Hub : Genes

Xbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Xbp1 0.52 0.17 1.3e-12 0.37 0.39 0.29 0.39 9.3e-10 2.3e-10 1.3e-07 2.3e-10
2 pVTA gene expression Xbp1 0.31 0.13 0.0e+00 0.33 0.33 0.34 0.34 5.2e-27 1.5e-27 5.7e-28 2.3e-28
3 LHb mRNA stability Xbp1 0.42 0.19 4.2e-09 0.3 0.29 0.2 0.32 7.8e-08 1.5e-07 1.3e-05 2.5e-08
4 OFC mRNA stability Xbp1 0.51 0.16 2.6e-12 0.35 0.36 0.34 0.37 2.8e-09 2.1e-09 6.5e-09 1.2e-09
5 NAcc mRNA stability Xbp1 0.37 0.14 0.0e+00 0.36 0.37 0.37 0.37 2.4e-57 1.5e-58 7.1e-59 6.1e-59
6 PL mRNA stability Xbp1 0.4 0.15 0.0e+00 0.43 0.45 0.44 0.45 1.5e-51 5.9e-54 1.2e-52 1.2e-54
7 RMTg mRNA stability Xbp1 0.47 0.18 2.8e-08 0.32 0.31 0.34 0.34 4.0e-09 5.9e-09 6.4e-10 8.0e-10
8 Brain mRNA stability Xbp1 0.54 0.14 0.0e+00 0.55 0.54 0.55 0.55 1.6e-61 3.4e-60 2.4e-61 3.6e-61
9 BLA mRNA stability Xbp1 0.25 0.13 6.3e-13 0.17 0.22 0.21 0.19 1.4e-09 6.3e-12 3.7e-11 2.3e-10
10 Adipose mRNA stability Xbp1 0.14 0.07 0.0e+00 0.17 0.16 0.15 0.16 1.2e-18 1.1e-17 3.5e-16 1.4e-17
11 IC mRNA stability Xbp1 0.33 0.14 0.0e+00 0.37 0.39 0.38 0.39 2.2e-16 2.1e-17 4.5e-17 1.1e-17
12 Eye mRNA stability Xbp1 0.38 0.18 1.4e-03 0.06 0.17 0.1 0.15 5.2e-02 1.6e-03 1.3e-02 2.9e-03
13 pVTA mRNA stability Xbp1 0.87 0.09 0.0e+00 0.49 0.48 0.47 0.48 3.1e-44 3.2e-43 1.8e-42 9.4e-44
14 Liver mRNA stability Xbp1 0.15 0.07 0.0e+00 0.18 0.18 0.18 0.18 5.5e-20 1.1e-19 1.4e-19 7.0e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.5-0.6-0.5-0.7-0.7-0.2-0.60.00.2-0.40.3-0.3-0.40.50.3
Area under the delay curve2.53.94.92.22.02.22.21.81.9-2.0-1.92.1-1.81.91.9-1.8-1.8
BMI with tail0.00.10.40.20.20.20.20.20.40.1-0.60.5-0.20.20.5-0.1-0.6
BMI without tail0.21.02.11.00.91.01.00.80.8-1.5-1.01.0-0.90.90.9-0.8-1.1
Body weight1.35.96.62.52.52.52.52.32.4-2.5-2.62.5-2.32.32.4-2.2-2.5
Weight adjusted by age0.10.41.30.80.60.80.80.60.3-1.1-0.40.6-0.70.70.5-0.4-0.4
Bone surface0.10.30.60.30.50.20.20.80.4-0.5-0.70.5-0.60.60.5-0.3-0.4
Bone volume0.10.20.50.20.40.10.10.70.2-0.5-0.70.4-0.50.50.4-0.2-0.4
Breakpoint value in progressive ratio session0.30.60.70.80.80.80.80.80.6-0.9-0.70.8-0.70.70.8-0.7-0.8
Number of licking bursts1.13.43.81.81.91.81.81.81.8-1.9-1.91.9-1.91.91.8-1.9-1.8
Context. condit. distance diff. score3.84.65.4-2.3-2.3-2.3-2.3-2.1-2.22.11.9-2.22.1-2.1-2.12.21.8
Locomotion velocity, session 10.10.20.90.30.30.30.30.20.71.0-0.20.2-0.30.30.2-0.40.3
Locomotion distance, session 10.81.01.4-1.2-1.2-1.1-1.1-1.1-1.20.50.9-0.80.8-0.9-1.01.00.9
Locomotion velocity, session 20.10.11.00.20.20.10.10.30.51.0-0.40.1-0.20.30.3-0.1-0.2
Locomotion distance, session 21.62.33.8-1.7-1.8-1.7-1.7-1.4-1.42.01.1-1.31.4-1.4-1.31.71.0
Locomotion velocity, session 33.03.44.4-2.1-2.0-2.1-2.1-1.7-1.91.61.3-1.81.9-1.8-1.82.01.6
Locomotion distance, session 30.20.21.1-0.1-0.0-0.1-0.10.6-0.0-0.0-1.10.40.00.20.40.2-0.8
Stereotopy head waving bouts, day 31.01.21.6-1.3-1.2-1.2-1.2-1.1-1.20.81.1-1.00.9-1.1-1.01.10.7
Stereotopy head waving duration, day 32.22.73.5-1.6-1.7-1.6-1.6-1.9-1.51.61.9-1.71.6-1.7-1.71.61.6
Locomotion velocity, session 70.20.20.50.50.40.40.40.60.4-0.2-0.70.5-0.50.50.5-0.2-0.5
Locomotion distance, session 70.20.20.9-0.5-0.5-0.6-0.6-0.2-0.51.00.1-0.40.3-0.3-0.30.60.2
Stereotopy head waving bouts, day 70.00.00.2-0.00.0-0.1-0.1-0.2-0.0-0.00.4-0.30.1-0.1-0.2-0.00.3
