Hub : Genes

Wsb2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr12_44880363_44880470 0.1 0.06 9.2e-10 0.1 0.09 0.1 0.04 3.5e-11 7.7e-10 3.0e-11 9.2e-06
2 Adipose mRNA stability Wsb2 0.04 0.02 1.7e-03 0.01 0.02 0 0.01 1.5e-02 1.2e-03 2.4e-01 7.1e-03
3 Adipose gene expression Wsb2 0.02 0.01 5.1e-04 0.01 0.02 0.03 0.01 7.8e-03 1.5e-03 1.1e-04 1.3e-02
4 NAcc gene expression Wsb2 0.06 0.03 1.7e-11 0.07 0.07 0.07 0.07 1.8e-11 6.3e-11 1.1e-10 1.7e-11
5 PL gene expression Wsb2 0.1 0.05 5.3e-10 0.09 0.08 0.08 0.08 1.3e-09 1.1e-08 9.6e-09 3.0e-09
6 Brain gene expression Wsb2 0.05 0.03 4.1e-05 0.04 0.04 0.03 0.04 2.0e-04 2.5e-04 4.0e-04 3.2e-04
7 Adipose intron excision ratio chr12_44880580_44881070 0.13 0.07 6.0e-11 0.12 0.1 0.11 0.04 5.0e-13 1.0e-10 2.4e-12 1.6e-05
8 Brain mRNA stability Wsb2 0.15 0.09 4.4e-08 0.09 0.05 0.08 0.07 1.3e-08 2.1e-05 5.8e-08 2.8e-07
9 BLA gene expression Wsb2 0.07 0.04 2.9e-04 0.06 0.06 0.05 0.05 3.7e-04 4.4e-04 1.2e-03 1.6e-03
10 PL mRNA stability Wsb2 0.04 0.02 2.2e-05 0.01 0.04 0.03 0.04 1.6e-02 4.1e-05 1.2e-04 7.2e-05
11 OFC mRNA stability Wsb2 0.16 0.09 4.8e-03 0.09 0.07 0.09 0.09 4.1e-03 8.7e-03 3.7e-03 3.4e-03
12 Liver gene expression Wsb2 0.26 0.08 0.0e+00 0.25 0.23 0.24 0.25 1.5e-27 1.6e-25 1.4e-26 7.1e-28

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.62.88.2-0.30.12.91.62.12.12.22.21.20.81.60.2
Area under the delay curve1.41.75.7-2.4-0.9-1.6-1.5-1.1-1.0-1.1-1.1-1.3-1.1-0.5-0.9
BMI with tail0.20.72.21.5-0.90.8-0.30.2-0.31.21.2-0.70.6-0.60.5
BMI without tail0.10.31.10.5-1.0-0.1-0.70.1-0.70.60.6-0.9-0.1-0.7-0.2
Body weight0.31.12.71.6-0.30.60.00.6-0.41.61.6-0.31.3-0.81.6
Weight adjusted by age1.21.84.8-0.82.20.71.61.21.40.90.91.41.81.01.4
Bone surface0.20.30.70.1-0.70.5-0.7-0.4-0.4-0.3-0.3-0.3-0.8-0.6-0.7
Bone volume0.20.41.9-0.5-0.71.4-0.00.40.50.40.40.2-0.60.3-0.7
Breakpoint value in progressive ratio session0.50.64.12.0-0.2-0.6-0.4-0.2-0.7-0.0-0.0-0.50.4-1.10.8
Number of licking bursts1.52.44.70.11.70.92.21.51.71.51.52.01.71.41.3
Context. condit. distance diff. score0.30.41.0-0.00.8-1.0-0.3-0.8-0.6-0.8-0.80.2-0.2-0.4-0.2
Locomotion velocity, session 10.60.62.31.11.5-0.20.0-0.5-0.1-0.9-0.9-0.20.7-0.51.1
Locomotion distance, session 10.20.21.81.30.10.7-0.1-0.10.1-0.2-0.2-0.5-0.3-0.2-0.1
Locomotion velocity, session 20.20.31.9-1.40.4-0.1-0.2-0.10.0-0.4-0.40.1-0.50.3-0.4
Locomotion distance, session 20.30.51.91.4-0.51.10.10.80.40.80.8-0.30.10.10.0
Locomotion velocity, session 30.50.62.60.81.6-0.60.2-0.20.0-0.1-0.10.61.0-0.41.2
Locomotion distance, session 30.50.51.61.11.1-0.9-0.0-0.2-0.1-0.1-0.10.21.0-0.61.3
Stereotopy head waving bouts, day 31.21.43.4-1.40.21.11.21.41.41.21.21.50.31.8-0.4
Stereotopy head waving duration, day 30.50.61.4-0.80.60.40.80.90.90.50.51.20.51.20.1
Locomotion velocity, session 73.94.38.42.3-0.2-2.7-2.3-2.6-2.7-1.9-1.9-1.9-0.2-2.90.8
Locomotion distance, session 72.53.16.11.6-1.4-1.6-2.2-1.8-2.3-1.4-1.4-2.4-0.9-2.5-0.2
Stereotopy head waving bouts, day 71.01.23.3-1.21.0-0.11.01.31.20.70.71.70.61.8-0.0
Stereotopy head waving duration, day 71.21.43.5-0.71.9-0.21.21.21.30.60.61.81.21.50.9
