Hub : Genes

Wnt3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Wnt3 0.03 0.01 1.9e-03 0.03 0.01 0.02 0.01 7.3e-04 1.1e-02 2.6e-03 1.8e-02
2 pVTA alternative TSS XM_017597028.3 0.09 0.05 7.6e-04 0.02 0.04 0.03 0.03 7.0e-03 2.3e-04 1.1e-03 1.6e-03
3 pVTA alternative TSS NM_001105715.2 0.08 0.04 1.4e-03 0.02 0.04 0.03 0.03 1.5e-02 5.5e-04 2.4e-03 3.1e-03
4 PL alternative TSS XM_017597028.3 0.02 0.02 9.3e-03 0 0.01 0 0 1.6e-01 6.3e-02 9.4e-02 1.5e-01
5 pVTA isoform ratio XM_017597028.3 0.08 0.05 3.0e-03 0.01 0.03 0.03 0.02 5.6e-02 1.1e-03 3.6e-03 5.9e-03
6 LHb mRNA stability Wnt3 0.32 0.12 8.9e-07 0.22 0.23 0.17 0.25 6.1e-06 3.3e-06 8.0e-05 1.0e-06
7 OFC gene expression Wnt3 0.19 0.1 2.9e-03 0.1 0.09 0.03 0.07 1.8e-03 3.5e-03 6.9e-02 9.9e-03
8 pVTA isoform ratio NM_001105715.2 0.08 0.05 4.3e-03 0.01 0.03 0.02 0.02 6.5e-02 1.4e-03 6.4e-03 8.2e-03
9 Brain mRNA stability Wnt3 0.13 0.06 2.0e-13 0.14 0.15 0.15 0.15 9.9e-13 7.0e-14 3.6e-14 3.8e-14
10 PL isoform ratio NM_001105715.2 0.03 0.02 6.9e-03 -0 0 0 0 3.9e-01 7.7e-02 7.7e-02 2.2e-01
11 PL isoform ratio XM_017597028.3 0.03 0.02 8.6e-03 -0 0 0 0 5.6e-01 1.1e-01 9.7e-02 2.9e-01
12 IC gene expression Wnt3 0.3 0.11 3.5e-13 0.2 0.27 0.27 0.29 6.5e-09 1.4e-11 1.0e-11 1.2e-12
13 NAcc gene expression Wnt3 0.06 0.03 5.5e-12 0.09 0.08 0.08 0.08 3.9e-13 6.7e-12 9.7e-13 1.1e-12
14 PL gene expression Wnt3 0.15 0.06 0.0e+00 0.21 0.21 0.22 0.21 1.7e-22 4.2e-22 3.5e-24 1.1e-22
15 PL alternative TSS NM_001105715.2 0.02 0.02 9.1e-03 -0 0 0 -0 5.3e-01 3.3e-01 2.5e-01 3.8e-01
16 Brain isoform ratio XM_017597028.3 0.04 0.02 1.6e-04 0.03 0.04 0.03 0.03 1.2e-03 1.3e-04 6.0e-04 8.4e-04
17 Brain isoform ratio NM_001105715.2 0.04 0.02 1.4e-04 0.03 0.04 0.03 0.03 1.1e-03 1.2e-04 6.1e-04 7.4e-04
18 Brain alternative TSS NM_001105715.2 0.04 0.02 1.5e-04 0.03 0.04 0.02 0.03 9.5e-04 8.8e-05 2.7e-03 1.7e-03
19 Brain alternative TSS XM_017597028.3 0.04 0.02 1.4e-04 0.03 0.04 0.02 0.03 8.4e-04 8.4e-05 2.4e-03 1.4e-03
20 BLA gene expression Wnt3 0.1 0.06 8.5e-04 0.1 0.05 0.07 0.08 9.4e-06 1.1e-03 8.7e-05 5.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density2.14.07.3-1.62.6-2.72.52.7-1.6-0.4-2.72.02.7-2.71.5-1.9-1.32.41.3-1.3-1.21.2-1.1
Area under the delay curve0.00.00.0-0.0-0.10.1-0.2-0.10.1-0.00.10.0-0.10.2-0.10.10.0-0.0-0.00.0-0.00.00.2
BMI with tail0.51.75.40.2-1.31.4-1.2-1.21.7-1.41.3-1.4-0.70.7-0.62.31.2-1.5-1.31.41.4-1.41.0
BMI without tail0.10.44.4-1.3-0.30.40.2-0.30.0-2.10.4-0.20.1-0.10.81.0-0.3-0.60.00.00.1-0.1-0.1
Body weight0.31.210.4-1.80.1-0.00.30.20.5-3.2-0.1-0.31.4-1.30.51.80.7-0.1-0.70.70.7-0.80.3
Weight adjusted by age0.00.10.7-0.3-0.20.3-0.4-0.3-0.10.10.3-0.20.00.0-0.10.20.5-0.3-0.20.20.1-0.10.8
Bone surface3.46.812.2-3.13.5-3.53.23.4-2.7-1.7-3.42.83.3-3.22.1-2.1-1.82.51.7-1.7-1.61.6-0.8
Bone volume3.16.211.3-2.63.4-3.43.13.4-2.4-1.4-3.32.63.1-3.12.0-2.1-1.72.61.7-1.7-1.61.5-0.9
Breakpoint value in progressive ratio session0.30.61.5-0.6-0.10.10.4-0.2-0.8-1.00.20.7-0.40.40.9-0.8-1.00.21.2-1.2-1.21.2-0.9
Number of licking bursts0.82.34.70.9-1.61.6-1.7-1.61.5-0.01.6-1.4-2.12.2-1.21.71.5-2.1-1.41.41.3-1.31.1
Context. condit. distance diff. score0.80.91.61.3-1.11.1-1.3-1.01.20.41.0-0.9-0.90.9-0.70.90.9-1.0-0.90.90.9-0.90.8
Locomotion velocity, session 10.80.91.6-0.70.9-0.91.00.9-1.0-0.4-0.91.10.8-0.81.0-1.3-1.30.91.0-1.0-1.01.0-0.7
Locomotion distance, session 10.20.30.5-0.30.5-0.50.70.5-0.3-0.3-0.50.50.3-0.30.6-0.6-0.70.50.6-0.6-0.50.6-0.7
Locomotion velocity, session 20.91.12.7-0.21.0-1.01.01.1-0.80.4-1.11.30.8-0.80.9-1.6-1.11.21.2-1.2-1.11.2-0.9
Locomotion distance, session 20.40.51.3-0.10.2-0.30.70.2-0.4-0.3-0.20.70.2-0.20.9-0.9-1.10.61.0-1.0-1.01.0-1.0
Locomotion velocity, session 30.40.51.30.11.0-0.90.30.9-0.11.1-1.0-0.11.0-1.0-0.5-0.20.30.6-0.60.60.7-0.70.8
Locomotion distance, session 30.70.82.60.50.3-0.2-0.50.20.51.2-0.2-0.7-0.20.2-1.10.51.2-0.7-1.21.21.2-1.31.6
Stereotopy head waving bouts, day 30.60.72.30.41.0-1.00.81.1-0.30.6-1.20.71.5-1.50.1-0.9-0.31.50.3-0.3-0.20.3-0.5
Stereotopy head waving duration, day 30.20.31.10.8-0.10.00.30.00.2-0.0-0.10.30.7-0.80.3-0.4-0.31.10.5-0.5-0.50.5-1.0
Locomotion velocity, session 70.30.31.20.90.00.0-0.50.10.61.1-0.2-0.40.2-0.2-0.70.10.4-0.0-0.70.70.7-0.70.6
