Hub : Genes

Xbp1

X-box binding protein 1

chr14:84604623–84609707 (+)

Xbp1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Xbp1 0.31 0.13 0.0e+00 0.33 0.33 0.34 0.34 5.2e-27 1.5e-27 6.9e-28 2.3e-28
2 LHb mRNA stability Xbp1 0.42 0.19 4.2e-09 0.3 0.29 0.2 0.32 7.8e-08 1.5e-07 1.3e-05 2.6e-08
3 OFC mRNA stability Xbp1 0.51 0.16 2.6e-12 0.35 0.36 0.34 0.37 2.8e-09 2.1e-09 6.6e-09 1.2e-09
4 RMTg mRNA stability Xbp1 0.47 0.18 2.8e-08 0.32 0.31 0.34 0.34 4.0e-09 5.9e-09 6.3e-10 8.0e-10
5 NAcc mRNA stability Xbp1 0.37 0.14 0.0e+00 0.36 0.37 0.37 0.37 2.4e-57 1.5e-58 7.0e-59 6.2e-59
6 IL mRNA stability Xbp1 0.52 0.17 1.3e-12 0.37 0.39 0.29 0.39 9.3e-10 2.3e-10 1.3e-07 2.5e-10
7 BLA mRNA stability Xbp1 0.25 0.13 6.3e-13 0.17 0.22 0.21 0.19 1.4e-09 6.3e-12 3.7e-11 2.3e-10
8 PL mRNA stability Xbp1 0.4 0.15 0.0e+00 0.43 0.45 0.44 0.45 1.5e-51 5.9e-54 1.3e-52 1.2e-54
9 Eye mRNA stability Xbp1 0.38 0.18 1.4e-03 0.06 0.17 0.1 0.15 5.2e-02 1.6e-03 1.3e-02 3.0e-03
10 IC mRNA stability Xbp1 0.33 0.14 0.0e+00 0.37 0.39 0.38 0.39 2.2e-16 2.1e-17 4.7e-17 1.0e-17
11 Adipose mRNA stability Xbp1 0.14 0.07 0.0e+00 0.17 0.16 0.15 0.16 1.2e-18 1.1e-17 3.6e-16 1.6e-17
12 Brain mRNA stability Xbp1 0.54 0.14 0.0e+00 0.55 0.54 0.55 0.55 1.6e-61 3.4e-60 2.4e-61 3.5e-61
13 pVTA mRNA stability Xbp1 0.87 0.09 0.0e+00 0.49 0.48 0.47 0.48 3.1e-44 3.2e-43 1.8e-42 9.6e-44
14 Liver mRNA stability Xbp1 0.15 0.07 0.0e+00 0.18 0.18 0.18 0.18 5.5e-20 1.1e-19 1.4e-19 6.0e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.5-0.5-0.7-0.7-0.0-0.2-0.3-0.4-0.6-0.4-0.3-0.3-0.2-0.5-0.3
Area under the delay curve3.23.74.92.02.22.22.01.81.82.11.91.91.91.81.91.81.8
BMI with tail0.00.10.40.20.20.2-0.10.20.20.50.40.50.20.20.60.10.6
BMI without tail0.31.02.10.91.01.01.50.80.91.00.80.90.90.91.00.81.1
Body weight1.35.86.62.52.52.52.52.32.32.52.42.42.32.32.62.22.5
Weight adjusted by age0.30.41.30.60.80.81.10.60.70.60.30.50.70.70.40.40.4
Bone surface0.20.30.60.50.20.20.50.80.60.50.40.50.60.60.70.30.4
Bone volume0.10.20.50.40.10.10.50.70.50.40.20.40.50.50.70.20.4
Breakpoint value in progressive ratio session0.50.60.70.80.80.80.90.80.80.80.60.80.70.70.70.70.8
Number of licking bursts2.13.43.81.91.81.81.91.81.91.91.81.81.91.91.91.91.8
Context. condit. distance diff. score3.74.55.4-2.3-2.3-2.3-2.1-2.1-2.1-2.2-2.2-2.1-2.1-2.1-1.9-2.2-1.8
Locomotion velocity, session 10.10.20.90.30.30.3-1.00.20.10.20.70.20.30.30.20.4-0.3
Locomotion distance, session 10.81.01.5-1.2-1.1-1.1-0.5-1.1-1.2-0.8-1.2-1.0-0.9-0.8-0.9-1.0-0.9
Locomotion velocity, session 20.10.11.00.20.10.1-1.00.30.20.10.50.30.30.20.40.10.2
Locomotion distance, session 21.72.33.8-1.8-1.7-1.7-2.0-1.4-1.7-1.3-1.4-1.3-1.4-1.4-1.1-1.7-1.0
Locomotion velocity, session 32.93.34.3-2.0-2.1-2.1-1.6-1.7-1.8-1.8-1.9-1.8-1.8-1.9-1.3-2.0-1.6
Locomotion distance, session 30.20.21.1-0.0-0.1-0.10.00.60.20.4-0.00.40.2-0.01.1-0.20.8
Stereotopy head waving bouts, day 31.01.21.5-1.2-1.2-1.2-0.8-1.1-1.1-1.0-1.2-1.0-1.1-0.9-1.1-1.1-0.7
Stereotopy head waving duration, day 32.32.73.5-1.7-1.6-1.6-1.6-1.9-1.7-1.7-1.5-1.7-1.7-1.6-1.9-1.6-1.6
Locomotion velocity, session 70.20.20.50.40.40.40.20.60.50.50.40.50.50.50.70.20.5
Locomotion distance, session 70.20.20.9-0.5-0.6-0.6-1.0-0.2-0.5-0.4-0.5-0.3-0.3-0.3-0.1-0.6-0.2
Stereotopy head waving bouts, day 70.00.00.20.0-0.1-0.10.0-0.2-0.0-0.3-0.0-0.2-0.1-0.1-0.40.0-0.3
Stereotopy head waving duration, day 70.00.00.1-0.1-0.2-0.20.2-0.2-0.1-0.2-0.1-0.3-0.1-0.1-0.30.0-0.3
Locomotion velocity, session 81.21.43.8-1.2-1.3-1.3-2.0-1.0-1.1-1.2-1.0-1.0-1.1-1.1-0.7-1.3-1.0
Locomotion distance, session 87.811.313.0-3.6-3.6-3.6-3.5-3.3-3.4-3.4-3.4-3.2-3.4-3.3-2.9-3.5-2.9
