Vezt

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Vezt 0.29 0.1 0.0e+00 0.29 0.3 0.3 0.31 1.0e-15 1.7e-16 1.2e-16 3.5e-17
2 IL mRNA stability Vezt 0.26 0.12 2.8e-04 0.08 0.08 0.03 0.08 6.0e-03 6.0e-03 5.8e-02 5.4e-03
3 NAcc gene expression Vezt 0.07 0.03 1.3e-13 0.11 0.12 0.12 0.12 6.6e-13 2.9e-14 6.5e-14 3.7e-14
4 NAcc mRNA stability Vezt 0.12 0.04 0.0e+00 0.17 0.2 0.2 0.2 1.7e-19 1.2e-22 4.8e-23 3.0e-23
5 BLA mRNA stability Vezt 0.27 0.1 0.0e+00 0.29 0.33 0.33 0.33 4.1e-16 3.7e-18 1.5e-18 2.0e-18
6 Adipose mRNA stability Vezt 0.07 0.03 8.4e-12 0.07 0.09 0.08 0.09 1.2e-08 3.0e-10 7.9e-09 8.7e-10
7 OFC mRNA stability Vezt 0.37 0.15 1.3e-04 0.22 0.13 0.18 0.2 4.6e-06 4.6e-04 3.8e-05 1.7e-05
8 PL gene expression Vezt 0.26 0.07 0.0e+00 0.33 0.36 0.36 0.36 5.3e-37 6.7e-41 1.3e-40 2.7e-41
9 PL mRNA stability Vezt 0.16 0.06 0.0e+00 0.21 0.2 0.21 0.22 2.2e-22 5.2e-22 9.5e-23 2.5e-23
10 Brain intron excision ratio chr7_28536176_28538306 0.04 0.03 5.1e-03 0.01 0.03 0.02 0.02 4.7e-02 1.3e-03 4.3e-03 7.7e-03
11 IL gene expression Vezt 0.31 0.13 2.1e-05 0.13 0.17 0.13 0.15 5.8e-04 6.6e-05 5.8e-04 1.7e-04
12 pVTA gene expression Vezt 0.1 0.06 1.7e-03 0.04 0.04 0.02 0.02 4.9e-03 5.5e-03 5.4e-02 3.5e-02
13 Brain gene expression Vezt 0.2 0.07 0.0e+00 0.21 0.22 0.22 0.22 1.9e-19 2.2e-20 4.1e-20 2.4e-20
14 Brain mRNA stability Vezt 0.08 0.04 3.4e-06 0.06 0.06 0.07 0.06 5.3e-06 1.5e-06 4.3e-07 1.7e-06
15 NAcc intron excision ratio chr7_28538513_28538938 0.04 0.03 2.2e-04 0.02 0.03 0.03 0.03 1.2e-03 1.6e-04 1.5e-04 1.2e-04
16 OFC gene expression Vezt 0.26 0.12 8.1e-05 0.18 0.17 0.13 0.15 4.2e-05 6.7e-05 6.1e-04 2.5e-04
17 NAcc alternative polyA XM_039078694.1 0.02 0.01 7.3e-03 0.01 0.01 0 0.01 2.7e-02 2.8e-02 2.2e-01 6.2e-02
18 NAcc alternative polyA XM_039078694.1 0.02 0.01 6.8e-03 0.01 0.01 0 0.01 2.1e-02 2.6e-02 8.8e-02 3.8e-02
19 Adipose gene expression Vezt 0.11 0.05 3.4e-12 0.1 0.09 0.09 0.09 8.4e-11 1.1e-09 8.5e-10 2.1e-10
20 Liver gene expression Vezt 0.14 0.06 0.0e+00 0.1 0.15 0.15 0.13 3.5e-11 4.7e-16 2.1e-16 1.4e-14
21 BLA intron excision ratio chr7_28557619_28560958 0.12 0.09 4.2e-03 0.02 0.03 0.03 0.03 4.3e-02 6.0e-03 7.1e-03 8.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.10.11.0-0.10.10.0-0.3-0.30.6-0.40.30.2-0.40.1-0.0-0.00.00.00.30.60.6-0.3-1.00.1
Area under the delay curve0.30.32.0-0.4-0.4-0.3-0.40.0-0.7-0.2-0.5-0.2-0.20.0-0.1-0.50.2-0.20.2-0.9-0.90.11.40.0
BMI with tail2.16.710.1-3.0-2.3-2.7-3.22.8-2.12.7-2.5-2.92.5-2.33.2-2.93.2-3.23.0-2.2-2.22.20.41.5
BMI without tail5.411.217.8-3.1-3.3-3.6-3.93.2-2.93.4-3.3-3.73.7-3.33.8-3.73.4-3.94.2-2.8-2.83.11.72.8
Body weight14.962.382.0-8.5-8.1-8.6-9.18.4-7.27.7-8.1-8.58.3-7.88.9-8.28.0-9.08.3-6.9-6.96.35.06.4
Weight adjusted by age0.60.73.3-0.6-0.4-0.7-0.60.7-0.9-0.0-0.9-0.61.0-0.90.5-0.90.7-0.21.4-0.8-0.81.80.40.1
Bone surface0.10.20.6-0.6-0.3-0.5-0.80.2-0.50.5-0.2-0.10.1-0.10.4-0.40.4-0.30.7-0.1-0.10.20.20.4
Bone volume0.20.41.3-0.8-0.6-0.7-1.10.5-0.30.3-0.4-0.50.3-0.50.8-0.80.8-0.71.1-0.2-0.20.4-0.30.6
Breakpoint value in progressive ratio session1.01.13.31.01.51.31.0-1.01.0-1.40.60.7-1.41.4-0.80.5-0.30.8-0.70.60.6-0.5-1.5-1.8
Number of licking bursts0.20.30.8-0.0-0.00.1-0.1-0.50.20.80.50.6-0.70.6-0.40.5-0.10.6-0.30.90.9-0.4-0.8-0.5
Context. condit. distance diff. score1.21.42.9-1.0-1.2-1.2-1.01.2-1.40.8-1.3-1.11.3-1.40.9-1.10.8-0.61.0-1.4-1.41.31.71.2
Locomotion velocity, session 10.40.41.70.50.80.80.8-0.30.4-1.10.40.4-0.50.8-0.30.6-0.50.4-0.70.20.2-0.2-0.7-1.3
Locomotion distance, session 10.20.21.0-0.5-0.2-0.1-0.00.6-0.6-0.2-0.5-0.6-0.00.20.3-0.20.3-0.3-0.2-0.7-0.70.30.2-1.0
Locomotion velocity, session 20.10.10.50.50.00.30.1-0.10.7-0.60.2-0.20.3-0.20.2-0.1-0.1-0.50.30.20.2-0.2-0.70.2
Locomotion distance, session 20.50.71.5-1.1-0.6-0.8-0.81.1-0.90.6-1.1-1.20.6-0.50.8-0.90.9-1.20.5-1.0-1.00.50.3-0.2
Locomotion velocity, session 30.60.71.4-0.7-0.1-0.4-0.21.0-0.6-0.9-0.8-0.91.1-1.00.8-0.81.0-0.70.8-1.1-1.11.20.10.6
Locomotion distance, session 31.31.42.1-1.3-0.6-1.0-0.91.5-1.30.4-1.4-1.41.2-1.11.3-1.31.4-1.11.1-1.4-1.41.30.90.5
Stereotopy head waving bouts, day 31.61.92.51.21.21.41.3-1.31.4-1.11.61.3-1.61.6-1.11.5-1.31.0-1.51.41.4-1.6-1.4-1.4
Stereotopy head waving duration, day 30.50.61.20.60.30.80.8-0.61.0-1.10.80.6-0.70.7-0.60.8-0.60.3-0.80.70.7-1.0-1.1-0.5