Locomotion distance, session 70.10.20.70.9-0.30.3-0.5-0.30.40.60.3-0.4-0.10.1-0.40.10.3-0.2-0.30.30.3-0.30.5
Stereotopy head waving bouts, day 70.20.31.00.60.4-0.50.40.50.00.6-0.50.40.8-0.80.0-0.60.11.00.2-0.2-0.20.3-0.6
Stereotopy head waving duration, day 70.20.31.91.4-0.40.3-0.1-0.30.60.90.2-0.10.3-0.4-0.2-0.20.30.70.1-0.1-0.10.2-0.7
Locomotion velocity, session 80.10.10.9-0.0-0.20.30.1-0.10.1-0.90.20.00.1-0.20.60.1-0.6-0.00.2-0.2-0.10.2-0.4
Locomotion distance, session 80.20.20.91.0-0.70.7-0.3-0.60.4-0.00.60.0-0.40.30.4-0.3-0.5-0.00.4-0.4-0.40.4-0.6
Degree of sensitization distance0.40.51.9-0.1-0.90.8-0.0-0.80.0-1.40.80.20.1-0.20.80.1-0.60.40.7-0.7-0.70.7-1.2
Degree of sensitization stereotypy0.10.10.80.9-0.20.1-0.2-0.10.50.90.1-0.10.1-0.1-0.4-0.10.50.3-0.20.20.2-0.1-0.1
Conditioned locomotion0.10.10.20.4-0.40.3-0.0-0.40.50.10.3-0.20.1-0.20.00.30.20.20.1-0.1-0.10.1-0.4
Cocaine response after cond. corrected0.50.82.1-0.21.1-1.00.11.10.00.8-1.1-0.10.7-0.6-1.00.10.8-0.1-1.11.11.1-1.21.4
Cocaine response after cond. not corrected0.91.23.6-0.71.9-1.80.61.9-0.71.0-1.90.51.3-1.2-0.6-0.60.20.5-0.60.60.7-0.81.4
Cocaine response before conditioning0.91.12.0-0.81.1-1.21.11.1-1.4-0.0-1.21.30.8-0.81.0-1.4-1.21.01.1-1.1-1.11.1-0.6
Saline control response0.20.31.1-0.5-0.40.50.1-0.5-0.3-1.10.60.0-0.50.50.9-0.1-1.0-0.50.6-0.6-0.60.6-0.3
Bone: connectivity density2.94.67.4-2.02.5-2.62.62.5-2.1-0.8-2.52.32.7-2.71.8-2.1-1.72.61.7-1.7-1.71.7-1.4
Bone: cortical apparent density0.50.86.22.5-0.20.1-0.6-0.10.82.5-0.0-0.4-0.40.4-1.0-0.50.30.1-0.20.20.2-0.2-0.0
Bone: cortical area1.93.19.2-1.83.0-3.02.13.0-1.4-0.4-2.91.42.3-2.30.7-1.2-0.71.40.4-0.4-0.20.20.5
Bone: cortical porosity8.08.719.8-4.53.9-3.83.33.8-3.8-2.5-3.73.33.1-3.02.5-2.6-2.41.81.9-1.9-1.71.60.1
Bone: cortical porosity4.75.213.9-3.73.4-3.22.53.3-2.8-2.0-3.12.32.6-2.41.6-1.7-1.61.00.9-0.8-0.70.60.9
Bone: cortical thickness1.22.16.91.02.0-2.00.52.00.52.6-2.1-0.21.2-1.2-1.5-0.31.00.5-1.31.31.5-1.51.5
Bone: cortical thickness0.91.23.40.51.6-1.60.61.6-0.31.8-1.70.41.5-1.5-0.8-1.00.21.2-0.30.30.3-0.30.5
Bone: cortical tissue density0.50.75.92.4-0.20.2-0.6-0.10.72.40.0-0.4-0.50.4-0.9-0.50.20.1-0.20.10.1-0.1-0.1
Condit. Reinf. active minus inactive responses1.11.32.5-1.40.3-0.30.90.3-1.4-1.5-0.21.40.2-0.21.6-1.1-1.20.61.5-1.5-1.61.5-1.2
Condit. Reinf. active-inactive response ratio0.30.30.8-0.4-0.30.30.0-0.4-0.6-0.70.40.6-0.30.40.7-0.4-0.30.10.7-0.7-0.90.9-0.5
Condit. Reinf. active responses1.72.23.8-1.60.8-0.81.40.8-1.7-1.6-0.71.80.5-0.52.0-1.6-1.80.91.9-1.9-1.91.9-1.5
Condit. Reinf. inactive responses1.41.92.9-1.11.5-1.51.71.6-1.3-0.8-1.61.51.2-1.21.3-1.5-1.71.21.3-1.3-1.21.2-1.1
Incentive salience index mean1.41.83.2-1.50.8-0.91.20.8-1.8-1.2-0.81.80.4-0.31.7-1.5-1.50.81.7-1.7-1.71.7-1.1
Condit. Reinf. lever presses0.91.42.4-1.11.2-1.21.31.2-1.5-0.4-1.21.50.4-0.41.3-1.5-1.50.61.3-1.3-1.21.2-0.7
Condit. Reinf. active minus inactive responses3.85.88.4-2.62.4-2.52.62.4-2.9-1.7-2.32.82.3-2.22.4-2.6-2.52.12.4-2.5-2.42.4-1.4
Condit. Reinf. active-inactive response ratio1.82.85.4-2.21.6-1.71.81.5-2.3-1.5-1.52.01.3-1.21.7-1.8-1.71.31.8-1.8-1.81.8-0.9
Condit. Reinf. active responses5.57.910.3-2.92.3-2.33.02.2-3.2-2.3-2.23.22.7-2.63.1-3.0-3.12.73.1-3.1-3.13.1-2.3
Condit. Reinf. inactive responses2.63.96.0-1.31.1-1.21.91.2-1.8-1.4-1.22.11.8-1.92.4-2.2-2.52.12.4-2.4-2.42.4-2.4
Condit. Reinf. lever presses1.62.33.5-1.61.4-1.41.61.3-1.9-0.7-1.31.71.1-1.11.7-1.7-1.71.21.8-1.8-1.81.8-1.1
Condit. Reinf. lever reinforcers received4.96.99.2-2.72.3-2.42.82.3-3.0-2.0-2.23.02.6-2.52.9-2.9-2.82.52.9-2.9-2.92.8-2.0
Conditioned reinforcement - actives0.10.41.10.1-0.80.8-0.3-0.9-0.1-0.80.9-0.1-1.11.10.40.3-0.3-0.50.3-0.3-0.30.4-0.5
Conditioned reinforcement - inactives0.30.82.5-1.00.9-0.91.10.9-0.9-1.6-0.81.00.4-0.41.0-0.4-1.00.70.7-0.7-0.70.7-0.9
Conditioned locomotion0.30.43.7-1.1-0.20.20.2-0.2-0.7-1.90.30.60.1-0.10.80.0-0.30.10.4-0.4-0.50.5-0.5
Patch foraging indifference point 0 sec1.54.16.8-1.21.7-1.72.31.7-1.6-1.6-1.82.12.3-2.52.3-2.0-2.32.62.1-2.1-2.02.0-2.2
Patch foraging indifference point AUC0.20.41.4-0.3-1.00.9-0.3-1.00.3-1.21.0-0.1-0.70.70.30.60.1-0.30.2-0.2-0.30.2-0.5
