Hub : Genes

Uspl1

ubiquitin specific peptidase like 1

chr12:10859764–10886761 (-)

Uspl1 RatGTEx page

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Uspl1	0.07	0.04	2.9e-09	0.05	0.06	0.06	0.06	1.4e-06	4.9e-07	2.1e-07	1.3e-07
2	pVTA	isoform ratio	NM_001105906.2	0.03	0.02	3.0e-03	0.01	0.02	0.01	0.02	2.0e-02	5.0e-03	2.6e-02	1.2e-02
3	Liver	isoform ratio	NM_001105906.2	0.03	0.02	3.3e-04	0.02	0.02	0.02	0.02	2.9e-03	1.1e-03	1.2e-03	9.0e-04
4	Brain	mRNA stability	Uspl1	0.06	0.03	1.7e-09	0.07	0.1	0.1	0.09	3.2e-07	1.0e-09	3.4e-09	4.7e-09
5	PL	mRNA stability	Uspl1	0.03	0.02	3.9e-05	0.03	0.04	0.04	0.04	2.6e-04	1.4e-05	6.1e-05	4.4e-05
6	NAcc	mRNA stability	Uspl1	0.04	0.03	2.2e-05	0.03	0.03	0.02	0.03	9.6e-05	5.4e-05	3.6e-04	3.0e-05
7	Adipose	isoform ratio	XM_063271116.1	0.02	0.02	2.6e-03	0.01	0.01	0.01	0.01	2.0e-02	2.8e-02	2.9e-02	5.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	3.1	5.4	9.4	-3.0	-3.0	-3.1	-1.7	-1.7	-1.0	1.9
Area under the delay curve	0.4	0.5	1.0	0.8	0.9	0.5	0.5	0.4	-0.1	-1.0
BMI with tail	2.2	7.7	11.1	-3.1	-3.1	-3.3	-2.5	-2.6	-1.9	2.6
BMI without tail	0.2	0.7	1.8	-0.2	0.4	0.0	1.0	0.9	1.3	-1.1
Body weight	2.4	10.4	41.0	-6.4	-4.6	-2.4	-1.5	-1.0	0.8	0.7
Weight adjusted by age	0.4	0.6	1.5	0.0	0.3	0.7	0.9	0.9	1.2	-0.6
Bone surface	1.7	3.1	6.6	-2.6	-2.4	-2.5	-1.0	-1.0	-0.6	0.7
Bone volume	3.5	6.3	11.0	-3.1	-3.1	-3.3	-2.1	-2.1	-1.7	1.5
Breakpoint value in progressive ratio session	0.3	0.4	0.8	0.1	0.5	0.4	0.8	0.8	0.6	-0.9
Number of licking bursts	0.2	0.3	0.9	0.2	0.0	0.1	0.8	0.8	1.0	0.1
Context. condit. distance diff. score	1.0	1.2	3.6	-1.9	-1.4	-0.3	-1.0	-0.7	-0.4	-1.1
Locomotion velocity, session 1	0.8	0.8	1.2	0.3	0.8	1.1	1.0	1.1	1.0	-0.8
Locomotion distance, session 1	1.0	1.2	2.3	1.3	1.4	0.5	1.5	1.2	1.0	-0.0
Locomotion velocity, session 2	0.8	1.0	2.1	0.8	0.8	0.2	1.5	1.2	1.4	0.2
Locomotion distance, session 2	2.9	4.1	6.8	1.7	2.0	1.4	2.6	2.4	2.5	-0.9
Locomotion velocity, session 3	0.6	0.7	1.0	-0.9	-1.0	-0.7	-0.9	-0.8	-0.9	0.2
Locomotion distance, session 3	0.2	0.3	0.6	0.1	0.5	0.7	0.5	0.6	0.4	-0.5
Stereotopy head waving bouts, day 3	1.1	1.3	3.1	-0.2	0.3	1.0	1.2	1.4	1.8	-1.4
Stereotopy head waving duration, day 3	0.2	0.3	1.2	0.3	0.1	0.4	0.2	0.3	0.4	-1.1
Locomotion velocity, session 7	0.6	0.7	3.8	0.0	0.4	0.8	-0.1	0.0	-0.2	-1.9
Locomotion distance, session 7	0.9	1.1	5.1	0.4	0.8	1.3	0.2	0.4	0.3	-2.3
Stereotopy head waving bouts, day 7	2.9	3.3	4.6	1.6	1.9	2.1	1.9	1.9	1.4	-1.7
Stereotopy head waving duration, day 7	0.9	1.1	1.4	1.2	1.2	1.2	1.2	1.1	0.7	-0.7
Locomotion velocity, session 8	1.2	1.4	2.2	0.7	1.1	1.5	1.3	1.3	1.4	-0.7
Locomotion distance, session 8	0.6	0.9	2.2	-0.5	0.0	0.6	0.9	1.1	1.5	-1.3
Degree of sensitization distance	0.4	0.4	1.7	0.5	0.7	0.6	0.3	0.3	0.4	-1.3
Degree of sensitization stereotypy	0.5	0.6	1.2	1.1	1.0	0.7	0.8	0.7	0.2	-0.3
Conditioned locomotion	0.6	0.7	2.3	1.5	0.6	1.0	0.5	0.6	0.5	-0.4
Cocaine response after cond. corrected	0.9	1.1	2.2	0.1	-0.3	-1.1	-1.0	-1.3	-1.5	1.3