Locomotion velocity, session 80.30.31.91.40.30.70.50.40.40.60.60.40.30.10.1
Locomotion distance, session 80.10.10.80.9-0.20.2-0.3-0.2-0.3-0.1-0.1-0.2-0.5-0.2-0.6
Degree of sensitization distance1.21.23.2-0.0-1.6-0.1-1.4-0.8-1.3-0.7-0.7-1.8-1.2-1.1-0.9
Degree of sensitization stereotypy0.60.61.6-0.61.3-0.40.60.80.80.30.31.20.81.00.5
Conditioned locomotion0.40.41.3-1.01.2-0.10.50.20.30.20.21.10.80.50.6
Cocaine response after cond. corrected0.91.03.30.20.01.81.11.21.31.01.00.70.11.4-0.3
Cocaine response after cond. not corrected0.30.30.9-0.3-0.00.90.60.70.80.30.30.2-0.10.9-0.3
Cocaine response before conditioning1.51.86.9-1.1-0.3-2.6-1.4-1.2-1.5-1.6-1.6-1.0-0.3-1.2-0.0
Saline control response0.30.41.20.00.20.41.00.40.40.80.81.1-0.10.9-0.3
Bone: connectivity density0.91.44.0-0.40.52.01.11.41.31.51.50.90.90.90.5
Bone: cortical apparent density0.30.42.41.5-0.90.20.2-0.0-0.0-0.1-0.10.2-0.70.1-0.7
Bone: cortical area3.35.18.40.9-1.9-1.6-2.9-2.9-2.7-2.2-2.2-2.8-1.8-2.8-0.9
Bone: cortical porosity2.72.95.9-1.6-2.4-0.6-1.8-1.9-1.7-1.0-1.0-1.7-2.2-1.3-2.1
Bone: cortical porosity3.63.96.2-1.4-2.5-1.1-2.2-2.4-2.3-1.3-1.3-2.1-2.4-1.8-2.1
Bone: cortical thickness1.93.15.81.3-1.4-1.4-2.1-2.4-2.2-1.6-1.6-2.1-1.1-2.3-0.3
Bone: cortical thickness1.41.73.70.1-1.4-1.2-1.4-1.9-1.7-1.1-1.1-1.4-1.3-1.3-0.8
Bone: cortical tissue density0.30.42.41.5-0.90.20.2-0.00.0-0.1-0.10.2-0.80.1-0.8
Condit. Reinf. active minus inactive responses1.61.84.51.4-0.4-0.7-1.4-1.4-1.6-1.3-1.3-2.1-0.6-2.10.2
Condit. Reinf. active-inactive response ratio0.30.41.51.20.30.5-0.2-0.2-0.3-0.5-0.5-0.9-0.1-0.90.2
Condit. Reinf. active responses2.32.96.50.6-0.6-1.6-2.0-1.9-2.2-1.7-1.7-2.5-0.7-2.50.2
Condit. Reinf. inactive responses1.11.43.0-0.9-0.9-1.7-1.5-1.1-1.5-0.9-0.9-1.5-0.5-1.3-0.1
Incentive salience index mean1.01.33.40.1-0.6-0.8-1.4-1.1-1.4-1.1-1.1-1.8-0.8-1.6-0.1
Condit. Reinf. lever presses0.40.54.1-2.0-0.5-0.7-0.7-0.1-0.5-0.3-0.3-0.6-0.50.0-0.5
Condit. Reinf. active minus inactive responses1.11.52.5-0.5-1.3-1.5-1.4-1.4-1.6-1.2-1.2-0.8-1.2-1.0-1.0
Condit. Reinf. active-inactive response ratio1.01.21.70.5-0.9-1.2-1.3-1.3-1.3-1.2-1.2-1.1-1.0-1.0-0.7
Condit. Reinf. active responses0.70.92.5-1.4-1.6-1.0-1.0-0.7-1.1-0.5-0.5-0.5-1.0-0.3-1.0
Condit. Reinf. inactive responses0.40.63.8-1.9-0.90.20.20.60.20.70.70.4-0.20.8-0.4
Condit. Reinf. lever presses2.12.97.0-2.6-1.4-2.1-1.9-1.6-1.9-1.7-1.7-1.1-1.6-0.8-1.3
Condit. Reinf. lever reinforcers received0.81.22.8-1.5-1.7-1.2-1.2-0.8-1.3-0.7-0.7-0.7-1.1-0.4-1.0
Conditioned reinforcement - actives0.81.33.50.10.00.40.81.80.91.91.90.41.41.01.1
Conditioned reinforcement - inactives0.60.91.91.0-0.1-1.4-1.0-1.1-1.2-0.9-0.9-0.90.0-1.30.7
Conditioned locomotion1.72.24.9-0.60.61.31.42.21.71.81.81.21.61.61.0
Patch foraging indifference point 0 sec0.20.42.8-1.7-0.6-1.3-0.2-0.0-0.3-0.0-0.00.0-0.30.2-0.4
Patch foraging indifference point AUC0.20.20.5-0.7-0.7-0.4-0.4-0.1-0.5-0.3-0.3-0.4-0.70.2-0.7
Delay disc. indifference point, 0s delay0.20.21.00.30.4-1.0-0.3-0.3-0.2-0.4-0.40.20.2-0.40.4
Delay disc. indifference point, 16s delay0.91.09.9-3.10.1-0.6-0.3-0.5-0.1-0.4-0.40.0-0.50.4-0.7