Delay disc. indifference point, 0s delay0.20.20.50.2-0.50.5-0.1-0.50.2-0.40.50.4-0.30.40.5-0.5-0.50.20.6-0.7-0.70.7-0.7
Delay disc. indifference point, 16s delay0.30.51.60.3-0.20.3-0.7-0.20.50.30.3-0.7-0.00.0-0.80.91.0-0.5-0.90.90.9-0.91.3
Delay disc. indifference point, 2s delay2.12.43.5-1.61.1-1.21.71.1-1.6-1.4-1.11.80.9-0.91.8-1.6-1.61.81.8-1.8-1.91.9-1.8
Delay disc. indifference point, 24s delay0.10.10.4-0.3-0.30.4-0.4-0.3-0.2-0.40.3-0.1-0.60.6-0.00.4-0.0-0.7-0.10.10.0-0.00.2
Delay disc. indifference point, 4s delay0.00.00.10.20.2-0.2-0.10.20.10.0-0.20.2-0.10.1-0.0-0.3-0.10.10.1-0.1-0.10.10.3
Delay disc. indifference point, 8s delay0.00.10.60.30.2-0.1-0.10.10.10.8-0.2-0.10.1-0.1-0.40.00.00.1-0.20.20.2-0.20.2
Indifference point function ln k0.82.45.9-1.12.0-2.01.72.0-1.40.1-2.01.42.4-2.40.9-1.7-1.12.00.9-0.9-0.80.8-0.5
Indifference point function log k0.82.45.9-1.12.0-2.01.72.0-1.40.1-2.01.42.4-2.40.9-1.7-1.12.00.9-0.9-0.80.8-0.5
Patch foraging total patch changes 0 sec1.64.77.4-1.51.9-2.02.52.0-1.7-1.7-2.02.22.6-2.72.3-2.1-2.42.72.1-2.1-2.02.0-2.1
Patch foraging total patch changes 12 sec2.33.16.3-1.10.5-0.61.70.4-1.4-2.0-0.41.81.3-1.42.3-1.9-2.41.92.3-2.3-2.22.2-2.5
Patch foraging total patch changes 18 sec0.10.30.7-0.70.5-0.50.60.5-0.6-0.8-0.50.60.3-0.30.7-0.4-0.60.30.5-0.5-0.50.4-0.1
Patch foraging total patch changes 24 sec1.03.55.8-1.31.6-1.72.11.7-1.5-1.6-1.72.02.3-2.41.9-1.8-2.02.41.9-1.8-1.81.8-2.0
Patch foraging total patch changes 6 sec0.40.71.3-0.50.6-0.71.10.6-0.6-1.1-0.60.80.6-0.71.1-0.6-0.91.01.0-0.9-0.90.9-1.1
Patch foraging time to switch 0 sec0.10.51.60.4-0.20.2-0.7-0.20.20.70.2-0.6-1.01.1-0.70.40.4-1.3-0.60.60.6-0.61.3
Patch foraging water rate 0 sec0.20.92.4-0.70.6-0.71.00.8-0.4-1.2-0.81.01.4-1.41.0-0.7-0.71.50.7-0.7-0.80.8-1.2
Patch foraging water rate 12 sec0.20.82.50.60.5-0.5-0.30.60.90.5-0.6-0.60.9-0.9-1.21.01.60.5-1.21.21.1-1.10.9
Patch foraging water rate 18 sec0.61.24.70.21.4-1.41.11.5-0.20.7-1.60.52.1-2.20.2-0.7-0.41.90.3-0.3-0.20.3-0.7
Patch foraging water rate 24 sec0.30.52.90.40.9-0.90.30.9-0.11.7-1.0-0.10.7-0.8-0.5-0.7-0.10.6-0.30.30.3-0.30.5
Patch foraging water rate 6 sec1.31.94.4-1.21.4-1.51.51.5-1.1-0.9-1.51.32.1-2.11.1-1.2-0.92.11.0-1.0-1.01.0-1.3
Seeking ratio, delayed vs. immediate footshock1.21.73.9-0.2-1.61.6-1.3-1.60.8-0.81.7-1.3-1.71.7-0.61.91.2-2.0-1.01.11.0-1.00.9
Distance traveled before self-admin0.20.40.8-0.50.9-0.80.60.8-0.7-0.3-0.80.80.4-0.30.6-0.9-0.60.10.7-0.7-0.70.70.6
Distance traveled after self-admin0.10.20.90.3-0.50.5-0.4-0.50.40.90.5-0.5-0.70.8-0.30.00.1-0.8-0.20.20.2-0.20.5
Extensor digitorum longus weight5.120.229.63.7-5.45.4-5.2-5.44.91.45.4-5.1-4.84.7-3.85.14.2-4.9-3.93.93.7-3.72.8
Bone: elastic displacement0.30.41.5-0.10.9-0.90.30.9-0.11.2-0.90.00.7-0.6-0.3-0.30.40.4-0.40.40.4-0.50.6
Bone: elastic work1.21.63.8-1.42.0-1.91.51.9-1.20.2-1.91.11.7-1.60.7-1.2-0.81.10.4-0.4-0.30.30.2
Bone: endosteal estimation2.04.915.5-3.92.0-1.92.41.9-2.8-3.7-1.72.41.3-1.22.7-1.4-2.01.12.1-2.1-2.12.0-0.8
Bone: endosteal perimeter2.04.818.7-4.32.1-2.02.31.9-2.8-4.2-1.72.21.4-1.22.6-1.0-1.90.71.8-1.8-1.81.7-0.3
Epididymis fat weight0.00.20.7-0.1-0.60.6-0.1-0.60.5-0.60.6-0.40.1-0.20.20.80.10.10.0-0.0-0.00.0-0.5
Delta time in closed arm before/after self-admin1.71.63.81.20.3-0.3-0.70.51.31.7-0.5-1.4-0.20.1-1.41.11.2-0.8-1.81.82.0-1.91.9
Delta time in open arm before/after self-admin1.82.15.1-0.1-1.61.50.0-1.7-0.5-1.51.71.0-1.51.51.3-1.0-1.1-0.21.8-1.8-1.91.9-2.3
Diff in mean of infusions in LGA sessions0.30.51.2-0.4-0.20.20.4-0.3-0.5-0.90.30.7-0.40.40.9-0.5-0.70.11.0-1.1-1.11.1-0.9
Delay discount exponential model param0.00.00.10.10.1-0.10.20.1-0.10.1-0.1-0.00.2-0.30.0-0.10.00.20.0-0.00.00.0-0.2
Extinction: sum of active levers before priming0.20.31.40.2-0.70.7-0.4-0.70.20.00.7-0.3-1.21.2-0.10.1-0.3-0.9-0.00.00.1-0.1-0.4
Active lever presses in extinction session 60.60.63.4-1.20.0-0.00.5-0.1-0.6-1.80.20.7-0.30.31.0-0.3-0.9-0.50.8-0.8-0.80.8-0.4
Bone: final force1.82.98.6-1.12.9-2.92.02.9-1.20.0-2.91.52.0-2.00.7-1.5-0.91.50.6-0.6-0.40.40.1
Bone: final moment2.23.610.3-1.33.2-3.22.33.2-1.40.1-3.21.72.2-2.20.8-1.7-1.11.70.7-0.7-0.50.50.1
