Hub : Genes

Wipf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Wipf2	0.02	0.01	9.4e-03	0	-0	-0	0	2.1e-01	5.6e-01	8.2e-01	3.3e-01
2	Adipose	gene expression	Wipf2	0.03	0.02	7.7e-04	0.01	0.02	0.02	0.01	1.1e-02	4.2e-03	5.6e-03	1.1e-02
3	Brain	alternative polyA	NM_001191825.1	0.06	0.04	6.8e-06	0.07	0.06	0.05	0.06	7.5e-07	3.7e-06	2.1e-05	1.8e-06
4	Brain	alternative polyA	XM_063269425.1	0.06	0.04	9.8e-06	0.07	0.06	0.05	0.06	3.3e-07	6.7e-06	3.0e-05	1.8e-06
5	Brain	isoform ratio	NM_001191825.1	0.03	0.02	3.7e-03	0.02	0.01	0.01	0.02	2.6e-03	3.4e-02	2.9e-02	7.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.6	4.5	4.7	-1.9	-2.1	2.2	-2.2	2.2
Area under the delay curve	0.5	0.6	1.5	-1.2	-0.8	0.6	-0.6	0.6
BMI with tail	2.4	8.2	8.9	2.5	3.0	-3.0	3.0	-2.9
BMI without tail	1.3	3.9	4.9	2.2	2.0	-1.9	1.9	-1.8
Body weight	6.8	29.6	34.9	5.9	5.3	-5.3	5.3	-5.3
Weight adjusted by age	0.1	0.2	0.2	0.3	0.1	-0.5	0.5	-0.5
Bone surface	0.0	0.1	0.1	0.0	-0.2	0.3	-0.3	0.3
Bone volume	0.2	0.3	0.5	-0.4	-0.5	0.7	-0.7	0.7
Breakpoint value in progressive ratio session	0.4	0.5	2.3	1.5	0.0	0.0	-0.0	0.0
Number of licking bursts	0.1	0.2	0.5	-0.7	-0.2	0.4	-0.4	0.4
Context. condit. distance diff. score	1.3	1.6	2.0	0.9	1.1	-1.4	1.4	-1.4
Locomotion velocity, session 1	0.5	0.5	0.6	0.8	0.7	-0.7	0.7	-0.7
Locomotion distance, session 1	2.4	3.0	4.9	2.2	1.7	-1.6	1.6	-1.5
Locomotion velocity, session 2	0.2	0.3	0.6	0.8	0.3	-0.5	0.5	-0.5
Locomotion distance, session 2	0.2	0.3	1.3	1.1	0.3	-0.1	0.1	-0.1
Locomotion velocity, session 3	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1	-0.1
Locomotion distance, session 3	0.3	0.4	0.6	0.8	0.5	-0.6	0.6	-0.5
Stereotopy head waving bouts, day 3	2.5	2.9	3.9	-2.0	-1.9	1.6	-1.6	1.5
Stereotopy head waving duration, day 3	0.2	0.3	0.6	-0.8	-0.5	0.4	-0.4	0.4
Locomotion velocity, session 7	1.3	1.4	1.7	0.9	1.2	-1.3	1.3	-1.2
Locomotion distance, session 7	0.5	0.6	0.9	0.5	1.0	-0.8	0.8	-0.7
Stereotopy head waving bouts, day 7	0.8	0.9	2.3	-1.5	-1.1	0.6	-0.6	0.6
Stereotopy head waving duration, day 7	0.3	0.3	0.7	-0.8	-0.8	0.3	-0.3	0.3
Locomotion velocity, session 8	7.6	9.2	9.6	3.1	3.1	-3.0	3.0	-3.0
Locomotion distance, session 8	1.4	2.0	3.0	1.7	1.4	-1.3	1.3	-1.3
Degree of sensitization distance	0.9	0.9	1.5	0.6	1.2	-1.0	1.0	-1.0
Degree of sensitization stereotypy	0.9	1.0	2.8	-1.7	-1.0	0.6	-0.6	0.6
Conditioned locomotion	0.2	0.2	0.4	-0.3	-0.7	0.4	-0.4	0.4
Cocaine response after cond. corrected	1.0	1.2	3.0	-1.7	-0.9	0.9	-0.9	0.9
