Hub : Genes

Vipr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Vipr2	0.03	0.03	1.0e-03	0.03	0.03	0.03	0.03	5.5e-04	6.8e-04	4.7e-04	4.2e-04
2	Adipose	isoform ratio	XM_017594055.3	0.03	0.03	7.9e-04	0.02	0.03	0.02	0.03	1.1e-03	6.2e-04	9.5e-04	6.7e-04
3	Adipose	alternative TSS	XM_017594055.3	0.03	0.03	2.0e-03	0.02	0.02	0.01	0.02	5.2e-03	1.9e-03	1.1e-02	6.1e-03
4	Adipose	alternative TSS	XM_017594055.3	0.03	0.03	9.7e-04	0.02	0.02	0.02	0.02	3.1e-03	1.0e-03	4.5e-03	3.0e-03
5	Brain	gene expression	Vipr2	0.03	0.03	3.9e-03	0.02	-0	0.02	-0	4.2e-03	8.6e-01	6.9e-03	5.2e-01
6	Liver	gene expression	Vipr2	0.46	0.2	1.5e-07	0.04	0.05	0.06	0.04	2.4e-05	2.2e-06	9.6e-07	1.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.4	0.7	0.8	-0.9	0.9	0.9	0.9	0.9	0.6
Area under the delay curve	0.8	1.0	1.4	1.2	-0.8	-0.8	-0.8	-1.1	1.1
BMI with tail	0.0	0.0	0.1	-0.3	0.1	0.1	0.1	0.0	-0.1
BMI without tail	0.1	0.4	0.5	0.4	-0.7	-0.7	-0.7	-0.7	-0.4
Body weight	2.9	12.5	14.4	3.7	-3.8	-3.8	-3.8	-3.5	-2.5
Weight adjusted by age	1.4	2.2	3.9	2.0	-1.6	-1.6	-1.6	-1.3	-0.4
Bone surface	3.7	6.7	7.9	-2.8	2.8	2.8	2.8	2.7	1.4
Bone volume	2.6	4.7	5.5	-2.3	2.3	2.3	2.3	2.3	1.2
Breakpoint value in progressive ratio session	3.1	3.8	4.7	2.0	-2.2	-2.2	-2.2	-1.8	-1.1
Number of licking bursts	0.2	0.3	0.5	-0.6	0.6	0.6	0.6	0.7	0.3
Context. condit. distance diff. score	0.9	1.1	1.5	1.2	-1.1	-1.1	-1.1	-1.1	-0.4
Locomotion velocity, session 1	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.2	-0.2	-0.3
Locomotion distance, session 1	0.6	0.7	0.8	-0.9	0.9	0.9	0.9	0.9	0.4
Locomotion velocity, session 2	0.2	0.3	0.4	-0.7	0.5	0.5	0.5	0.5	-0.1
Locomotion distance, session 2	2.6	3.6	4.4	-2.1	2.0	2.0	2.0	2.0	0.8
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	0.4	-0.0
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1	0.0
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	0.2	-0.3	-0.2	-0.2	-0.3	-0.2
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.1	-0.1	-0.2
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.1	-0.3
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	0.4	0.4	0.4	0.5	0.2
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	0.9	-1.0	-1.0	-1.0	-1.0	-0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.4	-0.5	-0.5	-0.5	-0.6	-0.1
Locomotion velocity, session 8	0.0	0.0	0.0	-0.2	0.2	0.2	0.2	0.1	-0.1
Locomotion distance, session 8	0.6	0.9	1.1	-0.9	1.0	1.0	1.0	1.0	0.6
Degree of sensitization distance	0.3	0.4	0.4	-0.6	0.6	0.6	0.6	0.6	0.4
Degree of sensitization stereotypy	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.4	-0.5	-0.1
Conditioned locomotion	0.3	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.6	-0.3
