Wnt4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Wnt4 0.09 0.05 1.7e-08 0.06 0.06 0.06 0.06 2.0e-07 7.5e-07 4.8e-07 3.5e-07
2 Liver alternative polyA XM_039110876.1 0.02 0.02 5.7e-03 0.01 0.02 0.01 0.01 5.4e-02 5.5e-03 1.1e-02 2.4e-02
3 Liver alternative polyA NM_053402.2 0.02 0.02 7.2e-03 0 0.01 0.01 0.01 2.3e-01 1.0e-02 1.3e-02 6.2e-02
4 Liver alternative TSS NM_053402.2 0.02 0.01 4.3e-03 0 -0 -0 -0 2.6e-01 4.2e-01 5.3e-01 8.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.01.73.71.91.3-1.20.2
Area under the delay curve0.20.20.5-0.3-0.40.50.7
BMI with tail0.20.61.71.30.6-0.5-0.5
BMI without tail0.51.01.11.01.1-1.1-0.9
Body weight2.410.211.62.83.4-3.4-3.1
Weight adjusted by age0.50.51.2-1.0-0.20.1-1.1
Bone surface0.91.73.11.81.4-1.3-0.2
Bone volume1.01.73.21.81.3-1.30.1
Breakpoint value in progressive ratio session0.80.91.70.40.9-0.9-1.3
Number of licking bursts0.20.20.4-0.6-0.40.40.2
Context. condit. distance diff. score1.51.82.41.61.5-1.4-0.8
Locomotion velocity, session 10.70.81.51.20.3-0.21.2
Locomotion distance, session 10.70.92.41.1-0.10.21.6
Locomotion velocity, session 23.23.86.0-1.3-1.91.92.5
Locomotion distance, session 20.71.02.31.50.7-0.61.0
Locomotion velocity, session 30.91.12.7-0.2-0.80.91.6
Locomotion distance, session 32.52.75.02.21.7-1.7-0.4
Stereotopy head waving bouts, day 31.21.41.8-1.3-1.31.30.8
Stereotopy head waving duration, day 32.12.54.3-2.1-1.61.60.6
Locomotion velocity, session 72.93.14.01.72.0-2.0-1.3
Locomotion distance, session 70.40.50.70.60.8-0.8-0.6
Stereotopy head waving bouts, day 70.10.10.1-0.2-0.20.2-0.4
Stereotopy head waving duration, day 70.00.00.1-0.20.0-0.1-0.3
Locomotion velocity, session 80.40.51.60.4-0.20.31.3
Locomotion distance, session 81.92.75.92.41.6-1.50.0
Degree of sensitization distance2.72.75.5-2.3-1.71.60.3
Degree of sensitization stereotypy0.70.81.50.50.8-0.8-1.2
Conditioned locomotion2.32.63.2-1.5-1.81.81.4
Cocaine response after cond. corrected3.23.66.5-2.5-2.02.00.3
Cocaine response after cond. not corrected2.02.24.4-2.1-1.51.4-0.2
Cocaine response before conditioning2.12.63.21.51.8-1.8-1.3
Saline control response0.00.00.10.1-0.20.30.2
Bone: connectivity density0.81.22.21.51.2-1.1-0.3
Bone: cortical apparent density0.70.92.2-0.20.7-0.8-1.5
Bone: cortical area3.55.37.32.72.6-2.5-1.1
Bone: cortical porosity0.80.80.9-0.9-0.90.90.9
Bone: cortical porosity2.12.32.5-1.6-1.61.61.2
Bone: cortical thickness2.03.45.12.32.0-1.9-0.9
Bone: cortical thickness0.70.81.81.30.6-0.50.8
Bone: cortical tissue density0.50.71.9-0.40.5-0.6-1.4
Condit. Reinf. active minus inactive responses1.01.12.1-1.5-1.11.00.4
Condit. Reinf. active-inactive response ratio1.31.43.3-1.8-1.11.10.1
Condit. Reinf. active responses0.10.10.3-0.5-0.20.20.3
Condit. Reinf. inactive responses0.80.91.51.21.0-1.00.3
Incentive salience index mean0.10.20.4-0.6-0.30.20.4
Condit. Reinf. lever presses0.50.70.90.81.0-1.00.4
Condit. Reinf. active minus inactive responses0.30.30.80.90.4-0.30.5
Condit. Reinf. active-inactive response ratio1.71.72.2-1.3-1.51.50.9
Condit. Reinf. active responses2.73.76.72.62.1-2.00.1
Condit. Reinf. inactive responses7.89.613.53.73.5-3.4-0.8
Condit. Reinf. lever presses2.12.96.12.51.6-1.40.9