Food consumed during 24 hour testing period0.10.23.2-0.5-0.50.5-0.2-0.40.0-1.80.40.0-0.20.20.30.5-0.1-0.30.00.0-0.00.0-0.3
Glucose1.32.04.41.4-0.50.6-1.5-0.61.51.60.6-1.5-1.01.0-2.11.21.5-1.2-1.81.81.9-1.81.8
Heart weight1.22.04.90.4-0.30.4-1.0-0.41.8-0.10.4-1.6-0.10.1-1.32.21.9-1.2-2.12.12.1-2.11.6
Delay discount hyperbolic model param0.00.00.20.3-0.0-0.0-0.00.00.10.4-0.0-0.30.2-0.2-0.30.10.3-0.1-0.30.30.3-0.30.1
Intermittent access intake day 1-15 change0.21.03.10.1-0.20.3-0.9-0.20.30.60.2-1.1-0.90.9-1.10.90.7-1.4-1.41.41.5-1.51.8
Intermittent access intake escalation0.10.83.2-0.30.2-0.1-0.60.20.00.5-0.2-0.9-0.60.7-0.90.60.3-1.2-1.21.21.4-1.41.8
Intermittent access intake escalation 20.20.31.7-0.50.3-0.2-0.20.3-0.30.1-0.3-0.5-0.30.3-0.50.40.0-0.9-0.80.80.9-1.01.3
Intermitt. access day 1 inactive lever presses0.11.35.2-2.30.7-0.71.40.7-1.6-2.0-0.61.00.8-0.71.4-0.3-1.00.71.0-1.0-0.90.9-0.9
Intermitt. access day 15 inactive lever presses0.84.16.9-2.61.4-1.52.21.4-2.5-2.3-1.32.31.8-1.72.4-1.6-1.72.12.2-2.2-2.32.3-2.0
Intermitt. access escalation Index0.51.42.60.6-0.80.8-1.3-0.91.01.10.9-1.3-1.31.3-1.51.11.2-1.4-1.41.41.3-1.31.6
Intermittent access day 1 total infusions0.10.31.00.0-0.70.7-0.0-0.70.1-1.00.80.4-0.10.10.60.0-0.10.20.6-0.6-0.70.7-1.0
Intermittent access day 15 total infusions0.20.41.3-0.8-0.60.6-0.5-0.6-0.2-1.00.6-0.3-1.01.10.10.5-0.1-1.1-0.30.40.4-0.40.6
Intermittent access terminal intake (last 3 days)0.20.42.9-1.1-0.50.5-0.1-0.6-0.6-1.70.60.3-0.70.80.70.1-0.5-0.60.4-0.3-0.40.4-0.2
Intermittent access total infusions0.50.61.8-0.5-1.21.2-0.5-1.30.1-1.41.3-0.2-1.11.10.30.60.0-0.9-0.00.0-0.00.0-0.3
Intermittent access day 1 locomotion0.20.33.6-1.2-0.20.20.2-0.2-0.4-1.90.20.50.2-0.10.70.2-0.2-0.00.3-0.3-0.30.3-0.5
Intermittent access day 15 total locomotion0.10.42.0-0.7-0.80.9-0.3-0.8-0.1-1.40.8-0.0-0.90.90.50.5-0.2-0.8-0.10.10.1-0.1-0.1
Intermittent access total locomotion0.50.64.8-1.7-0.30.30.4-0.3-0.9-2.20.30.6-0.10.11.1-0.0-0.7-0.20.5-0.5-0.50.5-0.6
Intermittent access standard deviation0.10.41.3-0.6-0.30.30.4-0.3-0.7-1.10.30.5-0.50.51.0-0.3-1.0-0.20.7-0.7-0.60.6-0.8
Left kidney weight0.10.82.9-0.11.1-1.10.41.20.40.4-1.10.01.7-1.7-0.40.20.70.7-0.70.70.8-0.80.8
Right kidney weight0.11.02.2-0.10.6-0.6-0.10.61.00.3-0.6-0.61.1-1.2-1.01.01.40.1-1.41.41.5-1.51.2
Cocaine induced anxiety0.20.61.40.60.4-0.4-0.30.50.61.2-0.5-0.60.1-0.1-1.00.60.8-0.2-1.11.11.2-1.21.0
Post-drug Anxiety0.20.30.6-0.30.6-0.60.10.70.20.3-0.7-0.30.3-0.2-0.40.50.4-0.1-0.70.70.8-0.80.6
Baseline Anxiety0.30.52.9-1.4-0.10.10.4-0.2-0.7-1.70.30.5-0.20.30.9-0.0-0.4-0.00.8-0.8-0.80.8-0.7
Tail length0.84.46.5-2.62.1-2.12.52.1-2.2-2.1-2.12.12.4-2.42.2-1.7-1.72.11.9-1.9-1.91.8-1.5
Length with tail0.31.45.4-1.91.1-1.11.41.2-0.7-2.3-1.10.72.0-2.01.00.2-0.21.10.3-0.3-0.20.2-0.6
Length without tail0.31.54.10.5-0.50.5-0.8-0.41.8-0.80.5-1.20.7-0.8-1.12.02.0-0.2-1.71.71.7-1.70.9
Times rat made contact with spout0.10.20.8-0.00.2-0.2-0.20.30.20.0-0.3-0.1-0.40.4-0.30.20.1-0.6-0.50.50.6-0.60.9
Lifetime Intake0.30.42.4-0.7-0.80.8-0.1-0.9-0.1-1.50.90.2-0.50.50.60.2-0.3-0.40.3-0.3-0.30.3-0.6
Liver weight, left1.11.95.1-1.81.4-1.41.51.4-1.3-1.7-1.41.52.2-2.21.3-0.9-1.01.40.8-0.8-0.80.7-0.6
Liver weight, right0.61.01.60.31.2-1.20.21.20.51.3-1.2-0.31.2-1.2-1.10.31.00.3-1.11.11.2-1.21.0
Locomotor activity0.91.53.0-1.70.7-0.71.30.5-1.3-1.5-0.51.11.0-1.01.7-0.9-1.70.81.5-1.5-1.41.4-1.0
Locomotor testing distance1.12.65.4-2.21.1-1.11.70.9-2.0-1.5-0.91.71.1-1.12.1-1.7-2.31.01.9-1.9-1.91.8-0.9
Locomotor testing rearing0.41.65.1-1.50.4-0.30.90.2-1.4-1.4-0.21.30.4-0.42.0-1.4-2.30.31.7-1.7-1.71.6-0.6
Locomotion in novel chamber0.60.82.6-1.20.9-0.80.50.8-1.2-1.6-0.81.31.0-0.90.8-0.9-0.60.60.8-0.8-0.90.90.2
Locomotion in novel chamber post-restriction0.20.61.8-0.90.8-0.80.90.8-0.6-0.8-0.80.61.3-1.40.5-0.4-0.60.70.4-0.4-0.30.3-0.1
Fecal boli incidents, locomotor time 10.10.20.50.20.2-0.1-0.30.10.10.6-0.2-0.6-0.40.4-0.70.50.4-0.3-0.60.60.7-0.70.7
Change in fecal boli incidents, locomotor task0.10.10.2-0.20.2-0.20.30.2-0.0-0.4-0.20.40.4-0.40.3-0.3-0.30.20.3-0.3-0.30.3-0.1
Time >=10cm from walls, locomotor time 10.60.82.11.1-0.40.4-1.0-0.40.91.40.4-0.9-0.20.2-1.20.61.5-0.4-1.01.00.9-0.91.0