Cocaine response after cond. corrected	0.3	0.4	0.5	-0.7	0.7	0.7	0.7	0.6	0.4
Cocaine response after cond. not corrected	0.8	0.9	1.1	-1.0	1.0	1.0	1.0	0.9	0.7
Cocaine response before conditioning	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	0.3	0.3
Saline control response	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5	-0.5
Bone: connectivity density	0.7	1.1	1.3	-1.1	1.2	1.1	1.1	1.1	0.7
Bone: cortical apparent density	2.4	3.3	3.7	1.9	-1.9	-1.9	-1.9	-1.8	-1.3
Bone: cortical area	1.4	2.1	2.7	-1.6	1.6	1.6	1.6	1.6	0.7
Bone: cortical porosity	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.4	-0.5	-0.2
Bone: cortical porosity	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5	-0.3
Bone: cortical thickness	0.0	0.1	0.1	-0.3	0.2	0.2	0.2	0.3	-0.1
Bone: cortical thickness	0.5	0.5	0.6	-0.7	0.8	0.8	0.8	0.6	0.7
Bone: cortical tissue density	2.3	3.1	3.6	1.8	-1.9	-1.9	-1.9	-1.7	-1.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1	0.0
Condit. Reinf. active responses	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.1	-0.1
Condit. Reinf. inactive responses	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.0	-0.2
Incentive salience index mean	0.2	0.2	0.3	0.6	-0.5	-0.5	-0.5	-0.5	-0.3
Condit. Reinf. lever presses	0.3	0.5	0.6	0.8	-0.7	-0.7	-0.7	-0.7	-0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.1	0.1	-0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	0.6	0.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	0.2	-0.2
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	0.3	0.2
Condit. Reinf. lever presses	2.3	3.2	4.0	-2.0	1.9	1.9	1.9	1.9	0.8
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	-0.4	0.2	0.2	0.2	0.3	-0.1
Conditioned reinforcement - actives	0.4	0.7	2.1	0.5	-0.8	-0.8	-0.8	-0.1	-1.5
Conditioned reinforcement - inactives	1.9	2.8	3.1	1.7	-1.7	-1.7	-1.7	-1.4	-1.8
Conditioned locomotion	0.3	0.4	1.3	-0.0	-0.6	-0.6	-0.6	-0.4	-1.1
Patch foraging indifference point 0 sec	2.3	4.2	5.0	2.2	-2.1	-2.1	-2.1	-2.0	-1.7
Patch foraging indifference point AUC	0.7	1.0	1.5	1.2	-1.0	-1.0	-1.0	-1.2	0.2
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	0.5	-0.7	-0.7	-0.7	-0.9	0.2
Delay disc. indifference point, 16s delay	0.8	0.8	3.5	0.8	-0.2	-0.2	-0.2	-0.8	1.9
Delay disc. indifference point, 2s delay	0.8	0.9	1.0	-0.9	0.9	0.9	0.9	0.9	1.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.5	0.5	0.5	0.5	0.6	0.2
Delay disc. indifference point, 4s delay	1.1	1.2	1.6	1.3	-1.2	-1.2	-1.2	-1.1	0.0
Delay disc. indifference point, 8s delay	1.5	1.8	2.6	1.6	-1.2	-1.2	-1.2	-1.6	1.2
Indifference point function ln k	1.7	3.0	4.1	1.8	-1.8	-1.8	-1.8	-2.0	-1.0
