Hub : Genes

Wnt7b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Wnt7b	0.04	0.03	2.8e-03	0.03	0.02	0.02	0.02	6.1e-04	1.5e-03	2.7e-03	1.4e-03
2	Brain	mRNA stability	Wnt7b	0.03	0.02	9.2e-04	0.02	0.03	0.02	-0	8.1e-03	2.2e-03	9.8e-03	6.5e-01
3	Brain	alternative TSS	NM_001009695.2	0.03	0.02	1.8e-03	0.01	0.02	0.02	0.03	1.4e-02	2.4e-03	2.4e-03	1.4e-03
4	Brain	alternative TSS	NM_001412610.1	0.03	0.02	2.2e-03	0.02	0.02	0.02	0.03	8.8e-03	3.0e-03	2.7e-03	1.9e-03
5	Brain	alternative TSS	NM_001009695.2	0.04	0.02	1.4e-03	0.02	0.02	0.03	0.03	2.8e-03	2.4e-03	8.7e-04	6.0e-04
6	Brain	isoform ratio	NM_001009695.2	0.03	0.02	1.6e-03	0.02	0.03	0.03	0.04	3.5e-03	7.5e-04	1.0e-03	1.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.9	1.4	1.8	1.3	-1.2	1.2	-1.2	1.3	0.9
Area under the delay curve	2.2	2.3	5.6	2.4	-2.1	1.1	-1.1	1.1	0.7
BMI with tail	3.3	10.8	12.4	-3.5	3.2	-3.3	3.3	-3.1	-3.3
BMI without tail	1.7	3.4	3.8	-1.8	1.7	-2.0	1.9	-1.8	-1.9
Body weight	1.4	6.0	11.1	-3.3	2.6	-2.2	2.2	-2.2	-1.9
Weight adjusted by age	1.7	2.0	5.1	-2.3	1.7	-1.0	1.0	-1.0	-1.1
Bone surface	0.3	0.4	0.6	0.5	-0.8	0.7	-0.7	0.8	0.4
Bone volume	0.4	0.7	1.0	1.0	-1.0	0.8	-0.8	0.9	0.6
Breakpoint value in progressive ratio session	0.1	0.1	0.1	0.2	0.4	-0.1	0.1	-0.2	-0.4
Number of licking bursts	0.9	1.0	1.4	0.5	-1.0	1.1	-1.1	1.2	0.9
Context. condit. distance diff. score	1.8	2.1	2.9	-1.0	1.7	-1.7	1.7	-1.7	-0.8
Locomotion velocity, session 1	0.3	0.3	0.5	-0.7	0.6	-0.5	0.5	-0.6	-0.1
Locomotion distance, session 1	0.4	0.6	1.2	0.6	-0.7	0.7	-0.7	0.6	1.1
Locomotion velocity, session 2	2.0	2.3	3.3	-1.8	1.4	-1.5	1.5	-1.5	-1.4
Locomotion distance, session 2	0.1	0.1	0.5	0.7	-0.2	0.0	-0.0	0.0	-0.2
Locomotion velocity, session 3	1.0	1.1	1.9	-0.9	0.9	-1.2	1.2	-1.4	-0.4
Locomotion distance, session 3	0.2	0.2	0.6	0.3	-0.3	0.4	-0.4	0.4	0.8
Stereotopy head waving bouts, day 3	2.1	2.5	3.4	-0.7	1.3	-1.8	1.8	-1.8	-1.6
Stereotopy head waving duration, day 3	3.2	3.8	4.6	-1.2	2.0	-2.1	2.1	-2.1	-1.9
Locomotion velocity, session 7	1.2	1.3	1.7	-0.9	1.1	-1.3	1.3	-1.3	-1.0
Locomotion distance, session 7	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.2	-0.1	0.2
Stereotopy head waving bouts, day 7	1.5	1.7	2.8	-0.8	1.7	-1.4	1.4	-1.3	-1.1
Stereotopy head waving duration, day 7	0.5	0.6	1.1	-0.4	1.1	-0.8	0.8	-0.8	-0.7
Locomotion velocity, session 8	6.0	7.2	8.4	-2.3	2.9	-2.8	2.8	-2.7	-2.6
Locomotion distance, session 8	0.7	1.0	1.4	-0.6	1.1	-1.2	1.2	-1.1	-0.5
Degree of sensitization distance	1.4	1.4	1.7	-1.1	0.9	-1.3	1.3	-1.3	-1.2
Degree of sensitization stereotypy	0.5	0.6	1.2	-0.7	1.1	-0.8	0.7	-0.7	-0.6
