Uspl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	isoform ratio	NM_001105906.2	0.06	0.04	5.6e-03	0.04	0.04	0.05	0.04	6.4e-03	4.9e-03	3.7e-03	6.1e-03
2	Liver	isoform ratio	NM_001105906.2	0.03	0.02	3.8e-04	0.02	0.02	0.02	0.02	3.4e-03	1.3e-03	1.4e-03	2.0e-03
3	Adipose	mRNA stability	Uspl1	0.07	0.04	4.1e-10	0.06	0.06	0.06	0.07	1.1e-07	1.6e-07	1.0e-07	3.6e-08
4	Brain	mRNA stability	Uspl1	0.06	0.03	1.0e-08	0.11	0.09	0.09	0.1	5.0e-10	4.3e-09	4.3e-09	1.6e-09
5	PL	mRNA stability	Uspl1	0.03	0.02	2.3e-04	0.03	0.03	0.02	0.03	6.3e-04	3.4e-04	2.0e-03	7.0e-04
6	NAcc	mRNA stability	Uspl1	0.05	0.03	1.5e-04	0.01	0.04	0.03	0.03	7.3e-03	3.0e-05	1.0e-04	2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.8	4.7	9.9	2.9	-3.2	-2.1	1.6	-1.5	-0.4
Area under the delay curve	0.3	0.3	0.8	-0.7	0.9	0.5	-0.1	0.4	-0.1
BMI with tail	1.7	5.7	9.0	3.0	-2.9	-2.5	2.2	-2.0	-1.2
BMI without tail	0.5	1.0	1.5	-0.7	0.7	0.9	-1.1	1.2	1.2
Body weight	3.1	13.0	30.8	5.6	-4.2	-4.3	3.1	-0.8	0.9
Weight adjusted by age	0.9	1.1	3.1	-0.2	0.4	1.0	-0.9	1.2	1.8
Bone surface	2.1	3.6	7.5	2.7	-2.6	-2.0	1.6	-0.9	0.1
Bone volume	3.8	6.5	11.4	3.3	-3.4	-2.6	2.3	-2.0	-1.0
Breakpoint value in progressive ratio session	0.1	0.1	0.4	-0.3	0.6	0.1	-0.0	0.6	0.4
Number of licking bursts	0.6	0.7	1.8	-0.5	0.1	0.7	-1.1	0.9	1.3
Context. condit. distance diff. score	1.2	1.4	2.7	1.5	-1.1	-1.7	1.4	-0.6	-0.1
Locomotion velocity, session 1	0.9	0.9	1.6	-0.6	0.8	0.8	-1.0	1.2	1.3
Locomotion distance, session 1	1.4	1.8	2.8	-1.1	1.1	1.6	-1.7	1.2	1.2
Locomotion velocity, session 2	1.3	1.5	2.7	-0.5	0.6	1.4	-1.5	1.3	1.6
Locomotion distance, session 2	4.1	5.8	8.0	-1.9	1.9	2.7	-2.8	2.5	2.5
Locomotion velocity, session 3	0.6	0.7	1.0	1.0	-0.9	-0.9	1.0	-0.7	-0.6
Locomotion distance, session 3	0.2	0.2	0.4	-0.4	0.6	0.2	-0.3	0.6	0.2
Stereotopy head waving bouts, day 3	1.4	1.7	5.5	-0.4	0.5	0.8	-1.1	1.6	2.3
Stereotopy head waving duration, day 3	0.2	0.2	0.9	-0.2	0.1	0.4	-0.3	0.4	1.0
Locomotion velocity, session 7	0.1	0.1	0.2	-0.4	0.4	-0.1	0.2	-0.1	-0.2
Locomotion distance, session 7	0.2	0.3	0.8	-0.7	0.9	0.3	-0.3	0.3	-0.0
Stereotopy head waving bouts, day 7	2.7	3.0	4.2	-2.1	2.0	1.8	-1.7	1.6	1.1
Stereotopy head waving duration, day 7	1.0	1.3	1.8	-1.3	1.1	1.2	-1.2	1.0	0.8
Locomotion velocity, session 8	1.2	1.4	1.8	-0.9	1.2	1.2	-1.2	1.3	1.3
Locomotion distance, session 8	0.6	0.9	2.7	-0.1	0.2	0.6	-1.0	1.2	1.6
Degree of sensitization distance	0.2	0.2	0.4	-0.7	0.6	0.5	-0.4	0.2	0.2
Degree of sensitization stereotypy	0.7	0.8	1.4	-1.2	0.9	1.0	-0.9	0.6	0.2
Conditioned locomotion	0.9	1.1	2.0	-1.2	0.7	1.4	-1.4	0.5	0.6
