before self-admin0.20.31.1-0.7-0.6-0.1-0.1-0.4-0.41.1-0.10.40.30.5
Distance traveled after self-admin0.30.32.3-0.6-0.10.0-0.3-0.5-0.50.40.31.5-0.3-0.5
Extensor digitorum longus weight0.20.72.3-0.3-0.3-0.6-0.3-0.7-0.90.9-1.2-0.61.21.5
Bone: elastic displacement0.00.00.00.10.10.1-0.10.20.1-0.2-0.1-0.1-0.1-0.2
Bone: elastic work2.22.94.92.02.02.21.92.01.7-1.61.61.80.1-0.4
Bone: endosteal estimation0.51.11.91.11.11.31.01.00.8-0.90.31.4-1.3-0.0
Bone: endosteal perimeter1.02.23.61.91.91.81.61.71.5-1.61.11.1-0.5-0.1
Epididymis fat weight2.48.212.43.53.53.33.43.53.2-3.22.80.90.7-0.2
Delta time in closed arm before/after self-admin0.40.41.2-0.3-0.20.40.30.60.6-0.21.00.6-0.4-1.1
Delta time in open arm before/after self-admin0.50.52.00.20.4-0.6-0.7-0.8-0.7-0.2-1.4-0.4-1.10.5
Diff in mean of infusions in LGA sessions0.50.62.2-0.5-0.50.50.30.60.80.01.11.1-0.6-1.5
Delay discount exponential model param1.11.35.61.01.00.81.10.70.6-0.40.6-1.02.41.4
Extinction: sum of active levers before priming1.21.31.91.11.01.31.01.21.1-1.01.41.4-1.2-0.9
Active lever presses in extinction session 60.30.30.50.70.60.70.60.60.5-0.60.4-0.50.20.1
Bone: final force1.72.65.61.51.52.01.61.71.6-1.51.62.4-0.6-1.3
Bone: final moment1.82.86.41.61.62.01.71.81.6-1.51.62.5-0.7-1.4
Food consumed during 24 hour testing period1.62.23.61.51.51.81.61.61.6-1.51.91.4-0.3-1.1
Glucose0.20.41.90.20.20.30.4-0.0-0.30.4-0.20.31.41.2
Heart weight4.77.311.83.43.43.43.23.02.6-2.72.52.31.0-0.4
Delay discount hyperbolic model param1.01.15.10.90.90.71.00.70.6-0.30.5-1.02.31.4
Intermittent access intake day 1-15 change0.20.41.5-0.4-0.4-0.5-0.4-0.5-0.80.6-0.20.01.21.0
Intermittent access intake escalation0.30.61.0-0.8-0.7-0.8-0.7-0.7-1.00.8-0.30.10.90.8
Intermittent access intake escalation 20.40.51.6-0.6-0.5-0.6-0.4-0.5-0.90.8-0.6-0.20.91.3
Intermitt. access day 1 inactive lever presses0.20.91.71.31.11.11.00.70.5-0.60.71.11.10.2
Intermitt. access day 15 inactive lever presses0.10.20.7-0.3-0.30.1-0.1-0.3-0.40.6-0.30.50.9-0.1
Intermitt. access escalation Index0.50.71.9-1.3-1.4-0.7-0.6-0.6-0.61.3-0.4-0.21.00.1
Intermittent access day 1 total infusions0.50.82.40.20.31.00.60.60.8-0.30.61.1-1.5-1.4
Intermittent access day 15 total infusions0.20.30.8-0.6-0.6-0.5-0.6-0.6-0.60.6-0.40.6-0.9-0.2
Intermittent access terminal intake (last 3 days)0.10.10.6-0.3-0.2-0.1-0.2-0.1-0.20.3-0.20.1-0.8-0.1
Intermittent access total infusions0.40.52.70.10.10.60.30.30.4-0.00.20.9-1.6-0.8
Intermittent access day 1 locomotion0.20.31.60.60.70.70.50.10.2-0.10.11.3-0.3-0.1
Intermittent access day 15 total locomotion0.30.50.90.80.80.90.70.50.5-0.50.41.0-0.7-0.3
Intermittent access total locomotion0.70.82.10.90.91.10.90.70.7-0.60.51.5-1.2-0.5
