Hub : Genes

Vars2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Vars2 0.13 0.06 0.0e+00 0.19 0.17 0.19 0.18 2.2e-27 1.3e-25 9.7e-28 8.5e-27
2 IL gene expression Vars2 0.27 0.13 3.2e-05 0.13 0.16 0.13 0.17 5.3e-04 1.1e-04 4.4e-04 7.2e-05
3 Liver gene expression Vars2 0.07 0.05 9.2e-06 0.04 0.04 0.04 0.04 1.0e-05 4.5e-05 3.2e-05 5.3e-05
4 OFC gene expression Vars2 0.25 0.13 1.2e-04 0.07 0.11 0.09 0.12 1.0e-02 1.4e-03 4.7e-03 8.7e-04
5 Brain gene expression Vars2 0.33 0.12 0.0e+00 0.26 0.29 0.28 0.28 5.2e-24 2.3e-27 4.4e-26 1.1e-25
6 PL gene expression Vars2 0.25 0.11 0.0e+00 0.3 0.31 0.31 0.32 1.4e-32 1.5e-34 1.9e-34 2.7e-35
7 BLA gene expression Vars2 0.17 0.13 1.8e-05 0.06 0.07 0.07 0.08 2.6e-04 1.4e-04 1.5e-04 7.1e-05
8 IC gene expression Vars2 0.17 0.08 4.2e-06 0.07 0.09 0.05 0.09 4.8e-04 1.1e-04 5.4e-03 1.1e-04
9 LHb gene expression Vars2 0.24 0.13 1.7e-04 0.14 0.15 0.14 0.1 2.8e-04 2.3e-04 4.0e-04 2.5e-03
10 pVTA gene expression Vars2 0.15 0.08 6.6e-13 0.15 0.11 0.16 0.13 4.3e-12 5.1e-09 7.8e-13 8.3e-11
11 Adipose gene expression Vars2 0.1 0.07 2.4e-10 0.08 0.08 0.09 0.08 8.8e-09 2.0e-09 6.9e-10 5.2e-09
12 Liver intron excision ratio chr20_3082389_3082524 0.04 0.04 6.0e-03 0.02 0.01 0.01 0.02 1.2e-03 1.3e-02 3.6e-02 6.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.01.73.31.01.70.70.81.21.31.61.10.71.21.7-1.8
Area under the delay curve1.71.92.5-1.3-1.5-1.5-1.5-1.5-1.3-1.5-1.5-1.6-1.4-1.40.4
BMI with tail1.55.26.6-2.6-2.1-2.4-2.4-2.5-2.6-1.8-2.5-2.5-2.0-2.2-1.6
BMI without tail3.510.613.2-3.6-3.3-3.4-3.5-3.5-3.6-3.0-3.5-3.4-3.3-2.9-1.3
Body weight5.724.933.8-5.3-5.7-4.9-4.8-5.0-5.6-5.4-5.2-4.6-5.8-5.00.1
Weight adjusted by age1.92.85.9-1.6-1.9-1.1-1.6-1.7-1.8-2.4-1.7-1.2-1.5-2.21.0
Bone surface0.00.10.4-0.2-0.3-0.2-0.2-0.1-0.3-0.4-0.2-0.1-0.6-0.20.4
Bone volume0.10.20.7-0.4-0.1-0.5-0.5-0.3-0.4-0.2-0.4-0.4-0.5-0.1-0.8
Breakpoint value in progressive ratio session0.30.40.80.70.60.50.80.60.60.40.70.70.90.3-0.0
Number of licking bursts0.60.95.60.90.20.81.00.70.80.40.80.90.30.22.4
Context. condit. distance diff. score7.49.012.03.32.73.43.43.53.02.63.33.52.62.81.3
Locomotion velocity, session 10.50.50.80.80.60.90.90.80.60.50.80.80.60.80.5
Locomotion distance, session 10.10.20.50.20.7-0.0-0.00.30.50.70.2-0.20.30.2-0.7
Locomotion velocity, session 20.10.10.20.30.00.40.30.20.2-0.10.20.20.1-0.10.4
Locomotion distance, session 20.20.30.50.60.70.40.40.70.70.50.50.20.60.3-0.2
Locomotion velocity, session 30.20.20.8-0.5-0.0-0.6-0.6-0.5-0.3-0.0-0.4-0.5-0.2-0.1-0.9
Locomotion distance, session 31.11.21.91.11.30.90.91.21.21.41.10.81.01.4-0.9
Stereotopy head waving bouts, day 31.31.53.2-0.9-1.6-0.7-0.7-1.0-1.2-1.8-0.9-0.7-1.2-1.41.8
Stereotopy head waving duration, day 31.01.22.4-0.9-1.4-0.8-0.8-1.0-1.1-1.5-0.9-0.6-1.0-1.21.5
Locomotion velocity, session 74.75.17.12.32.42.32.32.62.32.42.32.02.22.7-0.7
Locomotion distance, session 73.54.46.62.12.51.91.92.32.22.52.11.62.02.6-1.0
Stereotopy head waving bouts, day 72.83.14.9-1.7-2.1-1.6-1.6-1.8-1.9-2.2-1.8-1.8-1.8-1.70.7
Stereotopy head waving duration, day 72.73.25.1-1.8-2.1-1.7-1.7-1.8-2.0-2.2-1.8-1.7-1.9-1.70.6