Condit. Reinf. lever reinforcers received2.63.76.42.52.1-2.00.0
Conditioned reinforcement - actives0.40.40.60.40.7-0.7-0.5
Conditioned reinforcement - inactives0.91.01.21.11.1-1.0-0.9
Conditioned locomotion0.91.01.50.61.2-1.2-1.0
Patch foraging indifference point 0 sec1.11.83.61.91.3-1.2-0.4
Patch foraging indifference point AUC2.12.43.51.91.6-1.6-1.0
Delay disc. indifference point, 0s delay0.20.30.70.5-0.10.20.8
Delay disc. indifference point, 16s delay0.00.00.0-0.10.1-0.10.2
Delay disc. indifference point, 2s delay0.20.20.3-0.3-0.50.50.3
Delay disc. indifference point, 24s delay0.30.30.4-0.6-0.50.40.5
Delay disc. indifference point, 4s delay0.20.20.2-0.4-0.40.50.2
Delay disc. indifference point, 8s delay0.20.20.5-0.0-0.30.30.7
Indifference point function ln k3.14.46.0-1.6-2.12.12.4
Indifference point function log k3.14.46.0-1.6-2.12.12.4
Patch foraging total patch changes 0 sec0.91.53.41.81.2-1.1-0.1
Patch foraging total patch changes 12 sec3.44.45.52.32.2-2.2-1.6
Patch foraging total patch changes 18 sec3.14.05.22.32.1-2.1-1.4
Patch foraging total patch changes 24 sec2.93.55.92.41.8-1.8-1.3
Patch foraging total patch changes 6 sec4.66.88.02.82.5-2.5-2.6
Patch foraging time to switch 0 sec0.40.62.1-0.40.2-0.3-1.4
Patch foraging water rate 0 sec0.81.32.7-0.3-1.01.11.6
Patch foraging water rate 12 sec0.71.13.50.7-0.40.61.9
Patch foraging water rate 18 sec0.70.92.40.80.5-0.41.6
Patch foraging water rate 24 sec1.62.23.8-1.0-1.41.41.9
Patch foraging water rate 6 sec1.82.75.3-0.7-1.51.62.3
Seeking ratio, delayed vs. immediate footshock0.80.92.51.60.8-0.7-0.0
Distance traveled before self-admin6.36.78.22.22.8-2.9-2.4
Distance traveled after self-admin4.95.46.52.42.6-2.5-1.8
Extensor digitorum longus weight0.31.33.82.00.8-0.60.7
Bone: elastic displacement0.30.41.21.10.5-0.4-0.0
Bone: elastic work0.81.12.61.61.0-0.9-0.1
Bone: endosteal estimation1.12.33.21.51.8-1.8-0.8
Bone: endosteal perimeter0.71.42.51.61.3-1.20.2
Epididymis fat weight0.00.00.1-0.3-0.10.10.1
Delta time in closed arm before/after self-admin0.10.10.2-0.5-0.30.20.0
Delta time in open arm before/after self-admin0.10.10.3-0.5-0.10.1-0.5
Diff in mean of infusions in LGA sessions0.00.00.1-0.30.0-0.0-0.1
Delay discount exponential model param0.20.20.30.40.5-0.5-0.5
Extinction: sum of active levers before priming1.00.91.70.80.9-0.9-1.3
Active lever presses in extinction session 60.20.20.6-0.4-0.20.1-0.8
Bone: final force2.94.76.02.42.4-2.4-1.2
Bone: final moment3.15.07.02.62.5-2.4-1.0
Food consumed during 24 hour testing period0.50.62.0-0.40.3-0.3-1.4
Glucose1.11.64.9-1.20.1-0.2-2.2
Heart weight0.60.82.7-0.00.4-0.5-1.6
Delay discount hyperbolic model param0.20.20.30.40.5-0.5-0.5
Intermittent access intake day 1-15 change1.01.01.81.31.0-0.90.7
Intermittent access intake escalation0.60.60.70.80.8-0.80.6
Intermittent access intake escalation 20.30.30.60.50.5-0.50.8
Intermitt. access day 1 inactive lever presses5.05.46.62.02.6-2.6-2.1
Intermitt. access day 15 inactive lever presses2.12.33.01.41.7-1.7-1.2
Intermitt. access escalation Index1.21.12.61.61.0-0.9-0.3
Intermittent access day 1 total infusions3.13.65.81.21.9-2.0-2.4
Intermittent access day 15 total infusions3.53.95.21.82.3-2.3-1.5