Conditioned locomotion	0.0	0.0	0.1	-0.2	0.2	0.0	-0.0	-0.1	0.1
Cocaine response after cond. corrected	0.5	0.5	1.0	-0.4	-0.5	0.8	-0.8	1.0	0.7
Cocaine response after cond. not corrected	0.9	1.0	1.7	-0.1	-0.7	1.1	-1.1	1.3	1.1
Cocaine response before conditioning	0.3	0.4	0.5	0.7	-0.6	0.6	-0.6	0.5	0.7
Saline control response	0.8	1.0	2.2	-0.6	-0.1	1.1	-1.1	1.1	1.5
Bone: connectivity density	0.5	0.8	1.1	0.9	-1.0	0.9	-0.9	1.0	0.6
Bone: cortical apparent density	0.4	0.6	1.3	1.1	-1.0	0.6	-0.6	0.3	0.6
Bone: cortical area	1.0	1.5	3.6	-1.9	1.4	-0.9	0.9	-0.8	-1.0
Bone: cortical porosity	0.6	0.7	1.7	-1.3	0.8	-0.7	0.6	-0.5	-0.8
Bone: cortical porosity	0.7	0.7	1.6	-1.3	0.9	-0.7	0.7	-0.5	-0.8
Bone: cortical thickness	0.0	0.1	0.3	-0.5	0.1	0.1	-0.1	-0.0	-0.2
Bone: cortical thickness	1.6	1.8	3.3	-1.8	1.5	-1.1	1.1	-1.2	-1.2
Bone: cortical tissue density	0.3	0.4	1.0	1.0	-0.9	0.5	-0.4	0.2	0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	1.0	0.3	-1.0	0.8	-0.8	0.8	0.6
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.5	1.0	-1.2	1.0	-1.0	0.9	0.9
Condit. Reinf. active responses	1.3	1.6	2.6	1.1	-1.6	1.3	-1.3	1.2	1.2
Condit. Reinf. inactive responses	0.5	0.6	0.9	0.8	-1.0	0.7	-0.7	0.6	0.9
Incentive salience index mean	0.5	0.6	0.7	-0.4	-0.8	0.8	-0.8	0.8	0.8
Condit. Reinf. lever presses	0.3	0.4	1.4	-1.2	-0.2	0.5	-0.5	0.4	0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	-0.7	0.5	-0.5	0.5	-0.4	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.1	0.1	-0.1	0.3	-0.2
Condit. Reinf. active responses	1.5	2.1	2.3	-1.5	1.4	-1.4	1.4	-1.4	-1.5
Condit. Reinf. inactive responses	3.0	3.7	4.3	-1.7	1.9	-2.0	2.0	-2.1	-1.8
Condit. Reinf. lever presses	0.8	1.1	1.4	-1.0	1.2	-1.1	1.1	-1.0	-1.0
Condit. Reinf. lever reinforcers received	1.0	1.4	1.7	-1.3	1.1	-1.1	1.1	-1.1	-1.3
Conditioned reinforcement - actives	1.2	1.2	2.3	0.5	-1.0	1.2	-1.1	1.0	1.5
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.4	0.3	0.0	-0.0	0.1	0.5
Conditioned locomotion	0.4	0.4	1.6	-1.3	0.9	-0.2	0.2	-0.2	-0.2
Patch foraging indifference point 0 sec	0.3	0.4	0.7	0.3	-0.5	0.8	-0.8	0.9	0.2
Patch foraging indifference point AUC	0.1	0.1	0.2	0.3	-0.5	0.4	-0.3	0.1	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.3	-0.4	-0.5
Delay disc. indifference point, 16s delay	3.0	3.0	4.5	2.1	-2.1	1.6	-1.6	1.6	1.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.8	0.6	-0.9	0.2	-0.1	0.1	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	-0.0	-0.2	0.2	-0.1	-0.5
Delay disc. indifference point, 4s delay	1.6	1.7	5.3	2.3	-1.9	0.7	-0.7	0.6	0.1
Delay disc. indifference point, 8s delay	2.0	2.1	6.3	2.5	-1.7	1.0	-1.0	1.0	0.6