Locomotion velocity, session 81.31.58.41.1-0.21.41.41.10.6-0.31.01.30.2-0.02.9
Locomotion distance, session 83.95.78.42.72.32.72.72.92.52.12.62.52.02.10.9
Degree of sensitization distance0.70.71.70.90.51.01.00.90.70.50.81.00.60.51.3
Degree of sensitization stereotypy1.31.41.9-1.2-1.3-1.1-1.1-1.2-1.3-1.4-1.2-1.3-1.2-1.00.3
Conditioned locomotion0.50.61.3-0.6-0.9-0.5-0.6-0.7-0.7-1.1-0.7-0.5-0.6-1.10.8
Cocaine response after cond. corrected0.40.50.90.80.90.60.60.80.91.00.70.60.60.70.2
Cocaine response after cond. not corrected0.10.11.40.1-0.30.20.20.0-0.0-0.30.00.2-0.3-0.21.2
Cocaine response before conditioning3.44.17.7-1.9-2.6-1.5-1.5-2.0-2.3-2.8-1.9-1.4-2.2-2.21.3
Saline control response2.23.04.2-2.0-1.3-2.1-2.0-2.0-1.8-1.2-1.9-1.8-1.3-0.8-2.0
Bone: connectivity density2.33.65.01.82.21.61.72.02.02.11.91.81.92.2-0.9
Bone: cortical apparent density0.60.82.7-0.9-0.3-1.1-1.1-1.0-0.6-0.4-0.9-1.1-0.4-0.6-1.6
Bone: cortical area1.62.43.3-1.6-1.7-1.5-1.5-1.5-1.6-1.7-1.6-1.6-1.8-1.60.2
Bone: cortical porosity0.70.71.1-0.8-0.9-0.9-0.9-1.0-0.9-0.8-0.9-0.9-0.9-0.80.3
Bone: cortical porosity0.50.61.0-0.6-1.0-0.5-0.6-0.8-0.7-0.8-0.6-0.5-0.8-0.81.0
Bone: cortical thickness3.96.510.8-2.7-2.0-2.9-3.0-2.7-2.4-2.0-2.8-3.3-2.4-2.1-1.8
Bone: cortical thickness1.51.83.6-1.5-0.8-1.5-1.7-1.4-1.2-0.5-1.5-1.8-0.8-0.7-1.9
Bone: cortical tissue density0.50.62.3-0.8-0.2-0.9-1.0-0.8-0.5-0.3-0.8-0.9-0.2-0.5-1.5
Condit. Reinf. active minus inactive responses0.91.01.51.11.20.90.91.01.10.91.00.91.11.2-0.3
Condit. Reinf. active-inactive response ratio0.00.10.3-0.2-0.0-0.2-0.2-0.3-0.2-0.1-0.2-0.20.10.0-0.5
Condit. Reinf. active responses1.51.83.01.41.61.21.21.31.51.41.31.11.41.7-0.8
Condit. Reinf. inactive responses2.02.44.11.42.01.11.11.51.71.91.41.01.52.0-1.6
Incentive salience index mean2.12.53.31.81.51.81.81.81.71.31.71.71.41.60.6
Condit. Reinf. lever presses3.75.37.32.62.02.62.62.72.31.82.52.51.92.21.1
Condit. Reinf. active minus inactive responses0.81.01.7-0.9-1.3-0.8-0.8-1.1-1.0-1.2-1.0-0.7-1.0-1.21.1
Condit. Reinf. active-inactive response ratio1.92.23.8-1.1-1.9-1.0-1.0-1.4-1.4-1.9-1.3-1.0-1.5-2.01.8
Condit. Reinf. active responses0.10.10.20.30.20.30.20.20.30.30.20.40.40.30.4
Condit. Reinf. inactive responses1.72.24.01.31.71.21.11.41.41.81.41.41.62.0-1.1
Condit. Reinf. lever presses0.81.11.51.11.01.01.01.01.01.11.11.21.21.10.2
Condit. Reinf. lever reinforcers received0.20.20.40.50.30.40.40.30.50.40.40.60.50.40.6
Conditioned reinforcement - actives1.22.02.9-1.4-1.2-1.5-1.6-1.4-1.3-1.4-1.4-1.7-1.6-1.5-0.6
Conditioned reinforcement - inactives1.52.23.1-1.5-1.3-1.8-1.7-1.6-1.3-1.5-1.5-1.7-1.5-1.5-0.5
Conditioned locomotion0.10.20.3-0.1-0.50.1-0.2-0.4-0.3-0.6-0.4-0.5-0.5-0.50.5
Patch foraging indifference point 0 sec0.71.22.6-1.5-0.6-1.5-1.6-1.3-0.9-0.4-1.1-1.1-0.5-0.4-1.5
Patch foraging indifference point AUC0.91.32.3-1.0-1.3-1.1-0.9-1.3-1.1-1.2-1.3-1.3-1.5-0.80.7
Delay disc. indifference point, 0s delay0.40.51.2-0.4-0.9-0.5-0.6-0.5-0.5-0.8-0.5-0.5-0.8-1.10.9
Delay disc. indifference point, 16s delay2.42.64.7-1.7-1.3-2.0-2.1-1.9-1.5-1.0-1.8-2.2-1.5-1.1-0.6
