Hub : Genes

Utp25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	isoform ratio	XM_063272402.1	0.02	0.01	7.1e-03	0.01	0	0.01	0.01	4.1e-02	4.6e-02	9.1e-03	8.1e-03
2	NAcc	isoform ratio	NM_001013986.2	0.02	0.01	5.0e-03	0.01	0.01	0.01	0.01	3.4e-02	4.2e-02	8.4e-03	6.0e-03
3	NAcc	gene expression	Utp25	0.03	0.02	8.4e-04	0.01	0.01	0.01	0.01	8.5e-03	2.5e-03	1.7e-02	2.9e-02
4	Brain	mRNA stability	Utp25	0.06	0.04	4.6e-06	0.06	0.06	0.04	0.05	3.4e-06	3.5e-06	1.0e-04	1.4e-05
5	PL	mRNA stability	Utp25	0.03	0.02	1.7e-03	0.01	0.01	0	0.01	3.4e-02	2.0e-02	7.5e-02	5.6e-02
6	Adipose	mRNA stability	Utp25	0.06	0.04	6.1e-07	0.06	0.04	0.04	0.04	5.2e-07	3.3e-05	1.7e-05	9.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.3	0.6	1.5	0.7	-0.7	-1.2	-0.1	0.3	0.9
Area under the delay curve	0.1	0.1	0.1	0.1	-0.1	-0.4	-0.3	-0.2	0.4
BMI with tail	0.1	0.3	0.5	0.7	-0.7	-0.7	-0.5	-0.3	0.3
BMI without tail	1.1	3.3	5.3	2.3	-2.3	-2.2	-1.7	-1.0	0.6
Body weight	3.2	13.8	25.1	5.0	-5.0	-4.2	-3.1	-1.5	1.6
Weight adjusted by age	1.5	2.3	4.5	1.8	-1.8	-2.1	-1.0	0.1	1.3
Bone surface	0.5	0.8	1.2	1.1	-1.1	-1.1	-0.0	0.6	1.0
Bone volume	0.4	0.7	1.6	1.0	-1.0	-1.2	-0.6	-0.1	0.7
Breakpoint value in progressive ratio session	0.6	0.7	1.4	1.2	-1.2	-0.8	-0.7	-0.4	0.1
Number of licking bursts	0.7	1.2	3.3	0.8	-0.8	-1.0	0.7	1.1	1.8
Context. condit. distance diff. score	1.1	1.3	2.6	1.3	-1.3	-1.6	-0.1	0.5	1.3
Locomotion velocity, session 1	0.5	0.5	1.5	0.4	-0.4	-0.0	0.9	1.2	0.7
Locomotion distance, session 1	1.6	2.0	3.0	1.7	-1.7	-1.7	-0.1	0.8	1.7
Locomotion velocity, session 2	0.2	0.3	0.5	0.6	-0.6	-0.6	-0.1	0.2	0.7
Locomotion distance, session 2	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.3	-0.1	0.2
Locomotion velocity, session 3	1.8	2.1	3.1	1.8	-1.8	-1.2	-1.7	-1.3	-0.1
Locomotion distance, session 3	1.3	1.4	3.6	0.1	-0.2	0.0	-1.7	-1.9	-1.3
Stereotopy head waving bouts, day 3	1.4	1.6	4.3	0.5	-0.5	-0.1	1.7	2.1	1.5
Stereotopy head waving duration, day 3	2.2	2.6	6.3	0.6	-0.6	-0.4	2.0	2.5	2.2
Locomotion velocity, session 7	2.0	2.2	4.6	-0.2	0.2	0.9	-1.7	-2.1	-2.1
Locomotion distance, session 7	2.2	2.8	6.1	-1.0	1.0	1.3	-1.5	-2.2	-2.5
Stereotopy head waving bouts, day 7	1.8	2.1	3.2	1.6	-1.5	-1.2	0.8	1.6	1.8
Stereotopy head waving duration, day 7	2.6	3.1	5.8	1.4	-1.4	-1.3	1.5	2.2	2.4
Locomotion velocity, session 8	1.2	1.4	3.1	0.4	-0.4	-0.8	1.4	1.8	1.6
Locomotion distance, session 8	1.0	1.5	2.5	1.3	-1.3	-1.5	-0.0	0.7	1.6
Degree of sensitization distance	0.6	0.6	0.9	-1.0	1.0	0.8	0.8	0.5	-0.3
Degree of sensitization stereotypy	0.5	0.5	0.7	0.8	-0.8	-0.7	0.3	0.6	0.8
Conditioned locomotion	0.9	1.0	1.9	-1.0	1.0	0.9	1.4	1.0	0.3