Cocaine response after cond. not corrected	1.2	1.4	2.8	0.0	-0.5	-1.2	-1.1	-1.4	-1.7	1.4
Cocaine response before conditioning	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.3	-0.2	-0.3	-0.3
Saline control response	4.1	5.5	8.2	1.1	1.8	2.5	2.5	2.7	2.9	-2.5
Bone: connectivity density	1.0	1.5	4.6	-2.1	-1.8	-1.4	-0.3	-0.2	0.5	0.1
Bone: cortical apparent density	0.7	0.9	1.8	-0.7	-0.9	-0.7	-1.0	-0.9	-0.9	1.3
Bone: cortical area	0.9	1.3	2.9	-1.7	-1.6	-1.4	-0.8	-0.8	-0.7	-0.0
Bone: cortical porosity	1.1	1.2	2.3	1.5	1.3	0.7	1.3	1.0	0.7	-0.7
Bone: cortical porosity	1.2	1.4	2.2	1.5	1.4	1.0	1.2	1.0	0.7	-1.2
Bone: cortical thickness	0.7	1.1	2.4	-1.4	-1.5	-1.2	-0.9	-0.8	-0.8	0.3
Bone: cortical thickness	1.1	1.4	2.3	1.5	1.1	1.3	0.9	1.0	0.5	-1.5
Bone: cortical tissue density	0.6	0.8	1.9	-0.6	-0.8	-0.7	-0.9	-0.9	-0.8	1.4
Condit. Reinf. active minus inactive responses	1.1	1.2	2.5	-1.6	-1.3	-1.1	-1.1	-0.9	-0.6	0.8
Condit. Reinf. active-inactive response ratio	1.7	1.8	2.7	-1.4	-1.5	-1.2	-1.7	-1.4	-1.1	0.9
Condit. Reinf. active responses	0.3	0.3	0.7	-0.8	-0.6	-0.6	-0.3	-0.3	-0.1	0.7
Condit. Reinf. inactive responses	0.3	0.3	0.7	0.8	0.8	0.3	0.8	0.5	0.4	-0.2
Incentive salience index mean	0.3	0.4	0.7	-0.8	-0.6	-0.7	-0.5	-0.5	-0.5	0.4
Condit. Reinf. lever presses	0.2	0.2	0.5	0.5	0.3	-0.7	-0.1	-0.4	-0.7	0.3
Condit. Reinf. active minus inactive responses	1.5	1.9	3.1	0.9	1.2	1.8	1.3	1.5	1.5	-1.4
Condit. Reinf. active-inactive response ratio	1.8	2.0	2.5	1.1	1.5	1.5	1.5	1.6	1.4	-1.4
Condit. Reinf. active responses	1.1	1.5	2.6	0.5	0.9	1.5	1.2	1.4	1.6	-1.1
Condit. Reinf. inactive responses	0.1	0.2	0.5	-0.5	-0.1	0.5	0.2	0.4	0.7	-0.1
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.5	-0.2	0.1	-0.3	-0.2	-0.2	-0.3
Condit. Reinf. lever reinforcers received	0.9	1.3	2.4	0.2	0.8	1.5	1.1	1.3	1.5	-1.0
Conditioned reinforcement - actives	0.2	0.4	1.0	-0.8	-0.4	-0.2	0.7	0.7	1.0	-0.1
Conditioned reinforcement - inactives	0.2	0.3	0.9	-0.7	-0.6	-1.0	-0.1	-0.2	-0.0	0.6
Conditioned locomotion	0.1	0.1	0.2	-0.4	-0.1	0.1	0.2	0.3	0.5	0.2
Patch foraging indifference point 0 sec	0.7	1.4	2.6	-1.6	-1.6	-1.0	-1.2	-1.0	-0.5	1.0
Patch foraging indifference point AUC	0.0	0.1	0.3	-0.2	-0.1	-0.5	0.1	-0.0	-0.0	-0.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.2	-0.3	-0.1	-0.2	-0.1	-0.2	-0.5
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	-0.2	-0.1	-0.5	-0.4	-0.5	-0.8	-0.2
Delay disc. indifference point, 2s delay	0.8	0.9	1.7	1.2	1.3	0.9	0.7	0.6	-0.0	-1.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	0.6	0.4	-0.0	0.0	-0.1	-0.4	-0.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.6	0.4	-0.4	-0.1	-0.2	-0.6	-0.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	0.8	0.8	0.7	0.4	0.4	0.1	-0.5
Indifference point function ln k	0.1	0.2	0.6	-0.7	-0.3	0.4	0.3	0.5	0.8	0.1
Indifference point function log k	0.1	0.2	0.6	-0.7	-0.3	0.4	0.3	0.5	0.8	0.1
Patch foraging total patch changes 0 sec	0.5	1.0	2.1	-1.4	-1.4	-0.7	-1.1	-0.8	-0.4	0.6
Patch foraging total patch changes 12 sec	1.8	2.4	3.4	-1.8	-1.9	-1.6	-1.6	-1.5	-1.1	1.2
