Hub : Genes

Xbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Xbp1 0.42 0.17 8.7e-15 0.32 0.33 0.4 0.4 1.5e-14 5.0e-15 2.7e-18 2.0e-18
2 IL mRNA stability Xbp1 0.53 0.17 2.1e-12 0.36 0.39 0.4 0.39 1.5e-09 2.0e-10 1.3e-10 2.6e-10
3 LHb mRNA stability Xbp1 0.36 0.16 3.5e-08 0.27 0.24 0.21 0.26 4.5e-07 2.5e-06 1.1e-05 8.2e-07
4 OFC mRNA stability Xbp1 0.49 0.16 3.9e-12 0.38 0.38 0.34 0.38 4.8e-10 7.7e-10 5.3e-09 4.9e-10
5 Brain mRNA stability Xbp1 0.52 0.14 0.0e+00 0.58 0.57 0.58 0.58 3.0e-65 4.3e-64 3.9e-66 5.1e-66
6 PL mRNA stability Xbp1 0.41 0.17 0.0e+00 0.42 0.45 0.43 0.46 9.4e-51 1.9e-54 3.8e-52 8.6e-56
7 BLA mRNA stability Xbp1 0.29 0.14 7.4e-14 0.21 0.22 0.2 0.22 1.7e-11 3.6e-12 7.6e-11 4.6e-12
8 Adipose mRNA stability Xbp1 0.14 0.07 0.0e+00 0.17 0.17 0.16 0.17 4.5e-18 4.6e-18 2.5e-17 4.3e-18
9 NAcc mRNA stability Xbp1 0.49 0.2 0.0e+00 0.32 0.32 0.33 0.32 1.1e-37 1.3e-38 6.4e-39 2.5e-38
10 Eye mRNA stability Xbp1 0.36 0.19 2.4e-03 0.05 0.16 0.13 0.14 6.8e-02 1.8e-03 4.5e-03 4.0e-03
11 Liver mRNA stability Xbp1 0.16 0.07 0.0e+00 0.2 0.2 0.2 0.2 9.2e-22 2.6e-21 1.1e-21 1.1e-21
12 pVTA mRNA stability Xbp1 0.36 0.15 0.0e+00 0.41 0.41 0.4 0.41 3.2e-19 5.3e-19 1.3e-18 2.5e-19
13 RMTg mRNA stability Xbp1 0.25 0.15 1.4e-05 0.12 0.2 0.22 0.21 3.4e-04 4.1e-06 1.8e-06 2.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.3-0.50.20.50.50.2-0.6-0.3-0.50.4-0.40.1-0.3-0.1
Area under the delay curve3.73.95.02.2-2.1-2.2-2.2-2.01.82.12.0-1.71.9-1.91.7-1.8
BMI with tail0.00.00.00.10.20.20.20.10.0-0.0-0.20.1-0.00.10.2-0.0
BMI without tail0.10.10.4-0.2-0.40.20.20.3-0.3-0.4-0.30.4-0.40.50.0-0.6
Body weight1.35.47.22.7-2.4-2.3-2.3-2.32.42.42.3-1.92.2-2.12.5-2.4
Weight adjusted by age0.50.61.60.8-1.1-0.8-0.8-0.70.60.70.7-0.40.6-0.80.6-1.3
Bone surface0.20.40.90.5-0.7-0.5-0.5-0.80.40.60.5-0.70.6-1.00.6-0.8
Bone volume0.20.40.70.5-0.7-0.4-0.4-0.80.30.60.4-0.60.5-0.80.6-0.9
Breakpoint value in progressive ratio session1.41.62.21.3-1.5-1.4-1.4-1.31.11.31.2-1.11.2-1.21.1-1.1
Number of licking bursts3.23.74.22.1-2.0-1.9-1.9-2.01.91.92.0-1.81.8-1.91.9-2.0
Context. condit. distance diff. score4.04.85.5-2.32.22.32.32.2-2.3-2.4-2.22.1-2.22.3-2.01.8
Locomotion velocity, session 10.20.21.20.10.5-0.3-0.3-0.10.70.20.3-0.50.3-0.10.01.1
Locomotion distance, session 10.81.01.3-1.21.11.11.10.8-1.1-0.7-0.91.1-1.00.8-1.00.8
Locomotion velocity, session 20.10.20.50.20.3-0.1-0.1-0.30.50.20.3-0.70.4-0.40.20.7
Locomotion distance, session 21.52.13.7-1.61.91.71.71.2-1.4-1.1-1.31.1-1.21.1-1.21.9
Locomotion velocity, session 32.63.14.2-2.01.82.12.11.5-1.9-1.7-1.81.6-1.71.5-1.61.3
Locomotion distance, session 30.20.20.60.2-0.30.20.2-0.8-0.10.40.2-0.60.4-0.70.6-0.5
Stereotopy head waving bouts, day 30.91.11.5-1.11.01.21.21.0-1.2-1.1-1.01.1-1.11.1-0.90.7
Stereotopy head waving duration, day 32.02.42.8-1.61.71.41.41.7-1.4-1.6-1.51.6-1.51.6-1.61.5
Locomotion velocity, session 70.20.20.30.5-0.3-0.4-0.4-0.60.40.50.4-0.40.5-0.50.6-0.4
Locomotion distance, session 70.20.30.7-0.60.80.70.70.4-0.6-0.5-0.50.4-0.40.4-0.40.7
Stereotopy head waving bouts, day 70.50.50.8-0.80.50.60.60.9-0.6-0.9-0.80.6-0.80.8-0.90.6
Stereotopy head waving duration, day 70.00.10.1-0.2-0.10.20.20.3-0.2-0.3-0.30.3-0.30.2-0.3-0.2
