Hub : Genes

Uspl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Uspl1 0.07 0.04 2.9e-09 0.05 0.06 0.06 0.06 1.4e-06 4.9e-07 2.1e-07 1.4e-07
2 pVTA isoform ratio NM_001105906.2 0.03 0.02 3.0e-03 0.01 0.02 0.01 0.02 2.0e-02 5.0e-03 2.6e-02 1.2e-02
3 Liver isoform ratio NM_001105906.2 0.03 0.02 3.3e-04 0.02 0.02 0.02 0.02 2.9e-03 1.1e-03 1.2e-03 8.6e-04
4 Brain mRNA stability Uspl1 0.06 0.03 1.7e-09 0.07 0.1 0.1 0.09 3.2e-07 1.0e-09 3.6e-09 4.6e-09
5 PL mRNA stability Uspl1 0.03 0.02 3.9e-05 0.03 0.04 0.04 0.04 2.6e-04 1.4e-05 6.1e-05 4.5e-05
6 Adipose isoform ratio XM_063271116.1 0.02 0.02 2.6e-03 0.01 0.01 0.01 0.01 2.0e-02 2.8e-02 2.9e-02 5.7e-02
7 NAcc mRNA stability Uspl1 0.04 0.03 2.2e-05 0.03 0.03 0.02 0.03 9.6e-05 5.4e-05 3.7e-04 3.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density2.95.49.4-3.0-3.0-3.1-1.7-1.7-1.9-1.0
Area under the delay curve0.30.51.00.80.90.50.50.41.0-0.1
BMI with tail2.27.711.1-3.1-3.1-3.3-2.5-2.6-2.6-1.9
BMI without tail0.10.71.8-0.20.40.01.00.91.11.3
Body weight2.410.440.8-6.4-4.6-2.4-1.5-1.0-0.70.8
Weight adjusted by age0.20.61.50.00.30.70.90.90.61.2
Bone surface1.63.16.6-2.6-2.4-2.5-1.0-1.0-0.7-0.6
Bone volume3.16.311.0-3.1-3.1-3.3-2.1-2.1-1.5-1.7
Breakpoint value in progressive ratio session0.20.40.80.10.50.40.80.80.90.6
Number of licking bursts0.10.31.00.20.00.10.80.8-0.11.0
Context. condit. distance diff. score1.01.23.6-1.9-1.4-0.3-1.0-0.71.1-0.4
Locomotion velocity, session 10.70.81.20.30.81.11.01.10.81.0
Locomotion distance, session 11.01.22.31.31.40.51.51.20.01.0
Locomotion velocity, session 20.81.02.10.80.80.21.51.2-0.21.4
Locomotion distance, session 22.94.16.81.72.01.42.62.40.92.5
Locomotion velocity, session 30.60.71.0-0.9-1.0-0.7-0.9-0.8-0.2-0.9
Locomotion distance, session 30.20.30.60.10.50.70.50.60.50.4
Stereotopy head waving bouts, day 31.11.33.1-0.20.31.01.21.41.41.8
Stereotopy head waving duration, day 30.20.31.20.30.10.40.20.31.10.4
Locomotion velocity, session 70.60.73.80.00.40.8-0.10.01.9-0.2
Locomotion distance, session 70.91.15.10.40.81.30.20.42.30.2
Stereotopy head waving bouts, day 72.93.34.61.61.92.11.91.91.71.4
Stereotopy head waving duration, day 70.91.11.41.21.21.21.21.10.70.7
Locomotion velocity, session 81.21.42.20.71.11.51.31.30.71.4
Locomotion distance, session 80.60.92.2-0.50.00.60.91.11.31.5
Degree of sensitization distance0.40.41.70.50.70.60.30.31.30.4
Degree of sensitization stereotypy0.50.61.21.11.00.70.80.70.30.2
Conditioned locomotion0.60.72.31.50.61.00.50.60.40.5
Cocaine response after cond. corrected0.71.12.20.1-0.3-1.1-1.0-1.3-1.3-1.5
Cocaine response after cond. not corrected1.01.42.80.0-0.5-1.2-1.1-1.4-1.4-1.7
Cocaine response before conditioning0.10.10.2-0.4-0.4-0.1-0.3-0.20.3-0.3
Saline control response4.05.58.21.11.82.52.52.72.52.9