Cocaine response after cond. corrected	0.9	1.0	3.0	0.0	-0.6	-0.4	0.7	-1.4	-1.7
Cocaine response after cond. not corrected	1.1	1.2	3.6	-0.0	-0.8	-0.5	0.7	-1.5	-1.9
Cocaine response before conditioning	0.0	0.1	0.2	0.1	-0.2	-0.4	0.2	-0.2	-0.2
Saline control response	4.6	6.1	8.9	-1.8	2.4	2.1	-2.3	3.0	3.0
Bone: connectivity density	0.9	1.5	3.6	1.9	-1.7	-1.0	0.5	-0.0	1.0
Bone: cortical apparent density	0.4	0.5	0.7	0.6	-0.8	-0.8	0.7	-0.8	-0.7
Bone: cortical area	1.4	2.2	4.5	2.1	-1.8	-1.7	1.4	-0.7	-0.0
Bone: cortical porosity	1.4	1.5	2.8	-1.3	1.0	1.7	-1.5	0.8	0.9
Bone: cortical porosity	1.6	1.8	3.0	-1.4	1.3	1.7	-1.5	1.0	1.0
Bone: cortical thickness	1.0	1.6	3.3	1.8	-1.7	-1.4	1.1	-0.8	-0.1
Bone: cortical thickness	1.6	1.9	2.5	-1.6	1.4	1.6	-1.5	1.2	0.7
Bone: cortical tissue density	0.4	0.5	0.7	0.5	-0.8	-0.7	0.6	-0.8	-0.7
Condit. Reinf. active minus inactive responses	1.4	1.5	2.4	1.5	-1.3	-1.5	1.4	-0.8	-0.3
Condit. Reinf. active-inactive response ratio	2.0	2.2	3.1	1.5	-1.4	-1.8	1.7	-1.4	-1.0
Condit. Reinf. active responses	0.3	0.4	0.6	0.8	-0.7	-0.7	0.7	-0.3	0.0
Condit. Reinf. inactive responses	0.3	0.3	0.7	-0.7	0.5	0.8	-0.6	0.4	0.3
Incentive salience index mean	0.5	0.6	1.0	0.9	-0.7	-1.0	1.0	-0.5	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.5	-0.0	-0.2	-0.1	0.3	-0.5	-0.7
Condit. Reinf. active minus inactive responses	1.5	1.9	2.3	-1.4	1.5	1.2	-1.3	1.5	1.3
Condit. Reinf. active-inactive response ratio	2.1	2.2	2.8	-1.7	1.7	1.2	-1.4	1.6	1.3
Condit. Reinf. active responses	0.8	1.1	1.8	-0.9	1.2	0.7	-0.9	1.4	1.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.5	0.1	-0.3	0.4	0.3	0.1
Condit. Reinf. lever presses	0.2	0.3	0.7	0.4	-0.2	-0.8	0.7	-0.2	-0.4
Condit. Reinf. lever reinforcers received	0.6	0.9	1.7	-0.8	1.1	0.6	-0.7	1.3	1.1
Conditioned reinforcement - actives	0.4	0.4	1.3	0.6	-0.5	-0.0	-0.2	0.6	1.1
Conditioned reinforcement - inactives	0.1	0.1	0.4	0.3	-0.7	-0.2	0.0	-0.3	-0.1
Conditioned locomotion	0.1	0.1	0.3	0.2	0.2	-0.2	0.3	0.4	0.5
Patch foraging indifference point 0 sec	0.8	1.2	1.7	1.2	-1.3	-1.3	1.1	-0.9	-0.6
Patch foraging indifference point AUC	0.0	0.1	0.2	0.3	-0.1	0.0	-0.1	0.2	0.4
Delay disc. indifference point, 0s delay	0.0	0.1	0.1	0.3	-0.2	-0.3	0.2	-0.2	-0.2
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	0.2	-0.2	-0.4	0.8	-0.5	-0.7
Delay disc. indifference point, 2s delay	0.6	0.7	1.7	-1.1	1.3	0.8	-0.4	0.5	-0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.3	0.2	0.2	-0.2	-0.1	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.1	0.2	-0.1	0.5	-0.3	-0.5
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	-0.9	1.0	0.6	-0.4	0.4	-0.0