Cocaine response after cond. not corrected	1.3	1.5	3.7	-1.9	-0.9	1.0	-1.0	1.0
Cocaine response before conditioning	0.1	0.1	0.3	-0.5	-0.1	0.2	-0.2	0.3
Saline control response	0.4	0.6	0.8	0.0	0.8	-0.8	0.8	-0.9
Bone: connectivity density	3.7	5.8	6.0	-2.2	-2.5	2.5	-2.5	2.4
Bone: cortical apparent density	5.6	7.7	8.2	-2.9	-2.7	2.8	-2.8	2.8
Bone: cortical area	0.1	0.1	0.3	-0.6	-0.4	0.2	-0.2	0.2
Bone: cortical porosity	0.5	0.6	1.3	-1.1	-0.7	0.6	-0.6	0.6
Bone: cortical porosity	0.3	0.3	1.2	-1.1	-0.3	0.2	-0.2	0.2
Bone: cortical thickness	1.2	1.9	3.4	-1.8	-1.5	1.1	-1.1	1.2
Bone: cortical thickness	5.0	5.9	7.6	-2.3	-2.8	2.4	-2.4	2.4
Bone: cortical tissue density	5.7	7.7	8.1	-2.9	-2.7	2.8	-2.8	2.8
Condit. Reinf. active minus inactive responses	1.0	1.1	1.5	-0.9	-1.2	1.1	-1.1	1.1
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.8	-1.0	-1.3	1.1	-1.1	1.1
Condit. Reinf. active responses	1.0	1.2	1.4	-1.1	-1.2	1.1	-1.1	1.1
Condit. Reinf. inactive responses	0.1	0.2	0.6	-0.8	-0.2	0.3	-0.3	0.3
Incentive salience index mean	2.0	2.4	2.6	-1.5	-1.6	1.5	-1.5	1.6
Condit. Reinf. lever presses	1.3	1.8	2.1	-1.5	-1.3	1.3	-1.3	1.3
Condit. Reinf. active minus inactive responses	1.0	1.3	1.5	-0.8	-1.1	1.2	-1.2	1.2
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.2	-0.8	-0.9	1.1	-1.1	1.0
Condit. Reinf. active responses	1.5	2.1	2.4	-1.0	-1.4	1.6	-1.6	1.5
Condit. Reinf. inactive responses	1.4	1.9	2.0	-1.2	-1.4	1.4	-1.4	1.4
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.4	0.3
Condit. Reinf. lever reinforcers received	1.6	2.2	2.6	-1.0	-1.6	1.6	-1.6	1.6
Conditioned reinforcement - actives	0.1	0.1	0.6	-0.7	-0.1	0.1	-0.1	0.1
Conditioned reinforcement - inactives	0.2	0.4	0.6	-0.1	-0.2	0.8	-0.8	0.8
Conditioned locomotion	0.6	0.8	2.1	-1.5	-0.7	0.7	-0.7	0.7
Patch foraging indifference point 0 sec	1.7	3.1	3.5	-1.5	-1.6	1.9	-1.9	1.9
Patch foraging indifference point AUC	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1
Delay disc. indifference point, 0s delay	1.9	2.1	2.1	-1.5	-1.5	1.4	-1.4	1.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	-0.9	-0.8	0.3	-0.3	0.3
Delay disc. indifference point, 2s delay	1.3	1.5	3.1	-1.8	-1.0	1.0	-1.0	1.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	0.3	-0.4	0.4	-0.4
Delay disc. indifference point, 4s delay	1.3	1.3	1.7	-1.2	-1.3	1.1	-1.1	1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.9	-0.9	-0.3	0.2	-0.2	0.2