Locomotion velocity, session 70.91.03.0-0.5-1.0-0.8-0.81.1-0.80.4-1.1-1.11.7-1.20.9-0.90.6-1.11.5-0.9-0.91.7-0.10.2
Locomotion distance, session 70.30.41.1-0.6-0.5-0.5-0.40.8-0.6-0.0-0.8-0.81.0-0.80.5-0.60.4-0.60.8-0.7-0.71.00.20.2
Stereotopy head waving bouts, day 70.20.22.5-0.0-0.10.10.10.10.8-0.3-0.1-0.20.3-0.30.3-0.10.4-0.60.10.30.3-0.2-1.60.3
Stereotopy head waving duration, day 70.20.32.60.10.20.40.4-0.30.9-0.50.30.2-0.20.2-0.10.20.1-0.2-0.10.60.6-0.5-1.6-0.1
Locomotion velocity, session 80.91.12.0-0.7-0.6-0.9-0.91.1-0.8-0.1-1.2-1.31.2-1.31.0-1.31.2-0.91.1-1.4-1.41.20.70.8
Locomotion distance, session 84.56.79.6-2.7-2.3-2.7-2.42.9-3.01.8-3.0-2.92.6-2.62.1-2.72.4-2.12.2-3.1-3.12.72.71.5
Degree of sensitization distance0.30.30.60.60.10.50.5-0.60.7-0.50.50.6-0.40.3-0.80.5-0.70.6-0.30.70.7-0.5-0.8-0.1
Degree of sensitization stereotypy0.30.33.40.30.50.40.5-0.31.2-0.50.30.1-0.0-0.1-0.00.20.2-0.1-0.20.70.7-0.4-1.90.3
Conditioned locomotion0.10.10.60.1-0.6-0.1-0.30.3-0.00.0-0.1-0.30.7-0.20.50.3-0.7-0.80.20.10.10.20.3-0.2
Cocaine response after cond. corrected0.20.21.0-0.3-0.5-0.4-0.60.00.00.3-0.2-0.30.0-0.30.2-0.3-0.0-0.70.10.00.0-0.70.51.0
Cocaine response after cond. not corrected0.20.21.0-0.5-0.4-0.5-0.60.1-0.40.3-0.4-0.4-0.1-0.20.1-0.40.0-0.60.2-0.3-0.3-0.41.00.8
Cocaine response before conditioning0.20.20.7-0.10.60.10.4-0.2-0.6-0.1-0.30.0-0.50.3-0.5-0.00.10.5-0.3-0.4-0.40.70.8-0.6
Saline control response0.50.73.8-0.7-0.5-0.9-0.80.5-0.21.1-0.5-0.71.3-1.20.4-0.60.3-1.31.0-0.1-0.10.40.02.0
Bone: connectivity density0.71.11.70.81.10.90.7-1.31.1-0.81.21.2-1.31.1-1.00.8-1.01.1-0.51.31.3-1.0-1.3-0.5
Bone: cortical apparent density0.91.13.4-0.5-1.1-0.9-0.91.2-1.31.0-1.0-1.11.4-0.91.0-1.00.5-0.91.3-1.1-1.11.81.10.1
Bone: cortical area1.92.94.8-2.0-2.2-1.8-2.11.8-1.91.1-1.6-1.81.3-1.31.9-1.72.0-1.81.6-1.8-1.80.91.61.0
Bone: cortical porosity0.30.41.8-0.1-0.5-0.3-0.40.40.5-0.4-0.4-0.70.6-0.60.7-0.60.7-1.40.3-0.2-0.2-0.8-0.31.1
Bone: cortical porosity0.60.62.7-0.5-0.7-0.6-0.70.8-0.0-0.2-0.8-1.10.8-0.71.0-0.81.0-1.60.5-0.7-0.7-0.50.10.8
Bone: cortical thickness1.32.23.9-1.5-2.0-1.5-1.71.6-1.30.5-1.3-1.61.4-1.31.8-1.41.4-2.01.3-1.6-1.60.51.41.3
Bone: cortical thickness0.30.41.10.80.40.70.3-0.40.8-0.90.80.3-0.50.80.20.5-0.5-0.2-0.20.70.7-1.1-0.7-0.7
Bone: cortical tissue density0.91.13.6-0.5-1.0-0.9-0.81.1-1.31.0-1.0-1.11.4-0.91.0-1.00.5-0.91.3-1.1-1.11.91.10.1
Condit. Reinf. active minus inactive responses1.61.84.11.51.81.61.7-1.41.0-1.41.31.3-1.71.5-1.41.1-0.82.0-1.30.70.7-0.3-0.6-1.6
Condit. Reinf. active-inactive response ratio1.31.42.81.21.31.31.3-1.31.2-1.31.11.1-1.71.3-1.11.0-0.71.5-1.40.80.8-1.0-1.0-1.2
Condit. Reinf. active responses3.54.36.22.42.42.42.4-2.31.8-1.82.32.1-2.42.3-2.11.9-1.62.5-1.91.71.7-1.2-1.3-2.2
Condit. Reinf. inactive responses2.42.84.32.11.91.91.9-1.91.7-1.21.91.7-1.71.9-1.61.6-1.41.6-1.41.71.7-1.3-1.4-1.6
Incentive salience index mean0.50.62.00.81.00.91.0-0.80.3-0.70.70.7-1.21.0-0.80.5-0.11.4-0.70.20.20.1-0.2-1.4
Condit. Reinf. lever presses0.10.10.9-0.10.0-0.1-0.10.1-0.40.1-0.3-0.3-0.30.20.1-0.40.80.20.3-0.4-0.40.60.3-1.0
Condit. Reinf. active minus inactive responses0.20.22.20.40.50.50.4-0.20.8-0.90.1-0.2-0.30.10.2-0.30.40.20.10.10.10.4-1.5-0.5
Condit. Reinf. active-inactive response ratio0.20.21.1-0.30.2-0.1-0.20.10.5-0.5-0.1-0.2-0.0-0.50.4-0.60.80.30.3-0.2-0.20.2-1.00.7
Condit. Reinf. active responses0.20.21.50.50.40.50.4-0.10.5-0.70.2-0.2-0.20.30.2-0.10.1-0.00.10.00.00.5-1.2-0.9
Condit. Reinf. inactive responses0.60.74.11.30.71.11.0-0.60.3-0.80.50.3-0.61.2-0.40.7-1.00.2-0.40.40.40.1-0.1-2.0
Condit. Reinf. lever presses0.40.52.70.1-0.4-0.0-0.30.40.6-0.2-0.3-0.80.7-0.41.0-0.80.8-1.01.2-0.1-0.10.6-1.7-0.4
Condit. Reinf. lever reinforcers received0.10.21.10.30.20.40.30.10.2-0.6-0.0-0.4-0.10.20.3-0.30.3-0.10.2-0.2-0.20.8-1.0-1.0
Conditioned reinforcement - actives0.30.31.7-0.6-1.3-0.7-0.50.0-0.41.20.00.3-0.0-0.5-0.1-0.10.10.7-0.10.50.5-0.10.41.0
Conditioned reinforcement - inactives0.10.21.4-0.3-0.6-0.3-0.4-0.0-0.21.2-0.1-0.0-0.50.20.5-0.10.30.1-0.40.20.2-0.40.3-0.0
Conditioned locomotion1.01.23.1-1.3-1.6-1.4-1.11.0-1.01.5-1.0-0.80.9-1.40.9-1.01.2-0.50.5-0.5-0.50.80.91.8
Patch foraging indifference point 0 sec0.20.41.60.50.10.40.3-0.70.5-0.10.60.9-0.10.4-1.00.7-1.30.20.01.01.0-0.20.0-0.2
Patch foraging indifference point AUC0.20.21.0-0.1-0.40.0-0.3-0.50.40.50.50.5-0.30.2-0.20.2-0.50.70.61.01.0-0.2-0.60.6