Indifference point function log k	1.7	3.0	4.1	1.8	-1.8	-1.8	-1.8	-2.0	-1.0
Patch foraging total patch changes 0 sec	3.0	5.7	6.8	2.6	-2.5	-2.5	-2.5	-2.3	-1.9
Patch foraging total patch changes 12 sec	1.7	2.2	3.1	1.7	-1.5	-1.5	-1.5	-1.6	-0.9
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.4	-0.4	-0.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	-0.3	0.5	0.5	0.5	0.6	0.3
Patch foraging total patch changes 6 sec	1.2	1.9	2.9	1.7	-1.4	-1.4	-1.4	-1.5	-0.6
Patch foraging time to switch 0 sec	3.3	6.8	8.7	-2.9	2.8	2.8	2.8	2.9	0.9
Patch foraging water rate 0 sec	5.3	11.0	13.6	3.7	-3.6	-3.5	-3.5	-3.5	-1.6
Patch foraging water rate 12 sec	4.1	8.5	10.2	3.1	-3.1	-3.1	-3.1	-3.2	-1.3
Patch foraging water rate 18 sec	4.1	6.4	7.4	2.7	-2.7	-2.7	-2.7	-2.5	-1.6
Patch foraging water rate 24 sec	2.6	3.7	4.6	2.1	-2.1	-2.0	-2.0	-2.1	-0.7
Patch foraging water rate 6 sec	2.5	3.7	4.3	2.1	-2.1	-2.0	-2.0	-1.7	-1.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	1.0	-0.2	0.4	0.4	0.4	0.2	-1.0
Distance traveled before self-admin	0.3	0.4	0.8	-0.5	0.6	0.6	0.6	0.9	0.2
Distance traveled after self-admin	0.0	0.0	0.2	0.1	0.0	0.1	0.1	0.0	-0.4
Extensor digitorum longus weight	1.6	6.4	7.8	2.7	-2.7	-2.7	-2.7	-2.8	-1.3
Bone: elastic displacement	1.2	1.4	1.7	-1.2	1.3	1.3	1.3	1.3	0.7
Bone: elastic work	1.9	2.4	2.8	-1.6	1.7	1.7	1.7	1.6	1.1
Bone: endosteal estimation	2.5	5.4	6.1	-2.5	2.5	2.5	2.5	2.4	1.4
Bone: endosteal perimeter	1.6	3.3	3.7	-1.9	1.9	1.9	1.9	1.9	1.2
Epididymis fat weight	0.3	0.9	1.1	-0.9	1.0	1.0	1.0	0.9	0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.1	0.2	0.2	0.2	-0.4	-0.2
Delta time in open arm before/after self-admin	0.4	0.4	0.7	-0.8	0.6	0.6	0.6	0.6	0.4
Diff in mean of infusions in LGA sessions	0.8	1.0	1.3	1.1	-1.1	-1.1	-1.1	-0.8	-0.5
Delay discount exponential model param	0.9	1.0	1.6	-1.3	0.9	0.9	0.9	1.1	-0.9
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	-0.1	-0.1	-0.1	0.0	0.5
Active lever presses in extinction session 6	2.4	2.3	4.1	1.1	-1.6	-1.6	-1.6	-1.1	-2.0
Bone: final force	0.8	1.3	1.5	-1.2	1.2	1.2	1.2	1.1	0.8
Bone: final moment	0.7	1.1	1.2	-1.1	1.1	1.1	1.1	1.1	0.7
Food consumed during 24 hour testing period	2.4	3.3	4.0	2.0	-1.9	-1.9	-1.9	-2.0	-0.9
Glucose	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.5	-0.3
Heart weight	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	0.4	0.1
Delay discount hyperbolic model param	0.7	0.7	1.1	-1.1	0.8	0.8	0.8	0.9	-0.9
Intermittent access intake day 1-15 change	0.2	0.4	0.8	-0.9	0.5	0.5	0.5	0.4	0.8
Intermittent access intake escalation	0.3	0.5	1.1	-1.0	0.6	0.6	0.6	0.5	0.9