Patch foraging total patch changes 18 sec	0.5	0.7	1.1	-0.4	-0.9	-1.0	-1.0	-1.0	-0.8	0.8
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	-0.4	-0.5	-0.3	-0.5	-0.5	-0.3	0.3
Patch foraging total patch changes 6 sec	0.1	0.1	0.4	-0.6	-0.5	0.2	-0.4	-0.2	-0.3	-0.1
Patch foraging time to switch 0 sec	0.3	0.6	1.9	0.7	0.1	-0.3	-0.8	-1.0	-1.4	0.5
Patch foraging water rate 0 sec	0.3	0.7	2.8	-1.7	-1.0	0.0	0.1	0.4	1.0	-0.3
Patch foraging water rate 12 sec	0.4	0.8	1.6	-1.3	-0.2	0.6	0.6	0.8	1.2	-0.9
Patch foraging water rate 18 sec	1.0	1.5	2.5	0.6	1.3	1.4	1.2	1.3	1.1	-1.6
Patch foraging water rate 24 sec	1.6	2.2	5.3	-0.5	0.7	1.5	1.6	1.8	2.3	-1.0
Patch foraging water rate 6 sec	0.6	0.9	3.7	-1.9	-1.2	-0.1	-0.7	-0.4	0.1	-0.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	1.0	0.9	0.5	1.0	0.0	0.1	-0.1	0.1
Distance traveled before self-admin	1.0	1.3	1.9	-0.2	-0.8	-1.1	-1.3	-1.4	-1.4	1.3
Distance traveled after self-admin	0.2	0.3	1.0	1.0	0.6	0.4	0.2	0.1	-0.1	-0.7
Extensor digitorum longus weight	0.5	2.1	7.2	-2.7	-2.0	-1.4	-1.0	-0.7	0.0	-0.1
Bone: elastic displacement	0.7	0.8	1.4	0.5	1.1	0.6	1.2	1.1	1.2	0.1
Bone: elastic work	0.5	0.7	1.8	-0.7	-0.0	0.8	0.9	1.0	1.3	0.1
Bone: endosteal estimation	0.4	0.9	2.1	-0.4	0.2	0.9	1.1	1.2	1.4	-0.7
Bone: endosteal perimeter	0.2	0.5	2.1	-1.4	-0.8	-0.2	0.1	0.2	0.5	-0.4
Epididymis fat weight	2.1	7.1	10.7	-2.7	-3.3	-3.0	-2.8	-2.7	-2.4	1.3
Delta time in closed arm before/after self-admin	0.2	0.1	0.7	-0.8	-0.3	-0.4	-0.1	-0.0	0.1	0.3
Delta time in open arm before/after self-admin	1.3	1.3	5.6	2.4	1.4	0.7	0.5	0.3	-0.4	-0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.5	-0.2	-0.1	-0.1	-0.5	-0.4	-0.7	-0.0
Delay discount exponential model param	0.5	0.5	1.1	-1.0	-1.0	-0.4	-0.5	-0.4	0.2	1.0
Extinction: sum of active levers before priming	1.2	1.3	1.6	-1.0	-1.1	-1.2	-1.1	-1.2	-1.1	1.2
Active lever presses in extinction session 6	0.8	0.8	1.8	-1.1	-1.3	-0.9	-0.9	-0.8	-0.4	0.3
Bone: final force	0.1	0.2	0.4	-0.1	0.1	0.4	0.6	0.6	0.6	-0.2
Bone: final moment	0.1	0.1	0.3	-0.1	0.1	0.2	0.5	0.5	0.5	0.0
Food consumed during 24 hour testing period	1.1	1.5	4.2	2.1	1.5	0.8	1.2	1.1	0.8	-0.3
Glucose	0.7	1.1	2.5	-0.4	-1.0	-0.9	-1.1	-1.1	-1.1	1.6
Heart weight	0.3	0.5	1.4	-1.2	-0.5	-0.2	0.5	0.5	0.9	0.4
Delay discount hyperbolic model param	0.5	0.5	1.1	-1.0	-1.0	-0.5	-0.5	-0.4	0.2	1.0
Intermittent access intake day 1-15 change	0.1	0.2	0.8	-0.2	-0.1	-0.1	0.5	0.6	0.9	-0.5
Intermittent access intake escalation	0.1	0.1	0.4	-0.3	-0.3	-0.3	0.2	0.3	0.6	0.0
Intermittent access intake escalation 2	0.0	0.1	0.2	0.0	-0.3	-0.4	-0.1	-0.1	0.2	0.2
Intermitt. access day 1 inactive lever presses	0.2	0.6	2.0	-1.4	-0.9	-0.6	-0.3	-0.3	0.1	1.0
Intermitt. access day 15 inactive lever presses	0.4	0.8	2.2	0.4	-0.2	-0.9	-0.9	-1.1	-1.5	0.8
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1	-0.1	-0.2	0.1
Intermittent access day 1 total infusions	1.3	2.1	2.9	1.7	1.6	1.2	1.6	1.5	0.9	-1.3
Intermittent access day 15 total infusions	0.8	1.2	1.9	1.0	0.8	0.7	1.4	1.3	1.2	-1.0