Indifference point function ln k	0.1	0.1	0.3	0.0	-0.1	-0.1	-0.3	0.4	0.5
Indifference point function log k	0.1	0.1	0.3	0.0	-0.1	-0.1	-0.3	0.4	0.5
Patch foraging total patch changes 0 sec	0.5	0.9	1.3	1.1	-1.0	-1.1	1.0	-0.8	-0.5
Patch foraging total patch changes 12 sec	1.6	2.1	2.7	1.5	-1.6	-1.6	1.5	-1.4	-1.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.7	0.3	-0.7	-0.4	0.2	-0.9	-0.5
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.1	-0.3	-0.4	0.4	-0.5	-0.4
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	0.0	-0.0	-0.4	0.4	-0.1	-0.2
Patch foraging time to switch 0 sec	0.5	0.7	2.2	-0.5	-0.2	-0.3	0.8	-1.1	-1.5
Patch foraging water rate 0 sec	0.3	0.5	1.3	1.1	-0.5	-0.4	-0.1	0.5	1.0
Patch foraging water rate 12 sec	0.4	0.6	1.8	0.5	0.1	0.0	-0.6	1.0	1.3
Patch foraging water rate 18 sec	0.7	1.0	1.5	-0.8	1.2	0.8	-0.9	1.1	1.0
Patch foraging water rate 24 sec	1.7	2.4	5.2	-0.4	1.1	1.0	-1.6	2.0	2.3
Patch foraging water rate 6 sec	0.5	0.7	1.7	1.3	-0.9	-1.1	0.5	-0.3	0.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.7	-0.8	0.8	0.4	-0.1	0.0	-0.8
Distance traveled before self-admin	1.0	1.1	1.5	0.7	-0.9	-0.9	1.1	-1.2	-1.2
Distance traveled after self-admin	0.0	0.0	0.0	-0.0	0.2	0.2	0.1	-0.1	0.1
Extensor digitorum longus weight	0.4	1.7	3.6	1.9	-1.8	-1.5	0.9	-0.5	0.5
Bone: elastic displacement	0.7	0.8	1.3	-0.7	0.8	0.7	-0.9	1.0	1.1
Bone: elastic work	0.4	0.5	1.5	0.4	0.2	-0.1	-0.3	1.0	1.2
Bone: endosteal estimation	0.3	0.7	2.2	-0.0	0.3	0.3	-0.6	1.3	1.5
Bone: endosteal perimeter	0.2	0.5	0.9	1.0	-0.6	-0.8	0.4	0.4	0.8
Epididymis fat weight	4.3	9.9	13.1	3.6	-3.5	-3.3	3.3	-2.8	-2.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	0.7	-0.5	-0.6	0.4	-0.0	0.2
Delta time in open arm before/after self-admin	1.3	1.2	2.7	-1.6	1.2	1.3	-0.6	-0.2	-1.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.6	-0.0	0.2	-0.4	0.8	-0.4	-0.6
Delay discount exponential model param	0.3	0.3	0.9	0.7	-0.9	-0.5	0.0	-0.3	0.2
Extinction: sum of active levers before priming	1.6	1.6	1.9	1.3	-1.4	-1.3	1.0	-1.3	-1.3
Active lever presses in extinction session 6	2.1	2.0	3.0	1.7	-1.7	-1.5	1.4	-1.2	-0.8
Bone: final force	0.1	0.2	0.5	0.3	-0.1	0.0	-0.3	0.5	0.7
Bone: final moment	0.1	0.1	0.5	0.4	-0.2	-0.1	-0.2	0.4	0.7
Food consumed during 24 hour testing period	1.3	1.6	2.5	-1.6	1.5	1.5	-1.1	1.0	0.6
Glucose	0.4	0.5	1.1	0.9	-1.0	-0.5	0.6	-0.7	-0.5
Heart weight	0.6	0.9	2.3	-0.5	0.9	0.3	-0.3	1.5	1.4
Delay discount hyperbolic model param	0.3	0.3	1.0	0.8	-1.0	-0.5	0.1	-0.3	0.1
Intermittent access intake day 1-15 change	1.3	1.2	1.8	-1.0	0.7	1.1	-1.3	1.1	1.4
