Hub : Genes

Vinac1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Vinac1 0.28 0.13 4.0e-13 0.2 0.22 0.23 0.21 4.8e-11 8.4e-12 3.0e-12 2.9e-11
2 NAcc gene expression Vinac1 0.03 0.02 5.2e-05 0.03 0.03 0.03 0.03 4.5e-05 3.8e-05 9.3e-06 8.5e-06
3 Brain mRNA stability Vinac1 0.08 0.05 2.5e-06 0.05 0.06 0.06 0.06 1.2e-05 1.5e-06 1.7e-06 2.7e-06
4 NAcc mRNA stability Vinac1 0.05 0.03 3.7e-07 0.03 0.04 0.03 0.03 2.4e-05 3.7e-06 6.0e-06 1.5e-05
5 PL gene expression Vinac1 0.19 0.09 0.0e+00 0.16 0.19 0.2 0.2 5.8e-17 5.1e-20 3.1e-21 6.9e-21
6 pVTA mRNA stability Vinac1 0.22 0.12 1.1e-16 0.22 0.21 0.21 0.22 5.6e-18 5.3e-17 4.9e-17 2.6e-17
7 IC gene expression Vinac1 0.31 0.14 1.4e-11 0.25 0.22 0.25 0.24 6.6e-11 1.7e-09 6.8e-11 1.6e-10
8 BLA mRNA stability Vinac1 0.2 0.11 3.0e-07 0.11 0.1 0.1 0.11 1.6e-06 5.3e-06 8.7e-06 2.1e-06
9 Adipose gene expression Vinac1 0.43 0.14 0.0e+00 0.28 0.29 0.3 0.3 2.6e-31 4.4e-32 2.4e-33 3.1e-33
10 PL mRNA stability Vinac1 0.13 0.08 9.8e-12 0.08 0.09 0.1 0.09 3.4e-09 2.1e-10 2.2e-11 3.5e-10
11 pVTA gene expression Vinac1 0.04 0.03 1.8e-03 0.03 0.03 0.03 0.02 4.0e-03 1.7e-03 2.6e-03 5.5e-03
12 IC mRNA stability Vinac1 0.35 0.16 5.4e-12 0.26 0.24 0.27 0.25 3.7e-11 1.4e-10 1.4e-11 5.3e-11
13 LHb mRNA stability Vinac1 0.25 0.15 4.1e-03 0.03 0.04 0.03 0.03 6.5e-02 4.5e-02 6.9e-02 5.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.72.94.82.21.9-1.9-1.91.9-1.71.7-1.6-1.6-1.51.2-1.6-1.1
Area under the delay curve0.30.40.6-0.7-0.80.60.6-0.60.6-0.60.60.70.4-0.40.70.4
BMI with tail0.20.71.30.60.7-0.6-0.60.8-1.01.0-0.9-1.0-0.91.1-0.6-1.2
BMI without tail2.57.710.02.22.2-2.4-2.32.6-3.03.1-3.0-3.0-3.03.2-2.6-3.2
Body weight3.314.516.83.73.7-3.7-3.73.8-4.14.1-4.1-3.7-4.03.7-3.6-3.6
Weight adjusted by age2.74.26.62.62.6-2.3-2.32.2-2.02.1-1.9-1.8-1.51.3-2.3-1.1
Bone surface1.01.93.21.81.6-1.6-1.61.6-1.31.3-1.3-1.2-1.10.9-1.1-0.8
Bone volume1.22.13.71.91.8-1.7-1.71.6-1.41.4-1.4-1.3-1.20.9-1.1-0.8
Breakpoint value in progressive ratio session0.91.01.31.00.9-1.1-1.11.1-1.01.0-1.0-1.0-1.01.1-0.7-1.1
Number of licking bursts0.50.86.90.50.7-0.2-0.00.2-0.80.8-0.8-0.3-0.70.5-2.6-0.4
Context. condit. distance diff. score1.21.44.51.61.6-1.2-1.11.0-1.11.2-1.2-0.6-1.00.3-2.1-0.1
Locomotion velocity, session 10.30.42.8-0.5-0.50.20.1-0.40.5-0.50.50.30.3-0.41.70.3
Locomotion distance, session 10.50.61.41.21.0-1.1-1.10.8-0.70.7-0.7-0.5-0.70.2-0.3-0.1
Locomotion velocity, session 20.10.10.3-0.5-0.50.20.2-0.30.1-0.10.10.3-0.0-0.20.30.1
Locomotion distance, session 21.72.44.21.91.9-2.0-2.01.8-1.51.5-1.5-1.4-1.41.0-0.4-0.9
Locomotion velocity, session 31.31.52.10.70.7-0.9-0.91.1-1.41.4-1.4-1.4-1.41.4-1.0-1.4
Locomotion distance, session 38.39.011.52.62.8-2.8-2.83.0-3.33.3-3.3-3.4-3.23.2-2.1-3.2
Stereotopy head waving bouts, day 32.32.74.6-1.0-1.01.21.1-1.31.9-1.91.91.91.8-2.11.42.1
Stereotopy head waving duration, day 32.42.93.5-1.5-1.61.51.5-1.61.9-1.91.91.81.7-1.81.61.7
Locomotion velocity, session 72.22.44.61.71.5-1.4-1.31.4-1.71.7-1.7-1.3-1.71.2-2.1-1.0
Locomotion distance, session 73.44.37.32.62.7-2.2-2.12.1-2.02.1-2.1-1.6-1.81.3-2.5-1.1
Stereotopy head waving bouts, day 70.10.10.4-0.5-0.50.20.2-0.1-0.30.2-0.2-0.2-0.50.50.1-0.6
Stereotopy head waving duration, day 70.30.30.9-0.9-0.90.60.6-0.50.3-0.40.40.30.10.00.8-0.1