Indifference point function ln k	0.0	0.1	0.1	-0.3	-0.0	-0.3	0.3	-0.3
Indifference point function log k	0.0	0.1	0.1	-0.3	-0.0	-0.3	0.3	-0.3
Patch foraging total patch changes 0 sec	1.0	1.9	2.3	-1.2	-1.2	1.5	-1.5	1.5
Patch foraging total patch changes 12 sec	5.3	6.9	7.6	-2.4	-2.5	2.7	-2.7	2.7
Patch foraging total patch changes 18 sec	0.3	0.4	0.5	-0.4	-0.5	0.7	-0.7	0.7
Patch foraging total patch changes 24 sec	1.2	2.0	2.9	-1.7	-1.2	1.4	-1.4	1.4
Patch foraging total patch changes 6 sec	1.7	2.5	3.0	-1.3	-1.5	1.7	-1.7	1.7
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.1	-0.3	0.3	-0.3	0.4
Patch foraging water rate 0 sec	0.1	0.1	0.2	-0.0	-0.3	0.4	-0.4	0.4
Patch foraging water rate 12 sec	0.1	0.1	0.5	0.7	0.1	-0.3	0.3	-0.3
Patch foraging water rate 18 sec	0.5	0.8	1.0	-1.0	-1.0	0.9	-0.9	0.9
Patch foraging water rate 24 sec	0.4	0.5	0.7	-0.5	-0.8	0.8	-0.8	0.8
Patch foraging water rate 6 sec	1.4	2.1	3.0	-1.0	-1.7	1.5	-1.5	1.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.5	-0.1	0.1	-0.1	0.1
Distance traveled before self-admin	0.1	0.2	0.5	0.7	-0.4	0.3	-0.3	0.3
Distance traveled after self-admin	0.5	0.6	1.3	1.2	0.7	-0.6	0.6	-0.6
Extensor digitorum longus weight	10.0	39.4	41.2	5.8	6.4	-6.4	6.4	-6.4
Bone: elastic displacement	0.0	0.0	0.1	-0.3	0.3	-0.0	0.0	-0.0
Bone: elastic work	0.1	0.1	0.1	-0.3	-0.4	0.3	-0.3	0.3
Bone: endosteal estimation	2.2	4.8	5.8	2.4	2.3	-2.1	2.1	-2.1
Bone: endosteal perimeter	1.5	3.3	4.9	2.2	1.9	-1.6	1.6	-1.7
Epididymis fat weight	0.1	0.4	0.5	0.6	0.6	-0.7	0.7	-0.7
Delta time in closed arm before/after self-admin	4.4	4.1	4.5	2.1	2.0	-2.0	2.0	-2.0
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.1	-0.0	0.0	-0.0	0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.6	-0.2	0.2	-0.2	0.2
Delay discount exponential model param	0.3	0.4	1.0	1.0	0.6	-0.4	0.4	-0.4
Extinction: sum of active levers before priming	1.4	1.6	1.9	0.8	1.3	-1.4	1.4	-1.4
Active lever presses in extinction session 6	0.3	0.3	0.8	-0.2	-0.9	0.5	-0.5	0.5
Bone: final force	0.5	0.7	1.6	-1.2	-0.9	0.7	-0.7	0.6
Bone: final moment	0.3	0.5	1.3	-1.1	-0.7	0.5	-0.5	0.5
Food consumed during 24 hour testing period	0.6	0.8	1.1	0.9	1.0	-0.9	0.9	-0.9
Glucose	0.1	0.2	0.7	-0.9	0.0	-0.1	0.1	-0.1
Heart weight	3.3	5.0	5.8	2.4	2.4	-2.2	2.2	-2.1
Delay discount hyperbolic model param	0.3	0.3	1.0	1.0	0.6	-0.4	0.4	-0.4
Intermittent access intake day 1-15 change	0.1	0.3	0.4	0.7	-0.5	0.5	-0.5	0.5
Intermittent access intake escalation	0.1	0.3	0.4	0.7	-0.4	0.5	-0.5	0.5