Cocaine response after cond. corrected	0.5	0.6	1.3	-0.5	0.5	0.4	1.1	1.1	0.6
Cocaine response after cond. not corrected	1.1	1.3	3.2	-0.1	0.1	-0.1	1.6	1.8	1.5
Cocaine response before conditioning	0.6	0.8	1.3	0.9	-0.9	-1.2	0.2	0.7	1.1
Saline control response	0.4	0.6	1.2	0.6	-0.6	-1.1	-0.8	-0.7	0.7
Bone: connectivity density	1.1	1.8	3.9	1.0	-1.1	-1.6	0.6	1.3	2.0
Bone: cortical apparent density	0.3	0.3	0.9	-0.5	0.5	0.6	-0.2	-0.5	-1.0
Bone: cortical area	1.3	2.0	3.5	1.9	-1.9	-1.7	-1.2	-0.5	0.7
Bone: cortical porosity	0.8	0.8	1.8	-0.3	0.3	-0.4	1.3	1.3	1.2
Bone: cortical porosity	0.6	0.6	1.3	-0.4	0.3	-0.3	1.1	1.1	0.9
Bone: cortical thickness	0.4	0.7	1.1	1.0	-1.0	-1.1	0.0	0.5	0.9
Bone: cortical thickness	1.5	1.8	3.2	1.6	-1.6	-1.8	-0.1	0.7	1.4
Bone: cortical tissue density	0.3	0.4	1.1	-0.6	0.6	0.7	-0.2	-0.5	-1.0
Condit. Reinf. active minus inactive responses	0.6	0.7	1.8	0.3	-0.3	-0.2	-1.3	-1.3	-0.9
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	0.5	0.4	-0.2	-0.3	-0.5
Condit. Reinf. active responses	1.8	2.2	5.0	1.2	-1.2	-1.0	-2.2	-1.9	-0.8
Condit. Reinf. inactive responses	1.7	2.1	3.0	1.7	-1.7	-1.6	-1.6	-1.1	0.3
Incentive salience index mean	1.4	1.7	4.2	0.8	-0.8	-0.7	-2.1	-1.9	-0.8
Condit. Reinf. lever presses	2.0	2.8	6.3	1.4	-1.4	-1.5	-2.5	-2.1	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.6	0.6	0.2	-0.4	-0.6	-0.5
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.5	-1.2	1.2	1.1	0.6	0.1	-0.7
Condit. Reinf. active responses	0.5	0.6	1.7	-0.1	0.1	-0.1	-1.2	-1.3	-0.8
Condit. Reinf. inactive responses	2.0	2.6	5.2	1.5	-1.6	-1.5	-2.3	-1.8	-0.2
Condit. Reinf. lever presses	0.6	0.8	1.9	0.5	-0.5	-0.7	-1.4	-1.3	-0.4
Condit. Reinf. lever reinforcers received	0.4	0.6	1.5	-0.1	0.1	-0.1	-1.1	-1.2	-0.8
Conditioned reinforcement - actives	0.6	1.1	2.0	1.2	-1.2	-1.0	0.1	0.6	1.4
Conditioned reinforcement - inactives	1.3	1.9	2.8	1.7	-1.6	-1.7	-0.2	0.5	1.7
Conditioned locomotion	2.3	3.0	5.4	2.0	-2.0	-2.0	-0.0	1.0	2.3
Patch foraging indifference point 0 sec	1.1	2.0	3.7	1.4	-1.4	-1.8	0.2	1.0	1.9
Patch foraging indifference point AUC	0.7	1.0	2.1	-1.1	1.1	1.4	0.2	-0.5	-1.2
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.5	-0.5	-0.3	0.1	0.3	0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.5	0.1	-0.2	-0.5	-0.0	0.1	0.7
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	0.1	-0.1	-0.7	-0.2	-0.1	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.1	0.1	-0.4	-0.4	-0.4	0.3
Delay disc. indifference point, 4s delay	0.7	0.7	1.5	0.7	-0.7	-0.7	-1.2	-1.0	-0.3
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	-0.8	0.8	0.6	0.5	0.2	-0.1