Indifference point function ln k	0.9	1.3	2.8	-1.7	1.6	-0.8	0.8	-0.8	-0.5
Indifference point function log k	0.9	1.3	2.8	-1.7	1.6	-0.8	0.8	-0.8	-0.5
Patch foraging total patch changes 0 sec	0.5	0.8	1.2	0.7	-0.7	1.1	-1.1	1.1	0.5
Patch foraging total patch changes 12 sec	0.1	0.1	0.4	-0.1	0.1	-0.4	0.4	-0.4	-0.6
Patch foraging total patch changes 18 sec	1.1	1.4	1.8	0.7	-1.3	1.3	-1.3	1.3	0.9
Patch foraging total patch changes 24 sec	0.2	0.3	0.9	1.0	-0.2	0.5	-0.5	0.4	0.3
Patch foraging total patch changes 6 sec	0.5	0.7	1.0	0.8	-0.9	1.0	-1.0	1.0	0.3
Patch foraging time to switch 0 sec	0.3	0.4	0.8	0.2	0.2	-0.8	0.8	-0.6	-0.9
Patch foraging water rate 0 sec	0.1	0.2	0.6	-0.7	0.8	-0.2	0.2	-0.2	-0.4
Patch foraging water rate 12 sec	0.4	0.7	1.1	-0.4	-0.0	0.9	-1.0	1.0	0.9
Patch foraging water rate 18 sec	0.2	0.3	0.6	-0.2	-0.1	0.7	-0.7	0.7	0.5
Patch foraging water rate 24 sec	0.2	0.3	0.6	-0.7	0.7	-0.4	0.4	-0.2	-0.3
Patch foraging water rate 6 sec	0.5	0.7	1.3	-0.1	-0.7	1.0	-0.9	0.8	1.2
Seeking ratio, delayed vs. immediate footshock	0.9	1.0	1.3	1.1	-0.9	1.1	-1.1	1.1	0.6
Distance traveled before self-admin	0.1	0.2	0.3	-0.2	0.1	-0.5	0.5	-0.5	-0.2
Distance traveled after self-admin	0.7	0.8	1.9	-1.4	1.1	-0.6	0.6	-0.5	-0.7
Extensor digitorum longus weight	0.2	1.0	1.7	-1.3	1.3	-0.9	0.8	-0.7	-0.7
Bone: elastic displacement	0.2	0.2	0.8	-0.9	0.3	0.3	-0.3	0.3	0.4
Bone: elastic work	2.9	3.8	5.7	-2.4	2.3	-1.7	1.7	-1.5	-1.8
Bone: endosteal estimation	1.9	4.1	6.0	-1.9	2.5	-2.1	2.1	-1.8	-1.8
Bone: endosteal perimeter	1.8	3.8	6.6	-2.6	2.6	-1.7	1.6	-1.4	-1.5
Epididymis fat weight	0.1	0.2	0.9	-1.0	0.3	0.0	0.0	-0.1	0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.3	0.1	-0.3	0.3	-0.3	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.6	0.2	-0.0	0.1	-0.2	0.2	0.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.3	0.1	-0.1	0.1	-0.2	-0.3
Delay discount exponential model param	2.3	2.4	6.0	-2.5	2.1	-1.1	1.0	-1.0	-0.7
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.5	-0.4	0.3	-0.3	0.1	-0.1
Active lever presses in extinction session 6	1.8	1.8	2.5	-0.9	1.1	-1.4	1.4	-1.4	-1.6
Bone: final force	1.3	2.1	2.8	-1.1	1.4	-1.5	1.5	-1.5	-1.7
Bone: final moment	1.7	2.8	3.7	-1.4	1.6	-1.7	1.7	-1.7	-1.9
Food consumed during 24 hour testing period	3.3	4.0	6.4	-2.5	2.2	-1.8	1.8	-1.8	-1.6
Glucose	0.2	0.3	0.5	-0.4	-0.7	0.7	-0.7	0.6	0.3
Heart weight	0.1	0.1	0.3	0.6	0.1	-0.1	0.1	-0.1	-0.3
Delay discount hyperbolic model param	1.9	2.0	5.3	-2.3	2.0	-0.9	0.9	-0.9	-0.5
Intermittent access intake day 1-15 change	0.4	0.4	0.6	-0.6	-0.4	0.7	-0.7	0.7	0.8
Intermittent access intake escalation	0.4	0.4	0.9	-0.9	-0.0	0.6	-0.6	0.6	0.8