Intermittent access terminal intake (last 3 days)2.73.04.21.52.1-2.1-1.1
Intermittent access total infusions2.62.93.71.31.9-1.9-1.6
Intermittent access day 1 locomotion0.10.10.20.50.3-0.3-0.3
Intermittent access day 15 total locomotion0.00.00.0-0.10.00.00.0
Intermittent access total locomotion0.50.60.91.00.9-0.8-0.3
Intermittent access standard deviation3.03.24.11.82.0-2.0-1.3
Left kidney weight7.521.233.62.94.6-4.7-5.8
Right kidney weight3.18.817.11.42.8-2.9-4.1
Cocaine induced anxiety0.10.10.4-0.6-0.10.0-0.1
Post-drug Anxiety1.41.62.8-0.8-1.21.21.7
Baseline Anxiety1.51.63.70.3-1.01.21.9
Tail length1.33.95.20.82.2-2.3-2.3
Length with tail2.07.310.31.42.8-3.0-3.2
Length without tail1.53.33.61.61.9-1.9-1.9
Times rat made contact with spout0.00.00.1-0.00.0-0.1-0.3
Lifetime Intake1.92.22.81.01.6-1.7-1.5
Liver weight, left3.04.76.31.42.4-2.5-2.2
Liver weight, right2.74.55.51.72.3-2.3-2.0
Locomotor activity4.26.79.73.12.8-2.7-1.3
Locomotor testing distance2.23.75.42.32.1-2.0-1.0
Locomotor testing rearing3.14.87.82.82.4-2.3-0.8
Locomotion in novel chamber1.41.73.61.91.2-1.1-0.8
Locomotion in novel chamber post-restriction0.40.50.80.90.7-0.7-0.5
Fecal boli incidents, locomotor time 15.35.88.02.22.3-2.3-2.8
Change in fecal boli incidents, locomotor task7.97.48.0-2.6-2.82.82.6
Time >=10cm from walls, locomotor time 11.11.12.10.41.0-1.1-1.5
Bouts of movement, locomotor time 10.50.50.8-0.6-0.90.90.4
Total resting periods, locomotor time 10.40.50.7-0.6-0.90.80.1
Rest time, locomotor task time 11.92.14.0-2.0-1.21.1-1.4
Distance moved, locomotor task time 10.80.91.61.30.6-0.51.2
Vertical activity count, locomotor time 11.81.93.81.91.0-0.81.4
Time >=10cm from walls, locomotor time 20.40.51.40.20.4-0.5-1.2
Bouts of movement, locomotor time 21.51.62.1-1.5-1.51.40.5
Total resting periods, locomotor time 22.42.63.6-1.9-1.81.80.6
Rest time, locomotor task time 21.61.84.1-2.0-1.10.9-1.0
Distance moved, locomotor task time 20.80.91.31.11.1-1.0-0.3
Vertical activity count, locomotor time 21.61.73.51.91.3-1.20.7
Light reinforcement 10.71.32.21.51.2-1.2-0.2
Light reinforcement 20.10.20.50.70.2-0.20.4
Bone: marrow area1.02.23.11.41.8-1.8-0.8
Bone: maximum diameter2.34.25.62.42.3-2.3-0.7
Bone: maximum force3.15.37.22.72.6-2.6-0.8
Bone: maximum moment3.35.78.62.92.7-2.6-0.6
Mean time between licks in bursts0.20.31.10.3-0.30.31.0
Mean num. licks in bursts0.30.40.60.50.5-0.5-0.8
Cd content in liver1.71.93.31.81.3-1.3-0.9
Co content in liver0.40.51.21.10.7-0.6-0.2
Cu content in liver0.30.40.8-0.9-0.60.6-0.2
Fe content in liver0.20.31.00.3-0.00.11.0
K content in liver0.50.50.6-0.8-0.70.70.6
Mg content in liver0.00.00.1-0.3-0.20.2-0.1
Mn content in liver0.20.30.40.50.6-0.60.1
Na content in liver1.01.11.81.31.2-1.10.3
Rb content in liver0.70.82.7-0.10.5-0.6-1.6
Se content in liver2.32.84.8-2.2-1.81.80.3
Sr content in liver1.21.12.51.60.7-0.51.1
Zn content in liver2.22.42.91.31.6-1.6-1.7
Bone: minimum diameter1.73.24.11.52.0-2.0-1.6
Time in familiar zone, hab. session 10.60.61.40.40.6-0.6-1.2
Time in novel zone, hab. session 10.20.20.2-0.5-0.40.40.1
Total zone transitions, hab. session 10.50.71.91.40.7-0.70.1
Total locomotion distance, hab. session 10.71.02.41.60.9-0.80.2
Locomotion velocity, hab. session 10.50.71.81.30.6-0.60.7