Delay disc. indifference point, 0s delay0.20.21.50.20.40.40.2-0.30.6-0.50.0-0.1-0.80.7-0.0-0.20.30.10.10.10.1-0.3-0.8-1.2
Delay disc. indifference point, 16s delay0.50.51.6-0.9-1.0-0.6-0.70.5-1.00.3-0.7-0.6-0.10.10.3-0.50.4-0.80.2-1.0-1.0-0.11.3-0.2
Delay disc. indifference point, 2s delay1.01.13.0-1.2-0.8-1.0-0.70.9-1.40.5-1.3-0.60.8-0.90.2-1.00.9-0.30.8-1.7-1.71.21.50.4
Delay disc. indifference point, 24s delay1.71.65.5-1.3-1.1-1.1-1.01.0-2.00.2-1.4-0.90.7-0.60.7-1.31.0-0.51.1-1.9-1.91.62.30.3
Delay disc. indifference point, 4s delay0.10.10.80.1-0.3-0.1-0.2-0.2-0.1-0.2-0.1-0.00.10.1-0.20.0-0.6-0.60.1-0.2-0.2-0.40.90.2
Delay disc. indifference point, 8s delay0.10.10.60.20.00.2-0.0-0.60.2-0.80.20.3-0.50.3-0.3-0.2-0.20.20.1-0.1-0.1-0.30.60.2
Indifference point function ln k0.10.20.50.00.2-0.2-0.30.5-0.6-0.0-0.3-0.40.3-0.10.5-0.40.3-0.40.3-0.7-0.70.50.6-0.6
Indifference point function log k0.10.20.50.00.2-0.2-0.30.5-0.6-0.0-0.3-0.40.3-0.10.5-0.40.3-0.40.3-0.7-0.70.50.6-0.6
Patch foraging total patch changes 0 sec0.20.41.70.60.10.40.3-0.70.5-0.10.60.9-0.00.4-0.90.7-1.30.10.11.01.0-0.1-0.0-0.2
Patch foraging total patch changes 12 sec0.30.41.4-0.7-1.2-0.6-0.90.1-0.00.8-0.1-0.10.6-0.50.5-0.2-0.2-0.41.20.50.50.3-0.00.9
Patch foraging total patch changes 18 sec0.40.51.40.1-0.4-0.1-0.2-0.80.51.20.40.9-0.3-0.0-0.80.5-0.90.80.01.21.2-0.40.10.9
Patch foraging total patch changes 24 sec0.50.62.8-0.8-1.2-1.0-1.10.3-0.41.3-0.4-0.30.9-0.90.5-0.50.1-0.61.10.10.10.20.61.7
Patch foraging total patch changes 6 sec0.60.92.50.60.20.60.4-1.20.80.21.21.3-0.70.8-1.21.0-1.50.90.11.61.6-0.4-0.7-0.2
Patch foraging time to switch 0 sec0.10.21.20.1-0.4-0.10.10.30.30.1-0.3-0.40.4-0.40.30.10.1-1.1-0.5-0.1-0.1-0.90.20.5
Patch foraging water rate 0 sec1.11.85.1-1.7-1.3-1.5-1.71.3-2.21.8-1.0-1.01.0-0.81.0-1.20.8-0.31.4-1.2-1.22.31.40.2
Patch foraging water rate 12 sec1.82.85.1-2.1-1.9-2.2-2.21.7-1.22.3-1.3-1.41.7-2.01.7-1.51.4-1.71.8-0.8-0.81.30.52.1
Patch foraging water rate 18 sec0.10.10.8-0.40.2-0.1-0.1-0.00.00.30.30.3-0.2-0.0-0.10.20.10.3-0.20.30.30.2-0.90.2
Patch foraging water rate 24 sec4.76.59.8-2.9-3.0-2.9-2.62.9-3.12.5-2.6-2.52.1-2.42.2-2.42.5-1.81.8-2.8-2.82.72.91.1
Patch foraging water rate 6 sec5.78.311.9-3.3-3.3-3.4-3.43.1-3.13.3-2.8-2.82.9-2.82.9-2.72.5-2.42.9-2.4-2.43.32.01.7
Seeking ratio, delayed vs. immediate footshock0.10.10.50.00.30.1-0.00.20.3-0.1-0.3-0.4-0.20.40.5-0.30.5-0.4-0.1-0.1-0.1-0.7-0.5-0.6
Distance traveled before self-admin0.40.41.2-1.0-0.8-0.5-0.10.8-0.90.3-0.9-0.70.2-0.40.3-0.30.7-0.1-0.0-1.1-1.10.20.8-0.2
Distance traveled after self-admin0.91.02.1-1.4-1.0-0.8-0.51.4-1.30.2-1.4-1.10.6-0.40.8-1.01.2-0.80.7-1.4-1.40.50.4-0.5
Extensor digitorum longus weight0.10.41.4-0.7-0.8-0.7-0.90.6-0.00.3-0.2-0.60.3-0.40.9-0.71.0-1.20.8-0.3-0.3-0.7-0.20.9
Bone: elastic displacement2.83.19.32.02.02.12.1-1.81.8-3.11.61.6-1.81.8-1.81.6-1.71.2-1.51.11.1-1.6-1.0-1.6
Bone: elastic work1.31.76.81.61.31.61.5-1.41.2-2.61.31.1-1.31.4-1.31.1-1.30.8-1.10.70.7-1.3-0.4-1.0
Bone: endosteal estimation0.20.40.80.10.40.30.2-0.70.20.50.70.7-0.90.8-0.80.7-0.30.8-0.40.90.9-0.4-0.8-0.7
Bone: endosteal perimeter1.02.05.0-1.9-1.5-1.8-1.81.4-2.21.9-1.4-1.10.8-0.81.2-1.11.3-0.91.2-1.3-1.31.22.00.2
Epididymis fat weight3.37.710.5-3.2-2.6-3.0-2.93.2-2.92.8-2.8-3.12.9-2.73.2-2.72.9-2.72.8-2.6-2.62.81.11.5
Delta time in closed arm before/after self-admin0.40.41.1-1.0-0.3-0.7-0.40.8-0.40.6-0.6-0.50.3-0.50.6-0.61.0-0.5-0.1-0.6-0.6-0.40.10.7
Delta time in open arm before/after self-admin0.80.83.01.31.11.10.8-0.91.7-1.50.50.2-0.40.5-0.10.2-0.10.2-0.00.80.8-0.3-1.6-0.7
Diff in mean of infusions in LGA sessions1.01.12.90.91.11.31.1-0.61.1-1.60.80.7-0.81.0-0.51.2-0.90.3-1.70.60.6-1.5-1.1-0.9
Delay discount exponential model param0.40.42.70.50.60.50.6-0.20.90.10.60.3-0.10.2-0.10.6-0.20.4-0.41.01.0-0.3-1.6-0.3
Extinction: sum of active levers before priming0.20.20.60.10.60.50.7-0.30.4-0.70.20.4-0.80.5-0.40.30.10.6-0.80.00.0-0.7-0.6-0.5
Active lever presses in extinction session 60.20.20.6-0.6-0.4-0.3-0.40.5-0.2-0.1-0.4-0.40.2-0.20.7-0.50.7-0.40.4-0.3-0.30.4-0.4-0.2
Bone: final force0.40.62.1-1.2-1.4-0.9-1.20.8-0.60.5-0.5-0.80.4-0.40.8-0.70.9-1.00.7-0.5-0.5-0.20.10.5
Bone: final moment0.40.62.1-1.2-1.5-0.9-1.20.8-0.60.3-0.6-0.80.4-0.40.8-0.71.0-1.00.7-0.6-0.6-0.30.10.5
