Hub : Genes

Vcp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Vcp 0.03 0.02 6.8e-03 0.02 0.01 0.02 0.02 6.7e-03 9.0e-02 8.1e-03 1.0e-02
2 BLA mRNA stability Vcp 0.05 0.04 6.7e-03 0.03 0.03 0.04 0.03 9.6e-03 1.2e-02 4.6e-03 1.3e-02
3 BLA gene expression Vcp 0.05 0.04 8.8e-03 0.01 0.03 0.01 0.02 5.0e-02 1.4e-02 5.4e-02 3.4e-02
4 PL mRNA stability Vcp 0.02 0.02 8.0e-03 0.02 0.02 0 0.02 2.9e-03 2.8e-03 1.1e-01 5.5e-03
5 Adipose mRNA stability Vcp 0.05 0.03 1.0e-05 0.04 0.04 0.03 0.04 3.6e-05 5.8e-05 8.3e-04 5.9e-05
6 pVTA gene expression Vcp 0.09 0.06 1.4e-07 0.09 0.09 0.1 0.09 1.7e-07 7.0e-08 2.2e-08 1.3e-07
7 IC gene expression Vcp 0.11 0.08 1.3e-03 0.04 0.05 0.03 0.04 8.9e-03 4.6e-03 2.4e-02 6.9e-03
8 NAcc gene expression Vcp 0.04 0.03 4.3e-07 0.04 0.03 0.04 0.01 5.3e-07 1.7e-05 9.9e-07 8.0e-03
9 Liver mRNA stability Vcp 0.04 0.03 4.3e-04 0.01 0.02 0.02 0.01 4.5e-02 5.5e-03 2.6e-03 8.9e-03
10 Adipose gene expression Vcp 0.03 0.02 3.8e-03 -0 0 0 -0 6.1e-01 1.8e-01 2.0e-01 4.8e-01
11 PL gene expression Vcp 0.06 0.04 3.3e-05 0.03 0.04 0.04 0.04 1.3e-04 2.1e-05 7.7e-05 7.5e-05
12 Liver gene expression Vcp 0.04 0.04 2.6e-03 0.02 0.01 0.01 0.01 4.6e-03 2.2e-02 1.5e-02 1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.32.43.41.3-1.3-1.61.7-1.91.7-1.81.5-0.2-1.7-1.81.2
Area under the delay curve0.60.81.6-0.60.60.9-1.01.0-1.11.1-1.30.11.11.1-0.6
BMI with tail1.34.46.22.3-2.3-2.52.5-2.42.4-2.42.00.6-1.9-2.00.7
BMI without tail1.05.58.02.7-2.7-2.82.8-2.72.7-2.62.31.1-1.9-2.00.3
Body weight2.39.917.24.1-4.1-3.83.7-3.43.3-3.03.22.8-1.6-1.7-1.0
Weight adjusted by age0.10.21.00.5-0.5-0.20.2-0.0-0.00.2-0.10.80.40.5-1.0
Bone surface0.61.21.91.2-1.2-1.31.3-1.41.2-1.21.10.5-0.8-0.90.1
Bone volume0.61.21.81.0-1.0-1.21.2-1.31.2-1.31.10.0-1.1-1.20.6
Breakpoint value in progressive ratio session2.34.29.30.1-0.01.3-1.52.0-2.02.3-1.91.93.03.0-2.8
Number of licking bursts1.85.68.02.5-2.6-2.72.7-2.62.7-2.62.81.1-2.1-2.10.3
Context. condit. distance diff. score0.10.10.2-0.40.40.3-0.30.3-0.20.2-0.2-0.5-0.0-0.00.4
Locomotion velocity, session 12.73.011.71.1-1.1-0.1-0.10.5-0.51.2-0.63.02.42.3-3.4
Locomotion distance, session 10.70.93.70.9-0.9-0.30.20.1-0.00.4-0.21.71.11.1-1.9
Locomotion velocity, session 22.12.53.81.5-1.5-1.81.8-2.01.8-1.91.60.2-1.7-1.70.6
Locomotion distance, session 21.52.14.12.0-2.0-1.71.6-1.31.4-1.11.21.9-0.2-0.3-1.4
Locomotion velocity, session 30.60.62.20.5-0.50.0-0.10.3-0.30.6-0.31.41.21.1-1.5
Locomotion distance, session 31.41.63.41.8-1.8-1.51.4-1.21.2-0.91.01.7-0.1-0.1-1.1
Stereotopy head waving bouts, day 30.70.92.1-0.10.10.5-0.60.8-0.71.0-0.21.11.51.4-1.3
Stereotopy head waving duration, day 30.40.51.0-0.50.50.7-0.80.9-0.70.9-0.10.41.01.0-0.6
Locomotion velocity, session 70.10.10.1-0.30.30.3-0.30.3-0.30.3-0.3-0.20.20.20.0
Locomotion distance, session 70.20.20.60.6-0.6-0.50.4-0.30.3-0.20.00.80.20.1-0.6
Stereotopy head waving bouts, day 70.81.02.21.3-1.2-1.01.0-0.90.9-0.71.51.3-0.1-0.2-0.6
Stereotopy head waving duration, day 70.40.51.70.9-0.9-0.70.7-0.70.7-0.51.30.9-0.1-0.2-0.3
Locomotion velocity, session 80.40.52.00.3-0.30.0-0.10.2-0.20.5-0.31.20.90.9-1.4