Intermittent access intake escalation 2	0.4	0.4	0.7	-0.8	-0.5	0.7	-0.7	0.7	0.5
Intermitt. access day 1 inactive lever presses	1.6	1.8	2.5	-0.5	1.2	-1.6	1.6	-1.4	-1.3
Intermitt. access day 15 inactive lever presses	1.8	1.9	2.8	-1.7	1.5	-1.3	1.3	-1.2	-1.3
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	0.2	0.2	-0.2	0.3	0.1
Intermittent access day 1 total infusions	0.4	0.4	1.0	-1.0	0.9	-0.4	0.5	-0.5	0.0
Intermittent access day 15 total infusions	0.4	0.4	1.8	-1.3	0.7	0.1	-0.1	0.0	0.5
Intermittent access terminal intake (last 3 days)	0.9	1.0	4.0	-2.0	1.1	-0.5	0.5	-0.5	-0.1
Intermittent access total infusions	0.8	0.9	3.1	-1.8	1.2	-0.5	0.5	-0.5	-0.1
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.2	0.2	0.3	-0.3	0.2	0.6
Intermittent access day 15 total locomotion	0.3	0.3	0.8	-0.9	0.9	-0.1	0.1	-0.1	0.5
Intermittent access total locomotion	0.5	0.6	1.4	-1.2	1.1	-0.5	0.6	-0.7	-0.2
Intermittent access standard deviation	0.6	0.7	1.7	-1.3	0.7	-0.7	0.7	-0.8	-0.5
Left kidney weight	13.0	36.6	43.0	-6.0	6.6	-6.1	6.1	-6.2	-5.2
Right kidney weight	13.6	38.2	42.2	-6.2	6.5	-6.3	6.3	-6.2	-5.5
Cocaine induced anxiety	4.5	5.2	6.6	-1.4	2.1	-2.5	2.5	-2.5	-2.6
Post-drug Anxiety	3.5	3.8	6.7	-1.0	1.8	-2.1	2.1	-1.9	-2.6
Baseline Anxiety	2.4	2.5	3.5	0.8	-1.5	1.8	-1.8	1.9	1.5
Tail length	0.3	0.8	1.5	0.8	-1.1	0.8	-0.8	0.7	1.2
Length with tail	0.1	0.2	0.9	-0.9	0.2	0.2	-0.2	0.1	0.7
Length without tail	0.4	0.8	3.2	-1.8	0.9	-0.4	0.4	-0.5	-0.1
Times rat made contact with spout	0.3	0.3	0.7	-0.5	0.3	-0.6	0.6	-0.8	-0.4
Lifetime Intake	0.9	1.1	3.2	-1.8	1.3	-0.7	0.7	-0.7	-0.2
Liver weight, left	0.6	1.0	1.5	-0.5	0.6	-1.2	1.2	-1.2	-0.9
Liver weight, right	0.2	0.3	0.8	-0.9	0.1	-0.3	0.3	-0.6	0.5
Locomotor activity	1.7	2.7	6.0	-2.4	1.6	-1.4	1.4	-1.4	-1.3
Locomotor testing distance	0.1	0.2	1.2	-1.1	0.3	-0.1	0.1	-0.2	-0.2
Locomotor testing rearing	0.3	0.5	1.6	-1.3	0.7	-0.4	0.4	-0.6	-0.3
Locomotion in novel chamber	1.3	1.6	3.0	0.8	-0.8	1.3	-1.3	1.4	1.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.0	0.3	-0.2	0.2	-0.0	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.4	0.5	0.0	0.5	-0.6	0.6	-0.7	-0.7
Change in fecal boli incidents, locomotor task	0.8	0.7	1.3	0.4	-0.4	0.9	-0.9	1.0	1.1
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.5	-0.5	0.9	-0.9	0.9	-1.0	-1.2
Bouts of movement, locomotor time 1	0.7	0.7	1.4	-0.6	0.4	-0.8	0.9	-1.0	-1.2
Total resting periods, locomotor time 1	0.5	0.6	1.3	-0.5	0.3	-0.7	0.7	-0.9	-1.2
Rest time, locomotor task time 1	1.1	1.2	1.9	-0.9	0.7	-1.1	1.1	-1.2	-1.4
Distance moved, locomotor task time 1	0.0	0.0	0.2	0.0	0.4	-0.2	0.2	-0.1	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.0	0.0	0.4	-0.4	0.5	0.1