Food consumed during 24 hour testing period0.30.31.1-0.4-0.7-0.5-0.70.5-0.51.1-0.4-0.50.6-0.50.7-0.40.4-0.70.5-0.3-0.30.60.20.6
Glucose0.00.10.40.0-0.1-0.0-0.30.10.10.40.50.10.00.20.20.2-0.1-0.20.40.40.40.0-0.6-0.1
Heart weight0.30.42.1-0.60.3-0.10.10.4-0.0-0.9-0.5-0.7-0.2-0.00.3-1.21.4-0.50.6-0.8-0.80.3-0.6-0.2
Delay discount hyperbolic model param0.50.52.80.60.60.60.6-0.30.90.10.80.5-0.30.3-0.10.7-0.30.6-0.51.21.2-0.3-1.7-0.3
Intermittent access intake day 1-15 change0.20.21.4-0.4-0.8-0.3-0.3-0.1-0.31.20.20.1-0.20.1-0.10.3-0.4-0.2-0.20.00.0-0.70.50.5
Intermittent access intake escalation0.20.21.3-0.3-0.7-0.2-0.2-0.4-0.01.10.30.4-0.40.1-0.30.4-0.40.1-0.30.30.3-0.80.20.6
Intermittent access intake escalation 20.10.10.50.3-0.10.20.2-0.50.00.30.70.4-0.40.3-0.40.6-0.60.4-0.50.00.0-0.40.30.3
Intermitt. access day 1 inactive lever presses3.43.77.01.91.91.91.9-2.02.5-1.41.51.9-2.01.8-1.71.7-1.41.4-2.42.22.2-2.7-2.0-1.0
Intermitt. access day 15 inactive lever presses0.40.52.50.81.60.80.9-0.20.6-1.5-0.00.0-0.40.4-0.1-0.00.30.5-0.4-0.2-0.20.1-0.8-0.9
Intermitt. access escalation Index0.80.71.31.01.11.01.1-0.90.6-1.10.91.0-0.70.7-0.80.8-0.71.2-0.70.70.7-0.2-0.6-0.4
Intermittent access day 1 total infusions3.13.65.9-2.3-2.2-2.3-1.72.0-2.01.9-2.1-1.71.9-2.41.5-1.82.0-1.01.2-1.7-1.70.92.22.3
Intermittent access day 15 total infusions2.73.16.1-2.3-2.5-2.2-1.71.7-2.02.5-1.6-1.41.6-2.11.3-1.31.3-1.11.1-1.4-1.40.72.12.3
Intermittent access terminal intake (last 3 days)3.64.06.6-2.3-2.4-2.4-1.82.0-2.32.4-1.9-1.71.9-2.31.7-1.71.7-1.21.5-1.9-1.91.22.62.3
Intermittent access total infusions3.53.96.8-2.4-2.6-2.5-1.91.9-2.22.5-2.0-1.61.8-2.41.5-1.71.8-1.01.2-1.6-1.60.92.52.4
Intermittent access day 1 locomotion1.71.83.6-1.6-1.8-1.7-1.21.4-1.21.4-1.5-1.21.5-1.81.1-1.11.2-1.20.7-0.9-0.90.51.31.9
Intermittent access day 15 total locomotion1.71.83.8-1.7-1.6-1.7-1.21.2-1.41.9-1.5-1.01.1-1.70.9-1.21.3-0.70.4-1.0-1.00.81.81.9
Intermittent access total locomotion2.12.44.9-1.8-2.0-1.9-1.51.5-1.62.1-1.7-1.31.5-1.91.1-1.31.4-1.10.6-1.2-1.20.52.02.2
Intermittent access standard deviation1.01.15.4-1.4-1.8-1.4-1.10.8-1.42.3-0.4-0.30.6-0.9-0.0-0.30.5-0.40.0-0.5-0.50.21.51.5
Left kidney weight3.911.115.8-3.8-3.4-3.5-3.43.6-3.12.7-3.3-3.63.1-3.13.6-3.84.0-3.63.6-3.2-3.23.22.02.2
Right kidney weight2.57.010.4-2.9-2.8-2.8-2.82.8-2.52.3-2.5-2.72.7-2.42.9-2.93.0-3.13.2-2.3-2.32.51.32.0
Cocaine induced anxiety0.80.93.01.51.71.20.9-1.11.1-1.51.10.9-0.40.5-0.40.6-0.81.00.10.90.90.3-0.9-0.5
Post-drug Anxiety0.50.52.91.11.40.90.9-0.60.8-1.70.70.5-0.10.1-0.30.4-0.40.7-0.10.40.4-0.0-0.6-0.0
Baseline Anxiety0.20.20.4-0.6-0.6-0.4-0.10.6-0.50.3-0.3-0.30.3-0.4-0.1-0.00.3-0.2-0.4-0.5-0.5-0.40.70.7
Tail length11.233.945.2-5.5-6.3-6.3-6.45.8-5.55.4-6.0-6.16.7-6.16.2-6.05.0-6.36.5-5.0-5.05.24.95.3
Length with tail16.459.972.0-7.9-8.1-8.4-8.48.1-7.57.1-8.1-8.18.5-8.18.1-8.07.3-7.98.0-7.2-7.27.06.46.7
Length without tail8.318.122.6-4.8-4.3-4.6-4.54.7-4.13.5-4.6-4.44.4-4.44.4-4.54.5-4.34.0-4.3-4.33.83.33.5
Times rat made contact with spout1.01.16.3-1.7-1.7-1.4-1.50.8-1.12.5-0.4-0.6-0.0-0.70.7-0.71.1-0.40.5-0.2-0.20.10.41.4
Lifetime Intake3.13.56.8-2.2-2.3-2.3-1.81.9-2.32.2-1.9-1.61.7-2.21.4-1.71.6-0.81.3-1.7-1.71.32.62.0
Liver weight, left1.01.53.0-1.3-1.4-1.2-1.41.5-1.40.6-1.3-1.31.3-1.11.6-1.11.1-1.11.2-1.2-1.21.70.90.2
Liver weight, right1.42.44.8-1.3-1.0-1.4-1.71.9-1.10.8-1.8-2.01.7-1.32.1-1.81.6-2.21.8-1.5-1.51.70.40.1
Locomotor activity5.99.413.0-3.3-3.1-3.2-3.53.4-3.12.8-3.0-3.33.2-2.83.4-3.23.1-3.63.3-2.8-2.83.11.91.9
Locomotor testing distance2.44.05.7-2.3-2.2-2.1-2.32.2-2.42.0-2.1-2.01.8-1.62.0-1.92.1-2.11.7-2.0-2.02.11.60.7
Locomotor testing rearing0.50.82.5-0.9-1.0-0.8-0.60.8-1.30.9-1.1-0.80.6-0.40.3-0.60.5-0.90.2-1.2-1.20.61.6-0.0
Locomotion in novel chamber0.60.82.3-0.5-0.5-0.6-0.30.8-1.40.4-1.0-0.80.9-0.60.5-0.70.6-0.60.7-1.4-1.41.51.5-0.1
Locomotion in novel chamber post-restriction0.10.10.5-0.5-0.5-0.4-0.30.2-0.40.7-0.2-0.10.1-0.10.2-0.20.1-0.1-0.4-0.2-0.2-0.60.50.5
Fecal boli incidents, locomotor time 10.40.41.9-0.2-0.8-0.5-0.60.60.10.3-0.7-0.90.8-0.51.4-0.70.6-1.20.8-0.3-0.3-0.4-0.10.2
Change in fecal boli incidents, locomotor task0.70.72.10.71.20.81.2-0.80.2-0.80.81.0-0.60.4-1.50.9-0.91.4-1.00.40.40.20.0-0.1
Time >=10cm from walls, locomotor time 10.60.61.31.11.10.90.7-0.90.9-0.70.80.8-0.50.6-0.70.6-0.70.6-0.40.80.8-0.2-0.9-0.4
