Hub : Genes

Wnt5a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Wnt5a	0.04	0.02	1.3e-03	0.02	0.02	0.01	0.02	2.2e-03	2.7e-03	1.3e-02	6.1e-03
2	Liver	gene expression	Wnt5a	0.06	0.04	2.6e-05	0.03	0.03	0.03	0.04	2.3e-04	1.3e-04	2.3e-04	6.7e-05
3	Brain	gene expression	Wnt5a	0.12	0.07	6.6e-04	0.03	0.03	0.05	0.05	3.8e-04	3.9e-04	1.7e-05	2.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.5	0.8	2.1	-1.5	0.1	-0.5
Area under the delay curve	0.0	0.0	0.0	0.0	-0.1	-0.1
BMI with tail	0.9	2.9	5.7	-2.4	1.4	-1.0
BMI without tail	1.6	3.4	5.5	-2.4	2.1	-0.2
Body weight	1.4	5.8	8.5	-2.9	2.8	-0.8
Weight adjusted by age	1.2	1.3	2.9	1.0	0.2	1.7
Bone surface	0.6	1.0	2.6	-1.6	0.2	-0.6
Bone volume	1.1	1.8	3.8	-1.9	0.4	-1.3
Breakpoint value in progressive ratio session	0.4	0.4	0.6	0.8	-0.7	-0.3
Number of licking bursts	0.1	0.1	0.2	-0.4	0.3	0.0
Context. condit. distance diff. score	0.1	0.1	0.3	0.2	-0.2	0.5
Locomotion velocity, session 1	4.1	4.4	9.1	3.0	-1.8	1.0
Locomotion distance, session 1	2.4	3.0	7.0	2.6	-1.4	0.5
Locomotion velocity, session 2	3.3	3.8	8.6	2.9	-0.8	1.5
Locomotion distance, session 2	0.9	1.3	3.4	1.8	-0.4	0.7
Locomotion velocity, session 3	1.7	2.0	4.0	2.0	-1.4	-0.1
Locomotion distance, session 3	1.2	1.4	3.0	-0.1	-1.0	-1.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	-0.4	0.5
Stereotopy head waving duration, day 3	0.4	0.4	0.8	0.5	-0.6	0.9
Locomotion velocity, session 7	0.2	0.2	0.6	0.8	0.1	-0.3
Locomotion distance, session 7	0.7	0.8	2.4	0.1	-0.2	-1.6
Stereotopy head waving bouts, day 7	1.9	2.1	2.8	-1.3	1.7	1.3
Stereotopy head waving duration, day 7	1.7	2.1	2.4	-1.2	1.5	1.6
Locomotion velocity, session 8	6.3	7.5	15.6	4.0	-2.4	1.2
Locomotion distance, session 8	1.3	1.9	4.6	2.1	-0.8	0.5
Degree of sensitization distance	0.2	0.2	0.4	0.3	0.6	0.3
Degree of sensitization stereotypy	2.1	2.4	3.5	-1.2	1.9	1.4
Conditioned locomotion	0.5	0.6	1.1	-1.1	0.8	0.3
Cocaine response after cond. corrected	0.2	0.3	0.6	0.8	-0.4	0.2
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.6	-0.3	-0.0
Cocaine response before conditioning	0.4	0.4	0.9	-0.0	-0.6	-1.0
Saline control response	1.5	2.0	3.3	-1.8	0.8	-1.5
Bone: connectivity density	0.7	1.1	1.6	-1.3	0.7	1.1
Bone: cortical apparent density	2.1	2.8	5.9	1.5	-2.4	-0.1
Bone: cortical area	6.0	9.1	19.6	-4.4	2.0	-1.9
Bone: cortical porosity	1.0	1.1	3.0	-0.5	1.7	0.1
Bone: cortical porosity	0.7	0.8	2.0	-0.6	1.4	-0.4
Bone: cortical thickness	2.5	4.2	8.9	-3.0	1.5	-1.1
Bone: cortical thickness	2.3	2.6	5.1	-2.3	1.7	0.0
Bone: cortical tissue density	2.7	3.6	7.3	1.9	-2.7	-0.0
Condit. Reinf. active minus inactive responses	1.4	1.5	3.1	-0.5	-1.1	-1.8
Condit. Reinf. active-inactive response ratio	2.4	2.5	3.6	-1.6	-1.1	-1.9
Condit. Reinf. active responses	0.2	0.3	0.4	0.3	-0.6	-0.6