Intermittent access standard deviation0.61.32.41.41.21.51.51.10.6-0.41.21.20.71.0
Left kidney weight7.635.548.86.86.87.06.87.06.9-6.86.43.11.0-2.8
Right kidney weight9.844.661.77.77.77.97.87.87.6-7.47.33.61.6-2.7
Cocaine induced anxiety1.62.34.21.41.31.82.02.02.0-1.31.71.10.1-0.9
Post-drug Anxiety0.10.10.40.0-0.10.20.40.50.6-0.10.70.10.2-0.4
Baseline Anxiety2.93.46.1-1.9-1.9-2.4-2.5-2.3-2.21.6-1.8-1.1-0.90.4
Tail length0.41.52.3-1.5-1.5-1.4-1.3-1.3-1.41.5-1.0-0.9-0.20.8
Length with tail0.10.61.30.70.70.80.91.11.1-0.90.90.1-0.2-0.6
Length without tail2.06.59.32.92.93.03.03.03.0-2.92.51.7-0.1-1.2
Times rat made contact with spout0.40.52.60.20.20.40.20.50.7-0.70.60.1-0.9-1.6
Lifetime Intake0.81.02.30.40.51.20.80.80.8-0.40.81.4-1.5-1.4
Liver weight, left0.50.81.70.80.80.60.81.11.3-1.30.6-1.2-0.4-0.3
Liver weight, right1.93.44.62.02.01.52.02.12.1-2.01.1-2.11.80.8
Locomotor activity1.52.43.92.02.01.81.61.91.6-1.81.60.60.3-0.2
Locomotor testing distance0.00.10.2-0.2-0.2-0.3-0.4-0.3-0.40.2-0.1-0.10.10.2
Locomotor testing rearing0.71.52.21.51.51.41.41.51.4-1.41.20.20.4-0.2
Locomotion in novel chamber1.41.82.8-0.2-0.0-1.6-1.5-1.7-1.60.6-1.6-1.71.11.5
Locomotion in novel chamber post-restriction0.40.71.2-0.8-0.7-1.1-1.0-0.9-1.10.8-1.0-0.40.10.9
Fecal boli incidents, locomotor time 10.30.52.3-0.4-0.4-0.2-0.5-0.3-0.40.3-0.31.2-1.5-0.7
Change in fecal boli incidents, locomotor task0.60.63.00.00.00.00.10.50.9-1.01.1-0.4-0.6-1.7
Time >=10cm from walls, locomotor time 10.50.50.80.70.70.90.90.80.9-0.60.90.5-0.1-0.3
Bouts of movement, locomotor time 10.91.01.90.80.80.91.11.21.4-1.20.6-0.7-1.2-1.0
Total resting periods, locomotor time 10.60.71.40.60.60.90.91.01.2-0.90.6-0.4-0.9-0.9
Rest time, locomotor task time 10.81.11.91.11.11.11.01.01.0-1.11.11.4-0.4-0.8
Distance moved, locomotor task time 10.20.31.00.50.50.30.50.50.3-0.30.3-0.41.00.8
Vertical activity count, locomotor time 10.00.10.40.00.0-0.0-0.0-0.0-0.20.2-0.1-0.00.40.6
Time >=10cm from walls, locomotor time 20.00.00.1-0.3-0.3-0.1-0.1-0.2-0.30.40.0-0.10.30.0
Bouts of movement, locomotor time 20.30.41.00.70.70.60.80.60.7-0.7-0.0-0.51.0-0.0
Total resting periods, locomotor time 20.10.30.40.60.60.60.60.50.6-0.60.1-0.10.5-0.4
Rest time, locomotor task time 20.30.31.3-0.4-0.4-0.3-0.3-0.2-0.00.10.21.2-0.9-0.9
Distance moved, locomotor task time 20.40.40.90.90.90.60.70.60.4-0.60.4-0.30.90.7
Vertical activity count, locomotor time 20.10.20.60.50.50.50.40.30.2-0.30.40.8-0.00.4
Light reinforcement 10.00.10.2-0.1-0.1-0.1-0.3-0.2-0.30.1-0.30.3-0.4-0.2
Light reinforcement 20.71.12.01.11.10.91.21.11.0-0.91.1-0.81.40.6
Bone: marrow area0.51.22.21.21.21.31.01.10.9-1.00.41.5-1.4-0.1
Bone: maximum diameter3.15.88.82.72.73.02.72.72.6-2.52.42.5-0.2-1.2