Stereotopy head waving duration, day 70.00.00.1-0.2-0.1-0.2-0.2-0.2-0.1-0.20.3-0.20.1-0.1-0.3-0.00.3
Locomotion velocity, session 81.21.53.8-1.2-1.2-1.3-1.3-1.0-1.02.00.7-1.21.1-1.1-1.01.31.0
Locomotion distance, session 87.911.413.3-3.6-3.6-3.6-3.6-3.3-3.43.52.9-3.43.3-3.4-3.23.52.9
Degree of sensitization distance1.61.72.9-1.2-1.1-1.1-1.1-1.4-1.01.71.6-1.51.0-1.2-1.41.01.7
Degree of sensitization stereotypy0.10.10.30.40.50.40.40.20.4-0.5-0.10.2-0.20.30.2-0.6-0.1
Conditioned locomotion1.41.62.4-1.5-1.6-1.4-1.4-1.3-1.50.71.1-1.11.2-1.3-1.21.51.0
Cocaine response after cond. corrected1.42.12.71.61.61.61.61.41.5-1.6-1.11.4-1.51.41.3-1.5-1.1
Cocaine response after cond. not corrected1.62.34.11.71.61.71.71.41.4-2.0-1.11.4-1.51.41.3-1.6-1.2
Cocaine response before conditioning0.40.50.7-0.7-0.8-0.6-0.7-0.8-0.80.20.8-0.70.7-0.8-0.80.80.7
Saline control response0.50.71.7-0.9-0.8-0.9-0.9-0.6-0.71.30.5-0.71.0-0.7-0.60.90.5
Bone: connectivity density0.20.30.6-0.7-0.6-0.8-0.8-0.4-0.70.30.5-0.60.4-0.5-0.60.70.5
Bone: cortical apparent density0.61.01.50.91.10.90.91.01.0-1.1-1.00.9-1.21.10.9-1.2-0.9
Bone: cortical area2.23.54.51.91.91.91.81.91.7-2.1-2.01.9-2.01.91.8-1.8-1.5
Bone: cortical porosity0.00.00.10.10.20.10.10.20.2-0.3-0.10.10.00.10.1-0.2-0.1
Bone: cortical porosity0.20.20.3-0.5-0.4-0.4-0.4-0.5-0.40.10.5-0.40.5-0.5-0.50.30.4
Bone: cortical thickness1.32.24.31.41.41.31.31.51.2-2.1-1.81.6-1.61.51.4-1.3-1.3
Bone: cortical thickness0.91.11.8-1.2-1.2-1.1-1.2-1.0-1.30.21.0-1.00.9-1.1-1.11.11.1
Bone: cortical tissue density0.71.11.61.01.21.01.01.11.1-1.1-1.10.9-1.31.11.0-1.2-0.9
Condit. Reinf. active minus inactive responses1.01.12.11.01.00.90.91.21.20.1-1.21.1-1.11.01.3-0.8-1.5
Condit. Reinf. active-inactive response ratio0.20.21.70.40.30.30.30.30.61.3-0.20.1-0.40.30.4-0.1-0.5
Condit. Reinf. active responses0.40.61.10.60.60.50.51.00.80.1-1.00.9-0.70.70.9-0.5-1.1
Condit. Reinf. inactive responses0.10.20.60.10.20.00.00.60.0-0.7-0.70.5-0.20.30.4-0.2-0.5
Incentive salience index mean1.21.52.91.11.11.01.01.41.2-0.4-1.41.4-1.21.21.4-0.9-1.7
Condit. Reinf. lever presses0.20.30.70.30.30.30.30.70.3-0.6-0.80.8-0.50.50.7-0.2-0.8
Condit. Reinf. active minus inactive responses0.40.60.8-0.9-0.8-0.9-0.9-0.7-0.80.90.8-0.70.9-0.8-0.70.90.7
Condit. Reinf. active-inactive response ratio0.00.00.1-0.2-0.2-0.2-0.2-0.1-0.10.30.10.00.0-0.1-0.00.2-0.1
Condit. Reinf. active responses0.60.91.3-1.0-1.0-1.0-1.0-0.8-0.81.11.0-0.91.0-0.9-0.91.00.9
Condit. Reinf. inactive responses0.60.91.6-0.9-0.9-0.9-0.9-0.9-0.81.31.1-1.01.0-1.0-1.00.91.1
Condit. Reinf. lever presses0.50.81.0-1.0-0.9-1.0-1.0-0.7-0.90.80.9-0.80.9-0.8-0.81.00.7
Condit. Reinf. lever reinforcers received0.50.71.0-0.9-0.8-0.9-0.9-0.7-0.71.00.9-0.70.8-0.8-0.70.80.7
Conditioned reinforcement - actives0.10.30.80.70.60.80.80.50.4-0.9-0.50.5-0.40.50.5-0.4-0.4
Conditioned reinforcement - inactives0.41.11.41.21.11.21.21.11.0-0.8-1.01.0-0.91.01.0-1.0-0.8
Conditioned locomotion0.81.22.01.31.11.31.41.10.8-1.4-1.01.0-1.01.01.0-1.1-1.0
Patch foraging indifference point 0 sec1.13.24.41.91.91.81.81.81.5-1.9-1.91.5-1.71.61.7-1.6-2.1
Patch foraging indifference point AUC0.00.10.20.30.40.20.30.40.4-0.0-0.20.2-0.30.30.3-0.3-0.2
Delay disc. indifference point, 0s delay1.11.22.41.21.21.21.21.01.0-1.5-1.01.0-1.01.11.0-1.0-0.8
Delay disc. indifference point, 16s delay1.92.73.81.91.62.02.01.51.7-1.2-1.61.7-1.51.61.7-1.4-1.5