Degree of sensitization distance1.71.82.9-1.1-1.1-1.1-1.7-1.4-1.3-1.5-1.0-1.4-1.2-1.0-1.6-1.0-1.7
Degree of sensitization stereotypy0.10.10.30.50.40.40.50.20.40.20.40.20.30.20.10.60.1
Conditioned locomotion1.41.62.5-1.6-1.4-1.4-0.7-1.3-1.4-1.1-1.5-1.2-1.3-1.2-1.1-1.5-1.0
Cocaine response after cond. corrected1.82.12.61.61.61.61.61.41.51.41.51.31.41.51.11.51.1
Cocaine response after cond. not corrected1.92.24.11.61.71.72.01.41.51.41.41.31.41.51.11.61.2
Cocaine response before conditioning0.40.50.7-0.8-0.6-0.7-0.2-0.8-0.7-0.7-0.8-0.8-0.8-0.7-0.8-0.8-0.7
Saline control response0.50.71.7-0.8-0.9-0.9-1.3-0.6-0.8-0.7-0.7-0.6-0.7-1.0-0.5-0.9-0.5
Bone: connectivity density0.20.30.6-0.6-0.8-0.8-0.3-0.4-0.5-0.6-0.7-0.6-0.5-0.4-0.5-0.7-0.5
Bone: cortical apparent density0.71.01.51.10.90.91.11.01.00.91.00.91.11.21.01.20.9
Bone: cortical area2.33.54.51.91.91.82.11.91.81.91.71.81.92.02.01.81.5
Bone: cortical porosity0.00.00.10.20.10.10.30.20.20.10.20.10.1-0.00.10.20.1
Bone: cortical porosity0.20.20.3-0.4-0.4-0.4-0.1-0.5-0.4-0.4-0.4-0.5-0.5-0.5-0.5-0.3-0.4
Bone: cortical thickness1.32.24.31.41.31.32.11.51.51.61.21.41.51.61.81.31.3
Bone: cortical thickness1.01.11.8-1.2-1.1-1.2-0.2-1.0-1.1-1.0-1.3-1.1-1.1-0.9-1.0-1.1-1.1
Bone: cortical tissue density0.81.11.61.21.01.01.11.11.10.91.11.01.11.31.11.20.9
Condit. Reinf. active minus inactive responses1.01.12.11.00.90.9-0.11.21.01.11.21.31.01.11.20.81.5
Condit. Reinf. active-inactive response ratio0.20.21.70.30.30.4-1.30.30.30.10.60.40.30.40.20.10.5
Condit. Reinf. active responses0.50.61.10.60.50.5-0.11.00.70.90.80.90.70.71.00.51.1
Condit. Reinf. inactive responses0.10.20.60.20.00.00.70.50.30.50.00.40.30.20.70.20.5
Incentive salience index mean1.21.52.91.11.01.00.41.41.11.41.21.41.21.21.40.91.7
Condit. Reinf. lever presses0.20.30.70.30.30.30.60.70.30.80.30.70.50.50.80.20.8
Condit. Reinf. active minus inactive responses0.50.60.8-0.8-0.9-0.9-0.9-0.7-0.8-0.7-0.8-0.7-0.8-0.9-0.8-0.9-0.7
Condit. Reinf. active-inactive response ratio0.00.00.1-0.2-0.2-0.2-0.3-0.1-0.20.0-0.1-0.0-0.1-0.0-0.1-0.20.1
Condit. Reinf. active responses0.60.91.3-1.0-1.0-1.0-1.1-0.8-1.0-0.9-0.8-0.9-0.9-1.0-1.0-1.0-0.9
Condit. Reinf. inactive responses0.71.01.6-0.9-0.9-0.9-1.3-0.9-0.9-1.0-0.8-1.0-1.0-1.0-1.1-0.9-1.1
Condit. Reinf. lever presses0.50.71.0-0.9-1.0-1.0-0.8-0.7-0.9-0.8-0.9-0.8-0.8-0.9-0.9-1.0-0.7
Condit. Reinf. lever reinforcers received0.50.71.0-0.8-0.9-0.9-1.0-0.7-0.9-0.7-0.7-0.7-0.8-0.8-0.9-0.8-0.7
Conditioned reinforcement - actives0.20.30.80.60.80.80.90.50.60.50.40.50.50.40.50.40.4
Conditioned reinforcement - inactives0.71.01.41.11.21.20.81.11.01.01.01.01.00.91.01.00.8
Conditioned locomotion0.91.22.01.01.31.41.41.11.11.00.81.01.01.01.01.11.0
Patch foraging indifference point 0 sec1.73.24.41.91.81.81.91.82.01.51.51.71.61.71.91.62.1
Patch foraging indifference point AUC0.10.10.20.40.20.30.00.40.40.20.40.30.30.30.20.30.2
Delay disc. indifference point, 0s delay1.11.22.41.21.21.21.50.91.11.01.01.01.11.01.01.00.8
Delay disc. indifference point, 16s delay2.32.63.81.62.02.01.21.51.51.71.71.71.61.51.61.41.5
Delay disc. indifference point, 2s delay1.21.33.61.11.21.21.90.91.11.30.81.11.11.10.91.01.2
Delay disc. indifference point, 24s delay1.41.62.11.21.31.30.91.21.11.41.31.31.31.31.21.31.4
Delay disc. indifference point, 4s delay2.93.04.61.81.91.92.11.61.61.81.51.71.71.71.61.71.7
Delay disc. indifference point, 8s delay1.01.21.71.11.31.30.91.00.91.21.11.11.11.01.11.00.9
Indifference point function ln k0.00.00.1-0.3-0.3-0.40.2-0.1-0.20.0-0.3-0.1-0.1-0.10.1-0.1-0.1