Time in familiar zone, hab. session 20.20.20.40.40.6-0.6-0.2
Time in novel zone, hab. session 20.80.81.2-0.9-1.11.10.6
Total zone transitions, hab. session 21.11.43.31.80.8-0.61.2
Total locomotion distance, hab. session 21.01.32.61.50.4-0.31.6
Locomotion velocity, hab. session 21.21.63.61.90.8-0.61.4
Novel to familiar place preference ratio0.70.71.3-1.1-0.30.2-1.1
Novelty place preference0.70.71.8-1.0-0.0-0.1-1.3
Time in novel zone, NPP test0.80.82.2-1.0-0.1-0.0-1.5
Total zone transitions, NPP test0.50.71.61.10.2-0.11.3
Total locomotion distance, NPP test0.50.61.31.00.3-0.21.1
Locomotion velocity, NPP test0.70.92.11.20.3-0.21.4
Intraocular pressure1.21.64.02.01.2-1.1-0.0
Delta distance traveled before/after self-admin0.00.00.10.30.1-0.10.0
Delta ambulatory time before/after self-admin0.00.00.10.0-0.30.30.1
Parametrial fat weight0.61.22.0-1.4-1.21.10.2
Pavlov. Cond. lever latency0.40.51.4-0.7-0.20.1-1.2
Pavlov. Cond. magazine entry latency0.30.30.60.80.6-0.6-0.3
Pavlov. Cond. change in total contacts0.40.41.30.4-0.20.21.2
Pavlov. Cond. index score0.30.40.70.90.6-0.50.3
Pavlov. Cond. latency score0.30.30.70.80.5-0.40.5
Pavlov. Cond. lever contacts0.70.82.80.5-0.20.21.7
Pavlov. Cond. magazine entry number1.92.43.0-1.7-1.71.70.8
Pavlov. Cond. intertrial magazine entries6.57.910.3-3.2-3.03.01.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.30.50.2-0.10.6
Pavlov. Cond. response bias0.60.71.41.20.9-0.80.3
Pavlov. Cond. lever latency1.52.04.0-2.0-1.41.3-0.5
Pavlov. Cond. magazine entry latency0.60.71.6-0.4-0.70.71.3
Pavlov. Cond. change in total contacts1.31.73.11.81.3-1.20.7
Pavlov. Cond. index score0.50.61.11.00.4-0.31.0
Pavlov. Cond. latency score0.40.51.40.90.2-0.11.2
Pavlov. Cond. lever contacts1.72.44.42.11.6-1.50.1
Pavlov. Cond. magazine entry number0.10.10.2-0.4-0.20.2-0.3
Pavlov. Cond. intertrial magazine entries1.01.33.5-1.9-0.90.8-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.71.21.10.5-0.41.1
Pavlov. Cond. response bias0.91.22.41.51.1-1.00.6
Time in closed arm before self-admin4.24.75.81.62.4-2.4-2.2
Time in closed arm after self-admin0.70.71.20.10.9-0.9-1.1
Time in open arm before self-admin0.80.81.3-0.5-0.91.01.2
Time in open arm after self-admin1.82.03.0-1.7-1.51.50.6
Bone: periosteal estimation2.65.47.12.52.7-2.6-1.1
Bone: periosteal perimeter3.05.17.42.72.5-2.4-0.8
Bone: post-yield work0.00.10.1-0.30.3-0.30.1
Progressive ratio test 1 active lever presses0.70.81.00.51.0-1.0-1.0
Progressive ratio test 1 breakpoint0.80.91.00.71.0-1.0-1.0
Progressive ratio test 1 inactive lever presses1.11.21.90.81.1-1.1-1.4
Progressive ratio test 2 active lever presses2.72.93.41.31.8-1.8-1.8
Progressive ratio test 2 breakpoint2.93.23.91.41.9-1.9-2.0
Progressive ratio test 2 inactive lever presses3.94.56.81.52.1-2.1-2.6
Incentive Sensitization - Responses4.54.55.12.02.2-2.3-2.0
Incentive Sensitization - Breakpoint4.14.24.81.92.1-2.2-2.0
Sum of active levers in priming session hrs 5-60.20.20.60.30.3-0.3-0.8
Progressive ratio0.10.10.2-0.20.2-0.2-0.4
Food seeking constrained by brief footshock0.70.92.6-0.60.4-0.6-1.6
Seeking ratio, punishment vs. effort0.00.00.1-0.10.1-0.1-0.4
Retroperitoneal fat weight0.51.72.2-1.2-1.51.50.9
