Hub : Genes

Vps16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	mRNA stability	Vps16	0.11	0.08	1.6e-04	0.06	0.08	0.04	0.03	9.0e-04	3.4e-04	8.9e-03	2.1e-02
2	Brain	mRNA stability	Vps16	0.04	0.03	8.3e-04	0.03	0.03	0.03	0.03	5.7e-04	6.8e-04	1.8e-03	9.7e-04
3	NAcc	gene expression	Vps16	0.02	0.02	6.3e-03	0.01	0.01	0.01	0.01	1.1e-02	9.4e-03	1.5e-02	7.6e-03
4	Liver	gene expression	Vps16	0.16	0.1	0.0e+00	0.12	0.13	0.12	0.12	1.1e-13	8.0e-14	1.3e-13	1.1e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.4	0.6	0.9	1.0	-0.7	-0.8	-0.5
Area under the delay curve	0.3	0.4	0.7	-0.6	0.8	0.4	0.4
BMI with tail	1.2	4.0	4.9	1.9	-2.2	-2.0	-1.9
BMI without tail	3.7	7.6	8.1	2.8	-2.6	-2.8	-2.8
Body weight	6.2	26.0	29.0	5.1	-5.4	-4.8	-5.0
Weight adjusted by age	3.3	3.7	5.0	2.2	-1.7	-1.7	-2.0
Bone surface	0.6	1.0	1.5	1.2	-0.9	-0.9	-0.9
Bone volume	0.6	1.0	1.4	1.2	-1.0	-1.0	-0.8
Breakpoint value in progressive ratio session	3.2	3.6	4.0	1.8	-2.0	-1.9	-1.9
Number of licking bursts	0.2	0.2	0.5	-0.6	0.3	0.7	0.2
Context. condit. distance diff. score	0.0	0.1	0.1	0.3	-0.4	-0.0	0.1
Locomotion velocity, session 1	0.2	0.2	0.5	0.7	-0.0	-0.4	-0.5
Locomotion distance, session 1	0.2	0.2	0.6	0.8	-0.1	-0.4	-0.1
Locomotion velocity, session 2	0.2	0.2	0.5	-0.2	0.7	0.4	0.4
Locomotion distance, session 2	1.1	1.5	2.3	1.5	-1.0	-1.4	-0.9
Locomotion velocity, session 3	1.2	1.4	1.5	1.2	-1.1	-1.2	-1.2
Locomotion distance, session 3	7.0	7.6	8.6	2.7	-2.9	-2.8	-2.6
Stereotopy head waving bouts, day 3	1.1	1.3	1.9	-0.9	1.4	1.0	1.3
Stereotopy head waving duration, day 3	0.7	0.9	1.3	-0.8	1.1	0.8	1.0
Locomotion velocity, session 7	1.1	1.2	1.6	1.1	-1.3	-1.1	-0.9
Locomotion distance, session 7	0.5	0.6	0.9	1.0	-0.7	-0.9	-0.6
Stereotopy head waving bouts, day 7	0.6	0.7	0.8	0.7	-0.8	-0.8	-0.9
Stereotopy head waving duration, day 7	0.2	0.3	0.4	0.4	-0.6	-0.4	-0.6
Locomotion velocity, session 8	0.5	0.6	1.3	0.8	-1.1	-0.4	-0.3
Locomotion distance, session 8	1.8	2.7	4.0	2.0	-1.8	-1.5	-1.1
Degree of sensitization distance	2.4	2.4	2.7	-1.4	1.6	1.5	1.6
Degree of sensitization stereotypy	2.7	2.9	3.4	1.6	-1.7	-1.7	-1.9
Conditioned locomotion	3.7	4.3	5.9	2.4	-1.6	-2.2	-2.0
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.3	0.3	0.4	0.5
Cocaine response after cond. not corrected	0.2	0.2	0.3	-0.4	0.5	0.5	0.6
Cocaine response before conditioning	0.1	0.1	0.2	-0.5	0.4	0.2	0.3
Saline control response	7.2	9.4	10.4	3.2	-2.9	-3.1	-3.0
Bone: connectivity density	0.1	0.2	0.4	0.6	-0.3	-0.5	-0.2
Bone: cortical apparent density	0.6	0.8	1.3	0.8	-0.6	-1.0	-1.2