Delay disc. indifference point, 2s delay1.82.13.8-1.3-1.8-1.5-1.2-1.4-1.3-1.7-1.2-1.2-1.4-2.01.0
Delay disc. indifference point, 24s delay0.50.61.1-0.9-0.8-1.0-0.8-1.0-0.8-0.4-0.8-0.8-0.3-0.70.3
Delay disc. indifference point, 4s delay2.52.64.3-1.5-1.8-1.8-1.6-1.6-1.5-2.1-1.6-1.4-1.7-1.70.6
Delay disc. indifference point, 8s delay0.30.30.7-0.5-0.6-0.5-0.7-0.6-0.5-0.6-0.7-0.8-0.4-0.50.2
Indifference point function ln k0.30.60.90.80.41.00.70.80.70.60.80.80.70.70.9
Indifference point function log k0.30.60.90.80.41.00.70.80.70.60.80.80.70.70.9
Patch foraging total patch changes 0 sec0.91.73.3-1.7-0.8-1.8-1.8-1.5-1.1-0.5-1.3-1.4-0.7-0.5-1.5
Patch foraging total patch changes 12 sec1.31.63.1-1.6-0.9-1.6-1.8-1.5-1.2-0.6-1.4-1.5-0.9-0.7-1.0
Patch foraging total patch changes 18 sec0.81.25.4-1.0-0.1-1.3-1.2-1.0-0.60.5-0.9-1.2-0.60.2-2.3
Patch foraging total patch changes 24 sec0.40.75.1-0.40.6-0.6-0.7-0.30.10.9-0.2-0.60.40.8-2.3
Patch foraging total patch changes 6 sec1.21.83.3-1.7-0.8-1.8-1.8-1.5-1.2-0.4-1.3-1.5-0.7-0.4-1.6
Patch foraging time to switch 0 sec0.10.31.90.00.60.1-0.10.20.30.60.10.00.6-0.2-1.4
Patch foraging water rate 0 sec0.51.01.4-1.0-1.2-1.1-0.9-1.1-1.1-0.8-1.0-1.0-1.0-0.80.6
Patch foraging water rate 12 sec0.10.21.1-0.20.3-0.5-0.3-0.20.10.1-0.2-0.5-0.10.1-1.0
Patch foraging water rate 18 sec0.10.20.4-0.5-0.5-0.6-0.3-0.4-0.5-0.7-0.5-0.4-0.4-0.2-0.3
Patch foraging water rate 24 sec1.52.03.0-1.5-1.5-1.3-1.3-1.5-1.6-1.3-1.7-1.7-1.6-1.2-0.5
Patch foraging water rate 6 sec0.10.20.4-0.4-0.1-0.5-0.5-0.4-0.20.1-0.5-0.7-0.40.3-0.5
Seeking ratio, delayed vs. immediate footshock0.30.30.9-0.5-0.7-0.7-0.4-0.7-0.6-1.0-0.6-0.4-0.3-0.4-0.0
Distance traveled before self-admin0.10.10.40.3-0.10.50.40.2-0.0-0.60.10.3-0.2-0.40.6
Distance traveled after self-admin0.80.92.2-0.8-1.0-1.1-0.6-0.9-1.0-1.5-0.8-0.5-1.3-1.20.5
Extensor digitorum longus weight0.00.10.30.2-0.00.30.30.30.00.00.30.5-0.30.20.5
Bone: elastic displacement0.50.50.9-0.8-0.5-1.0-0.8-0.8-0.7-0.4-0.7-0.9-0.6-0.3-0.8
Bone: elastic work2.43.24.0-1.9-1.8-2.0-1.9-1.9-1.9-1.8-1.9-2.0-1.9-1.6-0.0
Bone: endosteal estimation1.12.410.8-0.7-2.1-0.1-0.0-0.6-1.4-2.2-0.60.4-1.4-1.83.3
Bone: endosteal perimeter0.81.88.21.1-0.21.51.61.20.4-0.21.21.90.20.22.9
Epididymis fat weight3.411.829.8-3.8-1.5-4.1-4.2-3.6-2.8-0.9-3.5-4.3-1.6-2.3-5.5
Delta time in closed arm before/after self-admin0.40.41.0-0.6-1.0-0.4-0.6-0.7-0.7-0.8-0.7-0.6-0.4-0.70.1
Delta time in open arm before/after self-admin0.20.20.4-0.5-0.2-0.6-0.6-0.3-0.5-0.6-0.4-0.4-0.4-0.5-0.5
Diff in mean of infusions in LGA sessions3.34.06.42.32.51.92.02.02.42.22.11.62.51.2-0.5
Delay discount exponential model param1.82.02.41.41.51.51.51.51.31.51.51.61.31.4-0.4
Extinction: sum of active levers before priming0.40.50.80.80.50.20.80.60.90.40.80.80.8-0.00.8
Active lever presses in extinction session 60.10.10.9-0.00.3-0.3-0.2-0.00.00.40.0-0.20.30.2-0.9
Bone: final force6.09.611.6-3.4-3.2-3.3-3.4-3.2-3.4-2.9-3.3-3.4-3.2-3.0-0.6
Bone: final moment5.28.410.3-3.2-3.0-3.0-3.1-3.0-3.2-2.8-3.1-3.1-3.0-2.7-0.7
Food consumed during 24 hour testing period0.30.41.1-0.5-0.9-0.2-0.2-0.3-0.8-1.1-0.5-0.2-0.7-0.60.3