Delay disc. indifference point, 2s delay1.21.43.61.21.11.21.20.90.8-1.9-0.91.3-1.11.11.1-1.0-1.2
Delay disc. indifference point, 24s delay1.01.62.11.31.21.31.31.21.3-0.9-1.21.4-1.31.31.3-1.3-1.4
Delay disc. indifference point, 4s delay2.93.14.61.91.81.91.91.61.6-2.1-1.61.8-1.71.71.7-1.7-1.7
Delay disc. indifference point, 8s delay0.71.21.71.21.11.31.31.01.1-0.9-1.11.2-1.01.11.1-1.0-0.9
Indifference point function ln k0.00.00.1-0.3-0.3-0.3-0.4-0.1-0.3-0.2-0.10.00.1-0.1-0.10.10.1
Indifference point function log k0.00.00.1-0.3-0.3-0.3-0.4-0.1-0.3-0.2-0.10.00.1-0.1-0.10.10.1
Patch foraging total patch changes 0 sec1.13.24.71.91.91.81.81.81.6-1.8-1.91.6-1.71.71.8-1.6-2.2
Patch foraging total patch changes 12 sec1.21.62.01.41.41.31.31.21.1-1.3-1.21.0-1.21.11.2-1.2-1.4
Patch foraging total patch changes 18 sec1.22.83.71.91.91.81.81.71.9-0.8-1.61.4-1.51.61.7-1.7-1.7
Patch foraging total patch changes 24 sec0.31.11.8-0.8-1.0-0.8-0.8-1.1-1.01.31.0-1.31.2-1.2-1.01.20.5
Patch foraging total patch changes 6 sec1.83.04.61.71.81.61.61.91.6-1.4-2.01.6-1.71.71.8-1.6-2.2
Patch foraging time to switch 0 sec0.20.61.1-0.7-0.9-0.5-0.5-1.0-0.80.51.0-0.80.8-0.9-0.90.70.9
Patch foraging water rate 0 sec0.83.04.01.71.81.61.61.91.7-1.2-2.01.7-1.61.81.8-1.6-2.0
Patch foraging water rate 12 sec0.00.10.30.10.20.00.00.30.10.1-0.50.3-0.20.30.30.0-0.4
Patch foraging water rate 18 sec0.10.20.5-0.4-0.5-0.3-0.3-0.7-0.7-0.70.4-0.30.4-0.5-0.50.50.2
Patch foraging water rate 24 sec0.10.10.20.30.30.30.30.30.40.3-0.30.3-0.40.30.3-0.2-0.2
Patch foraging water rate 6 sec0.30.40.60.60.60.60.60.60.5-0.8-0.70.7-0.70.70.6-0.4-0.5
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.1-0.30.10.1-0.5-0.2-0.00.6-0.20.4-0.3-0.30.20.4
Distance traveled before self-admin0.10.21.10.40.40.40.40.30.3-1.1-0.30.2-0.20.30.2-0.1-0.3
Distance traveled after self-admin0.00.10.8-0.1-0.1-0.1-0.1-0.0-0.3-0.90.1-0.00.1-0.1-0.10.1-0.2
Extensor digitorum longus weight3.212.914.43.63.73.53.53.83.3-3.7-3.63.6-3.73.73.5-3.5-3.5
Bone: elastic displacement0.50.60.8-0.8-0.7-0.8-0.8-0.8-0.80.10.7-0.90.8-0.9-0.90.60.7
Bone: elastic work0.10.11.0-0.00.10.00.0-0.1-0.1-1.0-0.10.0-0.2-0.1-0.0-0.2-0.3
Bone: endosteal estimation0.00.10.20.40.40.40.40.10.2-0.50.00.2-0.20.30.2-0.4-0.2
Bone: endosteal perimeter0.51.21.51.21.21.21.21.01.1-1.0-0.81.1-1.11.11.0-1.2-0.7
Epididymis fat weight0.21.11.40.91.00.80.81.21.0-1.1-1.11.1-1.11.11.0-0.9-1.1
Delta time in closed arm before/after self-admin10.29.610.7-3.2-3.2-3.0-3.0-3.2-2.92.83.3-3.13.2-3.1-3.13.13.3
Delta time in open arm before/after self-admin6.88.110.13.23.03.13.12.73.0-2.6-2.82.7-2.62.72.8-2.6-2.7
Diff in mean of infusions in LGA sessions0.10.10.2-0.3-0.3-0.2-0.2-0.5-0.30.10.4-0.20.4-0.3-0.30.40.2
Delay discount exponential model param2.73.74.6-2.1-1.9-2.1-2.1-1.8-1.81.91.8-2.01.8-1.9-1.91.81.7
Extinction: sum of active levers before priming0.10.10.30.20.30.20.20.50.50.2-0.30.4-0.30.30.4-0.3-0.5
Active lever presses in extinction session 60.10.10.3-0.2-0.4-0.1-0.2-0.3-0.3-0.20.5-0.30.5-0.4-0.40.40.5
Bone: final force0.20.40.60.60.60.60.60.50.4-0.7-0.70.5-0.60.50.6-0.5-0.8
Bone: final moment0.30.50.80.70.70.70.70.70.6-0.9-0.80.7-0.70.70.7-0.6-0.9
Food consumed during 24 hour testing period1.42.83.91.51.81.41.42.01.8-0.8-1.71.7-2.01.91.8-1.6-1.7
Glucose21.133.543.66.26.35.95.96.26.6-2.2-5.85.5-6.06.06.0-5.8-5.3