Bone: maximum force2.44.29.41.91.92.51.92.11.9-1.92.03.1-1.0-1.6
Bone: maximum moment2.64.610.12.02.02.62.02.22.0-2.02.13.2-1.0-1.8
Mean time between licks in bursts0.30.71.1-0.6-0.6-0.7-0.6-0.8-1.00.9-0.7-1.00.91.1
Mean num. licks in bursts1.21.92.91.61.61.61.51.71.7-1.71.40.7-0.1-0.6
Cd content in liver0.80.93.90.40.40.50.30.91.1-1.21.10.5-0.9-2.0
Co content in liver0.10.11.3-0.3-0.30.1-0.2-0.1-0.00.10.30.2-0.2-1.1
Cu content in liver5.16.09.2-2.8-2.8-2.6-2.7-3.0-3.03.0-2.7-0.2-0.51.0
Fe content in liver0.91.12.11.31.31.41.41.00.8-0.61.11.20.50.4
K content in liver1.31.21.8-1.3-1.3-1.3-1.2-1.3-1.21.3-1.2-0.90.20.3
Mg content in liver0.90.91.6-1.2-1.2-1.0-1.0-1.1-1.11.3-1.00.10.10.2
Mn content in liver0.10.10.2-0.4-0.4-0.5-0.4-0.2-0.00.1-0.4-0.5-0.2-0.3
Na content in liver1.61.72.8-1.3-1.3-1.3-1.3-1.6-1.71.7-1.5-0.30.21.1
Rb content in liver0.30.42.1-0.1-0.10.3-0.10.10.2-0.20.10.6-1.2-1.4
Se content in liver0.40.50.8-0.8-0.8-0.9-0.7-0.7-0.60.7-0.6-0.20.60.6
Sr content in liver2.11.82.7-1.6-1.6-1.6-1.6-1.4-1.61.6-1.1-0.40.60.9
Zn content in liver0.20.20.5-0.6-0.6-0.4-0.4-0.4-0.10.3-0.7-0.0-0.3-0.5
Bone: minimum diameter0.40.81.81.01.01.10.80.80.6-0.80.51.4-1.0-0.2
Time in familiar zone, hab. session 10.70.73.1-0.3-0.30.0-0.20.10.5-0.4-0.00.9-1.8-1.7
Time in novel zone, hab. session 11.41.44.41.21.20.91.10.80.3-0.30.9-0.52.11.9
Total zone transitions, hab. session 15.07.011.0-3.2-3.2-3.2-3.3-2.9-2.52.2-3.1-1.8-1.8-0.5
Total locomotion distance, hab. session 13.14.36.9-2.3-2.3-2.5-2.5-2.3-1.91.7-2.6-1.9-1.50.1
Locomotion velocity, hab. session 13.44.77.4-2.5-2.5-2.6-2.6-2.4-2.11.9-2.7-1.5-1.60.0
Time in familiar zone, hab. session 20.30.42.10.10.1-0.3-0.1-0.1-0.1-0.1-0.9-1.40.40.8
Time in novel zone, hab. session 20.30.31.7-0.0-0.00.30.20.10.20.00.91.3-0.5-0.7
Total zone transitions, hab. session 22.22.84.5-2.0-2.0-1.6-2.0-1.8-1.51.4-1.50.8-2.1-1.4
Total locomotion distance, hab. session 21.21.62.5-1.5-1.5-1.3-1.5-1.6-1.51.4-1.10.6-1.1-0.3
Locomotion velocity, hab. session 22.02.64.0-1.9-1.9-1.6-2.0-2.0-1.91.8-1.50.6-1.4-0.3
Novel to familiar place preference ratio1.92.13.41.61.61.61.71.71.9-1.71.5-0.20.8-0.3
Novelty place preference2.62.84.91.91.91.82.02.02.2-2.01.8-0.40.9-0.4
Time in novel zone, NPP test3.33.55.92.12.12.02.22.32.4-2.22.0-0.31.0-0.6
Total zone transitions, NPP test4.46.410.2-3.2-3.2-3.0-3.1-2.8-2.32.2-2.8-1.2-1.9-0.9
Total locomotion distance, NPP test2.12.84.5-2.1-2.1-2.0-2.1-2.0-1.71.6-1.7-0.4-1.3-0.5
Locomotion velocity, NPP test2.73.95.9-2.4-2.4-2.3-2.4-2.3-2.11.9-2.1-0.7-1.2-0.1
Intraocular pressure0.30.51.40.30.30.40.30.60.8-0.80.90.1-1.2-0.9
Delta distance traveled before/after self-admin0.60.72.30.30.60.50.10.40.5-1.00.61.1-1.2-1.5