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.6	-1.2	0.6	0.4	-0.4	0.3	0.0
Bouts of movement, locomotor time 2	0.4	0.4	0.8	0.8	-0.5	-0.5	0.5	-0.6	-0.9
Total resting periods, locomotor time 2	0.5	0.5	0.9	1.0	-0.6	-0.5	0.6	-0.7	-0.9
Rest time, locomotor task time 2	1.7	2.0	4.3	2.0	-2.1	1.0	-1.0	0.9	0.9
Distance moved, locomotor task time 2	2.0	2.3	4.9	-2.1	2.2	-1.1	1.1	-1.0	-0.9
Vertical activity count, locomotor time 2	2.3	2.5	6.2	-2.5	2.3	-0.9	0.9	-0.8	-1.0
Light reinforcement 1	0.2	0.3	0.9	-1.0	0.9	0.1	-0.1	0.1	0.3
Light reinforcement 2	1.5	2.1	5.1	-2.3	1.8	-1.0	1.0	-1.0	-1.0
Bone: marrow area	1.9	4.1	6.1	-1.9	2.5	-2.1	2.1	-1.8	-1.8
Bone: maximum diameter	4.6	8.5	13.1	-3.6	3.4	-2.7	2.6	-2.4	-2.5
Bone: maximum force	2.2	3.8	5.0	-1.4	2.0	-2.0	2.0	-1.9	-2.2
Bone: maximum moment	2.7	4.7	6.2	-1.7	2.2	-2.2	2.2	-2.1	-2.5
Mean time between licks in bursts	1.7	2.3	2.9	1.1	-1.4	1.7	-1.7	1.7	1.5
Mean num. licks in bursts	2.0	2.4	3.7	-1.3	1.4	-1.7	1.7	-1.9	-1.2
Cd content in liver	0.3	0.3	0.4	0.4	-0.5	0.6	-0.6	0.5	0.5
Co content in liver	0.3	0.3	1.2	-1.1	0.7	-0.3	0.3	-0.3	-0.1
Cu content in liver	6.1	7.4	10.2	3.2	-2.5	2.8	-2.8	2.9	2.0
Fe content in liver	0.1	0.1	0.7	-0.8	0.1	0.1	-0.1	0.0	-0.2
K content in liver	0.1	0.1	0.2	0.5	0.4	-0.1	0.1	-0.0	0.0
Mg content in liver	0.1	0.1	0.3	0.6	-0.0	0.1	-0.1	0.3	-0.2
Mn content in liver	0.4	0.4	1.1	-1.1	0.7	-0.5	0.5	-0.6	0.1
Na content in liver	1.8	1.9	3.0	1.7	-1.4	1.3	-1.3	1.5	1.0
Rb content in liver	0.2	0.3	0.5	0.6	-0.4	0.6	-0.6	0.7	0.1
Se content in liver	0.6	0.8	1.4	0.5	-0.5	1.0	-1.0	0.9	1.2
Sr content in liver	0.8	0.7	1.5	1.2	-1.0	0.6	-0.6	0.5	0.9
Zn content in liver	1.3	1.4	1.6	1.2	-1.0	1.2	-1.2	1.3	1.2
Bone: minimum diameter	0.6	1.2	3.2	-1.8	1.5	-0.8	0.7	-0.5	-0.6
Time in familiar zone, hab. session 1	0.6	0.6	1.1	-0.8	1.0	-0.7	0.7	-0.6	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.2	0.4	-0.4	0.4	0.3
Total zone transitions, hab. session 1	1.6	2.2	3.4	1.8	-1.4	1.4	-1.4	1.4	1.5
Total locomotion distance, hab. session 1	0.1	0.1	0.7	0.3	0.0	0.2	-0.2	0.2	0.8
Locomotion velocity, hab. session 1	0.1	0.1	0.4	0.1	-0.0	0.1	-0.1	0.0	0.7
Time in familiar zone, hab. session 2	0.5	0.5	1.1	-0.5	-0.4	0.8	-0.8	0.8	1.0
Time in novel zone, hab. session 2	0.1	0.1	0.4	0.7	-0.1	-0.0	0.0	-0.0	-0.1
Total zone transitions, hab. session 2	0.2	0.3	0.6	-0.2	0.8	-0.6	0.6	-0.4	-0.5
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.5	0.6	-0.3	0.3	-0.2	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.5	0.5	-0.3	0.3	-0.2	-0.2
Novel to familiar place preference ratio	0.0	0.0	0.1	0.2	-0.1	0.2	-0.1	0.0	0.3