Bouts of movement, locomotor time 10.60.73.00.80.80.80.5-0.71.0-1.10.80.3-1.01.1-0.10.3-0.20.4-0.11.01.0-0.7-1.7-1.2
Total resting periods, locomotor time 10.70.82.60.91.11.00.7-0.71.0-1.30.70.3-1.11.1-0.20.4-0.20.5-0.40.80.8-0.8-1.6-1.3
Rest time, locomotor task time 11.71.83.81.61.71.61.4-1.41.5-1.91.31.0-1.31.5-0.81.0-1.00.6-0.51.51.5-1.0-2.0-1.4
Distance moved, locomotor task time 10.50.52.6-0.8-1.0-0.8-0.80.7-0.91.6-0.5-0.40.5-0.70.2-0.50.4-0.00.2-0.6-0.60.81.10.5
Vertical activity count, locomotor time 13.23.45.7-2.1-2.1-2.1-1.92.1-2.32.4-1.9-1.61.8-1.81.3-1.51.6-1.21.3-2.0-2.01.91.90.9
Time >=10cm from walls, locomotor time 20.80.91.81.00.80.90.9-1.21.2-1.11.01.0-1.10.6-1.10.7-0.61.3-0.61.01.0-0.4-1.0-0.6
Bouts of movement, locomotor time 20.40.51.2-0.4-0.3-0.4-0.60.6-0.6-0.6-0.8-1.00.6-0.40.8-0.80.5-1.10.7-0.9-0.90.50.7-0.0
Total resting periods, locomotor time 20.20.30.7-0.10.1-0.1-0.40.3-0.4-0.8-0.6-0.70.3-0.10.6-0.70.4-0.70.7-0.7-0.70.50.4-0.3
Rest time, locomotor task time 21.21.32.61.41.61.41.1-1.21.0-1.31.01.0-1.41.4-1.00.8-0.61.0-0.81.01.0-0.8-1.4-1.3
Distance moved, locomotor task time 20.20.31.1-0.7-1.0-0.6-0.70.6-0.11.1-0.2-0.50.5-0.60.5-0.30.3-0.50.3-0.1-0.10.20.10.5
Vertical activity count, locomotor time 24.65.08.3-2.7-2.9-2.6-2.62.5-1.42.5-2.2-2.32.4-2.42.6-2.12.4-2.82.2-1.6-1.61.20.51.8
Light reinforcement 10.30.63.0-0.9-0.7-0.7-0.70.6-0.80.6-0.2-0.40.5-0.60.7-0.70.9-0.11.3-0.6-0.61.7-0.40.3
Light reinforcement 21.01.43.30.90.71.00.8-1.21.3-0.41.61.6-1.01.0-1.11.2-1.00.8-0.71.81.8-1.0-1.8-0.2
Bone: marrow area0.20.40.70.10.40.20.2-0.70.20.50.60.7-0.80.8-0.70.6-0.30.8-0.30.80.8-0.4-0.8-0.7
Bone: maximum diameter1.73.15.0-2.2-2.1-2.0-2.21.9-2.21.9-1.6-1.71.2-1.21.9-1.61.9-1.51.5-1.7-1.71.31.70.6
Bone: maximum force0.20.31.1-0.7-0.8-0.5-0.70.5-0.4-0.1-0.4-0.6-0.0-0.10.6-0.71.0-0.50.5-0.6-0.6-0.30.00.2
Bone: maximum moment0.20.31.2-0.8-0.8-0.5-0.70.4-0.4-0.3-0.4-0.6-0.1-0.10.7-0.71.1-0.50.4-0.6-0.6-0.30.00.1
Mean time between licks in bursts0.81.22.8-0.9-0.6-0.9-0.91.0-1.00.3-1.4-1.30.5-0.81.2-1.71.6-0.71.1-1.6-1.60.91.00.2
Mean num. licks in bursts0.10.10.6-0.5-0.5-0.4-0.20.3-0.40.4-0.2-0.30.1-0.40.1-0.30.2-0.2-0.0-0.5-0.5-0.10.60.8
Cd content in liver0.80.81.9-1.0-0.9-1.0-1.20.7-0.20.7-1.1-0.90.6-0.91.3-1.41.3-0.51.3-0.5-0.50.1-0.60.8
Co content in liver2.93.46.4-1.7-2.5-2.0-2.12.1-2.01.9-1.8-1.82.0-1.82.1-1.61.4-1.51.7-1.8-1.81.42.01.2
Cu content in liver1.01.23.5-0.9-1.9-1.1-1.51.1-0.41.3-0.6-0.91.7-1.11.7-0.50.1-1.71.50.00.00.00.01.0
Fe content in liver0.70.81.3-1.0-1.1-1.1-1.00.8-0.80.6-1.1-0.71.0-1.10.7-0.80.9-0.60.8-0.9-0.90.30.91.1
K content in liver0.60.62.71.10.20.40.1-0.60.80.60.90.40.70.30.21.0-1.6-0.90.11.31.3-0.8-0.20.0
Mg content in liver0.60.61.91.20.70.70.5-0.80.70.31.00.50.20.6-0.20.9-1.4-0.30.01.21.2-0.3-0.3-0.3
Mn content in liver0.20.20.90.3-0.40.0-0.20.0-0.00.90.40.10.50.20.20.6-0.9-0.60.10.60.6-0.30.1-0.1
Na content in liver0.10.10.80.30.1-0.1-0.3-0.00.30.30.3-0.10.5-0.20.10.2-0.6-0.90.40.50.50.2-0.10.2
Rb content in liver0.80.92.21.40.80.80.5-1.21.5-0.61.10.8-0.30.5-0.71.1-1.5-0.2-0.51.41.4-1.5-0.30.3
Se content in liver0.30.31.3-0.3-0.3-0.4-0.20.8-0.50.7-0.7-0.61.2-0.70.7-0.10.4-0.50.3-0.5-0.51.00.4-0.2
Sr content in liver0.10.10.4-0.6-0.4-0.2-0.10.2-0.0-0.6-0.4-0.3-0.2-0.0-0.2-0.40.6-0.20.3-0.3-0.3-0.3-0.4-0.0
Zn content in liver0.50.61.7-0.3-0.3-0.5-0.70.7-0.60.5-0.8-0.91.1-0.71.3-0.80.8-0.61.1-0.7-0.70.90.60.6
Bone: minimum diameter3.76.910.1-3.2-2.9-3.0-3.12.8-3.12.6-2.6-2.52.1-2.22.6-2.73.1-2.12.6-2.5-2.52.42.11.6
Time in familiar zone, hab. session 10.10.10.6-0.00.80.20.10.10.2-0.6-0.3-0.00.1-0.10.2-0.20.1-0.10.40.00.00.4-0.5-0.3
Time in novel zone, hab. session 10.90.91.71.10.60.70.8-1.20.90.11.31.1-0.80.6-1.31.0-1.01.0-1.01.01.0-1.1-0.30.4
Total zone transitions, hab. session 12.94.06.9-2.4-1.9-2.1-2.02.4-2.21.3-2.3-2.31.4-1.61.9-2.32.6-1.51.8-2.4-2.42.31.10.1
Total locomotion distance, hab. session 12.84.07.6-2.5-1.7-2.0-1.82.4-2.31.3-2.4-2.31.3-1.71.8-2.42.8-1.11.6-2.4-2.42.60.90.2
Locomotion velocity, hab. session 13.75.29.4-2.9-1.9-2.3-2.02.7-2.81.5-2.7-2.51.4-1.81.9-2.63.1-1.11.8-2.9-2.93.01.3-0.0
Time in familiar zone, hab. session 20.10.10.3-0.10.4-0.1-0.10.20.1-0.0-0.3-0.40.3-0.20.2-0.40.5-0.50.4-0.2-0.20.1-0.20.3