Delta ambulatory time before/after self-admin0.60.83.20.20.40.60.20.40.6-0.90.71.2-1.3-1.8
Parametrial fat weight0.10.21.50.20.2-0.10.20.20.3-0.20.1-1.20.30.7
Pavlov. Cond. lever latency0.30.40.70.70.70.70.60.80.7-0.80.50.0-0.1-0.3
Pavlov. Cond. magazine entry latency0.40.50.8-0.9-0.9-0.7-0.8-0.8-0.60.7-0.30.4-0.6-0.5
Pavlov. Cond. change in total contacts1.21.31.9-1.4-1.4-1.0-1.3-1.3-1.11.2-0.61.1-0.9-0.8
Pavlov. Cond. index score0.20.20.4-0.6-0.6-0.4-0.5-0.5-0.40.5-0.10.6-0.4-0.5
Pavlov. Cond. latency score0.10.20.3-0.5-0.5-0.4-0.4-0.5-0.40.5-0.10.4-0.1-0.2
Pavlov. Cond. lever contacts1.01.21.9-1.3-1.3-1.2-1.1-1.4-1.31.4-1.10.0-0.20.4
Pavlov. Cond. magazine entry number0.50.61.01.01.00.81.00.80.7-0.70.3-0.40.80.7
Pavlov. Cond. intertrial magazine entries0.80.91.4-1.1-1.1-0.9-1.1-1.2-1.21.1-1.00.6-0.7-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.30.6-0.8-0.8-0.6-0.6-0.6-0.40.6-0.30.4-0.5-0.6
Pavlov. Cond. response bias0.50.71.1-1.1-1.1-0.9-0.9-1.0-0.80.9-0.50.4-0.6-0.4
Pavlov. Cond. lever latency0.60.81.60.70.70.60.70.91.2-1.30.7-0.2-1.1-1.0
Pavlov. Cond. magazine entry latency1.62.03.6-1.6-1.6-1.3-1.6-1.7-1.91.9-0.91.0-0.40.2
Pavlov. Cond. change in total contacts0.30.54.0-0.3-0.30.1-0.2-0.4-0.70.80.52.00.3-0.2
Pavlov. Cond. index score0.91.22.5-1.2-1.2-1.0-1.2-1.3-1.61.6-0.90.60.30.5
Pavlov. Cond. latency score1.31.73.4-1.5-1.5-1.3-1.5-1.6-1.81.8-1.00.60.20.4
Pavlov. Cond. lever contacts0.71.02.1-0.9-0.9-0.8-0.8-1.1-1.41.4-0.90.11.01.1
Pavlov. Cond. magazine entry number0.81.01.91.21.21.01.21.21.4-1.40.6-0.70.2-0.0
Pavlov. Cond. intertrial magazine entries1.32.03.01.51.51.61.41.61.7-1.71.41.0-0.2-1.2
Pavlov. Cond. lever-magazine prob. diff.1.01.32.8-1.2-1.2-1.0-1.2-1.4-1.71.7-0.90.60.40.7
Pavlov. Cond. response bias0.60.81.8-0.8-0.8-0.7-0.8-1.0-1.31.3-0.60.80.50.5
Time in closed arm before self-admin3.03.98.1-2.1-2.0-1.6-1.7-2.3-2.42.9-2.00.70.12.2
Time in closed arm after self-admin0.20.21.1-0.3-0.10.30.20.20.10.20.31.0-0.70.2
Time in open arm before self-admin0.10.10.3-0.2-0.2-0.20.10.20.4-0.30.4-0.60.2-0.2
Time in open arm after self-admin0.30.41.30.20.2-0.7-0.6-0.6-0.5-0.3-0.9-1.1-0.40.4
Bone: periosteal estimation1.12.23.81.71.71.91.61.61.4-1.41.02.0-0.9-0.4
Bone: periosteal perimeter2.74.77.22.72.72.72.52.52.3-2.41.91.7-0.3-0.5
Bone: post-yield work0.71.04.00.20.20.60.10.40.5-0.50.92.0-1.5-1.7
Progressive ratio test 1 active lever presses0.60.83.2-0.2-0.30.70.40.50.60.20.51.2-1.8-1.5
Progressive ratio test 1 breakpoint0.60.73.3-0.3-0.40.50.30.40.60.20.51.0-1.8-1.5
Progressive ratio test 1 inactive lever presses0.30.52.00.80.80.90.60.40.2-0.30.11.4-0.3-0.3
Progressive ratio test 2 active lever presses0.70.83.8-0.4-0.50.30.00.10.40.10.31.1-2.0-1.7