Locomotion velocity, session 81.21.52.6-1.31.61.31.31.1-1.1-1.2-1.10.8-1.01.1-1.01.6
Locomotion distance, session 88.111.913.6-3.73.63.63.63.4-3.5-3.5-3.43.1-3.33.4-3.23.3
Degree of sensitization distance2.12.13.2-1.51.71.21.21.7-1.1-1.5-1.31.4-1.41.6-1.51.8
Degree of sensitization stereotypy0.10.10.30.3-0.5-0.4-0.4-0.00.40.10.2-0.20.2-0.10.1-0.3
Conditioned locomotion1.41.62.3-1.31.21.41.41.1-1.5-1.1-1.31.5-1.31.3-1.20.7
Cocaine response after cond. corrected1.72.02.41.5-1.5-1.5-1.5-1.31.41.31.5-1.21.3-1.31.3-1.4
Cocaine response after cond. not corrected1.92.13.21.5-1.8-1.6-1.6-1.31.51.41.5-1.11.3-1.31.3-1.7
Cocaine response before conditioning0.30.40.6-0.80.50.70.70.6-0.7-0.6-0.70.7-0.70.6-0.70.4
Saline control response0.60.81.5-0.91.21.11.10.6-0.9-0.8-0.90.6-0.70.6-0.61.0
Bone: connectivity density0.20.30.6-0.70.50.70.70.4-0.7-0.6-0.70.6-0.60.3-0.50.2
Bone: cortical apparent density0.81.01.51.0-1.2-1.0-1.0-1.01.00.91.0-0.90.9-0.91.0-1.1
Bone: cortical area3.14.65.42.2-2.3-2.2-2.2-2.32.02.22.1-2.02.1-2.22.0-2.2
Bone: cortical porosity0.00.00.20.2-0.3-0.2-0.2-0.20.00.20.00.00.1-0.20.1-0.5
Bone: cortical porosity0.20.20.3-0.40.30.40.40.4-0.5-0.4-0.50.5-0.40.4-0.50.2
Bone: cortical thickness1.83.04.81.7-2.0-1.5-1.5-2.01.41.81.6-1.51.6-1.91.6-2.2
Bone: cortical thickness0.60.71.1-1.00.51.01.00.6-1.1-0.7-0.91.0-0.90.6-0.90.2
Bone: cortical tissue density0.81.11.51.1-1.2-1.1-1.1-1.01.11.01.0-1.01.0-0.91.1-1.1
Condit. Reinf. active minus inactive responses1.01.11.91.2-0.6-0.9-0.9-1.11.11.11.0-1.31.3-1.11.4-0.4
Condit. Reinf. active-inactive response ratio0.20.20.90.40.5-0.3-0.3-0.10.60.20.2-0.60.5-0.20.50.9
Condit. Reinf. active responses0.40.50.90.8-0.4-0.5-0.5-0.90.70.80.7-0.90.9-0.81.0-0.3
Condit. Reinf. inactive responses0.20.20.80.3-0.7-0.1-0.1-0.7-0.00.50.3-0.30.3-0.50.5-0.9
Incentive salience index mean1.31.52.41.4-1.0-1.0-1.0-1.41.11.31.2-1.31.4-1.31.6-0.8
Condit. Reinf. lever presses0.20.30.70.5-0.4-0.3-0.3-0.80.20.80.5-0.40.6-0.70.6-0.6
Condit. Reinf. active minus inactive responses0.50.61.0-0.81.00.80.80.7-0.7-0.7-0.70.7-0.70.6-0.60.9
Condit. Reinf. active-inactive response ratio0.00.00.1-0.00.40.20.20.1-0.1-0.0-0.00.2-0.00.10.00.4
Condit. Reinf. active responses0.60.91.8-1.01.30.90.90.9-0.7-0.8-0.80.8-0.80.7-0.81.3
Condit. Reinf. inactive responses0.81.01.8-1.01.30.90.91.0-0.7-1.0-0.90.8-0.90.7-1.01.3
Condit. Reinf. lever presses0.50.71.0-0.91.01.01.00.7-0.9-0.8-0.80.7-0.80.5-0.70.8
Condit. Reinf. lever reinforcers received0.50.71.6-0.91.30.90.90.8-0.7-0.7-0.80.7-0.70.6-0.81.2
Conditioned reinforcement - actives0.00.00.2-0.1-0.4-0.1-0.10.1-0.1-0.00.0-0.40.00.2-0.00.1
Conditioned reinforcement - inactives0.10.10.20.2-0.2-0.4-0.4-0.20.20.30.3-0.40.3-0.10.1-0.0
Conditioned locomotion0.10.10.6-0.1-0.8-0.4-0.40.0-0.30.00.1-0.40.00.10.2-0.4
Patch foraging indifference point 0 sec2.03.25.42.0-2.3-1.8-1.8-1.61.51.41.6-1.81.7-1.61.9-2.3
Patch foraging indifference point AUC0.20.20.50.4-0.3-0.4-0.4-0.50.50.40.4-0.70.5-0.60.4-0.2
Delay disc. indifference point, 0s delay0.91.01.41.1-1.1-1.2-1.2-1.00.91.01.0-0.60.9-0.90.8-1.1
Delay disc. indifference point, 16s delay3.13.24.22.0-1.7-2.1-2.1-1.71.81.81.8-1.71.9-1.61.7-1.2
Delay disc. indifference point, 2s delay1.01.12.41.1-1.4-1.1-1.1-1.10.71.11.0-0.40.9-0.90.9-1.5