Indifference point function log k0.00.00.1-0.3-0.3-0.40.2-0.1-0.20.0-0.3-0.1-0.1-0.10.1-0.1-0.1
Patch foraging total patch changes 0 sec1.73.34.71.91.81.81.81.82.11.61.61.81.71.71.91.62.2
Patch foraging total patch changes 12 sec1.21.62.11.41.31.41.31.21.41.01.11.21.11.21.21.21.4
Patch foraging total patch changes 18 sec1.82.73.71.91.81.80.81.71.81.41.91.71.61.51.61.71.7
Patch foraging total patch changes 24 sec0.61.11.8-1.0-0.8-0.8-1.3-1.1-0.9-1.3-1.0-1.0-1.2-1.2-1.0-1.2-0.5
Patch foraging total patch changes 6 sec2.03.14.61.81.61.61.41.91.91.61.61.81.71.72.01.62.2
Patch foraging time to switch 0 sec0.30.71.1-0.9-0.5-0.5-0.5-1.0-0.9-0.8-0.8-0.9-0.9-0.8-1.0-0.7-0.9
Patch foraging water rate 0 sec1.43.04.01.91.61.61.21.91.91.71.71.81.81.62.01.62.0
Patch foraging water rate 12 sec0.00.10.30.20.00.0-0.10.30.30.30.10.30.30.20.5-0.00.4
Patch foraging water rate 18 sec0.20.20.5-0.5-0.3-0.30.7-0.7-0.5-0.3-0.7-0.5-0.5-0.4-0.4-0.5-0.2
Patch foraging water rate 24 sec0.10.10.20.30.30.3-0.30.30.10.30.40.30.30.40.30.20.2
Patch foraging water rate 6 sec0.30.40.60.60.60.60.80.60.50.70.50.60.70.70.70.40.5
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.30.10.10.0-0.5-0.5-0.2-0.2-0.3-0.3-0.4-0.6-0.2-0.4
Distance traveled before self-admin0.10.21.10.40.40.41.10.30.60.20.30.20.30.20.30.10.3
Distance traveled after self-admin0.10.10.8-0.1-0.1-0.10.9-0.00.1-0.0-0.3-0.1-0.1-0.1-0.1-0.10.2
Extensor digitorum longus weight3.313.014.33.73.53.53.73.83.73.63.33.53.73.73.63.53.5
Bone: elastic displacement0.50.60.8-0.7-0.8-0.8-0.1-0.8-0.7-0.9-0.8-0.9-0.9-0.8-0.7-0.6-0.7
Bone: elastic work0.10.11.00.10.00.01.0-0.10.10.0-0.1-0.0-0.10.20.10.20.3
Bone: endosteal estimation0.00.10.20.40.40.40.50.10.30.20.20.20.30.2-0.00.40.2
Bone: endosteal perimeter0.51.11.51.21.21.21.01.00.91.11.11.01.11.10.81.20.7
Epididymis fat weight0.31.11.41.00.80.81.11.21.01.11.01.01.11.11.10.91.1
Delta time in closed arm before/after self-admin10.39.610.7-3.2-3.0-3.1-2.8-3.2-3.2-3.1-2.9-3.1-3.1-3.2-3.3-3.1-3.3
Delta time in open arm before/after self-admin8.08.09.63.03.13.12.62.72.92.73.02.82.72.62.82.62.7
Diff in mean of infusions in LGA sessions0.10.10.2-0.3-0.2-0.2-0.1-0.5-0.4-0.2-0.3-0.3-0.3-0.4-0.4-0.4-0.2
Delay discount exponential model param3.23.64.6-1.9-2.1-2.1-1.9-1.8-1.8-2.0-1.8-1.9-1.9-1.8-1.8-1.8-1.7
Extinction: sum of active levers before priming0.10.10.30.30.20.2-0.20.50.30.40.50.40.30.30.30.30.5
Active lever presses in extinction session 60.10.10.3-0.4-0.1-0.20.2-0.3-0.3-0.3-0.3-0.4-0.4-0.5-0.5-0.4-0.5
Bone: final force0.20.40.60.60.60.60.70.50.70.50.40.60.50.60.70.50.8
Bone: final moment0.30.60.80.70.70.70.90.70.80.70.60.70.70.70.80.60.9
Food consumed during 24 hour testing period2.12.83.91.81.41.50.82.01.71.71.81.81.92.01.71.61.7
Glucose21.133.343.66.35.96.02.26.25.95.56.66.06.06.05.85.85.3
Heart weight0.20.40.90.60.40.4-0.50.70.60.50.70.70.60.50.80.61.0
Delay discount hyperbolic model param3.23.54.5-1.9-2.1-2.1-2.0-1.7-1.8-2.0-1.8-1.9-1.9-1.8-1.8-1.8-1.8
Intermittent access intake day 1-15 change0.71.52.01.21.11.10.61.41.21.21.41.31.21.21.41.21.3
Intermittent access intake escalation0.61.21.91.10.91.00.41.31.11.11.31.21.11.11.41.11.2
Intermittent access intake escalation 20.30.40.80.60.50.50.20.70.60.50.70.70.60.60.90.60.7
Intermitt. access day 1 inactive lever presses0.10.20.4-0.3-0.4-0.4-0.6-0.4-0.5-0.4-0.2-0.4-0.4-0.4-0.6-0.4-0.5
Intermitt. access day 15 inactive lever presses1.42.93.51.71.61.60.51.81.61.81.81.81.81.91.71.81.8
Intermitt. access escalation Index0.10.20.50.30.10.1-0.70.60.30.30.70.50.30.40.50.40.6
Intermittent access day 1 total infusions0.20.21.40.40.80.81.20.10.40.3-0.10.20.30.20.10.20.1