Locomotion velocity, session 80.50.61.00.90.8-1.0-1.00.9-0.80.9-0.9-0.8-0.70.5-0.4-0.4
Locomotion distance, session 84.56.511.03.33.2-3.0-2.92.7-2.52.6-2.6-2.1-2.21.5-2.4-1.3
Degree of sensitization distance1.01.02.9-0.1-0.20.60.6-0.81.1-1.01.01.51.1-1.6-0.21.7
Degree of sensitization stereotypy1.11.22.40.40.4-0.8-0.80.9-1.31.3-1.3-1.2-1.41.5-0.6-1.6
Conditioned locomotion1.21.42.41.51.5-1.5-1.61.4-1.11.1-1.1-1.1-1.10.80.2-0.8
Cocaine response after cond. corrected0.10.10.3-0.3-0.20.30.2-0.30.4-0.40.40.50.3-0.50.40.5
Cocaine response after cond. not corrected0.30.30.9-0.6-0.40.40.4-0.50.6-0.60.60.50.6-0.61.00.5
Cocaine response before conditioning0.20.31.4-0.6-0.40.40.4-0.40.5-0.50.50.20.6-0.21.20.1
Saline control response4.76.37.42.62.5-2.7-2.72.7-2.62.7-2.7-2.5-2.62.4-1.3-2.3
Bone: connectivity density0.71.22.01.41.2-1.2-1.21.3-1.01.0-1.0-1.0-0.90.7-1.1-0.6
Bone: cortical apparent density0.30.41.7-0.00.2-0.3-0.40.3-0.30.3-0.3-0.8-0.30.81.3-0.9
Bone: cortical area3.04.65.72.32.2-2.4-2.42.3-2.32.3-2.3-2.2-2.12.0-1.1-1.9
Bone: cortical porosity0.60.62.3-1.5-1.41.01.0-0.60.2-0.20.20.20.10.40.7-0.5
Bone: cortical porosity0.20.30.8-0.8-0.80.30.30.0-0.30.3-0.3-0.3-0.30.70.3-0.9
Bone: cortical thickness0.81.32.00.91.1-1.3-1.31.3-1.21.1-1.1-1.4-1.01.30.6-1.4
Bone: cortical thickness0.20.30.50.20.3-0.4-0.40.5-0.60.5-0.5-0.7-0.60.70.2-0.7
Bone: cortical tissue density0.20.31.8-0.20.1-0.2-0.20.2-0.20.1-0.1-0.6-0.20.61.3-0.8
Condit. Reinf. active minus inactive responses0.40.40.80.50.8-0.7-0.80.8-0.50.5-0.5-0.8-0.40.80.2-0.9
Condit. Reinf. active-inactive response ratio0.60.71.31.01.2-1.0-1.01.0-0.60.6-0.6-0.8-0.50.7-0.1-0.7
Condit. Reinf. active responses0.10.20.30.30.5-0.5-0.50.5-0.30.3-0.3-0.5-0.30.50.2-0.6
Condit. Reinf. inactive responses0.00.00.2-0.2-0.10.10.1-0.30.2-0.20.20.20.2-0.30.40.3
Incentive salience index mean0.20.20.60.60.8-0.6-0.70.6-0.30.3-0.3-0.5-0.10.40.1-0.4
Condit. Reinf. lever presses0.10.10.30.50.6-0.4-0.40.4-0.30.2-0.2-0.2-0.00.1-0.5-0.1
Condit. Reinf. active minus inactive responses2.83.75.02.22.1-2.2-2.22.1-2.02.0-2.0-1.8-1.91.6-0.8-1.5
Condit. Reinf. active-inactive response ratio3.64.25.82.42.3-2.2-2.22.2-2.22.1-2.1-2.0-1.91.7-1.7-1.5
Condit. Reinf. active responses3.54.96.82.42.2-2.6-2.62.4-2.32.3-2.3-2.2-2.32.0-0.4-2.0
Condit. Reinf. inactive responses0.30.40.60.50.5-0.7-0.80.6-0.50.6-0.6-0.6-0.70.60.4-0.6
Condit. Reinf. lever presses1.21.62.01.31.1-1.4-1.41.3-1.41.4-1.4-1.3-1.41.3-0.5-1.2
Condit. Reinf. lever reinforcers received2.94.05.62.32.1-2.3-2.42.2-2.12.1-2.1-2.0-2.01.8-0.6-1.7
Conditioned reinforcement - actives0.30.51.10.40.5-0.5-0.40.5-0.80.6-0.7-0.9-0.80.9-1.0-0.9
Conditioned reinforcement - inactives0.50.72.11.41.4-1.1-1.21.0-0.70.5-0.5-0.6-0.40.1-0.30.0
Conditioned locomotion0.20.31.00.40.3-0.3-0.30.5-0.60.5-0.6-0.7-0.50.7-1.0-0.7
Patch foraging indifference point 0 sec0.10.10.40.40.5-0.3-0.40.10.10.1-0.00.30.1-0.60.20.7
Patch foraging indifference point AUC0.60.91.21.01.0-1.0-1.01.0-1.10.8-0.9-1.0-0.90.9-0.3-0.8
Delay disc. indifference point, 0s delay4.34.86.1-2.5-2.52.32.2-2.32.3-2.12.22.32.1-1.92.01.7
Delay disc. indifference point, 16s delay0.30.40.4-0.6-0.60.60.6-0.60.6-0.60.60.70.5-0.60.50.6