Heart weight0.20.40.90.50.60.40.40.70.70.5-0.80.5-0.50.60.7-0.6-1.0
Delay discount hyperbolic model param2.83.64.5-2.1-1.9-2.1-2.1-1.7-1.82.01.8-2.01.8-1.9-1.91.81.8
Intermittent access intake day 1-15 change0.31.52.01.21.21.11.11.41.4-0.6-1.41.2-1.21.21.3-1.2-1.3
Intermittent access intake escalation0.21.21.91.01.10.90.91.31.3-0.4-1.41.1-1.11.11.2-1.1-1.2
Intermittent access intake escalation 20.20.40.80.60.60.50.50.70.7-0.2-0.90.5-0.60.60.7-0.6-0.7
Intermitt. access day 1 inactive lever presses0.00.20.4-0.5-0.3-0.4-0.4-0.4-0.20.60.6-0.40.4-0.4-0.40.40.5
Intermitt. access day 15 inactive lever presses0.52.93.51.61.71.61.61.81.8-0.5-1.71.8-1.91.81.8-1.8-1.8
Intermitt. access escalation Index0.10.20.50.20.30.10.10.60.70.7-0.50.3-0.40.30.5-0.4-0.6
Intermittent access day 1 total infusions0.10.31.40.70.40.80.80.1-0.1-1.2-0.10.3-0.20.30.2-0.2-0.1
Intermittent access day 15 total infusions1.12.83.71.91.71.91.91.71.4-1.7-1.71.6-1.51.61.6-1.4-1.6
Intermittent access terminal intake (last 3 days)0.91.52.61.61.21.61.61.10.9-1.6-1.21.0-0.91.01.1-0.9-1.1
Intermittent access total infusions1.21.42.61.51.21.51.51.10.8-1.6-1.11.1-0.91.01.1-0.9-1.1
Intermittent access day 1 locomotion0.10.10.3-0.0-0.30.10.1-0.4-0.6-0.40.4-0.30.3-0.3-0.40.30.5
Intermittent access day 15 total locomotion0.41.42.11.41.11.51.51.11.1-1.4-1.11.2-1.01.11.1-1.1-1.0
Intermittent access total locomotion1.11.42.11.41.11.41.41.10.9-1.4-1.21.2-0.91.01.1-0.9-1.1
Intermittent access standard deviation0.10.60.9-0.7-0.7-0.7-0.7-0.7-0.90.40.9-0.90.7-0.7-0.90.80.8
Left kidney weight0.00.20.90.30.40.40.3-0.10.3-0.9-0.20.3-0.40.20.1-0.5-0.3
Right kidney weight0.00.21.2-0.3-0.3-0.2-0.2-0.4-0.5-1.1-0.0-0.20.2-0.3-0.40.20.0
Cocaine induced anxiety1.54.05.51.92.01.81.82.31.9-1.6-2.42.0-2.12.02.0-1.9-2.1
Post-drug Anxiety2.83.14.11.61.81.51.52.01.8-1.1-2.01.8-1.91.91.8-1.8-1.9
Baseline Anxiety0.10.10.5-0.3-0.3-0.3-0.3-0.4-0.00.70.7-0.30.2-0.2-0.30.20.4
Tail length1.89.614.03.13.13.03.03.02.7-3.7-3.23.1-3.13.12.9-3.0-3.2
Length with tail2.29.813.03.23.23.13.13.12.8-3.6-3.23.1-3.13.13.0-3.0-3.1
Length without tail0.10.71.20.80.80.70.70.90.7-0.8-1.11.0-0.80.90.9-0.7-1.1
Times rat made contact with spout0.20.30.80.40.50.20.30.70.70.9-0.60.1-0.60.50.5-0.3-0.1
Lifetime Intake1.01.22.91.41.11.51.50.90.6-1.7-0.90.9-0.70.90.9-0.7-0.9
Liver weight, left0.40.71.0-0.9-0.9-0.8-0.9-0.9-0.9-0.00.8-0.80.8-0.8-1.00.71.0
Liver weight, right1.32.22.8-1.5-1.6-1.4-1.4-1.6-1.60.61.5-1.41.4-1.4-1.61.61.7
Locomotor activity0.81.32.01.41.31.41.41.01.3-0.7-0.81.0-1.31.11.1-1.1-1.0
Locomotor testing distance0.20.51.60.70.70.80.80.50.5-1.3-0.40.6-0.90.60.5-0.8-0.6
Locomotor testing rearing0.93.24.21.91.91.81.81.81.7-1.7-1.61.6-2.01.81.7-1.8-1.7
Locomotion in novel chamber3.34.45.3-2.0-2.1-2.0-2.0-2.1-2.31.62.0-2.22.1-2.1-2.22.32.3
Locomotion in novel chamber post-restriction1.13.46.3-1.9-2.0-1.8-1.8-1.9-1.52.51.7-1.71.7-1.8-1.71.71.9
Fecal boli incidents, locomotor time 10.00.10.2-0.4-0.4-0.3-0.4-0.3-0.30.30.4-0.20.1-0.2-0.30.10.4
Change in fecal boli incidents, locomotor task0.30.30.60.50.60.50.50.60.80.4-0.60.4-0.60.60.5-0.5-0.4
Time >=10cm from walls, locomotor time 10.00.10.6-0.00.00.00.00.00.20.20.3-0.1-0.20.1-0.1-0.20.7
Bouts of movement, locomotor time 10.50.60.90.90.90.90.91.00.8-0.0-0.80.7-0.80.80.9-0.8-0.7
