Hub : Genes

Wipf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_001191825.1 0.02 0.01 8.4e-03 0.01 0.02 0.01 0.01 8.2e-03 2.7e-03 1.1e-02 1.6e-02
2 Adipose gene expression Wipf2 0.03 0.02 6.4e-05 0.03 0.03 0.03 0.03 1.2e-04 5.0e-04 3.3e-04 5.8e-04
3 Brain alternative polyA XM_039086394.1 0.04 0.03 6.2e-04 0.04 0.03 0.08 0.04 3.0e-04 1.6e-03 8.4e-08 9.5e-05
4 Brain isoform ratio NM_001191825.1 0.04 0.03 6.2e-04 0.08 0.03 0.05 0.07 1.2e-07 9.2e-04 2.5e-05 7.2e-07
5 Brain isoform ratio XM_006247353.4 0.05 0.04 4.2e-04 0.06 0.03 0.03 0.04 5.5e-06 9.8e-04 7.2e-04 6.8e-05
6 Brain alternative polyA NM_001191825.1 0.04 0.03 5.0e-04 0.04 0.03 0.07 0.04 3.1e-04 1.4e-03 3.5e-07 1.4e-04
7 BLA isoform ratio XM_006247353.4 0.09 0.07 1.8e-03 0.04 0.01 0.01 0.02 2.8e-03 9.7e-02 5.1e-02 2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density2.23.85.3-2.12.11.6-1.81.8-1.62.3
Area under the delay curve0.30.31.1-0.61.00.2-0.30.3-0.20.5
BMI with tail1.96.18.62.9-2.3-2.62.4-2.42.6-2.0
BMI without tail0.10.10.30.5-0.3-0.10.4-0.40.2-0.6
Body weight4.920.627.94.8-5.3-4.84.3-4.34.8-3.1
Weight adjusted by age0.30.31.10.3-0.4-0.60.1-0.10.51.1
Bone surface0.10.10.8-0.1-0.0-0.20.0-0.00.10.9
Bone volume0.10.21.1-0.40.50.2-0.30.3-0.21.0
Breakpoint value in progressive ratio session0.30.41.5-0.3-1.20.2-0.30.3-0.30.9
Number of licking bursts0.20.20.6-0.20.80.2-0.50.5-0.20.6
Context. condit. distance diff. score1.31.52.51.1-0.8-1.21.6-1.61.2-1.1
Locomotion velocity, session 10.30.40.70.7-0.8-0.60.6-0.60.6-0.2
Locomotion distance, session 12.83.55.01.8-2.2-2.21.7-1.72.2-1.2
Locomotion velocity, session 20.20.20.70.3-0.8-0.40.3-0.30.40.3
Locomotion distance, session 20.40.51.30.4-1.1-1.00.2-0.21.00.0
Locomotion velocity, session 30.10.10.2-0.3-0.4-0.0-0.20.2-0.00.4
Locomotion distance, session 30.30.40.70.4-0.8-0.80.3-0.30.8-0.5
Stereotopy head waving bouts, day 32.83.34.3-1.92.11.9-1.41.4-1.91.9
Stereotopy head waving duration, day 30.30.41.0-0.50.70.6-0.10.1-0.61.0
Locomotion velocity, session 71.01.11.71.2-1.1-1.30.8-0.81.3-0.8
Locomotion distance, session 70.60.81.71.0-0.5-1.00.7-0.71.0-1.3
Stereotopy head waving bouts, day 70.70.81.6-0.91.20.5-0.70.7-0.51.3
Stereotopy head waving duration, day 70.50.61.9-0.80.70.4-0.60.6-0.41.4
Locomotion velocity, session 87.28.69.53.1-2.9-3.03.1-3.13.0-2.3
Locomotion distance, session 81.62.33.41.3-1.5-1.81.5-1.51.8-0.9
Degree of sensitization distance1.21.22.11.3-0.6-0.91.2-1.20.9-1.5
Degree of sensitization stereotypy0.91.02.2-1.01.50.6-0.90.9-0.61.2
Conditioned locomotion0.20.20.4-0.60.30.3-0.40.4-0.30.6
Cocaine response after cond. corrected1.01.13.4-0.81.80.5-0.90.9-0.51.2
Cocaine response after cond. not corrected1.51.64.6-1.02.20.7-1.11.1-0.71.5
Cocaine response before conditioning0.20.20.6-0.30.80.5-0.20.2-0.60.5