Intermittent access day 15 total infusions1.82.73.61.71.91.91.71.71.71.61.41.61.61.51.71.41.6
Intermittent access terminal intake (last 3 days)1.11.52.71.21.61.61.61.11.31.00.91.11.00.91.20.91.1
Intermittent access total infusions1.21.42.61.21.51.51.61.11.21.10.81.11.00.91.10.91.1
Intermittent access day 1 locomotion0.10.10.3-0.30.10.10.4-0.4-0.3-0.3-0.6-0.4-0.3-0.3-0.4-0.3-0.5
Intermittent access day 15 total locomotion0.81.42.11.11.51.51.41.11.21.21.11.11.11.01.11.11.0
Intermittent access total locomotion1.11.32.11.11.41.41.41.11.11.20.91.11.00.91.20.91.1
Intermittent access standard deviation0.30.60.9-0.7-0.7-0.7-0.4-0.7-0.6-0.9-0.9-0.9-0.7-0.7-0.9-0.8-0.8
Left kidney weight0.00.20.90.40.40.30.9-0.10.10.30.30.10.20.40.20.50.3
Right kidney weight0.00.21.2-0.3-0.2-0.31.1-0.5-0.3-0.2-0.5-0.4-0.3-0.20.0-0.2-0.0
Cocaine induced anxiety2.84.05.52.01.81.81.62.31.92.01.92.02.02.12.41.92.1
Post-drug Anxiety2.93.14.11.81.51.51.12.01.61.81.81.81.91.92.01.81.9
Baseline Anxiety0.10.20.5-0.3-0.3-0.3-0.7-0.4-0.5-0.3-0.0-0.3-0.2-0.2-0.7-0.2-0.4
Tail length2.59.614.03.13.03.03.73.03.13.12.72.93.13.13.23.03.2
Length with tail2.39.813.03.23.13.13.63.13.13.12.83.03.13.13.23.03.1
Length without tail0.20.81.20.80.70.70.80.90.91.00.70.90.90.81.10.71.1
LgA early post infusion interval0.81.02.11.21.41.31.40.81.00.91.00.80.90.90.70.90.4
LgA late post infusion interval0.10.10.60.20.80.8-0.3-0.10.20.10.40.20.0-0.10.3-0.1-0.0
LgA early loading2.64.85.9-2.2-2.4-2.4-2.0-2.2-2.2-2.2-2.1-2.2-2.1-2.1-2.1-2.1-2.3
LgA late loading0.40.81.4-1.1-1.2-1.2-0.4-0.9-0.9-0.9-1.2-0.9-0.9-0.8-0.7-0.8-0.6
LgA early average infusions2.32.94.0-1.8-1.8-1.8-2.0-1.7-1.7-1.7-1.6-1.6-1.6-1.6-1.5-1.6-1.6
LgA late average infusions0.30.50.8-0.8-0.9-0.9-0.6-0.7-0.7-0.6-0.8-0.6-0.6-0.7-0.6-0.6-0.3
LgA early timeout0.60.62.6-0.8-1.0-1.0-1.6-0.5-0.8-0.7-0.5-0.6-0.6-0.5-0.5-0.5-0.7
LgA late timeout0.00.10.2-0.1-0.5-0.5-0.30.2-0.20.1-0.10.00.00.10.10.10.3
LgA early titration0.70.92.3-1.0-1.2-1.1-1.5-0.8-1.0-1.0-0.8-0.9-0.8-0.8-0.6-0.8-0.9
LgA late titration0.10.10.50.10.00.0-0.10.30.10.40.20.40.20.30.30.20.7
LgA total infusion1.21.72.3-1.4-1.4-1.4-1.5-1.3-1.3-1.3-1.3-1.2-1.3-1.3-1.1-1.3-1.0
Times rat made contact with spout0.20.30.80.60.20.3-0.90.70.60.10.70.50.50.60.60.30.1
Lifetime Intake1.01.22.91.11.51.51.70.91.10.90.60.90.90.70.90.70.9
Liver weight, left0.40.71.0-0.9-0.8-0.90.0-0.9-0.9-0.8-0.9-1.0-0.8-0.8-0.8-0.7-1.0
Liver weight, right1.32.22.8-1.7-1.4-1.4-0.6-1.6-1.5-1.4-1.6-1.6-1.4-1.4-1.5-1.6-1.7
Locomotor activity0.81.32.01.31.41.40.71.01.31.01.31.11.11.30.81.11.0
Locomotor testing distance0.30.51.60.70.80.81.30.50.80.60.50.50.60.90.40.80.6
Locomotor testing rearing1.63.24.21.91.81.81.71.81.91.61.71.71.82.01.61.81.7
Locomotion in novel chamber3.44.45.3-2.1-2.0-2.0-1.6-2.1-2.0-2.2-2.3-2.2-2.1-2.1-2.0-2.3-2.3
Locomotion in novel chamber post-restriction2.13.46.3-2.0-1.8-1.8-2.5-1.9-2.0-1.7-1.5-1.7-1.8-1.7-1.7-1.7-1.9
Fecal boli incidents, locomotor time 10.10.10.2-0.4-0.3-0.4-0.3-0.3-0.4-0.2-0.3-0.3-0.2-0.1-0.4-0.1-0.4
Change in fecal boli incidents, locomotor task0.30.30.60.60.50.5-0.40.60.50.40.80.50.60.60.60.50.4
Time >=10cm from walls, locomotor time 10.10.10.60.00.00.0-0.20.0-0.1-0.10.2-0.10.10.2-0.30.2-0.7
Bouts of movement, locomotor time 10.60.61.00.90.90.90.01.00.90.70.80.90.80.80.80.80.7
Total resting periods, locomotor time 10.20.20.30.40.40.5-0.40.50.40.30.40.50.40.40.40.40.3
Rest time, locomotor task time 10.10.10.30.20.00.1-0.20.50.20.30.30.20.30.40.20.3-0.1
Distance moved, locomotor task time 10.20.30.60.50.60.60.80.20.50.40.40.40.40.40.40.50.7