Locomotion distance, session 80.30.41.50.7-0.7-0.40.3-0.10.20.10.01.10.60.6-1.2
Degree of sensitization distance0.70.81.4-1.21.11.1-1.00.9-0.90.8-0.9-0.80.40.40.4
Degree of sensitization stereotypy1.01.22.41.3-1.2-1.21.2-1.21.2-1.11.50.8-0.7-0.70.0
Conditioned locomotion0.40.41.20.2-0.20.3-0.30.6-0.50.7-0.30.91.00.9-1.1
Cocaine response after cond. corrected2.13.15.3-1.11.11.6-1.71.8-1.82.1-1.80.82.32.3-1.8
Cocaine response after cond. not corrected2.02.95.5-0.90.91.5-1.61.7-1.72.0-1.61.12.32.3-2.0
Cocaine response before conditioning0.70.91.51.0-1.0-1.11.1-1.11.1-1.01.20.3-0.8-0.90.2
Saline control response0.81.13.41.3-1.3-0.90.8-0.60.7-0.31.01.90.50.4-1.5
Bone: connectivity density0.81.32.20.7-0.7-1.11.1-1.31.2-1.41.0-0.6-1.4-1.51.2
Bone: cortical apparent density0.50.82.5-0.20.2-0.20.4-0.40.6-0.80.6-1.2-1.3-1.31.6
Bone: cortical area3.04.86.92.0-2.0-2.32.4-2.52.5-2.62.4-0.1-2.5-2.51.2
Bone: cortical porosity0.20.20.4-0.60.60.5-0.50.3-0.50.3-0.3-0.50.10.10.4
Bone: cortical porosity0.00.00.0-0.10.10.1-0.1-0.0-0.10.10.10.10.10.1-0.1
Bone: cortical thickness1.83.05.61.0-1.0-1.51.6-1.61.8-2.01.8-1.1-2.4-2.42.0
Bone: cortical thickness0.30.41.7-0.50.50.3-0.20.2-0.1-0.20.0-1.3-0.7-0.71.3
Bone: cortical tissue density0.40.62.1-0.20.2-0.10.2-0.30.4-0.60.5-1.2-1.1-1.11.5
Condit. Reinf. active minus inactive responses0.50.60.70.8-0.8-0.80.9-0.90.8-0.90.90.2-0.8-0.80.0
Condit. Reinf. active-inactive response ratio0.40.40.8-0.90.90.8-0.80.8-0.70.6-0.7-0.70.20.20.4
Condit. Reinf. active responses2.53.24.51.9-1.9-2.12.1-2.12.0-2.02.00.6-1.7-1.70.1
Condit. Reinf. inactive responses3.14.16.02.0-2.0-2.32.4-2.42.3-2.42.10.4-2.1-2.10.5
Incentive salience index mean3.34.36.22.5-2.5-2.52.5-2.42.2-2.12.21.5-1.4-1.5-0.6
Condit. Reinf. lever presses7.110.617.24.1-4.1-3.93.8-3.63.5-3.13.43.1-1.6-1.8-1.6
Condit. Reinf. active minus inactive responses0.60.81.30.9-0.9-1.01.1-1.01.1-1.10.90.1-1.0-1.00.4
Condit. Reinf. active-inactive response ratio0.10.20.50.2-0.2-0.40.4-0.50.5-0.60.2-0.3-0.7-0.60.5
Condit. Reinf. active responses1.92.73.81.9-1.9-1.91.9-1.71.9-1.81.70.7-1.4-1.40.3
Condit. Reinf. inactive responses2.53.75.62.0-2.0-2.12.2-1.92.2-2.22.40.4-1.8-2.00.9
Condit. Reinf. lever presses3.14.56.31.7-1.8-2.22.3-2.22.4-2.52.4-0.3-2.4-2.51.6
Condit. Reinf. lever reinforcers received2.23.14.52.0-2.0-2.12.1-1.92.1-2.01.90.8-1.5-1.60.3
Conditioned reinforcement - actives0.10.21.2-0.20.10.1-0.20.3-0.00.11.10.70.40.3-0.5
Conditioned reinforcement - inactives0.20.51.0-0.70.60.7-0.71.0-0.50.80.40.40.90.8-0.4
Conditioned locomotion0.20.20.70.1-0.20.1-0.10.3-0.30.40.30.90.80.7-0.7
Patch foraging indifference point 0 sec0.71.96.80.7-0.7-0.0-0.20.5-0.51.0-0.62.41.91.9-2.6
Patch foraging indifference point AUC3.37.812.03.5-3.5-3.43.3-3.33.1-2.82.62.2-1.7-1.8-0.9
Delay disc. indifference point, 0s delay1.21.32.0-0.90.91.2-1.31.4-1.41.4-1.10.11.41.4-0.7
Delay disc. indifference point, 16s delay1.42.03.5-0.50.51.3-1.41.7-1.61.7-1.60.71.91.9-1.3
Delay disc. indifference point, 2s delay0.20.20.40.0-0.0-0.30.3-0.40.4-0.50.5-0.4-0.6-0.60.6