Delay disc. indifference point, 2s delay1.41.63.20.7-0.4-1.5-1.5-1.6-1.2-1.8-1.8-1.3-0.4-1.30.1
Delay disc. indifference point, 24s delay0.60.63.2-1.8-0.80.10.20.80.20.50.50.3-0.70.8-1.1
Delay disc. indifference point, 4s delay1.11.13.0-0.5-1.4-0.7-1.5-0.8-0.9-0.8-0.8-1.7-1.1-0.8-0.8
Delay disc. indifference point, 8s delay2.42.88.5-2.9-1.3-2.5-2.0-1.3-1.6-1.2-1.2-1.7-1.5-0.7-1.1
Indifference point function ln k0.10.10.6-0.20.8-0.20.2-0.2-0.0-0.3-0.30.50.10.00.0
Indifference point function log k0.10.10.6-0.20.8-0.20.2-0.2-0.0-0.3-0.30.50.10.00.0
Patch foraging total patch changes 0 sec0.30.62.8-1.7-0.8-1.5-0.4-0.2-0.5-0.2-0.2-0.2-0.50.1-0.6
Patch foraging total patch changes 12 sec0.50.62.2-0.7-1.5-1.5-0.8-0.4-0.8-0.3-0.3-0.8-0.4-0.4-0.3
Patch foraging total patch changes 18 sec1.01.52.7-1.4-0.30.51.11.61.41.61.60.91.01.50.6
Patch foraging total patch changes 24 sec0.10.21.1-1.00.1-0.50.00.20.00.10.10.10.80.10.7
Patch foraging total patch changes 6 sec0.20.20.9-1.0-0.7-0.9-0.3-0.0-0.6-0.0-0.0-0.3-0.2-0.1-0.1
Patch foraging time to switch 0 sec1.94.06.50.92.21.62.32.02.31.91.92.02.61.32.2
Patch foraging water rate 0 sec1.12.23.8-1.3-1.8-1.1-1.8-1.7-1.6-1.3-1.3-1.0-2.0-0.9-1.8
Patch foraging water rate 12 sec1.02.14.2-2.0-0.11.41.61.51.51.61.61.60.12.0-0.7
Patch foraging water rate 18 sec0.30.52.6-1.6-0.40.50.50.40.40.50.50.6-0.40.8-0.8
Patch foraging water rate 24 sec0.20.31.3-1.1-1.10.4-0.10.2-0.00.60.60.3-0.50.4-0.6
Patch foraging water rate 6 sec0.60.83.1-1.1-1.80.5-0.9-0.4-0.3-0.1-0.1-0.4-1.4-0.0-1.5
Seeking ratio, delayed vs. immediate footshock0.30.30.80.4-0.80.90.40.50.30.90.90.50.10.2-0.2
Distance traveled before self-admin1.72.26.30.80.42.51.91.11.91.41.42.10.31.4-0.4
Distance traveled after self-admin0.91.11.71.0-0.70.91.21.11.30.90.91.1-0.51.3-1.2
Extensor digitorum longus weight0.41.63.0-1.01.00.91.51.31.21.41.41.71.41.10.9
Bone: elastic displacement0.60.71.7-0.2-0.7-1.3-0.7-1.0-0.7-1.0-1.0-0.6-0.8-0.6-0.8
Bone: elastic work1.62.03.7-0.1-1.2-1.5-1.5-1.9-1.6-1.5-1.5-1.3-1.6-1.5-1.1
Bone: endosteal estimation0.20.51.8-1.3-1.00.2-0.3-0.0-0.2-0.3-0.3-0.1-1.20.1-1.4
Bone: endosteal perimeter0.71.63.2-0.7-1.4-0.7-1.4-1.3-1.1-1.4-1.4-1.1-1.8-0.9-1.5
Epididymis fat weight1.13.77.1-0.22.71.42.21.92.12.02.01.82.31.32.0
Delta time in closed arm before/after self-admin0.10.10.3-0.30.2-0.5-0.2-0.1-0.40.20.2-0.1-0.1-0.3-0.3
Delta time in open arm before/after self-admin0.40.41.40.2-0.51.20.2-0.30.5-0.7-0.70.2-0.90.3-1.0
Diff in mean of infusions in LGA sessions0.60.71.51.20.90.91.00.60.60.80.80.51.00.21.1
Delay discount exponential model param1.41.65.12.30.91.61.51.01.01.11.11.31.10.50.9
Extinction: sum of active levers before priming0.20.30.80.4-0.90.50.00.50.1-0.1-0.1-0.2-0.70.5-0.9
Active lever presses in extinction session 61.51.56.82.61.5-0.20.4-0.1-0.0-0.7-0.70.31.6-0.72.0
Bone: final force2.13.46.40.0-2.5-0.8-2.4-2.2-2.2-1.4-1.4-2.2-2.0-2.0-1.3
Bone: final moment2.43.86.90.1-2.6-1.1-2.5-2.4-2.4-1.5-1.5-2.3-2.0-2.1-1.3
Food consumed during 24 hour testing period0.81.13.01.3-0.3-1.2-1.1-1.7-1.3-0.8-0.8-0.4-0.0-1.60.4
Glucose1.52.46.40.5-2.5-0.6-1.9-1.5-1.5-1.0-1.0-2.0-1.9-1.3-1.4