Time in novel zone, hab. session 20.50.51.10.60.50.70.7-0.80.6-0.80.70.9-1.00.8-0.60.6-0.61.1-0.70.60.6-0.5-0.6-0.7
Total zone transitions, hab. session 20.81.02.7-1.2-0.5-0.6-0.41.2-1.40.3-1.4-1.30.0-0.20.8-1.11.4-0.40.1-1.7-1.71.00.7-1.1
Total locomotion distance, hab. session 20.50.61.5-1.1-0.5-0.5-0.20.9-1.20.5-1.0-0.9-0.30.00.5-0.81.10.1-0.1-1.2-1.20.90.4-1.1
Locomotion velocity, hab. session 20.60.92.0-1.2-0.5-0.6-0.31.1-1.40.5-1.2-1.0-0.20.10.5-0.91.10.1-0.1-1.4-1.41.20.7-1.4
Novel to familiar place preference ratio0.20.20.70.2-0.3-0.2-0.10.3-0.0-0.2-0.6-0.60.6-0.60.6-0.70.6-0.10.8-0.5-0.50.80.20.2
Novelty place preference0.10.10.40.4-0.00.10.10.10.2-0.5-0.4-0.40.3-0.40.4-0.60.50.10.7-0.3-0.30.6-0.10.0
Time in novel zone, NPP test0.20.20.60.3-0.2-0.0-0.00.20.2-0.4-0.5-0.50.5-0.50.5-0.70.6-0.20.8-0.4-0.40.6-0.00.2
Total zone transitions, NPP test1.52.14.2-1.5-1.2-1.2-1.21.7-1.70.6-1.8-1.81.0-0.91.4-1.61.7-1.51.0-2.0-2.01.31.2-0.2
Total locomotion distance, NPP test1.01.32.7-1.5-1.2-1.0-0.91.4-1.61.0-1.4-1.30.6-0.60.9-1.11.3-0.80.5-1.6-1.61.40.8-0.4
Locomotion velocity, NPP test0.60.82.0-1.1-0.9-0.7-0.51.1-1.40.8-1.0-0.90.3-0.30.5-0.70.9-0.40.1-1.3-1.31.20.8-0.7
Intraocular pressure1.62.24.91.11.41.41.5-1.51.1-0.51.61.5-2.21.6-1.41.5-1.22.2-2.21.21.2-1.6-1.0-0.9
Delta distance traveled before/after self-admin0.10.10.4-0.4-0.3-0.2-0.20.4-0.20.2-0.2-0.10.30.10.1-0.20.0-0.70.5-0.1-0.10.1-0.6-0.3
Delta ambulatory time before/after self-admin0.30.31.10.50.40.50.5-0.40.6-0.60.50.5-0.20.7-0.40.4-0.6-0.20.10.70.7-0.4-1.0-0.7
Parametrial fat weight0.20.32.70.60.30.60.1-0.10.3-1.10.2-0.30.00.60.50.2-0.3-0.40.50.10.10.4-0.4-1.6
Pavlov. Cond. lever latency0.60.81.3-0.9-1.1-0.9-1.00.9-0.80.6-1.1-1.01.0-1.00.9-1.00.5-0.80.9-0.9-0.90.90.50.8
Pavlov. Cond. magazine entry latency0.30.42.20.51.00.60.7-0.40.3-0.30.20.3-1.10.8-0.30.10.31.0-0.40.10.10.0-0.3-1.5
Pavlov. Cond. change in total contacts0.70.81.40.60.50.70.8-0.90.60.40.91.0-1.11.0-1.01.0-0.71.2-1.21.01.0-0.9-0.5-0.8
Pavlov. Cond. index score0.40.52.10.61.10.80.8-0.60.5-0.50.60.5-1.11.0-0.50.50.10.9-0.60.50.5-0.4-0.5-1.4
Pavlov. Cond. latency score0.50.61.90.61.10.80.8-0.70.6-0.50.70.6-1.11.1-0.60.50.00.9-0.70.50.5-0.5-0.6-1.4
Pavlov. Cond. lever contacts0.00.10.20.10.40.20.2-0.20.1-0.10.20.2-0.30.3-0.20.20.20.3-0.10.20.2-0.1-0.1-0.4
Pavlov. Cond. magazine entry number0.20.21.7-0.4-0.6-0.5-0.50.1-0.00.1-0.1-0.10.7-0.70.1-0.2-0.2-0.60.5-0.0-0.0-0.1-0.11.3
Pavlov. Cond. intertrial magazine entries0.00.00.20.1-0.2-0.1-0.10.0-0.20.10.30.10.3-0.10.10.3-0.30.0-0.30.00.00.00.50.4
Pavlov. Cond. lever-magazine prob. diff.0.30.31.90.50.90.60.6-0.40.4-0.40.30.3-0.90.9-0.30.20.20.7-0.40.30.3-0.3-0.5-1.4
Pavlov. Cond. response bias0.10.20.80.40.50.40.4-0.30.10.20.30.3-0.60.6-0.30.30.00.7-0.40.30.30.00.0-0.9
Pavlov. Cond. lever latency0.20.20.80.10.10.10.1-0.4-0.00.10.40.6-0.40.4-0.50.7-0.70.2-0.70.40.4-0.90.60.4
Pavlov. Cond. magazine entry latency0.40.41.2-0.6-0.4-0.7-0.40.5-0.90.8-0.5-0.30.5-0.80.4-0.50.40.60.5-0.6-0.61.11.00.8
Pavlov. Cond. change in total contacts2.73.86.4-1.8-1.7-1.9-1.92.0-2.11.7-2.2-2.21.8-1.82.0-2.21.9-1.42.1-2.2-2.22.51.80.7
Pavlov. Cond. index score0.91.22.8-1.0-1.0-1.1-1.01.1-1.21.2-1.1-1.11.1-1.21.1-1.10.9-0.31.2-1.1-1.11.71.00.5
Pavlov. Cond. latency score0.60.72.1-0.7-0.7-0.8-0.70.9-1.01.0-0.8-0.80.9-0.90.8-0.80.6-0.21.0-0.9-0.91.50.80.2
Pavlov. Cond. lever contacts0.40.51.4-0.6-0.6-0.6-0.60.7-0.10.4-0.6-0.90.6-0.61.0-1.01.1-0.71.2-0.5-0.51.0-0.8-0.2
Pavlov. Cond. magazine entry number0.70.92.71.01.01.00.8-0.91.4-1.50.80.7-0.70.9-0.70.7-0.6-0.2-0.81.01.0-1.6-1.1-0.3
Pavlov. Cond. intertrial magazine entries0.10.20.70.20.30.1-0.00.20.3-0.8-0.2-0.40.4-0.20.5-0.40.5-0.80.6-0.1-0.10.2-0.50.0
Pavlov. Cond. lever-magazine prob. diff.1.01.32.7-1.1-1.1-1.2-1.11.2-1.31.4-1.1-1.11.1-1.31.1-1.20.9-0.41.2-1.2-1.21.71.10.7
Pavlov. Cond. response bias0.71.01.8-1.0-1.0-1.0-1.01.0-0.70.9-1.0-1.20.9-1.01.1-1.31.2-0.61.3-0.9-0.91.4-0.10.3
Time in closed arm before self-admin0.40.41.0-0.4-0.3-0.6-0.50.3-0.90.6-0.6-0.60.4-0.60.3-0.90.8-0.11.0-0.8-0.80.70.70.6
Time in closed arm after self-admin0.50.51.3-1.1-0.8-0.9-0.60.6-0.50.5-0.6-0.60.6-0.90.5-0.90.9-0.71.1-0.5-0.50.2-0.11.1
Time in open arm before self-admin0.20.30.80.10.10.30.4-0.2-0.0-0.10.40.6-0.50.6-0.70.9-0.90.3-0.90.20.2-0.30.5-0.9
Time in open arm after self-admin0.40.51.51.11.00.90.6-0.51.2-1.20.20.1-0.50.60.10.3-0.00.2-0.60.40.4-0.3-0.5-1.0