Bone: cortical area	3.5	5.2	5.4	2.3	-2.3	-2.3	-2.2
Bone: cortical porosity	0.2	0.2	0.3	0.1	-0.5	-0.2	-0.6
Bone: cortical porosity	0.5	0.6	0.9	0.5	-0.9	-0.6	-1.0
Bone: cortical thickness	1.5	2.5	2.6	1.6	-1.5	-1.6	-1.6
Bone: cortical thickness	0.3	0.4	0.4	0.6	-0.6	-0.6	-0.6
Bone: cortical tissue density	0.5	0.7	1.1	0.7	-0.5	-0.9	-1.1
Condit. Reinf. active minus inactive responses	1.0	1.1	1.6	0.8	-1.2	-1.0	-1.0
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.7	0.9	-1.3	-1.1	-0.9
Condit. Reinf. active responses	0.6	0.7	0.8	0.7	-0.9	-0.9	-0.9
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.0	0.3	0.1	0.0
Incentive salience index mean	0.5	0.6	0.7	0.7	-0.8	-0.8	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.1	0.2	-0.2	-0.3	-0.3
Condit. Reinf. active minus inactive responses	2.7	3.3	5.0	1.9	-1.4	-2.2	-1.6
Condit. Reinf. active-inactive response ratio	2.7	2.8	3.8	1.7	-1.5	-1.9	-1.5
Condit. Reinf. active responses	4.0	5.6	7.8	2.5	-1.9	-2.8	-2.2
Condit. Reinf. inactive responses	0.7	0.8	1.2	1.1	-0.7	-1.0	-0.8
Condit. Reinf. lever presses	1.6	2.1	2.5	1.5	-1.2	-1.6	-1.5
Condit. Reinf. lever reinforcers received	3.1	4.4	6.2	2.2	-1.6	-2.5	-1.9
Conditioned reinforcement - actives	0.0	0.0	0.0	0.1	0.1	0.0	-0.1
Conditioned reinforcement - inactives	0.4	0.4	0.8	0.8	-0.3	-0.9	-0.4
Conditioned locomotion	0.0	0.1	0.1	-0.3	-0.0	0.2	0.3
Patch foraging indifference point 0 sec	0.1	0.1	0.3	0.6	-0.1	-0.3	-0.1
Patch foraging indifference point AUC	0.6	0.6	0.7	0.8	-0.8	-0.8	-0.8
Delay disc. indifference point, 0s delay	2.2	2.4	3.4	-1.9	1.3	1.4	1.6
Delay disc. indifference point, 16s delay	0.9	1.0	1.7	-1.0	1.3	0.8	0.7
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.2	0.1	0.3	0.1
Delay disc. indifference point, 24s delay	3.2	3.1	4.2	-1.7	2.0	1.7	1.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.0	-0.2	-0.4	-0.3
Delay disc. indifference point, 8s delay	0.4	0.4	0.8	-0.7	0.9	0.4	0.3
Indifference point function ln k	0.0	0.1	0.1	0.4	-0.1	-0.2	-0.1
Indifference point function log k	0.0	0.1	0.1	0.4	-0.1	-0.2	-0.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	0.6	-0.2	-0.3	-0.1
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	0.8	-0.6	-0.5	-0.6
Patch foraging total patch changes 18 sec	0.7	0.9	1.2	-0.8	0.8	1.1	1.1
Patch foraging total patch changes 24 sec	1.5	1.8	2.3	-1.1	1.2	1.5	1.5
Patch foraging total patch changes 6 sec	0.6	0.8	1.1	1.1	-1.0	-1.0	-0.5
Patch foraging time to switch 0 sec	2.1	3.2	4.2	-2.0	1.6	1.9	1.5
Patch foraging water rate 0 sec	4.3	6.9	8.5	2.9	-2.5	-2.9	-2.2
Patch foraging water rate 12 sec	0.1	0.1	0.2	0.4	-0.4	0.1	-0.1
