Wdr95

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Wdr95	0.15	0.09	2.2e-03	0.04	0.04	0.04	0.04	5.9e-03	2.5e-03	3.0e-03	5.5e-03
2	IC	intron excision ratio	chr12_10470100_10471974	0.41	0.2	7.8e-04	0.02	0.03	0.01	0	3.3e-02	1.8e-02	1.8e-01	2.4e-01
3	PL	intron excision ratio	chr12_10470100_10471974	0.07	0.06	1.6e-03	0.03	0.02	0.01	0.02	6.8e-04	5.4e-03	4.1e-02	3.9e-03
4	PL	gene expression	Wdr95	0.04	0.03	4.0e-03	0.03	0.02	0.01	0.02	5.6e-04	1.8e-03	1.4e-02	1.7e-03
5	BLA	mRNA stability	Wdr95	0.11	0.08	1.7e-04	0.05	0.05	0.06	0.06	7.9e-04	1.0e-03	5.9e-04	4.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	5.5	9.4	14.9	-2.9	3.9	3.8	-2.5	-1.7
Area under the delay curve	0.4	0.5	0.8	0.8	-0.8	-0.9	0.0	0.7
BMI with tail	1.9	6.7	10.2	-2.2	3.2	3.1	-1.7	-2.3
BMI without tail	0.8	2.5	6.3	-2.5	0.6	0.3	-2.3	0.8
Body weight	8.4	36.9	56.2	-7.5	6.8	6.3	-6.1	-2.1
Weight adjusted by age	1.7	2.7	4.5	-2.1	1.0	1.6	-1.9	1.2
Bone surface	5.0	9.1	13.0	-3.2	3.6	3.6	-2.9	-1.1
Bone volume	4.7	8.4	14.6	-2.2	3.8	3.8	-1.9	-2.1
Breakpoint value in progressive ratio session	0.2	0.2	0.5	-0.2	-0.5	-0.2	-0.4	0.7
Number of licking bursts	1.0	1.7	4.4	-2.1	0.5	0.7	-1.7	0.6
Context. condit. distance diff. score	1.5	1.8	3.4	-1.0	1.8	1.3	-1.3	-1.1
Locomotion velocity, session 1	0.7	0.8	1.6	-0.3	-1.0	-1.3	-0.5	1.0
Locomotion distance, session 1	0.9	1.1	3.2	-0.0	-1.0	-1.1	-0.3	1.8
Locomotion velocity, session 2	1.1	1.3	2.3	-1.1	-0.8	-0.7	-1.5	1.4
Locomotion distance, session 2	1.7	2.4	6.2	-1.1	-1.0	-1.1	-1.5	2.5
Locomotion velocity, session 3	0.7	0.8	2.2	-0.2	0.9	1.5	0.0	-0.9
Locomotion distance, session 3	0.1	0.1	0.3	-0.1	0.2	0.1	0.3	0.5
Stereotopy head waving bouts, day 3	1.2	1.4	3.0	-1.6	0.3	0.1	-1.7	1.2
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.3	0.2
Locomotion velocity, session 7	0.2	0.2	0.5	0.7	0.1	-0.0	0.6	-0.1
Locomotion distance, session 7	0.1	0.1	0.2	0.5	0.0	0.0	0.4	-0.0
Stereotopy head waving bouts, day 7	1.6	1.7	3.1	0.7	-1.7	-1.5	0.2	1.8
Stereotopy head waving duration, day 7	0.9	1.1	2.1	0.7	-1.5	-1.2	0.2	1.3
Locomotion velocity, session 8	0.6	0.7	1.6	-0.2	-0.6	-1.0	-0.7	1.3
Locomotion distance, session 8	1.4	2.0	5.3	-1.7	1.1	0.5	-2.3	0.6
Degree of sensitization distance	0.3	0.3	0.6	0.5	-0.7	-0.8	-0.0	0.2
Degree of sensitization stereotypy	1.3	1.4	2.3	1.3	-1.5	-1.3	0.8	0.8
Conditioned locomotion	0.1	0.1	0.1	0.1	-0.2	-0.3	-0.0	0.4
Cocaine response after cond. corrected	1.1	1.3	2.7	1.6	-0.5	-0.7	1.5	-0.9