Glucose2.54.08.72.21.02.52.52.11.80.62.02.51.30.73.0
Heart weight2.03.04.1-1.8-1.9-1.6-1.6-2.0-1.9-1.6-1.8-1.7-1.8-1.81.2
Delay discount hyperbolic model param1.92.12.61.41.61.61.61.61.41.51.51.61.41.4-0.5
Intermittent access intake day 1-15 change0.10.21.00.30.50.60.30.30.30.30.20.30.01.0-0.2
Intermittent access intake escalation0.10.21.0-0.10.20.0-0.2-0.1-0.1-0.0-0.2-0.2-0.40.9-1.0
Intermittent access intake escalation 20.20.31.40.40.20.90.50.50.20.10.30.5-0.11.20.1
Intermitt. access day 1 inactive lever presses0.10.51.9-0.2-0.7-0.3-0.1-0.3-0.2-0.9-0.30.0-0.8-1.11.4
Intermitt. access day 15 inactive lever presses0.71.42.4-1.3-1.3-1.3-1.2-1.2-1.3-1.1-1.2-1.0-1.6-1.10.0
Intermitt. access escalation Index2.43.44.71.91.81.91.92.22.01.92.11.91.91.70.4
Intermittent access day 1 total infusions0.10.10.6-0.00.2-0.6-0.2-0.00.20.30.1-0.40.1-0.5-0.8
Intermittent access day 15 total infusions0.20.31.6-0.30.0-0.7-0.5-0.3-0.1-0.1-0.3-0.7-0.4-0.1-1.3
Intermittent access terminal intake (last 3 days)0.40.61.1-0.7-0.4-1.0-0.9-0.8-0.6-0.6-0.7-1.0-0.7-0.6-0.8
Intermittent access total infusions0.30.40.7-0.6-0.3-0.8-0.7-0.6-0.4-0.3-0.5-0.8-0.6-0.5-0.8
Intermittent access day 1 locomotion0.10.10.40.40.30.10.30.40.40.20.30.20.3-0.1-0.6
Intermittent access day 15 total locomotion0.71.22.3-1.0-1.2-0.9-1.1-1.0-1.1-1.5-1.2-1.1-1.5-1.0-0.2
Intermittent access total locomotion0.81.01.7-0.9-1.0-0.9-1.0-0.9-0.9-1.1-1.0-1.1-1.3-0.9-0.6
Intermittent access standard deviation1.43.04.1-1.8-1.5-1.6-1.8-2.0-1.8-1.9-2.0-2.0-1.7-1.6-0.6
Left kidney weight4.118.926.0-4.7-4.8-3.9-4.3-4.6-5.1-4.6-4.8-4.3-4.5-4.1-0.7
Right kidney weight4.420.025.7-4.8-4.9-4.2-4.5-4.6-5.1-4.9-4.8-4.3-4.8-4.4-0.7
Cocaine induced anxiety0.60.91.60.90.70.91.11.20.90.91.11.30.70.70.7
Post-drug Anxiety0.70.71.30.70.60.90.80.90.71.10.91.10.90.80.5
Baseline Anxiety0.20.20.80.30.50.50.0-0.00.40.90.30.20.80.50.0
Tail length2.811.119.5-3.2-4.2-2.7-2.7-3.0-3.6-4.3-3.0-2.2-4.4-3.32.3
Length with tail3.916.929.1-3.9-5.2-3.4-3.4-3.6-4.5-5.3-3.8-2.8-5.4-4.32.4
Length without tail3.912.419.6-3.5-4.3-3.0-2.9-3.2-3.9-4.4-3.4-2.7-4.1-4.21.7
Times rat made contact with spout0.91.04.10.31.20.20.20.50.61.40.60.20.91.6-2.0
Lifetime Intake0.60.71.2-0.8-0.7-1.1-1.0-0.8-0.7-0.7-0.8-1.1-0.9-1.0-0.7
Liver weight, left0.40.62.60.1-0.80.40.50.3-0.4-1.20.20.9-0.4-0.81.6
Liver weight, right1.42.45.5-1.0-2.1-0.6-0.6-0.9-1.5-2.3-1.0-0.4-1.6-2.12.3
Locomotor activity0.30.51.9-0.1-1.10.60.3-0.0-0.8-0.9-0.10.6-0.50.31.4
Locomotor testing distance0.20.31.30.3-0.40.70.50.3-0.10.10.20.7-0.00.81.1
Locomotor testing rearing0.10.20.8-0.2-0.90.40.1-0.1-0.6-0.4-0.20.3-0.2-0.20.7
Locomotion in novel chamber0.60.81.3-1.0-0.9-0.7-1.1-0.9-0.9-0.9-1.0-1.0-1.1-0.1-0.1
Locomotion in novel chamber post-restriction0.91.53.1-1.4-1.2-1.4-1.8-1.3-1.2-1.1-1.2-1.1-1.2-0.9-0.4
Fecal boli incidents, locomotor time 10.40.60.90.61.0-0.10.90.70.80.90.90.80.80.4-0.6
Change in fecal boli incidents, locomotor task1.11.13.6-0.8-1.2-0.6-0.7-0.9-0.9-0.9-0.9-0.8-1.0-1.41.9
Time >=10cm from walls, locomotor time 10.60.62.0-0.6-1.0-0.4-0.3-0.4-0.9-1.1-0.30.1-0.8-1.40.9