Patch foraging water rate 18 sec	0.5	0.7	1.1	0.7	-1.0	-0.8	-0.6
Patch foraging water rate 24 sec	0.5	0.7	0.9	0.8	-0.8	-0.7	-0.9
Patch foraging water rate 6 sec	2.1	3.1	3.6	1.8	-1.9	-1.6	-1.7
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.7	-0.5	0.5	0.8	0.4
Distance traveled before self-admin	5.4	5.7	7.4	2.5	-2.7	-2.2	-2.1
Distance traveled after self-admin	3.4	3.8	5.7	2.0	-2.4	-1.7	-1.7
Extensor digitorum longus weight	0.1	0.4	1.1	0.5	-1.0	-0.3	-0.5
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.2
Bone: elastic work	0.1	0.1	0.2	0.0	-0.5	-0.3	-0.3
Bone: endosteal estimation	0.5	1.2	1.8	1.1	-1.3	-0.9	-0.9
Bone: endosteal perimeter	2.3	4.8	5.5	2.3	-2.3	-2.1	-2.0
Epididymis fat weight	1.3	3.0	3.5	1.9	-1.9	-1.4	-1.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.6	0.5	0.0	0.5
Delta time in open arm before/after self-admin	1.1	1.1	2.7	1.2	-1.6	-0.2	-0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.2	0.1	0.1	0.1
Delay discount exponential model param	0.3	0.3	0.7	0.6	-0.8	-0.4	-0.3
Extinction: sum of active levers before priming	1.0	1.0	1.2	0.9	-1.1	-1.0	-0.9
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.3	0.3	0.3	0.5
Bone: final force	3.4	5.6	6.2	2.5	-2.1	-2.4	-2.4
Bone: final moment	2.7	4.4	4.8	2.2	-2.0	-2.1	-2.1
Food consumed during 24 hour testing period	0.8	1.0	1.1	-1.0	1.0	1.0	1.1
Glucose	0.6	0.8	1.4	0.8	-1.2	-1.0	-0.5
Heart weight	3.1	4.4	5.6	2.4	-1.9	-2.3	-1.8
Delay discount hyperbolic model param	0.2	0.2	0.5	0.5	-0.7	-0.3	-0.3
Intermittent access intake day 1-15 change	0.6	0.6	1.2	0.7	-1.1	-0.6	-0.5
Intermittent access intake escalation	0.2	0.2	0.3	0.4	-0.5	-0.4	-0.3
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.4	0.0	0.5	0.5
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.3	-0.3	0.4	-0.3	0.6
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.1	0.0	-0.5	0.3
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.4	0.2	0.5	0.3
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.1	-0.3	-0.1	0.0
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	0.1	-0.2	-0.1	0.2
Intermittent access total infusions	0.0	0.0	0.1	-0.1	0.0	0.1	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.3	0.6	0.2	0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.3	-0.0	0.2	0.1	0.5
Intermittent access total locomotion	0.1	0.1	0.2	-0.2	0.2	0.4	0.5
Intermittent access standard deviation	0.1	0.2	0.4	0.2	-0.3	-0.6	-0.3
Left kidney weight	1.0	2.8	3.2	1.8	-1.8	-1.7	-1.4
Right kidney weight	0.9	2.6	3.4	1.8	-1.5	-1.8	-1.3
Cocaine induced anxiety	4.7	5.4	6.9	-2.4	2.6	1.6	2.6