Intermittent access intake escalation 2	0.6	0.6	3.0	-0.6	0.4	0.4	0.4	0.0	1.7
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.1	0.3	0.3	0.3	-0.3	0.5
Intermitt. access day 15 inactive lever presses	0.7	1.4	2.1	1.5	-1.1	-1.1	-1.1	-1.2	-0.8
Intermitt. access escalation Index	0.1	0.2	0.4	0.6	-0.4	-0.4	-0.4	-0.1	-0.2
Intermittent access day 1 total infusions	0.2	0.2	1.3	-0.1	-0.2	-0.2	-0.2	-0.2	-1.1
Intermittent access day 15 total infusions	0.3	0.4	1.5	-0.3	-0.5	-0.5	-0.5	-0.3	-1.2
Intermittent access terminal intake (last 3 days)	0.3	0.4	1.4	-0.5	-0.4	-0.4	-0.4	-0.3	-1.2
Intermittent access total infusions	0.5	0.5	2.1	-0.0	-0.6	-0.6	-0.6	-0.4	-1.4
Intermittent access day 1 locomotion	0.5	0.7	1.9	-1.4	0.6	0.6	0.6	0.6	-0.9
Intermittent access day 15 total locomotion	0.3	0.5	1.1	-1.0	0.7	0.7	0.7	0.4	0.6
Intermittent access total locomotion	0.2	0.3	1.1	-1.1	0.4	0.4	0.4	0.1	-0.1
Intermittent access standard deviation	0.8	1.7	2.1	1.0	-1.5	-1.5	-1.5	-1.0	-1.4
Left kidney weight	1.0	4.8	5.5	2.4	-2.3	-2.3	-2.3	-2.0	-1.7
Right kidney weight	1.3	6.0	7.3	2.7	-2.6	-2.6	-2.6	-2.3	-1.6
Cocaine induced anxiety	0.4	0.6	1.4	0.8	-0.7	-0.7	-0.7	-1.2	0.3
Post-drug Anxiety	0.1	0.1	0.3	0.5	-0.1	-0.1	-0.1	-0.4	0.5
Baseline Anxiety	0.9	1.0	2.6	-0.6	1.0	1.0	1.0	1.6	0.2
Tail length	2.6	10.0	12.5	3.5	-3.4	-3.4	-3.3	-3.3	-1.7
Length with tail	5.4	23.4	29.8	5.5	-5.1	-5.1	-5.1	-5.0	-2.6
Length without tail	3.3	10.8	14.3	3.8	-3.5	-3.5	-3.5	-3.3	-1.7
Times rat made contact with spout	1.2	1.4	1.6	1.2	-1.2	-1.2	-1.2	-1.3	-0.7
Lifetime Intake	0.3	0.3	1.5	-0.3	-0.4	-0.4	-0.4	-0.2	-1.2
Liver weight, left	2.0	3.3	4.4	1.9	-1.9	-1.9	-1.9	-2.1	-1.1
Liver weight, right	3.9	6.8	8.1	2.7	-2.8	-2.8	-2.8	-2.5	-1.8
Locomotor activity	0.3	0.5	1.5	-0.3	0.7	0.7	0.7	0.3	1.2
Locomotor testing distance	0.4	0.7	1.4	-0.5	0.9	0.9	0.9	0.6	1.2
Locomotor testing rearing	1.1	2.2	2.5	-1.3	1.6	1.6	1.6	1.4	1.5
Locomotion in novel chamber	0.4	0.5	2.0	0.4	-0.5	-0.5	-0.5	-0.3	-1.4
Locomotion in novel chamber post-restriction	2.1	3.4	4.3	-2.1	1.9	1.9	1.9	1.9	1.2
Fecal boli incidents, locomotor time 1	0.2	0.3	0.6	0.5	-0.5	-0.6	-0.6	-0.4	-0.7
Change in fecal boli incidents, locomotor task	0.5	0.5	2.0	0.2	-0.5	-0.5	-0.5	-0.0	-1.4
Time >=10cm from walls, locomotor time 1	8.7	9.3	13.9	2.5	-3.2	-3.2	-3.2	-2.2	-3.7
Bouts of movement, locomotor time 1	0.7	0.8	1.7	1.3	-0.9	-0.9	-0.9	-0.6	0.3
Total resting periods, locomotor time 1	0.2	0.3	0.7	0.8	-0.3	-0.3	-0.3	0.1	0.9
Rest time, locomotor task time 1	0.4	0.4	1.8	0.2	-0.5	-0.5	-0.5	0.1	-1.4
Distance moved, locomotor task time 1	1.3	2.0	3.2	-1.8	1.5	1.5	1.6	0.9	0.9
Vertical activity count, locomotor time 1	0.6	1.5	1.8	-1.3	1.2	1.3	1.3	1.1	1.1