Condit. Reinf. inactive responses	1.5	1.8	3.1	1.8	0.5	1.5
Incentive salience index mean	0.4	0.5	0.9	-0.6	-0.3	-0.9
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.5	0.5	0.1
Condit. Reinf. active minus inactive responses	0.8	0.9	1.4	-0.5	1.0	1.2
Condit. Reinf. active-inactive response ratio	2.3	2.4	3.7	-1.7	1.9	0.8
Condit. Reinf. active responses	0.2	0.3	0.5	-0.3	0.4	0.7
Condit. Reinf. inactive responses	1.0	1.2	2.2	1.5	-1.2	-0.1
Condit. Reinf. lever presses	0.6	0.8	1.3	-1.0	-0.3	-1.1
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	-0.4	0.4	0.5
Conditioned reinforcement - actives	0.7	0.8	1.7	-0.4	1.3	0.6
Conditioned reinforcement - inactives	2.5	2.8	4.3	-2.0	0.4	-2.1
Conditioned locomotion	0.4	0.5	0.5	-0.6	0.7	-0.7
Patch foraging indifference point 0 sec	1.4	2.3	4.0	0.3	-1.7	-2.0
Patch foraging indifference point AUC	0.4	0.5	0.9	-0.1	1.0	0.8
Delay disc. indifference point, 0s delay	0.9	1.0	1.9	-0.9	1.4	0.3
Delay disc. indifference point, 16s delay	0.3	0.3	0.5	0.7	-0.7	-0.1
Delay disc. indifference point, 2s delay	0.2	0.3	0.4	0.6	-0.6	0.2
Delay disc. indifference point, 24s delay	1.6	1.5	2.1	1.5	-1.3	0.9
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	-0.8	0.1	-0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.2	0.4	-0.1
Indifference point function ln k	1.2	1.7	3.9	-0.7	-0.9	-2.0
Indifference point function log k	1.2	1.7	3.9	-0.7	-0.9	-2.0
Patch foraging total patch changes 0 sec	1.8	2.9	5.7	0.1	-1.7	-2.4
Patch foraging total patch changes 12 sec	1.2	1.5	2.2	1.0	-1.2	-1.5
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	0.3	-0.8	-0.4
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.0	-0.3	-0.4
Patch foraging total patch changes 6 sec	0.5	0.7	1.1	0.0	-1.1	-1.0
Patch foraging time to switch 0 sec	1.3	2.0	2.9	1.7	-0.8	1.5
Patch foraging water rate 0 sec	1.9	3.1	4.8	-2.2	-0.0	-2.1
Patch foraging water rate 12 sec	0.4	0.6	0.7	-0.8	-0.8	-0.8
Patch foraging water rate 18 sec	0.7	1.0	1.9	-1.4	0.0	-1.1
Patch foraging water rate 24 sec	2.0	2.7	6.1	-2.5	0.4	-1.4
Patch foraging water rate 6 sec	1.0	1.5	2.5	-1.6	-0.2	-1.4
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.3	-1.2	1.0	-1.5
Distance traveled before self-admin	1.3	1.4	2.3	0.0	-1.5	-1.4
Distance traveled after self-admin	1.3	1.4	3.3	-0.4	-0.9	-1.8
Extensor digitorum longus weight	1.8	7.1	12.1	0.7	-3.5	-2.9
Bone: elastic displacement	0.9	1.0	1.7	1.3	-1.1	0.0
Bone: elastic work	1.3	1.6	2.7	-1.6	1.3	-0.7
Bone: endosteal estimation	4.9	10.6	20.0	-4.5	3.1	-1.4
Bone: endosteal perimeter	2.3	4.8	10.3	-3.2	1.8	-1.0
Epididymis fat weight	1.7	4.0	7.4	-1.0	2.7	1.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	-0.4	0.5	0.4
Delta time in open arm before/after self-admin	1.2	1.2	2.4	-0.3	-1.0	-1.6
Diff in mean of infusions in LGA sessions	4.4	4.9	7.3	2.7	0.3	2.7