Intermittent access intake escalation	1.3	1.3	2.2	-0.9	0.7	1.1	-1.3	1.2	1.5
Intermittent access intake escalation 2	1.0	1.0	1.6	-0.9	0.6	1.1	-1.3	0.9	1.2
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.8	0.7	-0.4	-0.8	0.9	-0.3	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.9	0.4	-0.5	-0.6	0.9	-1.0	-1.4
Intermitt. access escalation Index	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.1	-0.0	0.0
Intermittent access day 1 total infusions	1.4	1.6	2.6	-1.5	1.3	1.6	-1.3	1.1	0.6
Intermittent access day 15 total infusions	3.3	3.7	4.7	-1.9	1.7	2.2	-2.1	1.9	1.7
Intermittent access terminal intake (last 3 days)	2.1	2.3	3.5	-1.7	1.3	1.9	-1.7	1.3	1.0
Intermittent access total infusions	2.8	3.1	4.7	-2.0	1.8	2.2	-1.9	1.5	0.9
Intermittent access day 1 locomotion	0.7	0.7	1.4	-1.2	1.0	1.1	-0.7	0.6	0.1
Intermittent access day 15 total locomotion	2.7	2.9	4.2	-1.9	2.0	1.9	-1.6	1.6	0.9
Intermittent access total locomotion	1.9	2.2	3.4	-1.8	1.8	1.8	-1.3	1.2	0.3
Intermittent access standard deviation	0.2	0.2	0.6	-0.2	0.0	0.3	-0.3	0.4	0.7
Left kidney weight	1.7	4.8	12.6	3.5	-2.4	-2.6	1.8	-0.1	0.7
Right kidney weight	2.8	8.0	19.1	4.4	-3.4	-3.3	2.3	-0.8	0.5
Cocaine induced anxiety	0.2	0.3	0.8	0.2	-0.4	-0.2	0.3	-0.7	-0.9
Post-drug Anxiety	0.9	1.0	2.1	-1.5	1.0	1.2	-1.0	0.2	-0.5
Baseline Anxiety	0.1	0.2	0.6	-0.3	0.1	0.0	0.1	-0.5	-0.7
Tail length	2.0	6.0	12.5	-1.2	1.8	1.5	-2.1	3.4	3.5
Length with tail	1.2	4.5	8.8	3.0	-1.4	-2.2	1.0	1.8	2.7
Length without tail	7.2	15.8	31.7	5.6	-4.3	-4.9	4.0	-2.0	-0.7
Times rat made contact with spout	1.3	1.4	2.3	-0.9	1.2	1.0	-1.0	1.5	1.5
Lifetime Intake	1.5	1.7	2.8	-1.5	1.2	1.7	-1.5	1.0	0.5
Liver weight, left	1.3	2.1	5.2	2.3	-1.8	-1.6	1.3	-0.6	0.3
Liver weight, right	0.8	1.4	3.6	1.9	-1.4	-1.1	0.5	0.1	1.1
Locomotor activity	0.2	0.3	1.2	0.5	-0.3	-0.3	0.1	0.6	1.1
Locomotor testing distance	0.1	0.2	0.5	0.7	-0.7	-0.4	0.3	-0.2	0.4
Locomotor testing rearing	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.2	0.0	0.2
Locomotion in novel chamber	4.2	5.2	6.5	-2.2	2.3	2.4	-2.6	2.3	1.8
Locomotion in novel chamber post-restriction	2.2	2.7	5.1	-1.0	1.4	1.1	-1.5	2.2	2.2
Fecal boli incidents, locomotor time 1	0.3	0.4	0.9	0.9	-0.7	-0.7	0.0	0.1	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	-0.3	0.3	-0.0	0.7	-0.4	-1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.7	0.1	-0.2	-0.1	0.2	-0.3	-0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.0	-0.2	-0.3	-0.1	0.0	0.3
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.0	-0.3	-0.3	0.1	-0.3	-0.1
Rest time, locomotor task time 1	0.5	0.5	1.1	-1.1	0.8	0.8	-0.7	0.5	0.3
Distance moved, locomotor task time 1	0.1	0.1	0.5	0.7	-0.5	-0.3	0.3	-0.2	0.1