Delay disc. indifference point, 2s delay0.20.20.4-0.4-0.50.40.4-0.50.4-0.40.30.60.3-0.40.30.4
Delay disc. indifference point, 24s delay1.11.31.8-1.3-1.31.11.1-1.21.1-1.21.21.21.0-1.00.91.0
Delay disc. indifference point, 4s delay0.00.00.1-0.1-0.2-0.0-0.00.1-0.20.1-0.1-0.1-0.30.3-0.0-0.4
Delay disc. indifference point, 8s delay0.10.10.3-0.6-0.60.50.5-0.50.3-0.30.30.40.1-0.10.20.1
Indifference point function ln k0.20.30.60.70.7-0.7-0.70.6-0.50.7-0.7-0.4-0.50.3-0.5-0.3
Indifference point function log k0.20.30.60.70.7-0.7-0.70.6-0.50.7-0.7-0.4-0.50.3-0.5-0.3
Patch foraging total patch changes 0 sec0.10.10.40.50.6-0.4-0.50.20.10.2-0.10.20.1-0.50.10.6
Patch foraging total patch changes 12 sec0.00.00.10.1-0.1-0.2-0.20.2-0.10.1-0.2-0.2-0.20.10.4-0.1
Patch foraging total patch changes 18 sec0.50.71.9-0.4-0.40.60.6-0.80.8-0.80.81.10.9-1.30.31.4
Patch foraging total patch changes 24 sec0.71.23.6-0.2-0.30.70.7-0.91.0-1.01.11.41.2-1.7-0.11.9
Patch foraging total patch changes 6 sec0.40.61.41.21.1-1.0-1.00.9-0.70.7-0.6-0.5-0.50.1-0.30.0
Patch foraging time to switch 0 sec2.04.17.8-2.7-2.82.52.5-2.21.9-1.81.91.71.8-1.31.31.1
Patch foraging water rate 0 sec3.06.410.83.23.3-3.0-3.02.8-2.42.4-2.4-2.4-2.21.7-1.8-1.6
Patch foraging water rate 12 sec0.61.22.61.41.6-1.2-1.21.0-1.01.1-1.1-1.0-1.00.6-0.8-0.4
Patch foraging water rate 18 sec0.50.71.00.81.0-0.8-0.80.9-0.80.8-0.8-1.0-0.90.8-0.7-0.8
Patch foraging water rate 24 sec0.81.21.61.01.2-1.0-1.01.0-1.01.3-1.3-1.3-1.11.1-0.9-1.0
Patch foraging water rate 6 sec2.13.13.71.91.9-1.9-1.91.8-1.81.8-1.7-1.8-1.71.5-1.3-1.4
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.4-0.30.40.4-0.40.3-0.10.40.30.5-0.40.20.4
Distance traveled before self-admin3.95.27.52.72.7-2.6-2.62.5-2.32.4-2.3-2.0-2.11.7-1.6-1.5
Distance traveled after self-admin2.42.95.41.71.7-1.6-1.61.7-1.71.7-1.8-1.6-1.61.5-2.3-1.5
Extensor digitorum longus weight0.20.62.80.50.5-0.5-0.40.5-0.80.8-0.8-0.6-0.70.7-1.7-0.7
Bone: elastic displacement0.10.20.6-0.4-0.30.10.10.1-0.30.3-0.3-0.5-0.30.7-0.4-0.8
Bone: elastic work0.10.10.4-0.2-0.10.00.00.1-0.30.3-0.3-0.5-0.20.6-0.1-0.6
Bone: endosteal estimation1.22.66.71.91.6-1.5-1.41.4-1.71.8-1.8-1.2-1.50.9-2.6-0.7
Bone: endosteal perimeter2.24.87.62.82.5-2.4-2.42.3-2.22.2-2.2-2.0-2.11.6-1.9-1.4
Epididymis fat weight0.10.50.8-0.9-0.80.90.9-0.80.7-0.70.70.70.6-0.50.10.4
Delta time in closed arm before/after self-admin0.20.20.4-0.6-0.60.60.6-0.70.4-0.20.30.40.4-0.4-0.20.4
Delta time in open arm before/after self-admin0.30.30.80.90.9-0.8-0.80.7-0.40.3-0.3-0.3-0.20.10.2-0.0
Diff in mean of infusions in LGA sessions0.40.50.7-0.5-0.80.70.7-0.60.6-0.70.80.70.5-0.60.80.6
Delay discount exponential model param0.30.30.50.70.7-0.5-0.50.6-0.50.6-0.5-0.6-0.30.4-0.6-0.3
Extinction: sum of active levers before priming0.10.10.30.00.1-0.2-0.30.3-0.10.0-0.3-0.4-0.30.50.3-0.6
Active lever presses in extinction session 60.20.21.4-0.2-0.30.20.1-0.30.4-0.40.40.50.3-0.51.20.5
Bone: final force3.25.06.32.42.3-2.4-2.42.4-2.52.4-2.4-2.3-2.22.0-1.6-1.9
Bone: final moment2.64.15.22.12.0-2.2-2.12.2-2.32.2-2.2-2.0-1.91.8-1.5-1.7
Food consumed during 24 hour testing period0.50.61.1-0.4-0.40.80.8-0.80.9-0.90.90.80.9-1.0-0.11.1
Glucose0.20.30.50.60.7-0.5-0.50.5-0.50.6-0.5-0.5-0.30.3-0.6-0.3