Delay disc. indifference point, 24s delay0.10.10.7-0.10.20.3-0.30.3-0.40.3-0.8-0.30.10.20.1
Delay disc. indifference point, 4s delay0.10.10.3-0.30.30.3-0.30.3-0.50.4-0.6-0.10.40.4-0.1
Delay disc. indifference point, 8s delay0.00.00.10.0-0.0-0.10.1-0.2-0.0-0.1-0.4-0.0-0.0-0.00.0
Indifference point function ln k1.03.04.6-2.02.02.1-2.12.1-2.01.9-1.6-1.11.31.30.3
Indifference point function log k1.03.04.6-2.02.02.1-2.12.1-2.01.9-1.6-1.11.31.30.3
Patch foraging total patch changes 0 sec0.51.66.01.1-1.1-0.50.30.0-0.10.5-0.12.41.51.5-2.4
Patch foraging total patch changes 12 sec1.41.92.71.7-1.7-1.61.6-1.61.5-1.41.31.0-0.9-0.9-0.3
Patch foraging total patch changes 18 sec0.30.71.31.1-1.1-0.90.9-0.80.8-0.60.41.2-0.1-0.1-1.0
Patch foraging total patch changes 24 sec0.61.93.21.8-1.8-1.71.6-1.61.4-1.21.21.7-0.4-0.4-1.1
Patch foraging total patch changes 6 sec1.52.66.72.2-2.2-1.71.5-1.41.3-0.80.92.60.30.3-2.1
Patch foraging time to switch 0 sec0.72.54.3-2.12.11.9-1.81.7-1.61.3-1.4-1.80.40.41.2
Patch foraging water rate 0 sec0.41.63.51.7-1.7-1.41.3-1.01.1-0.70.91.90.10.0-1.5
Patch foraging water rate 12 sec0.00.10.40.2-0.20.0-0.10.1-0.10.3-0.00.50.50.5-0.6
Patch foraging water rate 18 sec0.30.81.50.5-0.5-0.70.8-0.81.0-1.01.2-0.4-1.0-1.11.0
Patch foraging water rate 24 sec0.40.61.9-0.40.4-0.00.1-0.30.4-0.60.4-1.3-1.1-1.01.4
Patch foraging water rate 6 sec0.60.92.31.0-1.1-1.11.1-0.91.0-1.01.50.7-0.6-0.70.1
Seeking ratio, delayed vs. immediate footshock2.33.35.32.3-2.3-2.12.1-1.91.9-1.92.01.0-1.5-1.50.1
Distance traveled before self-admin1.94.19.63.1-3.1-2.22.1-1.61.7-1.52.32.2-0.5-0.7-1.2
Distance traveled after self-admin1.42.56.61.5-1.5-1.61.7-1.41.7-1.72.60.3-1.6-1.70.7
Extensor digitorum longus weight3.815.323.64.9-4.8-4.64.6-4.24.3-4.04.42.8-2.6-2.7-0.7
Bone: elastic displacement3.84.88.3-2.92.92.6-2.52.2-2.31.9-2.5-2.50.70.91.3
Bone: elastic work2.12.89.7-2.02.11.3-1.10.9-0.80.2-0.9-3.1-1.1-1.02.7
Bone: endosteal estimation0.82.03.51.9-1.9-1.61.5-1.61.3-1.11.41.8-0.2-0.3-1.3
Bone: endosteal perimeter0.81.93.91.9-1.9-1.51.4-1.41.1-0.91.12.0-0.0-0.0-1.6
Epididymis fat weight0.21.22.01.1-1.1-1.31.3-1.41.2-1.30.90.2-1.1-1.10.4
Delta time in closed arm before/after self-admin1.01.01.90.6-0.6-0.80.9-1.01.0-1.10.7-0.7-1.4-1.41.0
Delta time in open arm before/after self-admin0.50.61.2-0.50.50.7-0.80.8-0.80.9-0.50.61.11.1-0.7
Diff in mean of infusions in LGA sessions0.10.10.4-0.30.30.1-0.1-0.10.0-0.20.3-0.7-0.5-0.50.6
Delay discount exponential model param0.50.71.50.5-0.5-0.80.9-0.91.0-1.01.2-0.1-1.0-1.00.6
Extinction: sum of active levers before priming2.13.25.3-1.51.62.1-2.22.3-2.12.2-1.7-0.51.91.8-0.4
Active lever presses in extinction session 60.30.30.6-0.20.20.7-0.70.6-0.70.7-0.6-0.10.60.7-0.2
Bone: final force1.72.83.81.8-1.8-2.02.0-1.91.9-1.91.80.6-1.5-1.50.3
Bone: final moment1.62.53.51.6-1.6-1.81.8-1.81.8-1.91.70.3-1.6-1.60.6
Food consumed during 24 hour testing period0.40.91.51.2-1.2-1.11.0-0.91.0-0.70.91.2-0.2-0.3-0.8
Glucose1.82.84.42.1-2.1-2.12.0-1.91.9-1.71.61.3-1.0-1.1-0.5
Heart weight0.50.81.71.3-1.2-1.11.1-1.20.9-1.00.50.5-0.7-0.7-0.3