Time >=10cm from walls, locomotor time 2	0.5	0.7	1.0	0.5	-1.0	-1.0	-1.0	-0.3	-1.0
Bouts of movement, locomotor time 2	1.0	1.6	5.8	-0.7	1.0	1.0	1.0	0.2	2.4
Total resting periods, locomotor time 2	0.6	1.0	4.6	-0.4	0.6	0.6	0.6	-0.2	2.2
Rest time, locomotor task time 2	1.4	1.7	2.0	1.3	-1.4	-1.4	-1.4	-1.0	-1.3
Distance moved, locomotor task time 2	2.1	2.5	3.0	-1.7	1.7	1.7	1.7	1.3	1.3
Vertical activity count, locomotor time 2	0.5	0.7	0.9	-0.9	0.9	0.9	0.9	0.7	0.6
Light reinforcement 1	0.0	0.1	0.3	-0.1	0.2	0.2	0.2	0.1	0.5
Light reinforcement 2	0.2	0.2	0.3	0.4	-0.6	-0.6	-0.6	-0.5	-0.2
Bone: marrow area	2.5	5.5	6.2	-2.5	2.5	2.5	2.5	2.5	1.4
Bone: maximum diameter	0.9	1.7	2.1	-1.4	1.4	1.4	1.4	1.3	0.7
Bone: maximum force	0.4	0.6	0.8	-0.9	0.8	0.8	0.8	0.8	0.6
Bone: maximum moment	0.2	0.4	0.6	-0.7	0.7	0.7	0.7	0.6	0.5
Mean time between licks in bursts	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1	0.1
Mean num. licks in bursts	0.7	1.0	1.3	1.0	-1.1	-1.1	-1.1	-1.1	-0.5
Cd content in liver	1.3	1.4	1.6	1.3	-1.3	-1.3	-1.3	-1.2	-0.7
Co content in liver	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.2	0.1
Cu content in liver	0.5	0.6	0.7	-0.8	0.8	0.8	0.8	0.9	0.5
Fe content in liver	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1	0.1
K content in liver	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	0.7	0.3
Mg content in liver	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	0.4	0.2
Mn content in liver	0.7	0.8	0.9	-0.9	0.9	0.9	0.9	0.9	0.6
Na content in liver	1.0	1.1	1.5	-1.2	1.1	1.1	1.1	1.2	0.1
Rb content in liver	0.3	0.3	0.4	-0.5	0.6	0.6	0.6	0.6	0.5
Se content in liver	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.2	-0.0
Sr content in liver	0.3	0.3	0.3	-0.6	0.6	0.6	0.6	0.5	0.2
Zn content in liver	0.5	0.6	0.7	-0.8	0.8	0.8	0.8	0.8	0.6
Bone: minimum diameter	1.6	2.9	3.3	-1.8	1.8	1.8	1.8	1.8	1.0
Time in familiar zone, hab. session 1	1.6	1.6	1.8	-1.3	1.3	1.3	1.3	1.3	0.7
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1	-0.0
Total zone transitions, hab. session 1	3.3	4.6	5.2	-2.3	2.3	2.3	2.3	2.2	1.4
Total locomotion distance, hab. session 1	1.8	2.5	2.9	-1.6	1.7	1.7	1.7	1.6	1.0
Locomotion velocity, hab. session 1	0.6	0.8	1.0	-0.9	1.0	1.0	1.0	0.9	0.6
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.2	0.3	0.3	0.3	0.2	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	0.2	0.3	0.3	0.3	-0.0
Total zone transitions, hab. session 2	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	0.5	0.4
Total locomotion distance, hab. session 2	0.0	0.1	0.1	-0.2	0.3	0.3	0.3	0.2	0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.1