Delay disc. indifference point, 24s delay1.71.62.11.5-1.1-1.3-1.3-1.31.31.31.3-1.31.3-1.21.3-0.8
Delay disc. indifference point, 4s delay3.03.14.12.0-2.0-1.9-1.9-1.81.51.91.8-1.21.7-1.61.6-2.0
Delay disc. indifference point, 8s delay1.21.31.71.2-1.0-1.3-1.3-1.21.01.31.2-1.01.1-1.10.9-0.7
Indifference point function ln k0.00.10.2-0.2-0.10.40.4-0.0-0.3-0.1-0.20.3-0.20.1-0.1-0.3
Indifference point function log k0.00.10.2-0.2-0.10.40.4-0.0-0.3-0.1-0.20.3-0.20.1-0.1-0.3
Patch foraging total patch changes 0 sec2.13.45.52.0-2.3-1.8-1.8-1.71.51.51.6-1.91.7-1.62.0-2.2
Patch foraging total patch changes 12 sec1.31.72.71.4-1.6-1.3-1.3-1.11.21.01.2-1.51.2-1.11.5-1.5
Patch foraging total patch changes 18 sec2.33.04.51.9-1.6-1.9-1.9-1.51.91.51.6-2.11.8-1.61.9-1.1
Patch foraging total patch changes 24 sec0.60.71.4-0.90.80.60.61.1-0.9-1.2-1.00.5-0.81.0-0.50.9
Patch foraging total patch changes 6 sec2.23.24.42.0-2.0-1.6-1.6-1.81.61.61.6-2.11.8-1.82.0-1.8
Patch foraging time to switch 0 sec0.50.81.3-1.00.80.60.61.1-0.7-0.9-0.81.1-0.91.1-0.80.8
Patch foraging water rate 0 sec2.03.24.12.0-1.9-1.5-1.5-1.91.61.71.6-2.01.8-1.81.9-1.7
Patch foraging water rate 12 sec0.10.10.20.4-0.20.10.1-0.40.10.30.2-0.40.3-0.20.4-0.4
Patch foraging water rate 18 sec0.10.20.7-0.2-0.20.30.30.3-0.4-0.3-0.40.8-0.50.7-0.3-0.5
Patch foraging water rate 24 sec0.10.10.30.4-0.0-0.2-0.2-0.20.50.30.2-0.40.3-0.10.30.3
Patch foraging water rate 6 sec0.30.40.60.6-0.7-0.6-0.6-0.70.60.70.7-0.50.6-0.60.6-0.8
Seeking ratio, delayed vs. immediate footshock0.30.40.9-0.60.50.20.20.7-0.4-0.4-0.50.9-0.60.8-0.60.8
Distance traveled before self-admin0.30.31.20.6-1.1-0.5-0.5-0.30.30.30.4-0.40.3-0.40.4-1.0
Distance traveled after self-admin0.20.20.80.6-0.9-0.2-0.2-0.30.20.30.3-0.20.3-0.30.5-0.9
Extensor digitorum longus weight3.513.617.03.9-4.1-3.5-3.5-3.73.53.63.6-3.53.5-3.73.7-3.9
Bone: elastic displacement0.70.81.1-1.00.60.90.90.9-1.0-1.0-1.01.0-1.01.0-0.90.3
Bone: elastic work0.10.10.7-0.0-0.5-0.0-0.00.0-0.2-0.1-0.10.4-0.20.20.1-0.8
Bone: endosteal estimation0.10.20.40.5-0.6-0.6-0.6-0.10.60.30.4-0.30.3-0.10.4-0.4
Bone: endosteal perimeter0.71.42.01.3-1.2-1.4-1.4-1.01.31.21.2-1.01.1-0.91.0-0.8
Epididymis fat weight0.40.81.2-1.00.71.11.10.9-0.9-1.0-1.00.9-1.10.8-0.90.2
Delta time in closed arm before/after self-admin7.27.07.7-2.72.72.62.62.7-2.6-2.6-2.62.7-2.62.7-2.82.5
Delta time in open arm before/after self-admin9.08.710.63.1-3.0-3.3-3.3-2.93.12.92.9-2.62.9-2.83.0-2.7
Diff in mean of infusions in LGA sessions0.30.30.7-0.40.30.30.30.7-0.6-0.6-0.60.8-0.60.7-0.50.3
Delay discount exponential model param3.33.54.4-2.12.02.12.11.9-1.7-2.0-1.91.6-1.81.8-1.61.7
Extinction: sum of active levers before priming0.60.61.10.9-0.7-0.6-0.6-0.80.80.80.6-1.10.8-0.70.7-0.3
Active lever presses in extinction session 60.10.10.30.3-0.5-0.5-0.5-0.20.20.30.20.10.2-0.10.1-0.4
Bone: final force0.40.71.10.9-1.0-0.7-0.7-0.80.70.70.7-0.70.7-0.61.0-1.0
Bone: final moment0.60.91.61.1-1.2-0.9-0.9-1.00.90.80.9-0.90.9-0.81.1-1.2
Food consumed during 24 hour testing period2.32.73.51.7-1.3-1.6-1.6-1.71.71.71.7-1.91.8-1.91.7-1.1
Glucose19.829.840.65.9-4.4-5.6-5.6-5.56.15.45.6-6.45.9-5.65.3-2.8