Cocaine response after cond. not corrected	1.4	1.7	3.2	1.8	-0.5	-0.7	1.8	-1.1
Cocaine response before conditioning	0.1	0.1	0.3	-0.1	0.3	0.4	0.3	-0.5
Saline control response	2.7	3.6	6.8	-2.3	-0.3	-0.4	-2.6	2.4
Bone: connectivity density	6.3	9.8	13.5	-3.7	3.5	3.3	-3.5	-0.6
Bone: cortical apparent density	0.3	0.4	0.9	0.6	0.4	0.5	0.6	-0.9
Bone: cortical area	1.5	2.4	4.4	-1.5	2.1	1.8	-1.1	-0.9
Bone: cortical porosity	1.2	1.3	2.0	0.6	-1.4	-1.4	0.5	1.4
Bone: cortical porosity	1.2	1.4	2.1	0.8	-1.4	-1.5	0.6	1.3
Bone: cortical thickness	1.2	1.9	3.5	-1.3	1.9	1.7	-0.8	-0.9
Bone: cortical thickness	0.1	0.1	0.3	-0.1	-0.4	-0.0	0.3	0.5
Bone: cortical tissue density	0.2	0.3	0.7	0.6	0.2	0.4	0.6	-0.8
Condit. Reinf. active minus inactive responses	0.9	1.0	1.9	-0.8	1.4	1.4	-0.4	-0.7
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.6	-0.3	1.2	1.3	0.1	-1.1
Condit. Reinf. active responses	0.1	0.2	0.3	-0.5	0.5	0.5	-0.2	-0.1
Condit. Reinf. inactive responses	0.5	0.6	1.1	0.4	-1.0	-1.0	0.5	0.7
Incentive salience index mean	0.2	0.2	0.5	-0.3	0.7	0.6	0.1	-0.4
Condit. Reinf. lever presses	0.5	0.7	1.7	1.0	-0.6	-0.8	1.3	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.2	-0.9	-0.7	-0.6	-0.6	1.1
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.3	-0.8	-1.1	-0.9	-0.6	1.5
Condit. Reinf. active responses	0.4	0.6	1.6	-1.3	-0.2	0.0	-0.9	0.8
Condit. Reinf. inactive responses	0.3	0.3	0.5	-0.6	0.7	0.7	-0.5	-0.3
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.7	0.9	0.9	-0.1	-0.5
Condit. Reinf. lever reinforcers received	0.4	0.6	1.8	-1.4	-0.0	0.2	-0.9	0.7
Conditioned reinforcement - actives	0.3	0.5	1.4	-1.2	0.0	0.1	-1.0	0.3
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.5	-0.4	-0.4	0.4	-0.2
Conditioned locomotion	0.5	0.7	1.7	-1.0	-0.7	-0.7	-1.3	-0.1
Patch foraging indifference point 0 sec	1.4	2.5	4.9	-1.1	2.2	1.9	-0.6	-1.6
Patch foraging indifference point AUC	0.4	0.5	1.6	-1.2	0.4	0.5	-0.8	0.2
Delay disc. indifference point, 0s delay	0.5	0.6	1.0	-0.4	1.0	0.9	-1.0	-0.0
Delay disc. indifference point, 16s delay	0.2	0.3	0.6	0.8	-0.4	-0.5	0.5	-0.2
Delay disc. indifference point, 2s delay	0.7	0.8	2.5	1.6	-0.8	-0.8	0.2	0.5
Delay disc. indifference point, 24s delay	0.4	0.5	0.8	0.7	-0.8	-0.9	0.6	0.4
Delay disc. indifference point, 4s delay	0.4	0.5	0.9	1.0	-0.7	-0.9	0.3	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.2	-0.4	-0.3	-0.2	0.6
Indifference point function ln k	0.2	0.4	0.7	-0.6	0.6	0.7	-0.9	0.0