Heart weight0.81.22.8-0.50.71.71.31.11.21.31.31.20.41.3-0.0
Delay discount hyperbolic model param1.51.73.31.80.91.71.71.11.11.31.31.51.10.70.8
Intermittent access intake day 1-15 change0.10.20.40.50.60.10.50.5-0.20.50.50.40.40.40.3
Intermittent access intake escalation0.10.30.90.90.6-0.10.40.5-0.40.60.60.30.50.30.5
Intermittent access intake escalation 20.20.21.01.00.80.20.20.2-0.50.20.20.20.4-0.00.5
Intermitt. access day 1 inactive lever presses0.10.51.7-1.1-0.20.20.50.20.5-0.0-0.00.9-0.91.1-1.3
Intermitt. access day 15 inactive lever presses0.40.81.50.3-0.3-1.2-1.0-1.1-1.0-1.0-1.0-0.8-0.8-0.9-0.5
Intermitt. access escalation Index0.50.72.4-1.60.40.80.80.51.00.20.20.9-0.31.1-0.7
Intermittent access day 1 total infusions0.20.42.21.1-1.5-0.3-0.6-0.0-0.00.10.1-0.8-0.2-0.5-0.1
Intermittent access day 15 total infusions0.30.53.41.8-0.8-0.3-0.50.0-0.50.40.4-0.80.1-0.50.3
Intermittent access terminal intake (last 3 days)0.30.42.21.5-0.9-0.2-0.6-0.2-0.50.10.1-0.8-0.3-0.6-0.1
Intermittent access total infusions0.70.82.51.4-1.6-0.5-1.1-0.4-0.60.00.0-1.4-0.4-1.0-0.1
Intermittent access day 1 locomotion0.20.31.81.2-1.3-0.2-0.20.2-0.1-0.1-0.1-0.3-0.4-0.0-0.4
Intermittent access day 15 total locomotion0.10.20.70.4-0.50.10.40.90.30.30.30.40.00.6-0.4
Intermittent access total locomotion0.40.52.51.1-1.6-0.1-0.40.1-0.30.00.0-0.6-0.8-0.2-0.9
Intermittent access standard deviation0.51.06.42.5-0.7-0.6-0.9-0.2-0.8-0.6-0.6-1.20.0-1.00.6
Left kidney weight1.35.911.1-2.50.33.32.32.92.73.33.32.11.12.40.4
Right kidney weight1.15.18.4-2.50.52.92.22.82.52.92.92.01.02.40.4
Cocaine induced anxiety0.91.33.7-1.90.9-1.3-0.6-1.5-0.3-1.6-1.6-0.1-0.9-0.7-0.4
Post-drug Anxiety1.41.53.7-1.00.6-1.5-1.0-1.8-0.8-1.9-1.9-0.5-0.8-1.1-0.4
Baseline Anxiety0.30.41.31.1-0.7-0.5-0.7-0.3-0.9-0.4-0.4-0.7-0.1-0.6-0.3
Tail length0.00.10.4-0.10.2-0.6-0.4-0.3-0.6-0.3-0.30.0-0.3-0.50.0
Length with tail0.10.41.51.00.6-0.10.00.1-0.50.40.40.10.7-0.71.2
Length without tail0.30.82.51.00.61.00.70.50.51.01.00.41.3-0.01.6
Times rat made contact with spout0.60.72.1-0.10.4-1.5-0.5-1.2-1.0-0.9-0.90.30.3-0.90.6
Lifetime Intake0.30.31.30.8-1.1-0.0-0.40.30.00.80.8-0.70.2-0.30.4
Liver weight, left0.50.72.11.4-1.30.7-0.9-0.7-0.8-0.1-0.1-1.0-0.8-1.0-0.3
Liver weight, right0.61.13.81.00.11.90.50.60.61.61.6-0.20.8-0.21.0
Locomotor activity0.20.31.2-0.71.1-0.70.3-0.20.2-0.2-0.20.40.7-0.00.9
Locomotor testing distance0.20.42.40.50.5-1.5-0.2-0.6-0.4-0.7-0.7-0.20.4-0.50.6
Locomotor testing rearing0.71.53.60.41.4-0.51.41.11.11.01.01.41.90.71.7
Locomotion in novel chamber0.81.13.10.4-1.8-1.2-1.3-0.8-1.2-0.4-0.4-1.4-0.8-0.9-0.5
Locomotion in novel chamber post-restriction1.32.18.41.4-2.90.0-1.2-0.9-1.1-0.9-0.9-1.2-2.1-0.7-1.8
Fecal boli incidents, locomotor time 11.52.24.80.30.7-2.2-1.4-1.5-1.4-1.9-1.9-1.50.2-2.10.9
Change in fecal boli incidents, locomotor task1.21.24.61.1-1.42.20.71.00.51.51.50.1-0.30.6-0.6
Time >=10cm from walls, locomotor time 10.30.41.3-0.2-0.20.80.40.50.41.11.10.60.00.4-0.2
Bouts of movement, locomotor time 12.12.34.2-1.2-1.4-1.9-2.0-1.4-1.9-1.5-1.5-1.9-1.1-1.2-0.7