Delay discount hyperbolic model param0.40.51.20.4-0.4-0.60.7-0.70.9-0.81.1-0.2-0.9-0.90.6
Intermittent access intake day 1-15 change0.21.21.81.0-1.0-1.11.2-1.21.1-1.21.40.0-1.2-1.20.6
Intermittent access intake escalation0.21.22.00.9-0.9-1.11.1-1.21.1-1.21.4-0.2-1.3-1.30.8
Intermittent access intake escalation 21.52.54.30.9-0.9-1.41.5-1.51.6-1.82.1-0.7-2.0-2.01.8
Intermitt. access day 1 inactive lever presses0.11.22.71.6-1.6-1.31.3-1.01.0-0.90.61.1-0.5-0.5-0.9
Intermitt. access day 15 inactive lever presses0.00.10.30.5-0.5-0.30.20.1-0.0-0.00.30.40.10.1-0.2
Intermitt. access escalation Index0.10.41.21.1-1.0-0.80.7-0.60.5-0.50.40.6-0.1-0.2-0.3
Intermittent access day 1 total infusions1.13.35.4-1.51.41.9-2.02.2-2.02.2-1.50.52.32.3-1.3
Intermittent access day 15 total infusions0.00.00.4-0.10.00.0-0.00.1-0.0-0.00.70.10.10.00.0
Intermittent access terminal intake (last 3 days)0.10.21.40.1-0.1-0.10.10.10.1-0.11.20.60.20.1-0.2
Intermittent access total infusions0.20.20.7-0.20.10.2-0.20.4-0.20.40.50.80.70.6-0.6
Intermittent access day 1 locomotion1.42.64.0-1.41.41.7-1.81.9-1.81.9-1.50.32.02.0-1.1
Intermittent access day 15 total locomotion0.52.02.7-1.41.41.5-1.51.6-1.51.6-1.30.01.61.6-0.8
Intermittent access total locomotion1.41.73.2-1.81.71.5-1.51.5-1.31.3-0.8-0.61.11.00.0
Intermittent access standard deviation0.00.30.50.7-0.7-0.60.6-0.30.4-0.40.70.6-0.1-0.2-0.3
Left kidney weight0.22.04.82.0-2.0-1.41.3-1.11.1-0.71.12.20.20.2-1.9
Right kidney weight0.21.22.31.5-1.5-1.31.3-1.31.2-1.00.91.0-0.5-0.5-0.8
Cocaine induced anxiety0.00.10.2-0.50.40.2-0.20.4-0.00.10.3-0.10.10.10.3
Post-drug Anxiety0.40.51.20.7-0.8-0.80.7-0.60.8-0.50.91.1-0.1-0.1-0.5
Baseline Anxiety0.40.71.21.0-1.0-1.01.0-1.10.9-0.90.70.4-0.7-0.7-0.1
Tail length1.16.19.33.0-3.0-2.92.9-2.82.7-2.52.71.8-1.6-1.7-0.5
Length with tail1.14.79.93.1-3.1-2.42.3-2.01.9-1.52.02.9-0.2-0.3-1.9
Length without tail0.20.92.50.8-0.80.0-0.20.4-0.40.60.01.61.31.2-1.6
Times rat made contact with spout0.50.60.90.6-0.6-0.80.8-0.80.8-0.90.9-0.1-1.0-1.00.5
Lifetime Intake0.50.71.9-0.1-0.00.3-0.40.7-0.50.70.61.41.21.1-1.2
Liver weight, left0.10.10.40.0-0.00.2-0.20.1-0.20.4-0.50.40.50.5-0.6
Liver weight, right0.50.81.6-1.31.31.1-1.11.1-0.80.8-0.4-0.90.30.30.8
Locomotor activity0.00.00.00.1-0.1-0.10.1-0.00.0-0.10.1-0.1-0.0-0.10.2
Locomotor testing distance0.20.51.2-0.30.20.5-0.60.9-0.70.8-0.50.51.11.0-0.7
Locomotor testing rearing0.20.81.81.0-1.1-1.11.0-0.60.9-0.71.31.1-0.2-0.3-0.5
Locomotion in novel chamber0.20.30.9-0.90.80.5-0.40.2-0.20.1-0.4-0.9-0.4-0.30.7
Locomotion in novel chamber post-restriction0.92.74.90.7-0.8-1.51.7-1.91.9-2.01.6-0.7-2.2-2.21.6
Fecal boli incidents, locomotor time 10.30.81.9-1.21.21.0-1.00.7-1.00.7-1.4-1.10.20.30.4
Change in fecal boli incidents, locomotor task0.50.51.51.0-1.0-0.70.6-0.50.5-0.30.41.20.30.2-1.1
Time >=10cm from walls, locomotor time 10.40.52.10.6-0.6-0.0-0.10.3-0.30.5-0.21.20.90.9-1.4
Bouts of movement, locomotor time 11.11.52.4-1.61.61.5-1.41.3-1.31.2-1.2-1.10.70.70.6
Total resting periods, locomotor time 11.61.83.5-1.91.91.6-1.51.3-1.31.1-1.2-1.60.40.41.0