Intermittent access intake escalation 2	0.2	0.2	0.9	1.0	0.4	-0.1	0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.7	2.6	3.3	-0.4	-1.8	1.8	-1.8	1.8
Intermitt. access day 15 inactive lever presses	1.2	2.4	2.8	-1.1	-1.5	1.7	-1.7	1.7
Intermitt. access escalation Index	1.4	2.0	2.6	0.9	1.2	-1.6	1.6	-1.6
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.0	0.3	-0.3	0.3
Intermittent access day 15 total infusions	0.1	0.2	0.3	0.6	-0.3	0.4	-0.4	0.3
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.5	0.2	-0.5	0.7	-0.7	0.7
Intermittent access total infusions	0.1	0.1	0.2	0.5	-0.2	0.4	-0.4	0.4
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.5	0.0	0.2	-0.2	0.1
Intermittent access day 15 total locomotion	0.2	0.4	0.7	-0.9	-0.3	0.6	-0.6	0.6
Intermittent access total locomotion	0.9	1.0	1.4	-1.2	-0.8	1.0	-1.0	1.0
Intermittent access standard deviation	1.2	2.5	3.5	-0.0	-1.5	1.9	-1.9	1.8
Left kidney weight	0.6	2.7	5.8	2.4	1.0	-1.5	1.5	-1.5
Right kidney weight	0.0	0.2	0.8	0.9	-0.1	-0.1	0.1	-0.1
Cocaine induced anxiety	2.7	3.9	4.9	2.2	1.7	-2.0	2.0	-1.9
Post-drug Anxiety	0.9	0.9	1.3	1.1	0.8	-1.0	1.0	-0.9
Baseline Anxiety	1.9	2.2	4.4	-2.1	-1.2	1.3	-1.3	1.3
Tail length	0.6	2.5	6.1	2.5	1.2	-1.3	1.3	-1.3
Length with tail	2.7	11.8	22.4	4.7	3.0	-3.0	3.0	-3.1
Length without tail	3.1	9.9	11.1	3.3	3.1	-3.1	3.1	-3.1
Times rat made contact with spout	0.9	1.1	1.7	-1.3	-0.7	1.0	-1.0	1.0
Lifetime Intake	0.3	0.3	0.5	0.4	-0.5	0.7	-0.7	0.6
Liver weight, left	0.3	0.6	0.8	0.4	0.7	-0.9	0.9	-0.7
Liver weight, right	0.3	0.5	1.0	-0.8	-1.0	0.5	-0.5	0.6
Locomotor activity	0.7	1.0	1.3	-1.1	-0.9	1.0	-1.0	1.0
Locomotor testing distance	2.2	4.0	5.1	-2.3	-1.9	1.9	-1.9	1.9
Locomotor testing rearing	4.4	8.8	10.6	-2.9	-3.2	2.9	-2.9	2.9
Locomotion in novel chamber	4.8	6.2	7.0	-2.6	-2.5	2.4	-2.4	2.4
Locomotion in novel chamber post-restriction	0.3	0.5	0.7	-0.4	-0.6	0.8	-0.8	0.8
Fecal boli incidents, locomotor time 1	0.2	0.4	0.6	0.3	0.8	-0.6	0.6	-0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	-0.6	-0.3	0.3	-0.3	0.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.9	-1.0	-0.4	0.2	-0.2	0.2
Bouts of movement, locomotor time 1	0.5	0.6	0.8	0.9	0.6	-0.7	0.7	-0.7
Total resting periods, locomotor time 1	1.0	1.1	1.1	1.0	1.0	-1.1	1.1	-1.1
Rest time, locomotor task time 1	0.0	0.0	0.0	0.1	0.2	0.0	-0.0	0.0
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	-0.2	0.1	-0.1	0.0