Delay discount exponential model param	0.0	0.0	0.0	-0.0	0.1	-0.0
Extinction: sum of active levers before priming	1.7	1.7	2.3	0.8	-1.5	-1.5
Active lever presses in extinction session 6	0.1	0.1	0.4	0.6	0.0	-0.3
Bone: final force	6.3	10.2	19.5	-4.4	3.2	-0.9
Bone: final moment	6.4	10.4	18.8	-4.3	3.4	-1.0
Food consumed during 24 hour testing period	3.5	4.2	6.2	1.0	-2.3	-2.5
Glucose	0.1	0.2	0.7	0.0	0.8	0.1
Heart weight	0.1	0.1	0.3	0.1	-0.5	-0.1
Delay discount hyperbolic model param	0.0	0.0	0.0	0.0	0.1	-0.0
Intermittent access intake day 1-15 change	0.4	0.4	0.6	0.4	0.8	0.7
Intermittent access intake escalation	0.7	0.7	1.0	0.6	0.8	1.0
Intermittent access intake escalation 2	0.2	0.2	0.3	0.1	0.5	0.5
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.5	-0.1	-0.7	-0.7
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.7	0.9	-0.5	0.5
Intermitt. access escalation Index	0.8	0.7	1.7	-1.3	0.5	-0.4
Intermittent access day 1 total infusions	1.6	1.8	5.1	-0.3	-0.5	-2.3
Intermittent access day 15 total infusions	0.6	0.6	1.5	0.6	-0.2	-1.2
Intermittent access terminal intake (last 3 days)	0.8	0.8	2.0	-0.0	0.7	-1.4
Intermittent access total infusions	0.7	0.8	2.0	-0.2	0.5	-1.4
Intermittent access day 1 locomotion	1.7	1.8	4.7	0.1	-0.8	-2.2
Intermittent access day 15 total locomotion	0.7	0.7	1.9	-0.4	0.1	-1.4
Intermittent access total locomotion	0.6	0.6	1.9	-0.1	0.2	-1.4
Intermittent access standard deviation	1.1	1.1	2.2	-1.1	1.5	-0.0
Left kidney weight	1.1	3.0	5.3	-1.0	2.3	1.7
Right kidney weight	1.0	2.7	4.2	-1.9	2.0	-0.5
Cocaine induced anxiety	0.8	0.9	2.3	-0.6	1.5	0.2
Post-drug Anxiety	0.1	0.1	0.2	0.1	0.1	-0.5
Baseline Anxiety	0.9	0.9	1.9	0.7	-1.4	-0.6
Tail length	0.4	1.2	2.6	-1.0	1.6	0.0
Length with tail	0.3	1.0	2.6	-0.7	1.6	-0.1
Length without tail	0.3	0.6	0.9	-0.5	1.0	-0.7
Times rat made contact with spout	3.2	3.7	6.5	0.3	-2.2	-2.6
Lifetime Intake	0.7	0.7	1.9	-0.1	0.5	-1.4
Liver weight, left	0.3	0.5	0.8	-0.9	0.9	0.0
Liver weight, right	0.4	0.6	1.9	-0.2	0.2	-1.4
Locomotor activity	0.6	1.0	2.0	-1.4	0.8	-0.6
Locomotor testing distance	1.0	1.6	3.2	-1.8	1.2	-0.5
Locomotor testing rearing	0.8	1.2	2.4	-1.6	1.1	-0.2
Locomotion in novel chamber	0.3	0.3	0.4	0.4	-0.6	-0.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	-0.1	-0.3	0.5
Fecal boli incidents, locomotor time 1	0.6	0.6	1.5	-0.6	-0.1	-1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.2	0.5	0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.0	0.0	-0.6	-1.0
Bouts of movement, locomotor time 1	1.5	1.7	3.0	-1.1	1.7	-0.9
Total resting periods, locomotor time 1	0.6	0.7	1.7	-0.6	1.3	-0.3
Rest time, locomotor task time 1	1.3	1.5	2.6	-1.3	1.6	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.2	0.4	0.1
Vertical activity count, locomotor time 1	0.3	0.3	0.8	-0.4	0.1	-0.9