Total resting periods, locomotor time 11.11.32.9-0.9-1.1-1.3-1.6-0.9-1.4-1.0-1.0-1.7-0.6-1.0-0.2
Rest time, locomotor task time 12.32.95.90.81.01.91.62.31.61.91.90.72.40.92.3
Distance moved, locomotor task time 11.01.44.20.3-0.9-0.8-0.8-1.5-1.1-1.4-1.4-0.2-1.9-0.3-2.0
Vertical activity count, locomotor time 10.71.83.6-0.1-1.1-1.0-1.2-1.9-1.7-1.4-1.4-0.4-1.9-0.5-1.9
Time >=10cm from walls, locomotor time 20.10.20.70.6-0.80.2-0.10.1-0.40.40.4-0.1-0.40.1-0.6
Bouts of movement, locomotor time 20.60.94.9-2.2-1.1-1.0-0.8-0.2-0.5-0.4-0.4-0.3-1.00.3-1.2
Total resting periods, locomotor time 20.40.74.0-2.0-0.9-0.8-0.5-0.0-0.3-0.3-0.3-0.0-0.90.6-1.1
Rest time, locomotor task time 20.81.02.5-0.1-0.61.60.91.51.21.31.30.50.50.90.0
Distance moved, locomotor task time 21.41.73.30.9-1.1-1.2-1.2-1.5-1.5-1.4-1.4-0.7-1.8-0.6-1.7
Vertical activity count, locomotor time 20.30.40.90.70.0-0.7-0.5-1.0-0.9-0.6-0.6-0.2-0.6-0.4-0.4
Light reinforcement 10.20.50.9-0.0-0.9-0.9-0.7-0.8-0.6-0.8-0.8-0.6-0.9-0.3-0.7
Light reinforcement 20.20.31.10.5-1.00.4-0.5-0.4-0.1-0.1-0.1-1.0-0.8-0.4-0.6
Bone: marrow area0.20.51.8-1.2-1.00.1-0.4-0.1-0.3-0.4-0.4-0.1-1.20.0-1.3
Bone: maximum diameter2.95.38.7-0.2-2.1-1.7-2.9-2.9-2.8-2.4-2.4-2.5-2.2-2.7-1.3
Bone: maximum force1.01.83.80.4-1.9-0.5-1.7-1.5-1.7-0.8-0.8-1.5-1.4-1.6-0.9
Bone: maximum moment1.22.14.10.4-2.0-0.8-1.9-1.7-1.9-0.9-0.9-1.6-1.5-1.7-1.0
Mean time between licks in bursts0.30.92.0-0.40.21.40.91.21.11.01.00.60.11.4-0.2
Mean num. licks in bursts2.33.66.40.1-1.4-1.6-2.5-2.4-2.4-2.1-2.1-2.1-1.5-2.2-0.8
Cd content in liver0.20.30.7-0.30.7-0.8-0.2-0.6-0.4-0.8-0.80.3-0.1-0.0-0.1
Co content in liver0.40.53.6-1.9-0.5-0.7-0.4-0.4-0.4-0.3-0.3-0.3-0.5-0.0-0.7
Cu content in liver0.20.20.6-0.50.8-0.30.40.30.30.30.30.40.80.10.6
Fe content in liver2.02.45.20.42.30.71.71.41.51.11.12.31.91.51.6
K content in liver0.30.32.8-1.70.1-0.50.10.0-0.00.00.00.4-0.30.2-0.3
Mg content in liver0.50.61.1-1.01.0-0.00.80.50.50.70.70.71.00.50.9
Mn content in liver1.31.47.8-2.80.40.61.01.11.20.90.91.10.41.4-0.0
Na content in liver0.40.40.90.70.3-1.0-0.5-1.0-0.7-0.7-0.70.10.2-0.60.6
Rb content in liver0.60.82.01.30.8-0.8-0.4-0.6-0.7-0.2-0.2-0.80.9-1.21.4
Se content in liver0.10.10.6-0.20.4-0.20.20.30.20.20.20.80.60.40.4
Sr content in liver0.90.84.0-2.0-0.40.90.40.60.70.50.50.6-0.61.1-1.1
Zn content in liver1.11.22.5-1.60.90.41.11.10.91.21.21.11.31.10.8
Bone: minimum diameter1.12.04.40.5-1.7-0.5-1.5-1.3-1.3-1.2-1.2-1.4-2.1-1.1-1.9
Time in familiar zone, hab. session 10.80.84.1-0.0-2.00.6-0.70.5-0.30.20.2-0.6-1.2-0.0-1.4
Time in novel zone, hab. session 10.50.51.60.41.0-0.60.3-0.10.00.30.30.21.2-0.61.3
Total zone transitions, hab. session 10.71.02.71.6-1.61.30.31.00.31.21.2-0.5-0.50.1-0.8
Total locomotion distance, hab. session 10.71.03.70.9-1.90.5-0.6-0.2-0.5-0.0-0.0-1.0-1.6-0.4-1.5
Locomotion velocity, hab. session 10.50.72.80.9-1.70.7-0.40.1-0.30.10.1-0.8-1.4-0.2-1.3
Time in familiar zone, hab. session 20.30.31.1-1.00.10.60.40.70.60.60.60.50.20.6-0.1
Time in novel zone, hab. session 20.20.22.11.5-0.3-0.2-0.10.1-0.1-0.0-0.0-0.20.2-0.40.2
Total zone transitions, hab. session 20.70.94.02.0-1.40.9-0.00.50.11.21.2-0.9-0.2-0.4-0.3