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.3	0.5	-0.3	0.3	-0.3
Time >=10cm from walls, locomotor time 2	0.8	1.1	2.6	-1.6	-1.0	0.8	-0.8	0.8
Bouts of movement, locomotor time 2	0.1	0.2	0.7	-0.2	-0.8	0.2	-0.2	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.1	-0.6	0.1	-0.1	0.1
Rest time, locomotor task time 2	0.8	1.1	1.5	1.2	0.9	-1.0	1.0	-1.0
Distance moved, locomotor task time 2	0.1	0.2	0.2	-0.2	0.3	-0.5	0.5	-0.4
Vertical activity count, locomotor time 2	0.2	0.3	0.5	0.2	0.7	-0.6	0.6	-0.6
Light reinforcement 1	2.2	5.3	6.2	-1.6	-2.3	2.5	-2.5	2.5
Light reinforcement 2	0.5	0.8	0.9	-0.8	-0.8	0.9	-0.9	1.0
Bone: marrow area	2.1	4.6	5.6	2.4	2.2	-2.0	2.0	-2.1
Bone: maximum diameter	0.0	0.0	0.0	0.1	-0.2	0.2	-0.2	0.2
Bone: maximum force	0.1	0.1	0.2	0.1	0.2	-0.4	0.4	-0.4
Bone: maximum moment	0.1	0.2	0.4	0.2	0.3	-0.6	0.6	-0.6
Mean time between licks in bursts	1.0	2.5	3.2	1.7	1.8	-1.4	1.4	-1.4
Mean num. licks in bursts	0.1	0.1	0.1	-0.2	-0.3	0.4	-0.4	0.4
Cd content in liver	1.5	1.7	2.3	1.5	1.5	-1.1	1.1	-1.2
Co content in liver	1.8	2.1	2.7	1.6	1.6	-1.3	1.3	-1.4
Cu content in liver	0.2	0.3	1.2	1.1	-0.3	0.1	-0.1	0.1
Fe content in liver	1.6	1.9	2.3	1.5	1.5	-1.3	1.3	-1.3
K content in liver	1.1	1.1	2.2	-0.2	-1.5	1.0	-1.0	1.1
Mg content in liver	0.7	0.7	1.7	-0.4	-1.3	0.7	-0.7	0.8
Mn content in liver	0.9	1.0	2.0	-0.2	-1.4	1.0	-1.0	1.0
Na content in liver	0.4	0.4	0.5	-0.3	-0.7	0.6	-0.6	0.7
Rb content in liver	1.3	1.5	1.8	-1.3	-1.2	1.2	-1.2	1.2
Se content in liver	7.1	8.4	11.2	-2.1	-3.3	3.0	-3.0	2.9
Sr content in liver	0.3	0.3	1.3	1.1	0.1	-0.2	0.2	-0.2
Zn content in liver	3.3	3.7	4.9	-1.2	-2.2	2.0	-2.0	2.0
Bone: minimum diameter	0.6	1.1	1.1	1.1	0.9	-1.0	1.0	-1.1
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.6	-0.3	0.2	-0.2	0.1
Time in novel zone, hab. session 1	0.3	0.3	0.4	-0.5	-0.6	0.5	-0.5	0.6
Total zone transitions, hab. session 1	1.9	2.6	3.2	1.8	1.6	-1.5	1.5	-1.6
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.2	0.0	0.0	-0.0	0.0
Locomotion velocity, hab. session 1	0.1	0.2	0.5	0.7	0.4	-0.2	0.2	-0.2
Time in familiar zone, hab. session 2	0.8	0.8	0.9	-0.7	-0.9	0.9	-0.9	1.0
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	-0.3	0.2	-0.2	0.2
Total zone transitions, hab. session 2	1.0	1.3	1.8	0.9	1.3	-1.2	1.2	-1.1
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.3	0.7	-0.3	0.3	-0.3
Locomotion velocity, hab. session 2	0.3	0.4	0.8	0.6	0.9	-0.5	0.5	-0.5
Novel to familiar place preference ratio	1.4	1.5	1.8	1.2	0.7	-1.3	1.3	-1.3