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.5	0.1	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.2	0.2	-0.5
Total resting periods, locomotor time 2	0.2	0.2	0.3	-0.3	0.6	-0.5
Rest time, locomotor task time 2	1.9	2.2	3.1	-1.8	1.6	1.0
Distance moved, locomotor task time 2	0.2	0.3	0.7	-0.2	0.9	0.1
Vertical activity count, locomotor time 2	0.7	0.8	1.8	-0.7	0.3	-1.3
Light reinforcement 1	0.2	0.4	1.1	1.1	0.2	0.4
Light reinforcement 2	0.6	0.8	1.5	0.8	0.6	1.2
Bone: marrow area	4.6	10.0	19.1	-4.4	3.0	-1.3
Bone: maximum diameter	1.8	3.4	7.7	-2.8	0.1	-1.5
Bone: maximum force	8.9	15.4	27.9	-5.3	4.2	-0.7
Bone: maximum moment	8.7	14.9	25.9	-5.1	4.3	-0.8
Mean time between licks in bursts	0.6	0.9	1.4	1.0	0.5	1.2
Mean num. licks in bursts	1.2	1.5	2.4	0.4	-1.6	-1.4
Cd content in liver	0.2	0.2	0.7	0.2	-0.8	-0.1
Co content in liver	0.7	0.8	1.8	0.4	-0.7	-1.4
Cu content in liver	1.2	1.4	2.2	0.9	-1.1	-1.5
Fe content in liver	0.1	0.1	0.2	0.4	-0.3	0.1
K content in liver	0.5	0.5	1.0	1.0	0.1	0.7
Mg content in liver	0.3	0.3	0.7	0.8	-0.3	0.4
Mn content in liver	1.3	1.5	2.4	1.3	-0.6	1.6
Na content in liver	0.9	0.9	1.2	1.0	0.8	1.1
Rb content in liver	1.1	1.4	2.1	-0.6	-1.4	-1.3
Se content in liver	1.1	1.3	3.4	0.8	0.2	1.8
Sr content in liver	0.4	0.3	0.7	-0.8	0.6	0.0
Zn content in liver	2.6	2.8	4.4	1.2	-1.6	-2.1
Bone: minimum diameter	7.6	14.3	26.3	-5.1	3.3	-2.4
Time in familiar zone, hab. session 1	2.4	2.2	4.4	-2.1	0.2	-1.5
Time in novel zone, hab. session 1	1.0	1.0	1.4	1.1	0.6	1.2
Total zone transitions, hab. session 1	1.3	1.8	3.2	1.8	-1.4	-0.4
Total locomotion distance, hab. session 1	0.8	1.2	2.9	1.7	-0.3	0.7
Locomotion velocity, hab. session 1	1.4	1.9	4.5	2.1	-1.0	0.6
Time in familiar zone, hab. session 2	4.4	4.6	8.0	0.3	-2.4	-2.8
Time in novel zone, hab. session 2	2.4	2.4	3.8	-0.5	1.8	1.9
Total zone transitions, hab. session 2	0.4	0.6	1.2	1.1	-0.7	-0.1
Total locomotion distance, hab. session 2	0.7	1.0	2.1	1.4	-0.9	-0.0
Locomotion velocity, hab. session 2	0.8	1.0	2.2	1.5	-0.9	0.3
Novel to familiar place preference ratio	0.5	0.5	1.0	-0.7	1.0	-0.3
Novelty place preference	0.3	0.3	0.4	-0.4	0.4	-0.6
Time in novel zone, NPP test	0.2	0.3	0.3	-0.5	0.5	-0.5
Total zone transitions, NPP test	1.8	2.6	4.9	2.2	-1.7	-0.0
Total locomotion distance, NPP test	1.7	2.3	5.0	2.2	-1.4	0.4
Locomotion velocity, NPP test	2.0	2.8	6.1	2.5	-1.4	0.6
Intraocular pressure	2.2	3.1	5.2	-0.3	-2.3	-2.0
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	0.3	-0.0
Delta ambulatory time before/after self-admin	0.4	0.4	1.2	0.2	-0.2	-1.1
Parametrial fat weight	1.3	2.5	4.4	-2.1	1.7	0.2
Pavlov. Cond. lever latency	0.4	0.5	1.0	0.1	0.6	1.0
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.0	-0.8	-0.6
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.4	-0.6	-0.3