Post-drug Anxiety	1.4	1.6	2.4	-1.3	1.6	0.6	1.4
Baseline Anxiety	0.5	0.6	0.8	0.8	-0.9	-0.4	-0.9
Tail length	4.9	14.8	15.6	3.9	-3.8	-3.8	-4.0
Length with tail	4.7	17.1	18.6	4.3	-4.3	-3.8	-4.1
Length without tail	1.5	3.3	4.6	1.8	-2.1	-1.5	-1.6
Times rat made contact with spout	0.0	0.0	0.0	0.0	0.1	0.1	0.2
Lifetime Intake	0.1	0.1	0.3	0.4	-0.6	-0.3	-0.2
Liver weight, left	0.0	0.1	0.3	-0.1	-0.1	-0.0	0.5
Liver weight, right	0.0	0.1	0.1	0.1	-0.3	-0.2	-0.2
Locomotor activity	0.1	0.2	0.3	0.4	-0.0	-0.5	-0.6
Locomotor testing distance	0.1	0.1	0.4	-0.3	0.6	0.1	0.3
Locomotor testing rearing	0.2	0.4	0.8	0.7	0.0	-0.9	-0.5
Locomotion in novel chamber	0.1	0.1	0.2	-0.4	0.5	0.1	0.3
Locomotion in novel chamber post-restriction	1.3	1.6	2.6	1.2	-1.0	-1.6	-1.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.3	0.4	0.6	0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	-0.3	-0.2	-0.3
Bouts of movement, locomotor time 1	2.2	2.4	2.9	-1.7	1.5	1.5	1.4
Total resting periods, locomotor time 1	1.7	1.9	2.3	-1.5	1.4	1.3	1.2
Rest time, locomotor task time 1	0.3	0.3	0.4	-0.6	0.6	0.6	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.2	-0.4	-0.5	-0.0
Vertical activity count, locomotor time 1	0.2	0.2	0.3	0.4	-0.5	-0.5	-0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.1	-0.2	0.1	0.0
Bouts of movement, locomotor time 2	0.5	0.5	0.9	-1.0	0.3	0.9	0.6
Total resting periods, locomotor time 2	0.5	0.5	0.9	-1.0	0.3	0.9	0.5
Rest time, locomotor task time 2	0.3	0.4	0.6	-0.7	0.8	0.6	0.3
Distance moved, locomotor task time 2	0.0	0.0	0.2	0.1	0.0	-0.1	0.4
Vertical activity count, locomotor time 2	0.2	0.2	0.6	0.6	-0.3	-0.8	0.0
Light reinforcement 1	0.9	1.6	2.2	1.3	-0.8	-1.5	-1.4
Light reinforcement 2	0.7	0.9	1.2	0.9	-0.7	-1.1	-1.0
Bone: marrow area	0.5	1.1	1.7	1.1	-1.3	-0.9	-0.9
Bone: maximum diameter	4.5	8.3	9.1	3.0	-2.9	-2.9	-2.7
Bone: maximum force	0.6	1.0	1.3	1.1	-0.8	-1.0	-1.0
Bone: maximum moment	0.2	0.4	0.5	0.7	-0.6	-0.6	-0.6
Mean time between licks in bursts	0.2	0.2	0.8	-0.1	-0.9	0.0	0.0
Mean num. licks in bursts	0.1	0.2	0.4	0.6	-0.1	-0.6	-0.1
Cd content in liver	0.1	0.1	0.2	-0.4	0.4	-0.0	0.4
Co content in liver	0.8	0.9	1.1	1.0	-0.9	-1.0	-0.9
Cu content in liver	1.9	2.3	2.9	1.7	-1.4	-1.4	-1.5
Fe content in liver	0.0	0.0	0.1	0.1	-0.2	0.0	0.1
K content in liver	0.2	0.2	0.3	0.5	-0.3	-0.3	-0.5
Mg content in liver	1.5	1.6	1.9	1.4	-1.2	-1.2	-1.2
Mn content in liver	1.7	1.9	2.4	1.5	-0.9	-1.5	-1.5
Na content in liver	0.1	0.1	0.2	-0.2	0.4	0.5	0.3
Rb content in liver	4.2	5.2	7.6	2.4	-2.7	-2.0	-1.8
Se content in liver	0.6	0.8	1.1	1.1	-0.6	-0.8	-0.9