Saline control response0.20.20.30.50.5-0.60.4-0.40.50.1
Bone: connectivity density3.35.27.4-2.52.32.0-2.22.2-2.02.7
Bone: cortical apparent density5.77.510.1-2.92.93.2-2.62.6-3.11.4
Bone: cortical area0.10.10.4-0.30.6-0.1-0.20.20.10.4
Bone: cortical porosity0.30.30.8-0.30.90.3-0.50.5-0.30.8
Bone: cortical porosity0.30.31.0-0.21.00.3-0.40.4-0.20.9
Bone: cortical thickness1.11.83.8-1.52.01.0-1.11.1-1.11.5
Bone: cortical thickness6.57.59.7-2.92.42.8-2.52.5-2.83.1
Bone: cortical tissue density5.77.510.3-2.92.93.2-2.62.6-3.21.4
Condit. Reinf. active minus inactive responses0.91.01.5-1.20.80.9-1.11.1-0.80.9
Condit. Reinf. active-inactive response ratio1.11.21.8-1.40.91.0-1.11.1-1.11.0
Condit. Reinf. active responses1.01.21.5-1.21.00.9-1.21.2-0.91.0
Condit. Reinf. inactive responses0.20.30.7-0.30.90.4-0.50.5-0.40.6
Incentive salience index mean1.82.22.8-1.71.41.4-1.71.7-1.31.1
Condit. Reinf. lever presses0.81.11.4-1.11.20.9-1.21.2-0.90.7
Condit. Reinf. active minus inactive responses1.21.52.1-1.10.71.4-1.41.4-1.40.7
Condit. Reinf. active-inactive response ratio0.80.91.3-0.90.51.1-1.11.1-1.10.6
Condit. Reinf. active responses1.82.63.7-1.51.01.7-1.91.9-1.71.2
Condit. Reinf. inactive responses2.02.53.2-1.61.51.5-1.81.8-1.51.4
Condit. Reinf. lever presses0.20.20.3-0.50.20.4-0.60.6-0.40.6
Condit. Reinf. lever reinforcers received1.92.73.8-1.61.01.7-2.02.0-1.71.3
Conditioned reinforcement - actives0.60.61.2-0.81.10.5-0.90.9-0.6-0.5
Conditioned reinforcement - inactives1.31.42.6-1.41.11.6-1.01.0-1.60.1
Conditioned locomotion0.40.51.6-0.61.30.3-0.80.8-0.3-0.6
Patch foraging indifference point 0 sec1.11.83.0-1.71.41.1-1.51.5-1.10.4
Patch foraging indifference point AUC0.10.10.30.1-0.2-0.50.0-0.00.50.4
Delay disc. indifference point, 0s delay0.90.91.3-1.21.10.5-1.11.1-0.61.1
Delay disc. indifference point, 16s delay0.70.72.0-0.80.90.9-0.20.2-0.91.4
Delay disc. indifference point, 2s delay0.91.02.9-1.01.70.5-1.11.1-0.50.4
Delay disc. indifference point, 24s delay0.10.10.20.20.4-0.10.3-0.30.1-0.4
Delay disc. indifference point, 4s delay1.11.22.6-1.21.10.8-0.90.9-0.81.6
Delay disc. indifference point, 8s delay0.20.20.8-0.30.9-0.4-0.10.10.5-0.2
Indifference point function ln k0.00.00.1-0.10.3-0.10.2-0.20.1-0.2
Indifference point function log k0.00.00.1-0.10.3-0.10.2-0.20.1-0.2
Patch foraging total patch changes 0 sec0.71.12.0-1.41.20.8-1.31.3-0.70.1
Patch foraging total patch changes 12 sec4.55.87.2-2.72.42.2-2.72.7-2.12.0
Patch foraging total patch changes 18 sec0.40.50.8-0.80.60.5-0.90.9-0.50.6
Patch foraging total patch changes 24 sec1.41.83.1-1.51.80.7-1.31.3-0.71.6
Patch foraging total patch changes 6 sec1.72.53.3-1.81.51.6-1.71.7-1.51.0
Patch foraging time to switch 0 sec0.10.10.1-0.40.20.3-0.40.4-0.30.1