Rest time, locomotor task time 11.21.97.2-1.71.70.9-0.70.1-0.3-0.2-0.5-2.7-1.3-1.12.4
Distance moved, locomotor task time 10.72.06.22.0-2.0-1.21.1-0.70.7-0.30.92.50.70.6-2.0
Vertical activity count, locomotor time 10.31.87.31.4-1.5-0.70.5-0.2-0.00.30.32.71.41.3-2.3
Time >=10cm from walls, locomotor time 20.00.10.40.4-0.4-0.20.2-0.00.10.0-0.20.60.20.2-0.6
Bouts of movement, locomotor time 20.10.40.60.6-0.6-0.80.8-0.60.7-0.70.80.5-0.4-0.50.0
Total resting periods, locomotor time 20.00.10.30.1-0.2-0.40.4-0.30.4-0.40.50.1-0.3-0.30.2
Rest time, locomotor task time 20.50.81.9-1.41.41.0-0.90.7-0.70.5-0.5-1.30.10.10.9
Distance moved, locomotor task time 20.60.81.10.8-0.8-1.01.0-1.00.9-1.00.80.0-1.0-1.00.5
Vertical activity count, locomotor time 20.20.51.21.0-1.1-0.90.8-0.70.5-0.50.31.1-0.1-0.1-0.7
Light reinforcement 10.62.910.91.9-1.9-0.90.70.20.20.40.43.31.81.7-3.0
Light reinforcement 21.22.89.31.1-1.1-0.0-0.20.5-0.61.1-0.33.02.42.3-3.0
Bone: marrow area0.92.23.61.9-1.9-1.71.6-1.71.4-1.31.51.6-0.5-0.5-1.0
Bone: maximum diameter2.34.66.82.2-2.2-2.52.5-2.62.3-2.52.40.7-2.0-2.00.4
Bone: maximum force2.95.87.82.6-2.6-2.82.8-2.72.7-2.72.70.9-2.1-2.20.4
Bone: maximum moment2.65.06.52.3-2.3-2.52.6-2.52.5-2.62.50.6-2.2-2.20.7
Mean time between licks in bursts0.10.30.5-0.70.70.6-0.60.5-0.60.5-0.7-0.50.30.30.1
Mean num. licks in bursts0.92.43.4-1.81.81.8-1.81.6-1.71.6-1.8-1.21.01.10.3
Cd content in liver0.80.81.41.2-1.2-1.11.1-1.01.0-0.91.10.7-0.4-0.5-0.2
Co content in liver0.70.81.5-0.50.50.8-0.91.0-0.91.1-0.90.51.21.2-1.1
Cu content in liver1.21.42.4-1.51.61.4-1.41.2-1.31.1-1.1-1.20.50.60.6
Fe content in liver1.11.42.3-0.70.71.1-1.21.4-1.21.4-1.10.61.51.5-1.1
K content in liver0.60.61.1-0.30.30.6-0.70.7-0.80.9-0.80.51.01.0-0.9
Mg content in liver0.80.91.7-1.01.01.0-1.10.8-1.11.0-1.3-0.30.90.9-0.4
Mn content in liver1.41.62.51.0-0.9-1.31.3-1.51.4-1.51.6-0.2-1.4-1.40.7
Na content in liver0.80.91.6-1.21.21.2-1.11.0-1.10.9-0.8-0.90.60.60.3
Rb content in liver4.04.76.6-2.52.52.6-2.62.5-2.52.4-2.3-0.91.81.9-0.2
Se content in liver2.32.74.31.6-1.6-1.81.9-1.91.9-1.92.10.4-1.6-1.70.6
Sr content in liver0.20.10.40.6-0.6-0.50.4-0.40.3-0.30.00.2-0.1-0.1-0.3
Zn content in liver0.10.10.30.2-0.2-0.30.3-0.50.3-0.4-0.1-0.4-0.5-0.50.5
Bone: minimum diameter0.10.10.4-0.20.20.00.0-0.30.0-0.30.0-0.6-0.5-0.40.6
Time in familiar zone, hab. session 11.51.76.7-1.01.00.3-0.1-0.20.2-0.70.3-2.4-1.6-1.62.6
Time in novel zone, hab. session 13.13.56.7-0.80.81.5-1.61.8-1.92.2-1.91.32.62.6-2.4
Total zone transitions, hab. session 10.00.00.00.1-0.1-0.10.1-0.20.0-0.1-0.1-0.2-0.1-0.10.0
Total locomotion distance, hab. session 10.91.32.60.4-0.4-0.91.0-1.11.0-1.30.9-1.0-1.6-1.61.4
Locomotion velocity, hab. session 11.82.63.91.3-1.3-1.71.8-1.91.8-2.01.6-0.4-1.9-1.91.1
Time in familiar zone, hab. session 20.80.93.5-1.11.10.6-0.50.4-0.3-0.1-0.4-1.9-0.8-0.81.8
Time in novel zone, hab. session 22.12.34.5-0.80.81.3-1.51.6-1.51.9-1.21.02.12.1-1.7
Total zone transitions, hab. session 20.50.72.01.1-1.1-0.80.7-0.60.5-0.20.31.30.30.3-1.4