Novelty place preference	0.0	0.0	0.1	-0.0	0.2	0.0	-0.0	-0.2	0.3
Time in novel zone, NPP test	0.0	0.0	0.1	-0.1	0.2	0.0	-0.0	-0.1	0.3
Total zone transitions, NPP test	0.7	1.0	2.1	1.4	-0.8	0.8	-0.8	0.7	1.1
Total locomotion distance, NPP test	0.1	0.1	0.3	0.5	-0.0	0.2	-0.2	0.2	0.5
Locomotion velocity, NPP test	0.2	0.2	0.5	0.7	-0.3	0.4	-0.4	0.4	0.6
Intraocular pressure	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.1	0.1	0.3
Delta distance traveled before/after self-admin	0.3	0.3	1.1	-1.0	0.9	-0.2	0.2	-0.2	-0.3
Delta ambulatory time before/after self-admin	0.2	0.3	0.9	-1.0	0.7	0.1	-0.1	0.1	-0.1
Parametrial fat weight	0.2	0.5	1.3	1.0	-1.1	0.3	-0.3	0.2	0.6
Pavlov. Cond. lever latency	0.5	0.7	0.9	1.0	0.4	-0.9	0.9	-0.8	-0.9
Pavlov. Cond. magazine entry latency	0.9	1.1	1.6	-0.3	-1.1	1.3	-1.3	1.3	0.9
Pavlov. Cond. change in total contacts	0.6	0.6	1.0	-0.8	-0.7	0.9	-0.9	1.0	0.2
Pavlov. Cond. index score	0.6	0.7	0.9	-0.8	-0.7	0.9	-0.9	1.0	0.7
Pavlov. Cond. latency score	0.5	0.6	0.9	-1.0	-0.4	0.8	-0.8	0.8	0.6
Pavlov. Cond. lever contacts	0.7	0.8	1.6	-1.2	-0.4	0.9	-0.9	0.9	1.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.3	0.5	1.0	-1.1	1.1	-1.1	-0.8
Pavlov. Cond. intertrial magazine entries	1.2	1.5	1.7	1.2	-1.2	1.3	-1.3	1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.4	-0.5	-0.9	1.2	-1.2	1.2	0.9
Pavlov. Cond. response bias	1.1	1.3	1.7	-0.9	-1.0	1.3	-1.3	1.3	1.0
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.5	-0.6	0.6	-0.6	0.5	0.7
Pavlov. Cond. magazine entry latency	0.3	0.3	1.3	1.1	-0.4	0.3	-0.3	0.4	-0.5
Pavlov. Cond. change in total contacts	0.8	1.1	2.8	-0.4	0.8	-1.0	1.0	-0.8	-1.7
Pavlov. Cond. index score	0.1	0.1	0.5	0.2	0.2	-0.3	0.3	-0.2	-0.7
Pavlov. Cond. latency score	0.2	0.3	0.9	0.2	0.4	-0.4	0.4	-0.3	-0.9
Pavlov. Cond. lever contacts	0.6	0.8	1.1	-0.6	1.0	-0.9	0.9	-0.8	-1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.6	-0.2	0.3	-0.3	0.2	0.8
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.4	-0.9	0.9	-1.2	1.2	-1.2	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.4	0.2	-0.3	0.3	-0.2	-0.7
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.2	0.5	-0.6	0.6	-0.5	-1.0
Time in closed arm before self-admin	0.8	0.9	1.3	0.7	-0.9	1.1	-1.1	1.1	0.7
Time in closed arm after self-admin	0.1	0.1	0.2	-0.1	-0.2	0.3	-0.4	0.4	0.2
Time in open arm before self-admin	0.1	0.1	0.6	0.7	-0.1	-0.2	0.2	-0.3	-0.1
Time in open arm after self-admin	0.3	0.3	0.4	0.6	0.4	-0.7	0.7	-0.6	-0.3
Bone: periosteal estimation	2.1	4.3	6.3	-2.4	2.5	-2.0	1.9	-1.7	-1.8
Bone: periosteal perimeter	2.1	3.6	9.1	-3.0	2.3	-1.4	1.3	-1.2	-1.3