Progressive ratio test 2 breakpoint0.70.83.9-0.5-0.50.2-0.10.10.40.20.21.1-2.0-1.7
Progressive ratio test 2 inactive lever presses0.50.71.8-1.0-1.0-0.6-0.8-0.9-0.81.0-1.0-0.0-1.3-0.2
Incentive Sensitization - Responses0.20.30.7-0.8-0.8-0.6-0.6-0.5-0.40.4-0.5-0.5-0.6-0.7
Incentive Sensitization - Breakpoint0.20.20.7-0.6-0.6-0.4-0.4-0.3-0.20.2-0.3-0.3-0.5-0.8
Sum of active levers in priming session hrs 5-60.10.10.20.30.20.30.30.40.2-0.10.2-0.00.40.4
Progressive ratio0.10.10.40.10.10.1-0.1-0.0-0.30.3-0.40.5-0.10.6
Food seeking constrained by brief footshock0.91.01.71.11.01.20.81.31.0-1.30.80.3-0.7-1.3
Seeking ratio, punishment vs. effort0.40.61.50.70.60.70.60.70.8-1.00.90.4-0.4-1.2
Retroperitoneal fat weight3.916.625.24.74.74.64.85.04.8-4.74.51.11.3-1.1
Reaction time number correct0.81.63.3-1.5-1.5-1.6-1.4-1.1-0.91.0-1.5-1.8-0.20.2
Reaction time mean minus median0.10.20.80.60.60.40.50.30.3-0.2-0.0-0.20.30.9
Reaction time mean minus median AUC0.41.11.81.41.41.11.31.11.0-1.00.7-0.40.80.9
Reaction time num false alarms0.10.21.0-0.1-0.1-0.3-0.2-0.3-0.30.4-0.6-0.50.31.0
Reaction time num false alarms AUC0.20.40.9-0.4-0.4-0.6-0.5-0.6-0.50.5-0.9-0.80.10.8
Reaction time trials correct on left0.81.63.3-1.5-1.5-1.6-1.4-1.1-0.91.0-1.5-1.8-0.20.2
Reaction time trials on left0.91.83.4-1.6-1.6-1.6-1.4-1.2-1.01.1-1.6-1.9-0.20.2
Reaction time mean0.20.31.5-0.0-0.0-0.10.1-0.2-0.40.50.1-0.31.01.2
Reaction time mean AUC0.10.20.9-0.1-0.1-0.10.1-0.2-0.30.40.2-0.30.80.9
Median of all reaction times0.20.31.2-0.3-0.3-0.3-0.1-0.4-0.60.70.2-0.31.01.1
Reaction time omissions0.30.50.9-0.7-0.7-0.8-0.8-0.7-0.70.6-1.0-0.7-0.60.3
Reaction time false alarm rate0.10.20.70.50.50.30.30.10.0-0.1-0.10.00.50.8
Reaction time premature initiation rate0.30.42.6-0.3-0.30.1-0.2-0.2-0.60.70.61.60.2-0.1
Reaction time premature initiations0.20.30.6-0.8-0.8-0.4-0.6-0.5-0.70.80.20.70.0-0.2
Std. dev. reaction times0.20.40.80.80.80.60.70.50.4-0.40.4-0.30.70.9
Reaction time trials completed0.91.83.4-1.6-1.6-1.6-1.4-1.2-1.01.1-1.6-1.9-0.20.2
Reaction time trials AUC0.61.22.6-1.3-1.3-1.4-1.2-1.0-0.80.9-1.3-1.6-0.20.2
Run reversals in cocaine runway, females0.70.71.9-1.0-1.0-0.8-0.6-0.7-0.40.7-1.1-1.4-0.10.1
Run reversals in cocaine runway, males1.11.14.8-0.1-0.10.40.30.61.3-0.90.70.3-2.2-1.8
Latency to leave start box in cocaine runway0.50.61.21.01.10.60.90.80.7-0.80.80.00.70.5
Latency to leave start box in cocaine runway, F0.00.00.20.10.1-0.1-0.0-0.1-0.10.0-0.0-0.10.30.4
Latency to leave start box in cocaine runway, M1.51.42.81.51.71.11.41.21.1-1.31.30.21.00.5
Std. dev. time between licks in bursts1.01.32.3-1.3-1.3-1.1-1.3-1.4-1.51.5-1.10.1-0.10.1
Total sessions with >9 infusions3.64.37.41.81.92.62.32.32.3-1.82.71.80.1-2.0