Indifference point function log k	0.2	0.4	0.7	-0.6	0.6	0.7	-0.9	0.0
Patch foraging total patch changes 0 sec	1.3	2.4	4.6	-1.0	2.1	1.9	-0.5	-1.5
Patch foraging total patch changes 12 sec	2.0	2.6	4.9	-1.1	2.2	1.9	-0.6	-1.8
Patch foraging total patch changes 18 sec	0.3	0.4	0.9	-0.2	0.7	0.8	0.3	-0.9
Patch foraging total patch changes 24 sec	0.3	0.6	1.0	-0.6	0.7	1.0	0.5	-0.8
Patch foraging total patch changes 6 sec	0.3	0.5	0.9	-0.6	1.0	0.7	0.2	-0.8
Patch foraging time to switch 0 sec	1.3	2.7	5.7	2.4	-0.9	-1.3	2.1	-1.0
Patch foraging water rate 0 sec	1.7	3.6	7.6	-2.7	1.7	1.9	-2.0	-0.0
Patch foraging water rate 12 sec	0.8	1.7	4.1	-2.0	0.7	1.1	-1.5	0.6
Patch foraging water rate 18 sec	0.7	1.0	2.1	-0.6	-1.3	-1.0	-0.3	1.4
Patch foraging water rate 24 sec	2.0	2.8	6.7	-2.6	0.1	0.1	-2.2	1.6
Patch foraging water rate 6 sec	1.2	1.8	3.0	-1.7	1.2	1.7	-1.2	-0.6
Seeking ratio, delayed vs. immediate footshock	1.7	2.1	3.2	1.6	-1.3	-1.6	1.8	-0.5
Distance traveled before self-admin	0.8	1.0	1.9	1.4	-0.3	-0.2	1.4	-1.1
Distance traveled after self-admin	0.1	0.1	0.2	0.2	0.1	0.4	0.4	0.4
Extensor digitorum longus weight	1.4	5.5	8.0	-2.6	2.8	2.6	-2.2	-1.2
Bone: elastic displacement	1.1	1.3	2.4	-0.3	-1.3	-1.6	-0.4	1.5
Bone: elastic work	1.9	2.4	5.5	-2.3	0.9	0.7	-2.2	0.7
Bone: endosteal estimation	0.9	1.9	3.6	-1.8	0.9	1.0	-1.9	0.8
Bone: endosteal perimeter	0.9	2.0	2.9	-1.7	1.7	1.4	-1.5	-0.2
Epididymis fat weight	1.1	3.6	6.5	-0.9	2.4	2.2	-0.7	-2.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.5	0.2	0.1	-0.3	-0.3
Delta time in open arm before/after self-admin	3.5	3.4	6.9	2.6	-1.8	-1.9	1.8	0.4
Diff in mean of infusions in LGA sessions	0.3	0.3	1.1	0.3	-0.5	0.3	1.1	-0.2
Delay discount exponential model param	0.8	0.8	1.3	-1.1	1.1	1.2	-0.4	-0.6
Extinction: sum of active levers before priming	1.0	1.1	2.5	-0.6	1.4	1.6	-0.2	-0.7
Active lever presses in extinction session 6	2.4	2.4	4.3	-1.1	1.9	2.1	-1.2	-1.1
Bone: final force	1.0	1.6	3.5	-1.9	0.9	1.2	-1.5	0.6
Bone: final moment	0.9	1.4	3.1	-1.8	0.8	1.2	-1.3	0.6
Food consumed during 24 hour testing period	1.2	1.7	3.5	0.4	-1.7	-1.9	-0.1	1.4
Glucose	0.6	0.9	1.6	1.3	-0.3	-0.2	1.3	-1.0
Heart weight	1.1	1.6	3.2	-1.8	1.1	0.7	-1.7	0.6
Delay discount hyperbolic model param	0.6	0.7	1.1	-1.0	1.0	1.0	-0.2	-0.5
Intermittent access intake day 1-15 change	0.1	0.3	0.5	-0.7	0.4	0.4	-0.7	0.1
Intermittent access intake escalation	0.1	0.2	0.3	-0.5	0.5	0.6	-0.6	-0.2