Total resting periods, locomotor time 10.20.20.30.50.40.40.50.50.40.4-0.40.3-0.40.40.5-0.4-0.3
Rest time, locomotor task time 10.00.10.20.10.20.00.00.50.30.2-0.20.3-0.40.30.2-0.30.1
Distance moved, locomotor task time 10.10.30.60.50.50.60.60.20.4-0.8-0.40.4-0.40.40.4-0.5-0.7
Vertical activity count, locomotor time 10.00.10.30.40.30.50.5-0.00.2-0.6-0.20.2-0.20.20.2-0.2-0.4
Time >=10cm from walls, locomotor time 20.10.31.5-0.1-0.30.10.0-0.7-0.30.20.8-0.40.3-0.3-0.50.31.2
Bouts of movement, locomotor time 20.00.00.30.0-0.20.20.1-0.1-0.1-0.00.10.30.2-0.10.10.1-0.5
Total resting periods, locomotor time 20.00.10.50.2-0.00.20.20.10.10.10.00.40.00.00.30.0-0.7
Rest time, locomotor task time 20.00.10.3-0.4-0.3-0.4-0.40.0-0.20.50.3-0.20.1-0.1-0.10.10.0
Distance moved, locomotor task time 20.10.10.3-0.2-0.2-0.2-0.2-0.3-0.20.10.3-0.30.2-0.2-0.30.10.6
Vertical activity count, locomotor time 20.00.10.5-0.0-0.10.10.0-0.2-0.2-0.30.1-0.10.1-0.1-0.20.10.7
Light reinforcement 10.00.20.80.30.30.30.30.40.0-0.9-0.50.3-0.30.30.2-0.3-0.4
Light reinforcement 20.10.11.00.40.30.50.5-0.00.1-1.0-0.10.3-0.20.20.1-0.20.0
Bone: marrow area0.00.00.10.30.20.30.3-0.00.1-0.30.10.1-0.10.10.1-0.2-0.0
Bone: maximum diameter4.28.59.73.13.13.03.03.13.1-2.2-2.83.0-3.03.03.0-2.9-2.6
Bone: maximum force0.10.20.70.50.40.40.40.40.3-0.8-0.50.4-0.50.50.4-0.3-0.5
Bone: maximum moment0.20.41.20.60.60.60.60.60.4-1.1-0.70.6-0.70.60.6-0.5-0.7
Mean time between licks in bursts0.21.01.61.01.11.01.00.91.30.0-1.01.0-1.11.11.1-1.0-0.8
Mean num. licks in bursts0.72.05.0-1.3-1.3-1.4-1.3-1.1-1.12.21.2-1.51.3-1.3-1.21.41.4
Cd content in liver0.60.70.90.90.90.80.80.90.9-0.4-0.80.8-0.90.90.9-0.8-1.0
Co content in liver0.20.31.10.30.50.20.20.50.4-0.7-0.40.4-0.50.40.5-0.6-1.1
Cu content in liver0.30.30.60.50.60.40.40.60.7-0.0-0.50.5-0.70.60.5-0.6-0.5
Fe content in liver2.12.64.4-1.7-1.7-1.6-1.6-1.6-1.42.11.4-1.51.7-1.6-1.51.61.5
K content in liver1.31.24.50.91.01.01.01.00.8-2.1-1.01.2-1.01.00.9-1.1-0.9
Mg content in liver0.20.30.70.40.50.40.40.50.4-0.8-0.50.5-0.50.60.4-0.5-0.5
Mn content in liver0.10.10.70.10.10.10.10.3-0.1-0.9-0.40.30.10.20.2-0.0-0.3
Na content in liver2.62.93.21.81.81.81.71.71.8-1.4-1.71.8-1.71.71.7-1.7-1.6
Rb content in liver1.82.13.21.51.51.51.51.41.3-1.8-1.21.4-1.61.51.3-1.4-1.2
Se content in liver0.70.82.70.70.70.70.70.90.5-1.6-1.21.0-0.50.80.9-0.6-1.1
Sr content in liver4.64.04.42.12.12.02.02.02.1-1.4-1.92.1-2.02.02.1-2.0-2.0
Zn content in liver0.20.20.60.30.40.30.30.50.4-0.8-0.40.6-0.70.50.4-0.5-0.5
Bone: minimum diameter0.00.10.2-0.2-0.3-0.2-0.2-0.3-0.4-0.20.2-0.20.2-0.2-0.30.30.4
Time in familiar zone, hab. session 10.20.20.4-0.4-0.5-0.4-0.4-0.3-0.60.30.1-0.30.6-0.4-0.30.50.3
Time in novel zone, hab. session 10.40.41.00.70.70.70.70.50.7-1.0-0.40.5-0.80.70.5-0.7-0.5
Total zone transitions, hab. session 10.00.10.20.10.20.00.00.40.30.1-0.50.3-0.40.30.2-0.2-0.1
Total locomotion distance, hab. session 10.10.10.30.30.20.30.30.50.2-0.5-0.50.5-0.40.40.3-0.2-0.2
Locomotion velocity, hab. session 10.00.00.10.10.00.10.10.20.10.1-0.30.2-0.10.10.10.00.1
Time in familiar zone, hab. session 21.82.02.8-1.3-1.4-1.2-1.2-1.7-1.41.41.5-1.51.6-1.6-1.41.41.2
Time in novel zone, hab. session 22.62.83.81.61.71.41.42.01.6-1.7-1.81.7-1.91.91.7-1.6-1.5
Total zone transitions, hab. session 20.70.91.50.80.90.80.81.10.9-0.7-1.21.2-1.11.01.0-0.9-1.0