Vertical activity count, locomotor time 1	0.9	1.0	2.1	1.5	-1.2	-1.1	0.9	-0.6	-0.0
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.5	-0.4	-0.6	0.1	-0.1	-0.1
Bouts of movement, locomotor time 2	0.4	0.5	0.9	0.9	-0.9	-0.7	0.1	0.1	0.8
Total resting periods, locomotor time 2	0.7	0.8	1.7	1.2	-1.3	-1.0	0.6	-0.3	0.3
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.4	0.4	0.1	0.5	-0.0	-0.5
Distance moved, locomotor task time 2	0.2	0.2	0.9	0.4	-0.3	0.1	-0.3	0.3	1.0
Vertical activity count, locomotor time 2	1.1	1.2	2.9	1.7	-1.4	-1.1	0.7	-0.2	0.8
Light reinforcement 1	0.1	0.2	0.5	-0.4	0.2	0.4	0.0	-0.5	-0.7
Light reinforcement 2	0.5	0.7	1.3	0.7	-1.0	-0.4	0.8	-1.2	-0.8
Bone: marrow area	0.4	0.8	2.2	-0.1	0.4	0.4	-0.7	1.3	1.5
Bone: maximum diameter	0.6	1.1	2.6	1.6	-1.3	-1.1	0.8	-0.0	0.7
Bone: maximum force	0.1	0.2	0.6	0.8	-0.4	-0.4	0.1	0.3	0.5
Bone: maximum moment	0.1	0.2	0.7	0.8	-0.5	-0.5	0.1	0.2	0.5
Mean time between licks in bursts	0.3	0.4	0.6	-0.5	0.6	0.7	-0.6	0.7	0.8
Mean num. licks in bursts	0.2	0.2	0.8	-0.4	0.9	0.5	-0.1	0.4	0.1
Cd content in liver	0.1	0.1	0.3	-0.5	0.4	0.1	-0.1	0.2	0.2
Co content in liver	1.7	2.0	2.8	-1.7	1.5	1.7	-1.5	1.1	0.7
Cu content in liver	2.0	2.4	3.7	1.9	-1.9	-1.8	1.6	-1.2	-0.4
Fe content in liver	8.4	10.1	15.0	3.9	-3.9	-3.5	3.1	-2.7	-1.3
K content in liver	0.6	0.6	1.0	-1.0	0.8	1.0	-0.8	0.5	0.2
Mg content in liver	0.9	0.9	1.6	-1.2	1.3	1.0	-0.9	0.8	0.4
Mn content in liver	0.4	0.5	1.0	-0.6	0.5	0.5	-0.8	0.8	1.0
Na content in liver	0.1	0.2	0.3	-0.5	0.5	0.3	-0.4	0.4	-0.1
Rb content in liver	0.9	1.2	2.7	0.3	-0.2	-0.9	1.3	-1.3	-1.6
Se content in liver	3.4	4.2	5.0	1.9	-2.1	-1.9	2.0	-2.2	-2.1
Sr content in liver	0.5	0.5	1.5	-0.1	0.1	0.4	-0.7	0.9	1.2
Zn content in liver	1.0	1.1	2.4	1.6	-1.4	-1.2	0.8	-0.3	0.3
Bone: minimum diameter	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2	0.1	0.2
Time in familiar zone, hab. session 1	0.3	0.3	0.4	0.6	-0.6	-0.5	0.6	-0.5	-0.3
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.0	0.1	0.3
Total zone transitions, hab. session 1	4.5	6.2	8.4	-2.2	2.7	2.3	-2.4	2.9	2.3
Total locomotion distance, hab. session 1	1.4	2.0	2.8	-1.4	1.7	1.5	-1.3	1.5	1.1
Locomotion velocity, hab. session 1	1.8	2.5	3.5	-1.9	1.9	1.9	-1.5	1.3	0.7
Time in familiar zone, hab. session 2	2.3	2.4	3.3	1.7	-1.4	-1.7	1.8	-1.4	-1.1
Time in novel zone, hab. session 2	1.1	1.1	1.5	-1.2	0.9	1.2	-1.2	0.9	0.6
Total zone transitions, hab. session 2	4.2	5.4	7.9	-1.9	1.9	2.6	-2.8	2.4	2.3
Total locomotion distance, hab. session 2	3.2	4.3	6.5	-2.1	1.8	2.6	-2.4	1.8	1.4