Intermittent access intake escalation 2	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.8	-0.9	0.8	0.6	-0.1	-0.2
Intermitt. access day 15 inactive lever presses	1.0	2.1	5.5	2.3	-0.6	-0.2	2.0	-0.7
Intermitt. access escalation Index	0.1	0.2	0.4	-0.4	0.3	0.5	-0.7	0.0
Intermittent access day 1 total infusions	1.6	2.6	4.2	1.1	-2.0	-2.0	1.0	1.7
Intermittent access day 15 total infusions	0.4	0.6	1.0	0.4	-1.0	-1.0	-0.1	0.9
Intermittent access terminal intake (last 3 days)	0.7	1.0	1.8	0.9	-1.3	-1.3	0.1	0.7
Intermittent access total infusions	1.0	1.2	2.0	1.0	-1.4	-1.4	0.2	0.8
Intermittent access day 1 locomotion	0.8	1.1	2.0	1.1	-1.3	-1.4	0.2	0.6
Intermittent access day 15 total locomotion	1.0	1.9	4.0	0.7	-2.0	-1.6	0.3	1.4
Intermittent access total locomotion	1.0	1.2	2.1	1.0	-1.5	-1.4	0.0	1.0
Intermittent access standard deviation	0.1	0.2	0.6	0.2	-0.1	-0.4	0.0	-0.8
Left kidney weight	6.1	28.2	41.4	-6.4	5.9	5.7	-5.2	-2.1
Right kidney weight	5.9	26.7	38.2	-6.2	5.7	5.4	-5.4	-2.1
Cocaine induced anxiety	0.2	0.4	0.8	0.9	-0.5	-0.5	0.3	0.5
Post-drug Anxiety	2.4	2.5	6.4	2.5	-1.3	-1.1	1.8	-0.3
Baseline Anxiety	1.2	1.4	3.2	1.8	-0.4	-0.2	1.2	-1.5
Tail length	3.1	12.1	29.0	-5.4	1.8	1.4	-4.7	2.2
Length with tail	7.5	32.6	63.6	-8.0	5.4	4.9	-6.8	0.3
Length without tail	9.3	29.9	43.3	-6.1	6.6	6.3	-4.9	-2.4
Times rat made contact with spout	1.4	1.6	2.9	-1.6	-0.3	-0.0	-1.7	1.5
Lifetime Intake	1.1	1.3	2.0	1.3	-1.4	-1.4	0.4	0.7
Liver weight, left	4.3	7.2	9.6	-2.9	3.1	3.0	-2.9	-0.4
Liver weight, right	3.5	6.0	9.5	-3.1	2.5	2.4	-2.9	-0.3
Locomotor activity	0.7	1.2	3.7	-1.9	0.5	0.9	-0.9	0.5
Locomotor testing distance	0.4	0.7	1.8	-1.3	0.7	1.2	-0.2	-0.2
Locomotor testing rearing	0.0	0.1	0.3	0.0	0.0	0.5	0.3	0.0
Locomotion in novel chamber	3.6	4.6	11.1	-1.5	-1.8	-2.0	-1.6	3.3
Locomotion in novel chamber post-restriction	2.0	3.3	7.1	-2.0	-1.0	-1.4	-1.6	2.7
Fecal boli incidents, locomotor time 1	1.2	1.7	3.6	-1.9	1.0	1.0	-1.7	-0.2
Change in fecal boli incidents, locomotor task	0.7	0.7	1.2	1.1	-0.9	-0.8	1.0	-0.2
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.3	1.1	0.4	0.2	1.0	-0.6
Bouts of movement, locomotor time 1	0.3	0.3	1.1	-1.0	-0.1	-0.0	-0.5	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.8	-0.9	-0.2	0.2	-0.0	0.2
Rest time, locomotor task time 1	0.5	0.7	1.7	-0.5	-1.3	-0.7	0.8	0.6
Distance moved, locomotor task time 1	0.3	0.4	0.9	-0.2	0.8	0.7	-1.0	0.1
Vertical activity count, locomotor time 1	0.6	1.5	2.4	-1.2	1.4	1.2	-1.5	-0.2