Sr content in liver	0.7	0.6	1.1	0.6	-0.8	-1.0	-0.7
Zn content in liver	0.2	0.2	0.3	0.5	-0.2	-0.6	-0.4
Bone: minimum diameter	1.7	3.2	4.3	1.8	-2.1	-1.7	-1.6
Time in familiar zone, hab. session 1	1.3	1.2	1.4	-1.1	0.8	1.2	1.2
Time in novel zone, hab. session 1	0.4	0.4	0.5	0.7	-0.3	-0.7	-0.6
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	0.1	-0.4	-0.1
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.3	0.4	-0.2	0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.4	0.4	-0.4	0.0
Time in familiar zone, hab. session 2	1.6	1.6	1.9	-1.3	1.2	1.1	1.4
Time in novel zone, hab. session 2	1.6	1.6	1.9	1.3	-1.2	-1.1	-1.4
Total zone transitions, hab. session 2	2.1	2.7	3.3	1.8	-1.3	-1.7	-1.7
Total locomotion distance, hab. session 2	0.5	0.6	1.2	1.1	-0.2	-1.0	-0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.6	0.8	0.2	-0.6	-0.2
Novel to familiar place preference ratio	0.1	0.2	0.3	-0.3	0.1	0.5	0.5
Novelty place preference	0.3	0.3	0.6	-0.5	0.3	0.7	0.7
Time in novel zone, NPP test	0.2	0.2	0.3	-0.4	0.1	0.5	0.6
Total zone transitions, NPP test	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4
Total locomotion distance, NPP test	0.1	0.2	0.4	0.6	0.3	-0.5	-0.1
Locomotion velocity, NPP test	0.1	0.2	0.5	0.3	0.7	-0.1	0.2
Intraocular pressure	0.0	0.0	0.1	0.1	-0.1	0.1	-0.2
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.4	-0.5	-0.4	-0.5
Delta ambulatory time before/after self-admin	0.5	0.5	0.7	-0.8	0.7	0.7	0.6
Parametrial fat weight	0.1	0.2	0.3	-0.5	0.5	0.5	0.4
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.5	-0.3	-0.6	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	-0.2	-0.4	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.1
Pavlov. Cond. index score	0.0	0.0	0.0	-0.0	-0.1	0.0	0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.3	0.2	0.3	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.0
Pavlov. Cond. magazine entry number	0.6	0.8	0.9	-0.7	0.9	0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.4	-0.6	-0.4	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.1	0.0	0.1
Pavlov. Cond. response bias	0.4	0.5	0.7	0.7	-0.8	-0.8	-0.6
Pavlov. Cond. lever latency	4.2	5.7	6.3	-2.4	2.1	2.5	2.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.2
Pavlov. Cond. change in total contacts	4.0	5.6	6.2	2.3	-2.2	-2.4	-2.5
Pavlov. Cond. index score	3.6	4.6	4.8	2.1	-2.1	-2.2	-2.1
Pavlov. Cond. latency score	2.8	3.4	3.9	1.9	-1.8	-2.0	-1.8
Pavlov. Cond. lever contacts	4.2	5.8	5.9	2.4	-2.3	-2.4	-2.4
Pavlov. Cond. magazine entry number	0.7	0.9	1.0	-0.9	1.0	1.0	0.9