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.3	1.1	0.8	0.2	0.9	0.8	0.6	-0.6
Intermittent access total infusions	0.6	0.7	1.6	1.3	1.0	0.4	1.1	0.9	0.5	-0.5
Intermittent access day 1 locomotion	0.4	0.5	1.4	1.2	0.8	0.6	0.7	0.6	0.4	-0.1
Intermittent access day 15 total locomotion	1.4	2.5	3.6	1.9	1.9	1.6	1.7	1.6	1.0	-1.1
Intermittent access total locomotion	1.0	1.2	2.6	1.6	1.5	0.9	1.2	1.0	0.6	-0.0
Intermittent access standard deviation	0.2	0.4	1.0	-0.5	-0.9	-1.0	-0.5	-0.6	-0.3	0.5
Left kidney weight	1.8	8.1	31.9	-5.7	-4.2	-1.8	-1.5	-1.0	0.7	0.7
Right kidney weight	2.2	9.9	35.3	-5.9	-4.6	-2.5	-1.8	-1.4	0.2	1.3
Cocaine induced anxiety	0.1	0.2	0.5	0.7	0.6	0.5	0.1	0.1	0.0	-0.4
Post-drug Anxiety	0.4	0.4	1.1	1.0	0.5	-0.2	-0.4	-0.6	-0.9	0.1
Baseline Anxiety	0.9	1.1	2.3	-0.4	-0.6	-1.2	-1.0	-1.2	-1.5	1.0
Tail length	2.4	9.3	20.8	-1.3	0.7	2.8	3.1	3.6	4.6	-3.4
Length with tail	1.8	7.7	22.4	-4.7	-2.3	1.1	1.4	2.1	3.7	-2.4
Length without tail	3.2	10.2	37.3	-6.1	-4.7	-2.0	-2.0	-1.4	-0.1	1.3
LgA early post infusion interval	1.8	2.4	4.4	0.1	-0.9	-1.5	-1.8	-1.9	-2.1	1.7
LgA late post infusion interval	2.2	2.6	5.7	0.3	-0.9	-1.3	-1.9	-2.0	-2.4	1.5
LgA early loading	0.3	0.6	1.3	0.8	1.0	0.4	1.1	0.9	0.6	-0.2
LgA late loading	0.6	1.5	2.9	0.4	1.3	0.9	1.6	1.5	1.7	-0.4
LgA early average infusions	0.3	0.3	1.0	-0.4	0.1	-0.0	0.8	0.7	1.0	0.0
LgA late average infusions	1.2	1.8	4.5	-0.4	0.6	1.0	1.5	1.6	2.1	-1.0
LgA early timeout	0.6	0.7	1.9	-1.4	-0.3	0.1	0.7	0.7	1.2	-0.2
LgA late timeout	0.2	0.3	1.3	-1.1	-0.7	-0.2	-0.1	-0.0	0.2	0.4
LgA early titration	1.3	1.8	4.2	-0.6	0.5	0.8	1.8	1.7	2.0	-0.9
LgA late titration	1.0	1.6	5.5	-1.1	-0.0	0.5	1.3	1.5	2.3	-0.4
LgA total infusion	0.7	0.9	2.8	-1.0	-0.1	0.2	1.1	1.1	1.7	-0.5
Times rat made contact with spout	1.1	1.3	2.3	0.5	0.9	1.1	1.3	1.4	1.5	-0.7
Lifetime Intake	0.4	0.5	1.2	1.1	0.8	0.2	0.9	0.7	0.4	-0.2
Liver weight, left	0.6	1.0	3.4	-1.8	-1.6	-0.2	-0.2	0.1	0.4	-0.9
Liver weight, right	0.4	0.6	2.4	-1.5	-1.1	-0.5	0.1	0.1	0.7	0.1
Locomotor activity	0.3	0.4	1.5	-1.2	-0.4	0.0	0.3	0.4	0.7	-0.6
Locomotor testing distance	0.3	0.5	1.2	-1.1	-1.0	-0.8	-0.5	-0.4	-0.1	0.6
Locomotor testing rearing	0.0	0.1	0.3	0.1	-0.1	-0.5	-0.2	-0.1	-0.1	-0.4
Locomotion in novel chamber	6.0	7.7	12.0	2.1	3.0	2.5	3.5	3.3	3.0	-1.8
Locomotion in novel chamber post-restriction	2.0	3.3	6.8	0.6	1.8	1.0	2.6	2.3	2.3	-1.0
Fecal boli incidents, locomotor time 1	0.4	0.5	2.4	-1.6	-1.0	0.1	-0.2	0.0	0.5	-0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.5	0.4	-0.3	-0.1	-0.2	-0.5	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.8	0.2	-0.0	-0.1	-0.0	-0.1	-0.2	0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.2	-0.1	-0.1	0.1	0.1	0.4	-0.5
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	-0.2
Rest time, locomotor task time 1	0.5	0.6	1.1	1.0	0.9	0.7	0.8	0.7	0.7	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.3	-0.3	-0.4	0.1
Vertical activity count, locomotor time 1	0.4	0.9	1.9	-1.4	-1.1	-1.1	-0.7	-0.7	-0.7	0.5