Bone: post-yield work	0.2	0.2	0.5	0.7	-0.2	-0.2	0.3	-0.4	-0.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.3	-0.1	0.2	-0.2	0.0	0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.2	-0.2	0.3	-0.3	0.1	0.5
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.2	0.4	-0.4	0.4	-0.5	-0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	-0.3	0.4	-0.5	0.6	-0.7	-0.1
Progressive ratio test 2 breakpoint	0.3	0.3	0.7	-0.4	0.4	-0.6	0.7	-0.8	-0.3
Progressive ratio test 2 inactive lever presses	0.6	0.7	0.9	-0.9	1.0	-0.8	0.8	-0.9	-0.3
Incentive Sensitization - Responses	1.0	1.0	1.6	-0.6	0.9	-1.1	1.2	-1.3	-0.9
Incentive Sensitization - Breakpoint	1.3	1.3	2.1	-0.7	1.0	-1.3	1.3	-1.4	-1.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	-0.1	0.6	-0.6	0.6	-0.7	-0.9
Progressive ratio	0.2	0.3	0.7	0.9	-0.9	0.1	-0.1	-0.0	0.1
Food seeking constrained by brief footshock	0.6	0.8	1.0	-0.9	1.0	-0.9	0.8	-0.9	-0.7
Seeking ratio, punishment vs. effort	0.8	1.0	2.2	-1.3	1.5	-0.8	0.8	-0.6	-0.8
Retroperitoneal fat weight	1.5	4.8	6.4	-2.5	2.2	-2.2	2.2	-2.3	-1.6
Reaction time number correct	0.2	0.3	0.4	0.6	-0.6	0.6	-0.6	0.5	0.5
Reaction time mean minus median	0.1	0.1	0.4	0.6	-0.5	0.2	-0.2	0.2	0.3
Reaction time mean minus median AUC	0.2	0.3	0.7	0.8	0.0	-0.6	0.6	-0.6	-0.3
Reaction time num false alarms	0.6	0.8	1.2	0.1	-0.6	1.0	-1.0	0.9	1.1
Reaction time num false alarms AUC	0.6	0.8	1.8	0.1	-0.6	1.0	-1.0	0.9	1.3
Reaction time trials correct on left	0.2	0.3	0.4	0.6	-0.6	0.6	-0.6	0.5	0.5
Reaction time trials on left	0.2	0.3	0.4	0.6	-0.6	0.6	-0.6	0.5	0.5
Reaction time mean	0.6	0.9	2.7	1.7	-1.0	0.6	-0.6	0.7	0.5
Reaction time mean AUC	0.8	1.1	3.8	2.0	-1.1	0.6	-0.6	0.7	0.6
Median of all reaction times	0.9	1.2	3.3	1.8	-1.2	0.8	-0.8	0.9	0.6
Reaction time omissions	0.7	1.0	1.3	1.2	-1.1	1.0	-1.0	1.0	0.7
Reaction time false alarm rate	0.2	0.2	0.6	-0.3	-0.3	0.5	-0.5	0.4	0.8
Reaction time premature initiation rate	2.0	2.6	4.5	-0.8	1.3	-1.7	1.7	-1.7	-2.1
Reaction time premature initiations	1.0	1.3	2.7	-0.4	0.8	-1.2	1.2	-1.2	-1.7
Std. dev. reaction times	0.3	0.4	1.2	1.1	-0.8	0.4	-0.4	0.4	0.6
Reaction time trials completed	0.2	0.3	0.4	0.6	-0.6	0.6	-0.6	0.5	0.5
Reaction time trials AUC	0.1	0.1	0.1	0.4	-0.3	0.3	-0.3	0.3	0.2
Run reversals in cocaine runway, females	2.0	1.9	2.6	0.4	-1.0	1.6	-1.6	1.6	1.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	0.3	-0.4	0.4	-0.2	0.3
Latency to leave start box in cocaine runway	1.2	1.3	2.0	-1.3	1.4	-1.1	1.1	-1.1	-0.9
Latency to leave start box in cocaine runway, F	0.5	0.6	0.9	-1.0	0.8	-0.7	0.7	-0.7	-0.5
Latency to leave start box in cocaine runway, M	1.2	1.1	1.9	-1.1	1.4	-0.9	0.9	-1.1	-0.9