Time >=10cm from walls, locomotor time 2	0.6	0.8	1.8	-0.6	1.2	1.3	-0.2	-0.7
Bouts of movement, locomotor time 2	1.8	2.9	4.9	-1.8	2.2	2.0	-1.4	-0.7
Total resting periods, locomotor time 2	1.5	2.7	5.1	-1.5	2.3	2.0	-0.9	-1.0
Rest time, locomotor task time 2	0.6	0.8	1.7	1.0	-0.7	-0.8	1.3	0.0
Distance moved, locomotor task time 2	1.3	1.5	3.1	-1.8	0.6	0.9	-1.7	0.7
Vertical activity count, locomotor time 2	2.0	2.8	6.7	-2.6	1.3	1.3	-2.0	0.1
Light reinforcement 1	0.6	1.6	3.2	1.8	-1.1	-0.8	1.7	-0.1
Light reinforcement 2	0.4	0.6	1.2	0.9	-0.4	-0.5	1.1	-0.7
Bone: marrow area	0.8	1.8	3.4	-1.7	0.8	1.0	-1.8	0.9
Bone: maximum diameter	1.0	1.9	3.8	-1.5	2.0	1.4	-1.2	-0.5
Bone: maximum force	1.2	2.1	3.2	-1.8	1.5	1.7	-1.4	0.2
Bone: maximum moment	1.1	1.9	3.0	-1.7	1.4	1.6	-1.3	0.3
Mean time between licks in bursts	0.3	0.7	1.1	1.0	-0.8	-1.1	0.8	0.3
Mean num. licks in bursts	0.4	0.6	0.8	0.9	-0.8	-0.8	0.5	0.7
Cd content in liver	1.0	1.1	2.0	-0.6	-1.2	-1.3	-0.3	1.4
Co content in liver	1.8	2.1	4.0	0.9	-2.0	-1.8	0.7	1.4
Cu content in liver	0.6	0.7	1.3	-0.7	0.9	1.1	-0.1	-0.9
Fe content in liver	5.4	6.6	11.0	-1.6	3.3	3.2	-1.3	-2.7
K content in liver	0.1	0.1	0.3	0.4	-0.3	-0.6	0.2	0.2
Mg content in liver	0.7	0.7	1.2	0.8	-1.1	-1.1	0.7	0.3
Mn content in liver	0.3	0.4	0.8	-0.5	-0.2	-0.2	-0.8	0.9
Na content in liver	0.4	0.4	0.7	-0.6	0.8	0.5	-0.8	-0.3
Rb content in liver	2.1	2.5	5.3	2.1	-1.0	-1.0	2.3	-0.8
Se content in liver	1.5	1.8	5.3	0.4	1.5	1.1	0.5	-2.3
Sr content in liver	0.8	0.7	1.6	-1.3	0.3	0.1	-1.0	0.9
Zn content in liver	1.6	1.8	3.7	-1.9	1.2	1.1	-1.6	-0.3
Bone: minimum diameter	0.0	0.0	0.1	-0.0	-0.0	0.0	0.2	0.3
Time in familiar zone, hab. session 1	0.4	0.4	0.9	-0.3	0.9	0.9	-0.3	-0.4
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.8	0.2	0.5	-0.7	-0.1
Total zone transitions, hab. session 1	1.7	2.4	6.3	-0.5	-1.5	-1.7	-0.6	2.5
Total locomotion distance, hab. session 1	0.6	0.8	1.0	0.8	-1.0	-1.0	0.9	1.0
Locomotion velocity, hab. session 1	1.8	2.6	3.2	1.7	-1.7	-1.8	1.6	1.1
Time in familiar zone, hab. session 2	1.6	1.7	3.8	-0.0	1.5	2.0	0.1	-1.6
Time in novel zone, hab. session 2	1.3	1.3	3.1	0.5	-1.4	-1.8	0.4	1.1
Total zone transitions, hab. session 2	2.3	3.0	7.5	-1.1	-1.4	-1.6	-1.3	2.7
Total locomotion distance, hab. session 2	1.8	2.4	4.1	0.6	-1.8	-2.0	0.5	2.0
Locomotion velocity, hab. session 2	2.0	2.6	4.6	0.6	-1.9	-2.2	0.5	2.1
Novel to familiar place preference ratio	0.2	0.2	0.5	0.3	-0.7	-0.6	0.1	0.4