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.4	-0.3	0.2	-0.1	0.0	-0.1	-0.4
Bouts of movement, locomotor time 2	0.4	0.6	2.1	-1.4	-1.1	-0.7	-0.2	-0.1	0.5	-0.3
Total resting periods, locomotor time 2	0.5	1.0	2.7	-1.7	-1.4	-1.2	-0.5	-0.5	0.2	0.3
Rest time, locomotor task time 2	0.1	0.1	0.3	0.5	0.5	0.4	0.1	0.1	0.0	0.4
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.4	0.3	0.3	-0.6
Vertical activity count, locomotor time 2	0.5	0.7	1.9	-1.4	-1.1	-1.2	-0.2	-0.3	0.1	0.3
Light reinforcement 1	0.2	0.4	0.7	0.9	0.5	-0.8	-0.3	-0.5	-0.7	0.8
Light reinforcement 2	0.8	1.3	3.0	-0.5	-0.7	-1.3	-1.0	-1.2	-1.0	1.7
Bone: marrow area	0.4	0.9	2.0	-0.4	0.2	1.0	1.1	1.2	1.4	-0.7
Bone: maximum diameter	0.5	0.9	2.8	-1.7	-1.4	-1.1	-0.3	-0.3	-0.0	-0.2
Bone: maximum force	0.1	0.1	0.2	-0.4	-0.2	0.2	0.3	0.4	0.3	-0.2
Bone: maximum moment	0.0	0.1	0.2	-0.4	-0.2	0.0	0.3	0.3	0.3	-0.0
Mean time between licks in bursts	0.2	0.4	0.7	0.5	0.5	0.9	0.5	0.5	0.6	-0.8
Mean num. licks in bursts	0.2	0.3	0.7	0.4	0.8	0.8	0.3	0.4	0.4	-0.7
Cd content in liver	0.6	0.7	1.3	0.4	0.8	0.5	1.1	1.1	1.1	-0.4
Co content in liver	1.1	1.3	3.4	1.8	1.6	0.6	1.2	1.0	0.6	-0.3
Cu content in liver	1.2	1.4	2.3	-1.1	-1.4	-1.5	-1.2	-1.2	-1.0	0.4
Fe content in liver	5.5	6.7	11.2	-3.0	-3.3	-2.9	-2.7	-2.5	-1.7	1.3
K content in liver	0.1	0.1	0.3	0.4	0.4	-0.6	0.3	0.1	0.1	-0.0
Mg content in liver	0.4	0.4	1.1	0.8	0.8	0.6	0.4	0.4	0.2	-1.1
Mn content in liver	0.4	0.5	1.0	0.2	0.5	0.6	0.8	0.9	1.0	-0.6
Na content in liver	0.1	0.1	0.2	-0.4	-0.1	0.1	0.1	0.0	0.0	0.4
Rb content in liver	0.6	0.7	1.8	0.7	0.3	-0.1	-1.0	-0.9	-1.4	-0.9
Se content in liver	4.7	5.6	9.3	-1.2	-2.1	-3.0	-2.3	-2.6	-2.6	2.3
Sr content in liver	0.3	0.3	0.7	-0.4	0.0	-0.3	0.8	0.7	0.8	-0.2
Zn content in liver	0.8	0.8	2.4	-1.5	-1.3	-1.1	-0.2	-0.2	0.4	0.7
Bone: minimum diameter	0.0	0.1	0.4	0.2	0.1	-0.2	0.2	0.1	-0.2	-0.7
Time in familiar zone, hab. session 1	0.6	0.5	1.3	-0.8	-0.6	-0.9	-0.5	-0.6	-0.3	1.1
Time in novel zone, hab. session 1	0.2	0.2	0.9	-0.4	-0.3	0.5	-0.0	0.1	0.3	-0.9
Total zone transitions, hab. session 1	4.9	6.8	9.1	1.8	2.6	2.8	2.9	3.0	2.5	-2.5
Total locomotion distance, hab. session 1	1.8	2.5	4.6	1.6	1.6	1.7	1.4	1.5	0.9	-2.1
Locomotion velocity, hab. session 1	2.0	2.8	5.1	2.2	1.9	1.7	1.4	1.4	0.6	-2.0
Time in familiar zone, hab. session 2	1.6	1.7	2.6	-1.6	-1.4	-0.8	-1.6	-1.4	-1.3	-0.2
Time in novel zone, hab. session 2	0.7	0.7	1.7	1.3	1.0	0.6	1.0	0.8	0.6	0.3
Total zone transitions, hab. session 2	2.9	3.8	7.0	1.6	2.1	1.4	2.6	2.3	2.2	-0.5
Total locomotion distance, hab. session 2	2.2	2.9	4.9	2.2	2.0	1.2	2.0	1.8	1.4	-0.6
Locomotion velocity, hab. session 2	2.3	3.1	5.3	2.3	2.1	1.2	2.1	1.9	1.5	-0.4
Novel to familiar place preference ratio	0.0	0.1	0.2	-0.0	0.2	-0.1	0.2	0.2	0.1	0.5
Novelty place preference	0.1	0.1	0.3	-0.3	-0.0	-0.1	0.0	0.0	-0.0	0.6
Time in novel zone, NPP test	0.1	0.1	0.4	-0.6	-0.1	-0.1	-0.0	-0.0	0.1	0.6
Total zone transitions, NPP test	1.7	2.4	4.0	0.7	1.3	1.3	2.0	2.0	2.0	-1.1
Total locomotion distance, NPP test	1.4	1.9	2.7	1.6	1.6	1.1	1.6	1.4	1.0	-1.2