Vertical activity count, locomotor time 10.00.10.30.30.50.50.6-0.00.40.20.20.20.20.20.20.20.4
Time >=10cm from walls, locomotor time 20.20.31.5-0.30.10.0-0.2-0.7-0.5-0.4-0.3-0.5-0.3-0.3-0.8-0.3-1.2
Bouts of movement, locomotor time 20.00.00.3-0.20.20.10.0-0.1-0.30.3-0.10.1-0.1-0.2-0.1-0.10.5
Total resting periods, locomotor time 20.00.10.5-0.00.20.2-0.10.1-0.10.40.10.30.0-0.0-0.0-0.00.7
Rest time, locomotor task time 20.10.10.3-0.3-0.4-0.4-0.50.0-0.2-0.2-0.2-0.1-0.1-0.1-0.3-0.1-0.0
Distance moved, locomotor task time 20.10.10.3-0.2-0.2-0.2-0.1-0.3-0.2-0.3-0.2-0.3-0.2-0.2-0.3-0.1-0.6
Vertical activity count, locomotor time 20.00.10.5-0.10.10.00.3-0.2-0.1-0.1-0.2-0.2-0.1-0.1-0.1-0.1-0.7
Light reinforcement 10.10.20.80.30.30.30.90.40.30.30.00.20.30.30.50.30.4
Light reinforcement 20.10.11.00.30.50.51.0-0.10.00.30.10.10.20.20.10.2-0.0
Bone: marrow area0.00.00.10.20.30.30.3-0.00.20.10.10.10.10.1-0.10.20.0
Bone: maximum diameter4.58.59.73.13.03.02.23.12.93.03.13.03.03.02.82.92.6
Bone: maximum force0.10.20.70.40.40.40.80.40.50.40.20.40.50.50.50.30.5
Bone: maximum moment0.20.41.20.60.60.61.10.60.70.60.40.60.60.70.70.50.7
Mean time between licks in bursts0.41.01.61.11.01.0-0.00.90.91.01.31.11.11.11.01.00.8
Mean num. licks in bursts1.21.95.0-1.3-1.4-1.3-2.2-1.1-1.3-1.5-1.1-1.2-1.3-1.3-1.2-1.4-1.4
Cd content in liver0.70.70.90.90.80.80.40.90.90.80.90.90.90.90.80.81.0
Co content in liver0.20.31.10.50.20.20.70.50.50.40.40.50.40.50.40.61.1
Cu content in liver0.30.30.60.60.40.40.00.60.60.50.70.50.60.70.50.60.5
Fe content in liver2.12.64.4-1.7-1.6-1.6-2.1-1.6-1.8-1.5-1.4-1.5-1.6-1.7-1.4-1.6-1.5
K content in liver1.31.24.51.01.00.92.11.01.01.20.80.91.01.01.01.10.9
Mg content in liver0.30.30.70.50.40.40.80.50.50.50.40.40.60.50.50.50.5
Mn content in liver0.10.10.70.10.10.10.90.30.20.3-0.10.20.2-0.10.40.00.3
Na content in liver2.72.93.11.81.81.71.41.71.61.81.81.71.71.71.71.71.6
Rb content in liver1.82.13.21.51.51.41.81.41.51.41.31.31.51.61.21.41.2
Se content in liver0.70.82.70.70.70.71.60.90.91.00.50.90.80.51.20.61.1
Sr content in liver4.63.94.42.12.02.01.42.01.92.12.12.12.02.01.92.02.0
Zn content in liver0.20.20.60.40.30.30.80.50.30.60.40.40.50.70.40.50.5
Bone: minimum diameter0.00.10.2-0.3-0.2-0.20.2-0.3-0.3-0.2-0.4-0.3-0.2-0.2-0.2-0.3-0.4
Time in familiar zone, hab. session 10.20.20.4-0.5-0.4-0.4-0.3-0.3-0.4-0.3-0.6-0.3-0.4-0.6-0.1-0.5-0.3
Time in novel zone, hab. session 10.40.41.00.70.70.71.00.50.70.50.70.50.70.80.40.70.5
Total zone transitions, hab. session 10.00.10.20.20.00.0-0.10.40.10.30.30.20.30.40.50.20.1
Total locomotion distance, hab. session 10.10.10.30.20.30.30.50.50.20.50.20.30.40.40.50.20.2
Locomotion velocity, hab. session 10.00.00.10.00.10.1-0.10.2-0.10.20.10.10.10.10.3-0.0-0.1
Time in familiar zone, hab. session 21.92.02.7-1.4-1.2-1.2-1.4-1.7-1.5-1.5-1.4-1.4-1.6-1.6-1.5-1.4-1.2
Time in novel zone, hab. session 22.82.93.81.71.41.41.72.01.81.71.61.71.91.91.81.61.5
Total zone transitions, hab. session 20.70.91.50.80.80.80.71.10.81.20.91.01.01.11.20.91.0
Total locomotion distance, hab. session 20.91.22.00.90.90.90.61.30.81.31.01.21.21.21.40.91.2
Locomotion velocity, hab. session 21.11.42.11.11.11.10.81.40.91.41.21.31.21.31.51.01.3
Novel to familiar place preference ratio1.11.21.81.31.21.20.61.11.11.01.31.01.21.21.01.20.6
Novelty place preference1.21.32.01.41.21.20.61.21.21.01.41.11.21.21.01.30.6
Time in novel zone, NPP test1.21.31.81.31.21.20.61.21.21.01.41.11.21.21.01.20.6
Total zone transitions, NPP test0.50.81.3-1.1-1.0-1.0-0.4-0.8-1.1-0.7-1.2-0.8-0.8-0.8-0.6-1.1-0.6
Total locomotion distance, NPP test0.10.20.4-0.6-0.5-0.5-0.2-0.3-0.6-0.1-0.6-0.3-0.3-0.3-0.1-0.5-0.2