Novelty place preference	1.2	1.2	1.6	0.9	0.7	-1.3	1.3	-1.3
Time in novel zone, NPP test	0.5	0.5	0.8	0.4	0.3	-0.9	0.9	-0.9
Total zone transitions, NPP test	0.4	0.5	1.3	0.7	1.2	-0.6	0.6	-0.6
Total locomotion distance, NPP test	0.0	0.1	0.1	-0.0	0.4	0.2	-0.2	0.2
Locomotion velocity, NPP test	0.2	0.3	0.9	0.7	0.9	-0.4	0.4	-0.4
Intraocular pressure	3.1	4.4	6.4	1.6	2.5	-2.1	2.1	-2.2
Delta distance traveled before/after self-admin	1.2	1.2	1.4	0.7	1.2	-1.2	1.2	-1.2
Delta ambulatory time before/after self-admin	1.3	1.6	2.0	0.4	1.3	-1.4	1.4	-1.4
Parametrial fat weight	0.5	1.1	1.4	-0.6	-1.0	1.2	-1.2	1.2
Pavlov. Cond. lever latency	2.3	2.9	4.8	2.2	1.5	-1.6	1.6	-1.6
Pavlov. Cond. magazine entry latency	10.7	13.7	16.0	-4.0	-3.6	3.6	-3.6	3.6
Pavlov. Cond. change in total contacts	9.4	10.0	12.0	-3.5	-3.3	3.0	-3.0	3.0
Pavlov. Cond. index score	9.0	11.3	14.8	-3.8	-3.2	3.3	-3.3	3.3
Pavlov. Cond. latency score	6.8	8.6	12.1	-3.5	-2.7	2.8	-2.8	2.8
Pavlov. Cond. lever contacts	3.1	3.7	5.5	-2.3	-1.7	1.8	-1.8	1.8
Pavlov. Cond. magazine entry number	13.4	16.9	22.2	4.7	4.0	-3.9	3.9	-3.9
Pavlov. Cond. intertrial magazine entries	1.5	1.8	1.9	1.3	1.3	-1.4	1.4	-1.3
Pavlov. Cond. lever-magazine prob. diff.	10.7	13.2	16.4	-4.1	-3.4	3.5	-3.5	3.6
Pavlov. Cond. response bias	11.0	13.6	16.9	-4.1	-3.6	3.6	-3.6	3.6
Pavlov. Cond. lever latency	0.6	0.8	0.9	1.0	0.8	-0.9	0.9	-0.9
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	0.2
Pavlov. Cond. change in total contacts	0.5	0.8	0.8	-0.9	-0.8	0.9	-0.9	0.9
Pavlov. Cond. index score	0.2	0.3	0.4	-0.6	-0.3	0.6	-0.6	0.6
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.6	-0.1	0.5	-0.5	0.5
Pavlov. Cond. lever contacts	0.7	0.9	1.2	-1.1	-0.7	1.0	-1.0	1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.5	0.2	-0.5	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	1.3	2.0	2.2	1.4	1.2	-1.5	1.5	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.4	-0.1	0.5	-0.5	0.5
Pavlov. Cond. response bias	1.2	1.7	1.9	-1.2	-1.1	1.4	-1.4	1.4
Time in closed arm before self-admin	1.6	2.0	2.3	-1.4	-1.5	1.4	-1.4	1.4
Time in closed arm after self-admin	0.1	0.1	0.3	0.5	0.1	-0.4	0.4	-0.4
Time in open arm before self-admin	1.2	1.3	1.8	1.3	1.1	-1.1	1.1	-1.1
Time in open arm after self-admin	0.2	0.2	0.5	0.7	0.5	-0.3	0.3	-0.3
Bone: periosteal estimation	0.3	0.6	0.7	0.8	0.8	-0.7	0.7	-0.8
Bone: periosteal perimeter	0.7	1.2	1.5	1.2	1.2	-1.0	1.0	-1.1