Heart weight0.30.40.9-0.60.90.80.80.5-0.5-0.7-0.70.1-0.50.4-0.51.0
Delay discount hyperbolic model param3.33.54.4-2.12.02.12.11.9-1.7-2.0-1.91.5-1.81.8-1.71.8
Intermittent access intake day 1-15 change0.40.41.70.6-0.7-0.4-0.4-0.60.50.50.5-1.30.7-0.70.7-0.2
Intermittent access intake escalation0.20.21.10.4-0.5-0.2-0.2-0.40.40.30.3-1.10.5-0.50.5-0.1
Intermittent access intake escalation 20.20.20.80.4-0.4-0.2-0.2-0.40.40.20.3-0.90.4-0.40.3-0.1
Intermitt. access day 1 inactive lever presses0.91.02.1-0.81.41.21.20.8-0.6-0.7-0.80.8-0.80.9-0.71.4
Intermitt. access day 15 inactive lever presses1.01.11.71.3-0.4-0.9-0.9-1.11.21.21.2-1.31.3-1.01.2-0.2
Intermitt. access escalation Index0.20.10.50.4-0.2-0.2-0.2-0.40.40.30.3-0.70.5-0.50.4-0.2
Intermittent access day 1 total infusions0.20.20.5-0.5-0.1-0.2-0.20.6-0.6-0.4-0.30.5-0.50.7-0.60.1
Intermittent access day 15 total infusions0.30.30.70.4-0.8-0.8-0.8-0.40.30.40.5-0.80.4-0.30.3-0.4
Intermittent access terminal intake (last 3 days)0.20.20.70.2-0.8-0.7-0.7-0.20.10.20.3-0.70.3-0.20.1-0.4
Intermittent access total infusions0.10.10.50.1-0.7-0.6-0.6-0.0-0.10.10.2-0.40.10.1-0.0-0.4
Intermittent access day 1 locomotion0.90.91.4-1.20.70.60.61.1-1.1-1.0-0.90.9-1.01.2-1.10.9
Intermittent access day 15 total locomotion0.20.20.50.4-0.6-0.7-0.7-0.40.40.50.4-0.60.5-0.30.4-0.2
Intermittent access total locomotion0.30.30.70.4-0.8-0.9-0.9-0.40.40.50.4-0.60.5-0.20.3-0.4
Intermittent access standard deviation1.21.21.8-1.20.81.11.11.2-1.2-1.3-1.10.6-1.21.2-1.30.9
Left kidney weight0.00.10.4-0.20.10.20.20.4-0.0-0.3-0.20.6-0.50.5-0.30.1
Right kidney weight0.92.64.1-1.51.21.51.51.8-1.4-1.7-1.62.0-1.82.0-1.60.9
Cocaine induced anxiety3.13.54.32.0-1.9-1.8-1.8-2.11.62.01.9-1.91.9-1.91.8-1.8
Post-drug Anxiety1.11.21.71.1-0.9-1.1-1.1-1.31.01.21.2-1.21.2-1.20.9-0.7
Baseline Anxiety0.30.31.2-0.60.80.30.30.4-0.1-0.3-0.30.4-0.30.3-0.51.1
Tail length1.44.29.12.2-2.9-2.1-2.1-1.81.71.71.9-1.41.6-1.52.0-3.0
Length with tail2.17.79.73.1-3.1-3.0-3.0-2.72.82.72.8-2.22.5-2.42.7-2.9
Length without tail1.32.93.92.0-1.3-1.9-1.9-1.81.91.91.8-1.61.8-1.71.6-0.9
Times rat made contact with spout0.20.20.80.30.2-0.3-0.3-0.30.60.10.5-0.90.5-0.50.20.5
Lifetime Intake0.20.20.70.2-0.8-0.7-0.7-0.0-0.00.10.2-0.30.10.10.0-0.6
Liver weight, left2.13.45.4-1.91.41.51.52.1-1.6-1.9-1.92.3-2.12.2-1.91.0
Liver weight, right4.06.69.2-2.82.52.32.32.8-2.3-2.4-2.53.0-2.72.7-2.92.0
Locomotor activity0.71.11.81.3-1.1-1.2-1.2-0.81.40.91.1-1.21.1-0.81.1-0.6
Locomotor testing distance0.20.31.10.5-0.9-0.5-0.5-0.30.30.30.6-0.10.3-0.20.6-1.1
Locomotor testing rearing2.03.13.71.9-1.9-1.7-1.7-1.71.71.61.9-1.81.7-1.61.9-1.7
Locomotion in novel chamber5.06.27.3-2.72.62.32.32.6-2.5-2.5-2.42.6-2.52.4-2.62.1
Locomotion in novel chamber post-restriction3.34.07.6-2.12.81.81.82.0-1.6-1.7-1.81.8-1.71.9-1.92.6
Fecal boli incidents, locomotor time 10.20.30.6-0.60.80.50.50.4-0.3-0.4-0.40.7-0.40.3-0.40.6
Change in fecal boli incidents, locomotor task0.10.10.30.4-0.2-0.3-0.3-0.10.50.10.3-0.60.3-0.20.40.0
Time >=10cm from walls, locomotor time 10.10.10.2-0.40.30.10.10.10.1-0.1-0.00.0-0.2-0.1-0.50.4
Bouts of movement, locomotor time 10.60.71.10.9-0.5-0.9-0.9-0.81.00.70.8-1.10.9-0.90.8-0.2
Total resting periods, locomotor time 10.30.30.50.5-0.0-0.5-0.5-0.40.70.50.5-0.70.7-0.60.50.2