Bouts of movement, locomotor time 11.11.31.91.11.01.21.11.30.91.21.21.31.21.40.0
Total resting periods, locomotor time 10.50.61.00.70.60.70.81.00.60.70.91.00.80.90.2
Rest time, locomotor task time 10.10.10.3-0.0-0.30.10.30.1-0.2-0.50.10.40.1-0.00.5
Distance moved, locomotor task time 10.60.91.6-1.0-0.8-1.2-1.0-1.1-0.9-0.9-1.0-1.1-1.2-0.9-0.3
Vertical activity count, locomotor time 10.20.40.8-0.7-0.6-0.3-0.7-0.7-0.7-0.4-0.7-0.8-0.9-0.3-0.8
Time >=10cm from walls, locomotor time 20.20.31.10.1-0.50.50.50.0-0.2-0.30.20.50.4-0.81.1
Bouts of movement, locomotor time 20.10.20.6-0.1-0.70.60.20.1-0.6-0.8-0.00.30.1-0.10.4
Total resting periods, locomotor time 20.20.31.00.3-0.61.00.60.5-0.3-0.60.30.70.40.20.8
Rest time, locomotor task time 21.11.42.81.20.41.71.41.40.70.21.21.70.90.61.5
Distance moved, locomotor task time 21.61.93.1-1.6-0.9-1.8-1.6-1.5-1.2-0.9-1.4-1.6-1.3-1.4-1.1
Vertical activity count, locomotor time 20.20.20.7-0.6-0.2-0.2-0.6-0.5-0.3-0.1-0.5-0.5-0.5-0.3-0.8
Light reinforcement 10.10.20.5-0.5-0.2-0.6-0.7-0.5-0.2-0.1-0.5-0.7-0.4-0.7-0.3
Light reinforcement 20.40.61.6-0.7-0.9-0.4-0.6-0.6-0.7-1.2-0.7-0.5-0.8-1.30.3
Bone: marrow area1.12.310.2-0.7-2.1-0.1-0.1-0.7-1.4-2.2-0.60.4-1.4-1.73.2
Bone: maximum diameter0.40.74.90.1-0.80.40.50.2-0.3-0.80.10.4-0.7-0.52.2
Bone: maximum force4.47.99.4-3.0-2.9-2.9-3.0-2.8-3.1-2.9-3.0-2.9-3.0-2.8-0.3
Bone: maximum moment3.86.78.3-2.8-2.7-2.6-2.7-2.6-2.9-2.7-2.7-2.7-2.7-2.6-0.3
Mean time between licks in bursts0.51.33.21.30.41.51.51.20.8-0.01.11.40.50.61.8
Mean num. licks in bursts0.71.110.5-0.70.4-0.6-0.8-0.4-0.40.4-0.5-0.70.20.7-3.2
Cd content in liver0.10.21.5-0.10.2-0.1-0.10.10.0-0.10.0-0.10.6-0.0-1.2
Co content in liver1.11.32.0-1.3-0.9-1.4-1.3-1.3-1.1-0.8-1.2-1.3-0.6-1.3-0.8
Cu content in liver1.51.83.80.91.80.50.61.01.41.91.00.51.31.7-1.9
Fe content in liver0.91.11.7-1.2-0.7-1.2-1.2-1.1-1.0-0.6-1.1-1.2-0.8-0.5-1.3
K content in liver0.10.10.60.20.40.00.10.20.30.80.1-0.2-0.10.5-0.2
Mg content in liver1.31.41.71.31.01.21.31.31.21.31.21.20.60.91.3
Mn content in liver3.43.86.02.21.42.22.32.21.91.42.12.41.31.42.1
Na content in liver0.60.61.7-0.8-0.4-1.0-0.9-0.9-0.5-0.2-0.9-1.3-0.9-0.3-0.4
Rb content in liver1.01.22.61.01.21.00.91.21.11.61.01.00.81.3-0.2
Se content in liver1.21.45.21.30.41.31.51.11.00.21.21.50.60.42.3
Sr content in liver0.40.30.7-0.5-0.8-0.4-0.4-0.4-0.6-0.8-0.4-0.2-0.6-0.70.7
Zn content in liver0.10.10.20.30.20.40.40.40.20.30.30.40.20.20.2
Bone: minimum diameter0.40.75.10.1-0.90.50.50.2-0.4-1.00.10.6-0.6-0.52.3
Time in familiar zone, hab. session 12.22.24.91.11.80.80.81.11.41.91.10.71.81.8-2.2
Time in novel zone, hab. session 11.01.03.1-0.7-1.3-0.4-0.4-0.7-1.0-1.4-0.7-0.2-1.2-1.31.8
Total zone transitions, hab. session 10.50.71.10.91.00.80.80.91.11.00.90.70.81.0-0.0
Total locomotion distance, hab. session 10.30.40.60.60.80.50.50.70.80.80.60.30.60.7-0.1
Locomotion velocity, hab. session 10.10.10.20.20.40.10.10.30.40.40.2-0.10.30.3-0.0
Time in familiar zone, hab. session 20.20.31.90.10.40.10.10.20.20.40.20.10.60.5-1.4
Time in novel zone, hab. session 20.20.20.3-0.4-0.4-0.3-0.4-0.5-0.5-0.4-0.4-0.3-0.6-0.50.5