Heart weight5.48.313.63.73.5-3.3-3.33.3-2.92.9-2.8-2.6-2.31.9-2.7-1.6
Delay discount hyperbolic model param0.20.30.50.60.7-0.5-0.50.6-0.50.5-0.5-0.6-0.30.4-0.5-0.4
Intermittent access intake day 1-15 change0.40.81.20.70.9-0.8-0.80.9-0.90.8-0.8-1.1-0.81.0-0.8-1.0
Intermittent access intake escalation0.40.81.30.70.9-0.8-0.70.9-1.00.9-0.9-1.1-0.81.1-0.8-1.1
Intermittent access intake escalation 20.50.51.10.50.7-0.6-0.60.7-0.70.7-0.7-1.0-0.71.0-0.3-1.0
Intermitt. access day 1 inactive lever presses0.52.13.11.81.7-1.6-1.61.6-1.51.5-1.4-1.4-1.21.0-1.2-0.9
Intermitt. access day 15 inactive lever presses0.20.41.41.21.1-0.7-0.70.5-0.30.2-0.20.1-0.0-0.5-0.90.7
Intermitt. access escalation Index0.50.71.30.60.7-0.8-0.70.8-0.81.1-0.9-1.0-0.81.0-0.7-1.0
Intermittent access day 1 total infusions0.10.10.40.30.4-0.2-0.20.3-0.40.3-0.3-0.5-0.30.4-0.6-0.3
Intermittent access day 15 total infusions0.81.31.81.21.3-1.0-1.01.1-1.21.1-1.0-1.3-0.91.1-1.4-1.0
Intermittent access terminal intake (last 3 days)0.71.01.71.21.3-1.0-1.01.0-0.90.9-0.8-1.1-0.70.8-1.0-0.7
Intermittent access total infusions0.81.01.61.21.3-1.0-1.01.0-1.00.9-0.9-1.0-0.80.8-1.2-0.7
Intermittent access day 1 locomotion0.91.22.01.31.3-1.0-1.01.2-1.11.0-1.0-1.1-0.90.8-1.4-0.7
Intermittent access day 15 total locomotion0.30.51.41.11.2-0.9-1.00.9-0.50.3-0.3-0.6-0.30.20.0-0.2
Intermittent access total locomotion1.72.13.31.81.8-1.5-1.51.7-1.41.3-1.3-1.5-1.21.1-1.2-1.0
Intermittent access standard deviation0.40.71.31.01.1-0.8-0.80.8-0.90.8-0.8-1.0-0.60.8-1.1-0.7
Left kidney weight0.10.51.90.90.7-0.5-0.50.10.4-0.20.20.80.5-1.2-0.41.4
Right kidney weight0.10.51.80.90.7-0.4-0.40.20.3-0.20.10.70.4-1.1-0.71.3
Cocaine induced anxiety4.56.47.8-2.2-2.32.52.5-2.62.7-2.72.72.82.6-2.81.52.8
Post-drug Anxiety3.43.74.3-1.7-1.71.91.9-2.02.1-2.12.12.12.0-2.11.02.1
Baseline Anxiety0.30.40.60.50.6-0.5-0.50.6-0.60.6-0.6-0.7-0.60.7-0.6-0.8
Tail length3.714.416.63.93.7-3.8-3.83.8-4.04.1-4.0-3.6-3.93.4-4.0-3.2
Length with tail5.222.827.55.25.1-5.1-5.15.0-5.04.9-5.0-4.5-4.74.1-4.3-3.8
Length without tail1.65.17.92.82.8-2.7-2.72.5-2.22.2-2.2-2.0-2.11.6-1.6-1.4
Times rat made contact with spout0.10.10.1-0.2-0.10.20.2-0.20.3-0.30.30.20.2-0.3-0.20.3
Lifetime Intake0.80.91.61.21.3-1.0-1.01.0-1.00.9-0.9-1.0-0.70.7-1.3-0.6
Liver weight, left0.91.52.31.51.3-1.3-1.31.2-1.31.2-1.3-0.9-1.30.8-1.3-0.6
Liver weight, right0.20.30.70.70.8-0.6-0.60.5-0.50.4-0.5-0.5-0.50.4-0.3-0.4
Locomotor activity0.61.01.40.80.9-1.0-1.01.0-1.01.2-1.1-1.1-0.81.0-0.7-1.0
Locomotor testing distance0.00.00.10.20.2-0.2-0.20.1-0.00.2-0.20.00.2-0.2-0.10.2
Locomotor testing rearing0.40.81.31.21.2-1.1-1.21.1-0.70.9-0.9-0.7-0.50.3-0.5-0.2
Locomotion in novel chamber1.11.54.90.90.9-0.9-0.81.0-1.21.2-1.2-1.2-1.21.2-2.2-1.2
Locomotion in novel chamber post-restriction0.71.22.10.70.6-1.0-0.91.0-1.01.2-1.1-1.2-1.21.4-1.0-1.5
Fecal boli incidents, locomotor time 10.00.10.2-0.4-0.40.30.3-0.20.1-0.10.20.0-0.10.20.4-0.3
Change in fecal boli incidents, locomotor task0.10.10.2-0.3-0.30.20.2-0.20.4-0.30.30.30.5-0.30.10.3
Time >=10cm from walls, locomotor time 10.60.61.00.50.3-0.5-0.50.6-0.80.8-0.9-0.9-1.01.0-0.8-1.0
Bouts of movement, locomotor time 14.14.76.9-2.5-2.42.22.1-2.22.2-2.12.21.92.2-1.62.61.4