Locomotion velocity, NPP test0.00.00.2-0.4-0.2-0.20.0-0.1-0.40.1-0.3-0.1-0.1-0.10.1-0.3-0.0
Intraocular pressure0.40.51.00.80.70.7-0.10.90.60.71.00.80.80.70.60.90.7
Delta distance traveled before/after self-admin0.70.81.0-0.9-0.9-0.9-0.8-0.9-1.0-0.8-0.9-0.9-0.9-0.8-0.9-0.8-0.8
Delta ambulatory time before/after self-admin0.70.91.3-1.0-1.1-1.1-1.0-0.8-1.0-0.8-0.9-0.9-0.9-0.8-0.9-0.8-0.8
Parametrial fat weight2.66.29.02.62.72.70.62.62.32.63.02.82.52.52.52.52.4
Pavlov. Cond. lever latency0.40.50.80.90.90.90.40.50.70.50.80.60.70.50.50.80.5
Pavlov. Cond. magazine entry latency2.63.44.6-2.1-2.0-2.0-1.7-1.7-1.8-1.7-2.0-1.7-1.8-1.7-1.6-2.1-1.5
Pavlov. Cond. change in total contacts1.01.12.20.90.80.80.81.31.01.20.91.21.01.01.30.81.5
Pavlov. Cond. index score2.53.14.5-2.1-2.0-2.0-1.5-1.6-1.8-1.6-2.0-1.6-1.8-1.7-1.4-2.1-1.3
Pavlov. Cond. latency score2.02.53.6-1.9-1.8-1.8-1.3-1.4-1.6-1.4-1.8-1.5-1.6-1.5-1.3-1.8-1.2
Pavlov. Cond. lever contacts1.01.22.0-1.4-1.4-1.4-0.8-0.9-1.1-0.9-1.3-0.9-1.1-1.0-0.7-1.3-0.7
Pavlov. Cond. magazine entry number2.73.45.32.22.22.21.91.51.81.72.11.61.81.71.42.31.2
Pavlov. Cond. intertrial magazine entries0.30.41.60.60.80.81.30.30.40.60.50.40.50.40.30.70.2
Pavlov. Cond. lever-magazine prob. diff.3.03.75.3-2.3-2.2-2.2-1.6-1.7-2.0-1.7-2.2-1.8-1.9-1.8-1.5-2.3-1.4
Pavlov. Cond. response bias1.41.73.0-1.7-1.7-1.7-1.0-1.0-1.3-1.1-1.6-1.1-1.2-1.1-0.9-1.7-0.7
Pavlov. Cond. lever latency3.14.27.92.02.02.02.81.92.02.21.81.92.02.12.02.01.8
Pavlov. Cond. magazine entry latency0.10.10.3-0.3-0.5-0.5-0.4-0.0-0.2-0.3-0.2-0.3-0.00.0-0.3-0.3-0.3
Pavlov. Cond. change in total contacts0.10.20.6-0.4-0.3-0.3-0.8-0.4-0.5-0.5-0.3-0.4-0.3-0.3-0.6-0.4-0.5
Pavlov. Cond. index score1.01.42.5-1.2-1.2-1.2-1.6-1.0-1.1-1.2-1.0-1.1-1.0-1.0-1.2-1.2-1.1
Pavlov. Cond. latency score1.41.82.7-1.4-1.4-1.4-1.7-1.2-1.3-1.4-1.2-1.3-1.2-1.2-1.3-1.4-1.2
Pavlov. Cond. lever contacts3.54.87.9-2.2-2.1-2.1-2.8-2.1-2.1-2.3-1.9-2.1-2.2-2.2-2.2-2.2-2.0
Pavlov. Cond. magazine entry number0.00.00.40.10.30.30.6-0.10.00.3-0.00.1-0.0-0.10.10.10.1
Pavlov. Cond. intertrial magazine entries0.00.00.10.00.10.1-0.00.10.00.20.10.2-0.1-0.30.30.00.2
Pavlov. Cond. lever-magazine prob. diff.1.21.62.5-1.3-1.4-1.3-1.6-1.1-1.2-1.3-1.1-1.2-1.1-1.1-1.3-1.3-1.2
Pavlov. Cond. response bias1.52.04.0-1.3-1.4-1.4-2.0-1.3-1.3-1.6-1.1-1.3-1.4-1.4-1.5-1.3-1.3
LgA PC1 addiction-like behavior0.51.01.8-1.2-1.4-1.4-1.2-1.0-1.1-0.9-1.1-0.9-0.9-0.9-0.7-0.9-0.5
Time in closed arm before self-admin0.20.20.90.40.40.41.00.20.50.40.20.40.40.40.40.40.5
Time in closed arm after self-admin3.13.33.7-1.9-1.9-1.9-1.4-1.9-1.8-1.8-1.9-1.8-1.8-1.9-1.9-1.9-1.7
Time in open arm before self-admin0.80.81.1-0.9-0.9-0.9-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.9-1.0-0.9-1.0
Time in open arm after self-admin0.91.01.81.01.31.30.70.91.00.91.11.00.90.90.90.90.9
Bone: periosteal estimation0.71.42.21.31.31.31.51.11.21.11.11.11.21.21.11.20.9
Bone: periosteal perimeter1.42.53.01.71.71.71.61.51.41.71.61.51.61.71.51.61.2
Bone: post-yield work0.00.10.20.30.20.20.30.40.30.30.20.20.30.30.20.20.0
Progressive ratio test 1 active lever presses0.50.61.40.71.11.11.20.70.80.80.50.70.70.60.60.60.8
Progressive ratio test 1 breakpoint0.50.61.30.71.01.01.10.70.80.80.50.80.70.70.60.70.8
Progressive ratio test 1 inactive lever presses4.05.86.82.52.52.52.32.42.32.62.42.52.42.42.32.42.4
Progressive ratio test 2 active lever presses0.91.01.61.01.21.21.31.01.11.00.81.00.90.71.00.80.9
Progressive ratio test 2 breakpoint0.70.81.20.91.11.11.10.91.00.90.70.90.80.71.00.70.8
Progressive ratio test 2 inactive lever presses1.11.82.51.31.61.61.21.31.31.51.21.41.31.21.41.21.3