Total locomotion distance, hab. session 20.60.81.21.1-1.1-1.11.1-1.11.0-1.00.80.6-0.7-0.7-0.3
Locomotion velocity, hab. session 20.81.11.71.2-1.2-1.31.3-1.31.2-1.21.00.6-0.9-0.9-0.2
Novel to familiar place preference ratio3.24.15.9-1.71.72.2-2.22.3-2.42.4-2.20.12.32.4-1.3
Novelty place preference3.95.07.0-2.12.12.5-2.52.6-2.62.6-2.4-0.22.42.4-1.1
Time in novel zone, NPP test5.06.18.4-2.32.32.7-2.82.8-2.92.9-2.6-0.32.62.7-1.2
Total zone transitions, NPP test0.60.92.41.3-1.3-0.90.8-0.50.6-0.30.41.50.40.4-1.5
Total locomotion distance, NPP test1.21.73.51.9-1.9-1.51.4-1.21.2-0.91.01.7-0.1-0.2-1.3
Locomotion velocity, NPP test1.62.34.32.1-2.1-1.91.8-1.61.5-1.31.31.6-0.5-0.6-1.0
Intraocular pressure1.52.44.12.0-2.0-1.91.8-1.61.6-1.41.51.8-0.5-0.6-0.8
Delta distance traveled before/after self-admin0.10.10.4-0.40.30.10.0-0.00.1-0.20.4-0.5-0.5-0.50.7
Delta ambulatory time before/after self-admin0.20.41.1-1.11.00.6-0.60.4-0.30.20.0-0.9-0.3-0.20.8
Parametrial fat weight0.20.61.60.1-0.00.3-0.40.8-0.60.8-1.00.71.01.0-1.3
Pavlov. Cond. lever latency5.26.610.3-3.23.23.1-3.02.8-2.82.5-2.9-2.21.51.60.9
Pavlov. Cond. magazine entry latency0.50.60.90.9-0.9-0.90.9-0.90.8-0.90.60.3-0.7-0.7-0.1
Pavlov. Cond. change in total contacts2.12.33.82.0-2.0-1.81.7-1.61.6-1.41.61.4-0.8-0.8-0.8
Pavlov. Cond. index score2.73.44.92.2-2.2-2.22.2-2.12.0-2.02.01.1-1.4-1.4-0.3
Pavlov. Cond. latency score2.43.14.52.1-2.1-2.12.1-2.01.9-1.82.01.2-1.2-1.3-0.4
Pavlov. Cond. lever contacts5.06.08.93.0-3.0-2.92.9-2.72.7-2.52.81.9-1.6-1.6-0.7
Pavlov. Cond. magazine entry number0.70.91.3-1.01.01.1-1.11.0-1.11.1-0.9-0.11.01.0-0.2
Pavlov. Cond. intertrial magazine entries0.20.30.40.5-0.5-0.50.6-0.70.5-0.60.60.1-0.5-0.50.2
Pavlov. Cond. lever-magazine prob. diff.2.93.65.02.1-2.1-2.22.2-2.12.1-2.12.10.9-1.6-1.6-0.0
Pavlov. Cond. response bias3.24.06.12.5-2.5-2.42.4-2.22.2-2.12.11.3-1.4-1.5-0.4
Pavlov. Cond. lever latency2.94.05.7-1.71.72.1-2.22.2-2.32.4-2.20.22.22.3-1.5
Pavlov. Cond. magazine entry latency0.20.20.8-0.50.50.4-0.30.4-0.20.1-0.1-0.8-0.3-0.30.9
Pavlov. Cond. change in total contacts1.22.95.80.7-0.7-1.31.5-1.61.7-2.01.4-1.4-2.4-2.42.3
Pavlov. Cond. index score0.81.22.80.3-0.3-0.80.9-0.91.0-1.31.0-1.1-1.6-1.61.7
Pavlov. Cond. latency score1.01.53.20.4-0.4-0.91.0-1.01.2-1.41.2-1.1-1.7-1.71.8
Pavlov. Cond. lever contacts2.23.24.61.4-1.4-1.81.9-1.92.0-2.12.0-0.4-2.1-2.11.5
Pavlov. Cond. magazine entry number0.91.23.4-0.10.10.6-0.70.6-0.91.1-0.91.31.61.6-1.8
Pavlov. Cond. intertrial magazine entries0.10.20.40.6-0.6-0.60.5-0.60.4-0.40.40.6-0.1-0.1-0.5
Pavlov. Cond. lever-magazine prob. diff.0.91.43.30.3-0.3-0.80.9-0.91.1-1.31.0-1.2-1.7-1.71.8
Pavlov. Cond. response bias1.62.23.80.9-0.9-1.31.4-1.41.5-1.71.5-0.8-1.9-2.01.8
Time in closed arm before self-admin0.30.40.9-1.00.90.7-0.70.8-0.60.6-0.9-0.40.40.40.1
Time in closed arm after self-admin0.30.41.3-0.40.40.2-0.10.00.2-0.3-0.1-1.1-0.8-0.81.0
Time in open arm before self-admin0.81.02.31.5-1.5-1.00.9-0.90.6-0.50.61.40.10.1-1.2
Time in open arm after self-admin0.60.62.21.0-1.0-0.70.6-0.50.3-0.20.61.50.60.5-1.2
Bone: periosteal estimation1.53.65.22.2-2.2-2.22.2-2.32.1-2.02.21.0-1.5-1.5-0.1