Patch foraging water rate 0 sec0.10.10.2-0.3-0.10.3-0.40.4-0.30.1
Patch foraging water rate 12 sec0.10.10.40.0-0.6-0.40.2-0.20.40.2
Patch foraging water rate 18 sec0.70.92.8-0.90.90.7-0.70.7-0.71.7
Patch foraging water rate 24 sec0.81.12.2-0.90.61.5-0.80.8-1.40.7
Patch foraging water rate 6 sec1.92.73.3-1.71.01.8-1.71.7-1.81.7
Seeking ratio, delayed vs. immediate footshock0.20.30.7-0.6-0.10.7-0.40.4-0.80.2
Distance traveled before self-admin0.30.30.80.1-0.60.8-0.40.4-0.90.1
Distance traveled after self-admin0.60.71.91.2-1.4-0.20.6-0.60.2-0.6
Extensor digitorum longus weight8.633.940.46.4-5.7-5.76.0-6.05.6-5.3
Bone: elastic displacement0.10.10.80.20.2-0.30.1-0.10.3-0.9
Bone: elastic work0.10.10.6-0.30.20.1-0.20.2-0.20.7
Bone: endosteal estimation2.14.66.32.4-2.5-2.32.0-2.02.2-1.5
Bone: endosteal perimeter1.53.24.91.9-2.2-1.71.6-1.61.7-1.8
Epididymis fat weight0.10.21.20.3-1.1-0.2-0.20.20.2-0.3
Delta time in closed arm before/after self-admin3.53.44.22.0-2.0-1.92.0-2.01.9-0.7
Delta time in open arm before/after self-admin0.10.10.3-0.00.00.50.2-0.2-0.50.1
Diff in mean of infusions in LGA sessions0.20.20.7-0.1-0.8-0.4-0.30.30.30.4
Delay discount exponential model param0.10.20.60.4-0.8-0.10.2-0.20.1-0.4
Extinction: sum of active levers before priming1.71.72.51.4-0.9-1.61.4-1.41.6-0.5
Active lever presses in extinction session 62.01.95.6-1.40.60.4-1.61.6-0.52.4
Bone: final force0.61.02.7-0.81.30.5-0.90.9-0.51.7
Bone: final moment0.40.71.9-0.61.20.3-0.70.7-0.31.4
Food consumed during 24 hour testing period0.81.01.11.0-1.0-0.91.0-1.00.9-1.1
Glucose0.20.31.1-0.21.10.3-0.20.2-0.30.5
Heart weight3.75.26.52.4-2.3-1.92.5-2.51.9-2.2
Delay discount hyperbolic model param0.20.21.00.6-1.0-0.10.3-0.30.1-0.5
Intermittent access intake day 1-15 change0.60.62.0-0.90.10.8-0.50.5-0.81.4
Intermittent access intake escalation0.80.82.4-1.00.20.8-0.60.6-0.81.6
Intermittent access intake escalation 20.10.10.3-0.2-0.30.00.1-0.1-0.00.5
Intermitt. access day 1 inactive lever presses2.83.06.3-1.90.61.7-1.51.5-1.72.5
Intermitt. access day 15 inactive lever presses4.44.86.1-2.51.82.3-2.32.3-2.22.0
Intermitt. access escalation Index1.61.42.11.3-0.7-1.41.4-1.41.30.0
Intermittent access day 1 total infusions0.30.30.6-0.40.40.8-0.50.5-0.8-0.3
Intermittent access day 15 total infusions0.80.91.5-1.10.51.2-0.60.6-1.21.2
Intermittent access terminal intake (last 3 days)0.70.81.3-1.10.51.1-0.70.7-1.10.8
Intermittent access total infusions0.30.40.9-0.60.00.9-0.30.3-0.90.5
Intermittent access day 1 locomotion0.40.40.8-0.30.70.6-0.60.6-0.6-0.9
Intermittent access day 15 total locomotion0.30.41.0-0.30.80.4-0.50.5-0.3-1.0
Intermittent access total locomotion0.70.81.0-0.90.90.9-1.01.0-0.9-0.2
Intermittent access standard deviation2.02.12.9-1.70.31.6-1.41.4-1.61.6