Bone: periosteal estimation0.40.81.7-1.3-1.1-1.1-1.20.9-1.31.0-0.8-0.80.5-0.50.8-0.81.1-0.60.9-0.8-0.80.70.80.3
Bone: periosteal perimeter1.11.93.3-1.7-1.6-1.6-1.71.5-1.81.1-1.5-1.30.9-0.91.5-1.31.5-1.21.3-1.4-1.41.01.60.4
Bone: post-yield work0.10.20.9-0.6-0.1-0.4-0.40.10.20.3-0.0-0.1-0.2-0.40.4-0.20.90.2-0.40.10.1-0.4-0.41.0
Progressive ratio test 1 active lever presses6.66.914.8-3.3-3.8-3.4-2.82.6-2.73.6-2.4-2.12.7-3.12.0-2.01.9-2.11.8-1.7-1.71.22.63.5
Progressive ratio test 1 breakpoint6.46.713.6-3.3-3.7-3.3-2.82.6-2.73.4-2.4-2.12.6-3.02.0-2.02.0-2.01.8-1.8-1.81.32.53.3
Progressive ratio test 1 inactive lever presses0.10.20.5-0.6-0.6-0.5-0.30.3-0.30.7-0.6-0.20.1-0.30.4-0.40.6-0.1-0.1-0.2-0.2-0.50.30.3
Progressive ratio test 2 active lever presses2.72.95.3-2.1-2.3-2.2-1.61.7-1.92.3-1.6-1.41.7-2.11.2-1.41.4-0.90.8-1.4-1.40.92.12.3
Progressive ratio test 2 breakpoint3.13.56.8-2.2-2.5-2.4-1.91.9-2.12.6-1.7-1.51.7-2.21.4-1.51.5-1.00.8-1.5-1.50.82.22.4
Progressive ratio test 2 inactive lever presses0.30.41.4-0.9-0.8-0.8-0.30.6-0.50.7-0.6-0.40.5-1.00.3-0.40.8-0.1-0.1-0.6-0.60.10.41.2
Incentive Sensitization - Responses1.51.53.5-1.3-1.5-1.4-1.21.3-1.31.9-1.1-1.11.0-1.31.1-0.91.0-0.70.2-1.1-1.10.41.71.5
Incentive Sensitization - Breakpoint1.21.23.0-1.1-1.3-1.3-1.21.1-1.11.7-1.0-1.01.0-1.31.0-0.80.9-0.70.2-1.0-1.00.31.51.4
Sum of active levers in priming session hrs 5-60.10.11.0-0.2-0.2-0.1-0.2-0.10.10.1-0.10.2-0.40.20.1-0.30.50.40.40.20.20.2-1.0-0.3
Progressive ratio1.51.84.21.51.61.41.8-1.40.2-1.41.01.3-1.41.3-1.81.2-1.62.1-1.60.50.5-0.41.0-1.0
Food seeking constrained by brief footshock0.91.15.4-1.0-1.5-1.3-1.11.0-0.91.7-0.6-0.51.5-1.50.7-0.70.4-0.50.7-0.4-0.40.30.82.3
Seeking ratio, punishment vs. effort1.41.73.4-1.4-1.8-1.5-1.71.4-0.51.6-0.9-1.21.6-1.41.6-1.01.2-1.81.4-0.5-0.50.2-0.51.6
Retroperitoneal fat weight3.511.415.9-3.5-3.0-3.4-3.23.8-4.02.8-3.7-3.93.3-2.83.3-3.73.4-3.13.6-3.8-3.84.02.80.8
Reaction time number correct0.10.10.9-0.40.2-0.1-0.10.1-0.1-0.10.40.2-0.1-0.1-0.00.00.10.30.00.20.21.0-0.50.1
Reaction time mean minus median0.70.91.91.21.31.21.4-0.90.9-1.30.80.7-1.21.1-0.90.5-0.41.1-1.00.40.4-0.6-0.7-1.0
Reaction time mean minus median AUC0.91.13.11.31.81.31.6-1.11.0-1.10.90.8-1.31.2-1.20.7-0.51.2-1.20.50.5-0.8-0.8-0.8
Reaction time num false alarms1.21.73.31.50.91.31.1-1.41.6-1.11.31.3-0.81.1-1.21.5-1.50.5-0.91.71.7-1.8-1.1-0.6
Reaction time num false alarms AUC1.62.23.81.61.11.61.3-1.61.9-1.61.41.5-1.11.4-1.31.6-1.60.7-1.21.81.8-1.9-1.5-1.0
Reaction time trials correct on left0.10.10.9-0.40.2-0.1-0.10.1-0.1-0.10.40.2-0.1-0.1-0.00.00.10.30.00.20.21.0-0.50.1
Reaction time trials on left0.10.10.8-0.30.3-0.0-0.10.0-0.0-0.20.40.3-0.20.0-0.10.10.00.4-0.10.30.30.9-0.6-0.0
Reaction time mean0.10.10.40.00.20.10.30.1-0.30.3-0.0-0.0-0.50.4-0.40.10.10.2-0.7-0.3-0.3-0.60.5-0.5
Reaction time mean AUC0.10.10.5-0.20.1-0.10.10.2-0.30.4-0.2-0.2-0.30.2-0.3-0.10.3-0.1-0.5-0.5-0.5-0.70.5-0.1
Median of all reaction times0.20.30.8-0.6-0.4-0.5-0.40.6-0.70.9-0.5-0.50.1-0.20.1-0.30.5-0.4-0.3-0.7-0.7-0.40.80.1
Reaction time omissions2.73.75.11.91.82.12.3-1.91.8-2.21.82.0-2.02.0-2.21.9-1.82.0-1.81.81.8-1.7-1.6-1.9
Reaction time false alarm rate1.42.05.21.70.91.51.3-1.51.8-1.31.21.3-1.01.3-1.21.5-1.50.6-1.21.61.6-2.3-1.0-0.9
Reaction time premature initiation rate0.20.32.7-0.6-0.5-0.0-0.10.3-0.20.2-0.1-0.1-0.80.6-0.1-0.20.70.30.0-0.1-0.10.3-0.9-1.7
Reaction time premature initiations0.20.31.3-0.9-0.5-0.3-0.30.4-0.30.3-0.1-0.0-0.60.3-0.1-0.30.80.30.1-0.1-0.10.8-1.0-1.1
Std. dev. reaction times0.91.22.51.21.31.31.6-1.10.9-1.30.90.9-1.41.4-1.30.8-0.71.2-1.20.60.6-1.1-0.5-1.3
Reaction time trials completed0.10.10.8-0.30.3-0.0-0.10.0-0.0-0.20.40.3-0.20.0-0.10.10.00.4-0.10.30.30.9-0.6-0.0
Reaction time trials AUC0.10.10.9-0.40.2-0.1-0.20.1-0.1-0.00.40.2-0.1-0.0-0.00.10.00.30.10.30.31.0-0.50.0
Run reversals in cocaine runway, females1.41.32.4-1.3-1.3-1.1-0.91.5-1.40.5-1.2-1.50.8-0.71.0-0.81.1-1.60.2-1.6-1.60.61.50.1
Run reversals in cocaine runway, males0.10.10.30.00.50.10.20.00.30.1-0.10.00.2-0.30.10.10.20.3-0.20.10.10.1-0.60.3
Latency to leave start box in cocaine runway0.40.51.6-0.6-0.2-0.6-0.80.7-0.70.2-0.6-0.70.7-0.60.7-1.00.80.11.2-0.5-0.51.3-0.00.3
Latency to leave start box in cocaine runway, F0.30.41.60.60.80.60.5-0.40.2-0.30.60.7-0.30.5-0.50.5-0.51.30.10.50.50.3-0.8-0.8