Bouts of movement, locomotor time 10.70.92.01.4-0.80.8-1.0-0.71.40.90.7-1.0-0.80.8-1.01.11.3-0.7-1.01.00.9-0.90.5
Total resting periods, locomotor time 10.91.02.11.4-0.70.7-1.1-0.61.40.90.6-1.1-0.50.5-1.21.31.4-0.7-1.21.21.1-1.10.8
Rest time, locomotor task time 10.10.10.60.7-0.20.2-0.2-0.20.40.80.2-0.20.2-0.3-0.50.10.50.2-0.30.30.2-0.20.2
Distance moved, locomotor task time 10.10.21.2-0.5-0.20.3-0.2-0.30.2-1.10.3-0.1-0.60.60.20.40.1-0.7-0.10.10.1-0.10.2
Vertical activity count, locomotor time 10.00.10.4-0.60.3-0.30.00.30.0-0.4-0.20.1-0.20.30.1-0.00.1-0.3-0.10.10.1-0.10.5
Time >=10cm from walls, locomotor time 20.10.41.0-0.41.0-0.90.31.0-0.4-0.3-0.90.40.9-0.90.3-0.3-0.10.40.0-0.0-0.10.00.8
Bouts of movement, locomotor time 20.10.30.8-0.30.9-0.90.60.8-0.40.6-0.80.10.9-0.9-0.2-0.00.30.7-0.00.00.0-0.0-0.1
Total resting periods, locomotor time 20.10.31.10.10.7-0.70.30.60.01.1-0.6-0.30.7-0.7-0.60.30.70.5-0.40.40.5-0.50.2
Rest time, locomotor task time 20.71.22.01.1-0.90.9-1.1-0.91.21.10.9-1.2-0.70.7-1.41.11.4-0.8-1.31.31.3-1.30.9
Distance moved, locomotor task time 20.00.10.2-0.30.3-0.30.10.2-0.1-0.5-0.20.2-0.00.10.3-0.0-0.3-0.30.2-0.2-0.20.20.4
Vertical activity count, locomotor time 20.30.71.1-0.80.9-0.90.90.9-0.8-0.5-0.91.00.6-0.51.0-0.9-1.00.70.9-0.9-0.90.9-0.4
Light reinforcement 10.62.85.4-1.41.0-1.11.91.0-1.4-1.4-1.01.62.2-2.31.8-1.5-1.42.31.7-1.7-1.71.7-2.3
Light reinforcement 21.32.94.8-1.31.5-1.62.11.5-1.7-1.0-1.51.91.5-1.51.6-1.8-1.42.21.8-1.8-1.81.8-2.2
Bone: marrow area1.94.815.3-3.92.0-2.02.31.9-2.7-3.6-1.72.41.3-1.22.7-1.4-2.01.02.0-2.0-2.02.0-0.7
Bone: maximum diameter1.93.97.7-2.72.8-2.72.32.7-2.2-1.8-2.62.11.9-1.81.8-1.6-1.61.31.3-1.3-1.21.2-0.0
Bone: maximum force1.32.57.8-1.82.8-2.72.02.7-1.3-0.6-2.71.31.7-1.70.7-1.0-0.81.00.4-0.4-0.20.20.4
Bone: maximum moment1.73.29.5-1.93.1-3.02.23.0-1.5-0.5-3.01.52.0-1.90.8-1.3-0.91.30.5-0.5-0.30.30.4
Mean time between licks in bursts0.63.88.11.2-1.61.6-1.9-1.52.30.01.6-2.2-1.71.7-1.82.82.5-2.0-2.32.32.3-2.31.8
Mean num. licks in bursts0.51.42.8-0.81.4-1.41.31.5-1.20.1-1.51.01.6-1.70.8-1.3-1.21.50.9-0.9-0.80.8-0.5
Cd content in liver2.52.86.22.5-2.42.4-2.0-2.32.00.92.2-1.5-2.42.3-1.01.10.9-1.5-0.70.70.6-0.5-0.1
Co content in liver1.11.24.20.5-2.01.9-1.2-2.00.5-0.22.0-0.4-1.61.6-0.10.50.4-1.00.2-0.2-0.40.4-0.5
Cu content in liver0.20.31.2-0.2-0.40.30.1-0.3-0.2-1.10.40.40.1-0.00.70.10.00.40.6-0.6-0.80.8-0.9
Fe content in liver0.20.21.91.4-0.40.3-0.3-0.20.40.50.10.2-0.0-0.00.2-0.30.00.50.3-0.3-0.40.4-0.6
K content in liver0.40.40.80.10.4-0.50.50.4-0.50.6-0.40.70.5-0.50.5-0.8-0.30.80.8-0.8-0.90.9-0.5
Mg content in liver0.40.52.31.5-0.60.5-0.4-0.60.31.30.50.1-0.60.6-0.1-0.60.00.40.6-0.7-0.80.8-0.9
Mn content in liver2.32.65.40.01.6-1.81.81.7-1.10.8-1.81.61.8-1.81.2-2.1-1.42.31.6-1.6-1.51.6-1.8
Na content in liver0.80.92.4-0.50.0-0.10.60.0-1.0-0.5-0.01.0-0.10.11.3-1.2-1.30.51.5-1.5-1.51.5-1.2
Rb content in liver0.30.31.31.1-0.40.3-0.1-0.50.21.00.40.0-0.10.10.1-0.5-0.20.50.7-0.7-0.80.8-0.9
Se content in liver2.52.95.62.4-2.01.9-2.0-1.92.11.31.9-1.8-1.81.8-1.51.71.7-1.6-1.41.41.3-1.30.8
Sr content in liver0.60.51.90.2-0.20.3-0.8-0.20.50.10.2-0.50.10.0-1.00.81.4-0.4-1.01.00.9-0.91.1
Zn content in liver0.20.30.70.8-0.20.3-0.6-0.20.40.90.2-0.2-0.70.7-0.7-0.00.4-0.7-0.40.40.3-0.30.6
Bone: minimum diameter3.15.917.4-4.22.8-2.82.82.7-2.8-3.7-2.52.52.5-2.42.5-1.2-1.81.61.7-1.7-1.61.5-0.6
Time in familiar zone, hab. session 11.21.43.61.1-1.51.6-1.3-1.51.3-0.21.5-1.0-1.91.9-0.51.00.2-1.7-0.50.50.5-0.50.4
Time in novel zone, hab. session 10.60.72.0-0.61.1-1.10.81.1-0.80.5-1.10.81.4-1.30.2-0.90.11.30.2-0.2-0.30.2-0.1
Total zone transitions, hab. session 11.21.72.51.3-1.41.4-1.5-1.31.60.41.3-1.4-1.41.4-1.21.41.3-1.4-1.31.31.3-1.31.0
Total locomotion distance, hab. session 10.50.61.2-0.90.8-0.90.90.9-0.7-0.9-0.90.91.1-1.10.8-0.7-0.41.00.5-0.5-0.50.5-0.6
Locomotion velocity, hab. session 10.60.81.7-1.00.8-0.81.00.8-0.6-1.3-0.81.01.2-1.21.0-0.6-0.61.00.7-0.7-0.70.7-0.8
Time in familiar zone, hab. session 20.91.12.40.7-1.51.5-1.1-1.41.1-0.41.5-0.9-1.51.4-0.21.00.1-1.4-0.40.50.5-0.50.2
Time in novel zone, hab. session 21.71.84.2-0.72.0-2.11.42.0-1.10.8-2.01.22.0-1.90.3-1.5-0.11.90.5-0.5-0.50.5-0.1