Locomotion velocity, NPP test	2.3	3.2	4.2	2.0	2.0	1.4	2.0	1.9	1.3	-1.7
Intraocular pressure	0.4	0.5	1.8	-1.3	-0.9	-0.0	-0.7	-0.5	-0.2	-0.5
Delta distance traveled before/after self-admin	3.1	3.2	4.1	1.6	1.7	1.8	1.9	1.9	1.7	-2.0
Delta ambulatory time before/after self-admin	1.5	1.8	2.6	1.5	1.4	1.1	1.3	1.3	1.0	-1.6
Parametrial fat weight	0.8	2.0	6.6	-2.6	-1.7	-0.9	-1.2	-1.1	-0.5	0.9
Pavlov. Cond. lever latency	2.2	2.8	6.6	-2.6	-2.3	-1.1	-1.4	-1.1	-0.5	1.7
Pavlov. Cond. magazine entry latency	3.2	4.1	4.7	1.6	2.1	2.1	2.1	2.2	1.9	-2.2
Pavlov. Cond. change in total contacts	0.5	0.5	1.6	0.8	0.9	0.5	0.5	0.4	0.1	-1.3
Pavlov. Cond. index score	2.3	3.0	4.2	2.0	2.1	1.5	1.7	1.5	1.0	-2.0
Pavlov. Cond. latency score	2.8	3.6	5.6	2.4	2.3	1.6	1.9	1.7	1.2	-1.9
Pavlov. Cond. lever contacts	2.5	3.0	6.7	2.6	2.4	1.3	1.4	1.1	0.4	-1.9
Pavlov. Cond. magazine entry number	2.9	3.7	6.4	-1.3	-1.9	-2.1	-1.8	-1.9	-1.7	2.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.6	-0.5	-0.5	-0.7	-0.6	-0.6	-0.6	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.4	1.9	1.8	1.2	1.4	1.3	0.8	-1.8
Pavlov. Cond. response bias	2.6	3.3	5.7	1.7	2.0	1.7	1.7	1.7	1.3	-2.4
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.3	-0.5	-0.4	-0.1	-0.1	0.1	0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.1	-0.0	-0.1	-0.4
Pavlov. Cond. change in total contacts	0.2	0.3	1.1	-0.6	0.1	0.6	0.3	0.5	0.5	-1.0
Pavlov. Cond. index score	0.2	0.3	0.6	0.1	0.5	0.7	0.4	0.4	0.3	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.7	0.1	0.4	0.8	0.3	0.4	0.3	-0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	0.4	0.1	-0.2	-0.2	-0.4	-0.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.3	0.1	-0.4	0.1	0.1	0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.8	1.2	0.9	0.9	1.0	0.9	1.0	1.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	0.0	0.4	0.7	0.4	0.5	0.4	-0.8
Pavlov. Cond. response bias	0.1	0.1	0.3	0.4	0.4	0.2	-0.2	-0.1	-0.4	-0.5
LgA PC1 addiction-like behavior	0.5	1.0	2.8	-0.9	0.0	0.1	1.2	1.2	1.7	-0.4
Time in closed arm before self-admin	0.3	0.4	1.2	-0.5	-0.4	0.2	0.7	0.7	1.1	-0.3
Time in closed arm after self-admin	1.0	1.1	2.6	-1.1	-0.3	0.7	1.0	1.2	1.6	-0.7
Time in open arm before self-admin	0.1	0.1	0.4	-0.7	-0.2	0.1	-0.0	0.2	0.2	-0.2
Time in open arm after self-admin	0.6	0.6	2.3	1.5	1.1	0.4	0.1	-0.1	-0.6	-0.5
Bone: periosteal estimation	0.2	0.3	1.1	-1.0	-0.6	-0.1	0.4	0.4	0.6	-0.6
Bone: periosteal perimeter	0.5	0.9	2.9	-1.7	-1.4	-0.8	-0.7	-0.5	-0.4	-0.2
Bone: post-yield work	0.4	0.5	1.3	-0.1	-0.5	-1.1	-0.6	-0.7	-0.9	0.8
Progressive ratio test 1 active lever presses	0.7	0.9	1.4	0.4	0.7	0.5	1.2	1.1	1.2	-1.0
Progressive ratio test 1 breakpoint	0.7	0.8	1.4	0.4	0.7	0.4	1.2	1.1	1.1	-1.0
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	-0.2	0.1	-0.1	0.5	0.5	0.7	-0.0
Progressive ratio test 2 active lever presses	0.9	1.0	2.5	-0.2	0.5	0.6	1.5	1.4	1.6	-0.0
Progressive ratio test 2 breakpoint	0.8	1.0	2.2	-0.2	0.5	0.6	1.4	1.4	1.5	0.0