Total locomotion distance, hab. session 20.91.24.81.7-2.20.3-0.9-0.5-0.60.20.2-1.1-1.2-0.7-1.2
Locomotion velocity, hab. session 20.60.93.91.4-2.00.5-0.7-0.2-0.30.40.4-0.8-1.0-0.4-1.1
Novel to familiar place preference ratio0.20.20.6-0.6-0.6-0.8-0.2-0.7-0.50.00.00.2-0.2-0.2-0.3
Novelty place preference0.20.20.6-0.7-0.5-0.8-0.2-0.6-0.5-0.0-0.00.2-0.1-0.3-0.2
Time in novel zone, NPP test0.20.20.7-0.4-0.7-0.8-0.4-0.7-0.6-0.0-0.0-0.1-0.2-0.5-0.3
Total zone transitions, NPP test0.40.52.71.6-0.90.80.10.40.10.90.9-0.60.1-0.30.1
Total locomotion distance, NPP test0.20.31.51.2-0.90.2-0.3-0.0-0.20.30.3-0.6-0.0-0.60.1
Locomotion velocity, NPP test0.10.10.60.8-0.60.2-0.3-0.2-0.10.30.3-0.40.0-0.40.2
Intraocular pressure0.50.82.1-0.4-0.21.40.61.01.01.41.40.30.30.7-0.1
Delta distance traveled before/after self-admin0.30.31.1-0.7-0.8-0.7-0.10.40.0-0.1-0.1-0.3-0.70.7-1.1
Delta ambulatory time before/after self-admin0.81.02.4-0.6-1.6-1.1-0.9-0.3-0.7-0.8-0.8-0.9-1.40.1-1.5
Parametrial fat weight0.30.61.40.3-0.7-0.3-0.9-1.0-1.2-0.5-0.5-1.0-0.8-0.9-0.5
Pavlov. Cond. lever latency1.62.03.81.31.50.71.41.61.31.41.41.52.00.51.8
Pavlov. Cond. magazine entry latency1.82.47.8-1.0-2.1-0.0-1.3-1.0-0.9-1.2-1.2-1.5-2.5-0.1-2.8
Pavlov. Cond. change in total contacts2.83.07.7-1.1-2.8-0.7-1.7-1.1-1.3-1.0-1.0-1.9-2.6-0.5-2.7
Pavlov. Cond. index score1.82.25.2-0.8-1.8-0.3-1.5-1.3-1.2-1.4-1.4-1.7-2.2-0.5-2.3
Pavlov. Cond. latency score2.12.75.0-0.9-1.7-0.8-1.8-1.7-1.5-1.7-1.7-1.8-2.2-0.7-2.1
Pavlov. Cond. lever contacts1.62.04.1-1.3-1.7-0.5-1.5-1.3-1.3-1.2-1.2-1.5-2.0-0.5-2.0
Pavlov. Cond. magazine entry number2.22.89.30.42.5-0.11.51.21.01.21.21.72.80.33.0
Pavlov. Cond. intertrial magazine entries1.92.28.32.91.90.30.50.30.40.30.30.02.2-1.02.9
Pavlov. Cond. lever-magazine prob. diff.1.62.05.9-0.8-2.0-0.0-1.3-1.0-0.9-1.1-1.1-1.5-2.3-0.2-2.4
Pavlov. Cond. response bias2.43.010.0-0.9-2.80.2-1.4-1.1-1.0-1.0-1.0-1.7-2.9-0.2-3.2
Pavlov. Cond. lever latency1.72.310.33.21.71.11.20.80.91.01.00.52.0-0.22.1
Pavlov. Cond. magazine entry latency0.70.91.5-1.0-0.7-1.1-1.0-0.6-0.9-1.2-1.2-0.2-1.1-0.3-1.0
Pavlov. Cond. change in total contacts1.32.13.5-1.7-1.6-1.4-1.5-1.2-1.3-1.5-1.5-0.9-1.9-0.5-1.8
Pavlov. Cond. index score1.41.95.9-2.4-1.6-1.1-1.3-0.8-1.0-1.2-1.2-0.6-1.8-0.1-1.7
Pavlov. Cond. latency score1.41.85.4-2.3-1.6-1.2-1.3-0.8-1.1-1.1-1.1-0.6-1.7-0.2-1.7
Pavlov. Cond. lever contacts1.92.611.1-3.3-1.9-1.0-1.3-0.8-0.9-1.1-1.1-0.5-2.20.3-2.4
Pavlov. Cond. magazine entry number0.81.01.60.81.00.91.30.71.21.11.10.81.10.80.9
Pavlov. Cond. intertrial magazine entries0.30.40.90.50.0-0.4-0.7-0.5-0.9-0.6-0.6-0.80.2-0.90.6
Pavlov. Cond. lever-magazine prob. diff.1.31.84.7-2.2-1.6-1.0-1.3-0.8-1.0-1.2-1.2-0.7-1.8-0.2-1.7
Pavlov. Cond. response bias1.82.46.5-2.6-1.9-0.9-1.4-1.0-1.1-1.3-1.3-0.7-2.2-0.0-2.2
Time in closed arm before self-admin0.20.21.4-0.31.20.20.40.00.4-0.2-0.20.10.7-0.10.8
Time in closed arm after self-admin0.10.10.6-0.40.80.30.50.40.30.30.30.30.20.30.0
Time in open arm before self-admin0.70.83.61.9-1.8-0.3-0.6-0.2-0.80.30.3-0.6-0.5-0.3-0.5
Time in open arm after self-admin0.30.31.50.3-1.20.6-0.2-0.20.2-0.3-0.30.2-0.70.4-0.9