Bone: periosteal perimeter0.40.91.61.3-1.3-1.11.0-1.00.9-0.70.91.1-0.2-0.3-0.8
Bone: post-yield work1.42.54.52.1-2.1-1.91.8-1.61.5-1.31.61.8-0.4-0.5-1.2
Progressive ratio test 1 active lever presses1.01.73.9-0.60.51.1-1.21.7-1.21.5-0.01.32.01.8-1.3
Progressive ratio test 1 breakpoint0.81.43.3-0.40.40.9-1.01.5-1.11.40.11.31.81.7-1.4
Progressive ratio test 1 inactive lever presses0.51.34.91.1-1.2-0.60.40.10.10.30.72.21.21.1-2.0
Progressive ratio test 2 active lever presses1.62.34.9-0.90.81.3-1.41.8-1.51.7-0.21.42.22.1-1.7
Progressive ratio test 2 breakpoint1.92.55.2-1.00.91.3-1.51.8-1.51.8-0.31.42.32.2-1.7
Progressive ratio test 2 inactive lever presses0.00.10.60.1-0.2-0.10.00.10.00.10.60.80.50.4-0.5
Incentive Sensitization - Responses0.30.81.4-0.60.50.7-0.71.0-0.70.90.31.11.21.1-1.1
Incentive Sensitization - Breakpoint0.40.81.5-0.70.60.7-0.81.0-0.81.00.21.01.21.2-1.0
Sum of active levers in priming session hrs 5-64.34.05.9-1.31.32.1-2.22.3-2.32.4-2.30.32.42.4-1.4
Progressive ratio0.00.10.30.0-0.00.1-0.10.0-0.10.2-0.50.20.30.3-0.3
Food seeking constrained by brief footshock4.65.811.03.2-3.2-2.82.6-2.12.3-1.82.63.3-0.3-0.5-1.8
Seeking ratio, punishment vs. effort0.92.04.21.7-1.7-1.61.6-1.31.5-1.32.11.4-0.6-0.7-0.5
Retroperitoneal fat weight0.21.02.0-1.41.41.1-1.01.0-0.90.6-1.1-1.4-0.10.00.9
Reaction time number correct0.00.20.70.2-0.3-0.20.1-0.10.10.1-0.30.80.50.5-0.8
Reaction time mean minus median0.42.97.10.5-0.4-0.91.1-1.41.3-1.81.2-2.0-2.5-2.52.7
Reaction time mean minus median AUC0.42.95.40.9-0.8-1.31.4-1.71.6-2.01.7-1.3-2.3-2.32.2
Reaction time num false alarms0.20.41.2-0.20.2-0.20.3-0.60.4-0.60.7-0.7-0.7-0.81.1
Reaction time num false alarms AUC0.20.51.10.6-0.6-0.70.7-0.90.8-0.81.00.1-0.6-0.70.5
Reaction time trials correct on left0.00.20.70.2-0.3-0.20.1-0.10.10.1-0.30.80.50.5-0.8
Reaction time trials on left0.00.20.60.1-0.2-0.10.0-0.0-0.00.2-0.40.70.50.5-0.8
Reaction time mean0.81.76.8-1.31.30.9-0.70.5-0.5-0.0-0.6-2.6-1.1-1.12.3
Reaction time mean AUC0.82.07.7-1.41.51.0-0.80.6-0.50.0-0.6-2.8-1.2-1.12.5
Median of all reaction times1.42.25.2-1.91.91.7-1.51.4-1.30.9-1.4-2.3-0.1-0.01.6
Reaction time omissions1.11.83.3-1.31.41.6-1.61.5-1.61.4-1.8-1.20.80.90.3
Reaction time false alarm rate0.20.31.1-0.20.2-0.00.1-0.30.1-0.40.6-0.8-0.6-0.61.1
Reaction time premature initiation rate1.42.14.1-1.81.81.7-1.61.6-1.61.1-1.3-2.00.20.31.3
Reaction time premature initiations0.51.52.1-1.51.51.4-1.31.4-1.41.1-1.4-1.40.40.50.8
Std. dev. reaction times0.61.97.2-0.30.4-0.20.3-0.60.5-1.10.4-2.4-2.0-2.02.7
Reaction time trials completed0.00.20.60.1-0.2-0.10.0-0.0-0.00.2-0.40.70.50.5-0.8
Reaction time trials AUC0.00.10.60.1-0.2-0.10.0-0.00.00.2-0.40.70.50.5-0.8
Run reversals in cocaine runway, females0.20.20.5-0.50.5-0.10.2-0.40.5-0.4-0.1-0.7-0.7-0.60.7
Run reversals in cocaine runway, males0.10.10.1-0.30.30.3-0.30.2-0.30.2-0.1-0.20.10.10.2
Latency to leave start box in cocaine runway0.50.71.11.0-1.0-1.01.0-0.91.0-0.91.00.3-0.8-0.80.1
Latency to leave start box in cocaine runway, F0.20.30.7-0.10.10.3-0.30.5-0.40.6-0.60.50.60.7-0.8