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.7	-0.8	0.2	0.2	1.1	1.1	1.3	-0.4
ShA PR total presses	1.1	1.3	3.3	0.2	-0.5	-1.7	-0.6	-1.0	-1.1	1.8
Incentive Sensitization - Responses	0.3	0.4	0.9	-0.6	0.1	0.1	0.7	0.7	0.6	0.9
Incentive Sensitization - Breakpoint	0.3	0.4	0.9	-0.5	0.2	0.2	0.8	0.7	0.6	0.9
LgA PR total presses	0.4	0.4	1.5	0.1	-0.2	-1.2	-0.3	-0.6	-0.5	0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	1.2	-1.1	-0.5	-0.2	0.0	0.1	0.3	0.1
Progressive ratio	0.3	0.4	0.7	0.8	0.7	0.6	0.7	0.6	0.6	-0.3
Food seeking constrained by brief footshock	0.5	0.6	1.3	-0.7	-0.9	-0.6	-0.7	-0.6	-0.3	1.2
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	-0.9	-0.7	-0.3	-0.3	-0.1	0.2	0.5
Retroperitoneal fat weight	1.8	7.8	13.8	-3.7	-3.6	-2.4	-2.9	-2.7	-2.2	1.1
Reaction time number correct	0.3	0.5	1.3	-1.1	-0.2	0.1	0.5	0.5	1.1	0.6
Reaction time mean minus median	2.6	6.4	14.4	2.2	2.5	3.0	1.9	2.1	1.3	-3.8
Reaction time mean minus median AUC	2.5	6.4	13.2	2.4	2.5	3.3	1.8	2.0	1.2	-3.6
Reaction time num false alarms	0.1	0.2	0.3	0.5	0.4	0.2	0.5	0.3	0.4	0.5
Reaction time num false alarms AUC	0.0	0.1	0.3	0.1	-0.1	-0.3	-0.1	-0.2	-0.1	0.6
Reaction time trials correct on left	0.3	0.5	1.3	-1.1	-0.2	0.1	0.5	0.5	1.1	0.6
Reaction time trials on left	0.3	0.5	1.2	-1.1	-0.1	0.2	0.6	0.6	1.1	0.5
Reaction time mean	0.9	1.5	4.3	2.1	1.6	1.1	0.2	0.1	-0.8	-1.3
Reaction time mean AUC	0.9	1.4	3.5	1.9	1.5	1.1	0.1	0.1	-0.9	-1.4
Median of all reaction times	0.7	1.0	2.5	1.6	0.9	0.0	-0.6	-0.7	-1.6	-0.1
Reaction time omissions	0.7	1.0	2.2	1.1	1.1	1.5	0.5	0.6	0.3	-1.5
Reaction time false alarm rate	0.1	0.2	0.4	0.4	-0.2	-0.4	-0.4	-0.5	-0.7	0.3
Reaction time premature initiation rate	5.2	7.2	12.1	3.5	3.4	2.9	2.5	2.4	1.6	-1.9
Reaction time premature initiations	3.7	6.6	9.9	2.7	3.1	2.8	2.7	2.6	2.2	-1.7
Std. dev. reaction times	2.2	4.1	9.7	2.2	2.1	2.5	1.3	1.4	0.5	-3.1
Reaction time trials completed	0.3	0.5	1.2	-1.1	-0.1	0.2	0.6	0.6	1.1	0.5
Reaction time trials AUC	0.2	0.4	1.3	-1.2	-0.3	-0.0	0.4	0.4	0.9	0.7
Run reversals in cocaine runway, females	0.3	0.3	1.3	1.1	0.5	-0.1	0.1	-0.0	-0.6	-0.1
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.7	-0.9	-0.6	-0.4	-0.4	-0.1	0.5
Latency to leave start box in cocaine runway	1.7	1.9	4.4	-1.1	-1.7	-0.4	-2.1	-1.7	-1.4	0.1
Latency to leave start box in cocaine runway, F	2.5	2.9	5.2	-1.9	-2.2	-1.0	-2.3	-1.9	-1.3	0.4
Latency to leave start box in cocaine runway, M	0.4	0.4	1.5	0.4	0.4	1.2	0.1	0.3	0.2	-0.7
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.5	0.1	0.4	0.2	0.2	0.1	0.2
Total sessions with >9 infusions	0.2	0.2	0.6	-0.4	-0.5	-0.8	-0.0	-0.1	0.3	0.5
Short access day 1 total inactive lever presses	0.4	0.5	1.7	-1.3	-0.6	0.2	0.3	0.4	0.9	-0.3
Short access day 10 total inactive lever presses	0.2	0.5	1.4	-1.2	-0.7	-0.6	-0.6	-0.6	-0.0	0.7
Short access day 1 total infusions	0.1	0.1	0.6	-0.2	-0.2	-0.8	0.2	-0.0	0.2	0.5
Short access day 10 total infusions	0.3	0.4	0.6	0.8	0.6	-0.1	0.8	0.6	0.6	-0.3
Short access total infusions	0.1	0.2	0.5	0.7	0.4	-0.4	0.4	0.2	0.1	0.3