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	0.1	0.0	-0.0	0.2	-0.4
Total sessions with >9 infusions	0.7	0.8	3.6	-1.9	1.0	-0.3	0.3	-0.2	0.2
Short access day 1 total inactive lever presses	1.7	1.9	3.6	-1.9	1.8	-1.1	1.1	-0.9	-0.8
Short access day 10 total inactive lever presses	1.5	1.7	2.2	-1.0	1.2	-1.5	1.5	-1.2	-1.3
Short access day 1 total infusions	0.7	0.7	1.6	-1.3	1.1	-0.7	0.7	-0.7	-0.2
Short access day 10 total infusions	0.6	0.6	2.7	-1.7	0.9	-0.3	0.3	-0.3	-0.1
Short access total infusions	1.9	2.2	5.1	-2.2	1.8	-1.2	1.2	-1.1	-0.8
Short access day 1 locomotion	0.0	0.1	0.2	-0.4	0.2	0.1	-0.1	0.0	0.2
Short access day 10 total locomotion	0.4	0.4	0.9	-0.1	-0.4	0.7	-0.7	0.6	1.0
Short access total locomotion	0.4	0.4	1.9	-1.4	0.8	-0.2	0.2	-0.2	-0.1
One hour access (0.3 mA shock)	0.3	0.3	0.9	-1.0	0.7	-0.3	0.3	-0.4	0.3
Compulsive drug intake	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	-0.1	-0.3
One hour access (shock baseline)	0.3	0.3	1.3	-1.2	0.5	0.1	-0.1	0.1	0.7
Social response proportion	0.8	0.9	2.8	-1.7	1.1	-0.5	0.6	-0.7	-0.5
Social responses	0.6	0.8	3.0	-1.7	1.0	-0.4	0.4	-0.6	-0.1
Social time	1.3	1.7	2.4	0.4	-1.6	1.4	-1.4	1.1	1.5
Soleus weight	0.3	0.8	1.0	-1.0	0.6	-0.9	0.9	-0.9	-0.9
Bone: stiffness	0.7	1.1	3.1	0.2	0.8	-1.1	1.1	-0.9	-1.8
Tibialis anterior weight	0.0	0.1	0.3	0.6	0.0	-0.0	0.0	0.2	-0.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	0.9	-0.3	0.2	-0.2	0.1	0.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2	0.3	0.2
Time to tail flick, test, before self-admin	0.3	0.3	1.6	-1.3	0.6	-0.1	0.1	-0.2	0.1
Time to tail flick, test, after self-admin	0.9	0.9	1.8	-0.3	-0.6	1.1	-1.2	1.3	0.7
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.6	-0.9	0.7	-1.0	1.0	-0.9	-1.3
Delta time to tail flick, test, before/after SA	1.6	1.5	2.2	1.2	-1.1	1.3	-1.3	1.5	0.8
Tibia length	0.0	0.1	0.6	-0.8	0.3	-0.1	0.1	-0.1	-0.1
Ambulatory time before self-admin	0.1	0.1	0.2	0.0	0.1	-0.5	0.5	-0.4	-0.0
Ambulatory time after self-admin	0.2	0.2	0.6	-0.8	0.4	0.2	-0.3	0.3	0.1
Bone: tissue strength	0.2	0.2	0.6	0.7	-0.0	-0.1	0.1	-0.1	-0.8
Total heroin consumption	0.9	1.1	1.5	-0.3	1.2	-1.1	1.1	-1.2	-1.2
Bone: trabecular number	1.5	2.4	2.8	1.3	-1.5	1.6	-1.6	1.7	1.5
Bone: trabecular spacing	4.6	6.0	6.7	-2.1	2.4	-2.6	2.6	-2.4	-2.5
Bone: trabecular thickness	0.3	0.3	0.5	0.5	-0.6	0.6	-0.6	0.5	0.7
Bone: trabecular tissue density	0.2	0.3	1.4	1.2	-0.6	0.0	-0.0	0.0	-0.3
Water consumed over 24 hours	2.0	2.4	3.9	-2.0	1.8	-1.4	1.4	-1.4	-1.2
Number of responses in last shaping day	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2	0.2	0.1