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	-0.5	-0.4
Pavlov. Cond. latency score	0.2	0.2	0.5	-0.1	-0.4	-0.7
Pavlov. Cond. lever contacts	0.4	0.4	0.6	0.6	-0.8	-0.5
Pavlov. Cond. magazine entry number	0.5	0.7	1.3	-0.6	1.1	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.1	1.0	0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.4	-0.3	-0.1
Pavlov. Cond. response bias	0.6	0.7	1.1	1.0	-1.1	-0.2
Pavlov. Cond. lever latency	0.6	0.8	1.6	-0.1	1.2	0.8
Pavlov. Cond. magazine entry latency	3.6	4.2	9.7	1.3	-3.1	-1.1
Pavlov. Cond. change in total contacts	1.4	1.9	3.4	0.1	-1.9	-1.5
Pavlov. Cond. index score	2.1	2.7	6.3	1.0	-2.5	-0.9
Pavlov. Cond. latency score	2.7	3.3	7.6	0.9	-2.8	-1.2
Pavlov. Cond. lever contacts	0.7	1.0	1.9	0.3	-1.4	-1.0
Pavlov. Cond. magazine entry number	3.7	4.5	10.0	-1.1	3.2	1.5
Pavlov. Cond. intertrial magazine entries	5.8	7.6	16.4	-2.4	4.1	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	6.8	1.1	-2.6	-0.9
Pavlov. Cond. response bias	1.6	2.2	4.4	0.7	-2.1	-1.3
Time in closed arm before self-admin	0.3	0.3	0.8	0.1	-0.0	0.9
Time in closed arm after self-admin	0.4	0.4	1.1	-0.4	0.3	1.0
Time in open arm before self-admin	0.4	0.4	1.1	0.2	1.0	0.4
Time in open arm after self-admin	0.5	0.6	1.6	-0.1	-0.0	-1.3
Bone: periosteal estimation	7.4	15.3	31.8	-5.6	3.2	-1.9
Bone: periosteal perimeter	3.5	5.8	12.9	-3.6	1.5	-1.4
Bone: post-yield work	3.1	4.3	7.8	-2.8	2.2	0.4
Progressive ratio test 1 active lever presses	1.0	1.0	1.6	-0.7	1.0	-1.3
Progressive ratio test 1 breakpoint	1.3	1.3	2.4	-0.8	1.0	-1.5
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.4	-0.2	0.1	-1.2
Progressive ratio test 2 active lever presses	1.8	1.9	5.5	0.2	-0.4	-2.3
Progressive ratio test 2 breakpoint	1.6	1.8	5.3	-0.1	-0.2	-2.3
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.8	-0.4	0.3	-1.3
Incentive Sensitization - Responses	2.8	2.8	7.4	-0.1	-1.0	-2.7
Incentive Sensitization - Breakpoint	2.6	2.6	7.0	-0.1	-0.9	-2.7
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.3	0.7	0.5
Progressive ratio	0.5	0.6	1.3	-0.4	1.1	0.5
Food seeking constrained by brief footshock	1.3	1.6	3.7	-0.6	0.9	1.9
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	0.2	-0.7	0.4
Retroperitoneal fat weight	1.9	6.1	9.0	-3.0	3.0	0.7
Reaction time number correct	0.1	0.2	0.3	-0.2	0.6	-0.4
Reaction time mean minus median	1.4	1.9	2.7	-0.8	1.6	1.5
Reaction time mean minus median AUC	2.3	3.0	4.7	-1.9	2.2	0.8
Reaction time num false alarms	0.2	0.3	0.7	0.8	-0.3	-0.2
Reaction time num false alarms AUC	0.2	0.3	0.6	0.8	-0.5	0.0
Reaction time trials correct on left	0.1	0.2	0.3	-0.2	0.6	-0.4
Reaction time trials on left	0.2	0.2	0.5	-0.2	0.7	-0.3
Reaction time mean	1.8	2.5	4.9	-1.2	2.2	1.0
Reaction time mean AUC	2.0	2.7	5.5	-1.1	2.3	1.2
Median of all reaction times	1.4	2.0	4.1	-1.1	2.0	0.8