Total resting periods, locomotor time 13.64.05.7-2.4-2.42.12.0-2.02.1-2.02.11.72.0-1.42.31.2
Rest time, locomotor task time 10.30.40.8-0.9-0.90.80.8-0.80.6-0.50.60.60.6-0.40.20.3
Distance moved, locomotor task time 10.00.00.00.00.1-0.0-0.00.1-0.0-0.1-0.0-0.10.0-0.0-0.00.0
Vertical activity count, locomotor time 10.10.20.40.70.5-0.5-0.50.6-0.50.4-0.5-0.4-0.40.2-0.6-0.2
Time >=10cm from walls, locomotor time 20.20.30.50.50.3-0.3-0.20.3-0.60.6-0.7-0.5-0.70.5-0.6-0.4
Bouts of movement, locomotor time 20.20.30.9-1.0-0.90.80.9-0.70.5-0.30.40.30.3-0.00.1-0.1
Total resting periods, locomotor time 20.10.30.9-0.9-0.80.70.8-0.60.3-0.20.30.10.20.2-0.0-0.3
Rest time, locomotor task time 20.20.30.9-0.9-0.70.60.5-0.40.5-0.40.50.30.50.00.7-0.2
Distance moved, locomotor task time 20.10.10.60.1-0.00.10.1-0.30.3-0.40.20.50.3-0.70.30.7
Vertical activity count, locomotor time 20.10.10.30.60.4-0.3-0.30.2-0.20.1-0.20.1-0.2-0.30.30.4
Light reinforcement 10.41.11.61.00.9-1.1-1.01.1-1.21.2-1.1-0.8-1.31.0-0.6-0.9
Light reinforcement 20.20.40.50.70.7-0.6-0.60.7-0.70.5-0.6-0.5-0.70.6-0.6-0.5
Bone: marrow area1.12.46.31.91.5-1.5-1.41.4-1.61.7-1.7-1.1-1.50.9-2.5-0.7
Bone: maximum diameter3.87.19.23.02.8-3.0-3.02.9-2.82.8-2.8-2.5-2.72.2-1.8-2.0
Bone: maximum force0.81.31.81.31.2-1.3-1.31.2-1.31.2-1.2-1.1-1.00.9-0.8-0.8
Bone: maximum moment0.40.71.01.00.9-1.0-1.00.9-0.90.9-0.9-0.8-0.70.6-0.8-0.5
Mean time between licks in bursts0.00.10.4-0.7-0.60.40.4-0.40.1-0.10.10.30.00.0-0.1-0.1
Mean num. licks in bursts0.61.06.0-0.5-0.70.30.2-0.41.1-1.11.10.60.9-0.92.50.8
Cd content in liver2.93.23.91.71.9-1.7-1.72.0-1.91.8-1.8-2.0-1.71.8-1.4-1.8
Co content in liver2.83.34.01.61.8-1.7-1.71.8-2.01.9-2.0-2.0-2.01.9-1.2-1.9
Cu content in liver3.33.94.51.92.0-2.0-2.02.0-2.12.1-2.0-2.1-2.02.1-1.0-2.0
Fe content in liver0.30.40.60.50.5-0.6-0.60.6-0.70.8-0.7-0.5-0.80.7-0.6-0.7
K content in liver0.50.50.70.70.8-0.8-0.90.8-0.70.8-0.7-0.8-0.70.6-0.0-0.6
Mg content in liver3.13.23.71.61.7-1.9-1.91.8-1.81.9-1.9-1.9-1.91.9-0.8-1.8
Mn content in liver3.13.44.21.91.8-2.0-2.02.0-2.02.0-2.0-1.9-1.91.7-1.0-1.7
Na content in liver0.30.40.7-0.4-0.60.50.5-0.60.6-0.50.60.70.6-0.80.20.8
Rb content in liver3.03.54.91.92.2-2.1-2.12.1-1.91.8-1.8-2.0-1.71.8-0.4-1.8
Se content in liver1.82.12.71.61.6-1.6-1.61.5-1.61.6-1.5-1.4-1.31.3-0.6-1.2
Sr content in liver1.41.24.11.10.9-0.9-0.81.0-1.21.2-1.2-0.9-1.10.9-2.0-0.7
Zn content in liver1.01.11.90.91.1-1.1-1.11.0-1.01.1-1.0-1.4-0.91.20.1-1.2
Bone: minimum diameter1.42.53.01.61.5-1.7-1.71.6-1.71.7-1.7-1.6-1.61.3-1.2-1.3
Time in familiar zone, hab. session 10.40.40.7-0.8-0.80.80.9-0.80.5-0.50.50.60.5-0.50.10.5
Time in novel zone, hab. session 10.20.20.70.80.8-0.6-0.70.5-0.10.1-0.1-0.1-0.2-0.0-0.00.1
Total zone transitions, hab. session 10.60.81.41.21.1-1.1-1.20.9-0.90.9-0.9-0.6-1.00.5-0.5-0.4
Total locomotion distance, hab. session 10.40.61.51.21.1-1.1-1.10.7-0.70.7-0.7-0.2-0.7-0.1-0.70.2
Locomotion velocity, hab. session 10.50.71.71.31.1-1.1-1.20.8-0.80.8-0.8-0.4-0.70.0-0.70.1
Time in familiar zone, hab. session 21.11.21.5-1.0-1.01.11.1-1.11.2-1.21.21.11.1-1.11.01.0
Time in novel zone, hab. session 21.21.21.60.91.0-1.0-1.01.1-1.31.3-1.3-1.1-1.21.1-1.1-1.0
Total zone transitions, hab. session 22.93.74.51.91.9-2.1-2.11.9-2.12.1-2.1-1.9-2.11.9-1.0-1.8