Novel to familiar place preference ratio	0.9	1.0	1.2	-1.0	1.0	1.0	1.0	1.1	0.5
Novelty place preference	1.0	1.1	1.3	-1.1	1.1	1.1	1.1	1.2	0.5
Time in novel zone, NPP test	0.6	0.6	0.8	-0.8	0.8	0.8	0.8	0.9	0.4
Total zone transitions, NPP test	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.2	-0.1
Total locomotion distance, NPP test	0.2	0.3	0.4	0.6	-0.6	-0.6	-0.6	-0.7	-0.3
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	-0.2
Intraocular pressure	1.8	2.6	4.2	-2.0	1.7	1.7	1.7	1.7	0.4
Delta distance traveled before/after self-admin	0.1	0.1	0.2	-0.4	0.2	0.2	0.2	-0.4	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	-0.0	-0.1	-0.1	-0.1	-0.6	0.3
Parametrial fat weight	0.1	0.1	0.3	-0.5	0.4	0.4	0.4	0.2	0.3
Pavlov. Cond. lever latency	0.6	0.7	1.0	-1.0	0.9	0.9	0.9	0.9	0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.2	-0.2	0.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.3	-0.3	0.0
Pavlov. Cond. index score	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.1
Pavlov. Cond. latency score	0.2	0.2	0.4	0.6	-0.5	-0.5	-0.5	-0.5	0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1	-0.1	0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	0.4	0.3	0.3	0.3	0.0
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.5	1.5	-1.5	-1.5	-1.5	-1.6	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.1	0.0	0.0	0.0	-0.0	0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.5	-0.4	-0.4	-0.4	-0.4	0.0
Pavlov. Cond. lever latency	1.8	2.4	3.0	1.7	-1.6	-1.6	-1.6	-1.7	-0.7
Pavlov. Cond. magazine entry latency	0.6	0.7	0.8	-0.9	0.9	0.9	0.9	0.9	0.5
Pavlov. Cond. change in total contacts	2.9	4.7	5.9	-2.3	2.3	2.3	2.3	2.4	1.1
Pavlov. Cond. index score	2.8	3.8	4.5	-2.1	2.1	2.1	2.1	2.1	1.0
Pavlov. Cond. latency score	1.6	2.2	2.6	-1.6	1.6	1.6	1.6	1.6	0.8
Pavlov. Cond. lever contacts	2.4	3.3	3.9	-1.9	1.9	1.9	1.9	2.0	1.0
Pavlov. Cond. magazine entry number	1.0	1.2	1.5	1.2	-1.1	-1.1	-1.1	-1.2	-0.5
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.2	1.1	-1.1	-1.1	-1.1	-1.1	-0.5
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.5	5.3	-2.3	2.2	2.2	2.2	2.3	1.1
Pavlov. Cond. response bias	2.2	3.0	3.5	-1.8	1.8	1.8	1.8	1.9	0.9
Time in closed arm before self-admin	0.4	0.5	0.6	-0.8	0.7	0.7	0.7	0.5	0.8
Time in closed arm after self-admin	0.2	0.3	0.4	-0.5	0.6	0.6	0.6	0.2	0.5
Time in open arm before self-admin	2.0	2.2	2.4	1.3	-1.5	-1.5	-1.5	-1.5	-1.6
Time in open arm after self-admin	0.3	0.3	0.4	0.5	-0.6	-0.6	-0.6	-0.3	-0.5
Bone: periosteal estimation	2.8	5.9	6.9	-2.6	2.6	2.6	2.6	2.5	1.4
Bone: periosteal perimeter	1.9	3.4	3.9	-2.0	1.9	1.9	1.9	1.9	1.2
Bone: post-yield work	0.5	0.8	0.9	0.9	-1.0	-1.0	-1.0	-0.9	-0.4