Rest time, locomotor task time 10.10.10.3-0.00.2-0.1-0.1-0.30.40.30.3-0.50.3-0.50.00.3
Distance moved, locomotor task time 10.20.20.90.6-1.0-0.4-0.4-0.30.20.30.3-0.40.3-0.10.5-0.8
Vertical activity count, locomotor time 10.10.10.50.4-0.7-0.4-0.4-0.10.00.10.2-0.20.10.10.2-0.4
Time >=10cm from walls, locomotor time 20.30.30.8-0.60.70.10.10.7-0.2-0.4-0.40.8-0.50.5-0.90.9
Bouts of movement, locomotor time 20.00.00.10.1-0.0-0.1-0.10.1-0.20.1-0.10.3-0.00.30.3-0.1
Total resting periods, locomotor time 20.00.00.20.2-0.1-0.2-0.2-0.0-0.00.20.00.10.10.20.4-0.1
Rest time, locomotor task time 20.00.00.1-0.30.20.30.30.0-0.0-0.2-0.1-0.1-0.1-0.1-0.00.1
Distance moved, locomotor task time 20.10.10.3-0.30.30.30.30.3-0.2-0.2-0.30.1-0.20.3-0.40.6
Vertical activity count, locomotor time 20.10.10.4-0.40.30.10.10.2-0.2-0.1-0.20.1-0.20.1-0.60.4
Light reinforcement 10.10.20.50.3-0.7-0.3-0.3-0.40.00.30.3-0.40.2-0.50.4-0.7
Light reinforcement 20.10.10.20.2-0.3-0.5-0.5-0.00.20.30.20.40.00.1-0.1-0.4
Bone: marrow area0.10.10.30.4-0.5-0.5-0.5-0.00.50.20.3-0.20.20.00.3-0.3
Bone: maximum diameter5.29.611.13.3-2.9-3.2-3.2-3.13.23.23.2-3.23.2-3.13.0-2.4
Bone: maximum force0.30.51.00.8-1.0-0.6-0.6-0.70.60.60.6-0.60.6-0.60.8-1.0
Bone: maximum moment0.50.81.60.9-1.2-0.8-0.8-0.90.80.80.8-0.80.8-0.81.0-1.3
Mean time between licks in bursts0.60.81.41.0-0.4-1.0-1.0-0.91.20.91.1-1.11.1-0.70.80.2
Mean num. licks in bursts1.92.34.3-1.61.91.41.41.6-1.3-1.6-1.41.0-1.31.4-1.42.1
Cd content in liver0.30.30.6-0.60.40.60.60.7-0.6-0.6-0.60.8-0.60.7-0.50.3
Co content in liver0.00.10.20.2-0.30.30.3-0.1-0.3-0.1-0.1-0.10.0-0.00.4-0.5
Cu content in liver0.50.60.70.8-0.7-0.7-0.7-0.90.80.70.8-0.80.8-0.80.8-0.6
Fe content in liver0.40.52.9-0.51.40.30.30.4-0.2-0.3-0.40.2-0.20.4-0.51.7
K content in liver0.50.51.80.5-1.0-0.5-0.5-0.90.30.80.6-0.30.4-0.70.4-1.4
Mg content in liver0.30.30.70.5-0.7-0.4-0.4-0.80.20.60.5-0.60.5-0.80.5-0.8
Mn content in liver0.10.21.10.0-0.60.10.1-0.4-0.40.2-0.00.1-0.0-0.30.1-1.1
Na content in liver4.54.75.32.3-1.9-2.3-2.3-2.32.22.32.2-2.22.3-2.32.1-1.5
Rb content in liver2.93.75.32.0-2.3-1.8-1.8-1.91.61.91.8-1.71.8-1.91.8-2.3
Se content in liver1.61.92.81.4-1.5-1.2-1.2-1.61.11.51.3-1.21.3-1.51.4-1.7
Sr content in liver1.91.72.41.6-0.9-1.5-1.5-1.31.61.41.5-1.11.4-1.11.4-0.7
Zn content in liver0.20.20.40.5-0.5-0.4-0.4-0.60.40.60.6-0.30.5-0.50.5-0.6
Bone: minimum diameter0.00.00.0-0.1-0.1-0.1-0.10.1-0.10.0-0.10.2-0.10.0-0.1-0.2
Time in familiar zone, hab. session 10.10.10.3-0.30.20.40.40.3-0.5-0.4-0.40.4-0.40.4-0.20.1
Time in novel zone, hab. session 10.40.40.70.6-0.7-0.7-0.7-0.50.70.50.6-0.50.5-0.60.4-0.8
Total zone transitions, hab. session 10.00.00.10.00.10.00.0-0.20.10.20.1-0.30.2-0.30.00.2
Total locomotion distance, hab. session 10.10.10.30.2-0.2-0.3-0.3-0.50.20.50.3-0.20.3-0.50.2-0.3
Locomotion velocity, hab. session 10.00.00.1-0.10.2-0.1-0.1-0.20.10.30.1-0.20.1-0.3-0.10.3
Time in familiar zone, hab. session 21.91.92.7-1.41.41.21.21.6-1.2-1.5-1.41.4-1.41.7-1.21.4
Time in novel zone, hab. session 22.82.83.91.6-1.8-1.4-1.4-1.91.41.61.6-1.81.6-2.01.5-1.8
Total zone transitions, hab. session 20.70.91.50.9-0.7-0.8-0.8-1.20.91.21.1-1.01.0-1.10.9-0.6