Total zone transitions, hab. session 21.72.24.61.8-1.91.9-1.8-1.81.80.41.8-1.3-2.12.2-0.91.21.1-1.6-0.80.80.7-0.70.4
Total locomotion distance, hab. session 20.50.71.91.2-1.41.3-0.8-1.31.3-0.41.3-0.5-0.90.9-0.20.60.7-0.3-0.10.10.00.0-0.7
Locomotion velocity, hab. session 20.60.82.01.3-1.41.4-0.9-1.31.3-0.41.3-0.6-0.90.9-0.30.70.8-0.4-0.20.20.1-0.1-0.6
Novel to familiar place preference ratio0.50.61.3-1.11.1-1.11.01.1-0.7-0.7-1.10.81.0-1.00.6-0.6-0.50.70.4-0.4-0.40.4-0.1
Novelty place preference0.60.71.5-1.01.2-1.21.01.2-0.7-0.6-1.10.81.2-1.20.5-0.7-0.50.90.4-0.4-0.40.4-0.2
Time in novel zone, NPP test0.70.82.0-0.91.3-1.31.01.3-0.7-0.4-1.30.91.4-1.40.6-0.8-0.41.00.4-0.4-0.40.4-0.1
Total zone transitions, NPP test0.30.52.31.5-0.90.9-0.8-0.81.10.30.8-0.5-0.80.8-0.30.40.5-0.4-0.20.20.1-0.1-0.2
Total locomotion distance, NPP test0.40.51.30.10.4-0.50.70.6-0.1-0.6-0.61.00.9-0.90.8-0.8-0.41.10.7-0.7-0.70.7-1.0
Locomotion velocity, NPP test0.10.20.90.1-0.10.10.3-0.00.1-0.80.00.50.3-0.20.5-0.2-0.20.50.4-0.4-0.50.5-1.0
Intraocular pressure0.30.51.50.2-0.91.0-0.7-0.90.6-1.21.0-0.4-1.01.0-0.21.00.7-0.6-0.10.10.0-0.0-0.1
Delta distance traveled before/after self-admin0.50.61.30.6-0.90.9-0.6-0.90.71.00.9-0.9-1.11.1-0.60.60.4-0.8-0.60.60.6-0.6-0.0
Delta ambulatory time before/after self-admin0.30.61.20.3-0.90.9-0.5-1.00.60.81.0-1.0-1.11.1-0.50.80.3-0.8-0.60.60.7-0.7-0.3
Parametrial fat weight0.81.93.2-0.91.7-1.71.71.8-1.2-0.6-1.81.41.7-1.81.2-1.2-1.31.61.2-1.2-1.11.1-0.8
Pavlov. Cond. lever latency1.92.45.52.3-1.81.8-1.9-1.81.91.51.7-1.7-1.51.4-1.61.31.4-1.1-1.21.21.1-1.10.5
Pavlov. Cond. magazine entry latency6.17.810.6-2.72.7-2.83.32.7-3.1-1.9-2.73.22.4-2.43.0-3.1-3.22.72.9-2.9-2.82.8-2.3
Pavlov. Cond. change in total contacts3.63.86.1-2.11.4-1.52.11.4-2.2-2.0-1.42.41.2-1.12.5-2.1-2.11.62.3-2.3-2.32.3-1.9
Pavlov. Cond. index score4.45.67.9-2.72.4-2.42.82.4-2.7-1.8-2.32.72.1-2.12.7-2.4-2.62.12.3-2.3-2.22.2-1.8
Pavlov. Cond. latency score3.44.36.3-2.52.1-2.12.52.1-2.4-1.7-2.02.32.0-1.92.3-2.0-2.21.92.0-2.0-1.91.9-1.5
Pavlov. Cond. lever contacts2.22.75.5-2.31.8-1.81.91.7-2.1-1.7-1.71.81.3-1.21.9-1.5-1.71.11.5-1.5-1.41.4-0.8
Pavlov. Cond. magazine entry number6.88.611.82.6-2.62.7-3.4-2.63.21.72.6-3.3-2.52.5-3.23.43.4-2.9-3.23.23.1-3.12.7
Pavlov. Cond. intertrial magazine entries0.50.61.70.1-1.31.3-0.6-1.30.4-1.11.3-0.3-0.80.80.40.6-0.2-0.70.2-0.2-0.20.2-0.5
Pavlov. Cond. lever-magazine prob. diff.5.16.48.9-2.82.6-2.73.02.6-2.9-1.8-2.62.92.3-2.22.8-2.6-2.62.32.5-2.4-2.42.3-1.7
Pavlov. Cond. response bias8.310.314.1-3.23.3-3.43.83.3-3.6-2.0-3.33.73.0-2.93.3-3.6-3.43.13.2-3.2-3.13.0-2.4
Pavlov. Cond. lever latency0.40.50.70.7-0.80.8-0.8-0.70.80.10.7-0.8-0.90.9-0.70.80.7-0.6-0.80.80.8-0.80.3
Pavlov. Cond. magazine entry latency0.70.91.51.1-0.80.8-1.1-0.91.01.20.8-1.1-0.80.7-1.00.91.1-1.0-0.90.90.9-0.91.0
Pavlov. Cond. change in total contacts0.41.02.6-0.7-0.50.40.4-0.6-1.0-0.90.60.8-0.00.01.3-0.8-1.10.31.5-1.5-1.61.6-1.3
Pavlov. Cond. index score0.00.00.1-0.30.1-0.10.1-0.0-0.30.20.00.20.3-0.30.2-0.2-0.00.00.3-0.3-0.30.30.1
Pavlov. Cond. latency score0.00.10.2-0.40.3-0.30.20.2-0.40.3-0.20.20.4-0.40.2-0.3-0.10.10.3-0.3-0.30.30.2
Pavlov. Cond. lever contacts0.30.40.6-0.60.7-0.70.70.6-0.70.0-0.60.70.8-0.80.6-0.8-0.60.60.7-0.8-0.70.7-0.4
Pavlov. Cond. magazine entry number0.70.93.4-1.10.4-0.40.90.5-1.0-1.8-0.41.10.4-0.31.2-0.8-1.10.71.0-1.0-1.01.0-1.2
Pavlov. Cond. intertrial magazine entries2.24.911.4-3.21.6-1.72.31.7-2.6-3.4-1.62.61.8-1.72.6-1.8-2.31.62.2-2.1-2.12.1-2.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.20.0-0.0-0.0-0.1-0.20.30.10.00.2-0.20.0-0.10.1-0.10.1-0.1-0.20.10.2
Pavlov. Cond. response bias0.10.20.4-0.20.5-0.50.40.4-0.40.5-0.50.40.6-0.60.3-0.5-0.40.40.5-0.5-0.40.4-0.1
Time in closed arm before self-admin0.10.11.01.0-0.30.3-0.3-0.20.70.70.1-0.30.1-0.2-0.40.10.1-0.1-0.10.10.1-0.0-0.3
Time in closed arm after self-admin2.12.45.92.4-0.40.5-1.4-0.22.12.40.1-1.8-0.80.7-1.91.41.5-1.3-1.81.81.9-1.91.7
Time in open arm before self-admin2.63.210.20.8-0.10.2-1.4-0.21.31.90.2-2.0-0.30.4-2.11.92.2-1.5-2.52.52.6-2.63.2
Time in open arm after self-admin0.50.51.5-1.1-0.90.9-0.0-1.2-0.6-1.21.20.2-0.70.70.60.0-0.3-0.60.5-0.5-0.60.5-0.4