Indifference point function ln k	1.0	1.7	3.9	0.7	-0.7	-1.0	1.0	1.8	2.0
Indifference point function log k	1.0	1.7	3.9	0.7	-0.7	-1.0	1.0	1.8	2.0
Patch foraging total patch changes 0 sec	1.1	2.0	3.7	1.4	-1.4	-1.8	0.1	1.0	1.9
Patch foraging total patch changes 12 sec	0.6	0.8	1.4	1.2	-1.2	-1.1	-0.5	-0.0	0.8
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	0.7	-0.7	-0.4	-0.6	-0.4	-0.2
Patch foraging total patch changes 24 sec	0.3	0.5	1.0	0.6	-0.6	-0.6	-1.0	-0.9	-0.3
Patch foraging total patch changes 6 sec	0.3	0.5	0.7	0.8	-0.8	-0.7	-0.8	-0.6	0.1
Patch foraging time to switch 0 sec	0.5	1.0	2.0	1.4	-1.4	-0.8	-0.9	-0.5	-0.2
Patch foraging water rate 0 sec	0.9	1.8	3.0	-1.2	1.2	0.1	1.7	1.7	1.5
Patch foraging water rate 12 sec	0.7	1.5	2.7	-1.6	1.6	1.2	1.2	0.8	-0.2
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.4	0.4	0.3	0.5	0.6	0.2
Patch foraging water rate 24 sec	0.2	0.3	0.7	-0.3	0.3	0.3	0.7	0.8	0.5
Patch foraging water rate 6 sec	0.3	0.4	1.0	-0.2	0.2	-0.2	0.8	0.7	1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.3	-0.4	0.4	-0.2	-0.9	-1.1	-0.8
Distance traveled before self-admin	3.2	4.2	7.6	2.3	-2.3	-2.2	0.6	1.5	2.8
Distance traveled after self-admin	1.8	2.3	3.7	1.7	-1.7	-1.4	0.6	1.4	1.9
Extensor digitorum longus weight	0.5	1.8	4.0	0.3	-0.3	0.2	-1.8	-2.0	-1.9
Bone: elastic displacement	1.3	1.5	3.6	-0.2	0.2	-0.3	1.6	1.9	1.5
Bone: elastic work	0.8	1.1	2.5	0.3	-0.3	-0.6	1.2	1.6	1.4
Bone: endosteal estimation	0.1	0.3	0.7	0.5	-0.5	-0.1	-0.8	-0.7	-0.4
Bone: endosteal perimeter	0.7	1.4	3.2	1.1	-1.1	-0.7	-1.8	-1.5	-0.5
Epididymis fat weight	0.7	2.3	4.2	1.5	-1.5	-1.8	0.6	1.3	2.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	-0.7	0.7	0.7	0.2	-0.1	-0.5
Delta time in open arm before/after self-admin	2.2	2.2	4.4	1.2	-1.3	-1.0	-2.1	-1.9	-0.9
Diff in mean of infusions in LGA sessions	0.3	0.4	1.0	0.6	-0.6	-1.0	-0.2	0.1	0.7
Delay discount exponential model param	0.1	0.1	0.2	-0.1	0.1	0.5	0.4	0.3	-0.4
Extinction: sum of active levers before priming	2.6	2.8	4.5	2.1	-2.1	-1.9	-1.8	-1.1	0.2
Active lever presses in extinction session 6	3.5	3.5	7.0	2.6	-2.6	-2.2	-1.1	-0.2	1.1
Bone: final force	0.6	0.9	1.8	1.3	-1.3	-1.0	-0.0	0.5	0.8
Bone: final moment	0.6	0.9	1.9	1.4	-1.4	-1.1	-0.4	0.1	0.6
Food consumed during 24 hour testing period	0.4	0.5	1.0	0.8	-0.8	-0.4	0.3	0.8	1.0
Glucose	0.4	0.6	1.3	-0.5	0.5	0.5	1.1	1.1	0.6
Heart weight	0.7	1.2	1.7	1.3	-1.3	-1.2	-1.1	-0.9	0.1
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.3	0.3	0.6	0.5	0.4	-0.4
Intermittent access intake day 1-15 change	1.1	2.2	4.7	-1.3	1.3	1.7	2.2	1.6	-0.2
Intermittent access intake escalation	1.2	2.5	5.8	-1.3	1.3	1.6	2.4	1.9	0.1