Short access day 1 total inactive lever presses1.11.55.31.31.41.40.90.60.6-0.90.82.3-1.0-1.3
Short access day 10 total inactive lever presses0.40.92.61.61.40.90.90.70.7-1.30.40.9-0.4-0.0
Short access day 1 total infusions0.70.92.01.11.21.41.20.90.9-0.70.70.80.3-0.8
Short access day 10 total infusions1.62.14.61.31.21.71.51.51.4-0.82.12.1-0.3-0.8
Short access total infusions1.92.54.41.21.32.11.71.61.6-1.01.91.9-0.5-1.8
Short access day 1 locomotion0.50.61.20.71.01.11.10.70.6-0.30.60.51.10.3
Short access day 10 total locomotion0.40.72.21.10.90.40.4-0.3-0.50.10.31.21.11.5
Short access total locomotion1.31.62.51.51.61.61.51.00.9-0.81.51.41.20.3
One hour access (0.3 mA shock)0.10.10.3-0.00.1-0.1-0.2-0.3-0.40.2-0.00.5-0.60.3
Compulsive drug intake0.80.94.3-0.8-0.8-1.0-1.2-0.9-0.2-0.30.2-0.0-1.0-2.1
One hour access (shock baseline)0.20.32.10.30.40.40.50.2-0.30.5-0.20.20.21.5
Social response proportion1.21.45.61.11.11.01.20.60.2-0.21.30.42.41.5
Social responses0.10.10.3-0.4-0.4-0.4-0.4-0.5-0.30.3-0.10.1-0.6-0.3
Social time1.52.03.3-1.5-1.5-1.6-1.7-1.7-1.81.6-1.6-0.2-0.40.5
Soleus weight0.20.71.9-1.0-1.0-0.8-1.0-0.8-0.40.5-0.70.4-0.8-1.4
Bone: stiffness1.62.66.51.71.72.01.71.51.3-1.31.82.5-0.3-0.7
Tibialis anterior weight0.51.53.0-1.4-1.4-1.3-1.2-1.5-1.51.5-1.70.1-0.20.4
Time to tail flick, vehicle, before self-admin0.10.10.50.20.00.1-0.0-0.0-0.00.10.20.7-0.5-0.1
Time to tail flick, vehicle, after self-admin1.21.64.7-1.4-1.2-1.2-1.3-1.2-1.31.0-2.2-1.2-1.00.6
Time to tail flick, test, before self-admin0.50.51.10.50.60.50.70.81.0-1.00.4-0.7-0.6-0.5
Time to tail flick, test, after self-admin0.40.40.9-1.0-0.8-0.6-0.5-0.5-0.40.9-0.7-0.9-0.00.3
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.10.10.10.00.0-0.1-0.0-0.7-0.5-0.10.2
Delta time to tail flick, test, before/after SA2.72.74.6-1.8-1.8-1.6-1.7-1.8-1.92.1-1.9-1.20.71.0
Tibia length0.72.14.31.01.01.41.11.51.8-1.51.61.4-1.1-2.1
Ambulatory time before self-admin0.40.61.5-1.1-0.9-0.6-0.6-0.8-0.81.2-0.5-0.30.10.5
Ambulatory time after self-admin1.11.32.8-1.7-1.2-1.1-1.4-1.5-1.31.2-0.90.2-0.7-0.5
Bone: tissue strength0.20.20.30.30.30.40.40.50.5-0.40.60.10.1-0.4
Total heroin consumption0.40.52.0-0.3-0.30.60.50.50.8-0.10.80.9-0.8-1.4
Bone: trabecular number0.00.00.3-0.1-0.1-0.1-0.10.00.0-0.0-0.4-0.50.20.2
Bone: trabecular spacing1.72.24.21.21.21.51.31.31.5-1.41.82.1-1.3-1.6
Bone: trabecular thickness0.60.72.7-0.2-0.2-0.3-0.1-0.3-0.70.8-0.9-0.81.51.6
Bone: trabecular tissue density1.32.03.6-1.2-1.2-1.2-1.1-1.6-1.91.9-1.4-0.31.21.7
Water consumed over 24 hours0.30.41.70.30.30.50.30.50.7-0.60.60.5-0.9-1.3
Number of responses in last shaping day0.80.85.1-0.5-0.40.1-0.1-0.7-0.71.4-0.32.30.30.7