Reaction time omissions	1.1	1.5	2.2	-0.7	1.5	1.4
Reaction time false alarm rate	0.2	0.3	0.4	0.7	-0.5	0.3
Reaction time premature initiation rate	0.6	0.8	1.0	-1.0	0.6	1.0
Reaction time premature initiations	0.9	1.3	1.5	-1.2	1.2	1.0
Std. dev. reaction times	2.1	3.0	4.6	-1.4	2.1	1.6
Reaction time trials completed	0.2	0.2	0.5	-0.2	0.7	-0.3
Reaction time trials AUC	0.3	0.5	0.5	-0.6	0.7	-0.7
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.4	-0.4	0.8
Run reversals in cocaine runway, males	2.1	2.1	3.2	1.8	-1.7	-0.5
Latency to leave start box in cocaine runway	0.5	0.5	0.9	0.1	1.0	0.8
Latency to leave start box in cocaine runway, F	0.2	0.2	0.2	0.5	0.4	0.4
Latency to leave start box in cocaine runway, M	0.4	0.4	0.7	-0.9	0.6	0.2
Std. dev. time between licks in bursts	1.7	2.0	4.0	0.6	1.3	2.0
Total sessions with >9 infusions	0.8	0.9	1.4	-0.6	1.2	-1.0
Short access day 1 total inactive lever presses	0.3	0.3	0.5	-0.3	-0.7	-0.6
Short access day 10 total inactive lever presses	1.6	1.7	2.7	1.6	-1.6	0.4
Short access day 1 total infusions	1.6	1.7	2.9	-1.4	0.4	-1.7
Short access day 10 total infusions	0.5	0.6	0.8	0.9	0.6	0.7
Short access total infusions	0.7	0.8	1.7	-0.4	0.7	-1.3
Short access day 1 locomotion	2.3	2.5	6.2	-0.7	-0.8	-2.5
Short access day 10 total locomotion	0.3	0.4	1.0	-0.3	1.0	0.1
Short access total locomotion	0.1	0.1	0.1	0.3	0.3	-0.3
One hour access (0.3 mA shock)	0.3	0.3	0.9	1.0	-0.1	-0.3
Compulsive drug intake	0.6	0.6	1.7	0.4	0.0	1.3
One hour access (shock baseline)	0.2	0.3	0.6	0.2	0.4	-0.8
Social response proportion	0.1	0.1	0.3	-0.0	-0.5	0.1
Social responses	0.5	0.7	1.1	0.8	-0.5	1.1
Social time	1.4	1.9	5.0	0.6	0.5	2.2
Soleus weight	1.1	3.4	7.3	-2.7	0.8	-1.5
Bone: stiffness	7.6	12.1	21.0	-4.6	3.9	-0.3
Tibialis anterior weight	0.9	3.2	5.7	-1.9	0.4	-2.4
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	0.4	0.4	0.6
Time to tail flick, vehicle, after self-admin	2.5	2.6	4.7	1.8	0.1	2.2
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.6	-0.2	-0.4
Time to tail flick, test, after self-admin	0.4	0.4	0.9	0.4	1.0	0.5
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	1.0	-0.2	1.0
Delta time to tail flick, test, before/after SA	0.3	0.2	0.3	-0.4	0.6	0.4
Tibia length	0.6	1.6	2.8	1.4	0.0	1.7
Ambulatory time before self-admin	0.4	0.4	0.9	-0.3	-1.0	-0.4
Ambulatory time after self-admin	2.5	2.7	5.4	0.1	-1.7	-2.3
Bone: tissue strength	0.9	0.9	1.3	-1.1	1.2	0.1
Total heroin consumption	0.1	0.1	0.2	0.4	0.3	-0.1
Bone: trabecular number	1.4	2.2	3.9	-2.0	1.6	0.4
Bone: trabecular spacing	0.2	0.3	0.6	0.4	0.8	-0.4
Bone: trabecular thickness	0.2	0.3	0.3	-0.6	-0.5	-0.4
Bone: trabecular tissue density	0.1	0.1	0.2	-0.4	0.3	0.3
Water consumed over 24 hours	1.2	1.5	3.5	0.2	-1.9	-1.0
Number of responses in last shaping day	1.1	1.1	3.1	-0.3	-0.3	-1.8