Progressive ratio test 1 active lever presses	0.3	0.4	2.1	-0.4	-0.1	-0.1	-0.1	-0.1	-1.4
Progressive ratio test 1 breakpoint	0.3	0.4	2.0	-0.4	-0.1	-0.1	-0.1	-0.0	-1.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.7	0.0	-0.0	-0.0	-0.0	0.3	-0.8
Progressive ratio test 2 active lever presses	0.6	0.7	1.1	0.5	-0.9	-0.9	-0.8	-1.0	-0.8
Progressive ratio test 2 breakpoint	0.7	0.8	1.3	0.6	-0.9	-0.9	-0.9	-1.1	-0.9
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.9	0.1	-0.3	-0.3	-0.2	-0.2	-1.0
Incentive Sensitization - Responses	0.3	0.4	0.9	0.6	-0.6	-0.6	-0.6	-0.9	0.5
Incentive Sensitization - Breakpoint	0.4	0.5	1.0	0.6	-0.7	-0.7	-0.7	-1.0	0.4
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	0.7	-0.8	-0.8	-0.8	-0.5	-0.3
Progressive ratio	1.3	2.1	3.3	-1.5	1.5	1.5	1.5	1.8	0.3
Food seeking constrained by brief footshock	2.1	2.5	3.8	-1.5	1.6	1.6	1.6	2.0	1.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.3	0.6	-0.6	-0.6	-0.5	-0.5	0.4
Retroperitoneal fat weight	0.0	0.1	0.4	0.2	-0.3	-0.3	-0.3	-0.6	0.1
Reaction time number correct	0.9	1.7	2.3	1.4	-1.4	-1.4	-1.4	-1.5	-0.4
Reaction time mean minus median	0.0	0.1	0.2	-0.3	0.2	0.2	0.2	0.4	-0.4
Reaction time mean minus median AUC	0.3	0.7	1.1	-0.9	0.8	0.8	0.8	1.1	-0.1
Reaction time num false alarms	0.1	0.2	0.7	-0.2	0.2	0.2	0.2	-0.4	0.8
Reaction time num false alarms AUC	0.1	0.1	0.5	-0.1	0.1	0.1	0.1	-0.3	0.7
Reaction time trials correct on left	0.9	1.7	2.3	1.4	-1.4	-1.4	-1.4	-1.5	-0.4
Reaction time trials on left	0.9	1.7	2.2	1.4	-1.4	-1.4	-1.4	-1.5	-0.4
Reaction time mean	0.4	0.6	1.0	-0.8	0.8	0.8	0.8	1.0	0.2
Reaction time mean AUC	0.2	0.3	0.5	-0.5	0.5	0.5	0.5	0.7	-0.0
Median of all reaction times	0.4	0.5	0.7	-0.7	0.8	0.8	0.7	0.8	0.3
Reaction time omissions	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.1	-0.1	-0.3
Reaction time false alarm rate	0.2	0.3	0.5	-0.6	0.5	0.5	0.5	0.2	0.7
Reaction time premature initiation rate	1.9	2.6	3.8	-1.7	1.7	1.7	1.7	2.0	0.5
Reaction time premature initiations	0.5	0.9	1.6	-0.9	1.0	1.0	1.0	1.3	0.3
Std. dev. reaction times	0.4	0.8	1.2	-1.0	1.0	1.0	1.0	1.1	0.1
Reaction time trials completed	0.9	1.7	2.2	1.4	-1.4	-1.4	-1.4	-1.5	-0.4
Reaction time trials AUC	0.7	1.3	1.8	1.3	-1.2	-1.2	-1.2	-1.4	-0.4
Run reversals in cocaine runway, females	0.2	0.2	1.0	-0.2	0.1	0.1	0.1	1.0	-0.6
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	0.3	0.3	0.3	-0.2	0.3
Latency to leave start box in cocaine runway	1.1	1.2	2.8	-0.7	1.1	1.1	1.1	1.7	0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	1.0	-0.0	0.4	0.4	0.4	1.0	0.5
Latency to leave start box in cocaine runway, M	2.0	1.9	2.3	-1.3	1.5	1.5	1.5	1.4	0.9