Bone: periosteal estimation1.43.04.5-0.2-2.0-0.9-2.1-1.9-1.9-1.7-1.7-1.9-2.1-1.8-1.6
Bone: periosteal perimeter1.32.33.8-0.3-1.4-1.0-1.9-1.9-1.6-1.6-1.6-1.8-1.5-1.7-0.9
Bone: post-yield work0.30.41.90.5-1.40.7-0.40.3-0.40.20.2-0.3-0.9-0.1-1.0
Progressive ratio test 1 active lever presses0.30.41.1-0.1-1.10.50.30.60.80.80.80.2-0.10.5-0.5
Progressive ratio test 1 breakpoint0.30.31.1-0.0-1.10.50.20.60.70.70.70.2-0.20.5-0.5
Progressive ratio test 1 inactive lever presses1.11.54.02.0-1.3-1.3-1.2-1.1-1.0-1.4-1.4-1.2-0.6-1.3-0.2
Progressive ratio test 2 active lever presses0.20.30.80.4-0.6-0.1-0.10.7-0.00.90.9-0.40.40.00.5
Progressive ratio test 2 breakpoint0.20.20.50.6-0.6-0.2-0.20.5-0.20.70.7-0.60.3-0.10.5
Progressive ratio test 2 inactive lever presses1.21.95.42.3-0.8-1.6-1.5-1.2-1.6-1.0-1.0-1.7-0.1-1.70.6
Incentive Sensitization - Responses0.50.71.81.20.1-1.4-0.8-0.4-1.1-0.1-0.1-1.10.4-1.01.0
Incentive Sensitization - Breakpoint0.50.71.71.10.2-1.3-0.8-0.4-1.1-0.2-0.2-1.10.4-1.01.0
Sum of active levers in priming session hrs 5-61.41.34.62.1-0.3-0.6-0.9-1.3-1.2-1.4-1.4-0.7-0.4-1.50.1
Progressive ratio0.30.52.8-1.7-0.10.60.20.60.41.01.0-0.10.30.30.1
Food seeking constrained by brief footshock0.30.41.70.80.50.40.20.50.50.50.5-0.31.1-0.21.3
Seeking ratio, punishment vs. effort0.20.32.51.60.70.00.40.20.3-0.1-0.10.40.50.10.6
Retroperitoneal fat weight0.83.66.1-0.22.32.52.31.61.92.02.02.01.91.51.5
Reaction time number correct1.12.26.61.2-0.3-2.6-1.5-1.7-1.7-1.7-1.7-1.0-0.4-1.70.1
Reaction time mean minus median0.20.53.00.7-0.11.70.70.30.70.70.70.6-0.10.4-0.2
Reaction time mean minus median AUC0.10.31.00.3-0.21.00.60.10.50.30.30.8-0.60.6-0.9
Reaction time num false alarms0.81.24.4-2.1-1.6-1.1-1.1-0.6-0.8-0.4-0.4-0.4-1.40.1-1.2
Reaction time num false alarms AUC0.81.34.9-2.2-1.6-1.3-1.1-0.6-0.9-0.3-0.3-0.4-1.30.1-1.2
Reaction time trials correct on left1.12.26.61.2-0.3-2.6-1.5-1.7-1.7-1.7-1.7-1.0-0.4-1.70.1
Reaction time trials on left1.12.06.11.3-0.3-2.5-1.4-1.6-1.6-1.6-1.6-1.0-0.3-1.60.2
Reaction time mean0.61.05.4-0.10.62.30.91.11.40.80.80.60.40.90.2
Reaction time mean AUC0.61.04.80.10.62.21.01.11.40.80.80.70.31.00.0
Median of all reaction times0.81.15.3-0.40.72.30.91.21.50.80.80.50.41.00.3
Reaction time omissions0.40.51.80.90.21.40.80.50.80.90.90.40.30.50.2
Reaction time false alarm rate0.81.16.8-2.6-1.40.1-0.30.2-0.00.40.40.1-1.20.9-1.3
Reaction time premature initiation rate1.21.73.5-0.70.6-1.6-1.1-1.9-1.5-1.9-1.9-0.5-0.3-1.40.3
Reaction time premature initiations2.03.57.90.00.3-2.8-1.8-2.5-2.2-2.6-2.6-1.0-0.5-2.20.3
Std. dev. reaction times0.30.52.80.2-0.21.70.60.60.90.60.60.6-0.20.7-0.4
Reaction time trials completed1.12.06.11.3-0.3-2.5-1.4-1.6-1.6-1.6-1.6-1.0-0.3-1.60.2
Reaction time trials AUC1.01.95.61.1-0.3-2.4-1.4-1.6-1.5-1.6-1.6-0.9-0.3-1.60.2
Run reversals in cocaine runway, females0.70.71.9-0.80.21.40.81.01.10.80.80.60.21.1-0.3
Run reversals in cocaine runway, males0.80.82.20.11.20.00.90.80.90.70.71.51.10.90.8
Latency to leave start box in cocaine runway1.21.32.70.3-1.21.41.11.31.01.61.60.9-0.41.4-0.8