Bone: connectivity density0.91.54.6-2.1-1.8-1.4-0.3-0.2-0.10.5
Bone: cortical apparent density0.60.91.8-0.7-0.9-0.7-1.0-0.9-1.3-0.9
Bone: cortical area0.81.32.9-1.7-1.6-1.4-0.8-0.80.0-0.7
Bone: cortical porosity1.11.22.31.51.30.71.31.00.70.7
Bone: cortical porosity1.21.42.21.51.41.01.21.01.20.7
Bone: cortical thickness0.71.12.4-1.4-1.5-1.2-0.9-0.8-0.3-0.7
Bone: cortical thickness1.11.42.31.51.11.30.91.01.50.5
Bone: cortical tissue density0.50.81.9-0.6-0.8-0.7-0.9-0.9-1.4-0.8
Condit. Reinf. active minus inactive responses1.01.22.5-1.6-1.3-1.1-1.1-0.9-0.8-0.6
Condit. Reinf. active-inactive response ratio1.71.82.7-1.4-1.5-1.2-1.7-1.4-0.9-1.1
Condit. Reinf. active responses0.20.30.7-0.8-0.6-0.6-0.3-0.3-0.7-0.1
Condit. Reinf. inactive responses0.30.30.70.80.80.30.80.50.20.4
Incentive salience index mean0.30.40.7-0.8-0.6-0.7-0.5-0.5-0.4-0.5
Condit. Reinf. lever presses0.20.20.50.50.3-0.7-0.1-0.4-0.3-0.7
Condit. Reinf. active minus inactive responses1.31.93.10.91.21.81.31.51.41.5
Condit. Reinf. active-inactive response ratio1.32.02.51.11.51.51.51.61.41.4
Condit. Reinf. active responses1.01.52.60.50.91.51.21.41.11.6
Condit. Reinf. inactive responses0.10.20.4-0.5-0.10.50.20.40.10.7
Condit. Reinf. lever presses0.10.10.3-0.5-0.20.1-0.3-0.20.3-0.3
Condit. Reinf. lever reinforcers received0.91.32.30.20.81.51.11.31.01.5
Conditioned reinforcement - actives0.10.41.0-0.8-0.4-0.20.70.70.11.0
Conditioned reinforcement - inactives0.10.30.9-0.7-0.6-1.0-0.1-0.2-0.6-0.0
Conditioned locomotion0.10.10.2-0.4-0.10.10.20.3-0.20.5
Patch foraging indifference point 0 sec0.51.42.6-1.6-1.6-1.0-1.2-1.0-1.0-0.5
Patch foraging indifference point AUC0.00.10.3-0.2-0.1-0.50.1-0.00.0-0.0
Delay disc. indifference point, 0s delay0.10.10.2-0.2-0.3-0.1-0.2-0.10.5-0.2
Delay disc. indifference point, 16s delay0.10.20.6-0.2-0.1-0.5-0.4-0.50.2-0.8
Delay disc. indifference point, 2s delay0.80.91.71.21.30.90.70.61.1-0.0
Delay disc. indifference point, 24s delay0.10.10.40.60.4-0.00.0-0.10.6-0.4
Delay disc. indifference point, 4s delay0.20.20.40.60.4-0.4-0.1-0.20.2-0.6
Delay disc. indifference point, 8s delay0.20.30.70.80.80.70.40.40.50.1
Indifference point function ln k0.10.20.6-0.7-0.30.40.30.5-0.10.8
Indifference point function log k0.10.20.6-0.7-0.30.40.30.5-0.10.8
Patch foraging total patch changes 0 sec0.31.02.1-1.4-1.4-0.7-1.1-0.8-0.6-0.4
Patch foraging total patch changes 12 sec1.82.43.4-1.8-1.9-1.6-1.6-1.5-1.2-1.1
Patch foraging total patch changes 18 sec0.30.71.1-0.4-0.9-1.0-1.0-1.0-0.8-0.8
Patch foraging total patch changes 24 sec0.00.20.3-0.4-0.5-0.3-0.5-0.5-0.3-0.3
Patch foraging total patch changes 6 sec0.10.10.4-0.6-0.50.2-0.4-0.20.1-0.3
Patch foraging time to switch 0 sec0.20.61.90.70.1-0.3-0.8-1.0-0.5-1.4