Novelty place preference	0.1	0.1	0.2	0.3	-0.5	-0.3	-0.1	0.2
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.3	0.2
Total zone transitions, NPP test	1.2	1.7	3.7	-1.2	-0.4	-0.9	-1.6	1.9
Total locomotion distance, NPP test	1.0	1.4	2.8	0.7	-1.3	-1.7	0.5	1.4
Locomotion velocity, NPP test	1.4	2.0	3.8	0.7	-1.7	-1.9	0.5	1.7
Intraocular pressure	0.3	0.4	0.8	-0.2	0.7	0.6	-0.4	-0.9
Delta distance traveled before/after self-admin	1.3	1.4	3.6	-1.2	0.0	0.1	-1.4	1.9
Delta ambulatory time before/after self-admin	0.5	0.6	2.4	-0.6	0.0	0.2	-0.6	1.6
Parametrial fat weight	0.7	1.7	2.9	-0.7	1.7	1.6	-0.1	-1.7
Pavlov. Cond. lever latency	3.6	4.5	6.6	-2.0	2.5	2.6	-1.9	-1.4
Pavlov. Cond. magazine entry latency	1.1	1.4	3.4	-0.1	-1.3	-1.5	-0.2	1.8
Pavlov. Cond. change in total contacts	0.6	0.6	0.9	0.7	-0.9	-0.9	0.9	0.4
Pavlov. Cond. index score	1.6	2.0	3.3	1.0	-1.7	-1.8	0.9	1.5
Pavlov. Cond. latency score	2.1	2.7	4.3	1.1	-2.0	-2.1	1.1	1.7
Pavlov. Cond. lever contacts	4.1	4.9	6.7	2.2	-2.5	-2.6	2.1	1.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.2	-0.0	1.1	1.3	0.1	-1.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.2	0.4	0.6	0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	3.1	1.0	-1.6	-1.8	0.9	1.3
Pavlov. Cond. response bias	1.4	1.7	3.2	0.6	-1.6	-1.8	0.5	1.5
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.2	0.3	0.4	-0.5	0.0
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	0.8	-0.1	-0.8	0.5	-0.3
Pavlov. Cond. change in total contacts	0.1	0.2	0.7	-0.9	0.2	0.0	-0.6	0.1
Pavlov. Cond. index score	0.1	0.2	0.5	0.2	-0.3	-0.7	0.4	0.1
Pavlov. Cond. latency score	0.1	0.1	0.5	0.3	-0.2	-0.7	0.4	0.1
Pavlov. Cond. lever contacts	0.2	0.3	0.9	0.5	-0.4	-0.4	0.9	-0.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.7	0.2	0.6	-0.7	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.9	-0.3	0.2	-0.8	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.1	-0.2	-0.6	0.3	0.1
Pavlov. Cond. response bias	0.5	0.6	1.5	0.9	-0.5	-0.6	1.2	-0.4
Time in closed arm before self-admin	1.8	2.4	5.4	-2.3	0.6	0.3	-2.3	0.7
Time in closed arm after self-admin	4.0	4.3	10.9	-2.9	1.0	0.6	-3.3	0.8
Time in open arm before self-admin	0.3	0.3	0.7	-0.1	0.7	0.8	0.6	0.0
Time in open arm after self-admin	2.4	2.7	5.4	2.3	-1.4	-1.1	2.2	0.3
Bone: periosteal estimation	1.1	2.3	3.8	-1.9	1.6	1.5	-1.8	0.2
Bone: periosteal perimeter	1.3	2.3	4.9	-1.3	2.2	1.8	-1.0	-0.9
Bone: post-yield work	0.3	0.5	1.3	-0.2	1.0	1.1	-0.1	-0.2