Intermittent access intake escalation 2	1.4	1.6	3.9	-0.9	0.9	1.3	2.0	1.6	0.3
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.2	0.4	-0.4	0.1	-0.5	-0.5	-0.5
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.1	1.1	-1.1	-0.3	-1.0	-0.9	-0.7
Intermitt. access escalation Index	0.3	0.5	1.2	-0.3	0.3	0.6	-0.6	-0.9	-1.1
Intermittent access day 1 total infusions	1.2	2.0	3.3	1.8	-1.8	-1.7	-0.9	-0.2	1.3
Intermittent access day 15 total infusions	1.1	1.6	3.9	0.2	-0.2	0.1	1.8	2.0	1.4
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.4	0.4	-0.4	0.5	1.2	1.1	0.5
Intermittent access total infusions	0.7	0.8	1.6	0.7	-0.7	-0.5	0.8	1.1	1.3
Intermittent access day 1 locomotion	2.2	2.8	4.8	2.2	-2.2	-2.0	-0.8	0.2	1.5
Intermittent access day 15 total locomotion	1.3	2.4	3.5	1.9	-1.9	-1.4	0.5	1.3	1.8
Intermittent access total locomotion	2.1	2.5	3.8	2.0	-2.0	-1.8	-0.2	0.7	1.9
Intermittent access standard deviation	0.2	0.3	0.9	-0.5	0.5	0.9	0.7	0.3	-0.4
Left kidney weight	1.5	7.1	13.4	3.7	-3.7	-3.1	-1.6	-0.3	1.8
Right kidney weight	1.7	7.9	15.9	4.0	-4.0	-3.1	-1.3	0.1	2.0
Cocaine induced anxiety	1.2	1.7	3.5	0.9	-0.9	-0.2	-1.9	-1.9	-1.2
Post-drug Anxiety	0.3	0.3	0.7	0.2	-0.2	0.5	-0.5	-0.6	-0.9
Baseline Anxiety	3.7	4.2	9.1	-1.8	1.8	1.4	3.0	2.6	1.0
Tail length	2.8	11.1	18.5	4.3	-4.3	-3.7	-3.3	-2.0	0.8
Length with tail	4.3	18.5	34.1	5.8	-5.8	-4.7	-3.8	-1.9	1.5
Length without tail	2.0	6.4	12.5	3.5	-3.5	-2.8	-1.4	-0.1	1.8
Times rat made contact with spout	0.2	0.2	0.6	0.3	-0.3	-0.4	0.2	0.4	0.8
Lifetime Intake	0.8	1.0	2.0	0.9	-0.9	-0.8	0.6	1.1	1.4
Liver weight, left	0.4	0.7	1.1	1.1	-1.1	-1.1	-0.2	0.2	0.7
Liver weight, right	0.8	1.4	3.0	0.8	-0.8	-0.9	1.1	1.6	1.7
Locomotor activity	0.3	0.4	0.9	0.4	-0.4	0.0	0.9	1.0	0.7
Locomotor testing distance	0.0	0.0	0.1	0.1	-0.1	0.0	0.3	0.4	0.2
Locomotor testing rearing	0.1	0.1	0.3	-0.5	0.5	0.4	0.1	-0.1	-0.1
Locomotion in novel chamber	0.2	0.2	0.5	-0.4	0.4	0.6	-0.1	-0.4	-0.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1	0.1	0.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	0.0	-0.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.4	0.4	0.3	0.7	0.7	0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.4	-0.4	0.0	0.3	0.5	0.6
Bouts of movement, locomotor time 1	0.7	0.8	1.5	-0.7	0.7	0.4	1.2	1.2	0.9
Total resting periods, locomotor time 1	0.5	0.5	0.7	-0.7	0.7	0.5	0.8	0.8	0.6
Rest time, locomotor task time 1	0.8	1.0	1.5	-1.1	1.1	1.0	1.2	1.0	0.4
Distance moved, locomotor task time 1	0.6	0.9	2.2	1.5	-1.5	-0.9	-0.6	-0.1	0.3
Vertical activity count, locomotor time 1	0.1	0.3	0.7	0.5	-0.5	-0.7	0.3	0.5	0.8