Reaction time number correct1.11.61.8-1.3-1.31.31.1
Reaction time mean minus median0.60.82.20.50.6-0.6-1.5
Reaction time mean minus median AUC1.01.33.30.50.9-0.9-1.8
Reaction time num false alarms0.20.30.50.70.6-0.5-0.1
Reaction time num false alarms AUC0.10.10.30.50.3-0.20.3
Reaction time trials correct on left1.11.61.8-1.3-1.31.31.1
Reaction time trials on left1.21.71.8-1.3-1.41.41.1
Reaction time mean0.30.40.80.40.6-0.6-0.9
Reaction time mean AUC0.00.10.2-0.10.1-0.1-0.4
Median of all reaction times0.00.00.10.00.2-0.2-0.3
Reaction time omissions0.00.00.00.10.1-0.1-0.2
Reaction time false alarm rate0.40.61.01.00.8-0.8-0.2
Reaction time premature initiation rate0.50.61.0-0.1-0.91.00.8
Reaction time premature initiations1.11.52.2-0.5-1.41.51.3
Std. dev. reaction times0.30.41.10.50.5-0.5-1.0
Reaction time trials completed1.21.71.8-1.3-1.41.41.1
Reaction time trials AUC0.91.31.5-1.2-1.21.20.9
Run reversals in cocaine runway, females0.70.70.91.00.8-0.8-0.8
Run reversals in cocaine runway, males0.90.92.80.10.6-0.7-1.7
Latency to leave start box in cocaine runway0.80.80.9-0.8-0.90.91.0
Latency to leave start box in cocaine runway, F0.10.10.2-0.0-0.30.30.5
Latency to leave start box in cocaine runway, M3.02.93.7-1.9-1.81.71.3
Std. dev. time between licks in bursts0.91.12.71.60.9-0.80.5
Total sessions with >9 infusions1.51.72.41.11.5-1.5-0.8
Short access day 1 total inactive lever presses0.40.51.01.00.6-0.6-0.4
Short access day 10 total inactive lever presses3.43.84.42.12.0-2.0-1.7
Short access day 1 total infusions2.32.42.81.31.7-1.7-1.5
Short access day 10 total infusions1.31.52.80.61.2-1.2-1.7
Short access total infusions0.91.01.70.41.0-1.0-1.3
Short access day 1 locomotion0.00.00.10.20.00.00.4
Short access day 10 total locomotion1.41.61.91.41.3-1.2-1.2
Short access total locomotion0.20.30.30.60.5-0.5-0.4
One hour access (0.3 mA shock)3.84.56.02.12.4-2.4-1.3
Compulsive drug intake1.91.92.51.31.6-1.6-0.9
One hour access (shock baseline)1.41.72.41.51.4-1.4-0.6
Social response proportion0.20.30.4-0.5-0.60.6-0.1
Social responses1.01.32.41.61.2-1.1-0.3
Social time0.10.10.50.0-0.10.10.7
Soleus weight1.85.312.23.52.2-2.00.7
Bone: stiffness2.84.56.02.32.5-2.4-0.9
Tibialis anterior weight1.24.110.33.21.8-1.60.4
Time to tail flick, vehicle, before self-admin2.32.32.7-1.5-1.61.71.3
Time to tail flick, vehicle, after self-admin0.50.61.3-1.1-0.70.60.4
Time to tail flick, test, before self-admin0.10.10.30.60.3-0.2-0.1
Time to tail flick, test, after self-admin0.20.20.4-0.20.4-0.4-0.6
Delta time to tail flick, vehicle, before/after SA0.40.40.60.40.7-0.7-0.8
Delta time to tail flick, test, before/after SA0.20.20.5-0.7-0.20.20.5
Tibia length0.92.63.51.51.9-1.9-1.0
Ambulatory time before self-admin5.25.47.02.02.6-2.7-1.9
Ambulatory time after self-admin4.65.06.22.32.5-2.5-1.6
Bone: tissue strength0.30.30.50.70.6-0.50.2
Total heroin consumption0.80.91.70.80.9-0.9-1.3
Bone: trabecular number0.40.71.71.30.5-0.40.7
Bone: trabecular spacing1.11.42.6-1.6-1.21.20.1
Bone: trabecular thickness1.41.72.11.11.5-1.5-1.2
Bone: trabecular tissue density0.20.30.5-0.10.5-0.5-0.7
Water consumed over 24 hours0.10.10.2-0.5-0.40.40.1
Number of responses in last shaping day0.00.10.10.10.3-0.3-0.2