Total locomotion distance, hab. session 20.81.12.81.71.6-1.5-1.61.1-0.80.8-0.8-0.6-0.70.2-0.0-0.1
Locomotion velocity, hab. session 20.40.61.81.31.3-1.2-1.20.8-0.40.4-0.4-0.2-0.3-0.20.40.3
Novel to familiar place preference ratio0.10.10.5-0.00.10.20.2-0.30.3-0.30.30.40.3-0.6-0.10.7
Novelty place preference0.20.20.6-0.3-0.20.40.5-0.50.5-0.50.50.60.5-0.7-0.10.8
Time in novel zone, NPP test0.10.10.5-0.1-0.00.30.3-0.40.4-0.40.40.40.4-0.6-0.10.7
Total zone transitions, NPP test0.60.91.21.00.9-1.0-1.00.8-1.11.1-1.1-0.8-1.10.8-0.9-0.8
Total locomotion distance, NPP test0.91.23.31.81.6-1.4-1.41.1-0.90.9-0.9-0.5-0.70.1-1.00.1
Locomotion velocity, NPP test0.50.72.21.51.2-1.1-1.10.8-0.60.6-0.6-0.2-0.5-0.2-0.80.3
Intraocular pressure0.30.41.00.30.1-0.3-0.20.3-0.60.8-0.7-0.5-0.80.7-1.0-0.7
Delta distance traveled before/after self-admin0.10.20.4-0.6-0.60.50.6-0.40.2-0.30.20.00.00.2-0.6-0.2
Delta ambulatory time before/after self-admin1.82.23.9-2.0-1.91.91.9-1.71.5-1.51.41.31.2-1.00.60.8
Parametrial fat weight0.20.40.9-0.9-0.60.90.9-0.70.4-0.60.70.40.5-0.3-0.40.2
Pavlov. Cond. lever latency0.20.30.70.0-0.0-0.2-0.10.3-0.60.6-0.6-0.5-0.70.8-0.8-0.8
Pavlov. Cond. magazine entry latency0.30.41.00.81.0-0.8-0.80.6-0.50.5-0.5-0.5-0.40.30.4-0.3
Pavlov. Cond. change in total contacts0.10.10.40.60.7-0.4-0.40.3-0.20.1-0.1-0.1-0.1-0.1-0.00.1
Pavlov. Cond. index score0.10.10.60.30.4-0.2-0.20.00.2-0.20.20.10.3-0.30.80.3
Pavlov. Cond. latency score0.20.31.10.20.3-0.0-0.1-0.20.5-0.50.50.40.6-0.61.10.7
Pavlov. Cond. lever contacts0.10.20.60.30.3-0.1-0.2-0.00.3-0.40.40.20.5-0.50.80.5
Pavlov. Cond. magazine entry number0.40.50.9-0.7-0.90.70.7-0.60.8-0.70.70.80.6-0.7-0.00.7
Pavlov. Cond. intertrial magazine entries0.40.40.60.60.6-0.6-0.60.8-0.70.6-0.7-0.7-0.60.6-0.8-0.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.30.4-0.2-0.20.00.1-0.20.20.00.3-0.20.70.2
Pavlov. Cond. response bias0.40.51.00.81.0-0.8-0.80.7-0.70.7-0.7-0.7-0.50.6-0.1-0.6
Pavlov. Cond. lever latency3.34.45.2-2.2-2.32.22.2-2.22.2-2.22.22.12.1-2.01.01.9
Pavlov. Cond. magazine entry latency0.00.00.10.20.0-0.0-0.0-0.00.1-0.00.00.20.1-0.3-0.00.3
Pavlov. Cond. change in total contacts1.52.42.81.51.3-1.6-1.61.6-1.71.7-1.7-1.6-1.61.6-0.6-1.5
Pavlov. Cond. index score1.92.63.11.71.6-1.7-1.71.7-1.71.8-1.8-1.6-1.61.5-0.8-1.5
Pavlov. Cond. latency score1.31.82.11.51.3-1.4-1.41.4-1.41.5-1.5-1.3-1.31.2-0.6-1.2
Pavlov. Cond. lever contacts2.83.94.62.12.2-2.1-2.12.0-2.12.1-2.1-1.9-2.01.8-1.1-1.7
Pavlov. Cond. magazine entry number0.60.70.9-0.9-0.80.80.8-0.90.9-1.01.00.90.8-0.80.60.8
Pavlov. Cond. intertrial magazine entries0.10.10.90.1-0.10.20.2-0.30.2-0.20.20.40.1-0.4-1.00.4
Pavlov. Cond. lever-magazine prob. diff.1.41.92.21.41.3-1.5-1.51.4-1.51.5-1.5-1.4-1.41.3-0.5-1.3
Pavlov. Cond. response bias3.04.15.02.22.2-2.2-2.12.1-2.22.2-2.2-2.0-2.01.9-1.2-1.8
Time in closed arm before self-admin0.60.71.3-1.1-1.11.11.1-1.10.8-0.70.70.80.6-0.50.70.5
Time in closed arm after self-admin1.21.32.7-1.6-1.71.51.5-1.51.0-0.70.90.90.8-0.60.30.5
Time in open arm before self-admin0.20.21.40.10.1-0.1-0.10.2-0.40.2-0.3-0.4-0.30.4-1.2-0.5
Time in open arm after self-admin0.60.71.81.31.3-1.1-1.21.1-0.70.4-0.6-0.6-0.40.3-0.3-0.2
Bone: periosteal estimation2.45.06.12.52.2-2.3-2.32.3-2.52.5-2.5-2.1-2.21.8-2.2-1.7