Bone: periosteal estimation2.66.314.5-3.83.4-3.33.03.2-2.8-2.6-3.12.62.4-2.32.3-1.8-1.91.81.7-1.7-1.61.5-0.4
Bone: periosteal perimeter1.52.99.9-3.22.6-2.51.92.5-2.0-1.8-2.31.51.7-1.51.1-0.8-0.90.70.6-0.5-0.50.40.9
Bone: post-yield work0.40.72.7-1.60.7-0.60.10.5-0.1-0.7-0.4-0.40.1-0.0-0.21.00.6-0.9-0.90.91.0-1.01.6
Progressive ratio test 1 active lever presses0.40.71.9-1.10.2-0.20.70.1-1.0-1.4-0.11.00.4-0.31.1-0.7-0.90.61.0-1.0-1.11.0-1.0
Progressive ratio test 1 breakpoint0.61.02.6-1.30.3-0.30.90.2-1.1-1.6-0.11.20.5-0.51.3-0.8-1.10.81.2-1.2-1.21.2-1.2
Progressive ratio test 1 inactive lever presses0.82.24.9-2.10.9-0.91.60.8-1.8-2.2-0.81.71.1-1.01.8-1.1-1.61.21.6-1.6-1.61.6-1.6
Progressive ratio test 2 active lever presses0.50.83.5-1.40.1-0.10.70.0-1.0-1.90.10.90.00.01.1-0.3-0.70.41.0-1.0-1.01.0-1.1
Progressive ratio test 2 breakpoint0.60.83.7-1.50.1-0.10.70.0-1.1-1.90.00.9-0.00.11.1-0.4-0.80.31.0-1.0-1.11.0-1.0
Progressive ratio test 2 inactive lever presses0.20.73.8-1.4-0.20.10.6-0.2-0.9-1.90.30.7-0.10.21.1-0.1-0.70.20.8-0.8-0.80.8-1.2
Incentive Sensitization - Responses0.20.63.6-1.50.3-0.30.50.2-1.2-1.9-0.20.80.00.00.8-0.2-0.40.20.7-0.7-0.80.7-0.5
Incentive Sensitization - Breakpoint0.30.63.6-1.50.3-0.20.50.2-1.2-1.9-0.10.7-0.10.20.8-0.2-0.40.10.7-0.7-0.80.8-0.5
Sum of active levers in priming session hrs 5-60.70.72.80.2-1.21.1-0.7-1.3-0.00.11.2-0.1-1.61.7-0.1-0.3-0.1-0.70.3-0.3-0.40.4-0.2
Progressive ratio0.10.20.9-0.4-0.00.00.2-0.1-0.6-0.90.00.4-0.20.10.7-0.5-0.7-0.00.7-0.7-0.60.6-0.5
Food seeking constrained by brief footshock0.40.51.1-0.7-1.01.0-0.2-1.0-0.3-0.81.10.1-0.70.70.9-0.1-0.8-0.90.6-0.6-0.50.5-0.2
Seeking ratio, punishment vs. effort0.00.10.2-0.4-0.40.4-0.1-0.4-0.0-0.00.5-0.0-0.10.10.20.2-0.1-0.40.1-0.1-0.10.10.1
Retroperitoneal fat weight0.10.51.6-0.4-0.10.00.50.0-0.1-0.9-0.00.31.0-1.10.90.0-0.41.10.7-0.7-0.80.8-1.3
Reaction time number correct0.00.20.4-0.30.0-0.0-0.20.10.2-0.3-0.1-0.30.5-0.6-0.30.60.60.1-0.50.50.5-0.50.5
Reaction time mean minus median0.00.20.6-0.4-0.0-0.00.3-0.0-0.3-0.70.00.4-0.30.30.6-0.2-0.40.00.6-0.6-0.60.6-0.8
Reaction time mean minus median AUC0.00.30.7-0.00.4-0.40.50.4-0.50.0-0.50.70.2-0.20.5-0.8-0.60.60.8-0.8-0.80.8-0.9
Reaction time num false alarms0.30.51.9-1.40.8-0.80.70.8-0.9-1.1-0.80.60.9-0.90.8-0.1-0.20.40.3-0.3-0.20.20.1
Reaction time num false alarms AUC0.30.82.8-1.71.0-1.01.01.0-1.1-1.2-0.90.81.2-1.20.9-0.3-0.40.60.5-0.5-0.40.4-0.1
Reaction time trials correct on left0.00.20.4-0.30.0-0.0-0.20.10.2-0.3-0.1-0.30.5-0.6-0.30.60.60.1-0.50.50.5-0.50.5
Reaction time trials on left0.00.10.4-0.40.2-0.1-0.10.20.0-0.3-0.2-0.20.6-0.7-0.20.50.50.2-0.40.40.4-0.40.4
Reaction time mean0.30.61.8-0.30.1-0.20.70.1-0.7-0.1-0.10.8-0.20.20.9-0.8-0.80.41.2-1.2-1.31.3-1.3
Reaction time mean AUC0.20.51.5-0.1-0.0-0.10.5-0.0-0.60.20.00.6-0.30.30.8-0.7-0.70.31.1-1.1-1.11.2-1.2
Median of all reaction times0.40.61.6-0.40.2-0.30.70.2-0.8-0.0-0.20.80.0-0.00.9-0.9-0.80.51.2-1.2-1.31.3-1.3
Reaction time omissions3.35.47.9-2.32.2-2.32.52.2-2.8-1.2-2.22.72.1-2.02.3-2.8-2.42.32.5-2.5-2.52.5-1.8
Reaction time false alarm rate0.40.61.7-1.30.9-0.80.90.9-1.1-0.8-0.80.80.7-0.60.9-0.6-0.70.40.6-0.6-0.50.5-0.2
Reaction time premature initiation rate0.40.71.1-1.00.9-0.91.00.9-0.9-1.0-0.90.80.9-0.91.0-0.6-0.90.50.7-0.7-0.60.6-0.4
Reaction time premature initiations0.30.81.8-1.30.9-0.91.00.9-0.9-1.3-0.80.91.2-1.21.1-0.4-0.90.70.7-0.7-0.60.6-0.4
Std. dev. reaction times0.20.72.5-0.20.2-0.30.80.2-0.7-0.3-0.21.0-0.10.11.0-0.9-0.90.71.3-1.3-1.41.4-1.6
Reaction time trials completed0.00.10.4-0.40.2-0.1-0.10.20.0-0.3-0.2-0.20.6-0.7-0.20.50.50.2-0.40.40.4-0.40.4
Reaction time trials AUC0.00.10.4-0.30.0-0.0-0.20.10.1-0.4-0.1-0.20.6-0.6-0.20.60.50.2-0.40.40.4-0.40.4
Run reversals in cocaine runway, females1.21.33.3-0.0-0.10.1-0.9-0.00.60.30.1-1.10.3-0.2-1.51.61.8-0.9-1.71.71.7-1.71.8
Run reversals in cocaine runway, males0.50.51.6-1.01.3-1.20.61.2-0.8-0.5-1.20.30.7-0.6-0.20.1-0.20.2-0.20.30.3-0.40.7
Latency to leave start box in cocaine runway0.20.30.60.5-0.10.2-0.4-0.10.80.70.1-0.6-0.30.3-0.60.80.6-0.5-0.70.70.8-0.80.5
Latency to leave start box in cocaine runway, F1.72.14.30.9-0.20.3-1.1-0.21.61.50.2-1.5-0.80.9-1.61.61.7-1.4-2.02.02.0-2.02.1