Progressive ratio test 1 active lever presses	0.6	0.7	1.3	-0.5	-0.7	-0.5	-1.1	1.2
Progressive ratio test 1 breakpoint	0.6	0.7	1.3	-0.5	-0.7	-0.5	-1.1	1.1
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	0.2	-0.5	-0.7	0.1	0.7
Progressive ratio test 2 active lever presses	0.9	1.1	1.5	-0.8	-0.8	-1.0	-1.2	1.2
Progressive ratio test 2 breakpoint	0.9	1.0	1.4	-0.7	-0.8	-1.0	-1.2	1.2
Progressive ratio test 2 inactive lever presses	0.3	0.6	1.4	-1.2	-0.2	-0.4	-0.7	0.8
Incentive Sensitization - Responses	0.4	0.6	1.6	0.4	-0.8	-1.3	0.6	0.6
Incentive Sensitization - Breakpoint	0.5	0.6	1.6	0.4	-0.7	-1.3	0.5	0.6
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.4	-0.6	1.5	1.5	-0.7	-0.4
Progressive ratio	0.4	0.7	1.9	1.4	-0.8	-0.6	0.6	0.2
Food seeking constrained by brief footshock	0.2	0.3	0.9	0.0	0.6	0.3	-1.0	-0.3
Seeking ratio, punishment vs. effort	1.1	1.6	3.6	-1.9	0.8	0.6	-1.8	0.2
Retroperitoneal fat weight	1.6	6.9	12.4	-0.7	3.5	3.2	-0.5	-3.4
Reaction time number correct	0.8	1.5	3.0	-1.7	1.1	1.1	-1.2	0.5
Reaction time mean minus median	1.0	2.6	4.8	1.2	-2.2	-2.0	0.8	1.5
Reaction time mean minus median AUC	1.2	3.2	4.9	1.8	-2.2	-2.1	1.3	1.3
Reaction time num false alarms	0.2	0.3	0.7	0.2	-0.7	-0.9	-0.1	0.5
Reaction time num false alarms AUC	0.0	0.0	0.1	0.1	-0.3	-0.3	-0.0	0.0
Reaction time trials correct on left	0.8	1.5	3.0	-1.7	1.1	1.1	-1.2	0.5
Reaction time trials on left	0.7	1.4	2.9	-1.7	1.0	1.1	-1.2	0.5
Reaction time mean	3.5	5.6	9.0	3.0	-2.7	-2.3	2.5	0.4
Reaction time mean AUC	3.3	5.3	8.8	3.0	-2.6	-2.3	2.4	0.3
Median of all reaction times	3.7	5.3	9.7	3.1	-2.3	-2.0	2.7	-0.1
Reaction time omissions	0.7	1.0	1.8	1.3	-1.2	-0.9	0.9	0.3
Reaction time false alarm rate	0.2	0.3	0.6	0.8	-0.6	-0.6	0.4	-0.3
Reaction time premature initiation rate	4.1	5.7	9.9	1.6	-3.1	-3.1	1.1	2.3
Reaction time premature initiations	1.9	3.4	6.1	0.6	-2.3	-2.3	0.4	2.5
Std. dev. reaction times	1.8	3.4	5.8	1.9	-2.4	-2.2	1.3	1.0
Reaction time trials completed	0.7	1.4	2.9	-1.7	1.0	1.1	-1.2	0.5
Reaction time trials AUC	0.8	1.4	2.8	-1.7	1.1	1.1	-1.3	0.4
Run reversals in cocaine runway, females	1.1	1.1	2.5	1.6	-0.9	-0.9	1.2	0.3
Run reversals in cocaine runway, males	0.5	0.5	1.0	-0.8	1.0	0.9	-0.3	-0.4
Latency to leave start box in cocaine runway	2.6	2.9	6.0	1.1	1.2	1.8	1.6	-2.5
Latency to leave start box in cocaine runway, F	2.4	2.7	6.8	0.5	1.5	1.7	1.0	-2.6
Latency to leave start box in cocaine runway, M	0.3	0.3	1.1	-0.0	0.4	1.0	0.3	-0.1