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.0	-0.0
Total sessions with >9 infusions	0.3	0.3	0.7	-0.9	0.4	0.4	0.4	0.5	-0.8
Short access day 1 total inactive lever presses	1.1	1.5	5.3	0.4	-1.0	-1.1	-1.1	-0.5	-2.3
Short access day 10 total inactive lever presses	0.4	0.9	1.9	1.4	-0.9	-0.9	-0.9	-0.9	0.4
Short access day 1 total infusions	0.5	0.7	3.4	-0.2	-0.5	-0.5	-0.6	0.0	-1.8
Short access day 10 total infusions	0.3	0.4	1.5	-0.7	0.2	0.2	0.2	0.3	-1.2
Short access total infusions	0.2	0.2	0.8	-0.7	0.1	0.1	0.1	0.1	-0.9
Short access day 1 locomotion	0.3	0.4	1.4	-0.7	0.2	0.2	0.2	0.5	-1.2
Short access day 10 total locomotion	0.2	0.3	0.7	-0.9	0.4	0.4	0.4	0.4	-0.6
Short access total locomotion	0.2	0.2	0.9	-0.5	0.1	0.1	0.1	0.4	-1.0
One hour access (0.3 mA shock)	0.6	0.7	0.9	0.6	-0.9	-0.9	-0.9	-0.8	-0.9
Compulsive drug intake	0.1	0.2	0.4	-0.5	0.4	0.4	0.4	0.6	-0.1
One hour access (shock baseline)	1.3	2.0	2.4	1.3	-1.5	-1.6	-1.5	-1.3	-1.2
Social response proportion	0.1	0.1	0.2	-0.5	0.1	0.1	0.1	0.1	-0.2
Social responses	1.9	2.5	2.8	-1.6	1.7	1.7	1.7	1.4	1.4
Social time	0.0	0.0	0.1	0.1	-0.2	-0.2	-0.2	-0.1	-0.2
Soleus weight	1.3	3.7	4.5	2.0	-2.1	-2.1	-2.0	-2.1	-1.0
Bone: stiffness	0.7	1.1	1.3	1.1	-1.1	-1.1	-1.1	-1.1	-0.4
Tibialis anterior weight	0.3	0.9	1.3	0.9	-1.0	-1.0	-1.0	-1.1	-0.4
Time to tail flick, vehicle, before self-admin	1.9	2.0	2.4	1.5	-1.6	-1.6	-1.6	-1.5	-0.2
Time to tail flick, vehicle, after self-admin	1.8	2.4	4.5	-2.1	1.5	1.5	1.5	1.6	0.6
Time to tail flick, test, before self-admin	0.9	1.0	1.7	-1.1	0.9	0.9	0.9	1.3	0.7
Time to tail flick, test, after self-admin	1.3	1.4	2.4	1.6	-1.3	-1.3	-1.3	-0.9	-0.5
Delta time to tail flick, vehicle, before/after SA	2.6	2.5	3.7	-1.7	1.6	1.6	1.6	1.9	0.3
Delta time to tail flick, test, before/after SA	2.2	2.3	4.0	2.0	-1.5	-1.4	-1.4	-1.8	-0.2
Tibia length	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.5	-0.4	-0.3
Ambulatory time before self-admin	0.1	0.1	0.6	0.1	0.3	0.3	0.3	0.8	-0.0
Ambulatory time after self-admin	0.2	0.2	0.4	-0.3	0.5	0.5	0.5	0.6	-0.2
Bone: tissue strength	2.6	2.6	3.1	1.8	-1.7	-1.7	-1.7	-1.7	-0.8
Total heroin consumption	0.5	0.6	0.9	0.4	-0.9	-0.9	-0.9	-0.9	-0.4
Bone: trabecular number	0.1	0.2	0.2	-0.4	0.4	0.4	0.4	0.5	0.4
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	0.2	0.2	0.2	0.2	0.0
Bone: trabecular thickness	0.8	1.0	1.2	-1.1	1.1	1.1	1.1	1.1	0.6
Bone: trabecular tissue density	0.2	0.3	0.3	0.4	-0.5	-0.5	-0.5	-0.5	-0.5
Water consumed over 24 hours	1.4	1.9	2.2	1.5	-1.5	-1.5	-1.5	-1.5	-0.8
Number of responses in last shaping day	0.2	0.2	1.0	-0.4	-0.1	-0.1	-0.1	-0.2	-1.0