Patch foraging water rate 0 sec0.20.72.7-1.7-1.00.00.10.40.31.0
Patch foraging water rate 12 sec0.20.71.6-1.2-0.20.60.60.80.91.2
Patch foraging water rate 18 sec0.71.52.50.61.31.41.21.31.61.1
Patch foraging water rate 24 sec1.52.25.3-0.50.71.51.61.81.02.3
Patch foraging water rate 6 sec0.60.93.6-1.9-1.2-0.1-0.7-0.40.50.1
Seeking ratio, delayed vs. immediate footshock0.20.31.00.90.51.00.00.1-0.1-0.1
Distance traveled before self-admin0.61.31.9-0.2-0.8-1.1-1.3-1.4-1.3-1.4
Distance traveled after self-admin0.20.31.01.00.60.40.20.10.7-0.1
Extensor digitorum longus weight0.52.17.2-2.7-2.0-1.4-1.0-0.70.10.0
Bone: elastic displacement0.60.81.40.51.10.61.21.1-0.11.2
Bone: elastic work0.50.71.8-0.7-0.00.80.91.0-0.11.3
Bone: endosteal estimation0.40.92.1-0.40.20.91.11.20.71.4
Bone: endosteal perimeter0.20.52.1-1.4-0.8-0.20.10.20.40.5
Epididymis fat weight1.47.110.7-2.7-3.3-3.0-2.8-2.7-1.3-2.4
Delta time in closed arm before/after self-admin0.20.10.6-0.8-0.3-0.4-0.1-0.0-0.30.1
Delta time in open arm before/after self-admin1.11.35.52.41.40.70.50.30.5-0.4
Diff in mean of infusions in LGA sessions0.10.10.5-0.2-0.1-0.1-0.5-0.40.0-0.7
Delay discount exponential model param0.40.51.1-1.0-1.0-0.4-0.5-0.4-1.00.2
Extinction: sum of active levers before priming0.91.31.6-1.0-1.1-1.2-1.1-1.2-1.2-1.1
Active lever presses in extinction session 60.80.81.8-1.1-1.3-0.9-0.9-0.8-0.3-0.4
Bone: final force0.10.20.4-0.10.10.40.60.60.20.6
Bone: final moment0.10.10.3-0.10.10.20.50.5-0.00.5
Food consumed during 24 hour testing period0.71.54.22.01.50.81.21.10.30.8
Glucose0.71.12.5-0.4-1.0-0.9-1.1-1.1-1.6-1.1
Heart weight0.30.51.4-1.2-0.5-0.20.50.5-0.40.9
Delay discount hyperbolic model param0.40.51.1-1.0-1.0-0.5-0.5-0.4-1.00.2
Intermittent access intake day 1-15 change0.00.20.8-0.2-0.1-0.10.50.60.50.9
Intermittent access intake escalation0.00.10.4-0.2-0.3-0.30.20.3-0.00.6
Intermittent access intake escalation 20.00.10.20.0-0.3-0.4-0.1-0.1-0.20.2
Intermitt. access day 1 inactive lever presses0.00.62.0-1.4-0.9-0.6-0.3-0.3-1.00.1
Intermitt. access day 15 inactive lever presses0.20.82.30.3-0.2-0.9-0.9-1.1-0.8-1.5
Intermitt. access escalation Index0.00.00.00.10.1-0.0-0.1-0.1-0.1-0.2
Intermittent access day 1 total infusions0.72.12.91.71.61.21.61.51.30.9
Intermittent access day 15 total infusions0.51.21.91.00.80.71.41.31.01.2
Intermittent access terminal intake (last 3 days)0.30.61.31.10.80.20.90.80.60.6
Intermittent access total infusions0.60.71.61.31.00.41.10.90.50.5
Intermittent access day 1 locomotion0.30.51.41.20.80.60.70.60.10.4
Intermittent access day 15 total locomotion0.62.53.61.91.91.61.71.61.11.0
Intermittent access total locomotion1.01.22.61.61.50.91.21.00.00.6
Intermittent access standard deviation0.10.41.0-0.5-0.9-1.0-0.5-0.6-0.5-0.3