Left kidney weight0.92.46.61.3-2.6-1.41.6-1.61.3-0.1
Right kidney weight0.20.41.50.3-1.2-0.40.4-0.40.40.9
Cocaine induced anxiety1.72.03.01.4-1.6-1.71.3-1.31.7-0.2
Post-drug Anxiety0.20.20.40.3-0.2-0.60.4-0.40.60.6
Baseline Anxiety1.31.43.6-1.11.91.1-1.01.0-1.20.4
Tail length0.20.62.70.5-1.6-0.50.6-0.60.5-0.5
Length with tail2.69.618.72.8-4.3-3.32.9-2.93.2-1.6
Length without tail3.47.412.92.7-3.6-3.12.5-2.53.0-1.1
Times rat made contact with spout0.80.91.8-0.81.31.1-0.90.9-1.00.2
Lifetime Intake0.40.51.0-0.8-0.11.0-0.40.4-1.00.7
Liver weight, left0.10.20.4-0.2-0.30.6-0.40.4-0.60.5
Liver weight, right1.01.75.4-1.30.21.2-0.90.9-1.32.3
Locomotor activity0.71.11.8-0.91.00.7-1.21.2-0.71.3
Locomotor testing distance2.23.75.1-2.02.21.6-2.32.3-1.51.5
Locomotor testing rearing5.99.211.6-3.42.83.1-3.23.2-3.02.4
Locomotion in novel chamber6.27.68.4-2.82.92.8-2.62.6-2.82.8
Locomotion in novel chamber post-restriction0.70.91.5-0.91.00.8-1.21.2-0.80.5
Fecal boli incidents, locomotor time 10.30.31.10.8-0.3-0.20.4-0.40.2-1.0
Change in fecal boli incidents, locomotor task0.20.20.40.00.3-0.70.3-0.30.6-0.3
Time >=10cm from walls, locomotor time 10.20.20.9-0.41.0-0.4-0.20.20.4-0.2
Bouts of movement, locomotor time 10.30.30.80.6-0.9-0.70.2-0.20.60.4
Total resting periods, locomotor time 10.60.61.21.1-1.1-0.90.5-0.50.9-0.2
Rest time, locomotor task time 10.10.10.30.10.00.5-0.20.2-0.5-0.1
Distance moved, locomotor task time 10.10.10.3-0.40.5-0.0-0.00.0-0.00.6
Vertical activity count, locomotor time 10.20.20.40.3-0.1-0.70.5-0.50.6-0.4
Time >=10cm from walls, locomotor time 21.01.02.8-1.11.70.1-1.21.2-0.20.4
Bouts of movement, locomotor time 20.50.51.5-0.70.10.2-0.80.8-0.31.2
Total resting periods, locomotor time 20.40.41.5-0.6-0.20.1-0.60.6-0.21.2
Rest time, locomotor task time 20.70.81.71.0-1.3-0.80.9-0.90.7-0.5
Distance moved, locomotor task time 20.20.20.50.20.3-0.70.5-0.50.7-0.0
Vertical activity count, locomotor time 20.40.50.80.5-0.0-0.60.9-0.90.6-0.7
Light reinforcement 13.15.66.7-2.51.82.6-2.52.5-2.62.1
Light reinforcement 20.50.60.7-0.80.80.8-0.80.8-0.70.8
Bone: marrow area2.04.35.92.3-2.4-2.22.0-2.02.1-1.5
Bone: maximum diameter0.00.00.1-0.2-0.0-0.1-0.30.30.10.3
Bone: maximum force0.10.10.40.20.2-0.50.2-0.20.40.6
Bone: maximum moment0.10.20.40.40.1-0.70.4-0.40.60.4
Mean time between licks in bursts1.52.13.21.6-1.5-1.31.2-1.21.3-1.8
Mean num. licks in bursts0.10.10.4-0.30.20.6-0.10.1-0.5-0.4
Cd content in liver0.10.10.2-0.40.40.3-0.10.1-0.20.5
Co content in liver0.70.81.70.8-1.3-0.51.0-1.00.5-1.0
Cu content in liver0.10.10.9-0.2-1.00.00.1-0.1-0.0-0.1
Fe content in liver0.81.01.51.0-1.2-1.11.0-1.01.1-0.1
K content in liver1.91.94.3-1.60.71.0-1.41.4-1.02.1
Mg content in liver1.41.42.5-1.60.70.9-1.11.1-0.91.6
Mn content in liver2.12.34.2-2.00.91.2-1.61.6-1.21.8