Time >=10cm from walls, locomotor time 2	0.8	1.1	1.8	1.3	-1.3	-0.6	-1.3	-1.0	-0.2
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.5	0.5	0.2	0.1	0.2	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.3	0.3	0.1	-0.0	0.2	0.0
Rest time, locomotor task time 2	1.1	1.4	2.7	-1.4	1.4	1.6	1.0	0.6	-0.6
Distance moved, locomotor task time 2	2.0	2.4	4.6	2.1	-2.1	-1.9	-0.7	0.0	1.1
Vertical activity count, locomotor time 2	0.4	0.6	0.9	0.9	-0.9	-0.9	0.1	0.4	0.9
Light reinforcement 1	0.5	1.2	2.6	-0.5	0.5	0.1	1.6	1.6	1.2
Light reinforcement 2	1.2	1.9	5.0	-0.1	0.2	0.1	2.0	2.2	1.6
Bone: marrow area	0.1	0.2	0.5	0.4	-0.4	-0.0	-0.7	-0.6	-0.4
Bone: maximum diameter	0.6	1.1	1.7	1.3	-1.3	-1.1	-1.2	-0.8	0.2
Bone: maximum force	1.0	1.8	3.0	1.7	-1.7	-1.4	0.2	1.1	1.4
Bone: maximum moment	1.0	1.8	3.3	1.8	-1.8	-1.5	-0.1	0.7	1.2
Mean time between licks in bursts	0.3	0.8	1.8	-0.1	0.1	0.6	-1.1	-1.3	-1.4
Mean num. licks in bursts	0.5	0.8	2.2	-0.6	0.6	0.8	-0.7	-1.0	-1.5
Cd content in liver	7.0	7.8	11.9	3.3	-3.3	-3.5	-3.0	-1.8	0.8
Co content in liver	1.3	1.5	3.3	0.4	-0.4	-0.7	1.3	1.8	1.8
Cu content in liver	3.2	3.8	6.5	-2.6	2.6	2.5	1.3	0.2	-1.5
Fe content in liver	2.5	3.1	5.0	-2.2	2.2	2.2	0.8	-0.2	-1.6
K content in liver	0.8	0.7	1.5	-1.0	1.0	1.2	0.6	0.1	-0.7
Mg content in liver	0.6	0.6	1.2	0.5	-0.5	-0.7	0.6	1.0	1.1
Mn content in liver	0.1	0.2	0.4	0.3	-0.3	-0.7	-0.4	-0.4	-0.1
Na content in liver	2.0	2.2	4.2	-1.8	1.8	2.0	0.9	0.0	-1.1
Rb content in liver	1.3	1.5	2.4	-1.6	1.6	1.5	0.5	-0.2	-1.1
Se content in liver	0.4	0.4	0.8	0.6	-0.6	-0.6	0.3	0.7	0.9
Sr content in liver	1.3	1.1	2.8	-0.2	0.2	0.1	-1.4	-1.7	-1.3
Zn content in liver	5.1	5.6	9.6	2.5	-2.5	-3.0	0.4	1.7	3.1
Bone: minimum diameter	1.3	2.3	5.5	0.7	-0.7	-0.7	-2.3	-2.3	-1.4
Time in familiar zone, hab. session 1	1.2	1.1	2.4	-0.3	0.3	0.9	-1.1	-1.5	-1.5
Time in novel zone, hab. session 1	0.8	0.8	1.6	1.2	-1.2	-1.2	-0.2	0.3	0.7
Total zone transitions, hab. session 1	1.0	1.4	2.8	1.7	-1.7	-1.3	-0.7	0.2	1.0
Total locomotion distance, hab. session 1	0.8	1.2	1.8	1.3	-1.3	-0.8	0.3	1.0	1.3
Locomotion velocity, hab. session 1	1.0	1.4	2.8	1.1	-1.1	-0.8	0.7	1.4	1.7
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.5	-0.5	-0.3	-0.7	-0.5	-0.1
Time in novel zone, hab. session 2	0.2	0.2	0.3	0.5	-0.5	-0.4	-0.6	-0.4	-0.0
Total zone transitions, hab. session 2	1.4	1.8	2.9	1.7	-1.7	-1.7	-1.0	-0.3	1.0
Total locomotion distance, hab. session 2	0.9	1.2	2.3	1.5	-1.5	-1.2	-0.6	0.1	1.0
Locomotion velocity, hab. session 2	0.7	1.0	1.6	1.3	-1.2	-1.1	-0.3	0.4	1.1
Novel to familiar place preference ratio	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2	0.2	0.3