Total zone transitions, hab. session 20.00.00.2-0.10.0-0.2-0.2-0.10.1-0.0-0.2-0.4-0.1-0.30.4
Total locomotion distance, hab. session 20.60.81.30.91.10.70.71.01.11.10.90.61.00.80.1
Locomotion velocity, hab. session 20.70.91.61.01.10.80.81.11.21.11.00.61.00.90.3
Novel to familiar place preference ratio0.10.10.2-0.20.0-0.4-0.4-0.3-0.00.1-0.2-0.4-0.3-0.10.1
Novelty place preference0.20.20.3-0.4-0.2-0.5-0.5-0.5-0.3-0.2-0.4-0.5-0.5-0.30.3
Time in novel zone, NPP test0.20.30.4-0.5-0.4-0.6-0.6-0.6-0.4-0.3-0.5-0.6-0.7-0.50.4
Total zone transitions, NPP test0.91.42.11.31.41.11.11.31.41.31.21.01.11.00.1
Total locomotion distance, NPP test0.60.81.50.91.20.70.71.01.11.20.90.50.90.8-0.4
Locomotion velocity, NPP test1.21.62.91.31.71.01.01.41.61.71.30.81.31.3-0.5
Intraocular pressure0.91.32.11.11.21.21.21.10.81.11.01.01.50.9-1.4
Delta distance traveled before/after self-admin2.22.33.5-1.7-1.5-1.9-1.6-1.7-1.5-1.5-1.5-1.4-1.6-1.40.1
Delta ambulatory time before/after self-admin1.31.62.2-1.4-1.5-1.4-1.2-1.4-1.4-1.3-1.2-1.1-1.2-1.20.3
Parametrial fat weight1.12.53.8-1.8-1.4-1.6-1.9-1.4-1.7-1.4-1.6-1.5-1.9-1.0-1.5
Pavlov. Cond. lever latency1.62.03.5-1.7-0.8-1.9-1.9-1.6-1.3-0.5-1.5-1.5-0.7-1.1-1.8
Pavlov. Cond. magazine entry latency2.43.04.62.01.22.12.11.91.61.01.92.11.41.61.5
Pavlov. Cond. change in total contacts0.20.31.70.1-0.50.30.30.0-0.1-0.7-0.00.1-0.6-0.21.3
Pavlov. Cond. index score2.73.45.42.11.22.32.32.11.70.91.92.11.21.61.9
Pavlov. Cond. latency score2.02.54.21.90.92.12.11.81.40.61.61.80.81.32.0
Pavlov. Cond. lever contacts1.41.73.81.50.61.71.71.41.10.31.31.40.50.82.0
Pavlov. Cond. magazine entry number3.13.95.6-2.2-1.6-2.3-2.3-2.1-1.8-1.4-2.1-2.4-1.8-1.9-1.2
Pavlov. Cond. intertrial magazine entries0.50.65.2-0.10.8-0.4-0.4-0.10.30.8-0.1-0.30.50.5-2.3
Pavlov. Cond. lever-magazine prob. diff.3.03.75.72.21.42.42.42.21.81.02.12.21.41.71.7
Pavlov. Cond. response bias3.24.06.02.31.52.42.42.21.81.22.12.41.61.81.5
Pavlov. Cond. lever latency0.30.40.9-0.5-0.7-0.4-0.4-0.5-0.6-0.7-0.5-0.6-0.9-0.60.6
Pavlov. Cond. magazine entry latency0.30.30.6-0.4-0.7-0.4-0.4-0.4-0.5-0.8-0.5-0.4-0.8-0.60.8
Pavlov. Cond. change in total contacts0.10.20.4-0.5-0.5-0.5-0.6-0.6-0.4-0.3-0.5-0.5-0.4-0.50.3
Pavlov. Cond. index score0.00.00.10.1-0.00.10.00.00.1-0.10.10.10.1-0.00.3
Pavlov. Cond. latency score0.00.00.1-0.1-0.2-0.2-0.3-0.2-0.1-0.2-0.2-0.1-0.1-0.30.2
Pavlov. Cond. lever contacts0.10.20.50.30.40.30.20.30.30.50.30.40.70.4-0.5
Pavlov. Cond. magazine entry number0.30.30.60.50.60.50.60.50.60.70.50.50.60.8-0.3
Pavlov. Cond. intertrial magazine entries1.52.33.31.71.41.61.81.71.61.21.71.81.31.50.7
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.10.00.10.10.10.1-0.00.10.20.10.00.2
Pavlov. Cond. response bias0.20.20.30.50.40.50.50.50.40.40.50.60.60.40.1
Time in closed arm before self-admin0.10.10.30.30.50.40.20.30.40.50.30.40.10.30.5
Time in closed arm after self-admin0.80.91.6-0.9-1.0-0.4-1.1-1.2-1.0-0.7-1.1-1.3-0.9-0.7-0.3
Time in open arm before self-admin0.50.50.90.80.40.90.80.70.60.60.80.80.80.60.3
Time in open arm after self-admin0.30.30.70.50.50.40.60.70.30.20.70.80.70.10.4
Bone: periosteal estimation1.42.95.9-1.4-2.3-1.0-0.9-1.3-1.8-2.4-1.4-0.7-1.9-2.02.1