ShA PR total presses4.24.86.6-2.2-2.1-2.1-2.0-2.3-2.2-2.3-2.1-2.3-2.1-2.2-2.0-2.2-2.6
Incentive Sensitization - Responses0.20.30.50.60.70.70.50.60.60.60.60.60.50.40.70.50.4
Incentive Sensitization - Breakpoint0.20.20.40.50.60.60.40.50.50.50.50.50.40.30.60.40.3
LgA PR total presses1.81.92.7-1.5-1.4-1.3-1.7-1.5-1.4-1.4-1.3-1.3-1.5-1.5-1.1-1.5-1.0
Sum of active levers in priming session hrs 5-60.30.30.60.40.0-0.00.30.60.40.60.50.60.50.60.70.60.8
Progressive ratio0.10.20.6-0.4-0.3-0.30.2-0.8-0.5-0.4-0.5-0.5-0.6-0.7-0.5-0.4-0.4
Food seeking constrained by brief footshock2.53.06.01.71.81.72.51.71.61.81.61.61.71.61.71.91.4
Seeking ratio, punishment vs. effort0.81.11.70.90.80.81.01.31.01.21.01.11.21.21.11.11.0
Retroperitoneal fat weight0.62.43.51.61.61.60.11.61.31.71.91.81.61.51.51.61.6
Reaction time number correct0.00.10.20.20.10.1-0.30.40.30.20.30.30.30.30.20.10.2
Reaction time mean minus median0.61.53.4-1.1-1.2-1.2-1.8-1.1-1.1-1.3-0.7-1.2-1.1-1.2-1.4-0.9-1.3
Reaction time mean minus median AUC0.51.31.9-1.0-1.2-1.2-1.4-1.1-1.0-1.3-0.8-1.2-1.0-1.1-1.3-1.0-1.3
Reaction time num false alarms0.10.20.90.0-0.1-0.10.80.30.30.5-0.20.40.20.10.7-0.00.9
Reaction time num false alarms AUC0.10.20.8-0.2-0.3-0.40.90.10.10.3-0.40.2-0.0-0.10.5-0.20.8
Reaction time trials correct on left0.00.10.20.20.10.1-0.30.40.30.20.30.30.30.30.20.10.2
Reaction time trials on left0.00.00.10.10.00.0-0.30.40.20.10.20.20.20.20.20.00.2
Reaction time mean0.60.91.3-0.9-1.0-1.0-1.2-1.1-1.0-1.0-0.6-0.9-1.0-1.0-1.1-0.7-0.9
Reaction time mean AUC0.91.52.0-1.2-1.2-1.2-1.3-1.4-1.3-1.2-0.9-1.2-1.2-1.3-1.4-1.0-1.2
Median of all reaction times0.40.50.9-0.7-0.7-0.7-0.8-1.0-0.8-0.7-0.5-0.7-0.8-0.8-0.9-0.5-0.7
Reaction time omissions1.52.22.8-1.5-1.6-1.6-1.5-1.7-1.5-1.5-1.4-1.4-1.5-1.5-1.5-1.4-1.0
Reaction time false alarm rate0.10.21.0-0.2-0.3-0.31.00.00.00.3-0.40.1-0.1-0.20.4-0.20.7
Reaction time premature initiation rate3.04.14.9-2.2-2.2-2.2-1.4-1.9-2.1-2.0-2.1-2.1-2.0-2.0-2.0-2.1-2.0
Reaction time premature initiations1.32.33.0-1.7-1.7-1.7-1.2-1.3-1.5-1.5-1.5-1.5-1.4-1.4-1.4-1.6-1.5
Std. dev. reaction times0.81.53.1-1.1-1.2-1.2-1.8-1.3-1.2-1.3-0.8-1.2-1.2-1.2-1.4-1.0-1.2
Reaction time trials completed0.00.00.10.10.00.0-0.30.40.20.10.20.20.20.20.20.00.2
Reaction time trials AUC0.00.10.20.20.10.2-0.10.50.30.20.30.30.30.30.30.10.3
Run reversals in cocaine runway, females0.90.91.2-1.1-1.1-1.1-1.1-1.0-1.0-0.8-0.9-0.8-1.0-1.0-0.8-1.0-0.6
Run reversals in cocaine runway, males0.40.40.80.90.60.60.70.70.70.60.80.60.70.60.40.80.3
Latency to leave start box in cocaine runway0.00.10.30.20.10.10.4-0.20.10.2-0.10.2-0.0-0.00.20.10.5
Latency to leave start box in cocaine runway, F0.70.81.60.90.80.81.30.60.91.00.60.80.80.91.10.91.0
Latency to leave start box in cocaine runway, M0.70.71.3-0.8-0.6-0.6-0.8-1.0-0.8-0.8-0.8-0.7-1.0-1.1-1.0-0.9-0.4
Std. dev. time between licks in bursts0.00.00.1-0.1-0.2-0.2-0.4-0.00.0-0.00.00.10.00.00.1-0.10.1
Total sessions with >9 infusions0.80.91.9-0.9-0.6-0.60.1-1.0-0.7-1.1-1.4-1.1-1.0-1.1-1.1-1.1-1.1
Short access day 1 total inactive lever presses3.64.76.62.32.32.32.62.12.22.12.12.02.02.02.02.12.0
Short access day 10 total inactive lever presses0.00.10.20.30.30.30.10.40.30.40.50.40.30.30.40.20.4
Short access day 1 total infusions0.50.71.0-0.7-0.6-0.60.2-0.9-0.7-0.9-1.0-1.0-0.8-0.9-1.0-0.9-1.0
Short access day 10 total infusions0.30.40.8-0.5-0.0-0.00.5-0.7-0.3-0.6-0.9-0.6-0.6-0.7-0.7-0.7-0.7
Short access total infusions0.10.21.50.20.50.51.2-0.10.3-0.1-0.4-0.1-0.1-0.2-0.1-0.1-0.1
ShA early post infusion interval1.81.72.61.41.61.51.61.21.41.21.11.21.21.11.31.11.3