Bone: periosteal perimeter2.13.75.82.42.3-2.3-2.32.1-2.01.9-1.9-1.7-1.71.4-1.2-1.3
Bone: post-yield work0.81.21.6-1.0-1.11.11.1-1.21.1-1.11.11.21.2-1.20.31.3
Progressive ratio test 1 active lever presses2.83.54.22.02.0-1.9-1.92.0-1.91.8-1.8-1.9-1.81.7-1.8-1.7
Progressive ratio test 1 breakpoint3.13.84.52.02.1-2.0-2.02.1-2.01.9-1.9-2.0-1.81.8-1.8-1.7
Progressive ratio test 1 inactive lever presses0.71.01.61.21.3-1.2-1.21.2-1.00.9-0.8-0.9-0.80.7-0.7-0.7
Progressive ratio test 2 active lever presses0.60.71.11.01.0-0.9-0.90.9-0.80.8-0.7-0.8-0.70.6-0.7-0.6
Progressive ratio test 2 breakpoint0.70.81.31.11.1-1.0-1.01.0-0.90.8-0.8-0.9-0.80.7-0.7-0.7
Progressive ratio test 2 inactive lever presses1.22.03.92.01.9-1.7-1.71.6-1.41.2-1.2-1.2-1.10.8-1.2-0.6
Incentive Sensitization - Responses0.00.00.2-0.1-0.1-0.1-0.10.1-0.10.00.0-0.1-0.20.10.4-0.1
Incentive Sensitization - Breakpoint0.00.00.2-0.2-0.20.10.1-0.10.1-0.20.20.10.0-0.10.50.1
Sum of active levers in priming session hrs 5-60.20.20.70.80.6-0.6-0.60.7-0.50.2-0.3-0.3-0.30.00.10.0
Progressive ratio5.89.010.3-3.1-3.23.23.2-3.13.1-3.23.13.03.1-2.92.02.8
Food seeking constrained by brief footshock0.20.20.60.50.4-0.3-0.40.20.2-0.30.20.30.3-0.70.60.8
Seeking ratio, punishment vs. effort4.26.18.32.82.8-2.9-2.92.8-2.52.5-2.5-2.3-2.42.0-1.0-1.9
Retroperitoneal fat weight0.31.11.8-0.8-0.81.21.2-1.11.0-0.91.01.41.0-1.2-0.61.3
Reaction time number correct0.00.00.10.30.1-0.2-0.20.00.10.10.00.10.0-0.30.10.3
Reaction time mean minus median0.61.51.9-1.1-1.11.21.2-1.31.3-1.41.21.31.4-1.30.51.3
Reaction time mean minus median AUC0.30.61.0-0.6-0.60.70.7-0.80.9-0.90.90.81.0-0.90.40.9
Reaction time num false alarms1.82.64.52.02.1-2.0-2.01.7-1.51.7-1.7-1.4-1.51.1-0.6-1.0
Reaction time num false alarms AUC1.52.43.61.71.9-1.9-1.91.6-1.51.6-1.7-1.4-1.51.2-0.5-1.1
Reaction time trials correct on left0.00.00.10.30.1-0.2-0.20.00.10.10.00.10.0-0.30.10.3
Reaction time trials on left0.00.00.10.40.1-0.3-0.30.10.00.1-0.10.0-0.0-0.20.10.3
Reaction time mean0.00.10.30.20.2-0.2-0.20.2-0.20.2-0.3-0.2-0.10.2-0.5-0.2
Reaction time mean AUC0.00.00.20.10.2-0.1-0.10.2-0.20.2-0.2-0.1-0.10.2-0.5-0.2
Median of all reaction times0.20.30.50.50.5-0.5-0.50.5-0.60.6-0.6-0.5-0.50.5-0.7-0.5
Reaction time omissions0.60.81.71.11.2-1.2-1.31.1-0.70.6-0.7-0.8-0.70.70.2-0.7
Reaction time false alarm rate1.21.72.71.41.6-1.5-1.61.4-1.21.3-1.4-1.2-1.21.1-0.3-1.0
Reaction time premature initiation rate0.30.51.70.40.3-0.4-0.30.4-0.80.7-0.8-0.5-0.90.7-1.3-0.6
Reaction time premature initiations0.10.10.70.30.1-0.2-0.10.1-0.40.4-0.4-0.2-0.60.2-0.8-0.2
Std. dev. reaction times0.10.20.40.30.4-0.4-0.40.4-0.40.3-0.5-0.4-0.30.4-0.6-0.4
Reaction time trials completed0.00.00.10.40.1-0.3-0.30.10.00.1-0.10.0-0.0-0.20.10.3
Reaction time trials AUC0.00.00.10.30.1-0.2-0.20.10.10.1-0.00.0-0.0-0.20.10.3
Run reversals in cocaine runway, females0.50.51.51.01.0-0.7-0.70.7-0.70.6-0.7-0.6-0.50.4-1.2-0.3
Run reversals in cocaine runway, males1.71.72.51.31.4-1.5-1.61.4-1.21.3-1.3-1.2-1.31.20.5-1.2
Latency to leave start box in cocaine runway1.21.32.0-1.3-1.41.11.1-1.31.3-1.01.11.01.0-0.91.40.8
Latency to leave start box in cocaine runway, F2.52.94.8-2.2-2.11.81.7-1.91.9-1.41.51.31.3-1.02.10.8