Total locomotion distance, hab. session 20.91.22.01.0-0.8-0.9-0.9-1.41.01.41.2-1.31.2-1.41.1-0.6
Locomotion velocity, hab. session 21.11.52.51.2-0.9-1.1-1.1-1.51.11.61.3-1.31.3-1.51.2-0.7
Novel to familiar place preference ratio0.91.01.60.9-0.7-1.2-1.2-0.91.31.01.0-1.11.0-1.00.6-0.3
Novelty place preference1.11.11.81.0-0.7-1.2-1.2-1.01.31.01.1-1.21.1-1.10.6-0.3
Time in novel zone, NPP test1.01.01.70.9-0.7-1.2-1.2-1.01.31.01.1-1.21.0-1.10.7-0.4
Total zone transitions, NPP test0.50.71.1-1.00.81.01.00.6-1.1-0.6-0.80.9-0.80.7-0.70.5
Total locomotion distance, NPP test0.10.10.3-0.50.50.50.50.1-0.5-0.0-0.30.4-0.30.2-0.30.4
Locomotion velocity, NPP test0.00.00.1-0.20.30.20.2-0.1-0.20.2-0.10.2-0.1-0.0-0.10.3
Intraocular pressure0.40.61.00.8-0.4-0.7-0.7-0.71.00.80.8-0.90.9-0.80.8-0.1
Delta distance traveled before/after self-admin0.30.30.6-0.50.80.70.70.5-0.3-0.4-0.50.5-0.50.5-0.40.8
Delta ambulatory time before/after self-admin0.60.61.1-0.71.11.01.00.7-0.5-0.6-0.70.7-0.70.7-0.61.0
Parametrial fat weight2.14.26.12.4-1.6-2.1-2.1-1.92.52.22.1-2.32.2-1.91.9-0.8
Pavlov. Cond. lever latency0.60.81.31.0-0.7-1.1-1.1-0.71.20.80.9-1.00.9-0.80.8-0.4
Pavlov. Cond. magazine entry latency2.33.04.1-1.91.82.02.01.5-2.0-1.7-1.81.6-1.71.5-1.61.3
Pavlov. Cond. change in total contacts1.01.01.61.1-1.0-0.7-0.7-1.30.71.10.9-1.01.1-1.11.2-1.1
Pavlov. Cond. index score2.63.24.6-2.01.82.12.11.6-2.1-1.7-1.91.8-1.71.6-1.61.3
Pavlov. Cond. latency score2.12.73.7-1.81.61.91.91.4-1.9-1.5-1.71.6-1.61.5-1.51.2
Pavlov. Cond. lever contacts1.01.22.1-1.21.11.41.40.8-1.4-0.9-1.21.1-1.00.9-0.90.7
Pavlov. Cond. magazine entry number2.53.14.51.9-1.9-2.1-2.1-1.52.11.71.9-1.51.6-1.51.5-1.4
Pavlov. Cond. intertrial magazine entries0.30.40.80.6-0.9-0.8-0.8-0.50.60.70.6-0.10.4-0.30.4-0.9
Pavlov. Cond. lever-magazine prob. diff.3.03.75.3-2.11.92.22.21.7-2.3-1.8-2.01.9-1.91.7-1.71.4
Pavlov. Cond. response bias1.31.63.0-1.31.21.71.70.9-1.7-1.1-1.41.2-1.20.9-1.00.7
Pavlov. Cond. lever latency3.64.96.82.3-2.6-2.3-2.3-2.22.02.32.3-1.72.0-1.92.0-2.6
Pavlov. Cond. magazine entry latency0.00.00.1-0.20.10.30.3-0.1-0.3-0.0-0.1-0.1-0.1-0.2-0.2-0.1
Pavlov. Cond. change in total contacts0.20.30.6-0.60.70.50.50.6-0.4-0.5-0.50.5-0.50.6-0.50.8
Pavlov. Cond. index score1.31.72.3-1.41.51.41.41.2-1.3-1.3-1.31.0-1.21.0-1.31.4
Pavlov. Cond. latency score1.41.82.4-1.51.51.51.51.2-1.4-1.3-1.41.1-1.21.1-1.31.4
Pavlov. Cond. lever contacts3.04.06.0-2.12.42.02.02.1-1.7-2.1-2.01.6-1.81.8-1.92.5
Pavlov. Cond. magazine entry number0.00.00.10.1-0.1-0.2-0.20.10.10.10.10.3-0.00.20.0-0.1
Pavlov. Cond. intertrial magazine entries0.00.00.00.10.1-0.0-0.00.00.00.10.0-0.00.1-0.00.20.2
Pavlov. Cond. lever-magazine prob. diff.1.31.62.0-1.41.41.41.41.2-1.3-1.3-1.31.0-1.21.0-1.31.3
Pavlov. Cond. response bias1.11.52.6-1.31.51.31.31.3-1.0-1.3-1.20.8-1.11.1-1.21.6
Time in closed arm before self-admin0.50.61.30.7-1.1-0.7-0.7-0.70.60.60.7-0.50.6-0.60.7-1.2
Time in closed arm after self-admin2.32.33.1-1.51.31.71.71.6-1.8-1.5-1.61.4-1.51.5-1.51.1
Time in open arm before self-admin2.73.03.5-1.91.91.71.71.7-1.6-1.7-1.71.5-1.71.5-1.91.8
Time in open arm after self-admin0.30.30.80.5-0.1-0.9-0.9-0.40.70.50.5-0.40.6-0.40.40.2
Bone: periosteal estimation1.12.22.91.6-1.7-1.6-1.6-1.41.51.41.5-1.31.4-1.31.3-1.5