Pavlov. Cond. intertrial magazine entries	1.3	1.7	2.1	-1.2	1.5	1.3	1.2
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.1	4.1	2.0	-2.0	-2.0	-2.0
Pavlov. Cond. response bias	4.6	6.3	6.4	2.5	-2.5	-2.5	-2.5
Time in closed arm before self-admin	0.2	0.2	0.4	-0.5	0.2	0.6	0.5
Time in closed arm after self-admin	0.5	0.5	0.9	-1.0	0.5	0.6	0.7
Time in open arm before self-admin	0.5	0.5	1.7	-0.5	1.3	-0.1	0.3
Time in open arm after self-admin	0.1	0.1	0.3	0.6	-0.3	-0.0	-0.1
Bone: periosteal estimation	2.5	5.1	5.9	2.3	-2.4	-2.2	-2.1
Bone: periosteal perimeter	3.8	6.2	8.2	2.5	-2.9	-2.4	-2.1
Bone: post-yield work	0.6	0.8	0.9	-0.9	0.9	0.9	0.9
Progressive ratio test 1 active lever presses	2.3	2.4	2.8	1.6	-1.7	-1.3	-1.6
Progressive ratio test 1 breakpoint	3.1	3.2	3.8	1.8	-2.0	-1.6	-1.8
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.7	0.6	-0.5	-0.8	-0.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.5	-0.6	-0.2	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.4	-0.5	-0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.8	0.5	-0.2	-0.9	-0.1
Incentive Sensitization - Responses	0.2	0.2	0.7	0.4	-0.8	-0.1	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.2	-0.7	0.2	-0.0
Sum of active levers in priming session hrs 5-6	1.1	1.1	1.4	1.2	-0.8	-1.2	-1.0
Progressive ratio	2.9	3.3	4.3	-1.9	2.1	1.7	1.6
Food seeking constrained by brief footshock	0.4	0.5	1.2	0.8	-0.4	-1.1	-0.2
Seeking ratio, punishment vs. effort	3.1	3.8	4.4	2.1	-2.1	-2.1	-1.5
Retroperitoneal fat weight	0.0	0.1	0.3	-0.2	0.1	0.5	0.3
Reaction time number correct	0.3	0.4	0.7	0.8	-0.4	-0.7	-0.5
Reaction time mean minus median	0.8	1.1	1.4	-1.0	1.2	1.1	1.0
Reaction time mean minus median AUC	0.5	0.7	0.9	-0.7	1.0	0.8	0.8
Reaction time num false alarms	1.8	2.5	3.1	1.8	-1.4	-1.6	-1.4
Reaction time num false alarms AUC	1.9	2.6	3.1	1.8	-1.5	-1.6	-1.6
Reaction time trials correct on left	0.3	0.4	0.7	0.8	-0.4	-0.7	-0.5
Reaction time trials on left	0.3	0.5	0.8	0.9	-0.4	-0.8	-0.6
Reaction time mean	0.0	0.0	0.1	-0.2	-0.0	0.3	-0.0
Reaction time mean AUC	0.0	0.0	0.1	-0.2	0.0	0.3	0.1
Median of all reaction times	0.0	0.1	0.1	0.1	-0.4	0.2	-0.3
Reaction time omissions	0.4	0.6	1.0	0.8	-0.4	-1.0	-0.6
Reaction time false alarm rate	0.9	1.2	1.4	1.2	-1.1	-1.1	-1.1
Reaction time premature initiation rate	0.2	0.3	0.4	-0.5	0.6	0.6	0.3
Reaction time premature initiations	0.1	0.1	0.3	-0.2	0.6	0.4	0.1
Std. dev. reaction times	0.1	0.1	0.3	0.2	-0.1	-0.2	-0.5
Reaction time trials completed	0.3	0.5	0.8	0.9	-0.4	-0.8	-0.6
Reaction time trials AUC	0.4	0.5	0.8	0.9	-0.5	-0.8	-0.6