ShA early post infusion interval	1.1	1.1	2.2	0.6	0.9	1.0	1.1	1.2	1.5	-0.6
ShA late post infusion interval	0.2	0.2	0.3	0.4	0.4	0.4	-0.4	-0.3	-0.5	-0.2
ShA early loading	0.3	0.3	0.8	-0.9	-0.8	-0.4	-0.4	-0.4	-0.5	0.3
ShA late loading	1.1	1.5	3.8	-0.4	-0.4	-1.8	-0.7	-1.1	-1.3	1.9
Short access day 1 locomotion	0.1	0.1	0.3	-0.3	0.0	-0.4	0.4	0.2	0.5	0.5
Short access day 10 total locomotion	0.2	0.4	0.8	-0.9	-0.9	-0.8	-0.3	-0.3	0.1	0.5
Short access total locomotion	0.0	0.1	0.2	0.1	0.1	-0.1	0.2	0.2	0.4	0.2
ShA early average infusions	0.2	0.2	0.5	-0.5	-0.2	0.5	0.5	0.5	0.7	-0.1
ShA late average infusions	0.3	0.3	1.1	-0.2	-0.2	-1.0	0.1	-0.2	-0.0	0.9
ShA early timeout	0.2	0.2	1.0	-1.0	-0.7	0.1	0.1	0.1	0.4	-0.0
ShA late timeout	0.1	0.1	0.3	-0.3	0.1	-0.4	0.5	0.3	0.3	0.3
ShA early titration	0.5	0.5	1.9	-1.4	-1.0	0.0	0.2	0.3	0.8	0.2
ShA late titration	0.2	0.2	0.4	0.6	0.7	-0.4	0.7	0.3	0.1	0.4
ShA total infusions	0.2	0.2	0.6	-0.3	-0.3	-0.8	0.3	0.1	0.3	0.6
One hour access (0.3 mA shock)	2.1	2.5	3.8	1.4	1.6	1.3	1.9	1.8	1.6	-1.2
Shock compulsivity	0.5	1.0	2.6	-1.6	-1.5	-0.8	-0.5	-0.4	0.0	1.1
Compulsive drug intake	0.7	0.8	2.5	1.6	1.2	1.1	0.3	0.3	-0.3	-0.5
One hour access (shock baseline)	0.4	0.6	1.4	0.2	0.6	0.0	1.2	1.0	1.2	-0.5
Social response proportion	2.2	2.5	6.2	-0.3	0.7	1.5	1.5	1.6	1.9	-2.5
Social responses	4.1	5.2	12.2	0.9	1.8	2.7	1.9	2.2	2.2	-3.5
Social time	0.3	0.4	1.4	0.7	0.4	-0.5	-0.2	-0.3	-0.8	-1.2
Soleus weight	0.3	1.0	3.3	-1.8	-1.4	-0.8	-0.7	-0.6	-0.0	-0.6
Bone: stiffness	0.1	0.1	0.5	0.2	0.2	0.7	0.3	0.3	0.2	-0.3
Tibialis anterior weight	0.4	1.4	5.3	-2.3	-1.3	-0.2	0.3	0.5	1.5	-0.6
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.7	-0.4	-0.5	-0.2	-0.8	-0.8	-0.9	0.2
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.4	-1.2	-0.8	0.0	-0.5	-0.4	-0.2	-0.1
Time to tail flick, test, before self-admin	0.3	0.3	1.0	-1.0	-0.7	0.0	0.3	0.3	0.6	-0.1
Time to tail flick, test, after self-admin	0.4	0.5	1.0	-0.1	-0.3	-0.4	-0.8	-0.9	-1.0	0.7
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.1	-1.0	-1.0	-0.9	-1.0	-1.0	-0.8	0.8
Delta time to tail flick, test, before/after SA	0.3	0.3	0.8	0.9	0.7	0.1	-0.3	-0.4	-0.7	0.3
Tibia length	0.5	1.3	5.4	-2.3	-1.5	0.3	-0.0	0.3	1.0	-0.4
Ambulatory time before self-admin	0.4	0.6	1.0	-0.0	-0.5	-0.8	-0.9	-1.0	-0.9	0.9
Ambulatory time after self-admin	0.3	0.3	1.5	1.2	0.5	0.2	0.2	0.1	-0.2	-0.7
Bone: tissue strength	1.0	1.0	2.6	-1.6	-1.1	-0.7	-0.5	-0.5	0.0	1.5
Total heroin consumption	0.3	0.3	1.5	1.2	0.7	-0.0	0.1	-0.1	-0.5	-0.1
Total infusions	0.5	0.7	1.8	-1.2	-0.4	-0.2	0.8	0.7	1.3	-0.0
Bone: trabecular number	1.4	2.4	5.9	-2.4	-2.2	-2.0	-0.9	-0.9	-0.3	0.7
Bone: trabecular spacing	0.2	0.2	0.6	0.2	0.1	0.3	-0.6	-0.6	-0.8	0.4
Bone: trabecular thickness	2.8	3.4	5.8	-2.1	-2.4	-2.4	-1.5	-1.5	-0.9	1.8
Bone: trabecular tissue density	0.6	0.9	1.6	-1.3	-0.9	-0.0	-1.2	-1.0	-1.2	0.6
Water consumed over 24 hours	1.0	1.4	2.8	0.6	1.0	0.9	1.6	1.5	1.7	-0.5
Number of responses in last shaping day	0.3	0.4	0.9	-0.6	-0.6	-0.9	-0.5	-0.6	-0.5	0.5