Na content in liver0.70.72.9-0.70.60.5-0.70.7-0.61.7
Rb content in liver1.11.41.9-1.41.31.2-1.21.2-1.10.9
Se content in liver6.27.59.5-3.01.73.1-2.72.7-3.12.7
Sr content in liver0.10.10.2-0.4-0.20.4-0.30.3-0.4-0.2
Zn content in liver2.73.04.2-2.01.22.0-1.81.8-2.01.1
Bone: minimum diameter0.51.01.80.9-1.0-1.30.9-0.91.3-0.4
Time in familiar zone, hab. session 10.50.50.9-0.30.80.8-0.40.4-0.80.9
Time in novel zone, hab. session 10.20.20.5-0.70.70.2-0.40.4-0.1-0.5
Total zone transitions, hab. session 11.92.63.21.6-1.8-1.51.7-1.71.5-1.5
Total locomotion distance, hab. session 10.00.00.1-0.0-0.20.00.4-0.4-0.0-0.0
Locomotion velocity, hab. session 10.20.30.80.4-0.9-0.30.6-0.60.2-0.1
Time in familiar zone, hab. session 20.80.82.0-0.80.61.0-0.60.6-0.91.4
Time in novel zone, hab. session 20.20.20.4-0.30.30.2-0.60.6-0.3-0.4
Total zone transitions, hab. session 21.51.92.61.3-0.9-1.51.3-1.31.6-1.6
Total locomotion distance, hab. session 20.40.60.90.7-0.4-0.70.8-0.80.8-1.0
Locomotion velocity, hab. session 20.70.91.10.9-0.7-1.01.0-1.01.0-1.0
Novel to familiar place preference ratio0.60.61.50.7-1.2-0.80.7-0.70.7-0.2
Novelty place preference0.40.40.90.6-1.0-0.70.6-0.60.6-0.2
Time in novel zone, NPP test0.10.10.20.2-0.4-0.30.2-0.20.30.1
Total zone transitions, NPP test0.91.31.61.2-0.6-1.21.1-1.11.3-1.3
Total locomotion distance, NPP test0.20.30.50.40.1-0.50.5-0.50.6-0.7
Locomotion velocity, NPP test0.71.11.50.9-0.6-1.11.1-1.11.1-1.2
Intraocular pressure2.83.98.52.3-1.5-1.51.9-1.91.5-2.9
Delta distance traveled before/after self-admin1.21.31.61.2-0.9-1.21.2-1.21.2-0.8
Delta ambulatory time before/after self-admin1.01.01.71.1-0.5-1.31.0-1.01.3-0.6
Parametrial fat weight1.93.75.0-1.90.82.0-2.12.1-2.02.2
Pavlov. Cond. lever latency2.73.44.11.7-2.0-1.82.0-2.01.7-1.6
Pavlov. Cond. magazine entry latency10.012.914.5-3.63.83.6-3.63.6-3.63.3
Pavlov. Cond. change in total contacts8.89.410.7-3.33.13.2-3.03.0-3.22.6
Pavlov. Cond. index score7.69.612.1-3.13.53.1-3.23.2-3.02.5
Pavlov. Cond. latency score5.87.49.6-2.63.12.7-2.82.8-2.62.3
Pavlov. Cond. lever contacts2.12.53.5-1.41.91.5-1.81.8-1.51.1
Pavlov. Cond. magazine entry number11.614.417.83.9-4.2-3.93.8-3.83.8-3.1
Pavlov. Cond. intertrial magazine entries1.31.61.81.3-1.3-1.31.3-1.31.3-1.1
Pavlov. Cond. lever-magazine prob. diff.8.410.413.3-3.23.73.2-3.33.3-3.12.6
Pavlov. Cond. response bias8.910.812.8-3.43.63.3-3.33.3-3.22.8
Pavlov. Cond. lever latency0.40.60.80.7-0.7-0.80.9-0.90.8-0.5
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.1-0.10.1-0.10.1-0.2
Pavlov. Cond. change in total contacts0.60.81.2-1.00.81.1-1.01.0-1.10.2
Pavlov. Cond. index score0.20.20.3-0.30.60.5-0.50.5-0.50.1
Pavlov. Cond. latency score0.10.10.2-0.20.50.4-0.40.4-0.4-0.1