Left kidney weight1.08.131.8-5.6-4.2-1.8-1.5-1.0-0.70.7
Right kidney weight1.49.935.2-5.9-4.6-2.5-1.8-1.4-1.30.2
Cocaine induced anxiety0.10.20.50.70.60.50.10.10.40.0
Post-drug Anxiety0.40.41.11.00.5-0.2-0.4-0.6-0.1-1.0
Baseline Anxiety0.61.12.3-0.4-0.6-1.2-1.0-1.2-1.0-1.5
Tail length1.79.320.9-1.30.72.83.13.63.44.6
Length with tail1.77.722.1-4.7-2.31.11.42.12.43.7
Length without tail1.910.137.2-6.1-4.7-2.0-2.0-1.4-1.3-0.1
Times rat made contact with spout1.11.32.30.60.91.11.31.40.71.5
Lifetime Intake0.40.51.21.10.80.20.90.70.20.4
Liver weight, left0.61.03.4-1.8-1.6-0.2-0.20.10.90.5
Liver weight, right0.40.62.4-1.5-1.1-0.50.10.1-0.10.7
Locomotor activity0.30.41.5-1.2-0.40.00.30.40.60.7
Locomotor testing distance0.20.51.2-1.1-1.0-0.8-0.5-0.4-0.6-0.1
Locomotor testing rearing0.00.10.30.1-0.1-0.5-0.2-0.10.4-0.1
Locomotion in novel chamber5.77.712.02.13.02.53.53.31.83.0
Locomotion in novel chamber post-restriction1.13.36.80.61.81.02.62.31.02.3
Fecal boli incidents, locomotor time 10.20.52.4-1.5-1.00.1-0.20.00.40.5
Change in fecal boli incidents, locomotor task0.20.20.50.50.4-0.3-0.1-0.2-0.7-0.6
Time >=10cm from walls, locomotor time 10.10.10.80.2-0.0-0.1-0.0-0.1-0.9-0.2
Bouts of movement, locomotor time 10.10.10.3-0.2-0.1-0.10.10.10.50.4
Total resting periods, locomotor time 10.00.00.0-0.1-0.1-0.1-0.1-0.10.20.1
Rest time, locomotor task time 10.40.61.11.00.90.70.80.70.10.7
Distance moved, locomotor task time 10.00.10.3-0.5-0.3-0.5-0.3-0.3-0.1-0.4
Vertical activity count, locomotor time 10.10.91.9-1.4-1.1-1.1-0.7-0.7-0.5-0.7
Time >=10cm from walls, locomotor time 20.00.10.2-0.4-0.30.2-0.10.00.4-0.1
Bouts of movement, locomotor time 20.20.62.1-1.4-1.1-0.7-0.2-0.10.30.5
Total resting periods, locomotor time 20.21.02.7-1.6-1.4-1.2-0.5-0.5-0.30.2
Rest time, locomotor task time 20.10.10.30.50.50.40.10.1-0.40.0
Distance moved, locomotor task time 20.10.10.3-0.2-0.1-0.20.40.30.60.3
Vertical activity count, locomotor time 20.30.71.9-1.4-1.1-1.2-0.2-0.3-0.30.1
Light reinforcement 10.10.40.70.90.5-0.8-0.3-0.5-0.8-0.7
Light reinforcement 20.61.33.0-0.5-0.7-1.3-1.0-1.2-1.7-1.0
Bone: marrow area0.40.92.0-0.40.21.01.11.20.71.4
Bone: maximum diameter0.40.92.8-1.7-1.4-1.1-0.3-0.30.2-0.0
Bone: maximum force0.00.10.2-0.4-0.20.20.30.40.20.3
Bone: maximum moment0.00.10.2-0.4-0.20.00.30.30.00.3
Mean time between licks in bursts0.10.40.70.50.50.90.50.50.80.6
Mean num. licks in bursts0.10.30.70.40.80.80.30.40.70.4
Cd content in liver0.60.71.30.40.80.51.11.10.41.1
Co content in liver1.11.33.41.81.60.61.21.00.30.6
Cu content in liver1.21.42.3-1.1-1.4-1.5-1.2-1.2-0.4-1.0
Fe content in liver5.46.711.2-3.0-3.3-2.9-2.7-2.5-1.3-1.7
K content in liver0.10.10.30.40.4-0.60.30.10.00.1
Mg content in liver0.40.41.10.80.80.60.40.41.10.2