Bone: periosteal perimeter1.93.23.81.9-1.9-2.0-2.0-1.81.91.91.8-1.71.7-1.71.6-1.5
Bone: post-yield work0.20.30.50.6-0.7-0.5-0.5-0.50.60.60.6-0.70.5-0.70.5-0.6
Progressive ratio test 1 active lever presses0.00.00.2-0.1-0.3-0.4-0.40.10.10.10.1-0.10.10.2-0.00.0
Progressive ratio test 1 breakpoint0.10.10.3-0.50.1-0.1-0.10.4-0.3-0.3-0.30.2-0.30.5-0.40.3
Progressive ratio test 1 inactive lever presses2.22.43.21.8-1.4-1.6-1.6-1.71.61.81.6-1.31.6-1.41.6-1.1
Progressive ratio test 2 active lever presses0.10.10.40.1-0.6-0.4-0.40.00.00.00.1-0.40.10.1-0.1-0.2
Progressive ratio test 2 breakpoint0.10.10.40.2-0.6-0.4-0.4-0.10.00.10.2-0.50.20.0-0.0-0.2
Progressive ratio test 2 inactive lever presses0.70.81.30.9-0.9-1.0-1.0-0.80.80.90.9-1.10.9-0.70.7-0.4
Incentive Sensitization - Responses0.00.10.20.2-0.4-0.2-0.2-0.10.10.10.2-0.50.2-0.10.0-0.0
Incentive Sensitization - Breakpoint0.00.00.20.1-0.3-0.1-0.1-0.00.00.00.1-0.40.1-0.0-0.10.0
Sum of active levers in priming session hrs 5-60.80.81.31.0-0.7-0.5-0.5-1.21.11.00.9-0.80.9-1.01.1-0.7
Progressive ratio0.10.20.4-0.40.00.10.10.5-0.4-0.4-0.40.7-0.40.6-0.60.1
Food seeking constrained by brief footshock1.82.23.71.5-1.9-1.5-1.5-1.51.31.61.4-1.11.3-1.41.3-1.9
Seeking ratio, punishment vs. effort1.11.41.81.2-1.0-0.9-0.9-1.31.11.31.2-1.21.1-1.31.3-1.1
Retroperitoneal fat weight0.00.10.50.10.50.10.10.10.20.1-0.20.10.00.10.10.7
Reaction time number correct0.10.10.50.2-0.3-0.1-0.1-0.30.20.20.3-0.70.3-0.50.40.0
Reaction time mean minus median1.41.93.2-1.41.71.31.31.5-0.9-1.4-1.31.1-1.21.2-1.31.8
Reaction time mean minus median AUC1.11.51.9-1.31.31.31.31.3-0.9-1.4-1.21.1-1.21.1-1.21.3
Reaction time num false alarms0.20.31.10.3-0.7-0.0-0.0-0.8-0.30.50.2-0.30.4-0.60.7-1.0
Reaction time num false alarms AUC0.20.21.20.2-0.70.10.1-0.6-0.50.40.0-0.10.2-0.40.6-1.1
Reaction time trials correct on left0.10.10.50.2-0.3-0.1-0.1-0.30.20.20.3-0.70.3-0.50.40.0
Reaction time trials on left0.10.10.50.2-0.2-0.1-0.1-0.20.20.20.2-0.70.3-0.40.30.1
Reaction time mean0.81.21.8-1.01.31.01.01.2-0.7-1.1-1.01.1-1.01.3-0.91.3
Reaction time mean AUC1.41.82.5-1.31.61.31.31.5-1.0-1.3-1.31.4-1.31.5-1.21.5
Median of all reaction times0.50.61.1-0.71.00.60.60.9-0.5-0.7-0.70.9-0.71.1-0.71.0
Reaction time omissions1.41.92.5-1.31.31.61.61.4-1.3-1.5-1.51.4-1.41.5-1.01.2
Reaction time false alarm rate0.10.21.20.1-0.50.10.1-0.5-0.50.3-0.00.30.1-0.20.4-1.1
Reaction time premature initiation rate3.24.25.6-2.12.02.42.41.9-2.1-2.0-2.12.2-2.11.8-2.11.4
Reaction time premature initiations1.52.23.4-1.51.41.81.81.2-1.5-1.4-1.51.4-1.51.2-1.51.1
Std. dev. reaction times1.31.82.9-1.31.71.31.31.4-0.9-1.4-1.31.2-1.21.4-1.21.7
Reaction time trials completed0.10.10.50.2-0.2-0.1-0.1-0.20.20.20.2-0.70.3-0.40.30.1
Reaction time trials AUC0.10.10.60.3-0.4-0.2-0.2-0.40.30.30.3-0.80.4-0.50.4-0.1
Run reversals in cocaine runway, females0.70.71.0-0.80.91.01.00.6-0.9-0.7-0.90.8-0.70.8-0.70.8
Run reversals in cocaine runway, males0.50.50.60.7-0.8-0.8-0.8-0.60.70.60.7-0.70.6-0.70.6-0.7
Latency to leave start box in cocaine runway0.10.10.30.3-0.20.00.0-0.0-0.20.0-0.10.30.00.30.5-0.4
Latency to leave start box in cocaine runway, F0.40.40.90.9-0.7-0.5-0.5-0.70.40.60.6-0.10.5-0.30.9-1.0