Bone: periosteal perimeter0.40.73.1-0.3-1.1-0.1-0.0-0.3-0.7-1.2-0.4-0.0-1.0-0.91.8
Bone: post-yield work0.81.22.81.10.31.51.51.30.70.21.11.70.70.71.3
Progressive ratio test 1 active lever presses0.30.41.4-0.5-0.3-1.2-0.8-0.5-0.3-0.2-0.4-0.7-0.6-0.9-0.2
Progressive ratio test 1 breakpoint0.40.41.5-0.6-0.4-1.2-0.8-0.6-0.3-0.2-0.5-0.8-0.6-0.9-0.1
Progressive ratio test 1 inactive lever presses0.50.72.4-0.8-0.2-1.6-1.1-0.7-0.30.1-0.6-0.9-0.7-0.6-1.4
Progressive ratio test 2 active lever presses0.10.10.50.20.5-0.1-0.10.10.40.30.1-0.20.20.2-0.7
Progressive ratio test 2 breakpoint0.10.10.70.10.4-0.2-0.10.10.30.30.1-0.30.10.2-0.8
Progressive ratio test 2 inactive lever presses0.40.71.3-0.7-0.8-1.1-0.8-0.7-0.6-1.0-0.6-0.8-1.0-1.10.4
Incentive Sensitization - Responses0.40.60.90.90.90.70.80.81.00.60.80.60.70.9-0.5
Incentive Sensitization - Breakpoint0.50.61.10.91.00.70.80.81.00.60.80.50.71.0-0.6
Sum of active levers in priming session hrs 5-60.60.61.80.80.50.70.80.60.80.30.80.91.40.30.5
Progressive ratio5.28.111.4-3.1-2.9-3.4-3.1-3.0-3.0-2.9-2.9-2.8-2.9-2.6-0.2
Food seeking constrained by brief footshock0.10.10.60.20.4-0.10.20.20.20.40.20.20.10.8-0.4
Seeking ratio, punishment vs. effort4.66.68.62.82.62.92.92.62.62.82.62.62.62.50.2
Retroperitoneal fat weight0.52.02.9-1.5-1.3-1.4-1.7-1.2-1.5-1.3-1.5-1.5-1.7-1.2-1.1
Reaction time number correct0.30.61.4-0.9-0.4-1.0-0.9-0.9-0.70.1-0.9-0.9-0.5-0.2-1.2
Reaction time mean minus median0.51.42.81.30.41.51.71.60.8-0.11.31.60.71.10.3
Reaction time mean minus median AUC0.51.32.71.30.61.51.61.60.80.21.21.50.81.10.2
Reaction time num false alarms0.30.51.4-0.5-0.9-0.3-0.7-0.6-0.4-0.6-0.5-0.6-0.8-0.91.2
Reaction time num false alarms AUC0.60.92.4-0.7-1.1-0.5-0.8-0.8-0.6-0.9-0.7-0.8-1.1-1.11.5
Reaction time trials correct on left0.30.61.4-0.9-0.4-1.0-0.9-0.9-0.70.1-0.9-0.9-0.5-0.2-1.2
Reaction time trials on left0.30.61.3-0.9-0.4-1.0-0.9-0.9-0.70.1-0.9-0.9-0.5-0.2-1.1
Reaction time mean1.42.34.21.80.82.02.01.91.40.61.62.01.00.71.3
Reaction time mean AUC1.42.34.21.80.82.02.11.91.40.51.62.01.00.71.1
Median of all reaction times1.21.73.21.60.71.81.71.51.30.61.31.70.80.51.4
Reaction time omissions0.81.12.21.20.41.51.31.30.80.11.21.50.70.41.0
Reaction time false alarm rate0.40.64.7-0.1-0.70.1-0.2-0.2-0.1-0.8-0.1-0.1-0.6-0.92.2
Reaction time premature initiation rate1.72.33.0-1.6-1.7-1.7-1.5-1.6-1.6-1.3-1.6-1.5-1.6-1.70.6
Reaction time premature initiations2.03.55.1-2.1-1.9-2.3-2.1-2.1-2.0-1.3-2.0-2.0-1.8-1.8-0.1
Std. dev. reaction times0.61.22.41.20.11.51.51.40.7-0.21.11.50.50.41.3
Reaction time trials completed0.30.61.3-0.9-0.4-1.0-0.9-0.9-0.70.1-0.9-0.9-0.5-0.2-1.1
Reaction time trials AUC0.30.51.3-0.9-0.3-0.9-0.8-0.8-0.70.2-0.8-0.8-0.5-0.1-1.1
Run reversals in cocaine runway, females0.20.20.6-0.30.1-0.8-0.4-0.4-0.1-0.1-0.3-0.60.1-0.3-0.6
Run reversals in cocaine runway, males0.50.51.9-0.4-1.1-0.3-0.2-0.1-0.8-1.4-0.3-0.1-0.8-1.00.8
Latency to leave start box in cocaine runway0.20.20.90.4-0.11.00.60.30.10.40.30.20.50.10.6
Latency to leave start box in cocaine runway, F0.70.82.60.90.41.61.00.80.60.90.80.80.90.90.3