ShA late post infusion interval0.20.20.70.50.80.80.60.20.40.50.40.40.30.20.20.20.3
ShA early loading0.60.61.2-0.6-0.7-0.7-1.0-0.8-0.8-0.8-0.4-0.8-0.6-0.6-0.9-0.5-1.1
ShA late loading3.95.37.6-2.4-2.6-2.5-2.8-2.3-2.3-2.4-1.9-2.3-2.2-2.1-2.0-2.1-2.2
Short access day 1 locomotion0.91.22.4-1.1-0.9-0.90.1-1.1-1.0-1.1-1.6-1.3-1.0-1.0-1.2-1.0-1.2
Short access day 10 total locomotion0.71.21.9-1.1-0.8-0.8-0.1-1.3-1.1-1.2-1.3-1.3-1.1-1.1-1.4-1.2-1.3
Short access total locomotion1.31.62.4-1.2-1.0-1.0-0.2-1.4-1.2-1.4-1.6-1.5-1.3-1.3-1.5-1.3-1.4
ShA early average infusions0.30.31.6-0.5-0.5-0.5-1.2-0.6-0.6-0.5-0.1-0.4-0.4-0.4-0.4-0.4-0.8
ShA late average infusions3.63.84.5-2.0-2.0-2.0-1.7-2.0-2.0-2.0-1.9-2.0-1.9-1.9-1.8-1.8-2.1
ShA early timeout0.10.10.70.20.20.2-0.80.10.00.10.50.20.20.20.10.2-0.2
ShA late timeout1.31.42.1-1.1-1.4-1.4-1.4-1.1-1.3-1.2-0.9-1.3-1.1-1.0-1.0-0.9-1.5
ShA early titration0.40.51.3-0.7-0.7-0.7-1.2-0.7-0.7-0.6-0.3-0.5-0.6-0.6-0.6-0.6-0.7
ShA late titration3.74.04.6-2.1-2.1-2.1-1.9-2.0-2.1-2.0-1.9-2.0-1.9-1.9-1.8-1.9-2.0
ShA total infusions3.94.85.5-2.3-2.3-2.3-2.3-2.3-2.3-2.2-2.0-2.2-2.1-2.1-2.0-2.1-2.4
One hour access (0.3 mA shock)1.41.62.61.31.61.61.61.21.31.20.91.21.10.91.31.01.2
Shock compulsivity0.71.31.7-1.3-1.2-1.2-0.4-1.2-1.2-1.1-1.3-1.2-1.2-1.2-1.0-1.3-0.9
Compulsive drug intake1.92.32.8-1.5-1.4-1.4-1.3-1.6-1.4-1.5-1.5-1.5-1.6-1.7-1.4-1.6-1.5
One hour access (shock baseline)1.32.03.31.41.81.81.71.41.41.41.31.41.31.21.31.21.3
Social response proportion1.61.82.61.41.11.10.31.41.11.51.61.51.51.61.51.61.0
Social responses2.22.83.51.71.51.50.51.81.51.81.91.81.81.91.81.81.8
Social time0.10.20.40.30.20.2-0.60.40.20.40.50.50.40.50.20.50.6
Soleus weight0.61.85.41.31.61.52.31.01.21.31.01.11.21.21.11.41.0
Bone: stiffness0.00.10.2-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.3-0.2-0.2-0.3-0.2-0.4
Tibialis anterior weight1.34.24.72.12.12.11.92.22.22.01.92.12.12.22.11.92.0
Time to tail flick, vehicle, before self-admin0.00.00.1-0.10.0-0.00.2-0.1-0.10.2-0.00.10.0-0.00.1-0.10.1
Time to tail flick, vehicle, after self-admin0.20.20.4-0.7-0.5-0.5-0.5-0.5-0.6-0.3-0.6-0.4-0.5-0.5-0.5-0.5-0.1
Time to tail flick, test, before self-admin0.00.10.1-0.10.00.00.3-0.30.0-0.3-0.1-0.3-0.2-0.2-0.3-0.2-0.3
Time to tail flick, test, after self-admin2.72.83.51.61.71.71.91.71.61.81.51.71.61.61.71.61.8
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.4-0.2-0.2-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.6-0.4-0.6
Delta time to tail flick, test, before/after SA1.31.31.81.01.01.00.61.31.01.31.11.31.21.21.31.21.3
Tibia length0.20.61.3-0.8-0.4-0.40.7-1.1-0.7-0.7-1.0-0.8-0.8-0.6-0.9-0.6-0.6
Ambulatory time before self-admin0.50.72.80.80.80.81.70.71.00.60.70.60.70.60.70.60.7
Ambulatory time after self-admin0.00.00.5-0.0-0.0-0.10.7-0.10.1-0.0-0.1-0.1-0.0-0.1-0.1-0.10.1
Bone: tissue strength0.10.10.20.40.30.30.10.10.4-0.10.30.10.20.2-0.00.30.0
Total heroin consumption0.00.00.1-0.2-0.1-0.1-0.0-0.1-0.1-0.1-0.4-0.0-0.2-0.2-0.3-0.20.2
Total infusions1.62.12.7-1.6-1.6-1.5-1.6-1.5-1.5-1.5-1.5-1.4-1.4-1.4-1.2-1.4-1.2
Bone: trabecular number0.00.10.2-0.2-0.3-0.30.3-0.2-0.1-0.3-0.4-0.3-0.2-0.1-0.3-0.3-0.2
Bone: trabecular spacing1.21.61.91.31.31.30.91.31.21.31.31.31.21.31.21.41.1
Bone: trabecular thickness1.62.02.7-1.6-1.6-1.6-0.8-1.4-1.5-1.3-1.6-1.4-1.4-1.3-1.3-1.6-1.2
Bone: trabecular tissue density0.20.21.4-0.4-0.4-0.3-1.2-0.3-0.4-0.5-0.2-0.4-0.3-0.4-0.4-0.4-0.6
Water consumed over 24 hours1.31.82.61.51.21.20.51.61.41.31.51.41.51.51.41.31.2
Number of responses in last shaping day0.20.20.3-0.5-0.6-0.6-0.4-0.5-0.5-0.4-0.5-0.5-0.5-0.5-0.3-0.4-0.4