Locomotion velocity, hab. session 2	3.4	4.6	7.0	-2.2	1.9	2.6	-2.5	1.8	1.5
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.1	0.2	0.1	-0.2	0.2	0.2
Novelty place preference	0.0	0.0	0.0	0.1	0.0	-0.1	0.0	0.1	0.0
Time in novel zone, NPP test	0.0	0.0	0.1	0.2	-0.1	-0.3	0.1	0.1	0.1
Total zone transitions, NPP test	2.1	3.0	4.5	-1.2	1.3	1.7	-1.9	2.0	2.1
Total locomotion distance, NPP test	1.6	2.2	2.9	-1.7	1.5	1.7	-1.6	1.3	1.0
Locomotion velocity, NPP test	2.7	3.8	4.8	-2.1	1.9	2.2	-2.1	1.8	1.4
Intraocular pressure	0.5	0.7	1.2	1.1	-0.7	-1.1	0.9	-0.5	-0.3
Delta distance traveled before/after self-admin	1.8	1.9	2.6	-1.0	1.5	1.3	-1.3	1.6	1.6
Delta ambulatory time before/after self-admin	0.9	1.0	1.4	-0.7	1.1	1.0	-1.0	1.0	1.2
Parametrial fat weight	0.3	0.5	1.1	0.9	-0.7	-1.0	0.7	0.2	0.3
Pavlov. Cond. lever latency	2.7	3.4	5.9	2.4	-2.2	-2.2	1.7	-1.1	-0.5
Pavlov. Cond. magazine entry latency	3.4	4.4	5.2	-2.2	2.3	2.1	-2.1	2.2	1.6
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	-0.8	0.8	0.4	-0.3	0.3	0.0
Pavlov. Cond. index score	2.2	2.8	4.2	-2.0	2.0	1.8	-1.6	1.4	0.8
Pavlov. Cond. latency score	2.8	3.6	5.4	-2.3	2.2	2.2	-1.9	1.5	0.9
Pavlov. Cond. lever contacts	1.9	2.2	4.7	-2.2	1.9	1.7	-1.2	0.8	0.1
Pavlov. Cond. magazine entry number	2.2	2.8	4.1	1.7	-2.0	-1.6	1.6	-1.8	-1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.6	0.6	-0.6	-0.8	0.8	-0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	3.1	-1.8	1.7	1.6	-1.3	1.1	0.7
Pavlov. Cond. response bias	1.7	2.1	3.2	-1.7	1.8	1.5	-1.3	1.3	0.8
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.3	-0.5	-0.1	0.0	-0.2	0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.3	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.1	0.1	-0.4	0.1	0.4	0.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.3	0.4	0.0	-0.0	0.3	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1	0.3	0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.8	-0.2	0.1	-0.2	0.4	-0.5	-0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.2	0.1	0.5	-0.6	0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.5	-1.0	1.2	1.1	-1.1	1.1	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.3	0.4	0.1	-0.1	0.4	0.2
Pavlov. Cond. response bias	0.2	0.2	0.8	-0.3	0.2	-0.1	0.4	-0.4	-0.9
Time in closed arm before self-admin	0.3	0.3	1.0	0.1	0.0	0.4	-0.6	0.7	1.0
Time in closed arm after self-admin	0.7	0.7	2.7	0.6	-0.1	-0.0	-0.5	1.1	1.6
Time in open arm before self-admin	0.3	0.4	0.7	0.8	-0.5	-0.8	0.5	0.2	0.6
Time in open arm after self-admin	0.2	0.2	0.6	-0.6	0.3	0.2	0.1	-0.4	-0.8
Bone: periosteal estimation	0.3	0.6	1.3	1.1	-0.7	-0.7	0.3	0.5	1.0