Latency to leave start box in cocaine runway, M0.20.20.50.60.4-0.4-0.40.4-0.40.4-0.3-0.1-0.30.1-0.70.0
Std. dev. time between licks in bursts0.91.32.61.11.2-1.1-1.01.0-1.21.2-1.2-1.0-1.10.9-1.6-0.9
Total sessions with >9 infusions0.20.30.50.50.6-0.4-0.40.6-0.60.3-0.4-0.7-0.40.6-0.7-0.6
Short access day 1 total inactive lever presses0.10.10.50.50.4-0.1-0.10.1-0.0-0.1-0.0-0.00.2-0.3-0.70.4
Short access day 10 total inactive lever presses0.20.61.1-0.5-0.70.70.7-0.80.7-0.70.70.80.8-1.00.21.0
Short access day 1 total infusions0.10.10.30.40.4-0.3-0.30.2-0.10.1-0.1-0.10.0-0.1-0.60.2
Short access day 10 total infusions0.10.10.60.20.2-0.1-0.10.2-0.20.2-0.2-0.3-0.20.2-0.8-0.2
Short access total infusions0.30.41.50.60.7-0.5-0.50.6-0.60.5-0.5-0.6-0.40.5-1.2-0.4
Short access day 1 locomotion0.10.10.30.30.3-0.0-0.0-0.00.1-0.20.20.10.3-0.4-0.30.5
Short access day 10 total locomotion0.30.61.21.11.0-0.9-0.91.0-0.70.7-0.6-0.7-0.50.5-0.3-0.4
Short access total locomotion0.50.61.21.11.1-0.9-0.90.9-0.60.6-0.6-0.7-0.40.4-0.8-0.3
One hour access (0.3 mA shock)0.30.40.60.60.8-0.7-0.70.7-0.60.6-0.5-0.7-0.50.6-0.3-0.5
Compulsive drug intake0.20.20.3-0.5-0.50.50.5-0.60.5-0.40.50.60.4-0.50.50.5
One hour access (shock baseline)0.20.30.50.50.6-0.5-0.50.6-0.50.5-0.5-0.7-0.40.6-0.3-0.6
Social response proportion0.20.20.50.70.6-0.7-0.70.6-0.30.3-0.3-0.3-0.30.10.1-0.1
Social responses1.92.43.51.61.3-1.8-1.81.9-1.61.6-1.6-1.6-1.61.50.1-1.6
Social time0.10.20.70.30.1-0.5-0.60.3-0.30.3-0.3-0.4-0.40.50.8-0.5
Soleus weight0.20.62.21.10.8-0.8-0.70.6-0.70.6-0.7-0.3-0.60.2-1.5-0.0
Bone: stiffness1.21.92.91.61.5-1.7-1.71.5-1.51.4-1.4-1.3-1.31.1-0.2-1.0
Tibialis anterior weight1.75.86.92.42.4-2.4-2.42.4-2.62.6-2.6-2.4-2.42.3-2.2-2.2
Time to tail flick, vehicle, before self-admin0.70.71.7-0.4-0.30.80.8-0.90.9-0.70.60.91.1-1.2-0.31.3
Time to tail flick, vehicle, after self-admin0.40.51.2-0.8-0.91.01.1-0.90.5-0.40.60.70.6-0.5-0.50.5
Time to tail flick, test, before self-admin0.90.91.80.60.7-0.8-0.80.9-1.10.7-0.9-1.2-1.11.3-0.7-1.3
Time to tail flick, test, after self-admin0.70.71.6-0.7-0.60.60.6-0.71.0-0.90.91.00.9-1.01.31.0
Delta time to tail flick, vehicle, before/after SA1.31.31.80.90.7-1.0-1.01.1-1.21.3-1.1-1.2-1.31.3-0.9-1.3
Delta time to tail flick, test, before/after SA1.11.22.4-0.6-0.60.80.8-1.01.2-0.90.91.41.2-1.51.01.6
Tibia length4.211.515.42.62.4-3.0-3.03.3-3.93.9-3.8-3.7-3.73.9-2.4-3.9
Ambulatory time before self-admin2.84.25.22.32.3-2.2-2.22.1-2.12.1-2.1-1.9-1.91.7-2.0-1.6
Ambulatory time after self-admin1.51.73.01.11.1-1.1-1.11.2-1.31.4-1.4-1.3-1.31.4-1.7-1.4
Bone: tissue strength0.10.10.40.50.6-0.4-0.40.4-0.20.1-0.1-0.10.0-0.1-0.00.2
Total heroin consumption0.91.02.11.31.1-1.4-1.51.3-1.00.8-0.8-0.9-0.90.70.4-0.7
Bone: trabecular number2.84.77.02.62.3-2.3-2.32.4-2.32.2-2.2-2.0-2.01.6-2.1-1.5
Bone: trabecular spacing0.60.82.5-1.0-0.60.80.8-1.01.0-0.90.90.80.8-0.61.60.6
Bone: trabecular thickness0.81.01.71.21.2-1.2-1.21.3-1.00.9-0.9-1.0-0.90.7-0.5-0.7
Bone: trabecular tissue density1.01.42.61.41.6-1.5-1.61.4-1.11.0-1.0-1.1-0.91.00.3-0.9
Water consumed over 24 hours0.10.11.00.20.20.00.10.2-0.20.2-0.2-0.4-0.10.2-1.0-0.2
Number of responses in last shaping day0.20.30.60.60.6-0.5-0.50.5-0.40.6-0.6-0.5-0.40.4-0.8-0.3