Mn content in liver0.40.51.00.20.50.60.80.90.61.0
Na content in liver0.00.10.2-0.4-0.10.10.10.0-0.40.0
Rb content in liver0.60.71.90.70.3-0.1-1.0-0.90.9-1.4
Se content in liver4.75.69.3-1.2-2.1-3.0-2.3-2.6-2.3-2.6
Sr content in liver0.30.30.7-0.40.0-0.30.80.70.20.9
Zn content in liver0.70.82.4-1.5-1.3-1.1-0.2-0.2-0.70.4
Bone: minimum diameter0.00.10.40.20.1-0.20.20.10.7-0.2
Time in familiar zone, hab. session 10.50.51.3-0.8-0.6-0.9-0.5-0.6-1.1-0.3
Time in novel zone, hab. session 10.20.20.9-0.4-0.30.5-0.00.10.90.3
Total zone transitions, hab. session 14.86.89.11.82.62.82.93.02.52.5
Total locomotion distance, hab. session 11.82.54.61.61.61.71.41.52.10.9
Locomotion velocity, hab. session 12.02.85.12.21.91.71.41.42.00.6
Time in familiar zone, hab. session 21.51.72.6-1.6-1.4-0.8-1.6-1.40.2-1.3
Time in novel zone, hab. session 20.70.71.81.31.00.61.00.8-0.30.6
Total zone transitions, hab. session 22.93.87.01.62.11.42.62.30.52.2
Total locomotion distance, hab. session 22.22.94.92.22.01.22.01.80.61.4
Locomotion velocity, hab. session 22.33.15.42.32.11.22.11.90.41.5
Novel to familiar place preference ratio0.00.10.2-0.00.2-0.10.20.2-0.50.1
Novelty place preference0.00.10.3-0.3-0.0-0.10.00.0-0.6-0.0
Time in novel zone, NPP test0.10.10.4-0.5-0.1-0.1-0.0-0.0-0.60.1
Total zone transitions, NPP test1.62.44.00.71.31.32.02.01.12.0
Total locomotion distance, NPP test1.31.92.71.61.61.11.61.41.21.0
Locomotion velocity, NPP test2.23.24.22.02.01.42.01.91.71.3
Intraocular pressure0.30.51.8-1.3-0.9-0.0-0.7-0.50.5-0.2
Delta distance traveled before/after self-admin2.93.24.11.61.71.81.91.92.01.7
Delta ambulatory time before/after self-admin1.11.82.61.51.41.11.31.31.61.0
Parametrial fat weight0.82.06.6-2.6-1.7-0.9-1.2-1.1-0.9-0.5
Pavlov. Cond. lever latency2.22.86.6-2.6-2.3-1.1-1.4-1.1-1.7-0.5
Pavlov. Cond. magazine entry latency3.24.14.71.62.12.12.12.22.21.9
Pavlov. Cond. change in total contacts0.50.51.60.80.90.50.50.41.30.1
Pavlov. Cond. index score2.33.04.22.02.11.51.71.52.01.0
Pavlov. Cond. latency score2.83.65.62.42.31.61.91.71.91.1
Pavlov. Cond. lever contacts2.53.06.72.62.41.31.41.11.90.4
Pavlov. Cond. magazine entry number2.93.76.4-1.3-1.9-2.1-1.8-1.9-2.5-1.7
Pavlov. Cond. intertrial magazine entries0.40.51.6-0.5-0.5-0.7-0.6-0.6-1.3-0.6
Pavlov. Cond. lever-magazine prob. diff.1.82.23.41.91.81.21.41.31.80.8
Pavlov. Cond. response bias2.63.35.71.72.01.71.71.72.41.3
Pavlov. Cond. lever latency0.10.10.3-0.3-0.5-0.4-0.1-0.1-0.60.1
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.10.2-0.1-0.00.4-0.1
Pavlov. Cond. change in total contacts0.10.31.1-0.60.10.60.30.51.00.5
Pavlov. Cond. index score0.20.30.60.10.50.70.40.40.80.3
Pavlov. Cond. latency score0.20.20.70.10.40.80.30.40.70.3
Pavlov. Cond. lever contacts0.10.10.20.30.40.1-0.2-0.20.4-0.4