Total locomotion distance, hab. session 20.91.22.00.90.90.90.91.31.0-0.6-1.41.3-1.21.21.2-0.9-1.2
Locomotion velocity, hab. session 21.11.52.11.11.11.11.11.41.2-0.8-1.51.4-1.31.21.3-1.0-1.3
Novel to familiar place preference ratio0.91.21.81.21.31.21.21.11.3-0.6-1.01.0-1.21.21.0-1.2-0.6
Novelty place preference1.01.32.01.31.41.21.21.21.4-0.6-1.01.0-1.21.21.1-1.3-0.6
Time in novel zone, NPP test1.01.31.81.31.31.21.21.21.4-0.6-1.01.0-1.21.21.1-1.2-0.6
Total zone transitions, NPP test0.50.81.3-1.1-1.1-1.0-1.0-0.8-1.20.40.6-0.70.8-0.8-0.81.10.6
Total locomotion distance, NPP test0.10.20.4-0.5-0.6-0.5-0.5-0.3-0.60.20.1-0.10.3-0.3-0.30.50.2
Locomotion velocity, NPP test0.00.00.1-0.3-0.4-0.2-0.2-0.1-0.3-0.0-0.10.10.1-0.1-0.10.30.0
Intraocular pressure0.30.61.00.70.80.70.70.91.00.1-0.60.7-0.70.80.8-0.9-0.7
Delta distance traveled before/after self-admin0.70.81.0-1.0-0.9-0.9-0.9-0.9-0.90.80.9-0.80.8-0.9-0.90.80.8
Delta ambulatory time before/after self-admin0.50.91.3-1.1-1.0-1.1-1.1-0.8-0.91.00.9-0.80.8-0.9-0.90.80.8
Parametrial fat weight2.76.49.02.72.62.72.72.63.0-0.6-2.52.6-2.52.52.8-2.5-2.4
Pavlov. Cond. lever latency0.40.50.80.90.90.90.90.50.8-0.4-0.50.5-0.50.70.6-0.8-0.5
Pavlov. Cond. magazine entry latency2.73.44.6-2.0-2.1-2.0-2.0-1.7-2.01.71.6-1.71.7-1.8-1.72.11.5
Pavlov. Cond. change in total contacts1.01.12.20.80.90.80.81.30.9-0.8-1.31.2-1.01.01.2-0.8-1.5
Pavlov. Cond. index score2.53.24.5-2.1-2.1-2.0-2.0-1.6-2.01.51.4-1.61.7-1.8-1.62.11.3
Pavlov. Cond. latency score2.02.63.6-1.9-1.9-1.8-1.8-1.4-1.81.31.3-1.41.5-1.6-1.51.81.2
Pavlov. Cond. lever contacts1.01.32.0-1.4-1.4-1.4-1.4-0.9-1.30.80.7-0.91.0-1.1-0.91.30.7
Pavlov. Cond. magazine entry number2.83.55.32.22.22.22.21.52.1-1.9-1.41.7-1.71.81.6-2.3-1.2
Pavlov. Cond. intertrial magazine entries0.30.41.60.70.60.80.80.30.5-1.3-0.30.6-0.40.50.4-0.7-0.2
Pavlov. Cond. lever-magazine prob. diff.3.13.85.3-2.3-2.3-2.2-2.2-1.7-2.21.61.5-1.71.8-1.9-1.82.31.4
Pavlov. Cond. response bias1.41.83.0-1.7-1.7-1.7-1.7-1.0-1.61.00.9-1.11.1-1.2-1.11.70.7
Pavlov. Cond. lever latency3.04.37.92.02.02.02.01.91.8-2.8-2.02.2-2.12.01.9-2.0-1.8
Pavlov. Cond. magazine entry latency0.10.10.3-0.4-0.3-0.5-0.5-0.0-0.20.40.3-0.3-0.0-0.0-0.30.30.3
Pavlov. Cond. change in total contacts0.10.20.6-0.3-0.4-0.3-0.3-0.4-0.30.80.6-0.50.3-0.3-0.40.40.5
Pavlov. Cond. index score0.91.42.5-1.2-1.2-1.2-1.2-1.0-1.01.61.2-1.21.0-1.0-1.11.21.1
Pavlov. Cond. latency score1.11.82.7-1.4-1.4-1.4-1.4-1.2-1.21.71.3-1.41.2-1.2-1.31.41.2
Pavlov. Cond. lever contacts3.24.87.9-2.1-2.2-2.1-2.1-2.1-1.92.82.2-2.32.2-2.2-2.12.22.0
Pavlov. Cond. magazine entry number0.00.10.40.20.10.30.3-0.1-0.0-0.6-0.10.30.1-0.00.1-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.00.00.10.00.00.10.10.10.10.0-0.30.20.3-0.10.2-0.0-0.2
Pavlov. Cond. lever-magazine prob. diff.1.11.62.5-1.3-1.3-1.4-1.3-1.1-1.11.61.3-1.31.1-1.1-1.21.31.2
Pavlov. Cond. response bias1.52.04.0-1.4-1.4-1.4-1.4-1.3-1.12.01.5-1.61.4-1.4-1.31.31.3
Time in closed arm before self-admin0.10.20.90.40.40.40.40.20.2-1.0-0.40.4-0.40.40.4-0.4-0.5
Time in closed arm after self-admin3.03.44.0-2.0-1.9-1.9-1.9-1.9-1.91.41.9-1.81.9-1.8-1.81.91.7
Time in open arm before self-admin0.70.81.1-0.9-0.9-0.9-0.9-0.7-0.90.81.0-0.90.9-0.9-0.90.91.0
Time in open arm after self-admin1.01.11.81.31.01.31.30.91.1-0.7-0.90.9-0.90.91.0-0.9-0.9
Bone: periosteal estimation0.61.42.21.31.31.31.31.11.1-1.5-1.11.1-1.21.21.1-1.2-0.9