Pavlov. Cond. lever contacts0.81.11.5-1.01.21.0-1.21.2-1.00.8
Pavlov. Cond. magazine entry number0.00.00.10.1-0.3-0.20.2-0.20.1-0.2
Pavlov. Cond. intertrial magazine entries1.11.52.21.2-1.5-1.21.1-1.11.1-1.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.20.40.4-0.40.4-0.40.0
Pavlov. Cond. response bias1.21.62.0-1.21.21.3-1.41.4-1.21.1
Time in closed arm before self-admin1.31.42.8-1.11.31.7-0.90.9-1.60.2
Time in closed arm after self-admin0.30.30.70.5-0.6-0.00.8-0.8-0.0-0.0
Time in open arm before self-admin2.02.24.61.3-1.6-2.11.1-1.12.0-0.3
Time in open arm after self-admin0.50.50.90.8-0.9-0.70.6-0.60.7-0.7
Bone: periosteal estimation0.30.60.90.8-0.8-1.00.7-0.70.9-0.2
Bone: periosteal perimeter0.71.21.51.2-1.2-1.21.0-1.01.2-0.9
Bone: post-yield work1.72.33.11.5-1.1-1.81.6-1.61.8-1.1
Progressive ratio test 1 active lever presses0.70.71.6-0.91.30.9-0.60.6-0.90.4
Progressive ratio test 1 breakpoint0.60.61.3-0.81.10.9-0.60.6-0.90.5
Progressive ratio test 1 inactive lever presses1.61.82.7-1.60.81.3-1.21.2-1.41.6
Progressive ratio test 2 active lever presses1.11.21.8-1.21.11.3-1.01.0-1.4-0.0
Progressive ratio test 2 breakpoint0.80.91.4-1.10.91.2-0.90.9-1.2-0.0
Progressive ratio test 2 inactive lever presses0.50.61.1-0.80.41.0-0.80.8-1.0-0.2
Incentive Sensitization - Responses1.11.21.6-1.01.01.3-1.11.1-1.2-0.9
Incentive Sensitization - Breakpoint1.11.11.6-0.91.01.3-1.11.1-1.2-0.8
Sum of active levers in priming session hrs 5-60.60.52.0-0.80.70.3-0.50.5-0.31.4
Progressive ratio0.30.30.9-0.40.00.4-0.70.7-0.40.9
Food seeking constrained by brief footshock0.20.20.5-0.60.40.3-0.50.5-0.20.7
Seeking ratio, punishment vs. effort0.10.20.40.10.5-0.30.4-0.40.3-0.6
Retroperitoneal fat weight0.00.10.50.3-0.70.20.3-0.3-0.20.2
Reaction time number correct0.71.01.41.1-0.9-1.01.2-1.20.9-0.6
Reaction time mean minus median0.50.72.10.8-0.3-0.80.5-0.50.8-1.5
Reaction time mean minus median AUC0.20.20.80.30.6-0.30.1-0.10.4-0.9
Reaction time num false alarms0.40.60.9-0.60.90.7-0.90.9-0.70.8
Reaction time num false alarms AUC0.30.50.8-0.40.80.5-0.90.9-0.50.5
Reaction time trials correct on left0.71.01.41.1-0.9-1.01.2-1.20.9-0.6
Reaction time trials on left0.71.01.41.1-0.9-0.91.2-1.20.8-0.7
Reaction time mean0.20.30.5-0.70.10.7-0.50.5-0.70.2
Reaction time mean AUC0.20.30.5-0.70.00.7-0.40.4-0.70.4
Median of all reaction times1.01.42.2-1.40.61.5-1.11.1-1.41.0
Reaction time omissions1.11.52.0-1.21.11.4-1.31.3-1.40.8
Reaction time false alarm rate0.91.21.8-0.91.20.9-1.31.3-0.90.9
Reaction time premature initiation rate1.01.35.9-1.10.50.7-0.70.7-0.72.4
Reaction time premature initiations0.30.42.7-0.3-0.3-0.10.3-0.30.11.6
Std. dev. reaction times0.00.10.40.20.0-0.1-0.00.00.1-0.6
Reaction time trials completed0.71.01.41.1-0.9-0.91.2-1.20.8-0.7
Reaction time trials AUC0.60.91.31.0-0.8-0.91.1-1.10.8-0.7