Latency to leave start box in cocaine runway, M2.22.13.91.7-1.7-1.71.7-1.51.5-1.52.00.9-1.0-1.10.1
Std. dev. time between licks in bursts0.20.30.6-0.80.80.7-0.60.5-0.60.5-0.5-0.60.20.20.4
Total sessions with >9 infusions0.81.03.00.3-0.30.3-0.40.9-0.60.80.91.71.51.3-1.5
Short access day 1 total inactive lever presses0.51.14.11.3-1.3-0.70.50.00.20.10.62.00.90.8-1.7
Short access day 10 total inactive lever presses0.10.91.41.1-1.1-1.21.2-1.01.1-1.10.70.2-0.9-1.00.4
Short access day 1 total infusions0.71.34.00.6-0.60.1-0.30.9-0.50.90.72.01.71.5-1.8
Short access day 10 total infusions0.81.33.20.1-0.10.5-0.71.2-0.91.1-0.41.51.81.7-1.8
Short access total infusions1.31.84.5-0.20.10.8-0.91.5-1.11.40.21.82.11.9-1.9
Short access day 1 locomotion1.42.44.2-0.80.81.5-1.62.0-1.81.8-1.50.52.01.9-1.2
Short access day 10 total locomotion0.20.91.9-1.41.31.1-1.01.0-0.80.7-0.6-1.10.30.30.8
Short access total locomotion0.60.92.0-0.40.40.9-1.01.2-1.11.1-0.80.51.41.3-0.9
One hour access (0.3 mA shock)0.40.41.50.1-0.10.1-0.20.1-0.10.40.51.20.90.9-1.2
Compulsive drug intake0.30.41.10.0-0.0-0.60.6-0.90.7-0.80.2-0.4-1.1-1.00.3
One hour access (shock baseline)0.41.23.10.2-0.20.4-0.60.9-0.81.10.01.61.81.7-1.6
Social response proportion1.21.52.8-1.61.61.4-1.31.0-1.31.0-1.7-1.50.10.30.6
Social responses0.50.71.10.9-0.9-1.11.1-1.10.9-0.90.70.5-0.7-0.7-0.2
Social time0.00.10.2-0.00.00.1-0.10.2-0.20.2-0.40.20.20.2-0.4
Soleus weight0.82.37.60.8-0.70.2-0.40.7-0.91.3-1.12.32.12.1-2.8
Bone: stiffness3.86.99.32.9-2.9-3.03.1-3.03.0-2.93.01.1-2.2-2.30.4
Tibialis anterior weight6.020.635.35.9-5.9-5.45.3-4.84.9-4.34.84.0-2.4-2.6-1.7
Time to tail flick, vehicle, before self-admin0.50.61.4-1.11.10.8-0.80.5-0.50.5-1.0-1.20.00.10.7
Time to tail flick, vehicle, after self-admin0.00.10.20.0-0.1-0.20.2-0.20.2-0.30.4-0.2-0.3-0.40.5
Time to tail flick, test, before self-admin0.30.30.70.3-0.4-0.70.6-0.90.8-0.70.70.5-0.5-0.5-0.1
Time to tail flick, test, after self-admin2.62.74.70.9-1.0-1.71.8-2.21.9-2.11.1-0.6-2.2-2.11.3
Delta time to tail flick, vehicle, before/after SA0.20.20.50.6-0.6-0.60.6-0.40.4-0.50.70.5-0.3-0.3-0.2
Delta time to tail flick, test, before/after SA0.20.30.9-0.20.3-0.10.2-0.30.3-0.4-0.2-0.9-0.8-0.80.9
Tibia length0.30.83.10.5-0.5-0.1-0.00.3-0.20.5-0.11.61.21.1-1.8
Ambulatory time before self-admin1.03.07.52.7-2.7-1.91.8-1.31.3-1.21.82.2-0.2-0.3-1.3
Ambulatory time after self-admin0.50.82.21.2-1.2-0.90.9-0.70.8-0.71.50.8-0.4-0.5-0.4
Bone: tissue strength0.20.20.30.4-0.5-0.50.5-0.50.5-0.50.30.1-0.5-0.50.1
Total heroin consumption2.12.55.1-0.60.61.5-1.61.9-1.82.0-1.10.82.32.2-1.4
Bone: trabecular number1.12.03.01.1-1.1-1.41.5-1.71.6-1.71.4-0.3-1.6-1.71.2
Bone: trabecular spacing0.10.10.2-0.00.0-0.10.2-0.10.2-0.30.4-0.4-0.5-0.50.4
Bone: trabecular thickness0.20.20.7-0.60.60.4-0.30.1-0.30.1-0.2-0.9-0.2-0.20.8
Bone: trabecular tissue density2.23.95.82.4-2.4-2.42.3-2.02.2-2.02.41.4-1.3-1.4-0.2
Water consumed over 24 hours0.51.01.71.0-1.0-1.11.1-1.11.2-1.11.30.5-0.9-0.90.0
Number of responses in last shaping day2.33.07.70.5-0.50.6-0.81.5-1.51.7-0.92.32.62.4-2.8