Pavlov. Cond. magazine entry number0.00.00.10.30.1-0.40.10.1-0.20.2
Pavlov. Cond. intertrial magazine entries0.40.81.20.90.91.00.91.00.31.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.00.40.70.40.50.80.4
Pavlov. Cond. response bias0.10.10.30.40.40.2-0.2-0.10.5-0.4
Time in closed arm before self-admin0.20.41.2-0.5-0.40.20.70.70.31.1
Time in closed arm after self-admin0.91.12.6-1.1-0.30.71.01.20.71.6
Time in open arm before self-admin0.10.10.4-0.7-0.20.1-0.00.20.20.2
Time in open arm after self-admin0.60.62.31.51.10.40.1-0.10.5-0.7
Bone: periosteal estimation0.10.31.1-1.0-0.6-0.10.40.40.60.6
Bone: periosteal perimeter0.50.92.8-1.7-1.4-0.8-0.7-0.50.2-0.4
Bone: post-yield work0.30.51.3-0.1-0.5-1.1-0.6-0.7-0.8-0.9
Progressive ratio test 1 active lever presses0.50.91.40.40.70.51.21.11.01.2
Progressive ratio test 1 breakpoint0.50.81.40.40.70.41.21.11.01.1
Progressive ratio test 1 inactive lever presses0.10.10.4-0.20.1-0.10.50.50.00.6
Progressive ratio test 2 active lever presses0.71.02.5-0.20.50.61.51.40.01.6
Progressive ratio test 2 breakpoint0.71.02.2-0.20.50.61.41.4-0.01.5
Progressive ratio test 2 inactive lever presses0.20.71.7-0.70.20.21.11.10.41.3
Incentive Sensitization - Responses0.10.40.9-0.60.10.10.70.7-0.90.6
Incentive Sensitization - Breakpoint0.20.40.9-0.50.20.20.80.7-0.90.6
Sum of active levers in priming session hrs 5-60.20.21.2-1.1-0.5-0.20.00.1-0.10.3
Progressive ratio0.10.40.70.80.70.60.70.60.30.6
Food seeking constrained by brief footshock0.40.61.3-0.7-0.9-0.6-0.7-0.6-1.2-0.3
Seeking ratio, punishment vs. effort0.10.20.7-0.9-0.7-0.3-0.3-0.1-0.50.2
Retroperitoneal fat weight1.77.813.8-3.7-3.6-2.4-2.9-2.7-1.1-2.2
Reaction time number correct0.10.51.2-1.1-0.20.10.50.5-0.61.1
Reaction time mean minus median1.06.414.42.22.53.01.92.13.81.3
Reaction time mean minus median AUC1.06.413.22.42.53.31.82.03.61.2
Reaction time num false alarms0.10.20.30.50.40.20.50.3-0.50.4
Reaction time num false alarms AUC0.00.10.30.1-0.1-0.3-0.1-0.2-0.6-0.1
Reaction time trials correct on left0.10.51.2-1.1-0.20.10.50.5-0.61.1
Reaction time trials on left0.10.51.2-1.1-0.10.20.60.6-0.51.1
Reaction time mean0.71.54.32.11.61.10.20.11.3-0.9
Reaction time mean AUC0.61.43.51.91.51.10.10.11.4-0.9
Median of all reaction times0.60.92.51.60.90.0-0.6-0.70.1-1.6
Reaction time omissions0.61.02.21.11.11.50.50.61.50.3
Reaction time false alarm rate0.10.20.40.4-0.2-0.4-0.4-0.5-0.3-0.7
Reaction time premature initiation rate4.67.212.13.53.42.92.52.41.91.6
Reaction time premature initiations2.26.69.92.73.12.82.72.61.72.1
Std. dev. reaction times1.24.19.72.22.12.51.31.43.10.5
Reaction time trials completed0.10.51.2-1.1-0.10.20.60.6-0.51.1
Reaction time trials AUC0.10.41.3-1.2-0.3-0.00.40.4-0.70.9