Latency to leave start box in cocaine runway, M1.11.03.0-0.40.2-0.20.80.2-1.0-0.6-0.30.90.5-0.61.2-0.9-1.31.11.5-1.5-1.51.5-1.7
Std. dev. time between licks in bursts0.40.81.50.3-1.21.2-0.9-1.21.0-0.11.2-1.1-0.90.9-0.41.20.8-1.0-0.60.60.6-0.60.4
Total sessions with >9 infusions0.60.71.90.4-1.31.3-1.0-1.30.8-0.61.4-0.6-0.80.8-0.31.00.8-0.8-0.50.50.4-0.40.2
Short access day 1 total inactive lever presses0.20.41.3-1.20.8-0.80.60.8-0.9-1.1-0.80.60.7-0.70.7-0.2-0.20.40.3-0.3-0.30.3-0.0
Short access day 10 total inactive lever presses0.11.02.8-1.70.9-0.91.20.9-1.1-1.6-0.80.91.1-1.11.2-0.3-0.60.80.7-0.7-0.70.7-0.9
Short access day 1 total infusions0.10.20.6-0.0-0.10.10.2-0.1-0.2-0.60.10.60.2-0.20.8-0.5-0.60.30.7-0.7-0.70.7-0.7
Short access day 10 total infusions0.10.21.3-0.7-0.50.40.1-0.5-0.2-1.10.50.3-0.30.30.60.1-0.2-0.20.3-0.3-0.40.4-0.4
Short access total infusions0.20.31.4-0.4-0.30.20.2-0.3-0.2-1.20.30.60.2-0.10.7-0.2-0.40.30.5-0.5-0.60.6-0.8
Short access day 1 locomotion0.20.31.2-1.00.4-0.40.40.4-0.8-1.1-0.40.60.5-0.40.7-0.2-0.40.30.4-0.4-0.40.4-0.0
Short access day 10 total locomotion0.31.06.1-2.5-0.00.00.8-0.1-1.4-2.50.20.7-0.20.31.3-0.0-0.9-0.40.8-0.8-0.70.7-0.6
Short access total locomotion0.30.54.0-2.0-0.20.20.3-0.3-0.8-2.00.40.3-0.10.20.80.4-0.2-0.40.1-0.1-0.10.10.0
One hour access (0.3 mA shock)0.10.10.5-0.70.1-0.0-0.30.0-0.1-0.30.0-0.20.1-0.1-0.30.40.2-0.3-0.50.50.5-0.50.7
Compulsive drug intake0.30.51.40.10.6-0.6-0.20.60.41.0-0.7-0.41.2-1.2-0.60.30.50.2-0.60.60.7-0.71.0
One hour access (shock baseline)0.10.31.9-0.7-0.70.7-0.4-0.8-0.2-1.40.8-0.0-0.80.80.20.4-0.0-0.7-0.10.10.1-0.1-0.1
Social response proportion1.11.53.9-0.1-1.01.0-1.1-1.01.0-0.71.1-1.3-0.50.5-1.02.01.7-1.2-1.51.51.5-1.51.2
Social responses0.10.10.3-0.60.2-0.10.10.1-0.2-0.5-0.1-0.00.4-0.40.30.2-0.1-0.1-0.20.20.3-0.30.3
Social time0.40.61.4-1.0-0.30.3-0.5-0.4-0.1-1.10.5-0.5-0.50.5-0.51.20.9-0.9-0.90.90.8-0.91.0
Soleus weight0.51.42.90.1-0.50.6-1.1-0.61.00.10.6-1.2-1.11.1-1.31.61.6-1.6-1.51.51.4-1.51.7
Bone: stiffness0.10.10.5-0.20.7-0.70.50.7-0.1-0.4-0.70.30.2-0.20.2-0.2-0.30.00.1-0.1-0.00.00.1
Tibialis anterior weight0.72.55.50.5-2.22.2-1.7-2.31.7-0.82.3-1.8-1.61.6-0.82.21.3-1.8-1.11.11.0-1.00.5
Time to tail flick, vehicle, before self-admin0.50.61.70.80.9-0.90.21.10.21.1-1.10.51.3-1.3-0.3-0.90.21.3-0.00.0-0.00.0-0.2
Time to tail flick, vehicle, after self-admin0.71.53.6-0.90.6-0.71.20.7-0.8-1.9-0.71.41.1-1.11.5-0.9-1.21.21.5-1.4-1.51.5-1.8
Time to tail flick, test, before self-admin1.31.53.01.4-1.71.7-1.6-1.71.40.71.7-1.1-1.21.2-0.91.01.2-1.3-0.90.90.8-0.80.5
Time to tail flick, test, after self-admin0.10.10.60.2-0.50.4-0.1-0.40.0-0.70.40.2-0.20.30.3-0.1-0.1-0.10.4-0.4-0.50.5-0.8
Delta time to tail flick, vehicle, before/after SA1.71.87.0-1.80.3-0.31.30.2-1.3-2.6-0.21.40.6-0.61.9-0.7-1.50.61.6-1.6-1.61.6-1.6
Delta time to tail flick, test, before/after SA1.11.32.4-1.20.7-0.71.20.6-1.3-1.6-0.61.30.8-0.81.3-1.2-1.31.11.3-1.3-1.31.3-1.3
Tibia length0.41.02.40.60.9-0.8-0.11.10.90.6-1.1-0.70.7-0.8-0.90.80.8-0.3-1.41.41.6-1.61.4
Ambulatory time before self-admin0.10.40.9-0.61.0-0.90.60.9-0.8-0.1-0.90.60.5-0.50.5-0.9-0.50.10.6-0.6-0.60.60.6
Ambulatory time after self-admin0.00.00.4-0.20.3-0.20.20.2-0.10.6-0.2-0.2-0.10.1-0.1-0.2-0.1-0.3-0.00.00.1-0.10.3
Bone: tissue strength0.40.41.21.1-0.20.2-0.3-0.11.11.00.1-0.7-0.60.5-0.40.60.3-0.7-0.60.60.7-0.70.3
Total heroin consumption0.91.12.3-1.30.6-0.70.80.5-1.5-1.1-0.51.20.2-0.11.1-1.3-1.40.61.4-1.4-1.41.4-0.5
Bone: trabecular number3.77.013.5-2.43.1-3.23.23.1-2.5-1.1-3.12.73.6-3.72.2-2.5-2.13.32.0-2.0-1.91.8-1.5
Bone: trabecular spacing1.92.75.91.3-2.22.3-1.9-2.21.40.12.2-1.5-2.42.4-1.01.50.8-2.3-1.01.00.9-0.90.6
Bone: trabecular thickness1.31.84.1-1.52.0-2.01.62.0-1.0-0.8-2.01.22.0-1.90.7-0.7-0.31.40.4-0.4-0.40.3-0.1
Bone: trabecular tissue density0.10.30.90.30.8-0.80.50.9-0.30.7-1.00.40.5-0.5-0.2-0.5-0.00.50.0-0.0-0.00.0-0.2
Water consumed over 24 hours0.20.30.70.60.3-0.2-0.30.40.60.3-0.4-0.40.2-0.2-0.80.40.6-0.1-0.80.80.9-0.90.8
Number of responses in last shaping day0.50.72.1-1.41.1-1.11.01.1-0.9-1.1-1.10.80.8-0.71.0-0.2-0.60.40.3-0.3-0.20.20.2