Bone: post-yield work	1.5	2.1	2.4	1.2	1.3	-1.6	1.6	-1.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.6	-0.3	0.1	-0.1	0.1
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	-0.5	-0.2	0.0	-0.0	0.0
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.4	0.1	-0.6	0.6	-0.6	0.6
Progressive ratio test 2 active lever presses	0.9	1.0	1.3	-0.6	-1.0	1.2	-1.2	1.2
Progressive ratio test 2 breakpoint	1.0	1.1	1.4	-0.6	-1.0	1.2	-1.2	1.2
Progressive ratio test 2 inactive lever presses	0.2	0.4	0.6	0.1	-0.3	0.7	-0.7	0.7
Incentive Sensitization - Responses	1.4	2.0	2.8	-0.8	-1.1	1.7	-1.7	1.7
Incentive Sensitization - Breakpoint	1.4	1.8	2.5	-0.7	-1.1	1.6	-1.6	1.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.5	-0.4	0.1	-0.1	0.1
Progressive ratio	0.0	0.0	0.2	0.1	-0.4	0.1	-0.1	0.1
Food seeking constrained by brief footshock	0.4	0.4	0.6	-0.6	-0.8	0.6	-0.6	0.6
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	-0.5	0.1	-0.0	0.0	-0.0
Retroperitoneal fat weight	0.1	0.2	0.3	-0.4	-0.4	0.5	-0.5	0.5
Reaction time number correct	0.5	1.0	1.2	0.9	1.1	-1.0	1.0	-1.0
Reaction time mean minus median	0.2	0.4	0.8	0.3	0.9	-0.6	0.6	-0.6
Reaction time mean minus median AUC	0.0	0.1	0.4	-0.6	0.3	-0.1	0.1	-0.1
Reaction time num false alarms	0.7	1.0	1.3	-1.0	-0.6	1.1	-1.1	1.1
Reaction time num false alarms AUC	0.6	0.9	1.2	-0.9	-0.5	1.1	-1.1	1.1
Reaction time trials correct on left	0.5	1.0	1.2	0.9	1.1	-1.0	1.0	-1.0
Reaction time trials on left	0.5	0.9	1.1	0.9	1.1	-1.0	1.0	-1.0
Reaction time mean	0.3	0.4	0.6	-0.2	-0.7	0.7	-0.7	0.8
Reaction time mean AUC	0.3	0.4	0.6	-0.1	-0.7	0.7	-0.7	0.8
Median of all reaction times	1.2	1.6	2.1	-0.6	-1.4	1.4	-1.4	1.4
Reaction time omissions	0.6	0.9	1.2	-0.5	-0.8	1.1	-1.1	1.1
Reaction time false alarm rate	1.3	1.8	2.2	-1.3	-1.0	1.5	-1.5	1.4
Reaction time premature initiation rate	0.5	0.7	1.2	-0.4	-1.1	0.8	-0.8	0.8
Reaction time premature initiations	0.0	0.0	0.1	0.3	-0.2	-0.1	0.1	-0.0
Std. dev. reaction times	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1
Reaction time trials completed	0.5	0.9	1.1	0.9	1.1	-1.0	1.0	-1.0
Reaction time trials AUC	0.5	0.9	1.1	0.7	1.1	-1.0	1.0	-0.9
Run reversals in cocaine runway, females	1.3	1.3	1.6	1.3	1.0	-1.1	1.1	-1.1
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.8	-0.4	0.5	-0.5	0.5
Latency to leave start box in cocaine runway	1.3	1.4	2.5	1.6	1.3	-1.0	1.0	-1.0
Latency to leave start box in cocaine runway, F	1.8	2.0	2.9	1.7	1.5	-1.3	1.3	-1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	-0.2	0.4	-0.4	0.4