Bone: periosteal perimeter	0.9	1.5	3.0	1.7	-1.4	-1.5	1.2	-0.4	0.2
Bone: post-yield work	0.2	0.3	0.4	0.7	-0.6	-0.4	0.4	-0.5	-0.3
Progressive ratio test 1 active lever presses	0.5	0.6	0.8	-0.5	0.5	0.8	-0.8	0.9	0.9
Progressive ratio test 1 breakpoint	1.0	1.1	1.4	-0.8	0.8	1.1	-1.1	1.2	1.1
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.9	-0.1	0.1	0.2	-0.5	0.7	0.9
Progressive ratio test 2 active lever presses	1.8	2.0	3.5	-0.9	1.2	1.2	-1.4	1.9	1.6
Progressive ratio test 2 breakpoint	2.5	2.8	4.5	-1.3	1.5	1.5	-1.8	2.1	1.8
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.4	-0.2	0.5	0.2	-0.5	1.2	1.0
Incentive Sensitization - Responses	1.0	1.0	2.2	-0.8	0.9	0.6	-0.9	1.5	1.1
Incentive Sensitization - Breakpoint	1.1	1.1	2.3	-0.8	1.0	0.7	-1.0	1.5	1.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	-0.2	-0.3	0.1	0.1	0.1
Progressive ratio	0.3	0.4	0.5	-0.7	0.7	0.6	-0.7	0.6	0.1
Food seeking constrained by brief footshock	0.1	0.2	0.5	0.5	-0.7	-0.4	-0.2	-0.2	0.3
Seeking ratio, punishment vs. effort	0.2	0.3	0.6	0.6	-0.8	-0.4	0.1	-0.2	0.5
Retroperitoneal fat weight	4.1	13.4	15.5	3.9	-3.8	-3.9	3.9	-3.4	-3.0
Reaction time number correct	0.2	0.3	0.8	0.9	-0.0	-0.2	0.1	0.7	0.8
Reaction time mean minus median	3.0	3.9	6.8	-2.3	2.6	2.0	-1.7	1.8	1.1
Reaction time mean minus median AUC	2.9	3.7	7.0	-2.3	2.6	2.0	-1.6	1.7	0.7
Reaction time num false alarms	0.2	0.3	0.6	-0.6	0.3	0.8	-0.7	0.3	0.2
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.0	-0.2	-0.2
Reaction time trials correct on left	0.2	0.3	0.8	0.9	-0.0	-0.2	0.1	0.7	0.8
Reaction time trials on left	0.2	0.3	0.7	0.8	0.0	-0.1	0.0	0.7	0.8
Reaction time mean	0.8	1.1	2.6	-1.6	1.3	1.1	-0.5	-0.2	-0.9
Reaction time mean AUC	0.6	0.9	1.9	-1.4	1.2	0.9	-0.3	-0.2	-0.9
Median of all reaction times	0.6	0.9	2.5	-1.1	0.5	0.5	0.1	-1.0	-1.6
Reaction time omissions	0.7	0.9	1.7	-1.1	1.3	1.2	-0.9	0.6	0.1
Reaction time false alarm rate	0.1	0.1	0.3	-0.3	-0.4	0.0	0.1	-0.6	-0.5
Reaction time premature initiation rate	5.9	8.0	12.2	-3.5	3.5	3.1	-2.8	2.3	1.0
Reaction time premature initiations	5.2	7.3	11.0	-2.9	3.3	2.9	-2.7	2.6	1.5
Std. dev. reaction times	1.5	2.1	4.5	-1.8	2.1	1.5	-1.0	1.1	0.2
Reaction time trials completed	0.2	0.3	0.7	0.8	0.0	-0.1	0.0	0.7	0.8
Reaction time trials AUC	0.2	0.3	0.9	1.0	-0.2	-0.3	0.2	0.5	0.6
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.6	0.5	0.5	-0.2	0.3	0.2
Run reversals in cocaine runway, males	0.5	0.5	1.2	1.1	-1.1	-0.5	0.5	-0.4	0.2
Latency to leave start box in cocaine runway	1.3	1.4	2.4	0.6	-1.0	-1.1	1.1	-1.5	-1.6
Latency to leave start box in cocaine runway, F	2.9	3.2	3.7	1.6	-1.8	-1.9	1.8	-1.9	-1.7