Run reversals in cocaine runway, females2.32.23.71.3-1.6-1.41.9-1.91.3-0.6
Run reversals in cocaine runway, males0.40.41.0-0.71.00.6-0.50.5-0.60.5
Latency to leave start box in cocaine runway1.41.52.71.3-1.6-0.91.4-1.40.8-0.8
Latency to leave start box in cocaine runway, F1.01.12.31.2-1.5-0.81.2-1.20.7-0.0
Latency to leave start box in cocaine runway, M0.10.10.2-0.4-0.30.2-0.10.1-0.2-0.5
Std. dev. time between licks in bursts0.10.10.20.3-0.5-0.30.1-0.10.20.1
Total sessions with >9 infusions0.50.51.1-1.00.90.6-0.30.3-0.61.0
Short access day 1 total inactive lever presses1.92.23.5-1.71.11.9-1.31.3-1.80.9
Short access day 10 total inactive lever presses0.30.30.80.1-0.9-0.40.5-0.50.50.7
Short access day 1 total infusions1.21.32.3-1.20.21.5-0.80.8-1.51.4
Short access day 10 total infusions0.40.50.8-0.70.50.9-0.60.6-0.90.4
Short access total infusions0.70.81.6-0.9-0.11.1-0.50.5-1.11.3
Short access day 1 locomotion3.43.64.8-2.21.61.9-2.02.0-1.91.6
Short access day 10 total locomotion1.31.52.8-1.01.71.0-1.41.4-1.0-0.6
Short access total locomotion0.30.30.5-0.70.60.7-0.60.6-0.7-0.0
One hour access (0.3 mA shock)0.10.10.3-0.10.00.3-0.10.1-0.4-0.5
Compulsive drug intake0.70.71.30.7-0.3-0.71.0-1.00.6-1.1
One hour access (shock baseline)0.50.61.0-0.80.31.0-0.80.8-1.00.6
Social response proportion0.40.40.80.6-0.1-0.70.9-0.90.7-0.3
Social responses0.00.00.0-0.10.10.0-0.10.10.10.1
Social time0.20.20.40.5-0.3-0.50.3-0.30.6-0.7
Soleus weight0.10.42.10.41.4-0.40.1-0.10.40.4
Bone: stiffness0.10.21.2-0.10.2-0.0-0.00.0-0.01.1
Tibialis anterior weight1.24.05.52.3-1.9-1.92.2-2.21.9-1.1
Time to tail flick, vehicle, before self-admin0.50.53.20.30.4-0.10.1-0.10.2-1.8
Time to tail flick, vehicle, after self-admin0.10.10.2-0.00.40.0-0.50.50.1-0.4
Time to tail flick, test, before self-admin2.01.92.91.3-0.8-1.71.3-1.31.7-1.5
Time to tail flick, test, after self-admin0.10.20.70.10.30.4-0.20.2-0.2-0.8
Delta time to tail flick, vehicle, before/after SA0.30.30.8-0.40.50.2-0.70.7-0.10.9
Delta time to tail flick, test, before/after SA2.32.13.4-1.21.41.8-1.51.5-1.80.3
Tibia length1.33.85.42.3-1.5-2.12.2-2.22.1-0.9
Ambulatory time before self-admin0.20.20.60.2-0.80.5-0.10.1-0.6-0.6
Ambulatory time after self-admin1.21.33.11.6-1.8-0.51.0-1.00.5-1.0
Bone: tissue strength1.31.31.91.2-0.5-1.21.0-1.01.2-1.4
Total heroin consumption1.61.92.6-1.50.81.4-1.61.6-1.41.1
Bone: trabecular number5.38.310.0-3.03.02.7-2.82.8-2.73.2
Bone: trabecular spacing1.51.92.91.7-1.2-1.31.3-1.31.3-1.5
Bone: trabecular thickness0.10.10.1-0.30.30.3-0.20.2-0.30.2
Bone: trabecular tissue density0.10.10.5-0.1-0.0-0.30.2-0.20.3-0.7
Water consumed over 24 hours0.10.20.40.5-0.1-0.20.5-0.50.2-0.6
Number of responses in last shaping day0.50.50.8-0.9-0.10.8-0.70.7-0.80.8