Novelty place preference	0.1	0.2	0.3	0.5	-0.5	-0.5	0.1	0.3	0.4
Time in novel zone, NPP test	0.1	0.1	0.3	0.5	-0.5	-0.5	-0.0	0.1	0.3
Total zone transitions, NPP test	1.8	2.6	4.4	2.0	-2.0	-2.1	-0.5	0.5	1.6
Total locomotion distance, NPP test	1.0	1.4	2.5	1.6	-1.6	-1.4	-0.5	0.3	1.1
Locomotion velocity, NPP test	1.1	1.5	2.6	1.6	-1.6	-1.4	-0.5	0.3	1.2
Intraocular pressure	0.2	0.3	0.8	-0.2	0.2	0.1	0.7	0.9	0.6
Delta distance traveled before/after self-admin	0.3	0.3	0.8	-0.3	0.3	0.5	-0.4	-0.5	-0.9
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	-0.7	0.7	0.6	0.0	-0.1	-0.6
Parametrial fat weight	0.3	0.8	1.6	0.7	-0.6	-0.0	-1.2	-1.3	-0.8
Pavlov. Cond. lever latency	2.4	3.0	6.0	-1.5	1.5	2.0	2.5	1.9	-0.0
Pavlov. Cond. magazine entry latency	3.3	4.2	9.9	1.6	-1.6	-1.5	-3.1	-2.7	-1.0
Pavlov. Cond. change in total contacts	3.0	3.1	6.6	1.4	-1.4	-1.8	-2.6	-2.2	-0.4
Pavlov. Cond. index score	2.4	3.1	7.6	1.0	-1.0	-1.3	-2.8	-2.5	-0.9
Pavlov. Cond. latency score	2.7	3.5	8.3	1.2	-1.2	-1.6	-2.9	-2.6	-0.8
Pavlov. Cond. lever contacts	1.4	1.7	3.6	1.0	-1.0	-1.4	-1.9	-1.6	-0.2
Pavlov. Cond. magazine entry number	3.0	3.8	9.1	-1.3	1.3	1.1	3.0	2.8	1.2
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.9	0.0	-0.0	-0.2	1.3	1.4	1.2
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.8	6.7	1.1	-1.1	-1.5	-2.6	-2.3	-0.6
Pavlov. Cond. response bias	2.7	3.3	7.5	1.4	-1.4	-1.4	-2.7	-2.4	-0.8
Pavlov. Cond. lever latency	0.9	1.2	1.8	-1.1	1.2	1.3	1.3	0.9	-0.4
Pavlov. Cond. magazine entry latency	0.9	1.0	2.4	1.1	-1.1	-1.6	-0.7	-0.2	1.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	-0.8	0.8	0.5	-0.0	-0.4	-0.5
Pavlov. Cond. index score	0.9	1.2	2.5	1.1	-1.1	-1.6	-1.0	-0.6	0.7
Pavlov. Cond. latency score	0.8	1.1	2.3	1.0	-1.0	-1.5	-1.1	-0.7	0.6
Pavlov. Cond. lever contacts	0.6	0.9	1.4	1.0	-1.0	-1.2	-1.1	-0.8	0.3
Pavlov. Cond. magazine entry number	0.3	0.3	1.1	-0.4	0.5	1.1	0.2	-0.0	-0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	0.2	-0.2	0.1	-0.7	-0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.1	1.0	-1.0	-1.4	-0.8	-0.4	0.7
Pavlov. Cond. response bias	1.1	1.5	2.3	1.4	-1.4	-1.5	-1.3	-0.8	0.5
Time in closed arm before self-admin	0.1	0.1	0.3	0.0	-0.0	-0.1	0.4	0.5	0.5
Time in closed arm after self-admin	0.9	0.9	2.1	-0.6	0.6	0.8	1.4	1.4	0.6
Time in open arm before self-admin	0.2	0.2	0.4	0.5	-0.5	-0.6	-0.4	-0.2	0.2
Time in open arm after self-admin	2.0	2.2	5.0	0.9	-0.9	-0.9	-2.2	-2.2	-1.2
Bone: periosteal estimation	0.7	1.4	2.3	1.5	-1.5	-1.2	-1.4	-0.8	0.1
Bone: periosteal perimeter	1.1	1.8	2.8	1.7	-1.7	-1.3	-1.6	-1.0	0.3
Bone: post-yield work	0.1	0.1	0.4	-0.1	0.1	0.1	0.5	0.6	0.2