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.1	0.1	-0.2	0.2
Run reversals in cocaine runway, males	1.3	1.2	1.9	1.1	-1.1	-1.4	-0.8
Latency to leave start box in cocaine runway	0.7	0.7	0.8	-0.9	0.9	0.8	0.8
Latency to leave start box in cocaine runway, F	1.3	1.4	1.7	-1.3	1.2	1.0	1.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2
Std. dev. time between licks in bursts	0.6	0.7	1.3	0.8	-1.1	-0.6	-0.6
Total sessions with >9 infusions	0.5	0.6	1.1	0.6	-1.1	-0.5	-0.7
Short access day 1 total inactive lever presses	0.7	0.8	1.1	-0.9	1.1	0.7	0.8
Short access day 10 total inactive lever presses	3.1	3.4	5.2	-1.8	1.8	1.3	2.3
Short access day 1 total infusions	0.1	0.1	0.3	0.1	-0.5	-0.1	-0.0
Short access day 10 total infusions	0.0	0.0	0.1	-0.0	-0.2	-0.2	-0.0
Short access total infusions	0.4	0.4	1.1	0.5	-1.0	-0.3	-0.5
Short access day 1 locomotion	0.8	0.8	1.5	-0.8	0.3	1.0	1.2
Short access day 10 total locomotion	0.0	0.0	0.1	0.1	-0.3	0.0	-0.2
Short access total locomotion	0.0	0.0	0.1	0.1	-0.3	-0.2	0.0
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.1	0.1	0.4	0.3
Compulsive drug intake	4.6	4.7	5.7	-2.1	2.4	2.2	1.9
One hour access (shock baseline)	0.5	0.5	1.0	0.7	-1.0	-0.6	-0.4
Social response proportion	1.6	1.7	2.4	1.6	-1.0	-1.4	-1.2
Social responses	4.7	6.1	7.0	2.6	-2.0	-2.6	-2.5
Social time	0.4	0.5	0.7	0.8	-0.5	-0.7	-0.8
Soleus weight	0.0	0.1	0.2	0.3	-0.4	-0.0	-0.0
Bone: stiffness	1.6	2.6	3.1	1.8	-1.4	-1.6	-1.6
Tibialis anterior weight	0.9	3.0	3.4	1.7	-1.9	-1.7	-1.6
Time to tail flick, vehicle, before self-admin	2.2	2.3	3.6	-1.3	1.2	1.9	1.6
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.0
Time to tail flick, test, before self-admin	0.9	0.9	1.4	0.9	-0.6	-1.0	-1.2
Time to tail flick, test, after self-admin	2.0	2.1	2.7	-1.4	1.4	1.4	1.6
Delta time to tail flick, vehicle, before/after SA	4.0	4.0	6.5	1.9	-1.5	-2.5	-1.9
Delta time to tail flick, test, before/after SA	2.5	2.3	3.2	-1.4	1.3	1.5	1.8
Tibia length	5.0	14.1	18.1	3.6	-4.3	-3.5	-3.7
Ambulatory time before self-admin	4.3	4.5	5.5	2.2	-2.4	-1.9	-2.0
Ambulatory time after self-admin	4.2	4.6	7.0	2.2	-2.6	-1.8	-1.9
Bone: tissue strength	0.1	0.1	0.2	0.4	-0.0	-0.3	-0.4
Total heroin consumption	3.6	4.3	4.9	2.1	-1.8	-2.2	-2.1
Bone: trabecular number	0.6	0.9	1.3	1.1	-0.8	-1.0	-0.9
Bone: trabecular spacing	0.1	0.2	0.4	-0.4	0.6	0.2	0.2
Bone: trabecular thickness	0.5	0.6	1.0	0.7	-1.0	-0.6	-0.5
Bone: trabecular tissue density	1.2	1.7	2.2	1.5	-1.0	-1.4	-1.3
Water consumed over 24 hours	0.1	0.1	0.1	-0.3	0.4	0.4	0.2
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.2	-0.0	0.4