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.1	-0.4	-0.5	-0.1	-0.1
Total sessions with >9 infusions	0.2	0.2	0.8	0.9	-0.1	-0.3	-0.0	-0.2
Short access day 1 total inactive lever presses	0.2	0.3	0.9	-0.5	0.5	-0.2	-1.0	0.0
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.1	0.5	-0.1	0.3	-0.4
Short access day 1 total infusions	0.2	0.3	1.2	1.1	-0.1	-0.4	0.5	-0.1
Short access day 10 total infusions	0.5	0.6	1.7	1.3	-0.6	-0.7	0.1	0.8
Short access total infusions	0.9	1.1	2.8	1.7	-1.0	-1.0	0.9	0.3
Short access day 1 locomotion	0.2	0.3	0.7	0.5	-0.6	-0.8	-0.3	0.3
Short access day 10 total locomotion	0.3	0.5	1.6	-0.3	0.7	0.4	-1.3	-0.5
Short access total locomotion	0.3	0.3	0.6	0.8	-0.5	-0.7	-0.5	0.1
One hour access (0.3 mA shock)	2.2	2.5	4.7	-0.1	-2.1	-2.2	-0.2	1.8
Compulsive drug intake	1.1	1.3	1.9	1.4	-1.2	-1.1	1.3	0.5
One hour access (shock baseline)	0.6	0.9	1.3	-0.8	-0.7	-0.8	-1.1	1.1
Social response proportion	1.4	1.6	3.3	-1.8	0.1	-0.0	-1.7	1.3
Social responses	0.7	0.9	2.4	-0.7	-0.6	-0.7	-0.9	1.5
Social time	0.8	1.1	1.6	1.2	-1.3	-1.1	1.2	0.0
Soleus weight	1.0	2.9	5.6	-1.3	2.4	2.0	-1.5	-1.0
Bone: stiffness	0.3	0.5	1.0	-0.6	0.9	1.0	-0.6	-0.0
Tibialis anterior weight	2.3	7.9	13.3	-3.6	2.8	2.3	-3.6	0.0
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.0	0.3	-0.2	0.0	1.0	-0.9
Time to tail flick, vehicle, after self-admin	1.5	1.9	3.6	-1.1	1.9	1.8	-0.9	-0.8
Time to tail flick, test, before self-admin	2.1	2.2	3.9	-2.0	1.5	1.3	-1.8	-0.1
Time to tail flick, test, after self-admin	0.3	0.3	0.8	0.7	0.4	0.5	-0.2	-0.9
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.5	-0.5	1.9	1.8	-1.0	-1.0
Delta time to tail flick, test, before/after SA	1.0	1.0	2.7	1.6	-1.0	-0.8	1.0	0.0
Tibia length	2.7	7.5	12.3	-3.5	2.8	2.9	-2.9	-0.7
Ambulatory time before self-admin	0.3	0.4	0.8	0.9	-0.2	-0.2	0.7	-0.7
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	-0.0	0.2	0.2	0.4
Bone: tissue strength	1.6	1.6	2.2	-1.4	1.5	1.3	-1.4	-0.1
Total heroin consumption	1.4	1.7	3.6	1.9	-1.2	-1.0	1.5	0.1
Bone: trabecular number	5.1	8.4	12.0	-3.1	3.4	3.5	-2.8	-1.1
Bone: trabecular spacing	0.8	1.1	2.6	1.6	-0.7	-0.8	1.2	-0.6
Bone: trabecular thickness	3.5	4.3	7.8	-1.7	2.6	2.8	-1.4	-1.4
Bone: trabecular tissue density	0.7	1.0	2.7	0.8	0.6	0.6	0.9	-1.6
Water consumed over 24 hours	1.3	1.7	3.2	-1.8	-0.1	-0.1	-1.6	1.6
Number of responses in last shaping day	0.0	0.0	0.1	0.3	-0.0	0.3	0.0	-0.2