Latency to leave start box in cocaine runway, M0.80.71.4-0.9-0.9-0.7-0.6-0.9-0.9-0.9-0.9-1.0-0.8-1.20.4
Std. dev. time between licks in bursts0.91.28.40.9-0.21.11.20.70.4-0.30.81.20.2-0.32.9
Total sessions with >9 infusions0.60.71.4-0.8-0.7-1.2-0.9-0.9-0.7-0.7-0.8-1.1-1.0-0.8-0.3
Short access day 1 total inactive lever presses1.52.03.3-1.2-1.8-1.3-1.1-1.2-1.4-1.8-1.3-1.2-1.7-1.70.9
Short access day 10 total inactive lever presses0.10.20.50.60.60.10.70.60.70.30.50.40.20.3-0.5
Short access day 1 total infusions0.00.10.40.0-0.2-0.1-0.2-0.1-0.1-0.2-0.1-0.30.2-0.6-0.1
Short access day 10 total infusions0.50.61.2-0.8-0.4-1.1-0.9-0.7-0.5-0.6-0.7-1.0-0.9-0.7-0.6
Short access total infusions0.81.01.7-0.9-0.9-1.2-1.2-1.0-0.8-0.8-1.0-1.3-1.0-1.2-0.5
Short access day 1 locomotion0.91.12.11.31.30.71.11.21.51.01.20.91.10.60.2
Short access day 10 total locomotion0.20.43.0-0.0-0.60.30.0-0.3-0.2-0.8-0.20.2-0.4-0.71.7
Short access total locomotion0.10.11.00.2-0.1-0.10.00.00.3-0.20.10.1-0.2-0.41.0
One hour access (0.3 mA shock)1.11.21.91.21.31.11.01.21.41.11.20.81.11.2-0.4
Compulsive drug intake3.94.76.02.42.02.22.42.42.41.82.42.32.11.71.7
One hour access (shock baseline)0.50.83.0-0.9-0.5-0.8-1.0-0.8-0.8-0.6-0.8-1.0-0.8-0.4-1.7
Social response proportion0.20.31.6-0.1-0.5-0.2-0.0-0.1-0.2-0.50.00.3-0.3-0.81.3
Social responses0.40.51.4-0.6-0.8-0.6-0.5-0.7-0.6-0.5-0.5-0.3-0.7-0.91.2
Social time0.70.95.10.8-0.31.11.00.80.3-0.50.71.00.00.22.3
Soleus weight0.72.018.30.4-0.90.60.80.4-0.0-0.70.51.1-0.8-1.04.3
Bone: stiffness1.01.52.1-1.4-1.1-1.3-1.4-1.2-1.3-1.1-1.3-1.4-1.1-1.1-1.1
Tibialis anterior weight0.20.82.3-0.9-0.2-1.1-1.1-0.9-0.70.1-0.9-1.1-0.70.1-1.5
Time to tail flick, vehicle, before self-admin1.31.42.41.21.21.31.11.31.21.21.21.10.81.5-0.6
Time to tail flick, vehicle, after self-admin0.81.11.61.20.81.21.11.21.00.81.21.20.81.00.7
Time to tail flick, test, before self-admin0.10.10.8-0.00.30.10.10.30.20.30.20.10.20.9-0.7
Time to tail flick, test, after self-admin1.11.12.31.11.01.51.01.00.90.80.90.90.91.4-1.0
Delta time to tail flick, vehicle, before/after SA0.00.00.10.10.1-0.00.10.1-0.00.20.1-0.10.10.1-0.3
Delta time to tail flick, test, before/after SA0.40.40.70.70.90.80.60.50.70.80.50.40.70.4-0.7
Tibia length1.33.76.9-1.7-2.6-1.1-1.2-1.6-2.2-2.6-1.6-0.9-2.2-2.42.1
Ambulatory time before self-admin0.10.10.50.0-0.10.2-0.0-0.0-0.1-0.7-0.1-0.1-0.4-0.40.1
Ambulatory time after self-admin1.11.32.7-1.0-1.4-1.2-0.9-1.1-1.2-1.7-1.0-0.8-1.4-1.40.3
Bone: tissue strength4.64.66.2-2.3-2.2-2.3-2.1-2.2-2.4-2.2-2.3-2.3-2.5-2.0-0.3
Total heroin consumption0.00.00.2-0.0-0.1-0.40.10.10.0-0.10.20.2-0.1-0.20.3
Bone: trabecular number1.01.64.00.91.70.60.61.11.31.60.90.51.11.8-2.0
Bone: trabecular spacing2.93.96.1-1.8-2.5-1.6-1.5-2.0-2.2-2.4-1.9-1.5-2.1-2.41.6
Bone: trabecular thickness1.01.33.40.91.50.80.71.01.11.20.90.71.21.2-1.8
Bone: trabecular tissue density1.52.32.9-1.5-1.7-1.4-1.5-1.6-1.6-1.6-1.5-1.6-1.5-1.70.6
Water consumed over 24 hours0.00.10.4-0.1-0.20.10.00.0-0.20.00.10.1-0.20.00.7
Number of responses in last shaping day1.11.24.7-0.6-1.2-0.8-0.6-0.9-0.8-1.0-0.7-0.6-0.9-1.62.2