Latency to leave start box in cocaine runway, M0.80.71.1-0.90.70.70.71.0-0.9-0.9-1.00.8-0.81.0-0.60.7
Std. dev. time between licks in bursts0.00.00.10.00.00.10.1-0.1-0.00.00.1-0.20.1-0.00.10.2
Total sessions with >9 infusions0.10.10.3-0.4-0.4-0.0-0.00.1-0.5-0.2-0.1-0.0-0.20.3-0.3-0.3
Short access day 1 total inactive lever presses3.33.75.52.1-2.3-2.1-2.1-1.81.61.91.8-1.61.8-1.71.9-2.2
Short access day 10 total inactive lever presses0.30.30.8-0.40.90.70.70.4-0.5-0.4-0.50.5-0.40.5-0.40.7
Short access day 1 total infusions0.30.30.7-0.6-0.00.20.20.7-0.6-0.7-0.50.6-0.70.8-0.60.0
Short access day 10 total infusions0.30.30.8-0.70.0-0.0-0.00.8-0.7-0.6-0.50.8-0.70.9-0.60.0
Short access total infusions0.40.40.8-0.8-0.10.10.10.8-0.9-0.8-0.60.7-0.80.9-0.7-0.1
Short access day 1 locomotion1.71.83.1-1.60.71.11.11.4-1.8-1.4-1.31.4-1.61.5-1.30.6
Short access day 10 total locomotion0.60.71.3-1.00.30.50.51.0-0.7-0.8-0.80.9-0.91.1-1.00.6
Short access total locomotion3.53.65.2-2.31.31.61.62.1-2.0-2.1-1.91.9-2.12.1-2.01.3
One hour access (0.3 mA shock)0.10.10.2-0.0-0.4-0.4-0.40.2-0.2-0.1-0.1-0.1-0.10.3-0.3-0.1
Compulsive drug intake2.72.83.7-1.71.91.81.81.6-1.7-1.6-1.61.5-1.61.6-1.51.6
One hour access (shock baseline)0.91.12.21.0-1.5-1.5-1.5-0.80.90.90.8-1.10.9-0.70.5-0.9
Social response proportion1.92.13.31.5-0.6-1.3-1.3-1.71.71.81.6-1.51.7-1.51.3-0.3
Social responses2.43.14.11.9-1.3-1.6-1.6-2.01.82.01.8-2.02.0-1.91.9-0.9
Social time0.20.30.60.60.0-0.4-0.4-0.60.60.70.6-0.70.7-0.60.80.1
Soleus weight0.72.13.61.5-1.9-1.6-1.6-1.31.41.41.5-0.81.2-1.01.2-1.9
Bone: stiffness0.00.00.0-0.0-0.1-0.0-0.00.10.2-0.10.0-0.1-0.00.2-0.10.1
Tibialis anterior weight1.34.45.42.3-2.2-2.1-2.1-2.02.12.02.1-2.12.1-2.02.1-1.9
Time to tail flick, vehicle, before self-admin0.00.00.2-0.20.10.20.20.1-0.2-0.0-0.20.4-0.20.2-0.30.1
Time to tail flick, vehicle, after self-admin0.00.00.1-0.0-0.00.20.2-0.1-0.20.1-0.10.3-0.00.10.1-0.2
Time to tail flick, test, before self-admin0.60.60.9-0.90.80.70.70.8-0.5-1.0-0.70.7-0.80.8-0.80.6
Time to tail flick, test, after self-admin2.93.03.91.8-1.8-1.6-1.6-2.01.61.91.7-1.41.7-1.81.7-1.8
Delta time to tail flick, vehicle, before/after SA0.00.00.00.00.1-0.2-0.20.10.00.00.10.2-0.00.1-0.00.0
Delta time to tail flick, test, before/after SA2.22.02.71.5-1.4-1.2-1.2-1.61.21.61.4-1.41.5-1.51.4-1.2
Tibia length0.10.30.8-0.5-0.10.30.30.6-0.4-0.5-0.40.9-0.70.8-0.5-0.3
Ambulatory time before self-admin0.70.72.20.8-1.5-0.8-0.8-0.60.50.50.6-0.50.5-0.60.7-1.5
Ambulatory time after self-admin0.20.20.70.6-0.9-0.4-0.4-0.40.40.50.4-0.30.3-0.30.5-0.8
Bone: tissue strength0.10.10.20.3-0.4-0.3-0.30.10.5-0.00.3-0.40.20.00.2-0.1
Total heroin consumption0.10.10.30.3-0.6-0.5-0.5-0.3-0.00.20.2-0.30.3-0.30.0-0.3
Bone: trabecular number0.10.10.2-0.3-0.10.30.30.2-0.4-0.3-0.40.4-0.40.1-0.2-0.3
Bone: trabecular spacing1.11.41.91.3-1.0-1.3-1.3-1.21.31.21.4-1.21.2-1.11.1-0.8
Bone: trabecular thickness1.31.62.2-1.41.01.41.41.2-1.5-1.2-1.41.3-1.31.2-1.20.7
Bone: trabecular tissue density0.20.31.2-0.50.80.30.30.6-0.1-0.4-0.4-0.0-0.30.4-0.51.1
Water consumed over 24 hours1.61.93.01.4-1.1-1.3-1.3-1.41.51.31.4-1.71.5-1.61.3-0.8
Number of responses in last shaping day0.10.10.2-0.2-0.10.30.30.2-0.3-0.2-0.30.2-0.30.40.0-0.1