Latency to leave start box in cocaine runway, M	1.0	1.0	1.6	-1.3	1.2	1.1	-0.8	0.8	0.4
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.0	0.1	0.0	0.1	0.2	0.1
Total sessions with >9 infusions	0.2	0.2	0.7	-0.1	0.0	0.2	-0.5	0.6	0.8
Short access day 1 total inactive lever presses	0.4	0.4	1.4	0.2	0.0	-0.1	-0.3	0.9	1.2
Short access day 10 total inactive lever presses	0.1	0.1	0.4	-0.5	0.6	-0.1	-0.1	0.4	0.2
Short access day 1 total infusions	0.1	0.1	0.2	0.0	-0.5	0.1	-0.3	-0.2	0.1
Short access day 10 total infusions	1.1	1.2	2.1	-1.1	0.9	1.5	-1.2	1.0	0.8
Short access total infusions	0.3	0.3	0.6	-0.7	0.3	0.8	-0.7	0.3	0.2
Short access day 1 locomotion	0.1	0.1	0.2	-0.3	0.1	0.2	-0.2	0.2	0.4
Short access day 10 total locomotion	0.2	0.2	0.4	0.6	-0.6	-0.2	0.3	-0.3	0.0
Short access total locomotion	0.3	0.3	0.6	-0.8	0.6	0.7	-0.4	0.4	0.4
One hour access (0.3 mA shock)	2.2	2.6	3.4	-1.8	1.6	1.9	-1.7	1.5	1.1
Compulsive drug intake	0.1	0.1	0.4	-0.6	0.4	0.4	-0.2	-0.0	-0.1
One hour access (shock baseline)	0.9	1.0	1.3	-1.0	1.0	1.1	-1.1	1.1	0.8
Social response proportion	1.4	1.5	4.2	-0.1	1.0	0.5	-0.7	1.8	2.1
Social responses	2.2	2.8	4.5	-1.3	2.0	1.2	-1.3	2.1	1.9
Social time	0.1	0.1	0.3	-0.1	-0.0	-0.0	0.3	-0.5	-0.6
Soleus weight	0.3	0.9	1.7	1.3	-1.3	-1.1	0.7	-0.5	0.2
Bone: stiffness	0.0	0.0	0.1	0.1	0.0	0.1	-0.2	0.3	0.1
Tibialis anterior weight	0.3	1.1	2.7	1.3	-1.0	-0.9	-0.0	0.7	1.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.2	0.0	-0.4	0.2	-0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.3	0.0	-0.5	0.5	0.0	-0.2
Time to tail flick, test, before self-admin	0.1	0.1	0.5	0.7	-0.4	-0.1	-0.1	0.2	0.4
Time to tail flick, test, after self-admin	0.4	0.4	0.8	0.6	-0.3	-0.5	0.7	-0.7	-0.9
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.2	0.8	-0.6	-0.8	1.0	-0.8	-1.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.3	0.4	-0.0	0.3	-0.2	-0.5
Tibia length	0.4	1.1	2.5	1.6	-1.0	-1.3	0.7	0.4	0.9
Ambulatory time before self-admin	0.3	0.3	0.6	0.3	-0.5	-0.3	0.6	-0.8	-0.8
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	0.2	0.3	-0.0	-0.0	0.2
Bone: tissue strength	1.0	1.0	2.3	1.5	-1.0	-1.3	0.9	-0.4	0.1
Total heroin consumption	0.2	0.3	0.9	-0.4	0.2	0.3	0.2	-0.6	-0.9
Bone: trabecular number	1.5	2.3	4.9	2.2	-2.1	-1.6	1.2	-0.7	0.2
Bone: trabecular spacing	0.2	0.2	1.0	-0.2	0.2	-0.1	0.2	-0.5	-1.0
Bone: trabecular thickness	2.6	3.1	6.4	2.3	-2.5	-1.7	1.4	-1.4	-0.6
Bone: trabecular tissue density	1.3	1.9	3.1	1.3	-0.9	-1.8	1.6	-1.0	-1.4
Water consumed over 24 hours	0.9	1.1	1.8	-0.6	0.9	1.0	-1.0	1.3	1.3
Number of responses in last shaping day	0.0	0.0	0.1	0.1	-0.1	-0.0	0.2	-0.0	0.4