Latency to leave start box in cocaine runway, M3.73.55.8-1.9-1.5-2.0-2.21.8-1.61.1-2.0-2.11.9-2.12.0-2.42.1-1.82.0-1.7-1.71.71.12.2
Std. dev. time between licks in bursts0.40.51.80.40.70.40.30.1-0.2-1.1-0.8-0.5-0.20.30.5-0.80.90.20.0-1.1-1.10.50.2-1.3
Total sessions with >9 infusions2.52.85.2-1.9-2.3-2.0-1.61.7-2.01.8-1.4-1.41.9-2.11.4-1.21.1-1.11.4-1.3-1.31.22.12.0
Short access day 1 total inactive lever presses0.20.22.0-0.1-0.10.10.4-0.10.30.0-0.00.1-0.60.10.10.30.30.2-1.3-0.2-0.2-1.4-0.00.3
Short access day 10 total inactive lever presses1.31.58.11.72.61.71.5-0.81.4-2.80.60.3-0.70.9-0.10.3-0.00.4-0.6-0.1-0.1-0.6-1.3-1.2
Short access day 1 total infusions2.52.75.6-1.8-1.9-1.8-1.51.8-2.11.4-1.5-1.61.6-1.71.6-1.41.4-1.31.2-1.8-1.80.92.41.3
Short access day 10 total infusions4.75.27.5-2.6-2.7-2.7-2.42.5-2.32.7-2.3-2.32.3-2.62.2-2.32.2-1.92.1-1.8-1.81.52.22.1
Short access total infusions4.55.07.0-2.5-2.6-2.6-2.22.4-2.62.2-2.2-2.32.2-2.42.1-2.12.1-1.61.9-2.2-2.21.62.61.8
Short access day 1 locomotion3.13.35.2-2.2-2.3-2.1-1.82.2-1.71.8-1.7-2.01.9-1.91.8-1.61.8-2.11.4-1.8-1.80.61.51.5
Short access day 10 total locomotion0.30.31.7-0.1-0.5-0.00.4-0.10.10.5-0.20.4-0.20.2-0.70.5-0.3-0.1-1.30.70.7-1.30.40.1
Short access total locomotion1.31.34.4-1.5-2.1-1.5-1.11.2-1.01.9-1.1-1.01.0-1.20.8-0.70.9-1.40.2-0.4-0.4-0.31.11.4
One hour access (0.3 mA shock)2.02.38.0-1.5-1.7-1.8-1.31.2-2.42.1-1.4-0.71.2-1.60.6-1.10.90.40.7-1.4-1.41.82.81.6
Compulsive drug intake1.21.23.31.51.81.41.0-1.00.5-1.70.90.9-0.81.3-0.70.7-1.01.2-0.00.40.41.0-0.5-1.8
One hour access (shock baseline)2.83.26.4-2.3-2.5-2.3-1.51.7-2.22.5-1.9-1.31.4-2.11.0-1.51.6-0.50.5-1.6-1.60.82.52.2
Social response proportion3.84.17.1-2.4-1.6-2.0-2.12.5-1.50.7-2.1-2.42.3-2.12.5-2.22.2-2.72.3-2.1-2.11.60.21.4
Social responses2.63.45.4-2.1-1.3-1.7-1.82.2-2.00.4-2.0-2.11.8-1.52.0-1.92.0-1.82.0-2.3-2.32.30.70.3
Social time0.50.72.7-1.7-1.2-1.0-0.90.9-0.10.8-0.4-0.60.4-0.90.6-0.30.7-0.9-0.1-0.3-0.3-0.6-0.91.6
Soleus weight0.10.20.7-0.6-0.5-0.4-0.50.4-0.40.1-0.1-0.40.10.20.2-0.30.3-0.70.8-0.3-0.3-0.20.1-0.4
Bone: stiffness1.62.65.5-2.0-2.4-1.8-2.11.8-1.11.6-1.6-1.91.4-1.31.9-1.71.9-2.01.7-1.1-1.10.50.10.9
Tibialis anterior weight0.20.52.00.60.30.70.4-0.60.8-0.81.00.7-1.11.1-0.50.5-0.40.2-0.40.60.6-1.4-0.4-0.7
Time to tail flick, vehicle, before self-admin1.71.75.2-1.5-1.6-1.7-1.60.9-1.72.3-1.2-0.80.5-1.20.9-1.31.3-0.11.2-1.2-1.20.91.61.1
Time to tail flick, vehicle, after self-admin1.71.84.21.31.21.41.5-1.32.1-1.51.21.1-1.21.1-1.11.2-1.10.0-1.31.41.4-1.9-1.8-0.6
Time to tail flick, test, before self-admin0.20.20.9-0.1-0.3-0.3-0.40.2-0.50.30.30.21.0-0.4-0.10.3-0.7-0.50.80.30.30.60.40.5
Time to tail flick, test, after self-admin0.20.20.60.10.3-0.00.0-0.3-0.2-0.10.50.60.2-0.2-0.70.3-0.70.70.80.50.50.50.30.6
Delta time to tail flick, vehicle, before/after SA3.33.36.82.12.12.11.9-1.72.5-2.61.81.3-1.21.6-1.31.7-1.80.2-1.32.02.0-1.8-2.3-1.0
Delta time to tail flick, test, before/after SA0.20.21.10.40.80.30.3-0.60.4-0.40.30.3-0.50.0-0.4-0.10.21.00.00.20.20.2-0.40.3
Tibia length11.432.140.9-6.4-5.9-6.2-6.06.2-6.35.4-6.2-5.75.5-5.55.7-5.75.6-5.15.3-5.8-5.85.25.04.0
Ambulatory time before self-admin0.50.51.5-1.2-1.2-0.7-0.30.9-0.70.4-1.0-0.80.4-0.60.4-0.40.8-0.6-0.0-1.1-1.1-0.00.60.2
Ambulatory time after self-admin1.51.73.5-1.7-1.2-1.1-0.71.7-1.60.3-1.8-1.51.0-0.61.1-1.21.4-1.21.1-1.9-1.91.00.8-0.7
Bone: tissue strength0.20.20.8-0.5-0.9-0.5-0.60.2-0.00.6-0.2-0.30.5-0.40.2-0.20.0-0.60.50.10.1-0.2-0.60.9
Total heroin consumption0.30.43.40.50.70.60.3-0.3-0.2-0.80.10.2-0.50.9-0.30.1-0.20.50.5-0.1-0.10.9-0.1-1.8
Bone: trabecular number0.81.21.90.81.11.00.7-1.31.1-0.71.31.3-1.41.1-1.11.1-1.01.3-0.81.31.3-1.1-1.0-0.6
Bone: trabecular spacing0.20.20.80.20.50.20.30.2-0.5-0.6-0.2-0.2-0.0-0.1-0.0-0.30.50.4-0.2-0.8-0.80.60.9-0.1
Bone: trabecular thickness0.60.71.6-0.9-1.1-0.8-1.00.7-0.00.3-0.8-0.80.9-1.01.0-0.90.9-1.21.3-0.2-0.20.5-0.80.9
Bone: trabecular tissue density0.10.10.60.1-0.8-0.1-0.10.3-0.30.5-0.1-0.30.6-0.2-0.00.2-0.5-0.40.1-0.2-0.20.70.3-0.5
Water consumed over 24 hours0.40.42.1-0.7-1.1-0.8-0.90.40.01.4-0.3-0.40.4-0.50.5-0.30.5-0.70.40.30.3-0.5-0.51.0
Number of responses in last shaping day0.80.84.0-1.1-0.9-1.1-0.60.8-1.11.2-0.7-0.41.0-1.30.2-0.50.5-0.40.1-0.5-0.50.41.42.0