Run reversals in cocaine runway, females0.20.31.21.10.5-0.10.1-0.00.1-0.6
Run reversals in cocaine runway, males0.30.30.7-0.7-0.9-0.6-0.4-0.4-0.5-0.1
Latency to leave start box in cocaine runway1.41.94.4-1.1-1.7-0.4-2.1-1.7-0.1-1.4
Latency to leave start box in cocaine runway, F2.32.95.2-1.9-2.2-1.0-2.3-1.9-0.4-1.3
Latency to leave start box in cocaine runway, M0.40.41.50.40.41.20.10.30.70.2
Std. dev. time between licks in bursts0.00.10.20.40.10.40.20.2-0.20.1
Total sessions with >9 infusions0.20.20.6-0.4-0.5-0.8-0.0-0.1-0.50.3
Short access day 1 total inactive lever presses0.20.51.7-1.3-0.60.20.30.40.30.9
Short access day 10 total inactive lever presses0.10.51.4-1.2-0.7-0.6-0.6-0.6-0.7-0.0
Short access day 1 total infusions0.10.10.6-0.2-0.2-0.80.2-0.0-0.50.2
Short access day 10 total infusions0.20.40.60.80.6-0.10.80.60.30.6
Short access total infusions0.10.20.50.70.4-0.40.40.2-0.30.1
Short access day 1 locomotion0.10.10.3-0.30.0-0.40.40.2-0.50.5
Short access day 10 total locomotion0.10.40.8-0.9-0.9-0.8-0.3-0.3-0.50.1
Short access total locomotion0.00.10.20.10.1-0.10.20.2-0.20.4
One hour access (0.3 mA shock)2.12.53.81.41.61.31.91.81.21.6
Compulsive drug intake0.50.82.51.61.21.10.30.30.5-0.3
One hour access (shock baseline)0.20.61.40.30.60.01.21.00.51.2
Social response proportion2.02.56.2-0.30.71.51.51.62.51.9
Social responses4.05.212.20.91.82.71.92.23.52.1
Social time0.30.41.40.70.4-0.5-0.2-0.31.2-0.8
Soleus weight0.31.03.3-1.8-1.4-0.8-0.7-0.60.6-0.0
Bone: stiffness0.10.10.50.20.20.70.30.30.30.2
Tibialis anterior weight0.41.45.2-2.3-1.3-0.20.30.50.61.5
Time to tail flick, vehicle, before self-admin0.30.40.7-0.4-0.5-0.2-0.8-0.8-0.2-0.9
Time to tail flick, vehicle, after self-admin0.20.41.4-1.2-0.80.0-0.5-0.40.1-0.2
Time to tail flick, test, before self-admin0.30.31.0-1.0-0.70.00.30.30.10.7
Time to tail flick, test, after self-admin0.40.51.0-0.1-0.3-0.4-0.8-0.9-0.7-1.0
Delta time to tail flick, vehicle, before/after SA0.80.91.1-1.0-1.0-0.9-1.0-1.0-0.8-0.8
Delta time to tail flick, test, before/after SA0.20.30.80.90.70.1-0.3-0.4-0.3-0.7
Tibia length0.51.35.3-2.3-1.50.3-0.00.30.41.0
Ambulatory time before self-admin0.20.61.0-0.0-0.5-0.8-0.9-1.0-0.9-0.9
Ambulatory time after self-admin0.20.31.51.20.50.20.20.10.7-0.2
Bone: tissue strength1.01.02.6-1.6-1.1-0.7-0.5-0.5-1.50.0
Total heroin consumption0.30.31.51.20.7-0.00.1-0.10.1-0.5
Bone: trabecular number1.32.45.9-2.4-2.2-2.0-0.9-0.9-0.7-0.2
Bone: trabecular spacing0.20.20.70.20.10.3-0.6-0.6-0.4-0.8
Bone: trabecular thickness2.53.45.8-2.1-2.4-2.4-1.5-1.5-1.8-0.9
Bone: trabecular tissue density0.50.91.6-1.3-0.9-0.0-1.2-1.0-0.6-1.2
Water consumed over 24 hours0.71.42.80.61.00.91.61.50.51.7
Number of responses in last shaping day0.30.40.9-0.6-0.6-0.9-0.5-0.6-0.5-0.5