Bone: periosteal perimeter1.32.53.01.71.71.71.71.51.6-1.6-1.51.7-1.71.61.5-1.6-1.2
Bone: post-yield work0.00.10.20.30.30.20.20.40.2-0.3-0.20.3-0.30.30.2-0.2-0.0
Progressive ratio test 1 active lever presses0.40.71.41.00.71.11.10.70.5-1.2-0.60.8-0.60.70.7-0.6-0.8
Progressive ratio test 1 breakpoint0.40.71.31.00.71.01.00.70.5-1.1-0.60.8-0.70.70.8-0.7-0.8
Progressive ratio test 1 inactive lever presses2.25.96.82.52.52.52.52.42.4-2.3-2.32.6-2.42.42.5-2.4-2.4
Progressive ratio test 2 active lever presses0.71.01.61.21.01.21.21.00.8-1.3-1.01.0-0.70.91.0-0.8-0.9
Progressive ratio test 2 breakpoint0.70.91.21.10.91.11.10.90.7-1.1-1.00.9-0.70.80.9-0.7-0.8
Progressive ratio test 2 inactive lever presses0.61.92.51.51.31.61.61.31.2-1.2-1.41.5-1.21.31.4-1.2-1.3
Incentive Sensitization - Responses0.10.30.50.70.60.70.70.60.6-0.5-0.70.6-0.40.50.6-0.5-0.4
Incentive Sensitization - Breakpoint0.10.20.40.60.50.60.60.50.5-0.4-0.60.5-0.30.40.5-0.4-0.3
Sum of active levers in priming session hrs 5-60.30.30.60.10.40.0-0.00.60.5-0.3-0.70.6-0.60.50.6-0.6-0.8
Progressive ratio0.10.20.6-0.4-0.4-0.3-0.3-0.8-0.5-0.20.5-0.40.7-0.6-0.50.40.4
Food seeking constrained by brief footshock2.53.16.01.71.71.81.71.71.6-2.5-1.71.8-1.61.71.6-1.9-1.4
Seeking ratio, punishment vs. effort0.51.11.70.90.90.80.81.31.0-1.0-1.11.2-1.21.21.1-1.1-1.0
Retroperitoneal fat weight0.62.53.51.61.61.61.61.61.9-0.1-1.51.7-1.51.61.8-1.6-1.6
Reaction time number correct0.00.10.20.10.20.10.10.40.30.3-0.20.2-0.30.30.3-0.1-0.2
Reaction time mean minus median0.21.53.4-1.2-1.1-1.2-1.2-1.1-0.71.81.4-1.31.2-1.1-1.20.91.3
Reaction time mean minus median AUC0.21.31.9-1.2-1.0-1.2-1.2-1.1-0.81.41.3-1.31.1-1.0-1.21.01.3
Reaction time num false alarms0.10.20.9-0.10.0-0.1-0.10.3-0.2-0.8-0.70.5-0.10.20.40.0-0.9
Reaction time num false alarms AUC0.10.20.8-0.3-0.2-0.3-0.30.1-0.4-0.9-0.50.30.1-0.00.20.2-0.8
Reaction time trials correct on left0.00.10.20.10.20.10.10.40.30.3-0.20.2-0.30.30.3-0.1-0.2
Reaction time trials on left0.00.00.10.10.10.00.00.40.20.3-0.20.1-0.20.20.2-0.0-0.2
Reaction time mean0.40.91.3-1.0-0.9-1.0-1.0-1.1-0.61.21.1-1.01.0-1.0-0.90.70.9
Reaction time mean AUC0.61.52.0-1.3-1.1-1.2-1.2-1.4-0.91.31.4-1.21.3-1.2-1.21.01.2
Median of all reaction times0.30.50.9-0.8-0.7-0.7-0.7-1.0-0.50.80.9-0.70.8-0.8-0.70.50.7
Reaction time omissions1.42.22.8-1.6-1.5-1.6-1.6-1.7-1.41.51.5-1.51.5-1.5-1.41.41.0
Reaction time false alarm rate0.10.21.0-0.3-0.2-0.3-0.30.0-0.4-1.0-0.40.30.2-0.00.10.2-0.7
Reaction time premature initiation rate2.74.25.0-2.2-2.2-2.2-2.2-1.9-2.11.42.0-2.02.0-2.0-2.12.12.0
Reaction time premature initiations0.82.33.0-1.7-1.7-1.7-1.7-1.3-1.51.21.4-1.51.4-1.4-1.51.61.5
Std. dev. reaction times0.51.53.1-1.2-1.1-1.2-1.2-1.3-0.81.81.4-1.31.2-1.2-1.21.01.2
Reaction time trials completed0.00.00.10.10.10.00.00.40.20.3-0.20.1-0.20.20.2-0.0-0.2
Reaction time trials AUC0.00.10.20.20.20.10.20.50.30.1-0.30.2-0.30.30.3-0.1-0.3
Run reversals in cocaine runway, females0.80.91.2-1.1-1.1-1.1-1.1-1.0-0.91.10.8-0.81.0-1.0-0.81.00.6
Run reversals in cocaine runway, males0.40.40.80.70.90.60.60.70.8-0.7-0.40.6-0.60.70.6-0.8-0.3
Latency to leave start box in cocaine runway0.00.10.30.10.20.10.1-0.2-0.1-0.4-0.20.20.0-0.00.2-0.1-0.5
Latency to leave start box in cocaine runway, F0.70.81.60.90.90.80.80.60.6-1.3-1.11.0-0.90.80.8-0.9-1.0