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.4	0.3	-0.2	0.2	-0.2
Total sessions with >9 infusions	0.2	0.2	0.3	0.1	-0.5	0.6	-0.6	0.5
Short access day 1 total inactive lever presses	2.1	2.7	3.5	-1.0	-1.5	1.9	-1.9	1.9
Short access day 10 total inactive lever presses	0.1	0.3	0.8	0.9	-0.0	0.5	-0.5	0.5
Short access day 1 total infusions	0.3	0.5	0.8	-0.2	-0.9	0.7	-0.7	0.7
Short access day 10 total infusions	0.5	0.6	0.8	-0.4	-0.7	0.9	-0.9	0.8
Short access total infusions	0.4	0.6	0.8	0.1	-0.8	0.9	-0.9	0.8
Short access day 1 locomotion	1.1	1.4	1.6	-0.9	-1.3	1.3	-1.3	1.2
Short access day 10 total locomotion	1.3	2.4	4.2	-2.1	-1.2	1.5	-1.5	1.4
Short access total locomotion	0.4	0.4	0.6	-0.5	-0.4	0.8	-0.8	0.7
One hour access (0.3 mA shock)	0.2	0.2	0.3	0.3	0.5	-0.5	0.5	-0.5
Compulsive drug intake	0.2	0.3	0.4	-0.3	0.4	-0.6	0.6	-0.6
One hour access (shock baseline)	0.1	0.1	0.3	0.5	-0.1	0.2	-0.2	0.2
Social response proportion	0.3	0.4	0.5	0.1	0.6	-0.7	0.7	-0.7
Social responses	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	-0.1
Social time	0.0	0.1	0.2	0.1	0.4	-0.2	0.2	-0.2
Soleus weight	0.1	0.4	1.6	-1.2	0.3	-0.2	0.2	-0.2
Bone: stiffness	0.0	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2
Tibialis anterior weight	1.6	5.3	6.0	1.8	2.3	-2.4	2.4	-2.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.5	0.3	0.3	-0.3	0.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.0	-0.0
Time to tail flick, test, before self-admin	1.0	1.0	1.3	0.6	1.0	-1.1	1.1	-1.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	0.1	0.4	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.4	-0.6	-0.6	0.4	-0.4	0.4
Delta time to tail flick, test, before/after SA	2.5	2.6	3.0	-1.4	-1.3	1.7	-1.7	1.7
Tibia length	1.5	4.1	4.8	1.4	2.2	-2.1	2.1	-2.2
Ambulatory time before self-admin	0.1	0.2	0.9	0.9	-0.2	0.2	-0.2	0.2
Ambulatory time after self-admin	1.5	1.8	2.8	1.7	1.2	-1.2	1.2	-1.2
Bone: tissue strength	1.6	1.7	2.0	0.7	1.4	-1.4	1.4	-1.4
Total heroin consumption	2.7	3.2	4.0	-1.0	-1.8	2.0	-2.0	2.0
Bone: trabecular number	5.7	9.4	9.7	-2.9	-3.1	3.1	-3.1	3.1
Bone: trabecular spacing	1.8	2.4	3.2	1.1	1.8	-1.6	1.6	-1.6
Bone: trabecular thickness	0.1	0.1	0.1	-0.1	-0.2	0.3	-0.3	0.3
Bone: trabecular tissue density	0.1	0.1	0.2	0.1	0.0	-0.4	0.4	-0.4
Water consumed over 24 hours	0.1	0.1	0.3	0.0	0.6	-0.2	0.2	-0.2
Number of responses in last shaping day	0.3	0.3	0.4	0.2	-0.4	0.6	-0.6	0.6