Progressive ratio test 1 active lever presses	0.7	0.8	1.4	1.2	-1.2	-0.8	-1.0	-0.6	0.2
Progressive ratio test 1 breakpoint	0.6	0.7	1.4	1.2	-1.2	-0.8	-0.9	-0.5	0.2
Progressive ratio test 1 inactive lever presses	1.1	1.5	2.3	1.4	-1.4	-0.8	-1.5	-1.4	-0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.7	-0.7	-0.3	-0.3	-0.2	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.6	-0.6	-0.2	-0.2	-0.1	0.2
Progressive ratio test 2 inactive lever presses	1.2	2.0	3.6	1.9	-1.9	-1.7	-0.4	0.4	1.3
Incentive Sensitization - Responses	0.1	0.1	0.2	0.4	-0.4	-0.2	0.0	0.1	0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.4	-0.4	-0.1	0.0	0.0	0.1
Sum of active levers in priming session hrs 5-6	3.7	3.4	6.5	2.5	-2.5	-2.1	-1.5	-0.5	0.7
Progressive ratio	3.0	4.7	12.1	1.2	-1.2	-2.4	1.3	2.4	3.5
Food seeking constrained by brief footshock	0.4	0.5	0.7	-0.7	0.7	0.7	-0.3	-0.7	-0.8
Seeking ratio, punishment vs. effort	2.7	3.8	9.6	-1.1	1.2	2.1	-1.2	-2.2	-3.1
Retroperitoneal fat weight	1.3	5.4	9.2	3.0	-3.0	-3.0	-1.2	0.0	1.9
Reaction time number correct	0.2	0.4	1.0	-0.5	0.5	-0.2	-0.6	-1.0	-0.4
Reaction time mean minus median	0.8	2.0	4.9	-0.5	0.5	0.5	2.2	2.2	1.2
Reaction time mean minus median AUC	0.6	1.5	3.5	-0.8	0.8	1.1	1.9	1.6	0.6
Reaction time num false alarms	2.4	3.3	6.1	-2.5	2.5	2.3	0.8	-0.2	-1.4
Reaction time num false alarms AUC	1.9	2.9	5.2	-2.3	2.3	2.2	0.9	0.1	-1.2
Reaction time trials correct on left	0.2	0.4	1.0	-0.5	0.5	-0.2	-0.6	-1.0	-0.4
Reaction time trials on left	0.2	0.3	0.8	-0.5	0.5	-0.3	-0.5	-0.9	-0.3
Reaction time mean	0.8	1.3	3.4	-0.2	0.2	0.7	1.8	1.8	0.9
Reaction time mean AUC	1.0	1.6	3.9	-0.5	0.5	0.8	2.0	2.0	0.9
Median of all reaction times	0.4	0.6	1.4	-0.2	0.2	0.8	1.2	1.2	0.4
Reaction time omissions	1.7	2.5	5.9	0.3	-0.3	-0.6	1.8	2.3	2.4
Reaction time false alarm rate	1.1	1.5	3.3	-1.4	1.4	1.8	0.8	0.4	-0.9
Reaction time premature initiation rate	0.2	0.2	0.6	-0.1	0.1	0.6	-0.3	-0.5	-0.8
Reaction time premature initiations	0.2	0.4	0.7	-0.5	0.5	0.6	-0.3	-0.7	-0.9
Std. dev. reaction times	1.7	3.2	8.5	0.0	-0.0	0.2	2.6	2.9	2.0
Reaction time trials completed	0.2	0.3	0.8	-0.5	0.5	-0.3	-0.5	-0.9	-0.3
Reaction time trials AUC	0.2	0.4	1.1	-0.5	0.5	-0.3	-0.7	-1.0	-0.4
Run reversals in cocaine runway, females	0.3	0.3	0.8	-0.2	0.2	0.9	-0.0	-0.3	-0.8
Run reversals in cocaine runway, males	0.4	0.4	0.8	-0.6	0.6	0.7	0.9	0.6	0.1
Latency to leave start box in cocaine runway	1.1	1.2	2.5	-1.6	1.6	1.2	0.6	0.1	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.7	1.2	-1.1	1.1	0.7	0.9	0.8	-0.1
Latency to leave start box in cocaine runway, M	0.7	0.7	1.1	-0.9	0.9	1.0	-0.1	-0.7	-1.0