Latency to leave start box in cocaine runway, F1.01.13.50.1-0.21.91.20.91.01.41.41.0-0.01.1-0.3
Latency to leave start box in cocaine runway, M1.31.22.7-0.2-1.60.20.91.60.91.41.40.8-0.31.5-0.9
Std. dev. time between licks in bursts0.10.20.4-0.10.60.30.40.50.40.50.50.60.30.40.1
Total sessions with >9 infusions0.30.32.20.6-1.50.2-0.20.40.10.70.7-0.3-0.30.1-0.3
Short access day 1 total inactive lever presses0.20.31.01.0-0.3-0.5-0.4-0.4-0.4-0.4-0.4-0.50.1-0.70.5
Short access day 10 total inactive lever presses0.51.32.90.60.0-1.2-1.1-1.5-1.2-1.7-1.7-1.0-0.8-1.3-0.1
Short access day 1 total infusions0.20.30.80.6-0.90.0-0.10.60.00.80.8-0.30.5-0.10.7
Short access day 10 total infusions0.20.30.90.5-0.80.00.20.70.61.01.00.10.20.30.1
Short access total infusions0.40.42.00.4-1.40.2-0.00.70.31.11.1-0.30.10.20.1
Short access day 1 locomotion2.53.17.4-0.4-0.61.61.72.71.62.72.71.50.82.20.2
Short access day 10 total locomotion0.20.41.71.2-1.3-0.2-0.00.6-0.2-0.1-0.10.0-0.70.5-0.9
Short access total locomotion0.50.63.21.4-1.80.2-0.10.70.10.40.4-0.1-0.60.4-0.7
One hour access (0.3 mA shock)0.10.10.5-0.1-0.00.20.10.50.10.70.7-0.20.30.10.3
Compulsive drug intake0.20.21.30.11.10.10.5-0.10.0-0.4-0.40.70.30.30.4
One hour access (shock baseline)0.10.20.50.2-0.30.00.00.50.30.70.7-0.30.4-0.00.3
Social response proportion0.60.72.00.7-0.8-0.9-1.0-0.7-1.1-0.2-0.2-1.4-0.2-1.20.1
Social responses0.91.22.1-1.3-1.2-1.4-1.3-1.0-1.4-0.6-0.6-1.3-0.8-1.1-0.5
Social time0.30.42.4-1.51.2-0.20.4-0.10.1-0.1-0.1-0.10.60.00.7
Soleus weight0.30.93.7-1.40.70.41.10.80.80.60.61.90.61.10.3
Bone: stiffness0.20.30.80.3-0.90.6-0.7-0.3-0.50.20.2-0.6-0.1-0.70.3
Tibialis anterior weight5.217.627.5-2.43.44.05.05.04.84.44.45.23.44.91.7
Time to tail flick, vehicle, before self-admin4.95.17.3-2.12.42.12.42.32.52.72.72.12.21.71.6
Time to tail flick, vehicle, after self-admin1.72.26.8-1.92.60.91.51.31.30.90.91.31.71.31.3
Time to tail flick, test, before self-admin0.70.73.5-0.31.1-0.2-0.00.0-0.00.60.6-0.11.5-0.71.9
Time to tail flick, test, after self-admin0.40.41.0-0.70.5-0.6-0.6-0.4-0.9-0.3-0.3-0.50.5-0.71.0
Delta time to tail flick, vehicle, before/after SA1.41.43.8-0.20.4-2.0-1.1-1.2-1.2-1.8-1.8-0.9-0.2-0.90.2
Delta time to tail flick, test, before/after SA0.40.40.9-0.7-0.1-0.6-0.4-0.4-0.6-0.9-0.9-0.1-0.80.1-0.8
Tibia length1.64.38.11.3-1.0-1.9-2.6-2.6-2.6-2.3-2.3-2.2-1.1-2.8-0.1
Ambulatory time before self-admin1.52.25.10.90.32.32.01.51.91.41.42.00.31.7-0.4
Ambulatory time after self-admin0.91.02.70.4-0.91.00.90.91.10.50.50.9-1.01.4-1.7
Bone: tissue strength0.50.51.21.0-1.10.9-0.10.40.10.90.9-0.0-0.40.1-0.8
Total heroin consumption0.30.41.70.40.61.30.80.40.70.30.30.70.00.5-0.2
Bone: trabecular number1.52.46.8-0.6-0.02.61.52.11.82.02.00.90.61.6-0.0
Bone: trabecular spacing0.50.61.51.20.3-1.1-0.6-1.0-0.7-0.8-0.8-0.70.2-0.70.7
Bone: trabecular thickness1.51.95.4-2.1-1.12.30.71.21.41.31.30.8-0.61.5-1.1
Bone: trabecular tissue density0.00.00.10.20.10.10.0-0.00.40.10.10.30.00.30.0
Water consumed over 24 hours0.20.31.1-0.6-0.1-1.0-0.4-0.9-0.6-0.4-0.40.70.2-0.50.1
Number of responses in last shaping day0.30.31.4-0.10.60.60.00.50.50.20.2-0.20.8-0.21.2