Latency to leave start box in cocaine runway, M0.70.71.3-0.7-0.8-0.6-0.6-1.0-0.80.81.0-0.81.1-1.0-0.70.90.4
Std. dev. time between licks in bursts0.00.00.1-0.2-0.1-0.2-0.2-0.00.00.4-0.1-0.0-0.00.00.10.1-0.1
Total sessions with >9 infusions0.70.91.9-0.6-0.9-0.6-0.6-1.0-1.4-0.11.1-1.11.1-1.0-1.11.11.1
Short access day 1 total inactive lever presses2.44.76.62.32.32.32.32.12.1-2.6-2.02.1-2.02.02.0-2.1-2.0
Short access day 10 total inactive lever presses0.00.10.20.30.40.30.30.40.5-0.1-0.40.4-0.30.30.4-0.2-0.4
Short access day 1 total infusions0.30.71.0-0.6-0.7-0.6-0.6-0.9-1.0-0.21.0-0.90.9-0.8-1.00.91.0
Short access day 10 total infusions0.20.30.8-0.1-0.5-0.0-0.0-0.7-0.9-0.50.7-0.60.7-0.6-0.60.70.7
Short access total infusions0.10.21.50.50.20.50.5-0.1-0.4-1.20.1-0.10.2-0.1-0.10.10.1
Short access day 1 locomotion0.71.22.4-1.0-1.1-0.9-0.9-1.1-1.6-0.11.2-1.11.0-1.0-1.31.01.2
Short access day 10 total locomotion0.31.21.9-0.9-1.1-0.8-0.8-1.3-1.30.11.4-1.21.1-1.1-1.31.21.3
Short access total locomotion1.01.62.4-1.0-1.2-1.0-1.0-1.4-1.60.21.5-1.41.3-1.3-1.51.31.4
One hour access (0.3 mA shock)1.41.72.61.61.31.61.61.20.9-1.6-1.31.2-0.91.11.2-1.0-1.2
Compulsive drug intake1.52.32.8-1.4-1.5-1.4-1.4-1.6-1.51.31.4-1.51.7-1.6-1.51.61.5
One hour access (shock baseline)0.82.13.31.81.41.81.81.41.3-1.7-1.31.4-1.21.31.4-1.2-1.3
Social response proportion1.41.82.61.11.41.11.11.41.6-0.3-1.51.5-1.61.51.5-1.6-1.0
Social responses2.22.83.51.61.71.51.51.81.9-0.5-1.81.8-1.91.81.8-1.8-1.8
Social time0.10.20.40.20.30.20.20.40.50.6-0.20.4-0.50.40.5-0.5-0.6
Soleus weight0.61.95.41.41.41.61.51.01.0-2.3-1.11.3-1.21.21.1-1.4-1.0
Bone: stiffness0.00.10.2-0.2-0.2-0.2-0.2-0.2-0.20.20.3-0.30.2-0.2-0.30.20.4
Tibialis anterior weight1.24.34.82.22.12.12.12.21.9-1.9-2.12.0-2.22.12.1-1.9-2.0
Time to tail flick, vehicle, before self-admin0.00.00.1-0.0-0.10.00.0-0.1-0.0-0.2-0.10.20.00.00.10.1-0.1
Time to tail flick, vehicle, after self-admin0.10.20.4-0.6-0.7-0.5-0.5-0.5-0.60.50.5-0.30.5-0.5-0.40.50.1
Time to tail flick, test, before self-admin0.00.10.10.0-0.10.00.0-0.3-0.1-0.30.3-0.30.2-0.2-0.30.20.3
Time to tail flick, test, after self-admin2.72.83.51.71.61.71.71.71.5-1.9-1.71.8-1.61.61.7-1.6-1.8
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.3-0.4-0.2-0.2-0.5-0.50.40.6-0.50.4-0.5-0.50.40.6
Delta time to tail flick, test, before/after SA1.11.31.81.01.01.01.01.31.1-0.6-1.31.3-1.21.21.3-1.2-1.3
Tibia length0.20.61.3-0.6-0.8-0.4-0.4-1.1-1.0-0.70.9-0.70.6-0.8-0.80.60.6
Ambulatory time before self-admin0.20.72.80.90.80.80.80.70.7-1.7-0.70.6-0.60.70.6-0.6-0.7
Ambulatory time after self-admin0.00.00.5-0.0-0.0-0.0-0.1-0.1-0.1-0.70.1-0.00.1-0.0-0.10.1-0.1
Bone: tissue strength0.10.10.20.40.40.30.30.10.3-0.10.0-0.1-0.20.20.1-0.3-0.0
Total heroin consumption0.00.00.1-0.1-0.2-0.1-0.1-0.1-0.40.00.3-0.10.2-0.2-0.00.2-0.2
Bone: trabecular number0.00.10.2-0.2-0.2-0.3-0.3-0.2-0.4-0.30.3-0.30.1-0.2-0.30.30.2
Bone: trabecular spacing1.11.61.91.31.31.31.31.31.3-0.9-1.21.3-1.31.21.3-1.4-1.1
Bone: trabecular thickness1.52.02.7-1.7-1.6-1.6-1.6-1.4-1.60.81.3-1.31.3-1.4-1.41.61.2
Bone: trabecular tissue density0.10.21.4-0.4-0.4-0.4-0.4-0.3-0.21.20.4-0.50.4-0.3-0.40.40.6
Water consumed over 24 hours0.91.82.61.31.51.21.21.61.5-0.5-1.41.3-1.51.51.4-1.3-1.2
Number of responses in last shaping day0.20.20.3-0.6-0.5-0.6-0.6-0.5-0.50.40.3-0.40.5-0.5-0.50.40.4