Std. dev. time between licks in bursts	0.5	0.7	1.6	0.5	-0.5	-0.2	-1.3	-1.3	-0.5
Total sessions with >9 infusions	1.0	1.2	2.2	1.5	-1.5	-1.4	-0.8	-0.2	0.7
Short access day 1 total inactive lever presses	0.4	0.6	1.4	1.2	-1.2	-0.6	-0.3	0.1	0.4
Short access day 10 total inactive lever presses	0.5	1.3	3.0	0.3	-0.4	0.1	-1.5	-1.7	-1.5
Short access day 1 total infusions	0.4	0.5	1.1	0.9	-0.9	-1.0	-0.6	-0.2	0.5
Short access day 10 total infusions	0.9	1.1	1.6	1.3	-1.3	-1.3	-0.3	0.2	1.3
Short access total infusions	1.1	1.4	2.3	1.4	-1.4	-1.5	-0.1	0.6	1.5
Short access day 1 locomotion	1.6	2.0	4.3	1.6	-1.6	-2.1	-1.0	-0.2	1.2
Short access day 10 total locomotion	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	0.2	0.1
Short access total locomotion	0.8	1.0	1.6	1.1	-1.1	-1.2	-0.2	0.4	1.2
One hour access (0.3 mA shock)	0.3	0.3	0.7	0.8	-0.8	-0.6	-0.3	-0.2	0.3
Compulsive drug intake	1.4	1.7	4.0	-0.2	0.2	0.5	-1.4	-1.9	-2.0
One hour access (shock baseline)	0.8	1.2	2.5	0.6	-0.6	-0.4	1.2	1.5	1.6
Social response proportion	0.1	0.1	0.1	-0.4	0.4	0.1	-0.3	-0.2	-0.1
Social responses	0.3	0.3	0.9	-0.3	0.3	-0.3	-0.9	-0.9	-0.2
Social time	0.0	0.0	0.1	-0.3	0.3	-0.0	-0.0	-0.2	0.0
Soleus weight	1.3	3.9	7.9	-1.5	1.5	0.5	2.8	2.7	1.9
Bone: stiffness	0.8	1.4	3.1	1.8	-1.8	-1.2	-0.5	0.1	0.5
Tibialis anterior weight	0.6	1.9	4.2	0.7	-0.7	-0.3	-2.0	-2.0	-1.4
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.7	-0.8	0.8	0.8	0.8	0.6	-0.1
Time to tail flick, vehicle, after self-admin	0.8	1.0	1.8	1.3	-1.3	-1.2	-0.2	0.3	0.9
Time to tail flick, test, before self-admin	1.9	1.9	4.4	0.6	-0.6	-0.7	1.5	2.1	2.0
Time to tail flick, test, after self-admin	1.0	1.1	1.5	1.2	-1.2	-0.9	0.4	1.0	1.2
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	1.8	1.3	-1.3	-1.3	-0.5	-0.0	0.8
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.6	-0.6	-0.5	-0.8	-0.6	-0.1
Tibia length	1.0	2.7	4.6	1.8	-1.8	-1.5	-2.1	-1.6	-0.2
Ambulatory time before self-admin	2.3	3.5	7.3	1.8	-1.8	-1.9	0.8	1.6	2.7
Ambulatory time after self-admin	1.0	1.2	2.7	0.6	-0.6	-0.6	1.0	1.5	1.6
Bone: tissue strength	0.2	0.2	0.4	0.2	-0.2	0.7	0.5	0.6	-0.2
Total heroin consumption	3.1	3.7	6.3	2.5	-2.5	-2.4	-1.4	-0.4	1.1
Bone: trabecular number	0.3	0.5	1.3	0.1	-0.1	-0.7	0.6	0.8	1.2
Bone: trabecular spacing	0.5	0.7	1.0	1.0	-1.0	-0.4	-1.0	-0.7	-0.5
Bone: trabecular thickness	0.0	0.1	0.1	-0.4	0.4	-0.1	0.1	0.0	0.1
Bone: trabecular tissue density	1.0	1.5	4.8	-0.5	0.5	1.4	-0.6	-1.1	-2.2
Water consumed over 24 hours	0.3	0.4	1.4	0.3	-0.3	-0.4	0.4	0.6	1.2
Number of responses in last shaping day	0.2	0.2	0.6	-0.0	0.0	0.1	0.7	0.7	0.7